OMEPRAZOLE (PRILOSEC)
A Drug Study Presented to the Faculty
of the Nursing Department
Verlen S. Cabaltica, RN
In Partial Fulfillment of the
Requirements in NCM – 212
META/ENDO/GI Nursing Rotation
By
Quinones, Tanya Angela M., St. N
BSN – 3C | Group 3
April 26, 2021
Generic Name Omeprazole
Brand Name Prilosec
Drug Classification Omeprazole is in a class of drugs called proton
pump inhibitors (PPI) that block the production of
acid by the stomach.
Mechanism of Action Reduces Gastric Acid Secretion and increases
Gastric mucus and bicarbonate production,
creating protective coating on gastric mucosa and
easing discomfort from excess gastric acid.
Suggested Dose Duodenal Ulcer
20 mg PO qDay for 4-8 weeks
Helicobacter Pylori Infection
Various regimens exist of PPIs combined with
antibiotics, example:
20 mg PO q12hr for 10 days, WITH
Amoxicillin 1000 mg PO q12hr, AND
Clarithromycin 500 mg PO q12hr for 10-14 days
Gastric Ulcer
40 mg PO qDay for 4-8 weeks
GERD
20 mg PO qDay for 4 weeks
Erosive Esophagitis
20 mg PO qDay for 4-8 weeks
Maintenance: 20 mg PO qDay for up to 1 year
Hypersecretory Conditions (eg, Zollinger-
Ellison Syndrome)
60 mg PO qDay (initial) up to 360 mg/day divided
q8hr PO If dose >80 mg, divide it
Indications Oral capsule is used to reduce the amount of acid
in your stomach. It's used to treat gastric or
duodenal ulcers, gastroesophageal reflux disease
(GERD), erosive esophagitis, and hypersecretory
conditions. This drug is also used to treat stomach
infections caused by Helicobacter pylori bacteria.
Contraindications Omeprazole is contraindicated in patients with a
history of hypersensitivity to the drug or dosage
form. It is also contraindicated in patients taking
dosage forms containing rilpivirine
Side Effects Omeprazole like other proton pump inhibitors is
well-tolerated. The most common side effects are
diarrhea, nausea, vomiting, headaches, rash and
dizziness. Nervousness, abnormal heartbeat,
muscle pain, weakness, leg cramps, and water
retention occur infrequently.
Adverse Reactions Severe allergic reactions (rash; hives; itching;
difficulty breathing; tightness in the chest; swelling
of the mouth, face, lips, or tongue; unusual
hoarseness); bone pain; chest pain; dark urine;
fast, slow, or irregular heartbeat; fever, chills, or
sore throat; red, swollen, blistered, or peeling skin;
severe diarrhea; severe stomach pain or cramps;
swelling of the hands, ankles, or feet; unusual
bruising or bleeding; unusual tiredness; vision
changes; yellowing of the eyes or skin.
Drug Interactions Omeprazole potentially can increase the
concentrations in blood of diazepam (Valium),
warfarin (Coumadin), and phenytoin (Dilantin) by
decreasing the elimination of these drugs by the
liver. The absorption of certain drugs may be
affected by stomach acidity. Therefore,
omeprazole as well as other PPls reduce the
absorption and concentration in blood of
ketoconazole (Nizoral) and increase the
absorption and concentration in blood of digoxin
(Lanoxin). This may reduce the effectiveness of
ketoconazole or increase digoxin toxicity.
Nursing Responsibilities 1. Assess Hypersensitivity to omeprazole or
any of its components; pregnancy, lactation
2. Instruct client to swallow capsules or
tablets whole and no to chew or crash
them.
3. Assess Vital Signs
4. Check for abdominal Pain, emesis,
Diarrhea or constipation.
5. Administer antacids with omeprazole, if
needed.
6. Evaluate fluid and intake.
7. Watch for elevated liver function test
results.
8. Caution patient to avoid driving and other
hazardous activities until he/she know drug
effects concentration and alertness.
9. Advice client to have regular medical
follow-up visits.
10. Instruct client to report if experiencing
severe headache, worsening of symptoms,
fever, and chills.
Reference MedicineNet. Omeprazole (Prilosec, Zegerid) Side
effects & Dosage. Retrieved April 26, 2021 from
https://www.medicinenet.com/omeprazole/article.h
tm#what_is_omeprazole_and_how_does_it_work
_mechanism_of_action
WebMD (2021). Omeprazole Oral: Uses, Side
Effects, Interactions. Retrieved April 26, 2021
from https://www.webmd.com/drugs/2/drug-3766-
2250/omeprazole-oral/omeprazole-delayed-
release-tablet-oral/details
