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Drug Name Mechanism of Action Indication/ Contraindication Adverse Effect Nursing Responsibilities

This document summarizes information about the drug Celecoxib (Celebrex), including its mechanism of action, indications, contraindications, and adverse effects. It selectively inhibits the enzyme COX-2 to reduce inflammation and relieve pain. It is indicated for osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, ankylosing spondylitis, acute pain, and primary dysmenorrhea. Contraindications include allergies to aspirin or NSAIDs. Common adverse effects involve the central nervous system, cardiovascular system, and ears, eyes, nose and throat. Nursing responsibilities include assessing dosage, monitoring for adverse effects, and instructing discontinuation if they occur.

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43 views1 page

Drug Name Mechanism of Action Indication/ Contraindication Adverse Effect Nursing Responsibilities

This document summarizes information about the drug Celecoxib (Celebrex), including its mechanism of action, indications, contraindications, and adverse effects. It selectively inhibits the enzyme COX-2 to reduce inflammation and relieve pain. It is indicated for osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, ankylosing spondylitis, acute pain, and primary dysmenorrhea. Contraindications include allergies to aspirin or NSAIDs. Common adverse effects involve the central nervous system, cardiovascular system, and ears, eyes, nose and throat. Nursing responsibilities include assessing dosage, monitoring for adverse effects, and instructing discontinuation if they occur.

Uploaded by

Johnrick Ventura
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© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Drug Name Mechanism of Action Indication/ Contraindication Adverse effect Nursing Responsibilities

Generic Name:  Selectively inhibits the Indication: CNS: Dx:


Celecoxib enzymatic activity of  To relieve signs and symptoms Aseptic meningitis, cerebral a. Check doctors order
cyclooxygenace-2 (COX -2), the of osteoarthritis hemorrhage, depression, dizziness, b. Assess pain score
Brand Name: enzyme needed to convert  To relieve signs and symptoms fever, headache, insomnia, ischemic c. Assess history of allergies
Celebrex arachidonic acid to of rheumatoid arthritis stroke, stroke, suicidal ideation, Tx:
prostaglandin. Prostaglandin are  To relieve signs and symptoms syncope, transient ischemic attack, a. Give drug with food, milk
Class: responsible for mediating the of juvenile rheumatoid arthritis vertigo or antacids
Diaryl-Substituted pyrazole inflammatory response and  To relieve pain from ankylosing b. Do not increase or double
derivative causing local vasodilation, spondylitis CV: dose; follow exactly as
swelling, and pain. Prostaglandin  To manage acute pain, to treat Aortic valve incompetence, chest prescribed and indicated
Therapeutic: also play a role in peripheral primary dysmenorrhea pain, congestive heart failure, deep c. Discontinue drug promptly
Anlagesic, Anti-inflammatory, pain transmission to the spinal  Management of acute pain vein thrombosis, fluid retention, if diarrhea. Dark stools.
antirheumatic cord. By inhibiting COX-2 hypertension, MI, palpitation, Hematemesis, ecchymosis,
activity and prostaglandin peripheral edema or gangrene, sinus epistaxis or rash occur and
Pharmacologic: production, this reduces Contraindication: bradycardia, tachycardia, do not use again. Contact
Cyclooxygenase-2 inhibitor inflammatory symptoms and  Allergic reaction (such as thrombosis, unstable angina, physician
relieves pain. anaphylaxis or angioedema) to vasculitis, hypertrophy
Dosage: aspirin, other NSAIDs, or Edx:
Source: Learning, J, Learning, B. sulfonamide derivatives or EENT: a. Document accordingly
Route: (2019). Nurse’s Drug Handbook history of aspirin-induced nasal b. Monitor for adverse effect
(8th edition). p220 polyps with bronchospasm; c. Instruct discontinuation of
hypersensitivity to celecoxib or medication if adverse effect
its components; treatment of occurs
pain after coronary artery
bypass graft surgery

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