Scribd Logo
Upload

Welcome to Scribd!

  • 355 views

    Predict 1 & 2 Overview

    Uploaded by

    UncoverDC
    This document discusses building capacity for pandemic prevention using a One Health approach. It proposes targeted surveillance of animals like primates, bats, and birds in areas where human activities increase contact. The approach involves sampling animals and humans, testing samples for known and novel viruses using PCR and sequencing, and reporting results to authorities. It had success in the past by sampling over 56,000 animals, developing diagnostic methods, and detecting 984 viruses. The new focus is proposed to identify drivers of high-risk human behaviors and pathways for disease emergence, with targeted surveillance of wildlife, livestock, and humans. A One Health policy aim is to validate approaches through collaborative evidence gathering and promote policies that reduce virus spread.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    Predict 1 & 2 Overview

    Uploaded by

    UncoverDC
    355 views34 pages
    This document discusses building capacity for pandemic prevention using a One Health approach. It proposes targeted surveillance of animals like primates, bats, and birds in areas where human activities increase contact. The approach involves sampling animals and humans, testing samples for known and novel viruses using PCR and sequencing, and reporting results to authorities. It had success in the past by sampling over 56,000 animals, developing diagnostic methods, and detecting 984 viruses. The new focus is proposed to identify drivers of high-risk human behaviors and pathways for disease emergence, with targeted surveillance of wildlife, livestock, and humans. A One Health policy aim is to validate approaches through collaborative evidence gathering and promote policies that reduce virus spread.

    Original Description:

    Andrew Huff/Former EcoHealth Scientist

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    This document discusses building capacity for pandemic prevention using a One Health approach. It proposes targeted surveillance of animals like primates, bats, and birds in areas where human activities increase contact. The approach involves sampling animals and humans, testing samples for known and novel viruses using PCR and sequencing, and reporting results to authorities. It had success in the past by sampling over 56,000 animals, developing diagnostic methods, and detecting 984 viruses. The new focus is proposed to identify drivers of high-risk human behaviors and pathways for disease emergence, with targeted surveillance of wildlife, livestock, and humans. A One Health policy aim is to validate approaches through collaborative evidence gathering and promote policies that reduce virus spread.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    355 views34 pages

    Predict 1 & 2 Overview

    Uploaded by

    UncoverDC
    This document discusses building capacity for pandemic prevention using a One Health approach. It proposes targeted surveillance of animals like primates, bats, and birds in areas where human activities increase contact. The approach involves sampling animals and humans, testing samples for known and novel viruses using PCR and sequencing, and reporting results to authorities. It had success in the past by sampling over 56,000 animals, developing diagnostic methods, and detecting 984 viruses. The new focus is proposed to identify drivers of high-risk human behaviors and pathways for disease emergence, with targeted surveillance of wildlife, livestock, and humans. A One Health policy aim is to validate approaches through collaborative evidence gathering and promote policies that reduce virus spread.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 34
    At a glance
    Powered by AI
    The key takeaways are that zoonotic diseases are often of animal origin, human activities at the wildlife interface can lead to disease emergence, and a One Health approach is needed to address these issues.

    The One Health approach recognizes the interconnectedness of human, animal and environmental health. It aims to achieve optimal health outcomes by bringing together multiple disciplines like human and veterinary medicine, and is important for addressing diseases of animal origin that impact human health.

    PREDICT collects samples like oral swabs, rectal swabs, feces, urine and blood from animals like primates, bats, rodents and birds. They perform diagnostic tests like PCR and viral sequencing to detect known and novel viruses in these samples.

    PREDICT:

    Building capacity to prevent


    pandemics using a One Health
    approach
    The Challenge

    Pre-empt or combat, at their source, the first


    stage of emergence of zoonotic diseases that
    pose a significant threat to public health
    (potentially pandemic infections)
    Emerging Infectious Diseases

    • Majority are of animal origin


    (zoonotic)

    • 75% of emerging zoonoses have


    wildlife origins

    • Human activities at the interface are


    linked to EIDs (Nipah virus, SARS,
    Ebola)

    • Annual population growth among


    highest in buffers to protected areas
    near wildlife
    Emerging Infectious Diseases
    One Health Approach

    Animals

    Humans
    Environment
    Hot Spots 2
    Targeted, Risk-based Surveillance
    Targeted, Risk-based Surveillance

    • Primates
    • Bats
    • Rodents
    • Birds
    • Suids
    • Carnivores
    • Ungulates
    • Humans
    Work Flow
    • Conventional PCR –
    • Oral Swab
    Viral Family testing
    • Rectal Swab or Feces
    • Urine sample
    • Blood Sample • Sequencing

    • Interpretation

    • Report to Authorities
    • Approval of Results
    • Guidance for Policy
    • Analysis and Modeling
    Work Flow
    • Conventional PCR –
    • Oral Swab
    Viral Family testing
    • Rectal Swab or Feces
    • Urine sample
    • Blood Sample • Sequencing

    • Interpretation

    • Modify methods
    • Report to Authorities
    • Approval of Results
    • Guidance for Policy
    • Analysis and Modeling
    Safely Sampled More than 56,000 Animals
    Developed & Operationalized Diagnostic Platform
    Laboratory Capacity Building

    • Trained 32
    laboratories
    globally
    • 27 screening for
    targeted viral
    families
    Ran Over 400,000 Diagnostic Tests
    Viral Detection Success

    Overall 984 known and new viruses:


    • 812 novel and 147 known in animals
    • 3 novel and 31 known in human pilot studies
    Outbreak Investigations
    With Governments: Making Data Available to the Public
    PREDICT-2 Focus

    Identify large-scale
    trans-boundary
    ecological processes
    underlying human
    activities at high-risk
    interfaces

    Characterize pathways
    for disease emergence
    PREDICT-2 Focus

    Target Biological
    Sampling on:
    Wildlife
    Livestock
    People

    Behavioral Risk
    Assessment

    In support of mitigation
    Behavioral Risk Surveillance Strategy
    • GOAL: To identify drivers of specific behaviors/practices
    that lead to viral spillover and potential targets for
    mitigation
    • How accomplished?
    – Rapid, targeted 4-8 week in-depth qualitative
    research in DRC, Cameroon, Uganda, Indonesia,
    China, Bangladesh
    • Fill in knowledge gaps
    • Inform behavioral survey for higher data quality
    – Develop behavioral risk survey
    • Informed by qualitative data, EPT-1 research and published
    manuscripts
    • Pilot tested in countries with no in-depth qualitative research
    • Administered in as many countries as possible

    – Concurrent biological sampling and behavioral risk


    survey/rapid questionnaire (Interim tool to be used
    first)
    – Focus on highest risk sites for risk mitigation

    Pending discussion with local partners and authorities


    Qualitative Research

    Observational
    assessment=
    Human
    Environment
    Focus Groups=
    Community Life

    Ethnographic
    Interviews=
    Individual &
    Household
    Targeted, Risk-based Training & Surveillance
    Targeted, Risk-based Surveillance

    • Camels
    • Bats
    • Humans
    Scientific Strategy: Viral Families

    • Coronaviruses
    • Influenza’s
    • Parainfluenza’s
    • Filoviruses
    • Others if possible

    • SARI – ILI - FUO


    Scientific Strategy: Virus Risk
    Expanded characterization of viruses with epidemic and
    unknown pandemic potential combined with risk assessment

    Spillover risk
    Pandemic risk
    One Health Policies/Practices
    Promoting policies and practices that reduce the risk of virus
    evolution, spillover, amplification, and spread

    • Collaboration with The World Bank – building an evidence base for One
    Health

    • Proposal to hold ‘Phase II’ workshop in partnership with World Bank (likely
    in a future year)

    • Oriented toward policy change

    • One Health assessment and investment criteria

    Objective 5: Validating One Health Approaches


    One Health Policies/Practices

    Validating One Health Approaches

    2011- 2012 Workshop and Report

    Objective 5: Validating One Health Approaches


    One Health Policies/Practices
    Conduct a systematic and dedicated effort to validate and evaluate
    the utility of One Health approaches using all available evidence
    Preventive/Early Warning Reactive

    Monitoring/early Response/Control: $$$


    detection: $
    Health burden:
    Health burden: DALYs
    DALYs

    Deaths: 49 Deaths: 9,500+

    Duration: <90 days Duration: >460 days

    Perceptions: Perceptions:
    Confidence in Vulnerability fears and
    preparedness lack of predictive value
    infrastructure
    Operations:
    Operations: Multidisciplinary; Sole-discipline; limited
    inclusive (all gender, income) population integration

    Objective 5: Validating One Health Approaches


    WHERE we are working
    Geographic Focus
    Asia* Africa* Africa*
    Bangladesh Cameroon Republic of Congo
    Cambodia Cote d’Ivoire Rwanda
    China DR Congo Senegal
    Lao PDR Egypt Sierra Leone
    India Ethiopia Sudan
    Indonesia Gabon South Sudan
    Nepal Ghana Tanzania
    Malaysia Guinea Uganda
    Mongolia Kenya
    Myanmar Liberia M.E.*
    Philippines Jordan
    Thailand
    Vietnam
    *In-country locations TBD based on identification of target
    epizones and transmission pathways
    PREDICT-2 Partners
    Consortium Partners:
    EcoHealth Alliance, Metabiota, Smithsonian Institution, UC Davis,
    Wildlife Conservation Society
    Global Partners:
    CDC, EPT One Health Workforce, EPT Preparedness & Response, FAO, WHO,
    DTRA, Columbia University, HealthMap, UC San Francisco
    Implementing Partner Examples (in addition to consortium partners):
    Africa: Institut National de Recherche Biomedical, Mountain Gorilla Veterinary
    Project, Inc., Sokoine University of Agriculture
    Asia: Center for Molecular Dynamics Nepal, Chulalongkorn University, East
    China Normal University, ICCDR-B, Institut Pertanian Bogor, Institut Pasteur du
    Cambodge
    Host country and regional partner Examples:
    Ministries of Agriculture, Health, Livestock, Wildlife, and associated
    Departments; USAID missions; and relevant host country laboratories,
    universities, and research institutes (e.g. Institut Pasteur, Wuhan Institute of
    Virology, local CDCs, etc.)
    PREDICT - 2

    The Ministries of Health, Agriculture & Environment and


    Implementing University and NGO Partners in 31 Countries

    You might also like