ANP1105E

Fall 2020

ANP1105E
ANATOMY & PHYSIOLOGY I: Basic Cellular Physiology & the Anatomy and Physiology of
the Cardiovascular, Lymphatic & Respiratory Systems
September - December, 2020

Course Description
This is the first of three ANP courses offered within the Faculty of Health Sciences. This course provides an
introduction to tissue and cell morphology, biochemistry of the cell and physiological concepts including diffusion,
osmosis, membrane transport and homeostasis. The physiology of nerve and muscle cells will be examined followed by
in-depth study of the anatomy and physiology of blood and the cardiovascular, lymphatic and respiratory systems. This is
a 3-credit course, with 3 hours of on-line lectures per week during the fall term.

Course Schedule: TUESDAYS 2:30 PM - 4:00 PM

FRIDAYS 4:00 PM - 5:30 PM
Lecture recordings will be available online. While the university has assigned specific times for lecture for
administrative purposes, you may view the lectures any time after they have been released.

Professors: Dr. Joanne Savory, RGN 3105K Dr. R. Russell, RGN 3159A
Course Coordinator [email protected]
[email protected] 613-562-5800, ext. 7265

Office hours: Office hours will be virtual

Textbook: Marieb, E. N. & Hoehn, K. (2019) Human Anatomy & Physiology 11th Edition. Pearson
Education Inc.
The textbook package is available at the main bookstore ( https://www.bkstr.com/ottawastore/home)

You will need the book AND the online access code for Mastering A&P that is packaged with the book in
order to be able to do the Mastering A&P assignments. The purchasing options are as follows:
 Hardcover textbook packaged with the Mastering A& P Access Code (most expensive option)
 Loose-leaf version (unbound) of the textbook packaged with the Mastering A&P Access Code
 E-book packaged with the Mastering A &P Access Code
 Stand Alone Mastering A & P Access Code (should you choose to buy a used version of the text)

The Mastering Course ID for ANP1105E is savory00607

The login URL: https://www.pearsonmylabandmastering.com/northamerica/

Website: Go to university’s home page; Click on the ‘Students’ link in the top banner menu
Click on ‘Log into Brightspace’.
Enter your username and password.
Click “Login” and this will bring you to a list of courses for which you have online access.
Select ANP1105E to access the course website.

Power-point lecture slides and/or PDF documents of the lecture material will be made available in Brightspace prior to the
lecture. Lecture videos will be available in Echo360.
You should always try to review the lecture slides and/or the relevant pages in the text before viewing the lecture
videos.

EVALUATION
There will be three exams as well as online assignments throughout the duration of the course, as indicated below.
Exams will be mixed format i.e. a combination of multiple choice, true/ false, matching, fill-in-the-blanks and short
answer questions and diagrams to be labelled. The exam questions will ONLY include the material covered in the
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lectures, thus the lectures are the best indicator of the depth and breadth of topics for which exam questions will be
developed. The syllabus details which topics will be tested on each exam. We do not deviate from the syllabus so please
consult the course syllabus if you are unsure of the topics that will be tested on a given exam.
Your grade will be based entirely on the exams (3), the Mastering A&P (9) and Brightspace/D2L (3) assignments. It is
not possible to obtain extra credit from additional assignments and/or exams. However, supplemental exams are offered
for students who obtain an overall grade of E (see details below). The distribution of marks is final and it is not
possible to change the weight of the exams or assignments.

EXAM DATE % of Final Mark

Midterm 1 (Topics 1 & 2) Tuesday, October 6th 25
Midterm 2 (Topic 3 and Topics 4.1 & 4.2) Tuesday, November 17th 25
Brightspace Assignments (see schedule below) Throughout the semester 3
Mastering A&P (see schedule below) Throughout the semester 7
Final Exam (Dec 10 – Dec 22) 40
Total 100%

EXAMS
Exam 1 will deal with all material from the Structural Organization of the Human Body up to and including
Introduction to Nerve & Muscle and is worth 25% of the final grade.
Exam 2 will deal with Homeostasis, Blood and the Heart and is worth 25% of the final grade.
Exam 3 (the final exam) will concentrate on Blood Vessels & Hemodynamics as well as the Lymphatic and
Respiratory systems. However 10-15 % of the final exam will be composed of questions dealing with material
covered in the two midterms. The final exam is worth 40% of the final grade.

All exams will be online in Brightspace. We will not be using the Respondus browser for exams. While the
lecture videos can be viewed at any time (although it is strongly recommended that you keep up with the
lecture schedule) exams must be written on the date and at the times specified below. Exams
times are based on Ottawa time so if you are living in a different time zone please take note.
A summary of the number of questions will be posted in Brightspace a day or two before the exa m

What to do if you miss an exam

If you have to miss an exam due to illness, you must notify the course coordinator (Dr. Savory) before the exam
takes place. You have 5 school days from the day of the exam to provide appropriate medical documentation
indicating that you were seen by your family physician or by University Health Services on or before exam day
and found by that health care provider to be too ill on exam day to write your exam. Only then will you be eligible
to write a deferred exam. Medical notes dated after the exam date are not considered to be valid. If you do not
write the regular exam or deferred exam, you will obtain a zero for that section of the course. You should
familiarize yourself with the University’s academic regulations and the policy on Medical Certificates
(https://www.uottawa.ca/health/).

For those with valid medical documentation,

 The deferred midterm 1 exam will only be held on Thursday, October 29th beginning at 1 PM
o If you miss the deferred exam and have a valid medical certificate the doubly deferred midterm 1 exam will
take place in February 2021 during Reading Week.
 The deferred midterm 2 exam will only be held on Friday, November 27th beginning at 9 AM.
o If you miss the deferred exam the doubly deferred midterm 2 exam will take place in February 2021 during
Reading Week
 The deferred final exam will take place in February 2021 during Reading week.

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Supplemental exams: Supplemental Exams are now available for those students who fail an ANP course but do well
enough to obtain an E. Students who fail with an F are not eligible for a supplemental exam and must repeat
the course. The supplemental exam score will replace the original final exam score in the new calculation of the
student’s final grade. While both final grades will appear on the student’s transcript, only the supplemental mark will
be used for grade point calculations. The supplemental exam for ANP1105E will take place during the winter term
Reading Week (February 2021) and the regulations regarding illness on exam day indicated in the preceding section
also apply to this exam.

If you are eligible to write the supplemental exam you will receive an email informing you of your eligibility. If you’d like
to write the exam, there is no registration, simply confirm you intent to write the exam and show up at the time and
place detailed in the email. You will eventually have to pay supplemental examination fees.

ASSIGNMENTS
The three exams (2 midterms and 1 final) count for 90% of the final grade. The remaining 10% of the grade will be
from online assignments on the Mastering A&P website throughout the term (see below for Mastering A&P schedule) and
from assignments (3) on Brightspace (see schedule below). You do not need an access code to complete the
assignments in Brightspace but you must have an access code to be able to do the assignments on the Mastering A&P
website.
The due date for assignments are final and no extensions will be granted so please pay careful attention to the
deadline. The excuse of having forgotten the due date or that you were ill will not be accepted as you have an entire
week in which to complete assignments that require less than an hour.
Learning is not the product of teaching. Learning is the product of the activity of learners. - John Holt

Brightspace Assignments Available (always 6 PM) Due Date (always 10 PM )

[1] Pre course Self-Assessment Friday, September 11th Thursday, September 17th
[2] Post Midterm 1 Self-Assessment Wednesday, October 14th Tuesday, October 20th
[3] Post Midterm 2 Self-Assessment Tuesday, November 24th Monday, November 30th

Mastering A&P Assignments Available (always 6 PM) Due Date (always 10 PM )

[1] Cells and Tissues Friday, September 18th Thursday, September 24th
[2] Membrane Transport and the Neuron Friday, September 25th Thursday, October 1st
[3] Muscle Wednesday, September 30th Monday, October 5th
[4] Homeostasis Friday, October 16th Thursday, October 22nd
[5] Blood Friday, October 23rd Thursday, November 5th
[6] The Heart Friday, November 6th Thursday, November 12th
[7] Blood Vessels & Hemodynamics Friday, November 20th Thursday, November 26th
[8] Lymphatic System & Respiratory
Friday, November 27th Thursday, December 3rd
Anatomy
[9] Respiratory Physiology Thursday, December 3rd Wednesday, December 9th
All due dates are final. For the Mastering A&P assignments there is a penalty is 2% for each hour late. All
assignments are available as study aids until the end of the final exam period. Note that there is also an introductory
Mastering A&P assignment that is available to everyone but really needs to be done only by those new to Mastering.
It does not count toward your final Mastering score but is a nice introduction to the course and the type of questions
you will encounter in the online assignments.

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OTHER IMPORTANT INFORMATON

Please examine key deadlines and the Faculty of Health Sciences regulations on minimum grades required. The Student
Academic Success Service (SASS) website (https://sass.uottawa.ca/en) is a great resource when looking for all the
services available to students.

Academic Integrity
Each student in this course is expected to abide by the academic regulations of the University of Ottawa. Any work
submitted by a student for academic credit must be the student's own work. You are encouraged to study together
and to discuss information and concepts covered in lecture with other students. However, during examinations, you
must do your own work. Talking or discussion is not permitted during the examinations, nor may you compare
papers, copy from others, or collaborate in any way. Any collaborative behavior during examinations may result in
failure of the exam, and may lead to failure of the course and University disciplinary action. Please carefully examine
regulations on academic fraud. The use of notes of any kind, textbooks, cell phones, laptops, or any other digital
equipment is not permitted during exams

Specific Objectives
1. Structural Organization of the Human Body (Dr. Savory)
1.1. Define anatomy and physiology and describe their subdivisions
1.1.1 Explain the principle of complementarity
1.2. Describe the levels of structural organization that make up the human body
1.2.1 Define: atom, molecule, organelle, cell, tissue, organ, and organ system; give an example of each &
localize each in the hierarchy of anatomical structure
1.3. Cells: summarize the major organelles and structures found in body cells

1.4. Tissues: describe the different tissues of the human body

1.4.1 Define tissue and demonstrate how the organization of cells into tissues contributes to overall
homeostasis
1.4.2 List the 4 primary types of tissues
1.4.3 Define epithelial tissue; list 6 functions associated with epithelia

Assignment #1 (Cells and Tissues) is due Thursday, Sept. 24th

2. Cellular Physiology of Nerve and Muscle (Dr. Russell)
2.1. Membrane Transport:
2.1.1. Describe the structure of the plasma membrane
2.1.2. Describe and differentiate among the various types of transport across the plasma membrane
2.1.3. Describe osmosis and explain its role in fluid homeostasis
2.2. Neurons:
2.2.1. Identify the different regions of the neuron and associate each region with the functions of reception,
propagation and transmission of nerve impulses
2.2.2. Explain the phenomena (diffusion of ions, types of ion channels) that are responsible for the electrical
activity of neurons (resting membrane potential and action potential)
2.2.3. Describe the factors that influence propagation of the action potential along an axon
2.2.4. Explain the mechanisms of synaptic transmission (synapse, post-synaptic potentials, synaptic
integration)

Assignment #2 (Membrane Transport & Neuron) is due Thursday, Oct. 1st

2.3. Muscles:
2.3.1. Describe the microscopic structure of skeletal muscle fibers and explain the cellular mechanisms of
excitation-contraction coupling
2.3.2. Describe the neuromuscular junction
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2.3.3. Describe the contractile properties of skeletal muscle (motor unit, isotonic & isometric contractions,
spatial & temporal summation, etc.)
2.3.4. Associate various muscle types with their metabolism and their speed of contraction and rate of fatigue
2.3.5. Compare the properties of smooth muscle with those of skeletal muscle

Assignment #3 (Muscle) is due Monday, Oct 5th

Midterm exam #1: Tuesday, October 6th

3. Homeostasis: Introduction to the Autonomic Nervous System and Endocrine System (Dr. Savory)
3.1. Define and identify the main characteristics of homeostasis
3.2. Nervous system:
3.2.1. Compare somatic and autonomic nervous systems
3.2.2. Compare the functional differences between the sympathetic and parasympathetic divisions of the
ANS
3.3. Endocrine system:
3.3.1. Distinguish between exocrine and endocrine glands, and localize the major endocrine glands
3.3.2. Describe the different structural classes of hormones and their mechanisms of action
3.3.3. Describe the functional organization of the hypothalamic-pituitary axis
Assignment #4 (Homeostasis) is due Thursday, October 22nd

4. Cardiovascular System (Dr. Savory)

4.1. Blood:
4.1.1. Describe the composition of blood (plasma & formed elements)
4.1.2. Erythrocytes:
4.1.2.1. Describe the structure and function of RBCs; structure and properties of hemoglobin
4.1.2.2. Describe erythropoiesis, mechanisms of control, and life cycle of erythrocytes
4.1.3.Hemostasis:
4.1.3.1. Explain the principal steps and justify the role of platelets and clotting factors in this process
4.1.3.2. Explain the fibrinolytic system and recognize the action of the major anticoagulants
4.1.4.Differentiate among the various blood types and explain the basis of transfusion reactions

Assignment #5 (Blood) is due Thursday, November 5th

4.2. The Heart:

4.2.1. Describe the internal and external anatomy of the heart
4.2.2. Trace the pathway followed by blood in both the pulmonary and systemic circuits
4.2.3. Describe the organization of the coronary circulation
4.2.4. Compare the physiological properties of cardiac muscle cells with those of skeletal muscle cells
4.2.5. Compare the electrical properties of contractile cardiac muscle cells with those of auto rhythmic cardiac
muscle cells
4.2.6. Explain how the intrinsic conduction system of the heart allows it to function as a pump.
4.2.7. Explain what is an ECG tracing and the nature of the information it is providing
4.2.8. Explain the events occurring during each phase of the cardiac cycle
4.2.9. Define cardiac output in terms of heart rate and stroke volume
4.2.10. Describe in detail the mechanisms for the regulation of heart rate & stroke volume

Assignment #6 (The Heart) is due Thursday, Nov. 12th

Midterm exam #2: Tuesday, November 17th

4.3. Blood vessels and hemodynamics:
4.3.1. Compare and contrast the structure of the walls of arteries, capillaries and veins
4.3.2. Compare the 3 types of arterial vessels

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4.3.3. Define microcirculation and compare the three types of capillaries

4.3.4. Describe the structure and functions of the venules and veins
4.3.5. Define blood flow, blood pressure, resistance, peripheral resistance
4.3.6. Illustrate the changes in blood pressure throughout the various vessels of the circulatory system
4.3.7. Explain the factors that affect resistance and justify the importance of arterioles in the control of peripheral
resistance
4.3.8. Define systolic and diastolic arterial pressure, pulse pressure and mean arterial pressure
4.3.9. Identify and justify the value for mean capillary blood pressure
4.3.10. Express blood pressure in terms of cardiac output and peripheral resistance
4.3.11. Describe the short-term neural and chemical mechanisms for the regulation of blood pressure
4.3.12. Describe the role of the kidneys in the long-term regulation of blood pressure
4.3.13. Define and explain the mechanisms of autoregulation with regard to local blood flow
4.3.14. Explain the forces that act to influence capillary exchange
4.3.15. Identify the principal arteries and veins of the cardiovascular system: You will be responsible for arteries
and vein up to the level of the wrist and ankle, to each organ and to the brain (to and including the circle
of Willis). If you begin early and review often, then you will find it is not as daunting as it looks. However,
there will be little “learning time” during the lectures, so it will be up to you to put in the time.

Assignment #7 (Blood Vessels) is due Thursday Nov. 26th

5. The Lymphatic System (Dr. Savory)

5.1. Describe the structure and main functions of the vessels and organs of the lymphatic system
5.2. Explain the origin of lymph as well as its transport

6. The Respiratory System (Dr. Savory)

6.1. Describe the structures of each one of the components of the conduction and respiratory zones
6.2. Describe the gross structure of the lungs & the pleural coverings

Assignment #7 (Lymphatic System & Respiratory Anatomy) is due Thursday, Dec 3rd

6.3. Define & explain the following: intrapulmonary, intrapleural & transpleural pressures
6.4. Explain the roles of the diaphragm & accessory muscles during inspiration & expiration (quiet & forced)
6.5. Explain the 3 factors that influence pulmonary ventilation
6.6. Describe how lung volumes & capacities are measured; indicate their physiological significance
6.7. Define dead space and indicated its importance in minute and alveolar ventilation
6.8. Explain the mechanisms underlying the non-respiratory air movements
6.9. State Dalton’s Law and use it to describe the composition of atmospheric and alveolar air
6.10. Explain the factors that influence the movement of gases at the air-liquid interface
6.11. List and describe 3 factors that influence the exchange of air and carbon dioxide (lungs)
6.12. Describe the partial pressure gradients that drive oxygen and carbon dioxide movement (tissues)
6.13. Describe completely the transport of oxygen in the blood
6.14. Explain the sigmoidal nature of the oxygen-hemoglobin dissociation curve
6.15. Describe completely the 3 ways in which carbon dioxide is transported in the blood
6.16. Explain the Bohr and Haldane effects
6.17. Associate carbon dioxide levels with blood pH; explain how respiration can regulate blood pH
6.18. Describe how respiration is controlled by the nervous system
6.19. Indicate the effects of the following factors on respiration: Hering Breuer reflex, hypothalamus, cortex
6.20. List the 3 principal chemical factors that influence respiration and explain their mechanisms of action
6.21. Discuss the mechanisms controlling respiration during intense exercise

Assignment #8 (Respiratory Physiology) is due Wednesday, December 9th

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