The next step on

Magnetic Hyperthermia research

A closer look to the differences that make DM100 Series
your only choice on induction heating of nanomaterials
and hyperthermia devices.
 Study of the geometry of the field.
A serious approach. Just like your research.

The magnetic field The results of an experiment are heavily dependent on the geometry of the inductor that generates the
magnetic field, and of the point at which the sample is placed, since the intensity of the field is
not uniform within the inductor which generates it. In general, manufacturers and users
assume that the sample is exposed to a specific field, independent of where it is
placed within the region designed to hold the sample.

The errors caused by this assumption invalidate the conclusions in

On which most cases, especially in SAR and in vivo experiments as there

is no documented correlation between the stated and the real
field values.

all else rests... nB characterizes and documents the field geometry

of each and every induction coil so that the user
knows in detail the field applied in each case
and in this way widen the range of validity of
their conclusions.
In hyperthermia and inductive heating in general, each of the
conclusions presented in a scientific work or in industrial development
seeks to correlate the observed effects with the field applied to the
sample or subject in the study. A detailed and documented knowledge Mechanical stability.
of the field plays a fundamental role in these experiments and it is
the foundation on which the validity of our experimental conclusions
Robust construction for
is based. reliable readings.

In an inductive heating experiment, the magnetic field is generated The distribution and intensity of the
by means of an induction coil or inductor. Many factors affect the applied field are heavily dependent on
determination of the field applied by the inductor in each case; a fact the geometry of the coil. For this reason,
systems with interchangeable parts or with
which is forgotten by manufacturers and users of experimental inductive
coils exposed to the exterior of the device
heating equipment. put at risk the repeatability of an experiment
and the validity of the field readings, as these
nB’s DM100 Series offers a wide range of options of frequency and have been exposed to geometric variations due
field intensity and is the first system to back up field readings with to handling.
technology which is up to the task. In the applicators of the DM100 Series, the field
coils are protected and characterized when working
in order to guarantee reliability.

Electrical stability.
Measurement. A new technology for magnetic field control
A well known and trusted field value. for a new area of knowledge.

There are several reasons why the intensity of the applied field may vary during
The intense field generated in the region of application does not allow an electronic system to measure the field
an experiment, or between one experiment and another. An induction system undergoes
directly in any reliable way, largely because the use of Hall transducers, sensing coils or any electronic transducer
modifications in its physical constants during an experiment due to the high demands placed on it by the
in a high intensity alternating magnetic field leads to errors which generally invalidate the measurements.
temperature, current and tension to which it is exposed, as well as by environmental causes.
To solve this problem, most manufacturers suggest that the applied field be determined by using simplified
This means that the field generated is not constant over time if these variations are not compensated for.
formulae taken from electromagnetic physics. But the intensity of the magnetic field is not equal in all the points
Systems for hyperthermia that depend on other manufacturers as an energy source or frequency generator do
of the interior region of a field coil. These formulae not only give only one single numerical value (instead of a
not compensate for these variations. Also, inductive heating systems from the world of metallurgy in general
spatial distribution within the field) but are often used well outside the range of their validity, causing errors of
control the power supplied, and not the inductor field, which is no guarantee of a constant field. Both these
up to 50% in estimating the field. This is perhaps the most frequent source of errors committed in magnetic
deficiencies endanger the validity of the measurements and put the integrity of the samples at risk.
inductive heating experiments.
The DM100 Series devices carry out checks in real time of the applied field by means of an algorithm
The applicators of the DM100 Series use an indirect measuring method in real time, which, backed up by the
and technology specially designed for field applicators for use with nanostructured systems. A specific
stability and attention to detail of each component, guarantees a precision which is unique in the market.
technology for a new area.
Measuring Power and reliability.

Temperature
The best tool for characterizing.

The DM100 applicators not only ensure the best and

most precise fields on the market – they also offer the
best thermal insulation for calorimetric experiments.

This makes for clearer and more reliable heating

The right way

curves which you would find on no other commercially
available or experimental instrument.

The measurement of physical

variables in the presence of alternatig
field of great intensity throws up a
series of instrumental challenges. Insulation.
The technology of the sensors and The secret of calorimetry.
the design of the system’s thermal
isolation are the foundations of good
In calorimetric experiments it is essential to be able
measurement. to count on the best possible insulation. Insulation
is not only important because it diminishes heat loss
Both the DM1 applicators for generated by the sample, but also because it stops the
calorimetry and the other applicators sample being heated by external heat sources, such as
of the DM100 Series are equipped the induction coil and the electronics.
with temperature sensors born of a Also, the smaller the sample, the more important
technology developed specifically the insulation. For this reason, the DM1 is equipped
for each application and a thermally to deal with adjustable volumes (starting at 500 μl
controlled and characterized ) depending on the user’s requirements, in a dewar
flask with connection for vacuum pump, in order
environment. to guarantee the best possible insulation, thereby
providing much better performance than closed dewar
Attention to detail and to every technical aspect makes for a system systems or systems of solid insulation via foams and
which is unique in the market. The right way of measuring temperature. other materials.

Sensors. Repeatability.
A reliable witness. The scientific method.

Whether for calorimetry, in vivo or in vitro experiments, for clinical application or experiments on new materials, In calorimetric experiments we try to correlate as best as possible the applied field with the increase
in situ temperature measurement is an essential tool in all inductive heating development. in temperature. The intensity of the field within the induction coil is not uniform, and in short coils,
such as those used in inductive heating, the intrinsic divergence can be as much as 40%.
In the selection process for sensors, it is believed that only so-called “ferromagnetic” materials are affected
by magnetic fields. This is false: this simplification of the problem gives rise to serious weaknesses in many A simple but effective sample-holder design, and the careful construction of the region of application
temperature measuring systems in induction experiments. All the macroscopic metallic parts produce heat guarantee the DM1 user an applied field which can be repeated in the long term for different tests,
which corrupts the measurements, as do electronic semiconductor systems and in general any cable or electrical samples and methods, thereby widening the range of validity of its conclusions.
connection causes noise and signal biasing which should be excluded from the measuring process.
The repeatability of tests today brings us closer to knowledge of the universe tomorrow.
The DM100’s temperature measuring system uses fibre optic sensors – a proven technology, which is free
of electric currents and extremely precise. But this isn’t the only advantage: the DM1 sensor is unique in
the market, specially adapted for magnetic colloids, with small thermic mass as well as contamination-proof
constructions. The DM1 will not let the remains of previous samples contaminate your current one and its
sensors, thereby protecting your experiment from yet another source of error.
Productivity Versatility
The time value of your New forms for new ideas
research ideas The DM100 Series is designed modularly, in order to take in each step of the research both for
today and for the future of your projects. Each applicator is constructed for a specific type of
experiment, while leaving space for modifications or the addition of made-to-order accessories and
The DM100 Series has been designed to optimise special characteristics.
productivity in the lab. MANIAC, the software embedded
in the system’s controller, is unique in its class and was
developed by nB taking into account every step of its work.

Many labs take months, even years to fine-tune an inductive

heating system, which can be very exciting, but even much
more expensive in terms of money and time, and can
relegate you to the bottom in the race for new results.

With MANIAC running on a DM100 system, you will not

need a qualified technician to look after your inductive
heating system. Nor will you or your co-workers need to be
an instrumentation specialist. DM100 is the complete tool
for your lab, and MANIAC is your lab assistant.

DM100 cuts the distance between you and your

experimental results.

Performing individual tests up work flow in the lab. MANIAC is a flexible and Versatile sample-holders teeing precision of the applied field and freeing up
MANIAC allows you to carry out inductive heating powerful work station which adapts to each experiment The sample-holder of each DM100 Series applicator the user to perform other tasks for the operation or
tests in a matter of seconds. Using “test” mode, and makes the researcher’s daily life easier. adapts itself to the experiment for which it was de- monitoring of the process.
an automatic field application can be started and signed. Both the calorimetry vials of the DM1 as well
controlled just by indicating the field values you wish Depending on the available options, MANIAC can as each of the accessories made for different types of What’s more, the DM100 applicators can be confi-
to attain. calculate a sample’s SAR, make graphic presentations experiments are characterized and optimised in order gured to order according to the required frequency
and statistical charts and is open to tailor-made to obtain the best performance for volume and for with up to 8 frequency applications available in each
designs and future modifications in accordance with uniformity of field. applicator, ranging from 50KHz to 1MHz.
Programming complex tests the researcher’s needs.
One important characteristic of MANIAC is that it
is able to carry out complex tests made up of fields Of all the applicators, the DM2 is the most versatile
of different characteristics, with pre-set intervals Remote control in the DM100 Series to date. Its ample sample-hol-
Safety
of time and even to control them through different MANIAC, and therefore the whole DM100 system, can ding slot allows for the widest range of experiments to
Inductive heating systems are often constructed with
parameters. A versatile tool for trying out new ideas. be operated remotely via Ethernet. You can acccess be designed, either in the basic version or accompa-
the coil exposed to the outside or with very rudimen-
the readings of an experiment in real time from your nied by sample-holder accessories which are adapted
tary protection, leaving matters of skill and of safety
office or use the result analysis tools without having for different test conditions. Whether you need series
Data registration in the hands of the user.
to install software on your computer, so you can work options or made to measure kit, nB can offer you the
MANIAC keeps you informed in real time about the devices that your project needs.
the way you want to independently of the operative This limits the user’s freedom of operation and,
data registered during the experiment. Both the field
system you are using. furthermore, puts them in bodily danger of electric
characteristics as well as variations measured in the
sample are shown on screen, while they are filed shocks or burns.
With the appearance of new techniques of synthesis Variable frequency and intensity
away together with all the other test data. MANIAC
and manipulation of nanoparticles, applications for With DM100 it is possible to choose and automate All the applicators of the DM100 Series are construc-
is compatible with USB storage devices, which allows
induction heating have multiplied to open out a new the intensity of the application of the field in each ted to guarantee the user the highest possible level
you to manage all the files in standard format.
horizon which takes in a great many areas. Among experiment with total flexibility and a maximum in- of safety in each application. Not only are the coils
them, that which has attracted the most attention is tensity – according to the model – of up to 600 Oe. protected in the interior of the applicator, but also the
Analysis of Results without doubt that of biomedical applications, which MANIAC, the software which is embedded in the system is set up to sense in real time that the liquid
Each applicator has an option for additional software take in the treatment of cancer, drug delivery, and system’s controller allows the user to programme ex- refrigeration, temperature of the sample and all elec-
with tools for analyzing experiments, which can speed contrast agents, among other things. periments and carry them out automatically, guaran- trical variations are kept within safe limits.
 One of the main problems encountered at the start of a new area of research is that specifically
designed tools are not yet available. For many years, any laboratory which was interested in studying
the applications of the inductive heating of nanostructured materials had to manufacture their own
induction equipment, with the consequent loss of time, money and human resources, and with
varying results.

Whether making an integral construction of an original system, or adapting an industrial induction

system, the research group faces a host of problems regarding instrumentation which complicate the
whole process and may make the validity of the experimental results obtained open to question.

The combination of the scientific leadership of the Magnetic Hyperthermia Group of the Institute of Nanosciences of Aragon (Spain) and
the thorough work of nB nanoScale Biomagnetic’s team of R+D engineers has created the DM100 Series – the first integral, specific and
reliable instruments designed for the study of applications of inductive heat to nanostructured materials.

The applicators of the DM100 Series mark a vast improvement in measurement and in laboratory productivity, and offer the right tool for
an area that was in need of it.

Here we go over the key aspects of an instrument designed for inductive heating experiments in the lab and explain why the DM100 is the
only choice on the market which is up to the demands of your research projects.

Power and reliability

The best tool for characterizing
The DM100 applicators not only ensure the best and most precise fields on the market – they also offer the best thermal
insulation for calorimetric experiments. This makes for clearer and more reliable heating curves which you would find on no
other commercially available or experimental instrument.

DM1 can generate a huge amount

of heat in your samples and pre-
serve it in just a few seconds. All
of it by means of a simple software
operation, with no previous cali-
bration or assembly of parts.

Thanks to the exclusive software

MANIAC, the DM100 applicators
can generate analytic reports for
each specific type of experiment,
saving time and preventing from
data handling related errors.