Jntua 17 Regulation

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ACADEMIC REGULATIONS COURSE

STRUCTURE AND DETAILED SYLLABI
PHARM D
AND
PHARM D(POSTBACCALAUREATE)
PHARM D. (REGULAR SIX YEAR COURSE)

AND
PHARM D. (POST BACCALAUREATE) (REGULAR THREE
YEAR COURSE)
(APPICABLE FOR THE BATCHES ADMITED

FROM 2017-18)
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Doctor of Pharmacy (Pharm.D) Syllabus

Academic Regulations 2017 for Pharm. D and D (Post Baccalaureate) (Regular)
(Effective for the students admitted into I year from the Academic Year 2017-2018 onwards)
1. Award of Pharm. D Degree

A student will be declared eligible for the award of the Pharm. D. Degree if he/she fulfils the
following academic regulations:
i. Duration of the course. –
a) Pharm.D: The duration of the course shall be six academic years (five years of study and one
year of internship or residency) full time with each academic year spread over a period of not
less than two hundred working days. The period of six years duration is divided into two phases
–
Phase I – consisting of First, Second, Third, Fourth and Fifth academic year.
Phase II – consisting of internship or residency training during sixth year involving posting in
speciality units. It is a phase of training wherein a student is exposed to actual pharmacy practice
or clinical pharmacy services and acquires skill under supervision so that he or she may become
capable of functioning independently.
b)Pursue the course of study for not less than SIX academic years and is not more than
TWELVEyears.
c)Students, who fail to fulfil all the academic requirements for the award of the degree within
TWELVE academic years from the year of their admission, shall forfeit their seat in Pharm D.
course and their admission is cancelled.
2. A student will be declared eligible for the award of the Pharm. D (Post Baccalaureate).
Degree if he fulfils the following academic regulations:
a)Pharm.D. (Post Baccalaureate): The duration of the course shall be for three academic years
(two years of study and one year internship or residency) full time with each academic year
spread over a period of not less than two hundred working days. The period of three years
duration is divided into two phases –
Phase I – consisting of First and Second academic year.
Phase II – consisting of Internship or residency training during third year involving posting in
speciality units. It is a phase of training wherein a student is exposed to actual pharmacy practice
or clinical pharmacy services, and acquires skill under supervision so that he or she may become
capable of functioning independently.
b) Pursue the course of study for not less than THREEacademic years and is not more than SIX
years.

c) Students, who fail to fulfil all the academic requirements for the award of the degree within
SIX academic years from the year of their admission, shall forfeit their seat in Pharm D (PB)
course and their admission is cancelled.
3. Minimum qualification for admission to. –

a) Pharm.D. Part-I Course – A pass in any of the following examinations –
(1) 10+2 examination with Physics and Chemistry as compulsory subjects along with one of the
following subjects: Mathematics or Biology.
(2) A pass in D.Pharmacy course from an institution approved by the Pharmacy Council of India
under section 12 of the Pharmacy Act.
(3) Any other qualification approved by the Pharmacy Council of India as equivalent to any of
the above examinations. Provided that a student should complete the age of 17 years on or
before 31st December of the year of admission to the course. Provided that there shall be
reservation of seats for the students belonging to the Scheduled Castes, Scheduled Tribes and
other Backward Classes in accordance with the instructions issued by the Central
Government/State Government/Union Territory Administration as the case may be from time to
time.
b) Pharm.D. (Post Baccalaureate) Course - A pass in B.Pharm from an institution approved by
the Pharmacy Council of India under section 12 of the Pharmacy Act: Provided that there shall
be reservation of seats for the students belonging to the Scheduled Castes, Scheduled Tribes and
other Backward Classes in accordance with the instructions issued by the Central
Government/State Government/Union Territory Administration as the case may be from time to
time.
4. Courseof study. –
The course of study for Pharm.D. shall include the subjects as given in the Tables below. The
number of hours in a week, devoted to each subject for its teaching in theory, practical and
tutorial shall not be less than that noted against it in columns (3), (4) and (5) below.

COURSE STRUCTURE
First Year:
S.No. Subjects Name of Subject No. of No. of No. of Lab S.No. Subjects
Codes hours of hours of hours of codes
Theory Tutorial Practical
(1) (2) (3) (4) (5) (6) (7) (8)
1.1 17T00101 1 3 1.7 17T00107

Human Anatomy and
Physiology 3
1.2 17T00102 Pharmaceutics 2 1 3 1.8 17T00108
1.3 17T00103 Medicinal Biochemistry 3 1 3 1.9 17T00109
1.4 17T00104 1 3 2.0 17T00110

Pharmaceutical Organic
Chemistry 3
1.5 17T00105 1 3 2.1 17T00111
Pharmaceutical Inorganic
Chemistry 2
1.6 17T00106 Remedial Mathematics/ 3 1 3* 2.2 17T00112*
Biology
Total hours 16 6 = (40) 18

* For Biology

Second Year:
S.No Subjects Name of Subject No. of No. of No. of Lab S.No Subjects
Codes hours of hours of hours of Codes
(1) (2) (3) (4) (5) (6) (7) (8)
2.1 17T00201 Pathophysiology 3 1 - - -

2.2 17T00202 Pharmaceutical Microbiology 3 1 3  2.7 17T00207
2.3 17T00203 Pharmacognosy 3 1 3  2.8 17T00208

&Phytopharmaceuticals
2.4 17T00204 Pharmacology-I 3 1 - - -

2.5 17T00205 Community Pharmacy 2 1 - - -
2.6 17T00206 Pharmacotherapeutics-I 3 1 3  2.9 17T00209
Total Hours 17 6 = 32 9
Third Year:
S.N Subjects Name of Subject No. of No. of No. of Lab S.No Subjects
O Codes hours of hours of hours of Codes
(1) (2) (3) (4) (5) (6) (7) (8)
3.1 17T00301 Pharmacology-II 3 1 3  3.7 17T00307

3.2 17T00302 Pharmaceutical Analysis 3 1 3  3.8 17T00308
3.3 17T00303 Pharmacotherapeutics-II 3 1 3  3.9 17T00309
3.4 17T00304 Pharmaceutical Jurisprudence 2 - - - -
3.5 17T00305 Medicinal Chemistry 3 1 3  4.0 17T00310

3.6 17T00306 Pharmaceutical Formulations 2 1 3  4.1 17T00311
Total hours 16 5 = 36 15
5
Fourth Year:
S.N Subjects Name of Subject No. of No. of No. of Lab S.No Subjects
o. Codes hours of hours of hours of Codes
Theory Tutorial Practical/
Hospital
Posting
(1) (2) (3) (4) (5) (6) (7) (8)
4.1 17T00401 Pharmacotherapeutics-III 3 1 3  4.7 17T00407
4.2 17T00402 Hospital Pharmacy 2 1 3  4.8 17T00408
4.3 17T00403 Clinical Pharmacy 3 1 3  4.9 17T00409
4.4 17T00404 Biostatistics & Research 2 1 - - -

Methodology
4.5 17T00405 Biopharmaceutics & 3 1 3  4.10 17T00410
Pharmacokinetics
4.6 17T00406 Clinical Toxicology 2 1 - - -

For Pharm D Post Baccalaurate
4.11 14T00411 Pharmacotherapeutics I 3 1 3  4.12 14T00412

& II
18 7=39
Fifth Year:
S.N Subjects Name of Subject No. of hours No. of No. of

o. Codes of Theory hours of hours of
Seminar Hospital
posting*
(1) (2) (3) (4) (5) (6)
5.1 17T00501 Clinical Research 3 1 -

5.2 17T00502 Pharmacoepidemiology and 3 1 -
Pharmacoeconomics
5.3 17T00503 Clinical Pharmacokinetics & 2 1 -

Pharmacotherapeutic Drug Monitoring
5.4 Clerkship* - 1 -
5.5 Project work (Six Months) - - 20
* Attending ward rounds on daily basis.
Sixth Year:
Internship or residency training including postings in speciality units. Student should
independently provide the clinical pharmacy services to the allotted wards.
6
(i) Six months in General Medicine department, and

(ii) Two months each in three other speciality departments
5. Syllabus. – The syllabus for each subject of study in the said Tables shall be as
specified in Appendix -A to these regulations.
6. Examination. –
(1) Every year there shall be an examination to examine the students.
(2) Each examination may be held twice every year. The first examination in a year
shall be the annual examination and the second examination shall be supplementary
examination.
(3) The examinations shall be of written and practical (including oral nature) carrying
maximum marks for each part of a subject as indicated in Table below:
TABLES
First Year examination:
S.No Name of Subject Maximum marks for Theory Maximum marks for Practicals
Examin Sessional Total Examination Sessional Total
ation
1.1 Human Anatomy and 70 30 100 70 30 100
Physiology
1.2 Pharmaceutics 70 30 100 70 30 100
1.3 Medicinal Biochemistry 70 30 100 70 30 100
1.4 70 30 100 70 30 100
Pharmaceutical Organic
Chemistry
1.5 70 30 100 70 30 100
Pharmaceutical Inorganic
Chemistry
1.6 Remedial Mathematics/ 70 30 100 70 30 100
Biology
600 600 =
1200
Second Year examination:

Examination Sessiona Total Examination Sessional Total
l
2.1 Pathophysiology 70 30 - - -
2.2 Pharmaceutical 70 30 100 70 30 100
Microbiology
2.3 Pharmacognosy 70 30 100 70 30 100
&Phytopharmaceuticals
2.4 Pharmacology-I 70 30 100 - - -
2.5 Community Pharmacy 70 30 100 - - -
2.6 Pharmacotherapeutics-I 70 30 100 70 30 100
7
600 300 = 900

Third Year examination:
Examin Sessional Total Examinati Sessiona Total
ation on l
3.1 Pharmacology-II 70 30 100 70 30 100
3.2 Pharmaceutical Analysis 70 30 100 70 30 100
3.3 Pharmacotherapeutics-II 70 30 100 70 30 100
3.4 Pharmaceutical 70 30 100 - - -
Jurisprudence
3.5 Medicinal Chemistry 70 30 100 70 30 100
3.6 Pharmaceutical Formulations 70 30 100 70 30 100
600 500 = 1100
Fourth Year examination:
Examination Sessional Total Examination Sessiona Total
l
4.1 Pharmacotherapeutics- 70 30 100 70 30 100
III
4.2 Hospital Pharmacy 70 30 100 70 30 100
4.3 Clinical Pharmacy 70 30 100 70 30 100
4.4 Biostatistics & Research 70 30 100 - - -
Methodology
4.5 Biopharmaceutics & 70 30 100 70 30 100
Pharmacokinetics
4.6 Clinical Toxicology 70 30 100 - - -
600 500 = 1100
Fifth Year examination:
Examina Sessional Total Examinati Sessio Total
tion on nal
5.1 Clinical Research 70 30 100 - - -
5.2 Pharmacoepidemiology and 70 30 100 - - -
Pharmacoeconomics
5.3 Clinical Pharmacokinetics 70 30 100 - - -
&Pharmacotherapeutic Drug
Monitoring
5.4 Clerkship* - - - 70 30 100
5.5 Project work (Six Months) - - - 100** - 100
300 200 =
500
*Attending ward rounds on daily basis.
** 30 marks – viva-voce (oral)
70 marks – Thesis work
8
7. Attendance requirements: (Eligibility for appearing Examination) - Only such

students who produce certificate from the Head of the Institution in which he or she
has undergone the Pharm.D. or as the case may be, the Pharm.D. (Post Baccalaureate)
course, in proof of his or her having regularly and satisfactorily undergone the
course of study by attending not less than 80% of the classes held both in theory and
in practical separately in each subject shall be eligible for appearing at examination.
8. Mode of examinations
(1) Theory examination shall be of three hours and practical examination shall be of
four hours duration.
(2) A Student who fails in theory or practical examination of a subject shall re-appear
both in theory and practical of the same subject.
(3) Practical examination shall also consist of a viva –voce (Oral) examination.
(4) Clerkship examination – Oral examination shall be conducted after the completion
of clerkship of students. An external and an internal examiner will evaluate the
student. Students may be asked to present the allotted medical cases followed by
discussion. Students’ capabilities in delivering clinical pharmacy services,
pharmaceutical care planning and knowledge of therapeutics shall be assessed.
9. Award of sessional marks and maintenance of records.―

(1) A regular record of both theory and practical class work and examinations
conducted in an institution imparting training for Pharm.D. or as the case may be,
Pharm.D. (Post Baccalaureate) course, shall be maintained for each student in the
institution and 30 marks for each theory and 30 marks for each practical subject shall
be allotted as sessional.
(2) There shall be at least three periodic sessional examinations during each academic
year and the highest aggregate of any two performances shall form the basis of
calculating sessional marks.
(3) The sessional marks in practicals shall be allotted on the following basis:-
(i) Actual performance in the sessional examination (20 marks);
(ii)Day to day assessment in the practical class work,
promptness, viva-voce record maintenance, etc. (10 marks).
10. Minimum marks for passing examination.― A student shall not be declared to
have passed examination unless he or she secures at least 50% marks in each of the
9
subjects separately in the theory examinations, including sessional marks and at least
50% marks in each of the practical examinations including sessional marks. The
students securing 60% marks or above in aggregate in all subjects in a single attempt
at the Pharm.D. or as the case may be, Pharm. D. (Post Baccalaureate) course
examination shall be declared to have passed in first class. Students securing 75%
marks or above in any subject or subjects shall be declared to have passed with
distinction in the subject or those subjects provided he or she passes in all the subjects
in a single attempt.
11. Eligibility for promotion to next year.- All students who have appeared for all the
subjects and passed the first year annual examination are eligible for promotion to the
second year and, so on. However, failure in more than two subjects shall debar him or
her from promotion to the next year classes.
12. Internship.―
(1) Internship is a phase of training wherein a student is expected to conduct actual
practice of pharmacy and health care and acquires skills under the supervision so that
he or she may become capable of functioning independently.
(2)Every student has to undergo one year internship as per PCI norms for Pharm D
(Appendix B).
13. Certificate of passing examination.― Every student who has passed the
examinations for the Pharm.D. (Doctor of Pharmacy) or Pharm.D. (Post
Baccalaureate) (Doctor of Pharmacy) as the case may be, shall be granted a certificate
by the examining authority.
14. Hospital posting.― Every student shall be posted in constituent hospital for a
period of not less than fifty hours to be covered in not less than 200 working days in
each of second, third & fourth year course. Each student shall submit report duly
certified by the preceptor and duly attested by the Head of the Department or
Institution as prescribed. In the fifth year, every student shall spend half a day in the
morning hours attending ward rounds on daily basis as a part of clerkship. Theory
teaching may be scheduled in the afternoon.
15. Project work.―
10
(1) To allow the student to develop data collection and reporting skills in the area of
community, hospital and clinical pharmacy, a project work shall be carried out under
the supervision of a teacher. The project topic must be approved by the Head of the
Department or Head of the Institution. The same shall be announced to students
within one month of commencement of the fifth year classes. Project work shall be
presented in a written report and as a seminar at the end of the year. External and the
internal examiners shall do the assessment of the project work.
(2)Project work shall comprise of objectives of the work, methodology, results,
discussions and conclusions.
16. Objectives of project work.― The main objectives of the project work is to―
(i)Show the evidence of having made accurate description of published work of others
and of having recorded the findings in an impartial manner; and
(ii) Develop the students in data collection, analysis and reporting and interpretation
skills.
17. Methodology.― To complete the project work following methodology shall be

adopted, namely:―
(i)Students shall work in groups of not less than two and not more than four under an
authorised teacher;
(ii)Project topic shall be approved by the Head of the Department or Head of the
Institution;
(iii)Project work chosen shall be related to the pharmacy practice in community,
hospital and clinical setup. It shall be patient and treatment (Medicine) oriented, like
drug utilisation reviews, pharmacoepidemiology, pharmacovigilance or
pharmacoeconomics;
(iv)Project work shall be approved by the institutional ethics committee;
(v)student shall present at least three seminars, one in the beginning, one at middle
and one at the end of the project work; and
(vi)two-page write-up of the project indicating title, objectives, methodology
anticipated benefits and references shall be submitted to the Head of the Department
or Head of the Institution.
18. Reporting.―
11
(1) Student working on the project shall submit jointly to the Head of the Department
or Head of the Institution a project report of about 40-50 pages. Project report should
include a certificate issued by the authorised teacher, Head of the Department as well
as by the Head of the Institution
(2) Project report shall be computer typed in double space using Times Roman font on
A4 paper. The title shall be in bold with font size 18, sub-tiles in bold with font size
14 and the text with font size 12. The cover page of the project report shall contain
details about the name of the student and the name of the authorised teacher with font
size 14.
(3) Submission of the project report shall be done at least one month prior to the
commencement of annual or supplementary examination.
19. Evaluation.― The following methodology shall be adopted for evaluating the
project work―
(i)Project work shall be evaluated by internal and external examiners.
(ii) Students shall be evaluated in groups for four hours (i.e., about half an hour for a
group of four students).
(iii)Three seminars presented by students shall be evaluated for twenty marks each
and the average of best two shall be forwarded to the university with marks of other
subjects.
(iv)Evaluation shall be done on the following items: Marks
a) Write up of the seminar (7.5)
b) Presentation of work (7.5)
c) Communication skills (7.5)
d) Question and answer skills (7.5)
Total (30 marks)
(v)Final evaluation of project work shall be done on the following items: Marks
a) Write up of the seminar (17.5)
b) Presentation of work (17.5)
c) Communication skills (17.5)
d) Question and answer skills (17.5)
Total (70 marks)
Explanation.― For the purposes of differentiation in the evaluation in case of topic
being the same for the group of students, the same shall be done based on item
numbers b, c and d mentioned above.
12
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY ANANTAPUR

ANANTAPUR
Pharm.D-IV
APPENDIX A
INTERNSHIP
1. SPECIFIC OBJECTIVES :
i) to provide patient care in cooperation with patients, prescribers, and other

members of an interprofessional health care team based upon sound
therapeutic principles and evidence-based data, taking into account relevant
legal, ethical, social cultural, economic, and professional issues, emerging
technologies, and evolving biomedical, pharmaceutical, social or behavioral or
administrative, and clinical sciences that may impact therapeutic outcomes.
ii) to manage and use resources of the health care system, in cooperation with
patients, prescribers, other health care providers, and administrative and
supportive personnel, to promote health; to provide, assess, and coordinate
safe, accurate, and time-sensitive medication distribution; and to improve
therapeutic outcomes of medication use.
iii) to promote health improvement, wellness, and disease prevention in co-

operation with patients, communities, at-risk population, and other members
of an interprofessional team of health care providers.
iv) to demonstrate skills in monitoring of the National Health Programmes and

schemes, oriented to provide preventive and promotive health care services to
the community.
v) to develop leadership qualities to function effectively as a member of the

health care team organised to deliver the health and family welfare services in
existing socio-economic, political and cultural environment.
vi) to communicate effectively with patients and the community.
2. OTHER DETAILS :
i) All parts of the internship shall be done, as far as possible, in institutions in

India. In case of any difficulties, the matter may be referred to the Pharmacy
Council of India to be considered on merits.
ii) Where an intern is posted to district hospital for training, there shall be a
committee consisting of representatives of the college or university, and the
district hospital administration, who shall regulate the training of such trainee.
For such trainee a certificate of satisfactory completion of training shall be
obtained from the relevant administrative authorities which shall be
countersigned by the Principal or Dean of College.
iii) Every candidate shall be required, after passing the final Pharm.D. or
Pharm.D. (Post Baccalaureate) examination as the case may be to undergo
13
compulsory rotational internship to the satisfaction of the College authorities

and University concerned for a period of twelve months so as to be eligible for
the award of the degree of Pharm.D. or Pharm.D. (Post Baccalaureate) as the
case may be.
3. ASSESSMENT OF INTERNSHIP :
i) The intern shall maintain a record of work which is to be verified and certified
by the preceptor (teacher practioner) under whom he works. Apart from
scrutiny of the record of work, assessment and evaluation of training shall be
undertaken by an objective approach using situation tests in knowledge, skills
and attitude during and at the end of the training. Based on the record of work
and date of evaluation, the Dean or Principal shall issue certificate of
satisfactory completion of training, following which the university shall award
the degree or declare him eligible for it.
ii) Satisfactory completion of internship shall be determined on the basis of the

following:-
(1) Proficiency of knowledge required for each case management SCORE 0-

5
(2) The competency in skills expected for providing Clinical

Pharmacy Services SCORE 0-
5
(3) Responsibility, punctuality, work up of case, involvement

in patient care SCORE 0-
5
(4) Ability to work in a team (Behavior with other healthcare professionals

including medical doctors, nursing staff and colleagues). SCORE 0-
5
(5) Initiative, participation in discussions, research aptitude. SCORE 0-

5
Below Above
Poor Fair Average Excellent
Average Average
0 1 2 3 4 5
A Score of less than 3 in any of above items will represent unsatisfactory completion
of internship.
14
APPENDIX - B
20. Internship
Specific Objectives:
(i) To provide patient care in cooperation with patients, prescribers, and other
members of an interprofessional health care team based upon sound
therapeutic principles and evidence-based data, taking into account relevant
legal, ethical, social cultural, economic, and professional issues, emerging
technologies, and evolving biomedical, pharmaceutical, social or behavioral or
administrative, and clinical sciences that may impact therapeutic outcomes.
(ii) To manage and use resources of the health care system, in cooperation with
patients, prescribers, other health care providers, and administrative and
supportive personnel, to promote health; to provide, assess, and coordinate
safe, accurate, and time-sensitive medication distribution; and to improve
therapeutic outcomes of medication use.
(iii)To promote health improvement, wellness, and disease prevention in co-
operation with patients, communities, at-risk population, and other members
of an interprofessional team of health care providers.
(iv) To demonstrate skills in monitoring of the National Health Programmes and
schemes, oriented to provide preventive and promotive health care services to
the community.
(v) To develop leadership qualities to function effectively as a member of the
health care team organised to deliver the health and family welfare services in
existing socio-economic, political and cultural environment.
(vi) To communicate effectively with patients and the community.
Other details
1) All parts of the internship shall be done, as far as possible, in institutions in
India. In case of any difficulties, the matter may be referred to the Pharmacy
Council of India to be considered on merits.
2) Where an intern is posted to district hospital for training, there shall be a
committee consisting of representatives of the college or university, and the
district hospital administration, who shall regulate the training of such trainee.
For such trainee a certificate of satisfactory completion of training shall be
obtained from the relevant administrative authorities which shall be
countersigned by the Principal or Dean of College.
15
3) Every candidate shall be required, after passing the final Pharm.D. or

Pharm.D. (Post Baccalaureate) examination as the case may be to undergo
compulsory rotational internship to the satisfaction of the College authorities
and University concerned for a period of twelve months so as to be eligible for
the award of the degree of Pharm.D. or Pharm.D. (Post Baccalaureate) as the
case may be.
Assessment of Internship
(i) Each intern student shall have a minimum of 80% attendance in every month,
and a total of 80% at end for satisfactory completion of internship.
(ii) The intern shall maintain a record of work which is to be verified and certified
by the preceptor (teacher practitioner) under whom he works. Apart from
scrutiny of the record of work, assessment and evaluation of training shall be
undertaken by an objective approach using situation tests in knowledge, skills
and attitude during and at the end of the training. Based on the record of work
and date of evaluation, the Dean or Principal shall issue certificate of
satisfactory completion of training, following which the university shall award
the degree or declare him eligible for it.
(iii)Satisfactory completion of internship shall be determined on the basis of the
following:
1. Proficiency of knowledge required for each case management SCORE 0-5
2. The competency in skills expected for providing Clinical Pharmacy Services
SCORE 0-5
3. Responsibility, punctuality, work up of case, involvement in patient care
SCORE 0-5
4. Ability to work in a team (Behaviour with other healthcare professionals
including medical doctors, nursing staff and colleagues). SCORE 0-5
5. Initiative, participation in discussions, research aptitude. SCORE 0-5
Poor Fair Below Average Above Excellent
Average Average
0 1 2 3 4 5
A Score of less than 3 in any of above items will represent unsatisfactory completion
of internship.
16
21. Transitory regulations:

Candidates who have been detained for want of attendance or not fulfilled academic
requirements or who have failed after having undergone the course in earlier
regulations or have discontinued and wish to continue the course are eligible for
admission into the unfinished semester from the date of commencement of class work
with the same or equivalent subjects as and when subjects are offered, subject to
Section 2. and continue to be in the academic regulations they were first admitted.
22. With – holding of results:

If the candidate has not paid dues to the university or if any case of in-discipline or
malpractice is pending against him, the result of the candidate shall be withheld and
he will not be allowed/ promoted into the next higher semester. The issue of degree is
liable to be withheld in such cases.
23. General:
i. The academic regulations should be read as a whole for purpose of any
interpretation.
ii. Disciplinary action for Malpractice / improper conductin examinations is
appended
iii. Where the words “he”, “him”, “his”, occur in the regulations, they include
“she”, “her”, “hers”.
iv. In the case of any doubt or ambiguity in the interpretation of the above rules,
the decision of the Vice-Chancellor is final.
v. The University may change or amend the academic regulations or syllabi at
any time and the changes or amendments shall be made applicable to all the
students on roles with effect from the dates notified by the University.
17
24. RULES FOR DISCIPLINARY ACTION FOR MALPRACTICE / IMPROPER

CONDUCT IN EXAMINATIONS
Nature of Malpractices/Improper conduct Punishment
If the candidate:
1. (a) Possesses or keeps accessible in examination Expulsion from the examination hall and
hall, any paper, note book, programmable cancellation of the performance in that
calculators, Cell phones, pager, palm subject only.
computers or any other form of material
concerned with or related to the subject of
the examination (theory or practical) in which
he is appearing but has not made use of
(material shall include any marks on the body
of the candidate which can be used as an aid
in the subject of the examination)
(b) Gives assistance or guidance or receives it Expulsion from the examination hall and
from any other candidate orally or by any cancellation of the performance in that
other body language methods or subject only of all the candidates involved.
communicates through cell phones with any In case of an outsider, he will be handed
candidate or persons in or outside the exam over to the police and a case is registered
hall in respect of any matter. against him.
2. Has copied in the examination hall from any Expulsion from the examination hall and
paper, book, programmable calculators, palm cancellation of the performance in that
computers or any other form of material subject and all other subjects the candidate
relevant to the subject of the examination has already appeared including practical
(theory or practical) in which the candidate is examinations and project work and shall not
appearing. be permitted to appear for the remaining
examinations of the subjects of that
Semester/year.
The Hall Ticket of the candidate is to be
cancelled and sent to the University.
3. Impersonates any other candidate in The candidate who has impersonated shall
connection with the examination. be expelled from examination hall. The
candidate is also debarred and forfeits the
seat. The performance of the original
candidate who has been impersonated, shall
be cancelled in all the subjects of the
examination (including practicals and project
work) already appeared and shall not be
allowed to appear for examinations of the
remaining subjects of that semester/year.
The candidate is also debarred for two
consecutive semesters from class work and
all University examinations. The
continuation of the course by the candidate
is subject to the academic regulations in
connection with forfeiture of seat. If the
imposter is an outsider, he will be handed
over to the police and a case is registered
against him.
4. Smuggles in the Answer book or additional Expulsion from the examination hall and
sheet or takes out or arranges to send out the cancellation of performance in that subject
question paper during the examination or and all the other subjects the candidate has
answer book or additional sheet, during or already appeared including practical
after the examination. examinations and project work and shall not
be permitted for the remaining examinations
of the subjects of that semester/year. The
candidate is also debarred for two
18

all University examinations. The continuation
of the course by the candidate is subject to
the academic regulations in connection with
forfeiture of seat.
5. Uses objectionable, abusive or offensive Cancellation of the performance in that
language in the answer paper or in letters to subject.
the examiners or writes to the examiner
requesting him to award pass marks.
6. Refuses to obey the orders of the Chief In case of students of the college, they shall
Superintendent/Assistant – Superintendent / be expelled from examination halls and
any officer on duty or misbehaves or creates cancellation of their performance in that
disturbance of any kind in and around the subject and all other subjects the
examination hall or organizes a walk out or candidate(s) has (have) already appeared
instigates others to walk out, or threatens the and shall not be permitted to appear for the
officer-in charge or any person on duty in or remaining examinations of the subjects of
outside the examination hall of any injury to that semester/year. The candidates also are
his person or to any of his relations whether debarred and forfeit their seats. In case of
by words, either spoken or written or by signs outsiders, they will be handed over to the
or by visible representation, assaults the police and a police case is registered against
officer-in-charge, or any person on duty in or them.
outside the examination hall or any of his
relations, or indulges in any other act of
misconduct or mischief which result in
damage to or destruction of property in the
examination hall or any part of the College
campus or engages in any other act which in
the opinion of the officer on duty amounts to
use of unfair means or misconduct or has the
tendency to disrupt the orderly conduct of
the examination.
7. Leaves the exam hall taking away answer Expulsion from the examination hall and
script or intentionally tears of the script or cancellation of performance in that subject
any part thereof inside or outside the and all the other subjects the candidate has
examination hall. already appeared including practical
examinations and project work and shall not
candidate is also debarred for two
all University examinations. The continuation
of the course by the candidate is subject to
the academic regulations in connection with
forfeiture of seat.
8. Possess any lethal weapon or firearm in the Expulsion from the examination hall and
examination hall. cancellation of the performance in that
subject and all other subjects the candidate
has already appeared including practical
candidate is also debarred and forfeits the
seat.
9. If student of the college, who is not a Student of the colleges expulsion from the
candidate for the particular examination or examination hall and cancellation of the
any person not connected with the college performance in that subject and all other
indulges in any malpractice or improper subjects the candidate has already appeared
conduct mentioned in clause 6 to 8. including practical examinations and project
work and shall not be permitted for the
19
remaining examinations of the subjects of

that semester/year. The candidate is also
debarred and forfeits the seat.
Person(s) who do not belong to the
College will be handed over to police and, a
police case will be registered against them.
10. Comes in a drunken condition to the Expulsion from the examination hall and
examination hall. cancellation of the performance in that
subject and all other subjects the candidate
has already appeared including practical
of the subjects of that semester/year.
11. Copying detected on the basis of internal Cancellation of the performance in that
evidence, such as, during valuation or during subject and all other subjects the candidate
special scrutiny. has appeared including practical
examinations and project work of that
semester/year examinations.
12. If any malpractice is detected which is not
covered in the above clauses 1 to 11 shall be
reported to the University for further action
to award suitable punishment.
25. Malpractices identified by squad or special invigilators

1. Punishments to the candidates as per the above guidelines.
2. Punishment for institutions : (if the squad reports that the college is also involved
in encouraging malpractices)
(i) A show cause notice shall be issued to the college.
(ii) Impose a suitable fine on the college.
(iii)Shifting the examination centre from the college to another college for a
specific period of not less than one year.
20

Pharm. D - I YEAR
(17T00101) HUMAN ANATOMY & PHYSIOLOGY (THEORY)
Theory:3 Hrs. /Week
1. Scope and Objectives: This course is designed to impart a fundamental knowledge on

the structure and functions of the human body. It also helps in understanding both
homeostasis mechanisms and homeostatic imbalances of various body systems. Since a
medicament, which is produced by pharmacist, is used to correct the deviations in human
body, it enhances the understanding of how the drugs act on the various body systems in
correcting the disease state of the organs.
2. Upon completion of the course the student shall be able to:

a. describe the structure (gross and histology) and functions of various organs of the
human body;
b. describe the various homeostatic mechanisms and the ir imbalances of various
systems;
c. identify the various tissues and organs of the different systems of the human body;
d. perform the hematological tests and also record blood pressure, heart rate, pulse and
Respiratory volumes;
e. appreciate coordinated working pattern of different organs of each system; and
f. appreciate the interlinked mechanisms in the maintenance of normal functioning
(homeostasis) of human body
3. Course materials:
Text books
a. Tortora Gerard J. and Nicholas, P. Principles of anatomy and physiology Publisher
Harpercollins college New York.
b. Wilson, K.J.W. Ross and Wilson’s foundations of anatomy and physiology.
Publisher: Churchill Livingstone, Edinburg.
Reference books
a. Guytonarthur, C. Physiology of human body. Publisher: Holtsaunders.

b. Chatterjee,C.C. Human physiology. Volume 1&11. Publisher: medical allied agency,
Calcutta.
c. Peter L. Williams, Roger Warwick, Mary Dyson and Lawrence, H.
d. Gray’s anatomy. Publisher: Churchill Livingstone, London.
4. Lecture wise program :

Topics
1 i) Scope of anatomy and physiology, basic terminologies used in this subject

(Description of the body as such planes and terminologies)
ii) Structure of cell – its components and their functions.
Elementary tissues of the human body: epithelial, connective, Muscular and nervous
tissues-their sub-types and characteristics
i) Osseous system - structure, composition and functions of theSkeleton. (done in
practical classes - 6hrs)
iii) Classification of joints, Types of movements of joints and disorders of joints

(Definitions only)
2 i)Haemopoetic System
a)Composition and functions of blood
b)Haemopoesis and disorders of blood components (definition of d isorder)
21
c)Blood groups
d)Clotting factors and mechanism
e)Platelets and disorders of coagulation
ii) Lymph
a)Lymph and lymphatic system, composition, formation and circulation.
b)Spleen: structure and functions, Disorders
c)Disorders of lymphatic system (definition only)
iii) Cardiovascular system

a)Anatomy and functions of heart
b)Blood vessels and circulation (Pulmonary, coronary and systemic circulation)
c)Electrocardiogram (ECG)
d)Cardiac cycle and heart sounds
e)Blood pressure – its maintenance and regulation
f)Definition of the following disorders
Hypertension, Hypotension, Arteriosclerosis, Atherosclerosis, Angina, Myocardial
infarction, Congestive heart failure, Cardiac arrhythmias
3 i) Respiratory system
a)Anatomy of respiratory organs and functions
b)Mechanism / physiology of respiration and regulation of respiration
c)Transport of respiratory gases
d)Respiratory volumes and capacities, and Definition of: Hypoxia, Asphyxia,
Dybarism, Oxygen therapy and resuscitation.
ii) Digestive system

a)Anatomy and physiology of GIT
b) Anatomy and functions of accessory glands of GIT
c)Digestion and absorption
d)Disorders of GIT (definitions only)
iii) Nervous system

a)Definition and classification of nervous system
b)Anatomy, physiology and functional areas of cerebrum
c)Anatomy and physiology of cerebellum
d)Anatomy and physiology of mid brain
e)Thalamus, hypothalamus and Basal Ganglia
f)Spinal card: Structure & reflexes – mono-poly-planter
g)Cranial nerves – names and functions
h)ANS – Anatomy & functions of sympathetic & parasympathetic N.S.
4 i) Urinary system
a)Anatomy and physiology of urinary system
b)Formation of urine
c) Renin Angiotensin system – Juxtaglomerular apparatus - acid base Balance
d) Clearance tests and micturition
ii) Endocrine system

a)Pituitary gland
b)Adrenal gland
c)Thyroid and Parathyroid glands
d)Pancreas and gonads
iii) Reproductive system

a)Male and female reproductive system
b)Their hormones – Physiology of menstruation
c)Spermatogenesis & Oogenesis
22
d)Sex determination (genetic basis)

e)Pregnancy and maintenance and parturition
f)Contraceptive devices
5 i)Sense organs
a)Eye
b)Ear
c)Skin
d)Tongue & Nose
ii) Skeletal muscles

a)Histology
b)Physiology of Muscle contraction
c)Physiological properties of skeletal muscle and their disorders (definitions)
iii) Sports physiology

a)Muscles in exercise, Effect of athletic training on muscles and muscle performance,
b)Respiration in exercise, CVS in exercise, Body heat in exercise, Body fluids and
salts in exercise,
c)Drugsandathletics
23

Pharm. D - I YEAR
(17T00107) HUMAN ANATOMY & PHYSIOLOGY (PRACTICAL)
Practical : 3 Hrs./Week
General Requirements: Dissection box, Laboratory Napkin, muslin cloth, record, Observation
book(100pages), Stationary items, Blood lancet.
Course materials:
Text books
Goyal, R. K, Natvar M.P, and Shah S.A, Practical anatomy, physiology and biochemistry, latest
edition, Publisher: B.S Shah Prakashan, Ahmedabad.
Reference books
Ranade VG, Text book of practical physiology, Latest edition, Publisher: PVG, Pune Anderson
Experimental Physiology, Latest edition, Publisher: NA
List of Experiments:
1. Study of tissues of human body
(a) Epithelial tissue.
(b) Muscular tissue.
2. Study of tissues of human body

(a) Connective tissue.
(b) Nervous tissue.
3. Study of appliances used in hematological experiments.
4. Determination of W.B.C. count of blood.
5. Determination of R.B.C. count of blood.
6. Determination of differential count of blood.
7. Determination of
(a) Erythrocyte Sedimentation Rate.
(b) Hemoglobin content of Blood.
(c) Bleeding time & Clotting time.
8. Determination of
(a) Blood Pressure.
(b) Blood group.
9. Study of various systems with the help of charts, models & specimens
(a) Skeleton system part I-axial skeleton.
(b)Skeleton system part II- appendicular skeleton.
(c)Cardiovascular system.
(d)Respiratory system.
(e)Digestive system.
(f)Urinary system.
(g)Nervous system.
(h)Special senses.
(i) Reproductive system.
24
10. Study of different family planning appliances.

11. To perform pregnancy diagnosis test.
12. Study of appliances used in experimental physiology.
13. To record simple muscle curve using gastroenemius sciatic nerve preparation.
14. To record simple summation curve using gastroenemius sciatic nerve preparation.
15. To record simple effect of temperature using gastroenemius sciatic nerve preparation.
16. To record simple effect of load & after load using gastroenemius sciatic nerve preparation.
17. To record simple fatigue curve using gastroenemius sciatic nerve preparation.
Scheme of Practical Examination:
Sessionals Annual
Identification 04 10
Synopsis 04 10
Major Experiment 07 20
Minor Experiment 03 15
Viva 02 15
Max Marks 20 70
Duration 03hrs 04hrs
Note : Total sessional marks is 30 (20 for practical sessional plus 10 marks for regularity,
promptness, viva-voce and record maintenance).
25

Pharm. D - I YEAR
(17T00102) PHARMACEUTICS (THEORY)

Theory: 2 Hrs. /Week
1. Scope and objectives: This course is designed to impart a fundamental knowledge on the art and
science of formulating different dosage forms. It prepares the students for most basics of the
applied field of pharmacy.
2. Upon the completion of the course the student s hould be able to:
a. know the formulation aspects of different dosage forms;
b.do different pharmaceutical caluculation involved in formulation;
c.formulate different types of dosage forms; and
d.appreciate the importance of good formulation for effectiveness.
Text books
a. Cooper and Gunns Dispensing for pharmacy students.
b.A text book Professional Pharmacy by N.K.Jain and S.N.Sharma.
Reference books
a. Introduction to Pharmaceutical dosage forms by Howard C. Ansel.
b. Remington’s Pharmaceutical Sciences.
c. Register of General Pharmacy by Cooper and Gunn.
d. General Pharmacy by M.L.Schroff.
4. Lecture wise programme:

Topics
1. a. Introduction to dosage forms - classification and definitions

b.Prescription: definition, parts and handling
c.Posology: Definition, Factors affecting dose selection. Calculation of childrenand infant
doses.
d. Historical back ground and development of profession of pharmacy and pharmaceutical
industry in brief.
2. i) Development of Indian Pharmacopoeia and introduction to o ther Pharmacopoeias such as
BP, USP, European Pharmacopoeia, Extra pharmacopoeia and Indian national formulary.
ii) Weights and measures, Calculations involving percentage solutions, allegation, proof spirit,
isotonic solutions etc.
3. i) Powders and Granules: Classification advantages and disadvantages, Preparation of simple,
compound powders, Insufflations, Dusting powders, Eutectic and Explosive powders, Tooth
powder and effervescent powders and granules.
ii) Monophasic Dosage forms: Theoretical aspects of formulation including adjuvant like
stabilizers, colorants, flavours with examples. Study of Monophasic liquids like gargles,mouth
washes, Throat paint, Ear drops, Nasal drops, Liniments and lotions, Enemas and collodions.
4. A) Biphasic dosage forms: Suspensions and emulsions, Definition, advantages and
disadvantages, classification, test for the type of emulsion, formulation, stability and
evaluation.
B) Suppositories and pessaries: Definition, advantages and disadvantages, types of base,
method of preparation, Displacement value and evaluation.
26
C)Galenicals: Definition, equipment for different extraction processes like infusion,

Decoction, Maceration and Percolation, methods of preparation of spirits, tinctures and
extracts.
5. i) Pharmaceutical calculations.
ii) Surgical aids: Surgical dressings, absorbable gelatin sponge, sutures, ligatures and
medicated bandages.
iii) Incompatibilities: Introduction, classification and methods to overcome the
incompatibilities.
27

Pharm. D - I YEAR
(17T00108) PHARMACEUTICS (PRACTICAL)
Practical : 3 Hrs. /Week
1. Syrups
a. Simple Syrup I.P
b.Syrup of Ephedrine Hcl NF
c.Syrup Vasaka IP
d.Syrup of ferrous Phosphate IP
e.Orange Syrup
2. Elixir
a. Piperizine citrate elixir BP
b.Cascara elixir BPC
c.Paracetamol elixir BPC
3. Linctus
a.Simple Linctus BPC
b.Pediatric simple Linctus BPC
4. Solutions
a.Solution of cresol with soap IP
b.Strong solution of ferric chloride BPC
c.Aqueous Iodine Solution IP
d.Strong solution of Iodine IP
e.Strong solution of ammonium acetate IP
5. Liniments
a. Liniment of turpentine IP*
b.Liniment of camphor IP
6. Suspensions*
a.Calamine lotion
b.Magnesium Hydroxide mixture BP
7. Emulsions*
a.Cod liver oil emulsion
b.Liquid paraffin emulsion
8. Powders*
a.Eutectic powder
b.Explosive powder
c.Dusting powder
d.Insufflations
9. Suppositories*
a.Boric acid suppositories
b.Chloral suppositories
10. Incompatibilities
28
a.Mixtures with Physical

b.Chemical & Therapeutic incompatibilities
*Colourless bottles required for dispensing  Paper envelope (white), butter paper and white paper
required for dispensing.
Sessionals Annual
Synopsis 05 15
Viva 02 15
Max Marks 20 70
Note : Total sessional marks is 30 (20 for practical sessional plus 10 marks for regularity, promptness,
viva-voce and record maintenance).
29

Pharm. D - I YEAR
(17T00103) MEDICINAL BIOCHEMISTRY (THEORY)
1. Scope of the Subject: Applied biochemistry deals with complete understanding of the molecular
level of the chemical process associated with living cells.Clinical chemistry deals with the study
of chemical aspects of human life in health and illness and the application of chemical laboratory
methods to diagnosis, control of treatment, and prevention of diseases
2. Objectives of the Subject (Know, do, appreciate) :

The objective of the present course is providing biochemical facts and the principles to the
students of pharmacy. Upon completion of the subject student shall be able to –
a. understand the catalytic activity of enzymes and importance of isoenzymes in diagnosis of
diseases;
b. know the metabolic process of biomolecules in health and illness (metabolic disorders);
c. understand the genetic organization of mammalian genome; protein synthesis; replication;
mutation and repair mechanism;
d. know the biochemical principles of organ function tests of kidney, liver and endocrine gland;
and
e. do the qualitative analysis and determination of biomolecules in the body fluids.
Text books (Theory)

a. Harpers review of biochemistry - Martin
b.Text book of biochemistry – D.Satyanarayana
c.Text book of clinical chemistry- Alex kaplan&LaverveL.Szabo
Reference books (Theory)

a.Principles of biochemistry -- Lehninger
b.Text book of biochemistry -- Ramarao
c.Practical Biochemistry-David T.Plummer.
d.Practical Biochemistry-Pattabhiraman.

Topics
1. a. Introduction to biochemistry: Cell and its biochemical organization, transport process
across the cell membranes. Energy rich compounds; ATP, Cyclic AMP and their biological
significance.
b. Enzymes: Definition; Nomenclature; IUB classification; Factor affecting enzyme activity;
Enzyme action; enzyme inhibition. Isoenzymes and their therapeutic anddiagnostic
applications; Coenzymes and their biochemical role and deficiency diseases.
2. i) Carbohydrate metabolism: Glycolysis, Citric acid cycle (TCA cycle), HMP shunt,
Glycogenolysis, gluconeogenesis, glycogenesis. Metabolic disorders ofcarbohydrate
metabolism (diabetes mellitus and glycogen storage diseases); Glucose, Galactose tolerance
test and their significance; hormonal regulation of carbohydrate metabolism.
ii)Lipid metabolism: Oxidation of saturated (β-oxidation); Ketogenesis andketolysis;
biosynthesis of fatty acids, lipids; metabolism of cholesterol; Hormonal regulation of lipid
30
metabolism. Defective metabolism of lipids (Atheroslerosis, fatty liver,

hypercholesterolmiea).
3. i) Biological oxidation: Coenzyme system involved in Biological oxidation. Electron
transport chain (its mechanism in energy capture; regulation and inhibition); Uncouplers of
ETC; Oxidative phosphorylation;
iii) Protein and amino acid metabolism: protein turn over; nitrogen balance; Catabolism of
Amino acids (Transamination, deamination & decarboxylation).Urea cycle and its metabolic
disorders; production of bile pigments; hyperbilirubinemia, porphoria, jaundice. Metabolic
disorder of Amino acids.
iv) Nucleic acid metabolism: Metabolism of purine and pyrimidine nucleotides; Protein
synthesis; Genetic code; inhibition of protein synthesis; mutation and repair mechanism; DNA
replication (semiconservative /onion peel models) and DNA repair mechanism.
4. Introduction to clinical chemistry: Cell; composition; malfunction; Roll of the clinical
chemistry laboratory.
The kidney function tests: Role of kidney; Laboratory tests for normal function includes-
a) Urine analysis (macroscopic and physical examination, quantitative and semiquantitative
tests.)
b) Test for NPN constituents. (Creatinine /urea clearance, determination of blood and urine
creatinine, urea and uric acid)
c)Urine concentration test
d)Urinary tract calculi. (stones)
Liver function tests: Physiological role of liver, metabolic, storage, excretory, protective,
circulatory functions and function in blood coagulation.
a) Test for hepatic dysfunction-Bile pigments metabolism.
b)Test for hepatic function test- Serum bilirubin, urine bilirubin, and urine urobilinogen.
c)Dye tests of excretory function.
d)Tests based upon abnormalities of serum proteins.
Selected enzyme tests.
5. i) Lipid profile tests: Lipoproteins, composition, functions. Determination of serum lipids,

total cholesterol, HDL cholesterol, LDL cholesterol and triglycerides.
ii)Immunochemical techniques for determination of hormone levels and protein levels in

serum for endocrine diseases and infectious diseases.
Radio immuno assay (RIA) and Enzyme Linked Immuno Sorbent Assay (ELISA)
iii) Electrolytes: Body water, compartments, water balance, and electrolytedistrubution.
Determination of sodium, calcium potassium, chlorides, bicarbonates in the body fluids.
31

Pharm. D - I YEAR
(17T00109) MEDICINAL BIOCHEMISTRY (PRACTICAL)

practical: 3 Hrs. /Week
Title of the Experiment:
1. Qualitative analysis of normal constituents of urine.*
2. Qualitative analysis of abnormal constituents of urine.*
3. Quantitative estimation of urine sugar by Benedict’s reagent method.**
4. Quantitative estimation of urine chlorides by Volhard's method.**
5. Quantitative estimation of urine creatinine by Jaffe’s method.**
6. Quantitative estimation of urine calcium by precipitation method.**
7. Quantitative estimation of serum cholesterol by LibermannBurchard’s method.**
8. Preparation of Folin Wu filtrate from blood.*
9. Quantitative estimation of blood creatinine.**
10. Quantitative estimation of blood sugar Folin- Wu tube method.**
11. Estimation of SGOT in serum.**
12. Estimation of SGPT in serum.**
13. Estimation of Urea in Serum.**
14. Estimation of Proteins in Serum.**
15. Determination of serum bilirubin**
16. Determination of Glucose by means of Glucoseoxidase.**
17. Enzymatic hydrolysis of Glycogen/Starch by Amylases.**
18. Study of factors affecting Enzyme activity. (pH& Temp.)**
19. Preparation of standard buffer solutions and its pH measurements (any two)*
20. Experiment on lipid profile tests**
21. Determination of sodium,calcium and potassium in serum.**
** indicate major experiments & * indicate minor experiments
Assignments:
Format of the assignment
1. Minimum & Maximum number of pages.
2. It shall be computer draft copy.
3. Reference(s) shall be included at the end.
4. Name and signature of the student.
5. Assignment can be a combined presentation at the end of the academic year.
6. Time allocated for presentation may be 8+2 Min.
Sessionals Annual
Synopsis 05 15
Viva 02 15
Max Marks 20 70
32

Pharm. D - I YEAR
(17T00104) PHARMACEUTICAL ORGANIC CHEMISTRY (THEORY)
1. Scope and objectives: This course is designed to impart a very good knowledge about
a. IUPAC/Common system of nomenclature of simple organic compounds
belonging to different classes of organic compounds;
b.Some important physical properties of organic compounds;
c. Free radical/ nucleophyllic [alkyl/ acyl/ aryl] /electrophyllic substitution, free radical/
nucleophyllic / electrophyllic addition, elimination, oxidation andreduction reactions
with mechanism, orientation of the reaction, order of reactivity, stability of compounds;
d. Some named organic reactions with mechanisms; and
e. Methods of preparation, test for purity, principle involved in the assay, important
medicinal uses of some important organic compounds.
Text books
a. T.R.Morrison and R. Boyd - Organic chemistry,
b. Bentley and Driver-Text book of Pharmaceutical chemistry
c. I.L.Finer- Organic chemistry, the fundamentals of chemistry
Reference books
a. Organic chemistry – J.M.Cram and D.J.Cram
b. Organic chemistry- Brown
c. Advanced organic chemistry- Jerry March, Wiley
d. Organic chemistry- Cram and Hammered, Pine Hendrickson
3. Lecture wise programme :

Topics
1. i) Structures and Physical properties:
a.Polarity of bonds, polarity of molecules, M.P, Inter molecular forces, B.P,Solubility,
non ionic solutes and ionic solutes, protic and aprotic Solvents, ion pairs,
b.Acids and bases, Lowry bronsted and Lewis theories
c.Isomerism
ii) Nomenclature of organic compound belonging to the following classes
Alkanes,Alkenes, Dienes, Alkynes, Alcohols, Aldehydes, Ketones, Amides, Amines,
Phenols, Alkyl Halides, Carboxylic Acid, Esters, Acid Chlorides And Cycloalkanes.
iii)Free radicals chain reactions of alkane : Mechanism, relative reactivity and stability
iv) Alicyclic compounds : Preparations of cyclo alkanes, Bayer strain theory and orbital
picture of angle strain.
2. i) Nuclophilic aliphatic substitution mechanism: Nucleophiles and leaving groups,
kinetics of second and first order reaction, mechanism and kinetics of SN 2 reactions.
Stereochemistry and steric hindrance, role of solvents, phase transfer catalysis,
mechanism and kinetics of SN1 reactions, stereochemistry, carbocation
and their stability, rearrangement of carbocation, role of solvents in SN1 reaction, Ion
dipole bonds, SN2 versus SN1 solvolyses, nucleophilic assistance by the solvents.
33
ii) Dehydro halogenation of alkyl halides: 1,2 elimination, kinetics, E2 and E1

mechanism, elimination via carbocation, evidence for E2 mechanism, absence of
rearrangement isotope effect, absence hydrogen exchange, the element effect,orientation
and reactivity, E2 versus E1, elimination versus substitution, dehydration of alcohol, ease
of dehydration, acid catalysis, reversibility, orientation.
iii) Electrophillic and free radicals addition: Reactions at carbon-carbon, double bond,
electrophile, hydrogenation, heat of hydrogenation and stability of alkenes,markownikoff
rule, addition of hydrogen halides, addition of hydrogen bromides, peroxide effect,
electrophillic addition, mechanism, rearrangement, absence ofhydrogen exchange,
orientation and reactivity, addition of halogen, mechanism, halohydin formation,
mechanism of free radicals additon, mechanism of peroxide initiated addition of
hydrogen bromide, orientation of free addition, additions of carbene to alkene, cyclo
addition reactions.
iv) Carbon-carbon double bond as substituents: Free radical halogenations
ofalkenes, comparision of free radical substitution with free radical addition, free radical
substitution in alkenes, orientation and reactivity, allylic rearrangements.
3. i) Theory of resonance: Allyl radical as a resonance hybrid, stability, orbital picture,
resonance stabilisation of allyl radicals, hyper conjugation, allylcation asa resonance
hybrid, nucleophyllic substitution in allylic substrate, SN1 reactivity, allylic
rearrangement, resonance stabilisation of allylcation, hyper conjugation,nucleophilic
substitution in allylic substrate, SN2 nucleophilic substituion in vinylic substrate,
vinyliccation, stability of conjugated dienes, resonance in alkenes, hyper conjugation,
ease of formation of conjugated dienes, orientation ofelimination, electrophilic addition
to conjugated dienes, 1,4- addition, 1,2-versus 1,4-addition, rate versus equilibrium,
orientation and reactivity of free radical addition to conjugated dienes.
ii) Elecrophilic aromatic substitution: Effect of substituent groups, determination of
orientation, determination of relative reactivity, classification of substituentgroup,
mechanism of nitration, sulphonation, halogenation, friedel craft alkylation, friedel craft
acylation, reactivity and orientation, activating anddeactivating O,P,M directing groups,
electron release via resonance, effect of halogen on electrophilic aromatic substitution in
alkyl benzene, side chain halogination of alkyl benzene, resonance stabilization of benzyl
radical.
4. i) Nucleophilic addition reaction: Mechanism, ionisation of carboxylic acids, acidity
constants, acidity of acids, structure of carboxylate ions, effect of substituent on acidity,
nucleophilic acyl substitution reaction, conversion of acidto acid chloride, esters, amide
and anhydride. Role of caboxyl group, comparison of alkyl nucleophilic substitution with
acyl nucleophilic substitution.
ii) Mechanism of aldol condensation, claisen condensation, cannizzaro reaction,crossed
aldol condensation, crossed cannizzaro reaction, benzoin condensation, perkin
condensation. Knoevenagel, Reformatsky reaction, Wittig reaction, Michael addition.
iii) Hoffman rearrangement: Migration to electron deficient nitrogen, Sandmeyer’s
reaction, basicity of amines, diazotisation and coupling, acidity of phenols, Williamson
synthesis, Fries rearrangement, Kolbe reaction, Reimer tieman’s reactions.
5. i) Nucleophilic aromatic substitution: Bimolecular displacement
mechanisms,orientation, comparison of aliphatic nucleophilic substitution with that of
aromatic.
ii) Oxidation reduction reaction.
iii) Study of the following official compounds- preparation, test for purity, assay and
medicinal uses of Chlorbutol, Dimercaprol, Glyceryltrinitrate, Urea, Ethylene
34
diamine dihyrate, Vanillin, Paraldehyde, Ethylene chloride, Lactic acid, Tartaric acid,
citric acid, salicylic acid, aspirin, methyl salicylate, ethyl benzoate, benzylbenzoate,
dimethyl pthalate, sodium lauryl sulphate, saccharin sodium, mephensin.
35

Pharm. D - I YEAR
(17T00110) PHARMACEUTICAL ORGANIC CHEMISTRY (PRACTICAL)

I. Introduction to the various laboratory techniques through de monstration involving

synthesis of the following compounds (at least 8 compounds to be synthesised):
1. Acetanilde / aspirin (Acetylation)
2.Benzanilide / Phenyl benzoate (Benzoylation)
3.P-bromo acetanilide / 2,4,6 – tribromo aniline (Bromination)
4.Dibenzylidene acetone (Condensation)
5.1-Phenylazo-2-napthol (Diazotisation and coupling)
6.Benzoic acid / salicylic acid (Hydrolysis of ester)
7.M-dinitro benzene (Nitration)
8.9, 10 – Antharaquinone (Oxidation of anthracene) / preparation of benzoic acid from
toluene or benzaldehyde
9. M-phenylene diamine (Reduction of M-dinitrobenzene) / Aniline from nitrobenzene
10.Benzophenoneoxime
11.Nitration of salicylic acid
12.Preparation of picric acid
13.Preparation of O-chlorobenzoic acid from O-chlorotolune
14.Preparation of cyclohexanone from cyclohexanol
II. Identification of organic compounds belonging to the following classes by :

Systematic qualitative organic analysis including preparation of derivatives Phenols,
amides, carbohydrates, amines, carboxylic acids, aldehyde and ketones, Alcohols, esters,
hydrocarbons, anilides, nitrocompounds.
III. Introduction to the use of stereo models:

Methane, Ethane, Ethylene, Acetylene, Cis alkene, Trans alkene, inversion of
configuration.

Sessionals Annual
Synopsis 05 15
Viva 02 15
Max Marks 20 70
36

Pharm. D - I YEAR
(17T00105) PHARMACEUTICAL INORGANIC CHEMISTRY (THEORY)

1. Scope and objectives: This course mainly deals with fundamentals of Analytical chemistry and
also the study of inorganic pharmaceuticals regarding their monographs and also the course
deals with basic knowledge of analysis of various pharmaceuticals.
2. Upon completion of the course student shall be able to:

a. understand the principles and procedures of analysis of drugs and also regarding the
application of inorganic pharmaceuticals;
b. know the analysis of the inorganic pharmaceuticals their applications; and
c.appreciate the importance of inorganic pharmaceuticals in preventing and curing the disease.
Text books
a. A text book Inorganic medicinal chemistry by Surendra N. Pandeya
b.A. H. Beckett and J. B. Stanlake’s Practical Pharmaceutical chemistry Vol-I &Vol-II
c. Inorganic Pharmaceutical Chemistry III-Edition P.Gundu Rao
Reference books
a.Inorganic Pharmaceutical Chemistry by Anand&Chetwal
b.Pharmaceutical Inorganic chemistry by Dr.B.G.Nagavi
c.Analytical chemistry principles by John H. Kennedy d. I.P.1985 and 1996, Govt. of India,
Ministry of health

Topics
1. A. Errors
B. Volumetric analysis
C. Acid-base titrations
D. Redox titrations
2. A. Non aqueous titrations
B. Precipitation titrations
C. Complexometric titrations
D. Theory of indicators
3. A. Gravimetry
B. Limit tests
C. Medicinal gases
D. Acidifiers
4. A. Antacids
B. Cathartics
C. Electrolyte replenishers
D. Essential Trace elements
5. A. Antimicrobials
B. Pharmaceutical aids
C. Dental Products
D .Miscellaneous compounds
E. Radio Pharmaceuticals
37

Pharm. D - I YEAR
(17T00111) PHARMACEUTICAL INORGANIC CHEMISTRY (PRACTICAL)

1. Limit test (6 exercises)

a. Limit test for chlorides
b. Limit test for sulphates
c. Limit test for iron
d. Limit test for heavy metals
e. Limit test for arsenic
f. Modified limit tests for chlorides and sulphates
2. Assays (10 exercises)

a. Ammonium chloride- Acid-base titration
b.Ferrous sulphate- Cerimetry
c.Coppersulpahte- Iodometry
d.Calcilugluconate- Complexometry
e.Hydrogen peroxide – Permanganometry
f.Sodium benzoate – Nonaqueous titration
g.Sodium chloride – Modified volhard’s method
h.Assay of KI – KIO3 titration
i.Gravimetric estimation of barium as barium sulphate
j.Sodium antimony gluconate or antimony potassium tartarate
3. Estimation of mixture (Any two exercises)

a. Sodium hydroxide and sodium carbonate
b. Boric acid and Borax
c. Oxalic acid and sodium oxalate
4. Test for identity (Any three exercises)

a. Sodium bicorbonate
b. Barium sulphate
c. Ferrous sulphate
d. Potassium chloride
5. Test for purity (Any two exercises)

a. Swelling power in Bentonite
b. Acid neutralising capacity in aluminium hydroxide gel
c. Ammonium salts in potash alum
d. Adsorption power heavy Kaolin
e. Presence of Iodates in KI
6. Preparations (Any two exercises)

a. Boric acids
b. Potash alum
c. Calcium lactate
38
d. Magnesium suphate
Scheme of Practical Examination :

Sessionals Annual
Synopsis 05 15
Minor Experiment1&2 03 15
Viva 02 15
Max Marks 20 70
Note : Total sessional marks is 30 (20 for practical sessional plus 10 marks for regularity, promptness,
viva- voce and record maintenance).
39

Pharm. D - I YEAR
(17T00106) REMEDIAL MATHEMATICS/BIOLOGY (THEORY)
REMEDIAL MATHEMATICS :
1. Scope and objectives: This is an introductory course in mathematics. This subjects deals
with the introduction to matrices, determinants, trigonometry, analytical geometry,
differential calculus, integral calculus, differential equations, laplace transform.
2. Upon completion of the course the student shall be able to : –

a. Know Trignometry, Analytical geometry, Matrices, Determinant, Integration, Differential
equation, Laplace transform and their applications;
b. solve the problems of different types by applying theory; and
c. appreciate the important applications of mathematics in pharmacy.
Text books
a. Differential calculus By Shantinarayan
b. Text book of Mathematics for second year pre- university by Prof.B.M.Sreenivas
Reference books
a. Integral calculus By Shanthinarayan
b. Engineering mathematics By B.S.Grewal
c. Trigonometry Part-I By S.L.Loney

Topics
1 i) Algebra : Determinants, Matrices
ii) Trigonometry : Sides and angles of a triangle, solution of triangles
2 Differential calculus: Limit of a function, Differential calculus,
Differentiation of a sum, Product, Quotient Composite, Parametric, exponential,
trigonometric and Logarithmic function. Successivedifferentiation, Leibnitz’s
theorem, Partial differentiation, Euler’s theorem on homogeneous functions of
two variables
3 Integral Calculus: Definite integrals, integration by substitution and by parts,
Properties of definite integrals.
4 Differential equations: Definition, order, degree, variable separable,homogeneous,
Linear, heterogeneous, linear, differential equation with constant coefficient, simultaneous
linear equation of second order.
5 i) Analytical Geometry:Points, Straight line, circle, parabola
ii) Laplace transform: Definition, Laplace transform of elementary functions, Properties
of linearity and shifting.
BIOLOGY :
1. Scope and objectives: This is an introductory course in Biology, which gives detailed study
of natural sources such as plant and animal origin. This subject has been introduces to the
pharmacy course in order to make the student aware of various naturally occurring drugs and
its history, sources, classification, distribution and the characters of the plants and animals.
This subject gives basic foundation to Pharmacognosy.
40
Text books
a. Text book of Biology by S.B.Gokhale
b. A Text book of Biology by Dr.Thulajappa and Dr.Seetaram.
Reference books
a. A Text book of Biology by B.V.Sreenivasa Naidu
b.A Text book of Biology by Naidu and Murthy
c.Botany for Degree students By A.C.Dutta.
d.Outlines of Zoology by M.Ekambaranathaayyer and T.N.Ananthakrishnan.
e.A manual for pharmaceutical biology practical by S.B.Gokhale and C.K.Kokate.

Topic
PART – A
01 Introduction
General organization of plants and its inclusions
Plant tissues
Plant kingdom and its classification
Morphology of plants
Root, Stem, Leaf and Its modifications
02 Inflorescence and Pollination of flowers
Morphology of fruits and seeds
Plant physiology
03 Taxonomy of Leguminosae, umbelliferae, Solanaceae, Lilliaceae, Zinziberaceae,
Rubiaceae
Study of Fungi, Yeast, Penicillin and Bacteria
PART-B
04 Study of Animal cell
Study animal tissues
Detailed study of frog
05 Study of Pisces, Raptiles, Aves
Genearal organization of mammals
Study of poisonous animals
41

Pharm. D - I YEAR
(17T00112) BIOLOGY (PRACTICAL)

Title:
1. Introduction of biology experiments
2. Study of cell wall constituents and cell inclusions
3. Study of Stem modifications
4. Study of Root modifications
5. Study of Leaf modifications
6. Identification of Fruits and seeds
7. Preparation of Permanent slides
8. T.S. of Senna, Cassia, Ephedra, Podophyllum.
9. Simple plant physiological experiments
10. Identification of animals
11. Detailed study of Frog
12. Computer based tutorials
Sessionals Annual
Synopsis 04 10
Viva 02 15
Max Marks 20 70
Duration 03 01
promptness, viva-voce and record maintenance.
42

Pharm. D - II YEAR
(17T00201) PATHOPHYSIOLOGY (THEORY)

1. Scope of the Subject: This course is designed to impart a thorough knowledge of the
relevant aspects of pathology of various conditions with reference to itspharmacological
applications, and understanding of basic Pathophysiological mechanisms. Hence it will
not only help to study the syllabus of pathology, but also to get baseline knowledge of its
application in other subject of pharmacy.
2. Objectives of the Subject : Upon completion of the subject student shall be able to –
a. describe the etiology and pathogenesis of the selected disease states;
b.name the signs and symptoms of the diseases; and
c.mention the complications of the diseases.
Text books (Theory)
a.Pathologic basis of disease by- Cotran, Kumar, Robbins
b.Text book of Pathology- Harsh Mohan
c.Text book of Pathology- Y.M. Bhinde
a. Clinical Pharmacy and Therapeutics; Second edition; Roger Walker; Churchill
Livingstone publication
3. Detailed syllabus and lecture wise schedule :

Chapter
1 i) Basic principles of cell injury and Adaptation
a) Causes, Pathogenesis and morphology of cell injury
b) Abnormalities in lipoproteinaemia, glycogen infiltration and glycogen
infiltration and glycogen infiltration and glycogen storage diseases
ii) Inflammation
a) Pathogenesis of acute inflammation, Chemical mediators in inflammation,
Types of chronic inflammation
b) Repairs of wounds in the skin, factors influencing healing of wounds
2 i) Diseases of Immunity
a) Introduction to Tand B cells
b) MHC proteins or transplantation antigens
c) Immune tolerance
-Hypersensitivity
Hypersensitivity type I, II, III, IV, Biological significance, Allergy due to food,
chemicals and drugs
-Autoimmunity
Criteria for autoimmunity, Classifications of autoimmune diseases in man,
mechanism of autoimmunity, Transplantation and immunologic tolerance,
allograft rejections, transplantation antigens, mechanism of rejection of
allograft.
-Acquired immune deficiency syndrome (AIDS)
- Amylodosis
ii) Infectious diseases :
Sexually transmitted diseases (HIV, Syphilis,Gonorrhea), Urinary tract infections,
Pneumonia, Typhoid, Tuberculosis, Leprosy, Malaria Dysentery (bacterial and
amoebic ), Hepatitis- infective hepatitis.
43
3 Cancer: differences between benign and malignanttumors, Histological

diagnosis of malignancy, invasions and metastasis, patterns of spread, disturbances of
growth of cells, classificatio n of tumors, general biology of tumors, spread of
malignant tumors, etiology and pathogenesis of cancer.
4 a) Types of shock, mechanisms, stages and management
b))Biological effects of radiation
c)Environmental and nutritional diseases
i)Air pollution and smoking- SO2,NO, NO2, and CO
ii)Protein calorie malnutrition, vitamins, obesity, pathogenesis of starvation.
5 i)Pathophysiology of common diseases
a.Parkinsonism
b.Schizophrenia
c.Depression and mania
d.Hypertension,
e.Stroke (ischaemic and hemorrhage)
f.Angina, CCF, Atherosclerosis, Myocardial infarction
g.Diabetes Mellitus
h.Peptic ulcer and inflammatory bowel diseases
i.Cirrhosis and Alcoholic liver diseases
j.Acute and chronic renal failure
k.Asthma and chronic obstructive airway diseases
Assignments :
Title of the Experiment
1 Chemical Mediators of inflammation
2 Drug Hypersensitivity
3 Cigarette smoking & its ill effects
4 Biological Effects of Radiation
5 Etiology and hazards of obesity
6 Complications of diabetes
7 Diagnosis of cancer
8 Disorders of vitamins
9 Methods in Pathology- Laboratory values of clinical significance
10 Pathophysiology of Dengue Hemorrhagic Fever (DHF)

1 Minimum & Maximum number of pages.
3. Assignment can be a combined presentation at the end of the academic year
5. Name and signature of the student
6. Time allocated for presentation may be 8+2Min.
44

Pharm. D - II YEAR
(17T00202) PHARMACEUTICAL MICROBIOLOGY (THEORY)

1. Scope of the Subject: Microbiology has always been an essential component of pharmacy
curriculum. This is because of the relevance of microbiology to pharmaceutical sciences and
more specifically to pharmaceutical industry. Pharmaceutical biotechnology is the logical
extension of pharmaceutical microbiology, which is expected to change the complete drug
product scenario in the future.
This course deals with the various aspects of microorganisms, its
classification,morphology, laboratory cultivation identification and maintenance. Its also
discusses with sterilization of pharmaceutical products, equipment, media etc. The course
furtherdiscusses the immunological preparations, diseases its transmission, diagnosis, control
and immunological tests.
2. Objectives of the Subject :

Upon completion of the subject student shall be able to –
a. know the anatomy, identification, growth factors and sterilization of microorganisms;
b. know the mode of transmission of disease causing microorganism, symptoms of disease,
and treatment aspect;
c. do estimation of RNA and DNA and there by identifying the source ;
d. do cultivation and identification of the microorganisms in the laboratory;
e. do identification of diseases by performing the diagnostic tests; and
f. appreciate the behavior of motility and behavioral characteristics of microorganisms.
Text books (Theory)

a. Vanitha Kale and KishorBhusari ― Applied Microbiology ‖ Himalaya Publishing house
Mumbai.
b. Mary Louis Turgeon ― Immunology and Serology in Laboratory Medicines‖ 2ndedition,
1996 Mosby- Year book inc St. Louis Missouri 63146.
c. Harsh Mohan, ― Text book of Pathology‖ 3rd edition, 1998, B-3 Ansari road Darya ganj
N. Delhi.

a. Prescot L.M., Jarley G.P Klein D.A ―Microbiology‖ 2nd- edition Mc Graw Hill
Company Inc
b. Rawlins E.A.‖Bentley’s Text Book of Pharmaceutics‖ B ailliereTindals 24-28 London
1988
c. Forbisher ― Fundamentals of Microbiology‖ Philidelphia W.B. Saunders.
d. Prescott L.M. Jarley G.P., Klein.D.A. ― Microbiology.‖2nd edition WMC Brown
Publishers, Oxford. 1993
e. War Roitt, Jonathan Brostoff, David male, ― Immunology‖3rd edition 1996, Mosby-year
book Europe Ltd, London.
f. Pharmacopoeia of India, Govt of India, 1996.
3. Detailed syllabus and lecture wise schedule:

Title of the topic
1 a) Introduction to the science of microbiology. Major divisions of microbial world and
Relationship among them.
b) Different methods of classification of microbes and study of Bacteria, Fungi, virus,
Rickettsiae, Spirochetes.
2 a) Nutritional requirements, growth and cultivation of bacteria and virus. Study of
different important media required for the growth of aerobic andanaerobic bacteria &
45
fungi. Differential media, enriched media and selective media, maintenance of lab
cultures.
b) Different methods used in isolation and identification of bacteria with emphasis to
different staining techniques and biochemical reactions. Counting of bacteria -Total and
Viable counting techniques.
3 a) Detailed study of different methods of sterilization including their merits and demerits.
Sterilization methods for all pharmaceutical products. Detailed study of sterility testing of
different pharmaceutical preparations .
Brief information on Validation.
b) Disinfectants- Study of disinfectants, antiseptics, fungicidal and virucidal agents
factors affecting their activation and mechanism of action. Evaluation of
bactericidal, bacteristatic,virucidal activities, evaluation of preservatives in
pharmaceutical preparations.
4 a) Immunology- Immunity, Definition, Classification, General principles of natural
immunity, Phagocytosis, acquired immunity( active and passive ) .
Antigens, chemical nature of antigens structure and formation of Antibodies, Antigen-
Antibody reactions. Bacterial exotoxins and
endotoxins. Significance of toxoids in active immunity, Immunization programme, and
importance of booster dose.
b) Diagnostic tests : Schick’s Test, Elisa test, Western Blot test, Southern BlotPCR Widal,
QBC, Mantaux Peripheral smear. Study of malarial parasite.
5 a) Microbial culture sensitivity Testing: Interpretation of results Principles
and methods of different microbiological assays, microbiological assay of
Penicillin, Streptomycin and vitamin B2 and B12. Standardisation of vaccines and sera.
b) Study of infectious diseases: Typhoid, Tuberculosis, Malaria, Cholera, Hepatitis,
Meningitis, Syphilis &Gonorrhea and HIV.
46

Pharm. D - II YEAR
(17T00207) PHARMACEUTICAL MICROBIOLOGY (PRACTICAL)

1 Study of apparatus used in experimental microbiology*.
2 Sterilisation of glass ware’s. Preparation of media and sterilisation.*
3 Staining techniques – Simple staining ; Gram’s staining ; Negative staining**
4 Study of motility characters*.
5 Enumeration of micro-organisms (Total and Viable)*
6 Study of the methods of isolation of pure culture.*
7 Bio chemical testing for the identification of micro*-organisms.
8 Cultural sensitivity testing for some micro-organisms.*
9 Sterility testing for powders and liquids.*
10 Determination of minimum inhibitory concentration.*
11 Microbiological assay of antibiotics by cup plate method.*
12 Microbiological assay of vitamins by Turbidometric method**
13 Determination of RWC.**
14 Diagnostic tests for some common diseases, Widal, malarial parasite.**
* Indicate minor experiment & ** indicate major experiment
Assignments:
1. Visit to some pathological laboratories & study the activities and equipment/instrumentsused
and reporting the same.
2. Visit to milk dairies (Pasturization) and microbial laboratories (other sterization
methods) & study the activities and equipment/instruments used and reporting the same.
3. Library assignments
a. Report of recent microbial techniques developed in diagnosing some common diseases.
b. Latest advancement developed in identifying, cultivating & handling of microorganisms.
Format of the assignment:


Sessionals Annual
Synopsis 05 15
Viva 02 15
Max Marks 20 70
promptness, viva- voce and record maintenance).
47

Pharm. D - II YEAR
(17T00203) PHARMACOGNOSY & PHYTOPHARMACEUTICALS (THEORY)
1. Scope and objectives: This subject has been introduced for the pharmacy course in order to
make the student aware of medicinal uses of various naturally occur ring drugs its history,
sources, distribution, method of cultivation, active constituents, medicinal uses, identification
tests, preservation methods, substitutes and adulterants.
2. Upon completion of the course student shall be able to:

a. under stand the basic principles of cultivation, collection and storage of crude drugs;
b. know the source, active constituents and uses of crude drugs; and
c. appreciate the applications of primary and secondary metabolites of the plant.
Text books
a. Pharmacognosy by G.E. Trease&W.C.Evans.
b. Pharmacognosy by C.K.Kokate,Gokhale&A.C.Purohit.
Reference books
a. Pharmacognosy by Brady &Tyler.E.
b. Pharmacognosy by T.E.Wallis.
c. Pharmacognosy by C.S. Shah &Qadery.
d. Pharmacognosy by M.A. Iyengar.

Topics
1 Introduction.
Definition, history and scope of Pharmacognosy.
Classification of crude drugs.
Cultivation, collection, processing and storage of crude drugs.
2 Detailed method of cultivation of crude drugs.
Study of cell wall constituents and cell inclusions.
Microscopical and powder Microscopical study of crude drugs.
3 Study of natural pesticides.
Detailed study of various cell constituents.
Carbohydrates and related products.
4 Detailed study carbohydrates containing drugs.(11 drugs)
Definition sources, method extraction, chemistry and method of analysis of lipids.
Detailed study of oils.
5 Definition, classification, chemistry and method of analysis of protein.
Study of plants fibers used in surgical dressings and related products.
Different methods of adulteration of crude drugs.
48

Pharm. D - II YEAR
(17T00208) PHARMACOGNOSY & PHYTOPHARMACEUTICALS

(PRACTICAL)
General Requirements: Laboratory Napkin, Observation Book 150 pages Zero brush, Needle,
Blade, Match box.
List of experiments:
1 Introduction of Pharmacognosy laboratory and experiments.
2 Study of cell wall constituents and cell inclusions.
3 Macro, powder and microscopic study of Datura.
4 Macro, powder and microscopic study of Senna.
5 Macro, powder and microscopic study of Cassia. cinnamon.
6 Macro, powder and microscopic study of Cinchona.
7 Macro, powder and microscopic study of Ephedra.
8 Macro, powder and microscopic study of Quassia.
9 Macro, powder and microscopic study of Clove
10 Macro, powder and microscopic study of Fennel.
11 Macro, powder and microscopic study of Coriander.
12 Macro, powder and microscopic study of Isapgol.
13 Macro, powder and microscopic study of Nux vomica.
14 Macro, powder and microscopic study of Rauwolfia.
15 Macro, powder and microscopic study of Liquorice.
16 Macro, powder and microscopic study of Ginger.
17 Macro, powder and microscopic study of Podophyllum.
18 Determination of Iodine value.
19 Determination of Saponification value and unsaponifiable matter.
20 Determination of ester value.
21 Determination of Acid value.
22 Chemical tests for Acacia.
23 Chemical tests for Tragacanth.
24 Chemical tests for Agar.
25 Chemical tests for Starch.
26 Chemical tests for Lipids.(castor oil, sesame oil, shark liver oil, bees wax)
27 Chemical tests for Gelatin.
Sessionals Annual
Synopsis 04 10
Viva 02 15
Max Marks 20 70
promptness, viva- voce and record maintenance.
49

Pharm. D - II YEAR
(17T00204) PHARMACOLOGY – I (THEORY)
1. Scope of the Subject: This subject will provide an opportunity for the student to learn
about the drug with regard to classification, pharmacodynamic and pharmacokinetic aspects,
adverse effects, uses, dose, route of administration, precautions,
contraindications and interaction with other drugs. In this subject, apart from general
pharmacology, drugs acting on autonomic nervous system, cardiovascular system, central nervous
system, blood and blood forming agents and renal system will be
taught. In addition to theoretical knowledge, the basic practical knowledge relevant to therapeutics
will be imparted.
2. Objectives of the Subject: Upon completion of the subject student shall be able to (Know, do,
appreciate) –
a. understand the pharmacological aspects of drugs falling under the above mentioned chapters;
b. handle and carry out the animal experiments;
c. appreciate the importance of pharmacology subject as a basis of therapeutics; and
d. correlate and apply the knowledge therapeutically.
Text books(Theory) (Author, Title, Edition, Publication Place, Publisher, Year of Publication)
a. Tripathi, K. D. Essentials of medical pharmacology. 4t h Ed, 1999. Publisher: Jaypee, Delhi.
b. Satoskar, R.S. and Bhadarkar, S.D. Pharmacology and pharmacotherapeutics. 16t h edition
(single volume), 1999. Publisher: Popular, Dubai.
c. Rang, H.P. & Dale, M.M. Pharmacology. 4t h edition, 1999. Publisher: Churchill Living
stone.
Reference books (Theory)(Author, Title, Edition, Publication Place, Publisher, Publication Year)
a. Goodman Gilman, A., Rall, T.W., Nies, A.I.S. and Taylor, P. Goodman and
Gilman’s The pharmacological Basis of therapeutics. 9t h Ed, 1996. Publisher Mc Graw Hill,
Pergamon press.
b. Craig, C.R.&Stitzel, R.E. Modern Pharmacology. Latest edition. Publisher : Little Brown.Co
c. Katzung, B.G. Basic and clinical pharmacology. Latest edition. Publisher: Prentice Hall, Int.
d. Shargel and Leon. Applied Biopharmaceutics and pharmacokinetics. Latest edition.
Publisher: Prentice Hall, London.
Text books (Practical) :

Kulkarni, S. K. and Dandia, P. C. Hand book of experimental pharmacology. Latest edition,
Publisher: Vallab, Delhi.
Reference books (Practical)

a. Macleod, L.J. Pharmacological experiments on intact preparations. Latest edition, Publisher:
Churchill livingstone.
b. Macleod, L.J. Pharmacological experiments on isolated preparations. Latest edition,
Publisher: Churchill livingstone.
c. Ghosh, M.N. Fundamentals of experimental pharmacology. Latest edition, Publisher:
Scientific book agency, Kolkata.
50
d. Ian Kitchen. Textbook of in vitro practical pharmacology. Latest edition, Publisher: Black
well Scientific.

Title of the topic
1. General Pharmacology
a) Introduction, definitions and scope of pharmacology
b) Routes of administration of drugs
c) Pharmacokinetics (absorption, distribution, metabolism and excretion)
d) Pharmacodynamics
e) Factors modifying drug effects
f) Drug toxicity - Acute, sub- acute and chronic toxicity.
g) Pre-clinical evaluations
h) Drug interactions
Note: The term Pharmacology used here refers to the classification, mechanism of action,
pharmacokinetics, pharmacodynamics, adverse effects, contraindications, Therapeutic uses,
interactions and dose and route of administration.
2. Pharmacology of drugs acting on ANS

a) Adrenergic and antiadrenergic drugs
b) Cholinergic and anticholinergic drugs
c) Neuromuscular blockers
d) Mydriactics and miotics
e) Drugs used in myasthenia gravis
f) Drugs used in Parkinsonism
3. i) Pharmacology of drugs acting on cardiovascular system

a) Antihypertensives
b) Anti-anginal drugs
c) Anti-arrhythmic drugs
d) Drugs used for therapy of Congestive Heart Failure
e) Drugs used for hyperlipidaemias
ii) Pharmacology of Drugs acting on Respiratory tract

a) Bronchodilators
b) Mucolytics
c) Expectorants
d) Antitussives
e) NasalDecongestants
4. Pharmacology of drugs acting on Central Nervous System

a) General anesthetics
b) Sedatives and hypnotics
c) Anticonvulsants
d) Analgesic and antiinflammatory agents
e) Psychotropic drugs
f) Alcohol and methyl alcohol
g) CNS stimulants and cognition enhancers
h) Pharmacology of local anaesthetics
51
5. i) Pharmacology of Hormones and Hormone antagonists

a) Thyroid and Antithyroid drugs
b) Insulin, Insulin analogues and oral hypoglycemic agents
c) Sex hormones and oral contraceptives
d) Oxytocin and other stimulants and relaxants
ii) Pharmacology of autocoids and their antagonists

a) Histamines and Antihistaminics
b) 5-Hydroxytryptamine and its antagonists
c) Lipid derived autocoids and platelet activating factor
52

Pharm. D - II YEAR
(17T00205) COMMUNITY PHARMACY (THEORY)

1. Scope: In the changing scenario of pharmacy practice in India, Community Pharmacists are
expected to offer various pharmaceutical care services. In order to meet this demand, students
will be learning various skills such as dispensing of drugs, responding to minor ailments by
providing suitable safe medication, patient counselling, health screening services for improved
patient care in the community set up.
2. Objectives: Upon completion of the course, the student shall be able to –

a. know pharmaceutical care services;
b. know the business and professional practice management skills in community pharmacies;
c. do patient counselling & provide health screening services to public in community pharmacy;
d. respond to minor ailments and provide appropriate medication;
e. show empathy and sympathy to patients; and
f. appreciate the concept of Rational drug therapy.
Text Books:
a. Health Education and Community Pharmacy by N.S.Parmar.
b. WHO consultative group report.
c. Drug store & Business management by Mohammed Ali &Jyoti.
Reference books:
a. Handbook of pharmacy – health care.Edt. Robin J Harman. The Pharmaceutical press.
b. Comprehensive Pharmacy Review – Edt. Leon Shargel. Lippincott Williams & Wilkins.
Special requirements:
1. Either the college is having model community pharmacy (meeting the schedule N
requirement) or sign MoU with at least 4-5 community pharmacies nearby to the college for
training the students on dispensing and counselling activities.
2. Special equipments like B.P apparatus, Glucometer, Peak flow meter, and apparatus for
cholesterol estimation.
3. Scheme of evaluation (80 Marks)
1. Synopsis 10
2. Major Experiment 30
(Counselling of patients with specific diseases – emphasis should be given on
Counselling introduction, content, process and conclusion)
3. Minor Experiment(Ability to measure B.P/ CBG / Lung function) 15
4. Prescription Analysis (Analyzing the prescriptions for probable drug interaction
andability to tell the management) 15
5. Viva – Voce 10
Lecture wise programme:
Topics
1 Definition, scope, of community pharmacy
Roles and responsibilities of Community pharmacist
Community Pharmacy Management
a) Selection of site, Space layout, and design
b) Staff, Materials- coding, stocking
c) Legal requirements
53
d) Maintenance of various registers

e) Use of Computers: Business and health care soft wares
2 Prescriptions – parts of prescription, legality& identification of medication related
problems like drug interactions.
Inventory control in community pharmacy
Definition, various methods of Inventory Control
ABC, VED, EOQ, Lead time, safety stock
Pharmaceutical care
Definition and Principles of Pharmaceutical care.
3 Patient counselling
Definition, outcomes, various stages, barriers, Strategies to overcome barriers Patient
information leaflets- content, design, & layouts, advisory labels
Patient medication adherence
Definition, Factors affecting medication adherence, role of pharmacist in improving the
adherence.
Health screening services
Definition, importance, methods for screening
Blood pressure/ blood sugar/ lung function and Cholesterol testing
4 OTC Medication- Definition, OTC medication list & Counselling
Health Education
WHO Definition of health, and health promotion, care for children, pregnant &breast
feeding women, and geriatric patients.
Commonly occurring Communicable Diseases, causative agents,
Clinical presentations and prevention of communicable diseases – Tuberculosis,
Hepatitis, Typhoid, Amoebiasis, Malaria, Leprosy,
Syphilis, Gonorrhea and AIDS
Balance diet, and treatment & prevention of deficiency disorders
Family planning – role of pharmacist
5 Responding to symptoms of minor ailments
Relevant pathophysiology, common drug therapy to,
Pain, GI disturbances (Nausea, Vomiting, Dyspepsia, diarrhea, constipation), Pyrexia,
Opthalmic symptoms, worms infestations.
Essential Drugs concept and Rational Drug The rapy Role of community
pharmacist
Code of ethics for community pharmacists
54

Pharm. D - II YEAR
(17T00206) PHARMACOTHERAPEUTICS - I (THEORY)

1. Scope of the Subject: This course is designed to impart knowledge and skills necessary for
contribution to quality use of medicines. Chapters dealt cover briefly pathophysiology and
mostly therapeutics of various diseases. This will enable the student to understand the
pathophysiology of common diseases and their management.
2. Objectives: At completion of this subject it is expected that students will be able to

understand –
a. the pathophysiology of selected disease states and the rationale for drug therapy;
b. the therapeutic approach to management of these diseases;
c. the controversies in drug therapy;
d. the importance of preparation of individualised therapeutic plans based on diagnosis;
e. needs to identify the patient-specific parameters relevant in initiating drug therapy,and
monitoring therapy (including alternatives, time-course of clinical and laboratory indices
of therapeutic response and adverse effects);
f. describe the pathophysiology of selected disease states and explain the rationale for drug
therapy;
g. summarise the therapeutic approach to management of these diseases including reference
to the latest available evidence;
h. discuss the controversies in drug therapy;
i. discuss the preparation of individualised therapeutic plans based on diagnosis; and
j. identify the patient-specific parameters relevant in initiating drug therapy, and monitoring
therapy (including alternatives, time-course of clinical and laboratory indices of
therapeutic response and adverse effects).
Text Books
a. Clinical Pharmacy and Therapeutics - Roger and Walker, Churchill Livingstone
publication.
b. Pharmacotherapy: A Pathophysiologic approach - Joseph T. Dipiro et al. Appleton &
Lange.
Reference Books
a. Pathologic basis of disease - Robins SL, W.B.Saunders publication.
b. Pathology and therapeutics for Pharmacists: A Basis for Clinical Pharmacy Practice -
Green and Harris, Chapman and Hall publication.
c. Clinical Pharmacy and Therapeutics - Eric T. Herfindal, Williams and Wilkins
Publication.
d. Applied Therapeutics:The clinical Use of Drugs. Lloyd Young and Koda-Kimble MA
e. Avery’s Drug Treatment, 4th Edn, 1997, Adis International Limited.
f. Relevant review articles from recent medical and pharmaceutical literature.

Etiopathogenesis and pharmacotherapy of diseases associated with following systems/
diseases
Title of the topic

1. Cardiovascular system: Hypertension, Congestive cardiac failure,
55
Angina Pectoris, Myocardial infarction, Hyperlipidaemias , Electrophysiology of heart

and Arrhythmias
Respiratory system: Introduction to Pulmonary function test, Asthma, Chronic

obstructive airways disease, Drug induced pulmonary diseases
2. Endocrine system: Diabetes, Thyroid diseases, Oral contraceptives, Hormone

replacement therapy, Osteoporosis
3. General prescribing guidelines for

a. Paediatric patients
b. Geriatric patients
c. Pregnancy and breast feeding
4. Ophthalmology: Glaucoma, Conjunctivitis- viral & bacterial
5. Introduction to rational drug use

Definition, Role of pharmacist Essential drug concept Rational drug formulations
56

Pharm. D - II YEAR
(17T00209) PHARMACOTHERAPEUTICS - I (PRACTICAL)

Practicals: 3 Hrs. /Week
Hospital postings in various departments designed to complement the lectures by providing

practical clinical discussion; attending ward rounds; follow up the progress and changes made in
drug therapy in allotted patients; case presentation upon discharge. Students are required to
maintain a record of cases presented and the same should be submitted at the end of the course for
evaluation. A minimum of 20 cases should be presented and recorded covering most common
diseases.
Assignments :
Students are required to submit written assignments on the topics given to them. Topics allotted
should cover recent developments in drug therapy of various diseases. A minimum of THREE
assignments [1500 – 2000 words] should be submitted for evaluation.


Sessionals Annual
Synopsis 05 15
Viva 02 15
Max Marks 20 70
57

Pharm. D - III YEAR
(17T00301) PHARMACOLOGY – II (THEORY)

1. Scope of the Subject: This subject will provide an opportunity for the student to learn
about the drug with regard to classification, pharmacodynamic and pharmacokinetic aspects,
adverse effects, uses, dose, route of administration, precautions, contraindications and
interaction with other drugs. In this subject, drugs acting on autacoids, respiratorysystem, GIT,
immune system and hormones, and pharmacology of autocoids and hormones will be
concentrated. In addition, pharmacology of chemotherapeutic agents, vitamins, essential
minerals and principles of toxicology are also taught. In addition to theoretical knowledge, the
basic practical knowledge relevant to therapeutics will be imparted.
2. Objectives of the Subject Upon completion of the subject student shall be able to:
a. understand the pharmacological aspects of drugs falling under the above mentioned
chapters,
b. carry out the animal experiments confidently,
c. appreciate the importance of pharmacology subject as a basis of therapeutics, and
d. correlate and apply the knowledge therapeutically.
Text books (Theory)

a. Tripathi, K. D. Essentials of medical pharmacology. 4t h edition, 1999. Publisher: Jaypee,
Delhi.
b. Satoskar, R.S. and Bhadarkar, S.D. Pharmacology and pharmacotherapeutics.16th edition
(single volume), 1999. Publisher: Popular, Dubai.
c. Rang, H.P. and Dale, M.M. Pharmacology. 4t h edition, 1999. Publisher: Churchill Living
stone.

a. Goodman Gilman, A., Rall, T.W., Nies, A.I.S. and Taylor, P. Goodman and Gilman’sThe
pharmacological Basis of therapeutics. 9t h edition, 1996. Publisher: Mc Graw Hill,
Pergamon press.
b. Craig, C.R. and Stitzel, R.E. Modern Pharmacology. Latest edition. Publisher: Little
Brown and company.
c. Katzung, B.G. Basic and clinical pharmacology. Latest edition. Publisher: Prentice Hall,
International.
d. Gupta, P.K. and Salunkhe, D.K. Modern Toxicology. Volume I, II and III. Latest edition.
Publisher: B.V. Gupta, Metropolitan Book Co. (p) Ltd, New Delhi.
Text books (Practical)

Kulkarni, S. K. and Dandia, P. C. Hand book of experimental pharmacology. Latest edition,
Publisher: Vallab, Delhi.
Reference books (Practical) :

a. Macleod, L.J. Pharmacological experiments on intact preparations. Latest edition,
b. Macleod, L.J. Pharmacological experiments on isolated preparations. Latest edition,
58
c. Ghosh, M.N. Fundamentals of experimental pharmacology. Latest edition, Publisher:

Scientific book agency, Kolkata.
d. Ian Kitchen. Textbook of in vitro practical pharmacology. Latest edition, Publisher: Black
well Scientific.
Title of the topic

1. i) Pharmacology of Drugs acting on Blood and blood forming agents
a)Anticoagulants
b)Thrombolytics and antiplatelet agents
c)Haemopoietics and plasma expanders
ii) Pharmacology of drugs acting on Renal System
a)Diuretics
b)Antidiuretics
2. Chemotherapy
a)Introduction
b)Sulfonamides and co-trimoxazole
c)Penicillins and Cephalosporins
d) Tetracyclins and Chloramphenicol
e)Macrolides, Aminoglycosides, Polyene& Polypeptide antibiotics
f)Quinolines and Fluroquinolines
g)Antifungal antibiotics
h)Antiviral agents
i)Chemotherapy of tuberculosis and leprosy
j)Chemotherapy of Malaria
k)Chemotherapy of protozoal infections (amoebiasis, Giardiasis)
l)Pharmacology of Anthelmintic drugs
m)Chemotherapy of cancer (Neoplasms)
3 i) Immunopharmacology: Pharmacology of immunosuppressants and stimulants

ii) Principles of Animal toxicology: Acute, sub acute and chronic toxicity
4. The dynamic cell:The structures and functions of the components of the cell
a) Cell and macromolecules: Cellular classification, subcellular organelles, macromolecules,
large macromolecular assemblies
b) Chromosome structure: Pro and eukaryotic chromosomestructures, chromatin
structure, genome complexity, the flow of genetic information.
c) DNA replication: General, bacterial and eukaryotic DNA replication.
d) The cell cycle: Restriction point, cell cycle regulators and modifiers.
e) Cell signaling: Communication between cells and theirenvironment, ion-channels,
signal transduction pathways (MAP kinase, P38 kinase, JNK, Ras and PI3-kinase
pathways, biosensors.
5. The Gene:Genome structure and function:

a) Gene structure: Organization and elucidation of genetic code.
b) Gene expression: Expression systems (pro and eukaryotic),genetic elements that control
gene expression (nucleosomes, histones, acetylation, HDACS, DNA binding protein
families.
59
c) Transcription and Transcription factors: Basic principles oftranscription in pro and

eukaryotes. Transcription factors that regulate transcription in pro and eukaryotes.
RNA processing:rRNA, tRNA and mRNA processing.

Protein synthesis: Mechanisms of protein synthesis, initiation in eukaryotes, translation
control and post-translation events
Altered gene functions: Mutations, deletions, amplifications, LOH, traslocations, trinucleotide
repeats and other genetic abnormalities. Oncogenes and tumor suppressor genes.
The gene sequencing, mapping and cloning of human disease genes. Introduction to gene
therapy and targeting.
Recombinant DNA technology: principles. Processes (gene transfer technology) and
applications
Books:
1 Molecular Biology of the Cell by Alberts B., Bray, D., Lewis, J., Raff M., Roberts, K and
Watson, JD, 3rd edition.
2 Molecular Cell Biology ByLodish, H., Baltimore, D., Berk, A et al., 5t h edition.
3 Molecular Biology by Turner, PC., McLennan, AG., Bates, AD and White MRH 2nd edition.
4 Genes VIII by Lewin, B., (2004)
5 Pharmaceutical Biotechnology, by Crommelin, DJA and Sindelar RD (1997)
6 Recombinant DNA by Watson, JD., Gilman, M., et al., (1996)
7 Biopharmaceutical: Biochemistry and Biotechnology by Walsh, G., (1998)
60

Pharm. D - III YEAR
(17T00307) PHARMACOLOGY – II (PRACTICAL)

1. Study of laboratory animals and their handling (a. Frogs, b. Mice, c. Rats, d. Guinea pigs, e.
Rabbits).
2. Study of physiological salt solutions used in experimental pharmacology.
3. Study of laboratory appliances used in experimental pharmacology.
4. Study of use of anesthetics in laboratory animals.
5. To record the dose response curve of Ach using isolated ileum/rectus abdominis muscle
preparation.
6. To carry out bioassay of Ach using isolated ileum/rectus abdominis muscle preparation by
interpolation method.
7. To carry out bioassay of Ach using isolated ileum/rectus abdominis muscle preparation by
three point method.
8. To record the dose response curve of Histamine using isolated guinea-pig ileum preparation.
9. Study of agonistic and antagonistic effects of drugs using isolated guinea-pig ileum
preparation.
10. To carry out bioassay of Histamine using isolated guinea-pig ileum preparation by
interpolation method.
11. To carry out bioassay of Histamine using guinea-pig ileum preparation by three point method.
12. To study the routes of administration of drugs in animals (Rats, Mice, Rabbits).
13. Study of theory, principle, procedure involved and interpretation of given results for the
following experiments:
a) Analgesic property of drug using analgesiometer.
b) Antiinflammatory effect of drugs using rat-paw edema method.
c) Anticonvulsant activity of drugs using maximal electroshock and pentylenetetrazole methods.
d) Antidepressant activity of drugs using pole climbing apparatus and pentobarbitone induced
sleeping time methods.
e) Locomotor activity evaluation of drugs using actophotometer and rotorod.
f) Cardiotonic activity of drugs using isolated frog heart and mammalian heart preparations.

Sessionals Annual
Synopsis 04 10
Major Experiment (Bioassay) 08 30
Minor Experiment (Interpretation of 04 10
given Graph or simulated experiment)
Viva 02 10
Max Marks 20 70
Duration 3hrs 4hrs
61

Pharm. D - III YEAR
(17T00302) PHARMACEUTICAL ANALYSIS (THEORY)

1. Quality Assurance:
a. Introduction, sources of quality variation, control of quality variation.
b. Concept of statistical quality control.
c. Validation methods- quality of equipment, validation of equipment and validation of
analytical instruments and calibration.
d. GLP, ISO 9000.
e. Total quality management, quality review and documentation.
f. ICH- international conference for harmonization-guidelines.
g. Regulatory control.
2. Chromatography:
Introduction, history, classification, separation techniques, choice of methods.
The following techniques be discussed with relevant examples of pharmaceutical products
involving principles and techniques of separation of drugs from excipients.
a. Column Chromatography: Adsorption column chromatography, Operational
technique, frontal analysis and elution analysis. Factors affecting column efficiency,
applications and partition chromatography.
b. TLC: Introduction, principle, techniques, Rf value and applications.
c. PC: Introduction, principle, types of paper chromatography, preparation techniques,
development techniques, applications.
d. Ion-exchange chromatography : Introduction, principles, types of ion
exchange synthetic resins, physical properties, factors affecting ion
exchange, methodology and applications.
e. HPLC: Introduction, theory, instrumentation, and applications.
f. HPTLC: Introduction, theory, instrumentation, and applications.
g. Gas Chromatography: Introduction, theory, instrumentation-carriergases, types of
columns, stationary phases in GLC & GSC. Detectors-Flame ionization detectors,
electron capture detector, thermal conductivity detector. Typical gas chromatogram,
derivatisation techniques, programmed temperature gas chromatography, applications.
h. Electrophoresis: Principles of separation, equipment for paper and gel electrophoresis,
and application.
i. Gel filtration and affinity chromatography: Introduction, technique, applications.
3. Electrometric Methods:
Theoretical aspects, instrumentation, interpretation of data/spectra and analytical applications
be discussed on the following topics.
a. Potentiometry: Electrical potential, electrochemical cell, reference electrodes, indicator
electrodes, measurement of potential and pH, construction and workingof electrodes,
Potentiometric titrations, methods of detecting e nd point, Karl Fischer titration.
b. Conductometry: Introduction, conductivity cell, conductometric titrations and
applications.
c. Polarography: Instrumentation, DME, residual current, diffusion current andlimiting
current, polarographic wave, Ilkovic’s equation, Effect of oxygen on polarographic
wave, Polarographic maxima and suppressors and applications.
d. Amperometric Titrations: Introduction, types of electrodes used, reference and
indicator electrode, instrumentation, titration procedure, advantages and disadvantages
of Amperometry over potentiometry. Pharma applications.
62
4. Spectroscopy:
Theoretical aspects, instrumentation, elements of interpretation of data/spectra and application
of analytical techniques be discussed on:
a. Absorption Spectroscopy:
- Theory of electronic, atomic and molecular spectra. Fundamental laws of photometry,
Beer-Lambert’s Law, application and its deviation,limitation of Beer law, application
of the law to single and multiple component analysis, measurement of equilibrium
constant and rate constant by spectroscopy. Spectra of isolated
chromophores,auxochromes, batho-chromic shift, hypsochromic shift, hyperchromic
and hypochromic effect, effect of solvent on absorption spectra,molecular structure and
infrared spectra.
Instrumentation – Photometer, U.V.-Visible spectrophotometer –
sources of U.V.-Visible radiations, collimating systems,
monochromators, samples cells and following detectors-Photocell,Barrier layer cell,
Phototube, Diode array, applications of U.V.-Visible spectroscopy in pharmacy and
spectrophotometric titrations.
- Infrared Spectroscopy: Vibrational transitions, frequency – structure correlations,

Infrared absorption bands, Instrumentation–IR spectro-meter – sources of IR,
Collimating systems, monochromators, sample cells, sample handling in IR
spectroscopy and detectors– Thermocouple, Golay Cells, Thermistor, Bolometer,
Pyroelectric detector, Applications of IR in pharmacy.
- Fluorimetric Analysis: Theory, luminescence, factors affecting fluorescence,

quenching. Instrumentation, Applications, fluorescentindicators, study of
pharmaceutically important compounds estimated by fluorimetry.
b. Flame Photometry: Theory, nebulisation, flame and flame temperature,interferences,

flame spectrometric techniques and instrumentation and pharmaceutical applications.
c. Atomic Absorption Spectrometry: Introduction, Theory, types of electrodes,

instrumentation and applications.
d. Atomic Emission Spectroscopy: Spectroscopic sources, atomic emission spectrometers,

photographic and photoelectric detection.
5. a. NMR& ESR (introduction only): Introduction, theoretical aspects and applications.
b. Mass Spectroscopy: (Introduction only) – Fragmentation, types of ions produced mass

spectrum and applications.
c. Polarimetry: (Introduction only) – Introduction to optical rotatory dispersion, circular

dichroism, polarimeter.
d. X-RAY Diffraction: (Introduction only) – Theory, reciprocal lattice concept, diffraction

patterns and applications.
e. Thermal Analysis: Introduction, instrumentation, applications, and DSC and DTA.
63

Pharm. D - III YEAR
(17T00308) PHARMACEUTICAL ANALYSIS (PRACTICAL)

1. Separation and identification of Amino Acids by Paper Chromatography.
2. Separation and identification of Sulpha drugs by TLC technique.
3. Effect of pH and solvent on the UV spectrum of given compound.
4. Comparison of the UV spectrum of a compound with that of its derivatives.
5. Determination of dissociation constant of indicators using UV-Visible spectroscopy.
6. Conductometric titration of mixture of acids with a strong base.
7. Potentiometric titration of aacid with a strong base.
8. Estimation of drugs by Fluorimetric technique.
9. Study of quenching effect in fluorimetry.
10. Colourimetric estimation of Supha drugs using BMR reagent.
11. Simultaneous estimation of two drugs present in given formulation.
12.Assay of Salicylic Acid by colourimetry.
13.Determination of Chlorides and Sulphates in Calcium gluconate by Nepheloturbidimetric
Method.
14.Determination of Na/K by Flame Photometry.
15. Determination of pKa using pH meter.
16. Determination of specific rotation.
17. Comparison of the IR spectrum of a compound with that of its derivatives.
18. Demonstration of HPLC.
19. Demonstration of HPTLC.
20. Demonstration of GC-MS.
21. Demonstration of DSC.
22. Interpretation of NMR spectra of any one compound.
Reference Books:
1. Text Book of Pharm. Analysis by Higuchi. T and Hasen. E. B., New York Inter Science
Publishers.
2. Quantitative Pharma. Analysis by Jenkins, The Blakiston division, New York.
3. Quantitative Drug Analysis, by Garrot. D, Chapman & Hall Ltd., London.
4. Undergraduate Instrumental Analysis by James. E., CBS Publishers.
5. Instrumental Analysis by Willard and Merritt, EWP, East West Press Ltd.,
Delhi/Madras.
6. Pharm Analysis by Skoog and West, Sounders Manipal College Publishing.
7. Text Book of Chemical Analysis, by A.I.Vogel, ELBS with Macmillan press,
Hampshire.
8. Textbook of Pharm. Analysis by K.A.Connors, John Wiley & Sons, New York,
Brisbane, Singapore.
9. Textbook of Pharm. Analysis (Practical) by Beckett &Stenlake, CBS
Publishers, Delhi.
10. Textbook of Drug Analysis by P.D. Sethi., CBS Publishers, Delhi.
11. Spectroscopy by Silverstein, John & Wiley & Sons. Inc., Canada & Singapore.
12. How to practise GMP-A Plan for total quality control by P.P. Sharma,
VandanaPublications, Agra.
13. The Science & Practice of Pharmacy by Remington Vol-I & II, Mack Publishing Co.
Pennsylvania.
14. TLC by Stahl, Spring Verlay.
15. Text Book of Pharm. Chemistry by Chatten, CBS Publications.
16. Spectroscopy by William Kemp, ELBS with Macmillan Press, Hampshire.
17. I.P.-1996, The Controller of Publications, New Delhi.
18. BPC- Dept. of Health, U.K. for HMSO.
19. USP - Mack Publishing Co., Easton, PA.
64
20. The Extra Pharmacopoeia – The Pharm. Press, London.
Practicals
1 Study of agonistic and antagonistic effects of drugs using Guinea-pig ileum preparation.**
2 To study the effects of drugs on intestinal motility using frog’s esophagus model*
3 To study the effects of drugs using rat uterus preparation.**
4 To study the anticonvulsant property of drugs (any one model).*
5 To study antihistaminic property of drug using histamine induced anaphylactic reaction in
guinea pigs.
6 To study the apomorphine- induced compulsive behaviour (stereotypy) in mice.*
7 To study the muscle relaxant property of diazepam in mice using rotarod apparatus.*
8 To study the antiinflammatory property of indomethacin against carrageenan- induced paw
oedema.**
9 To study the anxiolytic effect of diazepam in mice using mirrored-chamber apparatus.**
10 To demonstrate the effect of various drugs on the blood pressure and respiration of
anaesthetized dog.
11 To study the effect of anthelmintics on earthworms.
12 To study the taming effect of chlorpromazine.*
13 To study the effects of drugs on vas deferense of the male rat.**

14 To study the effect of drugs on pesticide toxicity using rats as model.
15 To study the effect of drugs on heavy metal toxicity.
**indicate major experiment & * indicate minor experiment

Sessionals Annual
Synopsis 05 15
15
Viva 02 15
Max Marks 20 70
Duration 3hrs 4hrs
65

Pharm. D - III YEAR
(17T00303) PHARMACOTHERAPEUTICS – II (THEORY)

1. Scope of the Subject: This course is designed to impart knowledge and skills necessary for
contribution to quality use of medicines. Chapters dealt cover briefly pathophysiologyand
mostly therapeutics of various diseases. This will enable the student to understand the
pathophysiology of common diseases and their management.
2. Objectives of the Subject Upon completion of the subject student shall be able to –
a. know the pathophysiology of selected disease states and the rationale for drug therapy
b. know the therapeutic approach to management of these diseases;
c. know the controversies in drug therapy;
d. know the importance of preparation of individualised therapeutic plans based on
diagnosis; and
e. appreciate the needs to identify the patient-specific parameters relevant in initiating drug
therapy, and monitoring therapy (including alternatives, time-course of clinical and
laboratory indices of therapeutic response and adverse effects).
Text books (Theory)

Clinical Pharmacy and Therapeutics - Roger and Walker, Churchill Livingstone publication

a. Pharmacotherapy: A Pathophysiologic approach - Joseph T. Dipiro et al. Appleton &
Lange
b. Clinical Pharmacy and Therapeutics - Eric T. Herfindal, Williams and Wilkins
Publication
c. Applied Therapeutics: The clinical Use of Drugs. Lloyd Young and Koda-Kimble MA]

Etiopathogenesis and pharmacotherapy of diseases associated with following systems /
diseases –
Title of the topic

1. Infectious disease: Guidelines for the rational use of antibiotics and surgical Prophylaxis,
Tuberculosis, Meningitis, Respiratory tract infections, Gastroenteritis,Endocarditis,
Septicemia, Urinary tract infections, Protozoal infection- Malaria, HIV & Opportunistic
infections, Fungal infections, Viral infections, Gonarrhoea and Syphillis
2 Musculoskeletal disorders
Rheumatoid arthritis, Osteoarthritis, Gout, Spondylitis, Systemic lupus erythematosus.
3 Renal system
Acute Renal Failure, Chronic Renal Failure, Renal Dialysis, Drug induced renal disorders
4 Oncology:Basic principles of Cancer therapy, General introduction to cancer
chemotherapeutic agents, Chemotherapy of breast cancer, leukemia. Management of
chemotherapy nausea and emesis
5 Dermatology: Psoriasis, Scabies, Eczema, Impetigo
66

Pharm. D - III YEAR
(17T00309) PHARMACOTHERAPEUTICS – II (PRACTICAL)
Practicals: 3 Hrs. /Week
Hospital postings in various departments designed to complement the lectures by providing

practical clinical discussion; attending ward rounds; follow up the progress and changes made in
drug therapy in allotted patients; case presentation upon discharge. Students are required to
maintain a record of cases presented and the same should be submitted at the end of the course for
evaluation.
The student shall be trained to understand the principle and practice involved in selection of drug
therapy including clinical discussion.
A minimum of 20 cases should be presented and recorded covering most common diseases.
Assignments :
Format of the assignment :


Sessionals Annual
Synopsis 05 15
Viva 02 15
Max Marks 20 70
67

Pharm. D - III YEAR
(17T00304) PHARMACEUTICAL JURISPRUDENCE (THEORY)
1. Scope of the Subject: (4-6 lines): This course exposes the student to several important
legislations related to the profession of pharmacy in India. The Drugs and Cosmetics Act,
along with its amendments are the core of this course. Other acts, which are covered, include
the Pharmacy Act, dangerous drugs, medicinal and toilet preparation Act etc. Besides this the
new drug policy, professional ethics, DPCO, patent and design Act will be discussed.
2. Objectives of the Subject: Upon completion of the subject student shall be able to (Know,
do, and appreciate) –
a. practice the Professional ethics;
b. understand the various concepts of the pharmaceutical legislation in India;
c. know the various parameters in the Drug and Cosmetic Act and rules ;
d. know the Drug policy, DPCO, Patent and design act;
e. understand the labeling requirements and packaging guidelines for drugs and cosmetics;
f. be able to understand the concepts of Dangerous Drugs Act, Pharmacy Act and Excise
duties Act; and
g. other laws as prescribed by the Pharmacy Council of India from time to time including
International Laws.
Text books (Theory)
Mithal , B M. Textbook of Forensic Pharmacy. Calcutta:National; 1988.
a. Singh, KK, editor. Beotra’s the Laws of Drugs, Medicines & cosmetics. Allahabad: Law
Book House; 1984.
b. Jain, NK. A Textbook of forensic pharmacy. Delhi: Vallabhprakashan ; 1995.
c. Reports of the Pharmaceutical enquiry Committee
d. I.D.M.A., Mumbai. DPCO 1995
e. Various reports of Amendments.
f. Deshapande, S.W. The drugs and magic remedies act 1954 and rules 1955. Mumbai:
Susmit Publications; 1998.
g. Eastern Book Company .The narcotic and psychotropic substances act 1985, Lucknow:
Eastern; 1987.

Title of the topic
1. Pharmaceutical Legislations – A brief review.

Principle and Significance of professional ethics. Critical study of the code of pharmaceutical
ethics drafted by PCI.
2. Drugs and Cosmetics Act, 1940,and its rules 1945.
Objectives, Legal definition, Study of Schedule’s with reference to Schedule B,
C&C1, D, E1, F&F1, F2, F3, FF, G, H, J, K, M, N, P, R, V, W, X, Y.
Sales, Import, labeling and packaging of Drugs And Cosmetics Provisions Relating to
Indigenous Systems.
68
Constitution and Functions of DTAB,DCC,CDL. Qualification and duties –Govt. analyst and
Drugs Inspector.
3. Pharmacy Act –1948.
Objectives Legal Definitions, General Study, Constitution and Functions of State & Central
Council, Registration & Procedure, ER.
Medicinal and Toilet Preparation Act –1955.
Objectives, Legal Definitions, Licensing, Bonded and Non Bonded Laboratory, Ware
Housing, Manufacture of Ayurvedic, Homeopathic, Patent &Proprietory Preparations.
4. Narcotic Drugs and Psychotropic substances Act-1985 and Rules. Objectives, Legal
Definitions, General Study, Constitution and Functions of narcotic & Psychotropic
Consultative Committee, National Fund for Controlling the Drug Abuse, Prohibition, Control
and regulations, Schedules to the Act.
Study of Salient Features of Drugs and magic remedies Act and its rules.
Study of essential Commodities Act Relevant to drugs price control Order.
5. Drug Price control Order & National Drug Policy (Current).
Prevention Of Cruelty to animals Act-1960.
Patents & design Act-1970.
Brief study of prescription and Non-prescription Products.
4. Assignments:
1. Minimum & Maximum number of pages
2. It shall be a computer draft copy
6. Time allocated for presentation may be 8+2 Min
Case studies relating to

1. Drugs and Cosmetics Act and rules along with its amendments, Dangerous Drugs Act,
Medicinal and Toilet preparation Act, New Drug Policy, Professional Ethics, Drugs
(Price control) Order, Patent and Design Act.
2. Various prescription and non-prescription products.
3. Medical and surgical accessories.
4. Diagnostic aids and appliances available in the market.
69

Pharm. D - III YEAR
(17T00305) MEDICINAL CHEMISTRY (THEORY)
Theory : 3 Hrs. /Week
1. Modern concept of rational drug design: A brief introduction to Quantitative Structure

Activity Relationship (QSAR), prodrug, combinatorial chemistry and computer aided
drug design (CADD) and concept of antisense molecules.
A study of the development of the following classes of drugs including SAR,

mechanism of action, synthesis of important compounds, chemical nomenclature,
brand names of important marketed products and their side effects.
2. Anti- infective agents

a) Local anti- infective agents
b) Preservatives
c) Antifungal agents
d) Urinary tract anti- infectives
e) Antitubercular agents
f) Antiviral agents and Anti AIDS agents
g) Antiprotozoal agents
h) Anthelmentics
i) Antiscabies and Antipedicular agents
3. Sulphonamides and sulphones

Antimalarials
Antibiotics
4. Antineoplastic agents
Cardiovascular agents
a) Antihypertensive agents
b) Antianginal agents and vasodilators
c) Antiarrhythmic agents
d) Antihyperlipidemic agents
e) Coagulants and Anticoagulants
f) Endocrine
5. Hypoglycemic agents
Thyroid and Antithyroid agents
Diureties
Diagnostic agents
Steroidal Hormones and Adrenocorticoids
70

Pharm. D - III YEAR
(17T00310) MEDICINAL CHEMISTRY (PRACTICAL)
Practical :3 Hrs./Week
1. Assays of important drugs from the course content.

2. Preparation of medicinally important compounds or intermediates required for
synthesis of drugs.
3. Monograph analysis of important drugs.
4. Determination of partition coefficients, dissociation constants and molar refractivity of
compounds for QSAR analysis.
Reference Books:
a. Wilson and Gisvold’s Text book of Organic, Medicinal and Pharmaceutical
Chemistry, Lippincott-Raven Publishers-New York, Philadelphia.
b. William.O.Foye, Principles of Medicinal Chemistry, B.I. Waverly Pvt. Ltd., New
Delhi.
c. Burgers, Medicinal Chemistry, M.E.,WellyMed.Chemistry M.E. WalffedJohnwilley
and Sons, Wiley-interscience Publication, New York, Toranto.
d. A Text Book of Medicinal Chemistry Vol. I and II by Surendra N. Pandeya, S.G.
Publisher, 6, Dildayal Nagar, Varanasi -10.
e. Indian Pharmacopoeia 1985 and 1996. The Controller of Publications, Civil Lines,
Delhi - 54.
f. Current Index of Medical Specialities (CIMS) and MIMS India, MIMS, A.E. Morgan
Publications (I) Pvt. Ltd, New Delhi-19.
g. Organic Drug Synthesis-LedniserMitzsher Vol. I and II.
h. Pharmaceutical Chemistry drug Synthesis Vol. I and II by H. J. Roth and A.
Kleemann.
i. The Science and Practice of Pharmacy Vol. 1 and 2, Remington, MACK Publishing
company, Easton, Pennsylvania.
71

Pharm. D - III YEAR
(17T00306) PHARMACEUTICAL FORMULATIONS (THEORY)
Theory :2 Hrs. /Week
1. Scope of the Subject: Scope and objectives of the course: Subject deals with the formulation and
evaluation of various pharmaceutical dosage forms.
2. Objectives of the Subject: Upon completion of the subject student shall be able to (Know, do,
appreciate) –
a. understand the principle involved in formulation of various pharmaceutical dosage forms;

b. prepare various pharmaceutical formulation;
c. perform evaluation of pharmaceutical dosage forms; and
d. understand and appreciate the concept of bioavailability and bioequivalence, their role in
clinical situations.
Text books (Theory)

a. Pharmaceutical dosage forms, Vol, I,II and III by lachman
b. Rowlings Text book of Pharmaceutics
c. Tutorial Pharmacy – Cooper &Gun

a. Remington’s Pharmaceutical Sciences
b. USP/BP/IP
Title of the topic
1. Pharmaceutical dosage form- concept and classification

Tablets: Formulation of different types of tablets, tablet excipients, granulationtechniques
quality control and evaluation of tablets. Tablet coating, Type of coating, quality control tests for
coated tablet.
2. Capsules; Production and filling of hard gelatin capsules, Raw material for shell,
finishing, quality control tests for capsules. Production and filling of soft gelatine capsules, quality
control tests for soft gelatin capsules.
3. Liquid orals: Formulation and evaluation of suspensions, emulsions and solutions.Stability of
these preparations
Parenterals Introduction Containers used for Parenterals (including official tests) Formulation of
large and small volume Parenterals Sterilization
4. Ophthalmic preparations(Semi – Solids): Introduction and classification Factorsaffecting
absorption and anatomy of skin Packaging storage and labeling, Ointments Types of Ointment Base
Preparation of ointment, Jellies Types of jellies Formulation of jellies Suppositories, Method of
preparation, Types Packaging
5. Definition and concept of Controlled and novel Drug delivery systems with available examples, viz.
parentral, trans dermal, buccal, rectal, nasal, implants, ocular
72

Pharm. D - III YEAR
(17T00311) PHARMACEUTICAL FORMULATIONS (PRACTICAL)
Practical : 3 Hrs./Week
1. Manufacture of Tablets
a. Ordinary compressed tablet-wet granulation
b. Tablets prepared by direct compression.
c. Soluble tablet.
d. Chewable tablet.
2. Formulation and filling of hard gelatin capsules
3. Manufacture of parenterals
a. Ascorbic acid injection
b. Calcium gluconate injection
c. Sodium chloride infusion.
d. Dextrose and Sodium chloride injection/ infusion.
4. Evaluation of Pharmaceutical formulations (QC tests)
a. Tablets
b. Capsules
c. Injections
5. Formulation of two liquid oral preparations and evaluation by assay
a. Solution: Paracetamol Syrup
b. Antacid suspensions- Aluminum hydroxide gel
6. Formulation of semisolids and evaluation by assay
a. Salicyclic acid and benzoic acid ointment
b. Gel formulation Diclofenac gel
7. Cosmetic preparations
a. Lipsticks
b. Cold cream and vanishing cream
c. Clear liquid shampoo
d. Tooth paste and tooth powders.
8. Tablet coating (demonstration)
Scheme of Practical Examination :
Sessionals Annual
Synopsis 05 15
Viva 02 15
Max Marks 20 70
73

Pharm. D - IV YEAR
(17T00401) PHARMACOTHERAPEUTICS – III (THEORY)

Theory:3 Hrs. /Week
1. Scope: This course is designed to impart knowledge and skills necessary for contribution to
quality use of medicines. Chapters dealt cover briefly pathophysiology and mostly therapeutics of
various diseases. This will enable the student to understand the pathophysiology of common
diseases and their management.
2. Objectives: At completion of this subject it is expected that students will be able to understand –
a. the pathophysiology of selected disease states and the rationale for drug therapy;
b. the therapeutic approach to management of these diseases;
c. the controversies in drug therapy;
d. the importance of preparation of individualised therapeutic plans based on diagnosis;
e. needs to identify the patient-specific parameters relevant in initiating drug therapy,
and monitoring therapy (including alternatives, time-course of clinical and laboratory indices
of therapeutic response and adverse effects);
f. describe the pathophysiology of selected disease states and explain the rationale for drug
therapy;
g. to summarize the therapeutic approach to management of these diseases including reference to
the latest available evidence;
h. to discuss the controversies in drug therapy;
i. to discuss the preparation of individualised therapeutic plans based on diagnosis; and
j. identify the patient-specific parameters relevant in initiating drug therapy, and monitoring
therapy (including alternatives, time-course of clinical and laboratory indices of therapeutic
response and adverse effects).
Etiopathogenesis and pharmacotherapy of diseases associated with following systems/ diseases:
Title of the topic
1 Gastrointestinal system: Peptic ulcer disease, Gastro Esophageal Reflux Disease, Inflammatory
bowel disease, Liver disorders - Alcoholic liver disease, Viral hepatitis including jaundice, and
Drug induced liver disorders.
2 Haematological system:Anaemias, Venous thromboembolism, Drug induced blood disorders.
3 Nervous system: Epilepsy, Parkinsonism, Stroke, Alzheimer's disease,
4 Psychiatry disorders: Schizophrenia, Affective disorders, Anxiety disorders, Sleep disorders,
Obsessive Compulsive disorders
5 Pain management including Pain pathways, neuralgias, and headaches.
Evidence Based Medicine
Text Books
a. Clinical Pharmacy and Therapeutics - Roger and Walker, Churchill Livingstone publication
b. Pharmacotherapy: A Pathophysiologic approach - Joseph T. Dipiro et al. Appleton & Lange
Reference Books
a. Pathologic basis of disease - Robins SL, W.B.Saunders publication
b. Pathology and therapeutics for Pharmacists: A Basis for Clinical Pharmacy Practice - Green
and Harris, Chapman and Hall publication
74
c. Clinical Pharmacy and Therapeutics - Eric T. Herfindal, Williams and Wilkins Publication
d. Applied Therapeutics: The clinical Use of Drugs. Lloyd Young and Koda-Kimble
MA
e. Avery’s Drug Treatment, 4th Edn, 1997, Adis International Limited.
f. Relevant review articles from recent medical and pharmaceutical literature.
75

Pharm. D - IV YEAR
(17T00407) PHARMACOTHERAPEUTICS – III (PRACTICAL)

Practical:3 Hrs./Week
Practicals:
Hospital postings for a period of at least 50 hours is required to understand the principles and practice
involved in ward round participation and clinical discussion on selection of drug therapy. Students are
required to maintain a record of 15 cases observed in the ward and the same should be submitted at
the end of the course for evaluation. Each student should present at least two medical cases they have
observed and followed in the wards.
Etiopathogenesis and pharmacotherapy of diseases associated with following systems/ diseases:

Title of the topic
1 Gastrointestinal system: Peptic ulcer disease, Gastro Esophageal Reflux Disease, Inflammatory
bowel disease, Liver disorders - Alcoholic liver disease, Viral hepatitis including jaundice, and
Drug induced liver disorders.
2 Haematological system:Anaemias, Venous thromboembolism, Drug induced blood disorders.
3 Nervous system: Epilepsy, Parkinsonism, Stroke, Alzheimer's disease,
4 Psychiatry disorders: Schizophrenia, Affective disorders, Anxiety disorders, Sleep disorders,
Obsessive Compulsive disorders
5 Pain management including Pain pathways, neuralgias, and headaches.
6 Evidence Based Medicine
Assignments:

1. Minimum & Maximum number of pages
3. Assignment can be a combined presentation at the end of the academic year
4. It shall be computer draft copy

Sessionals Annual
Synopsis 05 15
Viva 02 15
Max Marks 20 70
Note: Total sessional marks is 30 (20 for practical sessional plus 10 marks for regularity,
76

Pharm. D - IV YEAR
(17T00402) HOSPITAL PHARMACY (THEORY)

1. Scope: In the changing scenario of pharmacy practice in India, for successful practice of
Hospital Pharmacy, the students are required to learn various skills like drug distribution, drug
dispensing, manufacturing of parenteral preparations, drug information, patient counselling,
and therapeutic drug monitoring for improved patient care.
2. Objectives: Upon completion of the course, the student shall be able to –

a. know various drug distribution methods;
b. know the professional practice management skills in hospital pharmacies;
c. provide unbiased drug information to the doctors;
d. know the manufacturing practices of various formulations in hospital set up;
e. appreciate the practice based research methods; and
f. appreciate the stores management and inventory control.
Text books: (latest editions)

a. Hospital pharmacy by William .E. Hassan
b. A text book of Hospital Pharmacy by S.H.Merchant&Dr. J.S. Qadry. Revised by
R.K.Goyal& R.K. Parikh
References:
a. WHO consultative group report.
b. R.P.S. Vol.2. Part –B; Pharmacy Practice section.
c. Handbook of pharmacy – health care. Edt. Robin J Harman. The Pharmaceutical press.
Topics
1 Hospital - its Organisation and functions
Hospital pharmacy-Organisation and management
a) Organizational structure-Staff, Infrastructure & work load statistics
b) Management of materials and finance
c) Roles & responsibilities of hospital pharmacist
2 The Budget – Preparation and implementation
Hospital drug policy
a) Pharmacy and Therapeutic committee (PTC)
b) Hospital formulary
c) Hospital committees
- Infection committee
- Research and ethical committee
d) developing therapeutic guidelines
e) Hospital pharmacy communication - Newsletter
3.Hospital pharmacy services

a) Procurement & warehousing of drugs and Pharmaceuticals
b) Inventory control
Definition, various methods of Inventory Control ABC, VED, EOQ, Lead time, safety
stock
c) Drug distribution in the hospital
77
i) Individual prescription method

ii) Floor stock method
iii) Unit dose drug distribution method
d) Distribution of Narcotic and other controlled substances
e) Central sterile supply services – Role of pharmacist
4. Manufacture of Pharmaceutical preparations

a) Sterile formulations – large and small volume parenterals
b) Manufacture of Ointments, Liquids, and creams
c) Manufacturing of Tablets, granules, capsules, and powders
d) Total parenteral nutrition
5 Continuing professional development programs

Education and training
Radio Pharmaceuticals – Handling and packaging
Professional Relations and practices of hospital pharmacist
78

Pharm. D - IV YEAR
(17T00408) HOSPITAL PHARMACY (PRACTICAL)
1. Assessment of drug interactions in the given prescriptions

2. Manufacture of parenteral formulations, powders.
3. Drug information queries.
4. Inventory control
List of Assignments:
1. Design and Management of Hospital pharmacy department for a 300 bedded hospital.
2. Pharmacy and Therapeutics committee – Organization, functions, and limitations.
3. Development of a hospital formulary for 300 bedded teaching hospital
4. Preparation of ABC analysis of drugs sold in one month from the pharmacy.
5. Different phases of clinical trials with elements to be evaluated.
6. Various sources of drug information and systematic approach to provide unbiased drug
information.
7. Evaluation of prescriptions generated in hospital for drug interactions and find out the suitable
management.
Special requirements:
1. Each college should sign MoU with nearby local hospital having minimum 150 beds for
providing necessary training to the students’ on hospital pharmacy activities.
2. Well equipped with various resources of drug information.
Sessionals Annual
Synopsis 05 15
Viva 02 15
Max Marks 20 70
79

Pharm. D - IV YEAR
(17T00403) CLINICAL PHARMACY (THEORY)
1. Objectives of the Subject :

Upon completion of the subject student shall be able to (Know, do, appreciate) –
a. monitor drug therapy of patient through medication chart review and clinical review;
b. obtain medication history interview and counsel the patients;
c. identify and resolve drug related problems;
d. detect, assess and monitor adverse drug reaction;
e. interpret selected laboratory results (as monitoring parameters in therapeutics) of specific

disease states; and
f. retrieve, analyse, interpret and formulate drug or medicine information.
Text books (Theory)

a. Practice Standards and Definitions - The Society of Hospital Pharmacists of Australia.
b. Basic skills in interpreting laboratory data - Scott LT, American Society of Health
System Pharmacists Inc.
c. Biopharmaceutics and Applied Pharmacokinetics - Leon Shargel, Prentice Hall
publication.
d. A text book of Clinical Pharmacy Practice; Essential concepts and skills,
Dr.G.Parthasarathietal, Orient OrientLangramPvt.Ltd. ISSBN8125026
References
a. Australian drug information -Procedure manual. The Society of Hospital Pharmacists of
Australia.
b. Clinical Pharmacokinetics - Rowland and Tozer, Williams and Wilkins Publication.
c. Pharmaceutical statistics. Practical and clinical applications. Sanford Bolton, Marcel
Dekker, Inc.

Title of the topic
1. Definitions, development and scope of clinical pharmacy
Introduction to daily activities of a clinical pharmacist
a. Drug therapy monitoring (medication chart review, clinical review, pharmacist
interventions)
b. Ward round participation
c. Adverse drug reaction management
d. Drug information and poisons information
e. Medication history
f. Patient counseling
g. Drug utilisation evaluation (DUE) and review (DUR)
h. Quality assurance of clinical pharmacy services
Patient data analysis
80
The patient's case history, its structure and use in evaluation of drug therapy & Understanding
common medical abbreviations and terminologies used in clinical practices.
2. Clinical laboratory tests used in the evaluation of disease states, and interpretation of
test results
a. Haematological, Liver function, Renal function, thyroid function tests
b. Tests associated with cardiac disorders
c. Fluid and electrolyte balance
d. Microbiological culture sensitivity tests
e. Pulmonary Function Tests
3. Drug & Poison information

a. Introduction to drug information resources available
b. Systematic approach in answering DI queries
c. Critical evaluation of drug information and literature
d. Preparation of written and verbal reports
e. Establishing a Drug Information Centre
f. Poisons information- organization & information resources
4. Pharmacovigilance
a. Scope, definition and aims of pharmacovigilance
b. Adverse drug reactions - Classification, mechanism, predisposing factors, causality
assessment [different scales used]
c. Reporting, evaluation, monitoring, preventing & management of ADRs
d. Role of pharmacist in management of ADR.
5. Communication skills, including patient counselling techniques, medication history

interview, presentation of cases.
Pharmaceutical care concepts
Critical evaluation of biomedical literature
Medication errors
81

Pharm. D - IV YEAR
(17T00409) CLINICAL PHARMACY (PRACTICAL)
Students are expected to perform 15 practicals in the following areas covering the topics dealt in
theory class.
a. Answering drug information questions (4 Nos)

b. Patient medication counselling (4 Nos)
c. Case studies related to laboratory investigations (4 Nos)
d. Patient medication history interview (3 Nos)
Assignment:
Students are expected to submit THREE written assignments (1500 – 2000 words) on the topics
given to them covering the following areas dealt in theory class.
Drug information, Patient medication history interview, Patient medication counselling, Critical
appraisal of recently published articles in the biomedical literature which deals with a drug or
therapeutic issue.

6. Time allocated for presentation may be 8+2 Min
82

Pharm. D - IV YEAR
(17T00404) BIOSTATISTICS AND RESEARCH METHODOLOGY (THEORY)
1. Detailed syllabus and lecture wise schedule

Research Methodology
a) Types of clinical study designs:
Case studies, observational studies, interventional studies,
b) Designing the methodology
c) Sample size determination and Power of a study
Determination of sample size for simple comparative experiments,
determination of sample size to obtain a confidence interval of specified width,
power of a study
d) Report writing and presentation of data
2. Biostatistics
2.1 a) Introduction
b) Types of data distribution
c) Measures describing the central tendency distributions- average, median, mode
d) Measurement of the spread of data-range, variation of mean, standard deviation, variance,
coefficient of variation, standard error of mean.
2.2 Data graphics

Construction and labeling of graphs, histogram, piecharts, scatter plots, semi logarthimic plots
3. Basics of testing hypothesis

a) Null hypothesis, level of significance, power of test, P value, statistical estimation of
confidence intervals.
b) Level of significance (Parametric data)- students t test (paired and unpaired), chi Square
test, Analysis of Variance (one-way and two-way)
c) Level of significance (Non-parametric data)- Sign test, Wilcoxan’s signed rank test,
Wilcoxan rank sum test, Mann Whitney U test, Kruskal-Wall is test (one way ANOVA)
d) Linear regression and correlation- Introduction, Pearsonn’s and Spearmann’s correlation
and correlation co-efficient.
e) Introduction to statistical software: SPSS, Epi Info, SAS.
4. Statistical methods in epidemiology

Incidence and prevalence, relative risk, attributable risk
5. Computer applications in pharmacy

Computer System in Hospital Pharmacy: Patterns of Computer use in Hospital Pharmacy –
Patient record database management, Medication order entry – Drug
labels and list – Intravenous solution and admixture, patient medication profiles, Inventory
control, Management report & Statistics.
Computer In Community Pharmacy
Computerizing the Prescription Dispensing process
83
Use of Computers for Pharmaceutical Care in community pharmacy Accounting and General
ledger system
Drug Information Retrieval & Storage:
Introduction – Advantages of Computerized Literature Retrieval
Use of Computerized Retrieval
Reference books:
a. Pharmaceutical statistics- practical and clinical applications, Sanford Bolton 3rd edition,
publisher Marcel Dekker Inc. NewYork.
b. Drug Information- A Guide for Pharmacists, Patrick M Malone, Karen L Kier, John E
Stanovich , 3rd edition, McGraw Hill Publications 2006
84

Pharm. D - IV YEAR
(17T00405) BIOPHARMACEUTICS AND PHARMACOKINETICS (THEORY)
1. Biopharmaceutics
1. Introduction to Biopharmaceutics
a. Absorption of drugs from gastrointestinal tract.
b. Drug Distribution.
c. Drug Elimination.
2. Pharmacokinetics
2. Introduction to Pharmacokinetics.
a. Mathematical model
b. Drug levels in blood.
c. Pharmacokinetic model
d. Compartment models
e. Pharmacokinetic study.
3. One compartment open model.
a. Intravenous Injection (Bolus)
b. Intravenous infusion.
Multicompartment models.
a. Two compartment open model.
b. IV bolus, IV infusion and oral administration
4. Multiple – Dosage Regimens.
a. Repititive Intravenous injections – One Compartment Open Model
b. Repititive Extravascular dosing – One Compartment Open model
c. Multiple Dose Regimen – Two Compartment Open Model
Nonlinear Pharmacokinetics.
a. Introduction
b. Factors causing Non-linearity.
c. Michaelis- menton method of estimating parameters.
5. Noncompartmental Pharmacokinetics.
a. Statistical Moment Theory.
b. MRT for various compartment models.
c. Physiological Pharmacokinetic model.
Bioavailability and Bioequivalence.

a. Introduction.
b. Bioavailability study protocol.
c. Methods of Assessment of Bioavailability
85

Pharm. D - IV YEAR
(17T00410) BIOPHARMACEUTICS AND PHARMACOKINETICS (PRACTICAL)
1. Improvement of dissolution characteristics of slightly soluble drugs by some methods.

2. Comparison of dissolution studies of two different marketed prod ucts of same drug.
3. Influence of polymorphism on solubility and dissolution.
4. Protein binding studies of a highly protein bound drug and poorly protein bound drug.
5. Extent of plasma-protein binding studies on the same drug (i.e. highly and poorly
protein bound drug) at different concentrations in respect of constant time.
6. Bioavailability studies of some commonly used drugs on animal/human model.
7. Calculation of Ka, Ke, t1/2, Cmax, AUC, AUMC, MRT etc. from blood profile data.
8. Calculation of bioavailability from urinary excretion data for two drugs.
9. Calculation of AUC and bioequivalence from the given data for two drugs.
10. In vitro absorption studies.
11. Bioequivalency studies on the different drugs marketed.(eg) Tetracycline,
Sulphamethoxzole, Trimethoprim, Aspirin etc., on animals and human volunteers.
12. Absorption studies in animal inverted intestine using various drugs.
13. Effect on contact time on the plasma protein binding of drugs.
14. Studying metabolic pathways for different drugs based on elimination kinetics data.
15. Calculation of elimination half- life for different drugs by using urinary elimination data
and blood level data.
16. Determination of renal clearance.
References:
a. Biopharmaceutics and C linical Pharmacokinetics by, Milo Gibaldi
b. Remington’s Pharmaceutical Sciences, By Mack Publishing Company, Pennsylvnia.
c. Pharmacokinetics: By Milo Glbaldi Donald, R. Mercel Dekker Inc.
d. Hand Book of Clinical Pharmacokinetics, By Milo Gibaldi and Laurie Prescott by ADIS
Health Science Press.
e. Biopharmaceutics and Pharmacokinetics; By Robert F Notari
f. Biopharmaceutics; By Swarbrick
g. Bio pharmaceutics and Pharmacokinetics-A Treatise, By D. M. Brahmankar and Sunil
B.Jaiswal, VallabhPrakashanPitampura, Delhi
h. Cilincal Pharmacokinetics, Concepts and Applications: By Malcolm Rowland and
Thomas, N. Tozen, Lea and Febrger, Philadelphia, 1995.
i. Dissolution, Bioavailability and Bioequivalence, By Abdou H.M, Mack, Publishing

Company, Pennsylvania 1989.
j. Biopharmaceutics and Clinical Pharmacokinetics-An introduction 4t h edition Revised
and expanded by Rebort F Notari Marcel Dekker Inn, New York and Basel, 1987.
k. Encyclopedia of Pharmaceutical Technology, Vol 13, James Swarbrick, James, C.
Roylan, Marcel Dekker Inc, New York 1996.
86

Pharm. D - IV YEAR
(17T00406) CLINICAL TOXICOLOGY (THEORY)

1. General principles involved in the management of poisoning

Antidotes and the clinical applications.
Supportive care in clinical Toxicology.
Gut Decontamination.
Elimination Enhancement.
Toxicokinetics.
2. Clinical symptoms and management of acute poisoning with the following agents –
a) Pesticide poisoning: organophosphorous compounds, carbamates, organochlorines,
pyrethroids.
b) Opiates overdose.
c) Antidepressants
d) Barbiturates and benzodiazepines.
e) Alcohol: ethanol, methanol.
f) Paracetamol and salicylates.
g) Non-steroidal antiinflammatory drugs.
h) Hydrocarbons: Petroleum products and PEG.
i) Caustics: inorganic acids and alkali.
j) Radiation poisoning
3. Clinical symptoms and management of chronic poisoning with the following agents – Heavy
metals: Arsenic, lead, mercury, iron, copper
Venomous snake bites: Families of venomous snakes, clinical effects of venoms, general
management as first aid, early manifestations, complications and snake bite injuries.
4. Plants poisoning. Mushrooms, Mycotoxins.
Food poisonings
. Envenomations – Arthropod bites and stings.
5. Substance abuse:
Signs and symptoms of substance abuse and treatment of dependence
a) CNS stimulants: amphetamine
b) Opioids
c) CNS depressants
d) Hallucinogens: LSD
e) Cannabis group
f) Tobacco
References:
a. Matthew J Ellenhorn. ELLENHORNS MEDICAL TOXICOLOGY – DIAGNOSIS AND
TREATMENT OF POISONING. Second edition. Williams and Willkins publication, London
b. V VPillay. HANDBOOK OF FORENSIC MEDICINE AND TOXICOLOGY. Thirteenth
edition 2003 Paras Publication, Hyderabad
87

Pharm. D - IV YEAR
(17T00411) PHARMACOTHERAPEUTICS I & II (THEORY)
Theory: 3Hrs/week
Etiopathogenesis and pharmacotherapy of diseases associated with following
systems/ diseases.
1. 13 hrs
Cardiovascular system: Hypertension, Congestive cardiac failure, Angina Pectoris,
Myocardial infarction, Hyperlipidaemias, Electrophysiology of heart and
Arrhythmias
2. 14 hrs
Respiratory system: Introduction to Pulmonary function test, Asthma, Chronic
obstructive airways disease, Drug induced pulmonary diseases
Endocrine system: Diabetes, Thyroid diseases, Oral contraceptives, Hormone
replacement therapy, Osteoporosis
3. 13 hrs
General prescribing guidelines for
a. Paediatric patients
b. Geriatric patients
c. Pregnancy and breast feeding
Ophthalmology: Glaucoma, Conjunctivitis- viral & bacterial
Introduction to rational drug use Definition, Role of pharmacist Essential drug
concept Rational drug formulations
Dermatology: Psoriasis, Scabies, Eczema, Impetigo.
4. 18 hrs
Infectious disease: Guidelines for the rational use of antibiotics and surgical
Prophylaxis, Tuberculosis, Meningitis, Respiratory tract infections, Gastroenteritis,
Endocarditis, Septicemia, Urinary tract infections, Protozoal infection- Malaria,
HIV & Opportunistic infections, Fungal infections, Viral infections, Gonarrhoea and
Syphillis
5. 17hrs
Musculoskeletal disorders : Rheumatoid arthritis, Osteoarthritis, Gout, Spondylitis,
Systemic lupus erythematosus.
Renal system: Acute Renal Failure, Chronic Renal Failure, Renal Dialysis, Drug
induced renal disorders
Oncology: Basic principles of Cancer therapy, General introduction to cancer
chemotherapeutic agents, Chemotherapy of breast cancer, leukemia. Management of
chemotherapy nausea and emesis
88

Pharm. D - IV YEAR
(17T00412) PHARMACOTHERAPEUTICS – I & II (PRACTICAL)
Practicals: 3 Hrs./Week
Practicals:
Hospital postings in various departments designed to complement the lectures by
providing practical clinical discussion; attending ward rounds; follow up the progress and
changes made in drug therapy in allotted patients; case presentation upon discharge.
Students are required to maintain a record of cases presented and the same should be
submitted at the end of the course for evaluation. A minimum of 20 cases should be
presented and recorded covering most common diseases.
Assignments:
Students are required to submit written assignments on the topics given to them. Topics
allotted should cover recent developments in drug therapy of various diseases. A
minimum of THREE assignments [1500 – 2000 words] should be submitted for
evaluation.
Sessionals Annual
Synopsis 05 15
Viva 02 15
Max Marks 20 70
Duration 03 hrs 04 hrs
Note: Total sessional marks is 30 (20 for practical sessional plus 10 marksfor regularity,
89

Pharm. D - V YEAR
(17T00501) CLINICAL RESEARCH (THEORY)

Theory:3 Hrs. /Week
1. Drug development process:
Introduction
Various Approaches to drug discovery
1. Pharmacological
2. Toxicological
3. IND Application
4. Drug characterization
5. Dosage form
2. Clinical development of drug:
1. Introduction to Clinical trials
2. Various phases of clinical trial.
3. Methods of post marketing surveillance
4. Abbreviated New Drug Application submission.
3.
1. Good Clinical Practice – ICH, GCP, Central drug standard control organisation (CDSCO)
guidelines
2. Challenges in the implementation of guidelines
3. Ethical guidelines in Clinical Research
4. Composition, responsibilities, procedures of IRB / IEC
4.
1. Overview of regulatory environment in USA, Europe and India.
2. Role and responsibilities of clinical trial personnel as per ICH GCP
a. Sponsor
b. Investigators
c. Clinical research associate
d. Auditors
e. Contract research coordinators
f. Regulatory authority
5.
1. Designing of clinical study documents (protocol, CRF, ICF, PIC with assignment)
2. Informed consent Process
3. Data management and its components
4. Safety monitoring in clinical trials.
References:
a. Central Drugs Standard Control Organization. Good Clinical Practices-Guidelines for Clinical
Trials on Pharmaceutical Products in India. New Delhi: Ministry of Health; 2001.
b. International Conference on Harmonisation of Technical requirements for registration of
Pharmaceuticals for human use. ICH Harmonised Tripartite Guideline. Guideline for Good
Clinical Practice.E6; May 1996.
c. Ethical Guidelines for Biomedical Research on Human Subjects 2000. Indian Council of
Medical Research, New Delhi.
90
d. Textbook of Clinical Trials edited by David Machin, Simon Day and Sylvan Green, March
2005, John Wiley and Sons.
e. Principles of Clinical Research edited by Giovanna di Ignazio, Di Giovanna and Haynes.
f. Clinical Data Management edited by R K Rondels, S A Varley, C F Webbs. Second Edition,
Jan 2000, Wiley Publications.
g. Goodman & Gilman: JG Hardman, LE Limbard, 10th Edn. McGraw Hill Publications,2001.
91

Pharm. D - V YEAR
(17T00502) PHARMACOEPIDEMIOLOGY AND PHARMACOECONOMICS (THEORY)

1. Pharmacoepidemiology:
Definition and scope:
Origin and evaluation of pharmacoepidemiology need for pharmacoepidemiology, aims and
applications.
Measurement of outcomes in pharmacoepidemiology
Outcome measure and drug use measures
Prevalence, incidence and incidence rate. Monetary units, number of prescriptions, units of drugs
dispensed, defined daily doses and prescribed daily doses, medication adherence measurement
2. Concept of risk in pharmacoepidemiology
Measurement of risk, attributable risk and relative risk, time-risk relationship and odds ratio
Pharmacoepidemiological methods
Includes theoretical aspects of various methods and practical study of various methods with the help
of case studies for individual methods
Drug utilization review, case reports, case series, surveys of drug use, cross –
sectional studies, cohort studies, case control studies, case –cohort studies, meta – analysis studies,
spontaneous reporting, prescription event monitoring and record linkage system.
3. Sources of data for pharmacoepidemiological studies
Ad Hoc data sources and automated data systems.
Selected special applications of pharmacoepidemiology
Studies of vaccine safety, hospital pharmacoepidemiology, pharmacoepidemiology and risk
management, drug induced birth defects.
4. Phrmacoeconomics:
Definition, history, needs of pharmacoeconomic evaluations
Role in formulary management decisions
Pharmacoeconomic evaluation
Outcome assessment and types of evaluation
Includes theoretical aspects of various methods and practical study of various
methods with the help of case studies for individual methods: Cost – minimization, cost- benefit, cost
– effectiveness, cost utility
5. Applications of Pharmacoeconomics
Software and case studies
92


Pharm. D - V YEAR
(17T00503) CLINICAL PHARMACOKINETICS AND PHARMACOTHERAPEUTIC DRUG

MONITORING (THEORY)
1. Introduction to Clinical pharmacokinetics.
Design of dosage regimens:
Nomograms and Tabulations in designing dosage regimen, Conversion from intravenous to oral
dosing, Determination of dose and dosing intervals, Drug dosing in the elderly and pediatrics and
obese patients.
2. Pharmacokinetics of Drug Interaction:
a. Pharmacokinetic drug interactions
b. Inhibition and Induction of Drug metabolism
c. Inhibition of Biliary Excretion.
3. Therapeutic Drug monitoring:
a. Introduction
b. Individualization of drug dosage regimen (Variability – Genetic, Age and Weight , disease,
Interacting drugs).
c. Indications for TDM. Protocol for TDM.
d. Pharmacokinetic/Pharmacodynamic Correlation in drug therapy.
e. TDM of drugs used in the following disease conditions: cardiovascular disease, Seizure disorders,
Psychiatric conditions, and Organ transplantations.
4. Dosage adjustment in Renal and hepatic Disease.
a. Renal impairment
b. Pharmacokinetic considerations
c. General approach for dosage adjustment in Renal disease.
d. Measurement of Glomerular Filtration rate and creatinine clearance.
e. Dosage adjustment for uremic patients.
f. Extracorporeal removal of drugs.
g. Effect of Hepatic disease on pharmacokinetics.
5. Population Pharmacokinetics.
a. Introduction to Bayesian Theory.
b. Adaptive method or Dosing with feed back.
c. Analysis of Population pharmacokinetic Data.
Pharmacogenetics
a. Genetic polymorphism in Drug metabolism: Cytochrome P-450 Isoenzymes.
b. Genetic Polymorphism in Drug Transport and Drug Targets.
c. Pharmacogenetics and Pharmacokinetics/Pharmacodynamic considerations
93

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ACADEMIC REGULATIONS COURSE

PHARM D. (REGULAR SIX YEAR COURSE)

(APPICABLE FOR THE BATCHES ADMITED

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Doctor of Pharmacy (Pharm.D) Syllabus

1. Award of Pharm. D Degree

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3. Minimum qualification for admission to. –

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(1) (2) (3) (4) (5) (6) (7) (8)

1.1 17T00101 1 3 1.7 17T00107

1.3 17T00103 Medicinal Biochemistry 3 1 3 1.9 17T00109

1.4 17T00104 1 3 2.0 17T00110

Total hours 16 6 = (40) 18

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2.1 17T00201 Pathophysiology 3 1 - - -

2.3 17T00203 Pharmacognosy 3 1 3  2.8 17T00208

2.4 17T00204 Pharmacology-I 3 1 - - -

3.1 17T00301 Pharmacology-II 3 1 3  3.7 17T00307

3.3 17T00303 Pharmacotherapeutics-II 3 1 3  3.9 17T00309

3.4 17T00304 Pharmaceutical Jurisprudence 2 - - - -

3.5 17T00305 Medicinal Chemistry 3 1 3  4.0 17T00310

4.1 17T00401 Pharmacotherapeutics-III 3 1 3  4.7 17T00407

4.2 17T00402 Hospital Pharmacy 2 1 3  4.8 17T00408

4.3 17T00403 Clinical Pharmacy 3 1 3  4.9 17T00409

4.4 17T00404 Biostatistics & Research 2 1 - - -

4.6 17T00406 Clinical Toxicology 2 1 - - -

4.11 14T00411 Pharmacotherapeutics I 3 1 3  4.12 14T00412

S.N Subjects Name of Subject No. of hours No. of No. of

(1) (2) (3) (4) (5) (6)

5.1 17T00501 Clinical Research 3 1 -

5.3 17T00503 Clinical Pharmacokinetics & 2 1 -

(i) Six months in General Medicine department, and

Second Year examination:

600 300 = 900

7. Attendance requirements: (Eligibility for appearing Examination) - Only such

9. Award of sessional marks and maintenance of records.―

17. Methodology.― To complete the project work following methodology shall be

JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY ANANTAPUR

i) to provide patient care in cooperation with patients, prescribers, and other

iii) to promote health improvement, wellness, and disease prevention in co-

iv) to demonstrate skills in monitoring of the National Health Programmes and

v) to develop leadership qualities to function effectively as a member of the

vi) to communicate effectively with patients and the community.

i) All parts of the internship shall be done, as far as possible, in institutions in

compulsory rotational internship to the satisfaction of the College authorities

ii) Satisfactory completion of internship shall be determined on the basis of the

(1) Proficiency of knowledge required for each case management SCORE 0-

(2) The competency in skills expected for providing Clinical

(3) Responsibility, punctuality, work up of case, involvement

(4) Ability to work in a team (Behavior with other healthcare professionals

(5) Initiative, participation in discussions, research aptitude. SCORE 0-

3) Every candidate shall be required, after passing the final Pharm.D. or

21. Transitory regulations:

22. With – holding of results:

24. RULES FOR DISCIPLINARY ACTION FOR MALPRACTICE / IMPROPER

consecutive semesters from class work and