Kendriya Vidyalaya No.

1 Indore

Chemistry Investigatory Project

The Neutralizing Ability of Antacid Tablets

Submitted by: Vishlesh Parmar 12thB

Submitted to: Mrs Anita Mitra mam

 CERTIFICATE

This is to certify that Vishlesh Parmar of class

12th B has successfully completed this project
on the topic:- “ The Neutralizing Ability of
Antacid Tablets“, prescribed by Mrs Anita
Mitra during the Academic session 2021-22 as
per the guidelines issued by the Central Board
of Secondary Education .
It is further certified that this project is the
individual work of candidate.
 ACKNOWLEDGEMENT

I would like to express my special thanks and

my gratitude to my teacher Mrs Anita Mitra
who gave me this wonderful opportunity to
perform such a great , informative experiment
and helped me when needed. I came to know
about so many new things and I am really
thankful to her. I would also give a vote of
thanks to the principal Dr P.K Beduye for
providing me with all the facility that was
required.

Vishlesh Parmar
12th B

Mrs Anita Mitra

Chemistry

Dr. P.K Beduye

Principal
Content
CONTENT

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Aim:-
The purpose of this experiment was to determine which antacid could neutralize the
most stomach acid. I became interested in this idea when I saw some experiments
on medicines and wanted to find out some scientific facts about medicines.

The information gained from this experiment will help people know which antacid
they should look for in the stores. It will also let them know which antacid will give
them the most comfort. This could also save consumers money and provide better
health.

Introduction:-

ACIDS-

Acids are a group of chemicals, usually in liquid form. They can be recognized by
their sour taste and their ability to react with other substances. Acids are confirmed
as an acid by their pH. The pH of acids ranges from 0-6.9 (below 7). The two main
acids are: mineral acid and organic acid. The three well known acids that are
sulphuric acid (H2S04), nitric acid (HN03), and hydrochloric acid (HCl).

STOMACH ACID-

Stomach acid is very dangerous. If a person was to have an ulcer and the stomach
acid was to escape it would irritate their other organs. Stomach acid is highly acidic
and has a pH of 1.6. Stomach acid is hydrochloric acid produced by the stomach. If
there is too much stomach acid it can cause heartburn. Heartburn is when stomach
acid is produced in abnormal amounts or location. One of the symptoms of
heartburn is a burning feeling in the chest or abdomen.

SOME FOODS CONTAINING ACIDS-

Almost all foods and drinks and even medicines have ingredients that are different
acids. Here are some examples: Aspirin (acetylsalicylic acid), Orangejuice (ascorbic
acid/Vitamin C), Sour Milk (lactic acid), Soda Water (carbonic acid), Vinegar (acetic
acid), Apples (malic acid), and Spinach (oxalic acid).
ANTACID-

An antacid is any substance that can neutralize an acid. All antacids are bases. A
base is any substance that can neutralize an acid. The pH of a base is 7.1-14(above
7). All antacids have chemical in them called a buffer. When an antacid is mixed with
an acid the buffer tries to even out the acidity and that is how stomach acid gets
neutralized. In an antacid it is not the name brand that tells how well it works it is
something called an active ingredient. Not all antacids have a different active
ingredient. Some have one of the same active ingredients and some have all of the
same active ingredients. Almost all the antacids that have the same active
ingredient work the same amount as the other. The active ingredient of most of the
antacids is bases of calcium, magnesium, aluminium.

ACTION MECHANISM-

Antacids perform neutralization reaction, i.e. they buffer gastric acid, raising the pH
to reduce acidity in the stomach. When gastric hydrochloric acid reaches the nerves
in the gastrointestinal mucosa, they signal pain to the central nervous system. This
happens when these nerves are exposed, as in peptic ulcers. The gastric acid may
also reach ulcers in the esophagus or the duodenum. Other mechanisms may
contribute, such as the effect of aluminium ions inhibiting smooth muscle cell
contraction and delaying gastric emptying.
Antacids are commonly used to help neutralize stomach acid. Antacids are bases
with a pH above 7.0 that chemically react with acids to neutralize them. The action
of antacids is based on the fact that a base reacts with acid to form salt and water.

INDICATIONS-

Antacids are taken by mouth to relieve heartburn, the major symptom of gastro
esophageal reflux disease, or acid indigestion. Treatment with antacids alone is
symptotic and only justified for minor symptoms. Peptic ulcers may require H2-
receptor antagonists or proton pump inhibitors. The usefulness of many
combinations of antacids is not clear, although the combination of magnesium and
aluminium salts may prevent alteration of bowel habits.
SIDE EFFECTS-

Aluminium hydroxide: may lead

to the formation of insoluble
aluminium phosphate complexes,
with a risk for hypophosphate and
osteomalacia. Although
aluminium has a low
gastrointestinal absorption,
accumulation may occur in the
presence of renal insufficiency.
Aluminium containing drugs may
cause constipation. Magnesium
hydroxide: has a laxative property.
Magnesium may accumulate in
patients with renal failure leading
to hypo magnesia, with
cardiovascular and neurological
complications. Calcium:
compounds containing calcium
may increase calcium output in
the urine, which might be
associated to renal stones.
Calcium salts may cause
constipation. Carbonate: regular high doses may cause alkalosis, which in turn may
result in altered excretion of other drugs, and kidney stones.
Theory:-
Theory :
L Antacids react with excess stomach acid by neutralization.
HCl + NaOH → H2O + NaCl

L During the process, hydrogen ions H+ from the acid (proton donor) or a
hydronium ion H3O+ and hydroxide ions OH- from the base (proton acceptor)
react together to form a water molecule H2O.
L In the process, a salt is also formed when the anion from acid and the cation
from base react together. Neutralization reactions are generally classified as
exothermic since heat is released into the surroundings.
L Acids are proton donors which convert into conjugated bases. They are
generally pure substances which contain hydrogen ions (H+) or cause them
to be produced in solutions.
L Hydrochloric acid (HCl) and sulfuric acid (H2SO4) are common examples. In
water, these break apart into ions:

HCl → H+(aq) + Cl- (aq)

(OR)
H2SO4 → H+(aq) + HSO4-(aq)

L Bases are proton acceptors which convert into conjugated acids. They are
generally substances which contain hydroxide ion (OH-) or produce it in
solution.
L Alkalis are the soluble bases, i.e. a base which contains a metal from group 1
or 2 of the periodic table. To produce hydroxide ions in water, the alkali
breaks apart into ions as below:

NaOH→Na+(aq)
NaOH→ -
(aq)+OH (aq)

L Examples of bases include sodium hydroxide (NaOH), potassium hydroxide

(KOH), magnesium hydroxide (Mg(OH)2), and calcium hydroxide (Ca(OH)2).
Antacids are generally bases.
REQUIREMENTS:-
Requirements :
a.Apparatus:

L Burette(50ml)

L Pipette(20ml)

L Conical Flasks(250ml)

L Measuring Cylinder(10ml)

L Beakers(100ml)

L Standard Flasks(100ml)

L Filter Paper

L Funnel

L Bunsen Burner

L Weighing machine

L Clean & glazedwhite tile

L Glass Rod

L Water

L Crusher
b. Chemicals:

L NaOH powder

L Na2CO3 powder

L 10M conc. HCl acid

L Four different brands of antacids

L Phenolphthalein

L Methyl Orange
Procedure :
PROCEDURE:-
L First prepare 1 litre of approximately N/10 solution of HCl by diluting 10ml of
the given 10M HCl acid to 1litre.

L Next prepare1litre of approx.N/10NaOH solution by dissolving 4.0g of NaOH

to make1litre of solution.

L Similarly prepare N/10 Na2CO3 solution by weighing exactly 1.325g of

anhydrous Na2CO3 and then dissolving it in water to prepare exactly 0.25L or

250 ml of Na2CO3 solution.

L Now, standardize the HCl solution by titrating it against the standard

Na2CO3 solution using methyl orange as indicator.

L Similarly standardize the NaOH solution by titrating it against standardized

HCl solution using phenolophtahlein as indicator. Stop the titration when the

pink colour of the solution disappears.

L Now, powder the four antacid samples and weigh 0.5 g of each.
L Add 25 ml of the standardised HCl to each of the weighed samples taken in
conical flasks. Make sure that the acid is in slight excess so that it neutralize

all the basic character of the tablet powder.

L Add a few drops of phenolphthalein indicator and warm the flask over a
bunsen burner till most of the powder dissolves.

L Filter the insoluble material.

L Titrate this solution against the standardized NaOH solution till a permanent
pinkish tinge is obtained.

L Repeat the same experiment for all other samples too.

OBSERVATIONS:-
Observations :
L Standardisation of HCl solution:

Volume of 0.1N Na2CO3 taken is 20 ml

Indicator used is Methyl Orange

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1. 0 17 17
2. 18 35 17

Applying normality equation,

N 1 V1 = N 2 V2
(acid) (base)

N1 x 17 = 0.1 x 20
Normality of HCl, N1= 2/17 = 0.11 ≈ 0.1

Standardization of NaOH Solution:

L Volume of the given NaOH solution taken is 20.0 ml

Indicator used is Phenolphthalein
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Cvsfuuf!sfbejoht! Wpmvnf!pg!!
Op/!
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1. 0 16 16
2. 17 33 16

Volume of acid used = 16 ml

Applying normality equation,
N1 V’1 = N’2 V’2
(acid) (base)
0.11 x 16 = N’2 x 20
Normality of HCl, N’2 = (0.11*16) / 20 = 0.09 ≈ 0.1
L Analysis of antacid tablets:
• Weight of the antacid tablet powder = 0.5 g

• Volume of HCl solution added = 30 ml

• Volume of sample solution taken for titration = 20 ml

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1. Eno pineapple 29
2. Eno Lemon 24
3. Digene Lime 9
4. Omez 24
5. Pephyrous 40
6. Gelusil 22

RESULT:-
Result :
L 1g of Eno Pineapple required 29 ml of Sodium Hydroxide (NaOH) to titrate it
completely.
L 1 g of Eno Lemon required 24 ml of Sodium Hydroxide (NaOH) solution to
titrate it completely.
L 1 g of Digene lime required 9 ml of Sodium Hydroxide (NaOH) to titrate it.
L 1 g of Omez required 24 ml of Sodium Hydroxide (NaOH) to titrate it
completely.
L 1 g of Pephyrous required 40 ml of Sodium Hydroxide (NaOH) to titrate it
completely.
L 1 g of Gelusil required 22 ml of Sodium Hydroxide (NaOH) to titrate it
completely.
L Based on the hypothesis of the experiment, the antacid which requires the
least amount of Sodium Hydroxide (NaOH) is the best antacid. From the
recorded observation, Digene© requires the least (5 ml), and is therefore the
best Antacid.
 BIBLIOGRAPHY
bibliography
L http://www.reachoutmichigan.org/funexperiments/quick/csustan/ antacid

L http://ien2.uneche.maine.edu/genchemlabs/Antacid /antacid2.htm

L http://www.chem.latech.edu/~deddy/chem104/104 Antacid.htm

L http://www.images.google.com

L http://www.wikipedia.com