Energy Essentials & Superfoods

Energy Essentials & Superfoods – The Energy Blueprint Store 29/11/21, 15:37
HOME PRODUCTS CONTACT 1

!!
$119.00
MY ACCOUNT
Use Coupon Code THANKS2021!

for 25% OFF All Supplements. Or
Get 35% OFF when you Subscribe
& Save.
ENERGY ESSENTIALS
& SUPERFOODS
THE MOST
ADVANCED AND
COMPREHENSIVE
MULTIVITAMIN/M
ULTIMINERAL/SU
PERFOODS
BLEND ON THE
MARKET.
BUY NOW!
https://store.theenergyblueprint.com/products/energy-essentials-superfoods/ Página 1 de 92
NEW BATCH ARRIVING IN A FEW DAYS AND

WILL SHIP OUT NEXT WEEK
ARE YOUR FATIGUE ISSUES CAUSED BY

NUTRITIONAL DEFICIENCIES? IT'S LIKELY
AT LEAST A PARTIAL CONTRIBUTOR!
Did you know that your body REQUIRES over 30 di!erent

vitamins and minerals and that almost EVERYONE is
deficient in at least a few of those compounds?
SO WHAT DO YOU NEED TO DO?

Simple: Plug the holes in your diet and provide your body with the nutrients and
cofactors it needs for optimal health, disease prevention, and energy production. That
is exactly what Energy Essentials & Superfoods is designed to do. This is your way to
eliminate your deficiencies and virtually guarantee your body has everything it needs
to function optimally — every single day, in just 30 seconds.
INTRODUCING
ENERGY
ESSENTIALS &
SUPERFOODS
With 45 bioavailable ingredients and 36
scientifically proven health benefits, it’s
the most advanced and comprehensive
multivitamin/multimineral/superfood
blend on the market
BUY NOW!
BACK TO THE PROBLEM...

In the U.S., 9 out of 10 adults do not meet the recommended daily allowances (RDAs)
for Vitamin D and Vitamin E, and over 50% of people don’t meet the RDAs for vitamin A,
calcium and magnesium. And that’s just to name a few of many important compounds
that many people are deficient in! As you can see from this graph, it’s almost
guaranteed that you have at least a couple nutrient deficiencies, if not numerous of
them. According to the USDA, over 92% of people have deficiencies in essential
micronutrients needed to maintain basic health. This is the single most widespread
risk factor for chronic disease.
THERE ARE 3 MAJOR REASONS WHY

PEOPLE AREN'T GETTING ENOUGH...
1. Non-optimal food choices. The most common and most obvious cause of
deficiencies is that the majority of people are making very poor food choices —
eating a highly processed, unhealthy diet that’s heavy in fats, sugars, and
chemicals and light in essential nutrients.
2. Poor gut health, stress, alcohol, medications and health issues. Due to poor gut
health and microbiome imbalances, many people have absorption problems. So,
they can’t even extract the nutrients from their food properly. Plus, many people
have chronic stress, chronic infections and chronic medical conditions that
rapidly deplete levels of critical vitamins and minerals. Stress alone has been
known to deplete vitamins B1, B2, B3, B5, B6, B7, B9, B12, vitamin A, vitamin C,
vitamin D, magnesium, chromium, copper, iodine, potassium, selenium, zinc,
and more.
3. Lower vitamin/mineral content in fruits and veggies. On top of that, our soils
have become so degraded from decades of modern Big Agriculture farming
methods that the mineral and vitamin content in fruits and vegetables has
dropped dramatically.
See, 70 years ago we could get most of our vitamins and minerals from eating small
amounts of produce.
Today, that’s just not possible.
Even if you’re eating a much be"er diet than the Standard American Diet, the fact is
even those eating healthfully have nutritional deficiencies or suboptimal intakes of
many of these key nutrients.
Across the board, people’s bodies have been slowly stripped of the vital compounds
they need to thrive.
And it’s absolutely hurting our health and energy levels in a massive way.
GET YOUR ENERGY

ESSENTIALS & SUPERFOODS
NOW!
1 M O N T H S U P P LY 2 M O N T H S U P P LY
ENERGY ENERGY
ESSENTIALS & ESSENTIALS &
SUPERFOODS SUPERFOODS
$100.00 $179.00
" ADD TO CART " ADD TO CART

Worldwide Shipping (FREE Shipping within the U.S.)*

* For international orders: All shipments are shipped Duties, Customs, & Taxes unpaid.
Buyer is responsible for delivery fees.
ENERGY ESSENTIALS & SUPERFOODS

INGREDIENTS
Vitamin A refers to a group of fat-
VITAMIN A COMPLEX
soluble retinoids and carotenoids, the
main dietary ones being retinol and
beta-carotene. Only retinol has
biological activity within the body and
can be considered “true” vitamin A.
Beta-carotene can be converted by

the body into vitamin A, but due to
genetic di#erences, some people do
this very poorly, so we’ve included
retinol in its bioactive form in addition
to beta-carotene.
Retinol is involved in regulating the

growth and specialization of nearly
every cell in the human body. In adults,
it is critical for vision and immune
function, with insu#icient intakes
leading to worsening eyesight
(particularly at night) and a greater
risk of infections and autoimmunity.1–3
We have the ability to make retinol
from beta-carotene and a couple other
carotenoids, which is why these
precursors are considered a source of
vitamin A. The problem is that the
e#iciency of the conversion process
varies widely between individuals and
populations due to genetic
variations.4 The bioavailability of beta-
carotene is also highly variable,
depending on factors such as the food
matrix, food preparation method, and
one’s digestive and absorptive
capacities.5 As such, beta-carotene is
not a reliable source of vitamin A and
we have provided most of one’s daily

vitamin A requirement in the form of
retinol.
The B-complex vitamins include 8

B-COMPLEX VITAMINS
di#erent vitamins that are critical for
methylation and energy production.
Without them, we wouldn’t be able to
turn the food we eat into cellular
energy, our mitochondria couldn’t
function, and we wouldn’t be able to
turn the expression of certain genes
on or o# depending on our body’s
needs.
Thiamine (B1) is required to

harvest energy from glucose, for
the synthesis of energy-
carrying molecules within
mitochondria, and for nerve
conduction.
Riboflavin (B2) is the central
unit for flavoproteins, which are
necessary for mitochondrial
energy production, antioxidant
reactions and glutathione
recycling, neurotransmi"er
regulation, and the metabolism
of niacin, vitamin B6, and folate.
Niacin (B3) is the central unit for

NAD+ and NADP, which are
required central to energy
production, antioxidant
reactions, detoxification, folate
metabolism, the repair and
regeneration of DNA and
proteins, and the biosynthesis
of fa"y acids, cholesterol, and
steroid hormones.
Pantothenic acid (B5) is the
central unit of coenzyme A,
which plays a vital role in energy
production and the metabolism
of many nutrients, such as the
breakdown of fats,
carbohydrates, and proteins,
the synthesis of fa"y acids,
ketones, cholesterol, steroid
hormones, and
neurotransmi"ers, genetic
expression, and detoxification.
Pyridoxal (B6) is required for
amino acid metabolism, gene
expression, and the breakdown
of homocysteine.
Biotin (B7) is the central
component of several enzymes
involved in energy production,
amino acid metabolism, gene

expression, and cell growth.
Folate (B9) is required for
methylation throughout our
cells and mitochondria, DNA
synthesis, cell division, the
metabolism of glycine, and the
breakdown of homocysteine.
Cobalamin (B12) is necessary
for just two important reactions
in the body: (1) the breakdown
of homocysteine alongside
folate and, by virtue of this
reaction, the recycling of folate,
and (2) the breakdown of
certain amino acids and fa"y
acids.
While all B-vitamin jobs are important,

methylation and the breakdown of
homocysteine are the ones that many
people struggle with because of
inadequate B-vitamin intakes and
genetic mutations. Inappropriate
methylation plays a role in many
diseases, including
cancer,6,7 neurodegeneration,8,9, and
mood disorders like depression.10,11
Elevated levels of homocysteine is a
major risk factor for cardiovascular

diseases by directly causing blood
vessel damage, reducing the flexibility
of blood vessels, and altering
processes involved in regulating blood
fluidity.12 Additionally, high levels of
homocysteine are strongly implicated
in vascular dementia and impaired
cognitive function for several
reasons:13–16
Neurotoxic
Increases oxidative stress and
inflammation
Related to brain lesions and
shrinkage
Interferes with roper protein
synthesis
Ensuring ample B-vitamin intake and

status is a fundamental aspect of
optimal health
Benfotiamine is a special fat-soluble

BENFOTIAMINE
form of thiamin that is capable of
easily passing through cell
membranes and providing free
thiamine directly to the cell,
particularly red blood cells and liver
17
cells.17 Bioavailability studies have

shown that benfotiamine increases
serum thiamine concentrations 5- to
10-fold more than other forms of
thiamine.18,19
Benfotiamine works to protect the

body in several key ways:
Activates an enzyme
(transketolase) that reduces
the creation of advanced
glycation endproducts (AGEs)
and protects against oxidative
stress.25,26
Increases cell survival and
regeneration.27–29
Reduces inflammation.30,31
Improves brain health.32
Through these mechanisms, research

has shown benfotiamine and thiamine
supplementation to have notable
health benefits, especially in those
with diabetes:
In healthy smokers, 1050 mg/d

of benfotiamine was able to cut
the smoking-induced
impairment of endothelial
function in half.33
In type 2 diabetes, 1050 mg/d

was able to completely prevent
the 35% decline in blood vessel
function after eating a meal rich
in glycation
endproducts.34<.sup>
In type 2 diabetes, 150 mg/d of
thiamine for 1 month was able to
significantly reduce fasting
glucose concentrations and
improve leptin sensitivity.35
Several studies have shown
200–600 mg/d of benfotiamine
to improve diabetic
neuropathy.36–39
In adults with osteoarthritis,
just 50 mg/d was able to reduce
AGE concentrations, reduce
pain, and improve physical
function.40
In Alzheimer’s disease, 300
mg/d for 18 months was able to
improve cognitive function.41
Riboflavin is critical for numerous

RIBOFLAVIN 5'
functions in the body, but its most
PHOSPHATE
important role for most people is
ensuring the proper function of the
methylenetetrahydrofolate reductase
(MTHFR) enzyme, which is necessary
to recycle folate and detoxify
homocysteine. A significant number of
people have a mutation in MTHFR (the
677C→T variant) that reduces this
enzymes activity, making them slow to
convert 5,10-methylene-THF to 5-
methyl-THF, the primary circulatory
form of folate utilized in homocysteine
detoxification.42
The mutation makes it more di#icult

for MTHFR to bind to a riboflavin-
containing molecule (FAD) that is
required for it to function.43,44
Supplementing riboflavin and
saturating riboflavin stores in the body
overcomes this reduced binding ability
by having more FAD available to bind
to, making the enzyme function
normally again.
In other words, this mutation only

causes a problem when riboflavin
intake is inadequate. When you divide
up people based on their riboflavin
status, only those who are deficient in
riboflavin have elevated homocysteine
even in the presence of the MTHFR
45
polymorphism.45
Although the dietary reference intake

is set at 1–2 mg/d for healthy adults,
this amount is not su#icient to
saturate riboflavin stores for most
people, particularly those with chronic
inflammation that reduces riboflavin
absorption.46
A meta-analysis of 14 studies found

that supplementing with 2–5 mg/d
above-and-beyond this reference
intake leads to improved riboflavin
status.47 Moreover, supplementing
with just 2 mg/d has been shown to
drop homocysteine by 40% in those
with the MTHFR polymorphism.48
It’s also worth noting that riboflavin

can lower blood pressure in those with
the MTHFR polymorphism,49 which
may be secondary to reducing
homocysteine. Several interventions
have noted significant reductions in
blood pressure (5–10 mmHg) with less
than 2 mg/d of riboflavin
supplementation.50–52
Niacinamide is a direct precurser to

NIACINAMIDE
NAD+, which is involved in numerous
notable health benefits like protecting
against neurodegeneration,
enhancing insulin sensitivity,
increasing mitochondrial biogenesis,
and sirtuin functions involved in
“healthy aging”. 55,57
Pantesin (pantethine) is a form of

PANTESIN
pantothenic acid that not only
satisfies our requirements but also
has unique blood lipid–towering
properties. A 2005 review of 28 small
clinical trials with 64 participants with
dyslipidemia reported a and 4 month
reductions in LDL-C of 10% and 20%
triglycerides of 14% and 33 % and
increase in HDL-C of 6% and 8%
respectively.58
Pyridoxal 5’ Phosphate (P5P) is the

PYRIDOXAL 5'
only biologically active form of vitamin
PHOSPHATE
B6, playing a vital role in the function
of over 100 enzymes that catalyze
essential chemical reactions in the
human body. Adequate B6 is essential
for various aspects of protein
metabolism, the synthesis of
glutathione from homocysteine via the
transsulfuration pathway, and the
metabolism of folate.
Biotin (also known as vitamin H) is a

BIOTIN
key factor in helping our body convert
food into energy. Biotin is also critical
for hair, skin, and nail health.
A notable percentage of the

FOLATE
population harbors variants in the
methylenetetrahydrofolate reductase
(MTHFR) enzyme, which is necessary
to recycle folate and detoxify
homocysteine. These variants reduce
the ability of the MTHFR enzyme to
turn 5,10-methylenetetrahydrofolate
(5,10-methylene THF) into 5-methyl
THF, which is the form required to
recycle homocysteine.
Supplementing metafolin (5-methyl

THF), bypasses this issue entirely,
providing bioavailable folate for the
body to use regardless of
polymorphisms.
Trimethylglycine (TMG; also known as

BETAINE
betaine) is a metabolite of choline that
plays a critical role in methylation
reactions throughout the body. One of
the principal benefits of TMG
supplementation is its ability to
reduce homocysteine
concentrations,59,60 which reduces
exposure to oxidative stress and
inflammation.61,62 TMG levels in the
body have been linked to be"er
cognitive function, particularly
memory and executive function, and
improved mood.63,67
Vitamin D is a unique nutrient

VITAMIN D
because, although dietary sources of
vitamin D do exist, our principle supply
is through sunlight exposure. Making
vitamin D wasn’t much of an issue
throughout evolutionary history. A
sunbathing adult produces the dietary
equivalent of 10,000 to 25,000 IU when
exposed to one minimal erythemal
dose of UVB radiation, which is just
enough to cause a slight pinkness to
the skin 24 hours after exposure.
But things are a lot di#erent today
than they were 100, let alone 1 million

years ago. The most obvious
di#erence is that we spend most of
our time indoors and away from
sunlight. When we do go outside, we
are wearing clothes that prevent
sunlight from reaching the skin. When
we go to the beach, we use sunscreen
that blocks more than 99% of UVB
radiation. This exposure problem
becomes all the more ominous when
we consider the role that skin
pigmentation, geographical location,
and genetics play in determining our
ability to synthesize and utilize vitamin
D.
Adding a li"le vitamin D into the diet

can be a saving grace for those who
cannot obtain su#icient sun exposure.
While everyone will require di#erent
amounts, the Endocrine Society has
recommended that people require
2,000 to 10,000 IU per day to achieve
vitamin D su#iciency.112
Numerous meta-analyses have also

linked low vitamin D levels to an
increased risk of dying from any
cause,113–117 cardiovascular
113,114,116,118
diseases,113,114,116,118, and
cancer.113,114,116,119,120
Vitamin E is not one single chemical

VITAMIN E
but instead refers to eight related fat-
soluble compounds: four tocopherols
and four tocotrienols. Most
supplements use alpha-tocopherol as
the source of vitamin E, but the
tocotrienols have unique biologic
functions not shared by the
tocopherols.121
Gamma-tocopherol and delta-

tocotrienol have emerged as vitamin E
molecules with functions in health and
disease that are clearly distinct from
that of alpha-tocopherol.
Studies in humans suggest that

tocotrienols possess incredibly potent
antioxidant and anti-inflammatory
e#ects that lend them benefits
towards cardiovascular health,
immune function, neuroprotection,
and healthy aging. They have shown
powerful benefits to preventing:122,123
124,125,126
The Metabolic minerals blend provides

METABOLIC MINERALS
most of the major minerals needed by
the body as highly bioavailable amino
acid chelates:
Calcium is the major structural
mineral of our bones and teeth
and a critical messenger in cell-
signaling pathways. When
dietary calcium is inadequate,
the body draws upon its
reserves in the skeleton to
supply what is needed.
Magnesium is required for over
300 enzymes in the body to
function properly, thereby
regulating muscle contractions,
blood pressure, insulin
signaling, and the synthesis of
DNA and proteins.
Manganese plays an important
role as both a constituent of
enzymes and an activator of
other enzyme’s activity,
including those involved in
antioxidant protection,
metabolism, and bone
development.
Selenium exerts various
biological e#ects as part of
larger amino acid structures,

with some of the best known
being involved in glutathione
and thyroid hormone
production.
Zinc plays an important role in
regulating gene expression,
ensuring the proper function of
proteins, and catalyzing vital
chemical reactions within the
body.
Copper is an essential cofactor
for numerous redox reactions
within energy production, iron
metabolism,
neurotransmission, and
connective tissue development.
It also serves as an essential
component of the antioxidant
enzyme, superoxide dismutase.
Boron has key benefits for the
skeletal system, anti-
inflammatory benefits, dental
health, and hormonal health
(particularly testosterone and
estrogen).180,182,183
Molybdenum is a component of
several enzymes within the
body required for the
metabolism of amino acids, DNA

and RNA, and drugs.
Chromium is critical for blood
sugar management and
correcting insulin resistance.
Our formula also contains the wonder

FULVIC AND HUMIC
compounds fulvic and humic acid.
ACIDD
Shilajit is a mixture of minerals used
traditionally in Ayurveda, with the main
bioactives being fulvic and humic
acids. It’s believed to help transport
other nutrients in the body, facilitate
energy production within
mitochondria, and supports the body’s
detoxification
processes.184,185 Clinical trials have
shown that fulvic and humic acid
supplementation can:
Improve mitochondrial health

and decrease fatigue (increases
energy levels).
Increase total and free
testosterone levels in
men.186,187
Improve sperm parameters.187
Binds and detoxifies heavy
metals and other pollutants.

Supports gut health.
Improves immune function.
Reduce oxidative stress.187
Improves skin health.
Improves brain health.
Favorably alter gene expression
in skeletal muscle for improved
neuromuscular signaling and
regeneration (faster recovery
from workouts).188
Enhance absorption of other
compounds it is paired with.
Citrus bioflavonoids are the

CITRUS BIOFLAVANOIDS
phytonutrients found in citrus fruits,
the most notable being hesperidin and
naringenin. They are powerful
antioxidant, immune-boosting, and
anti-inflammatory compounds that
have shown e#icacy for preventing
decreases in NAD+ that occur from
metabolic dysfunction.68
Their anti-inflammatory e#ects have

led to an intensive investigation for
ba"ling cancer and cardiovascular
disease.69,70 Of course, part of this
benefit comes from preventing
mitochondrial dysfunction.71
To give an idea of the energy-boosting

properties of citrus bioflavonoids, one
study found that supplementation in
combination with another citrus
compound, synephrine, could increase
metabolic rate by 18%.72
Acerola berries are a rich source of

ACEROLA BERRY
vitamin C (1–4.5%) and
EXTRACT
phytochemicals.73,74 In fact, the
vitamin C of acerola berries is more
bioavailable and be"er retained in the
body than vitamin C supplements.75
Research has implicated acerola in

numerous beneficial aspects of our
health:
Protects against DNA

damage.76–79
Reduces fat cell dysfunction,
oxidative stress, and low-grade
inflammation that develop
alongside obesity.78,80
Promotes greater antioxidant
potential within detoxification
organs like the liver.81
Increases brain mitochondrial
function and energy
production.82
Camu camu is a berry native to the

CAMU CAMU
Amazon rainforest. It’s renowned for
its high levels of vitamin C (2.4–3%)
and phytochemicals that have been
consistently associated with health
benefits.83–86 Compared to other
exotic fruits, camu camu has some of
the highest phytochemical
concentrations and antioxidant
abilities.87,88> In animals, camu camu
has been shown to reduce
inflammation,89 reduce fat gain and
mitigate metabolic
dysfunction,90 protect the liver from
injury. 91 In humans, drinking 70 mL/d
(1/3rd cup) of camu camu juice for just
one week reduced markers of
oxidative stress and
inflammation.92 Camu camu has also
been shown to blunt the glycemic
response to eating,93 and improve
blood vessel function.94
Amla is an Ayurvedic herb used

AMLA
traditionally for enhancing vitality and
promoting longevity. It’s a potent
supplier of vitamin C and bioactive
phytochemicals that are able to
promote mitochondrial biogenesis,
up-regulate antioxidant systems, and

facilitate energy production.95 These
e#ects also lend it great therapeutic
potential as a neuroprotective,96 anti-
cancer,97 and general health agent.98
In particular, amla has incredible

benefits towards blood glucose and
blood lipids that have been
documented in both healthy adults
and adults with metabolic dysfunction
(type 2 diabetes, metabolic syndrome,
and dyslipidemia). The e#ects are
comparable to those from diabetes
drugs and statins.
In a study of non-diabetic and type 2

diabetic adults, 1–3 g/d of amla for 3
weeks reduced fasting blood glucose
by 15–30% in non-diabetic adults and
by 34–37% in those with type 2
diabetes, being as e#ective as the
drug glibenclamide.99 It also lowered
LDL-C and triglycerides, while HDL-C
increased.
In healthy adults, taking 500 mg/d of

amla for 4 weeks improved vascular
fluidity, reduced an index for vascular
age, and reduced markers of oxidative
100
stress.100
A double-blind, randomized controlled

trial using 1000 mg/d of amla for 12
weeks in dyslipidemic patients found
that it reduced the atherogenic index
by 39%, triglycerides by 15%, and LDL-
C by 20%. 101
A randomized controlled trial

comparing 500–1000 mg/d of amla
with a statin in people with type 2
diabetes found that all were
equivalently e#ective at improving
endothelial function, increasing nitric
oxide, reducing oxidative stress, and
reducing inflammation.102 Amla was
nearly as e#ective at improving blood
lipids too.
In a study of individuals with GERD,

2000 mg/d of amla for 4 weeks
significantly reduced the frequency
and severity of heartburn.105
In a double-blind, randomized
controlled trial comparing 500 and
1000 mg/d of amla for 12 weeks in
individuals with metabolic syndrome,
both doses similarly reduced oxidative
stress (20–30%), increased
glutathione concentrations (24–50%),

increased nitric oxide (40–50%), and
reduced inflammation (40–54%).103 It
also positively a#ected blood lipids.
A clinical study of adults with

dyslipidemia found that 500 mg/d of
amla for 6 weeks was as e#ective as a
statin at correcting the blood lipid
abnormalities.104
Rutin is one of the most well-

RUTIN
researched phytochemicals in
existence, documented to provide
potent protection against oxidative
stress and protect cells throughout
the body from insult and
injury.106 Research has shown that
rutin is protective against numerous
diseases and conditions, including:107–
109
Neuroinflammation
Nerve damage
Alzheimer’s disease
Depression
Stroke
Arthritis
Diabetes
Hyperlipidemia
Hypothyroidism
High blood pressure
Ulcers
Asthma
Osteoporosis
Cataracts
Cancer
Fatigue
Organ damage
In individuals with type 2 diabetes, 180

mg/d of rutin plus 480 mg/d of vitamin
C for 8 weeks reduced fasting blood
glucose by 14% and improved quality
of life.110 An earlier study in diabetics
using 500 mg/d for 8 weeks also found
reductions in fasting glucose.111
Chlorella is a microalga providing

CHLORELLA THIN CELL
what’s called the Chlorella Growth
WALL ALGAE
Factor (CGF) — an extract composed
of amino acids, peptides, proteins,
vitamins, sugars, and nucleic acids.128
Studies have shown that chlorella has

potent anti-inflammatory properties
through activating the master anti-
inflammatory regulator nuclear factor
kappa B (NFκB).129 It also reduces
levels of oxidative stress and

increases markers of antioxidant
activity.130
A meta-analysis of 19 randomized
control trials with 797 participants
revealed that Chlorella significantly
decreases fasting blood glucose,
blood pressure, and blood lipids.131
Additionally, it enhances immune
function by stimulating the innate and
adaptive immune soldiers.132 Other
research has shown that it helps
detoxify the body by enhancing the
excretion of toxicants, including heavy
metals.133,134 It’s an all-around amazing
superfood for cardiovascular health,
detoxification, and metabolic health.
Moringa leaf is an important herb in

MORINGA LEAF
Ayurvedic medicine, native to the
Himalayan mountains and India, used
to treat infections, high blood
pressure, and diabetes. Research has
demonstrated it has several beneficial
health e#ects:135
Reducing blood pressure and

blood lipids
Reducing inflammation and
oxidative stress
Reducing insulin resistance and
blood glucose
Reducing DNA damage and
causing cancer cell death
Protecting the liver
Broccoli and cabbage are two powerful

BROCCOLI & CABBAGE
cruciferous vegetables that contain
notable amounts of sulforaphane, a
sulfur-containing compound that
upregulates phase II of the liver’s
detoxification pathways.139,140 This
helps the body neutralize toxicants
and prepare them for excretion.
Dandelion is one of the best-known

DANDELION ROOT
detoxification herbs. Despite being a
EXTRACT
common weed, it’s been used for
centuries in traditional medicine
throughout the world for treating
diabetes and digestive disorders.143
Dandelion has:
Protected cells from damage

and oxidation.144
Reduced inflammation.144–147
Killed cancer cells.148–150
Ultimately, dandelion root is protective

against oxidative stress, fights
infections, and has diuretic e#ects to
help expel neutralized toxicants.151–153
Spirulina is a group of cyanobacteria

SPIRULINA
(not true algae as many believe)
traditionally eaten by native African
populations and the Aztecs of Central
America.154 It is, by far, one of the most
potent health supplements in
existence thanks to a li"le molecule it
contains called C-Phycocyanin.
This bioactive constituent of spirulina
has powerful anti-inflammatory,

antioxidant, antitumor, and
immunostimulating properties thanks
to its ability to inhibit NADPH oxidase
activity,155,156 which serves as an
important source of oxidative stress in
many disease states.157,158 For
example, it’s NADPH oxidase that
drives the glucotoxicity and
pancreatic damage seen in type 2
diabetes.159 Spirulina also protects
against mitochondrial dysfunction and
degeneration.160
The incredible health benefits of
spirulina are evidenced in Gilbert’s
Syndrome, a genetic condition where
individuals have elevated levels of
bilirubin,161 which is structurally similar
to C-phycocyanin and also inhibits
NADPH oxidase.162 People with
Gilbert’s Syndrome have:
A 50% lower risk of death from

any cause compared to the
general population.163
Less oxidative stress.164
Improved blood vessel
function.164
Lower rates of cardiovascular
disease and mortality.165,166
167
Longer telomeres.167
Turmeric is an Ayurvedic spice most

TUMERIC ROOT
well-known for its curcumin bioactive
constituents but is also rich in
numerous other bioactive compounds
that may exert health benefits. Due to
the lower bioavailability of curcumin
from turmeric, most of it passes
through the digestive tract
unabsorbed.
Numerous lines of evidence suggest

that turmeric and curcumin are able to
exert potent antioxidative and anti-
inflammatory e#ects in the digestive
tract, particularly within the colon
thanks to beneficial metabolism of
turmeric by the microbiome. This can
help alleviate inflammatory bowel
diseases and irritable bowel
syndromes,189,190 maintain intestinal
barrier integrity,191 and increase
microbiome diversity.192,193
Of the curcumin that is absorbed,

There is also evidence that curcumin
can help slow cognitive decline with
aging, promote cardiovascular health,
reduce the risk of developing diabetes,

and alleviate other inflammation-
related conditions.194 One of the key
mechanisms by which it exerts these
e#ects is through protecting and
stabilizing mitochondrial membranes,
and helping the body build more
mitochondria from scratch
(mitochondrial biogenesis).195
Ginger is a culinary and medicinal herb

GINGER ROOT
in many cultures, with modern
research confirming it has potent
health benefits. While most people are
familiar with its benefits for treating
nausea, the e#ects extend far beyond
that. Ginger supplementation has
been shown to help ba"le:206,207
Oxidative stress
Inflammation
Cancer
Allergies
Cognitive decline
Diabetes
Inflammatory bowel diseases
Heart disease
Dyslipidemia
Acai berries are a Brazilian superfruit

ACAI
native to the Amazon rainforest. They
have an incredibly high amount of
antioxidants, edging out other
antioxidant-rich fruits like blueberries
and cranberries.213,214 It’s also been
shown to bolster mitochondrial
function and energy production.215
Research has strongly suggested that

acai berries hold promise for ba"ling
chronic diseases through reducing
inflammation and oxidative stress:
Ba"le cardiovascular disease

through reducing blood lipid
oxidation.216–218
Fight cognitive decline with
aging.219–222
Protect against cancer and
reduce its ability to spread and
proliferate.223
Reduce biomarkers of muscle
damage following strenuous
exercise, increase serum
antioxidant status, and lower
blood lipids.224
Protects against liver damage
and inflammation.225
Prevent diabetes by improving

insulin sensitivity and glycemic
control.226–228
Bilberries are a dark purple berry

BILBERRY EXTRACT
originating in Europe and closely
related to blueberries. They possess a
diverse array of anthocyanin
phytochemicals similar to
blueberries,229,230 which have potent
antioxidant and anti-inflammatory
e#ects.231
Regular intake could help fight

cardiovascular disease, diabetes, and
worsening vision.232,233
Over just 3 weeks,

supplementing with 300 mg/d of
bilberry anthocyanins reduced
inflammatory biomarkers by 38–
60%, including suppressing the
activation of the master
inflammatory regulator, NF-
kappaB.234 Similar observations
have been made with bilberry
juice,235 as well as fresh
bilberries.236
After just one dose of bilberry
extract (470 mg), the glucose

and insulin response to a
glucose tolerance test was
reduced by 18%
each.237 Regular consumption
of bilberries over 2 months
improves fasting glucose and
insulin secretion.238
Over 2 months, consuming a
mixture of berries, including
bilberries, improved platelet
function, blood pressure, and
blood
lipids.239 Supplementation with
320 mg bilberry anthocyanins
reduced LDL by 14% and
increased HDL by 11%.240
In those with glaucoma, daily
intake of 120 mg of bilberry
anthocyanins for 2 years
improved visual function by 30%
compared to placebo, whose
vision worsened.241
In those with dry eyes,
supplementing with 160 mg/d of
bilberry extract for just one
month improved dry eye
symptoms by 55%.242
In o#ice workers su#ering from
eye strain, 160–480 mg/d of

bilberry extract reduced eye
fatigue caused by working with
video display terminals.243–245
Maqui berries are an exotic, dark-

MAQUI BERRY
purple fruit native to South America.
They are a rich source of anthocyanins
that possess strong antioxidant
abilities,247,248 and ultimately provide
up to three times more antioxidants
than blackberries, blueberries,
strawberries, or raspberries. 249,250
Studies have shown that maqui

berries could be a powerful ally
against inflammatory
diseases.251
In particular, they have been
shown to reduce inflammation
of blood vessels,252 which could
help prevent cardiovascular
diseases.
In smokers, 2 grams per day
reduced markers of lung
inflammation.253
In a three-month clinical study
in people with prediabetes, 180
mg of maqui berry extract once

daily reduced average blood
sugar levels by 5%, which was
enough to bring their blood
glucose levels back into normal
range.254 It also reduced their
LDL-c and increased their HDL-c.
A small 30-day study in 13
people with dry eyes found that
30–60 mg of a concentrated
maqui berry extract each day
increased tear production by
roughly 50%.255 Follow-up
research demonstrated similar
e#ects after just a month, along
with reduced eye fatigue.256
Blueberries are a rich source of

BLUEBERRY
anthocyanins and pterostilbene
(phytochemicals), and have been
shown to increase the activity of nerve
growth factor (NGF) and brain-derived
neurotrophic factor
(BDNF),270,271 neuropeptides that help
neurons grow, branch toward each
other, and thus communicate
be"er.272 Studies have shown
profound benefits of blueberry
consumption:
In older adults, blueberry juice

improved learning and memory
while reducing depression after
12 weeks of regular
consumption.274
Consuming 390 mg of blueberry
anthocyanins for 12 weeks
improved brain perfusion and
activation in brain areas
associated with cognitive
function in healthy older
adults.275
Increases in brain activity have
also been seen in those with
mild cognitive impairment after
regular supplementation with
the equivalent of 1 cup of whole
blueberries daily.276
Consuming 100 mg of blueberry
extract for 3 months improves
memory.277
Supplementing with 160 mg of
anthocyanins improved memory
and executive cognitive
function after 16 weeks.278
In young and healthy adults,
just 300 grams of mixed berries
(¼ blueberries and half the
phytochemical content coming

from the blueberries) improved
cognitive function for 6 hours
after consumption.279
A systematic review of human
clinical trials found that six of
seven studies reported
improvements in cognition,
including learning and memory,
after anthocyanin-rich food
consumption (like blueberries
and bilberries.)280
Blueberries and their constituent

phytochemicals are also protective
against the development of cancer,
obesity, cardiovascular diseases,
diabetes, bone loss, poor immune
function, fa"y liver, vision loss, and
chronic inflammation.281
Cranberries are best-known for their

CRANBERRY
use in treating urinary tract infections.
And they work. A meta-analysis of 10
studies found that cranberry juice
reduces the likelihood of developing
urinary tract infections,282 especially
in women with recurrent episodes.283
These benefits are owed to the fact

that cranberries are rich in A-type
proanthocyanidins (PACs), in contrast
to the B-type PACs present in most
other fruits. Studies in humans and
animals have shown cranberries to
lower inflammation, increase nitric
oxide synthesis, reduce blood
pressure, manage blood lipids,
improve endothelial function, and
lower oxidative stress.284–286
Drinking cranberry juice

suppresses the growth of H.
pylori infections in both adults
and children after as li"le as 3
weeks.287,288
Regular intake of cranberry juice
(400–500 mL/d) increases HDL
and decreases
LDL,289,290 reduces LDL
oxidation and the beginnings of
atherosclerosis,291,292 lowers
oxidative stress,293 and
improves blood vessel
function.294
Cranberry phytochemicals
prevent mitochondrial function,
oxidative stress, and
inflammation.295,296
Pomegranate is a rich source of

POMEGRANATE
ellagitannins, potent antioxidants that
can be further broken down into other
antioxidant compounds like ellagic
acid and urolithins.257,258 These
substances have been heavily
investigated for their cardiovascular,
anti-cancer, and mitochondrial
benefits.
Regular intake of pomegranate juice

has been shown to reduce blood lipid
oxidation and the accumulation of
plaque in arteries over the course of 1–
3 years,259 particularly in those who
have higher levels of oxidative
stress.260,261 Pomegranate e#ectively
uses its potent antioxidant abilities to
prevent the development of
atherosclerosis.262,263
Additionally, pomegranate has been

shown to help prevent and treat
several types of cancer, including
prostate, breast, lung, colon, and skin
cancers.264,265 A phase II clinical trial
in men with prostate cancer showed
that regularly consuming
pomegranate juice caused a 12%

decrease in cell proliferation, a 17%
increase in apoptosis, a 23% increase
in serum nitric oxide, a reduction in
oxidative stress, and a reduction in
blood lipid oxidation.266
By far the most important benefit of

pomegranates is their ability to
stimulate mitochondrial function and
mitophagy.267 Mitophagy
(mitochondria + autophagy) is a
quality control pathway that preserves
mitochondrial health by targeting
damaged mitochondria for autophagic
degradation, making anything that
facilitates mitophagy absolutely vital
for optimal health and disease
prevention.
Consuming pomegranate leads to the

creation of urolithin A by our gut
microbes, which is then absorbed into
circulation where it induces mitophagy
throughout the body and potentially
extends lifespan in animal
research.268 In particular, urolithin A
is the single most potent activator of
mitophagy (mitochondrial repair) in
existence. And this compound is
exclusively made from primarily ellagic

acid in the diet, and pomegranate is
one of the richest sources of ellagic
acid. In fact, giving healthy adult
humans urolithin A daily for one
month improved markers of
mitochondrial function!269
7 MAJOR THINGS YOU SHOULD

EXPECT FROM YOUR
MULTIVITAMIN...AND WHAT ENERGY
ESSENTIALS & SUPERFOODS
DELIVERS:
!
SUPREME QUALITY
Carefully sourced, premium ingredients in the right ratios that will get you
results. Taking Energy Essentials & Superfoods won’t make you feel sick, and it
won’t leech nutrients from your body.
EFFECTIVE DOSAGES
EFFECTIVE DOSAGES
Serving sizes that actually do something for your health. Feel more energetic
and notice an overall greater sense of wellness after just a few daily doses.
(Most supplement companies put in only 1/10th to 1/50th of the real e#ective
doses. We are the only company making a product like this that actually uses
real does of the ingredients. For example, 1,500mg of spirulina instead of 50 mg,
or 1,500 mg of pomegranate instead of 30 mg. Look at the label of ours and
compare it to other brands to see for yourself.)
!
BIOAVAILABLE INGREDIENTS
Absorption is guaranteed, no ma"er the state of your gut health. Your body also
knows how to receive each of the 45 vitamins, minerals, and superfoods in this
multivitamin - at the same time. (No need to worry about competing nutrients.)
!
COMPLETE TRANSPARENCY
Zero hidden ingredients, fillers, junk, or harmful synthetics. What you see on
the label is what you get - and what your body deserves.
!
RESEARCH-BASED FORMULATION
Pure science in every serving. No gimmicks. No marketing BS. Just mountains of
science proving WHY you need all 45 ingredients in Energy Essentials &
Superfoods.
Superfoods.
!
MANUFACTURING BEST PRACTICES
Manufactured in the U.S. in an FDA-approved facility. Each bo"le is
independently lab-verified for purity, consistency, and quality. Delivered to your
door exactly as it was created - a next-generation, ultra-premium multivitamin
that’s like nothing else out there.
Even if you don’t think you need it.

The bad press around multivitamins is rampant, but it’s not entirely accurate. See
below, where I bust some pre"y big multivitamin myths. (And prove why Energy
Essentials should be a key player in your supplement lineup.)
Even if you haven’t taken a multivitamin in

years.
Think you’re doing “just fine” without a high-quality supplement? Take another look at
the long list of ways Energy Essentials & Superfoods can help you and see how much
more your body can benefit when you add it to your daily routine. (There are 36 known
benefits!)
Even if the one you’re currently taking is

"good enough".
I promise you, Energy Essentials & Superfoods is light years be"er than any other
multivitamin you might be loyal to..Because, unlike just about every big name brand,
each of the 45 ingredients in Energy Essentials & Superfoods are:
EASILY ABSORBED
No one wants to spend money on a supplement that moves right through the body,
including us!
Enhanced absorption is KEY, so we’ve formulated Energy Essentials & Superfoods to

include ONLY the most bioavailable forms of each of the 45 vitamins, minerals,
botanicals, and potent antioxidants on the label.
You won’t find a single cheap or synthetic ingredient that could compromise
absorption – or your health. (See for yourself – complete details below!)
And if you’re worried about certain ingredients ‘competing’ with each other – don’t be.
When provided in their most bioavailable forms (in e#ective doses), your body is
designed to absorb every nutrient in Energy Essentials & Superfoods. Yes – even when
taken at the same time.
We’ve also included critical absorption enhancers like fulvic acid and humic acid to
further optimize absorptions and shu"le these powerful nutrients directly into your
cells.
IN EFFECTIVE DOSES
As is the case with our entire line of Energy Blueprint supplements, every dose of every
ingredient in Energy Essentials & Superfoods is substantial enough to create positive
change.
That means the recommended daily dose of Energy Essentials & Superfoods is robust.
While the serving size of most multivitamins is 1-3 grams, we suggest you take one 15-
gram scoop of Energy Essentials. Every day.
Because here’s the hard truth — you simply cannot fit everything your body needs into
‘1-a-day’ or even 2 capsules (and anyone who tells you otherwise does NOT care about
ge"ing you results).
While that may seem like an overload, I promise you — every ingredient ratio is
perfectly balanced and in line with exactly what your body needs to pump out
abundant energy.
Not too much to do harm, not too li"le to do nothing. That’s the key. Our formulation is
just right and is just what your body needs to fill in any nutrient gaps and optimize your
health and energy.
SAFE TO TAKE
Whether your nutrient levels are already “normal” or need a bet of a boost, Energy
Essentials is completely safe.*
There are zero synthetics or harmful ingredients that could harm you or make you feel
ill.
And every single one of the superior quality vitamins, minerals, and superfoods in our
premium formulation are:
Sourced to the highest standards and independently lab certified

Non GMO, gluten-free, soy-free, dairy-free
Proven by research to have zero negative side e#ects
Considered for long-term safety (no toxic build-up)
Guaranteed to work WITH your body, not against it (no leaching of critical
nutrients
BONUS: We’ve also carefully curated this stack of ingredients to minimize allergenic
potential.
*Of course, consult your physician before taking EE if you are pregnant or have a pre-
existing condition, or are taking any pharmaceuticals that could react negatively with
EE.
What people say about Energy

Essentials & Superfoods
“
Ari Whi"en. I have only this
week been able to start taking
“
I was skeptical of your
products... I finally got around
Energy Essentilas, have had it a
to trying all three of your
while. OMG... only 3/4 a scoop. It
products and
is just amazing. I am now 71 and
honestly...changed my life.
for the past week of taking this
Especially Energy Essentails. I
my energy has been be"er than
can’t express the di#erence
ever. Clearly I was missing
I’ve noticed in my health with
something that the this formula
that."
has because I feel sooooo
much be"er. I have immense Ma#hew
energy. Thank you so much."
Kristine G.
Get Your Energy Essentials &

Superfoods Now!
ENERGY ENERGY
ESSENTIALS & ESSENTIALS &
SUPERFOODS SUPERFOODS
$100.00 $179.00
" ADD TO CART " ADD TO CART

Worldwide Shipping (FREE Shipping within the U.S.)*

* For international orders: All shipments are shipped Duties, Customs, & Taxes unpaid.
Buyer is responsible for delivery fees.
Reference
Reference
1. See, A. W.-M. & Clage"-Dame, M. The temporal requirement for vitamin A in the
developing eye: mechanism of action in opticfissure closure and new roles for the
vitamin in regulating cell proliferationand adhesion in the embryonic retina. Dev. Biol.
325, 94–105 (2009).
2. Green, H. N. & Mellanby, E. VITAMIN A AS ANANTI-INFECTIVE AGENT. Br. Med. J. 2, 691–

696 (1928).
3. Raverdeau, M. & Mills, K. H. G. Modulation of Tcell and innate immune responses by

retinoic Acid. J. Immunol. 192, 2953–2958(2014).
4. Borel, P. & Desmarchelier, C. Genetic VariationsAssociated with Vitamin A Status and

Vitamin A Bioavailability. Nutrients 9,(2017).
5. Weber, D. & Grune, T. The contribution ofβ-carotene to vitamin A supply of humans.

Mol. Nutr. Food Res. 56, 251–258(2012).
6. Wajed, S. A., Laird, P. W. & DeMeester, T. R. DNAmethylation: an alternative pathway

to cancer. Ann. Surg. 234, 10–20 (2001).
7. Luczak, M. W. & Jagodziński, P. P. The role of DNAmethylation in cancer development.

Folia Histochem. Cytobiol. 44, 143–154(2006).
8. Iraola-Guzmán, S., Estivill, X. & Rabionet, R. DNAmethylation in neurodegenerative

disorders: a missing link between genome andenvironment? Clin. Genet. 80, 1–14
(2011).
9. Lu, H., Liu, X., Deng, Y. & Qing, H. DNAmethylation, a hand behind neurodegenerative
diseases. Front. Aging Neurosci.5, 85 (2013).
10. Reynolds, E. H., Carney, M. W. & Toone, B. K.Methylation and mood. Lancet 2, 196–
198 (1984).
11. Bo"iglieri, T. Folate, vitamin B12, andneuropsychiatric disorders. Nutr. Rev. 54, 382–
390 (1996).
12. Ganguly, P. & Alam, S. F. Role of homocysteine inthe development of cardiovascular

disease. Nutr. J. 14, 6 (2015).
13. Price, B. R., Wilcock, D. M. & Weekman, E. M.Hyperhomocysteinemia as a Risk Factor

for Vascular Contributions to CognitiveImpairment and Dementia. Front. Aging
Neurosci. 10, 350 (2018).
14. West, R. K. et al. Homocysteine and cognitive functionin very elderly nondemented
subjects. Am. J. Geriatr. Psychiatry 19, 673–677(2011).
15. Garcia, A. & Zanibbi, K. Homocysteine andcognitive function in elderly people. CMAJ
171, 897–904 (2004).
16. More"i, R. & Caruso, P. The Controversial Role ofHomocysteine in Neurology: From
Labs to Clinical Practice. Int. J. Mol. Sci.20, (2019).
17. Wada, T. et al. A new thiamine derivative,S-benzoylthiamine O-monophosphate.

Science 134, 195–196 (1961).
18. Loew, D. Pharmacokinetics of thiamine derivativesespecially of benfotiamine. Int. J.

Clin. Pharmacol. Ther. 34, 47–50 (1996).
19. Xie, F. et al. Pharmacokinetic study of benfotiamineand the bioavailability

assessment compared to thiamine hydrochloride. J. Clin.Pharmacol. 54, 688–695
(2014).
20. Pácal, L., Kuricová, K. & Kaňková, K. Evidence foraltered thiamine metabolism in
diabetes: Is there a potential to oppose gluco-and lipotoxicity by rational
supplementation? World J. Diabetes 5, 288–295(2014).
21. Jain, A., Mehta, R., Al-Ani, M., Hill, J. A. &Winchester, D. E. Determining the Role of
Thiamine Deficiency in Systolic HeartFailure: A Meta-Analysis and Systematic Review.
J. Card. Fail. 21, 1000–1007(2015).
22. Page, G. L. J., Laight, D. & Cummings, M. H.Thiamine deficiency in diabetes mellitus
and the impact of thiamine replacementon glucose metabolism and vascular disease.
Int. J. Clin. Pract. 65, 684–690(2011).
23. Luong, K. V. Q. & Nguyen, L. T. H. The impact ofthiamine treatment in the diabetes
mellitus. J. Clin. Med. Res. 4, 153–160(2012).
24. Thornalley, P. J. et al. High prevalence of low plasmathiamine concentration in

diabetes linked to a marker of vascular disease.Diabetologia 50, 2164–2170 (2007).
25. Hammes, H.-P. et al. Benfotiamine blocks three majorpathways of hyperglycemic

damage and prevents experimental diabeticretinopathy. Nat. Med. 9, 294–299 (2003).
26. Kihm, L. P. et al. Benfotiamine protects againstperitoneal and kidney damage in

peritoneal dialysis. J. Am. Soc. Nephrol. 22,914–926 (2011).
27. Gadau, S. et al. Benfotiamine accelerates the healingof ischaemic diabetic limbs in
mice through protein kinase B/Akt-mediatedpotentiation of angiogenesis and
inhibition of apoptosis. Diabetologia 49,405–420 (2006).
28. Beltramo, E., Nizheradze, K., Berrone, E., Tarallo, S.& Porta, M. Thiamine and
benfotiamine prevent apoptosis induced by highglucose-conditioned extracellular
matrix in human retinal pericytes. Diabetes.Metab. Res. Rev. 25, 647–656 (2009).
29. Verma, S., Reddy, K. & Balakumar, P. The defensivee#ect of benfotiamine in sodium
arsenite-induced experimental vascularendothelial dysfunction. Biol. Trace Elem. Res.
137, 96–109 (2010).
30. Bozic, I. et al. Benfotiamine a"enuates inflammatoryresponse in LPS stimulated

BV-2 microglia. PLoS One 10, e0118372 (2015).
31. Yadav, U. C. S., Kalariya, N. M., Srivastava, S. K.& Ramana, K. V. Protective role of
benfotiamine, a fat-soluble vitamin B1analogue, in lipopolysaccharide-induced
cytotoxic signals in murinemacrophages. Free Radic. Biol. Med. 48, 1423–1434 (2010).
32. Sun, X.-J. et al. Benfotiamine prevents increasedβ-amyloid production in HEK cells
induced by high glucose. Neurosci. Bull. 28,561–566 (2012).
33. Stirban, A. et al. Benfotiamine counteractssmoking-induced vascular dysfunction

in healthy smokers. Int. J. Vasc. Med.2012, 968761 (2012).
34. Stirban, A. et al. Benfotiamine prevents macro- andmicrovascular endothelial

dysfunction and oxidative stress following a mealrich in advanced glycation end
products in individuals with type 2 diabetes.Diabetes Care 29, 2064–2071 (2006).
35. González-Ortiz, M., Martínez-Abundis, E.,Robles-Cervantes, J. A., Ramírez-

Ramírez, V. & Ramos-Zavala, M. G. E#ectof thiamine administration on metabolic
profile, cytokines and inflammatorymarkers in drug-naïve patients with type 2
diabetes. Eur. J. Nutr. 50, 145–149(2011).
36. Stracke, H., Gaus, W., Achenbach, U., Federlin, K.& Bretzel, R. G. Benfotiamine in
diabetic polyneuropathy (BENDIP): resultsof a randomised, double blind, placebo-
controlled clinical study. Exp. Clin.Endocrinol. Diabetes 116, 600–605 (2008).
37. Winkler, G. et al. E#ectiveness of di#erentbenfotiamine dosage regimens in the

treatment of painful diabetic neuropathy.Arzneimi"elforschung 49, 220–224 (1999).
38. Haupt, E., Ledermann, H. & Köpcke, W. Benfotiaminein the treatment of diabetic
polyneuropathy–a three-week randomized, controlledpilot study (BEDIP study). Int. J.
Clin. Pharmacol. Ther. 43, 71–77 (2005).
39. Nikolić, A., Kacar, A., Lavrnić, D., Basta, I. &Apostolski, S. [The e#ect of
benfothiamine in the therapy of diabeticpolyneuropathy]. Srp. Arh. Celok. Lek. 137,
594–600 (2009).
40. Garg, S., Syngle, A. & Vohra, K. E#icacy andtolerability of advanced glycation end-
products inhibitor in osteoarthritis: arandomized, double-blind, placebo-controlled
study. Clin. J. Pain 29, 717–724(2013).
41. Pan, X. et al. Long-Term Cognitive Improvement AfterBenfotiamine Administration

in Patients with Alzheimer’s Disease. Neurosci.Bull. 32, 591–596 (2016).
42. Leclerc, D., Sibani, S. & Rozen, R. Molecularbiology of methylenetetrahydrofolate

reductase (MTHFR) and overview ofmutations/polymorphisms. in MTHFR
polymorphisms and disease 15–34 (CRC Press,2005).
43. Guenther, B. D. et al. The structure and properties ofmethylenetetrahydrofolate

reductase from Escherichia coli suggest how folateameliorates human
hyperhomocysteinemia. Nat. Struct. Biol. 6, 359–365 (1999).
44. Yamada, K., Chen, Z., Rozen, R. & Ma"hews, R. G.E#ects of common polymorphisms
on the properties of recombinant humanmethylenetetrahydrofolate reductase. Proc.
Natl. Acad. Sci. U. S. A. 98,14853–14858 (2001).
45. García-Minguillán, C. J. et al. Riboflavin statusmodifies the e#ects of

methylenetetrahydrofolate reductase (MTHFR) andmethionine synthase reductase
(MTRR) polymorphisms on homocysteine. Genes Nutr.9, 435 (2014).
46. Anandam, K. Y. et al. E#ect of the proinflammatorycytokine TNF-α on intestinal

riboflavin uptake: inhibition mediated viatranscriptional mechanism(s). Am. J. Physiol.
Cell Physiol. 315, C653–C663(2018).
47. Hoey, L., McNulty, H. & Strain, J. J. Studies ofbiomarker responses to intervention
with riboflavin: a systematic review. Am.J. Clin. Nutr. 89, 1960S–1980S (2009).
48. McNulty, H. et al. Riboflavin lowers homocysteine inindividuals homozygous for the
MTHFR 677C'T polymorphism. Circulation 113,74–80 (2006).
49. McNulty, H., Strain, J. J., Hughes, C. F. & Ward,M. Riboflavin, MTHFR genotype and
blood pressure: A personalized approach toprevention and treatment of hypertension.
Mol. Aspects Med. 53, 2–9 (2017).
50. Horigan, G. et al. Riboflavin lowers blood pressure incardiovascular disease

patients homozygous for the 677C–>T polymorphism inMTHFR. J. Hypertens. 28, 478–
486 (2010).
51. Wilson, C. P. et al. Riboflavin o#ers a targetedstrategy for managing hypertension in

patients with the MTHFR 677TT genotype: a4-y follow-up. Am. J. Clin. Nutr. 95, 766–772
(2012).
52. Wilson, C. P. et al. Blood pressure in treatedhypertensive individuals with the

MTHFR 677TT genotype is responsive tointervention with riboflavin: findings of a
targeted randomized trial.Hypertension 61, 1302–1308 (2013).
53. Zempleni, J., Galloway, J. R. & McCormick, D. B.Pharmacokinetics of orally and

intravenously administered riboflavin in healthyhumans. Am. J. Clin. Nutr. 63, 54–66
(1996).
54. Madigan, S. M. et al. Riboflavin and vitamin B-6intakes and status and biochemical
response to riboflavin supplementation infree-living elderly people. Am. J. Clin. Nutr.
68, 389–395 (1998).
55. Braidy, N. et al. Role of Nicotinamide AdenineDinucleotide and Related Precursors

as Therapeutic Targets for Age-RelatedDegenerative Diseases: Rationale,
Biochemistry, Pharmacokinetics, and Outcomes.Antioxid. Redox Signal. 30, 251–294
(2019).
56. Rajman, L., Chwalek, K. & Sinclair, D. A.Therapeutic Potential of NAD-Boosting

Molecules: The In Vivo Evidence. CellMetab. 27, 529–547 (2018).
57. Johnson, S. & Imai, S.-I. NAD + biosynthesis,aging, and disease. F1000Res. 7, 132
(2018).
58. McRae, M. P. Treatment of hyperlipoproteinemia withpantethine: A review and

analysis of e#icacy and tolerability. Nutr. Res. 25,319–333 (2005).
59. Steenge, G. R., Verhoef, P. & Katan, M. B. Betainesupplementation lowers plasma

homocysteine in healthy men and women. J. Nutr.133, 1291–1295 (2003).
60. Olthof, M. R., van Vliet, T., Boelsma, E. &Verhoef, P. Low dose betaine
supplementation leads to immediate and long termlowering of plasma homocysteine
in healthy men and women. J. Nutr. 133,4135–4138 (2003).
61. Rajaie, S. & Esmaillzadeh, A. Dietary choline andbetaine intakes and risk of
cardiovascular diseases: review of epidemiologicalevidence. ARYA Atheroscler. 7, 78–
86 (2011).
62. Zhao, G. et al. Betaine in Inflammation: MechanisticAspects and Applications.

Front. Immunol. 9, 1070 (2018).
63. Eussen, S. J. P. M. et al. The association of betaine,homocysteine and related

metabolites with cognitive function in Dutch elderlypeople. Br. J. Nutr. 98, 960–968
(2007).
64. Knight, L. S., Piibe, Q., Lambie, I., Perkins, C.& Yancey, P. H. Betaine in the Brain:
Characterization of Betaine Uptake,its Influence on Other Osmolytes and its Potential
Role in Neuroprotection fromOsmotic Stress. Neurochem. Res. 42, 3490–3503 (2017).
65. Kim, S. J., Lee, L., Kim, J. H., Lee, T. H. &Shim, I. Antidepressant-like e#ects of lycii
radicis cortex and betaine in theforced swimming test in rats. Biomol. Ther. 21, 79–83
(2013).
66. Di Pierro, F., Orsi, R. & Se"embre, R. Role ofbetaine in improving the antidepressant
e#ect of S-adenosyl-methionine inpatients with mild-to-moderate depression. J.
Multidiscip. Healthc. 8, 39–45(2015).
67. Di Pierro, F. & Se"embre, R. Preliminary resultsof a randomized controlled trial

carried out with a fixed combination ofS-adenosyl-L-methionine and betaine versus
amitriptyline in patients with milddepression. Int. J. Gen. Med. 8, 73–78 (2015).
68. Boesten, D. M. P. H. J., von Ungern-Sternberg, S. N.I., den Hartog, G. J. M. & Bast, A.
Protective Pleiotropic E#ect ofFlavonoids on NAD+ Levels in Endothelial Cells Exposed
to High Glucose. Oxid.Med. Cell. Longev. 2015, 894597 (2015).
69. Benavente-García, O. & Castillo, J. Update on usesand properties of citrus

flavonoids: new findings in anticancer,cardiovascular, and anti-inflammatory activity.
J. Agric. Food Chem. 56,6185–6205 (2008).
70. Tejada, S. et al. Potential Anti-inflammatory E#ectsof Hesperidin from the Genus
Citrus. Curr. Med. Chem. 25, 4929–4945 (2018).
71. Kumar, A., Prakash, A. & Dogra, S. Naringinalleviates cognitive impairment,

mitochondrial dysfunction and oxidative stressinduced by D-galactose in mice. Food
Chem. Toxicol. 48, 626–632 (2010).
72. Stohs, S. J. et al. E#ects of p-synephrine alone andin combination with selected
bioflavonoids on resting metabolism, bloodpressure, heart rate and self-reported
mood changes. Int. J. Med. Sci. 8,295–301 (2011).
73. Prakash, A. & Baskaran, R. Acerola, an untappedfunctional superfruit: a review on
latest frontiers. J. Food Sci. Technol. 55,3373–3384 (2018).
74. Cardoso, P. C., Tomazini, A. P. B., Stringheta, P. C.,Ribeiro, S. M. R. & Pinheiro-

Sant’Ana, H. M. Vitamin C and carotenoids inorganic and conventional fruits grown in
Brazil. Food Chem. 126, 411–416(2011).
75. Uchida, E. et al. Absorption and excretion of ascorbicacid alone and in acerola
(Malpighia emarginata) juice: comparison in healthyJapanese subjects. Biol. Pharm.
Bull. 34, 1744–1747 (2011).
76. Nunes, R. da S. et al. Antigenotoxicity andantioxidant activity of Acerola fruit

(Malpighia glabra L.) at two stages ofripeness. Plant Foods Hum. Nutr. 66, 129–135
(2011).
77. Nunes, R. D. S. et al. Genotoxic and antigenotoxicactivity of acerola (Malpighia

glabra L.) extract in relation to the geographicorigin. Phytother. Res. 27, 1495–1501
(2013).
78. Le#a, D. D. et al. Corrective e#ects of acerola(Malpighia emarginata DC.) juice

intake on biochemical and genotoxicalparameters in mice fed on a high-fat diet.
Mutat. Res. 770, 144–152 (2014).
79. Horta, R. N. et al. Protective e#ects of acerolajuice on genotoxicity induced by iron

in vivo. Genet. Mol. Biol. 39, 122–128(2016).
80. Dias, F. M. et al. Acerola (Malpighia emarginata DC.)juice intake protects against
alterations to proteins involved in inflammatoryand lipolysis pathways in the adipose
tissue of obese mice fed a cafeteriadiet. Lipids Health Dis. 13, 24 (2014).
81. Le#a, D. D. et al. E#ects of Supplemental AcerolaJuice on the Mineral

Concentrations in Liver and Kidney Tissue Samples of MiceFed with Cafeteria Diet.
Biol. Trace Elem. Res. 167, 70–76 (2015).
82. Le#a, D. D. et al. E#ects of Acerola (Malpighiaemarginata DC.) Juice Intake on Brain
Energy Metabolism of Mice Fed a CafeteriaDiet. Mol. Neurobiol. 54, 954–963 (2017).
83. Justi, K. C., Visentainer, J. V., Evelázio de Souza,N. & Matsushita, M. Nutritional
composition and vitamin C stability instored camu-camu (Myrciaria dubia) pulp. Arch.
Latinoam. Nutr. 50, 405–408(2000).
84. Fracasse"i, D., Costa, C., Moulay, L. &Tomás-Barberán, F. A. Ellagic acid derivatives,
ellagitannins,proanthocyanidins and other phenolics, vitamin C and antioxidant
capacity oftwo powder products from camu-camu fruit (Myrciaria dubia). Food Chem.
139,578–588 (2013).
85. Langley, P. C., Pergolizzi, J. V., Jr, Taylor, R., Jr& Ridgway, C. Antioxidant and
associated capacities of Camu camu (Myrciariadubia): a systematic review. J. Altern.
Complement. Med. 21, 8–14 (2015).
86. Fidelis, M. et al. Camu-camu seed (Myrciaria dubia) –From side stream to
anantioxidant, antihyperglycemic, antiproliferative,antimicrobial, antihemolytic, anti-
inflammatory, and antihypertensiveingredient. Food Chem. 310, 125909 (2020).
87. De Souza Schmidt Gonçalves, A. E., Lajolo, F. M. &Genovese, M. I. Chemical

composition and antioxidant/antidiabetic potential ofBrazilian native fruits and
commercial frozen pulps. J. Agric. Food Chem. 58,4666–4674 (2010).
88. Genovese, M. I., Da Silva Pinto, M., De Souza SchmidtGonçalves, A. E. & Lajolo, F. M.
Bioactive Compounds and AntioxidantCapacity of Exotic Fruits and Commercial
Frozen Pulps from Brazil. Food Sci.Technol. Int. 14, 207–214 (2008).
89. Neri-Numa, I. A., Soriano Sancho, R. A., Pereira, A.P. A. & Pastore, G. M. Small
Brazilian wild fruits: Nutrients, bioactivecompounds, health-promotion properties and
commercial interest. Food Res. Int.103, 345–360 (2018).
90. Nascimento, O. V., Boleti, A. P. A., Yuyama, L. K. O.& Lima, E. S. E#ects of diet
supplementation with Camu-camu (Myrciariadubia HBK McVaugh) fruit in a rat model
of diet-induced obesity. An. Acad.Bras. Cienc. 85, 355–363 (2013).
91. Akachi, T. et al. 1-methylmalate from camu-camu(Myrciaria dubia) suppressed D-

galactosamine-induced liver injury in rats.Biosci. Biotechnol. Biochem. 74, 573–578
(2010).
92. Inoue, T., Komoda, H., Uchida, T. & Node, K.Tropical fruit camu-camu (Myrciaria
dubia) has anti-oxidative andanti-inflammatory properties. J. Cardiol. 52, 127–132
(2008).
93. Balisteiro, D. M., Araujo, R. L. de, Giacaglia, L. R.& Genovese, M. I. E#ect of clarified
Brazilian native fruit juices onpostprandial glycemia in healthy subjects. Food Res. Int.
100, 196–203 (2017).
94. Miyashita, T. et al. Data on a single oral dose ofcamu camu (Myrciaria dubia)
pericarp extract on flow-mediated vasodilation andblood pressure in young adult
humans. Data Brief 16, 993–999 (2018).
95. Yamamoto, H. et al. Amla Enhances Mitochondrial SpareRespiratory Capacity by

Increasing Mitochondrial Biogenesis and AntioxidantSystems in a Murine Skeletal
Muscle Cell Line. Oxid. Med. Cell. Longev. 2016,1735841 (2016).
96. Husain, I. et al. Exploring the multifacetedneuroprotective actions of Emblica

o#icinalis (Amla): a review. Metab. BrainDis. 34, 957–965 (2019).
97. Baliga, M. S. & Dsouza, J. J. Amla (Emblicao#icinalis Gaertn), a wonder berry in the
treatment and prevention of cancer.Eur. J. Cancer Prev. 20, 225–239 (2011).
98. Krishnaveni, M. & Mirunalini, S. Therapeuticpotential of Phyllanthus emblica (amla):

the ayurvedic wonder. J. Basic Clin.Physiol. Pharmacol. 21, 93–105 (2010).
99. Akhtar, M. S., Ramzan, A., Ali, A. & Ahmad, M.E#ect of Amla fruit (Emblica o#icinalis
Gaertn.) on blood glucose and lipidprofile of normal subjects and type 2 diabetic
patients. Int. J. Food Sci.Nutr. 62, 609–616 (2011).
100. Kapoor, M. P., Suzuki, K., Derek, T., Ozeki, M. &Okubo, T. Clinical evaluation of
Emblica O#icinalis Gatertn (Amla) in healthyhuman subjects: Health benefits and
safety results from a randomized,double-blind, crossover placebo-controlled study.
Contemp Clin Trials Commun17, 100499 (2020).
101. Upadya, H. et al. A randomized, double blind, placebocontrolled, multicenter

clinical trial to assess the e#icacy and safety ofEmblica o#icinalis extract in patients
with dyslipidemia. BMC Complement.Altern. Med. 19, 27 (2019).
102. Usharani, P., Fatima, N. & Muralidhar, N. E#ectsof Phyllanthus emblica extract on
endothelial dysfunction and biomarkers ofoxidative stress in patients with type 2
diabetes mellitus: a randomized,double-blind, controlled study. Diabetes Metab.
Syndr. Obes. 6, 275–284 (2013).
103. Usharani, P., Merugu, P. L. & Nutalapati, C.Evaluation of the e#ects of a

standardized aqueous extract of Phyllanthusemblica fruits on endothelial
dysfunction, oxidative stress, systemicinflammation and lipid profile in subjects with
metabolic syndrome: arandomised, double blind, placebo controlled clinical study.
BMC Complement.Altern. Med. 19, 97 (2019).
104. Gopa, B., Bha", J. & Hemavathi, K. G. Acomparative clinical study of hypolipidemic
e#icacy of Amla (Emblica o#icinalis)with 3-hydroxy-3-methylglutaryl-coenzyme-A
reductase inhibitor simvastatin.Indian J. Pharmacol. 44, 238–242 (2012).
105. Karkon Varnosfaderani, S. et al. E#icacy and safetyof Amla (Phyllanthus emblica
L.) in non-erosive reflux disease: a double-blind,randomized, placebo-controlled
clinical trial. J. Integr. Med. 16, 126–131(2018).
106. Hosseinzadeh, H. & Nassiri-Asl, M. Review of theprotective e#ects of rutin on the

metabolic function as an important dietaryflavonoid. J. Endocrinol. Invest. 37, 783–788
(2014).
107. Al-Dhabi, N. A., Arasu, M. V., Park, C. H. & Park,S. U. An up-to-date review of rutin
and its biological and pharmacologicalactivities. EXCLI J. 14, 59–63 (2015).
108. Ganeshpurkar, A. & Saluja, A. K. ThePharmacological Potential of Rutin. Saudi

Pharm J 25, 149–164 (2017).
109. Enogieru, A. B., Hayle", W., Hiss, D. C., Bardien, S.& Ekpo, O. E. Rutin as a Potent
Antioxidant: Implications forNeurodegenerative Disorders. Oxid. Med. Cell. Longev.
2018, 6241017 (2018).
110. Ragheb, S. R., El Wakeel, L. M., Nasr, M. S. &Sabri, N. A. Impact of Rutin and Vitamin
C combination on oxidative stress andglycemic control in patients with type 2
diabetes. Clin Nutr ESPEN 35, 128–135(2020).
111. Sa"anathan, K., Dhanapal, C. K., Umarani, R. &Manavalan, R. Beneficial health

e#ects of rutin supplementation in patientswith diabetes mellitus. J. Basic Appl.
Pharm. Sci. 1, 227 (2011).
112. Holick, M. F. et al. Evaluation, treatment, andprevention of vitamin D deficiency: an

Endocrine Society clinical practiceguideline. J. Clin. Endocrinol. Metab. 96, 1911–1930
(2011).
113. Gaksch, M. et al. Vitamin D and mortality: Individualparticipant data meta-analysis

of standardized 25-hydroxyvitamin D in 26916individuals from a European consortium.
PLoS One 12, e0170791 (2017).
114. Schö"ker, B. et al. Vitamin D and mortality:meta-analysis of individual participant

data from a large consortium of cohortstudies from Europe and the United States. BMJ
348, g3656 (2014).
115. Garland, C. F. et al. Meta-analysis of all-causemortality according to serum 25-

hydroxyvitamin D. Am. J. Public Health 104,e43–50 (2014).
116. Chowdhury, R. et al. Vitamin D and risk of causespecific death: systematic review
and meta-analysis of observational cohort andrandomised intervention studies. BMJ
348, g1903 (2014).
117. Aspelund, T. et al. E#ect of Genetically Low25-Hydroxyvitamin D on Mortality Risk:

Mendelian Randomization Analysis in 3Large European Cohorts. Nutrients 11, (2019).
118. Gholami, F. et al. The association between circulating25-hydroxyvitamin D and

cardiovascular diseases: a meta-analysis of prospectivecohort studies. BMC
Cardiovasc. Disord. 19, 248 (2019).
119. Zhang,Y. et al. Association between vitamin D supplementation and

mortality:systematic review and meta-analysis. BMJ 366, l4673 (2019).
120. Han, J. et al. 25-Hydroxyvitamin D and Total CancerIncidence and Mortality: A

Meta-Analysis of Prospective Cohort Studies.Nutrients 11, (2019).
121. Sen, C. K., Khanna, S. & Roy, S. Tocotrienols:Vitamin E beyond tocopherols. Life Sci.
78, 2088–2098 (2006).
122. Sen, C. K., Khanna, S. & Roy, S. Tocotrienol: thenatural vitamin E to defend the
nervous system? Ann. N. Y. Acad. Sci. 1031,127–142 (2004).
123. Sylvester, P. W., Kaddoumi, A., Nazzal, S. & ElSayed, K. A. The value of tocotrienols
in the prevention and treatment ofcancer. J. Am. Coll. Nutr. 29, 324S–333S (2010).
124. Aggarwal, B. B., Sundaram, C., Prasad, S. &Kannappan, R. Tocotrienols, the vitamin
E of the 21st century: its potentialagainst cancer and other chronic diseases.
Biochem. Pharmacol. 80, 1613–1631(2010).
125. Sen, C. K., Khanna, S., Rink, C. & Roy, S.Tocotrienols: the emerging face of natural
vitamin E. Vitam. Horm. 76, 203–261(2007).
126. Meganathan, P. & Fu, J.-Y. Biological Propertiesof Tocotrienols: Evidence in Human
Studies. Int. J. Mol. Sci. 17, (2016).
127. Ben Salem, M. et al. Pharmacological Studies ofArtichoke Leaf Extract and Their
Health Benefits. Plant Foods Hum. Nutr. 70,441–453 (2015).
128. Merchant, R. E. & Andre, C. A. A review of recentclinical trials of the nutritional

supplement Chlorella pyrenoidosa in the treatmentof fibromyalgia, hypertension, and
ulcerative colitis. Altern. Ther. HealthMed. 7, 79–91 (2001).
129. Lee, H.-S., Choi, C.-Y., Cho, C. & Song, Y.A"enuating e#ect of chlorella
supplementation on oxidative stress andNFkappaB activation in peritoneal
macrophages and liver of C57BL/6 mice fed onan atherogenic diet. Biosci. Biotechnol.
Biochem. 67, 2083–2090 (2003).
130. Panahi, Y. et al. Investigation of the e#ects ofChlorella vulgaris supplementation

on the modulation of oxidative stress inapparently healthy smokers. Clin. Lab. 59, 579–
587 (2013).
131. Fallah, A. A. et al. E#ect of Chlorellasupplementation on cardiovascular risk

factors: A meta-analysis of randomizedcontrolled trials. Clin. Nutr. 37, 1892–1901
(2018).
132. Kwak, J. H. et al. Beneficial immunostimulatory e#ectof short-term Chlorella

supplementation: enhancement of natural killer cellactivity and early inflammatory
response (randomized, double-blinded,placebo-controlled trial). Nutr. J. 11, 53 (2012).
133. Lee, I. et al. Detoxification of chlorella supplementon heterocyclic amines in
Korean young adults. Environ. Toxicol. Pharmacol. 39,441–446 (2015).
134. Uchikawa, T. et al. Enhanced elimination of tissuemethylmercury in Parachlorella

beijerinckii-fed mice. J. Toxicol. Sci. 36,121–126 (2011).
135. Vergara-Jimenez, M., Almatrafi, M. M. & Fernandez,M. L. Bioactive Components in

Moringa Oleifera Leaves Protect against ChronicDisease. Antioxidants (Basel) 6,
(2017).
136. Lee, D., Nishizawa, M., Shimizu, Y. & Saeki, H.Anti-inflammatory e#ects of dulse
(Palmaria palmata) resulting from thesimultaneous water-extraction of
phycobiliproteins and chlorophyll a. Food Res.Int. 100, 514–521 (2017).
137. Millan-Linares, M. C. et al. Nutraceutical Extractfrom Dulse (Palmaria palmata L.)

Inhibits Primary Human Neutrophil Activation.Mar. Drugs 17, (2019).
138. Mendez, R. et al. Antiobesogenic Potential of SeaweedDulse (Palmaria palmata) in

High-fat Fed C57BL/6 J Mice (P21-014-19). Curr DevNutr 3, (2019).
139. Kim, J. K. & Park, S. U. Current potential healthbenefits of sulforaphane. EXCLI J. 15,
571–577 (2016).
140. de Figueiredo, S. M., Binda, N. S., Nogueira-Machado,J. A., Vieira-Filho, S. A. &

Caligiorne, R. B. The antioxidant propertiesof organosulfur compounds
(sulforaphane). Recent Pat. Endocr. Metab. ImmuneDrug Discov. 9, 24–39 (2015).
141. Zeng, Y. et al. Preventive and Therapeutic Role ofFunctional Ingredients of Barley
Grass for Chronic Diseases in Human Beings.Oxid. Med. Cell. Longev. 2018, 3232080
(2018).
142. Yu, Y.-M., Chang, W.-C., Chang, C.-T., Hsieh, C.-L.& Tsai, C. E. E#ects of young
barley leaf extract and antioxidativevitamins on LDL oxidation and free radical
scavenging activities in type 2diabetes. Diabetes Metab. 28, 107–114 (2002).
143. Wirngo, F. E., Lambert, M. N. & Jeppesen, P. B.The Physiological E#ects of

Dandelion (Taraxacum O#icinale) in Type 2Diabetes. Rev. Diabet. Stud. 13, 113–131
(2016).
144. Ma, C. et al. Anti-inflammatory e#ects of waterextract of Taraxacum mongolicum

hand.-Mazz on lipopolysaccharide-inducedinflammation in acute lung injury by
suppressing PI3K/Akt/mTOR signalingpathway. J. Ethnopharmacol. 168, 349–355
(2015).
145. Hu, G. et al. E#ects of aqueous extracts of TaraxacumO#icinale on expression of

tumor necrosis factor-alpha and intracellularadhesion molecule 1 in LPS-stimulated
RMMVECs. BMC Complement. Altern. Med. 17,38 (2017).
146. Park, C. M., Cho, C. W. & Song, Y. S. TOP 1 and 2,polysaccharides from Taraxacum
o#icinale, inhibit NFκB-mediated inflammationand accelerate Nrf2-induced
antioxidative potential through the modulation ofPI3K-Akt signaling pathway in RAW
264.7 cells. Food Chem. Toxicol. 66, 56–64(2014).
147. Koh, Y.-J., Cha, D.-S., Ko, J.-S., Park, H.-J. &Choi, H.-D. Anti-inflammatory e#ect of
Taraxacum o#icinale leaves onlipopolysaccharide-induced inflammatory responses in
RAW 264.7 cells. J. Med.Food 13, 870–878 (2010).
148. Ovadje, P., Ammar, S., Guerrero, J.-A., Arnason, J. T.& Pandey, S. Dandelion root
extract a#ects colorectal cancer proliferationand survival through the activation of
multiple death signalling pathways.Oncotarget 7, 73080–73100 (2016).
149. Ovadje, P., Hamm, C. & Pandey, S. E#icientinduction of extrinsic cell death by
dandelion root extract in human chronicmyelomonocytic leukemia (CMML) cells. PLoS
One 7, e30604 (2012).
150. Koo, H.-N. et al. Taraxacum o#icinale inducescytotoxicity through TNF-alpha and
IL-1alpha secretion in Hep G2 cells. LifeSci. 74, 1149–1157 (2004).
151. Menghini, L. et al. Antiproliferative, protective andantioxidant e#ects of artichoke,

dandelion, turmeric and rosemary extracts andtheir formulation. Int. J. Immunopathol.
Pharmacol. 23, 601–610 (2010).
152. Lau, D. & Plotkin, B. J. Antimicrobial and biofilme#ects of herbs used in traditional
Chinese medicine. Nat. Prod. Commun. 8,1617–1620 (2013).
153. Clare, B. A., Conroy, R. S. & Spelman, K. Thediuretic e#ect in human subjects of an
extract of Taraxacum o#icinale foliumover a single day. J. Altern. Complement. Med. 15,
929–934 (2009).
154. Ciferri, O. Spirulina, the edible microorganism.Microbiol. Rev. 47, 551–578 (1983).
155. Liu, Q., Huang, Y., Zhang, R., Cai, T. & Cai, Y.Medical Application of Spirulina
platensis Derived C-Phycocyanin. Evid. Based.Complement. Alternat. Med. 2016,
7803846 (2016).
156. McCarty, M. F. Clinical potential of Spirulina as asource of phycocyanobilin. J. Med.

Food 10, 566–570 (2007).
157. Panday, A., Sahoo, M. K., Osorio, D. & Batra, S.NADPH oxidases: an overview from
structure to innate immunity-associatedpathologies. Cell. Mol. Immunol. 12, 5–23
(2015).
158. Bedard, K. & Krause, K.-H. The NOX family ofROS-generating NADPH oxidases:
physiology and pathophysiology. Physiol. Rev.87, 245–313 (2007).
159. McCarty, M. F., Barroso-Aranda, J. & Contreras, F.NADPH oxidase mediates

glucolipotoxicity-induced beta cell dysfunction–clinicalimplications. Med. Hypotheses
74, 596–600 (2010).
160. Nawrocka, D., Kornicka, K., Śmieszek, A. & Marycz,K. Spirulina platensis Improves
Mitochondrial Function Impaired by ElevatedOxidative Stress in Adipose-Derived
Mesenchymal Stromal Cells (ASCs) andIntestinal Epithelial Cells (IECs), and Enhances
Insulin Sensitivity in EquineMetabolic Syndrome (EMS) Horses. Mar. Drugs 15, (2017).
161. Olsson, R. & Stigendal, L. Clinical experiencewith isolated hyperbilirubinemia.

Scand. J. Gastroenterol. 24, 617–622 (1989).
162. Hinds, T. D., Jr & Stec, D. E. Bilirubin, aCardiometabolic Signaling Molecule.

Hypertension 72, 788–795 (2018).
163. Horsfall, L. J., Nazareth, I., Pereira, S. P. &Petersen, I. Gilbert’s syndrome and the
risk of death: a population-basedcohort study. J. Gastroenterol. Hepatol. 28, 1643–
1647 (2013).
164. Maruhashi, T. et al. Hyperbilirubinemia, augmentationof endothelial function, and

decrease in oxidative stress in Gilbert syndrome.Circulation 126, 598–603 (2012).
165. Kundur, A. R., Singh, I. & Bulmer, A. C.Bilirubin, platelet activation and heart
disease: a missing link tocardiovascular protection in Gilbert’s syndrome?
Atherosclerosis 239, 73–84(2015).
166. Goel, A. & Aggarwal, R. Unconjugatedhyperbilirubinemia: a blessing in disguise?

Journal of gastroenterology andhepatology vol. 28 1687–1689 (2013).
167. Tosevska, A. et al. Longer telomeres in chronic,moderate, unconjugated

hyperbilirubinaemia: insights from a human study onGilbert’s Syndrome. Sci. Rep. 6,
22300 (2016).
180. Naghii, M. R., Mofid, M., Asgari, A. R., Hedayati, M.& Daneshpour, M.-S.
Comparative e#ects of daily and weekly boronsupplementation on plasma steroid
hormones and proinflammatory cytokines. J.Trace Elem. Med. Biol. 25, 54–58 (2011).
181. Newnham, R. E. Essentiality of boron for healthy bonesand joints. Environ. Health
Perspect. 102 Suppl 7, 83–85 (1994).
182. Naghii, M. R. & Samman, S. The e#ect of boronsupplementation on its urinary

excretion and selected cardiovascular riskfactors in healthy male subjects. Biol. Trace
Elem. Res. 56, 273–286 (1997).
183. Nielsen, F. H., Hunt, C. D., Mullen, L. M. & Hunt,J. R. E#ect of dietary boron on
mineral, estrogen, and testosterone metabolismin postmenopausal women. FASEB J. 1,
394–397 (1987).
184. Meena, H., Pandey, H. K., Arya, M. C. & Ahmed, Z.Shilajit: A panacea for high-
altitude problems. Int. J. Ayurveda Res. 1, 37–40(2010).
185. Agarwal, S. P., Khanna, R., Karmarkar, R., Anwer, M.K. & Khar, R. K. Shilajit: a review.
Phytother. Res. 21, 401–405 (2007).
186. Pandit, S. et al. Clinical evaluation of purified Shilajiton testosterone levels in

healthy volunteers. Andrologia 48, 570–575 (2016).
187. Biswas, T. K. et al. Clinical evaluation ofspermatogenic activity of processed

Shilajit in oligospermia. Andrologia 42,48–56 (2010).
188. Das, A. et al. The Human Skeletal Muscle Transcriptomein Response to Oral Shilajit
Supplementation. J. Med. Food 19, 701–709 (2016).
189. Burge, K., Gunasekaran, A., Eckert, J. & Chaaban,H. Curcumin and Intestinal
Inflammatory Diseases: Molecular Mechanisms ofProtection. Int. J. Mol. Sci. 20,
(2019).
190. Ng, Q. X. et al. A Meta-Analysis of the Clinical Useof Curcumin for Irritable Bowel
Syndrome (IBS). J. Clin. Med. Res. 7, (2018).
191. Ghosh, S. S., He, H., Wang, J., Gehr, T. W. &Ghosh, S. Curcumin-mediated regulation
of intestinal barrier function: Themechanism underlying its beneficial e#ects. Tissue
Barriers 6, e1425085(2018).
192. Peterson, C. T. et al. E#ects of Turmeric andCurcumin Dietary Supplementation on

Human Gut Microbiota: A Double-Blind,Randomized, Placebo-Controlled Pilot Study. J
Evid Based Integr Med 23,2515690X18790725 (2018).
193. Di Meo, F., Margarucci, S., Galderisi, U., Crispi, S.& Peluso, G. Curcumin, Gut
Microbiota, and Neuroprotection. Nutrients 11,(2019).
194. Hewlings, S. J. & Kalman, D. S. Curcumin: A Reviewof Its’ E#ects on Human Health.
Foods 6, (2017).
195. Soto-Urquieta, M. G. et al. Curcumin restoresmitochondrial functions and

decreases lipid peroxidation in liver and kidneysof diabetic db/db mice. Biol. Res. 47, 74
(2014).
196. Ahmad, A., Alghamdi, S. S., Mahmood, K. & Afzal,M. Fenugreek a multipurpose
crop: Potentialities and improvements. Saudi J.Biol. Sci. 23, 300–310 (2016).
197. Dawid-Pać, R. Medicinal plants used in treatment ofinflammatory skin diseases.

Postepy Dermatol Alergol 30, 170–177 (2013).
198. Steels, E., Rao, A. & Vite"a, L. Physiologicalaspects of male libido enhanced by
standardized Trigonella foenum-graecumextract and mineral formulation. Phytother.
Res. 25, 1294–1300 (2011).
199. Rao, A., Steels, E., Inder, W. J., Abraham, S. &Vite"a, L. Testofen, a specialised
Trigonella foenum-graecum seed extractreduces age-related symptoms of androgen
decrease, increases testosteronelevels and improves sexual function in healthy aging
males in a double-blindrandomised clinical study. Aging Male 19, 134–142 (2016).
200. Maheshwari, A. et al. E#icacy of FurosapTM, a novelTrigonella foenum-graecum

seed extract, in Enhancing Testosterone Level andImproving Sperm Profile in Male
Volunteers. Int. J. Med. Sci. 14, 58–66 (2017).
201. Wankhede, S., Mohan, V. & Thakurdesai, P.Beneficial e#ects of fenugreek

glycoside supplementation in male subjectsduring resistance training: A randomized
controlled pilot study. J Sport HealthSci 5, 176–182 (2016).
202. Rao, A., Steels, E., Beccaria, G., Inder, W. J. &Vite"a, L. Influence of a Specialized
Trigonella foenum-graecum Seed Extract(Libifem), on Testosterone, Estradiol and
Sexual Function in HealthyMenstruating Women, a Randomised Placebo Controlled
Study. Phytother. Res. 29,1123–1130 (2015).
203. Kassaian, N., Azadbakht, L., Forghani, B. & Amini,M. E#ect of fenugreek seeds on
blood glucose and lipid profiles in type 2diabetic patients. Int. J. Vitam. Nutr. Res. 79,
34–39 (2009).
204. Sharma, R. D., Raghuram, T. C. & Rao, N. S. E#ectof fenugreek seeds on blood
glucose and serum lipids in type I diabetes. Eur.J. Clin. Nutr. 44, 301–306 (1990).
205. Kiss, R. et al. Insulin-Sensitizer E#ects ofFenugreek Seeds in Parallel with

Changes in Plasma MCH Levels in Healthy Volunteers.Int. J. Mol. Sci. 19, (2018).
207. Bode, A. M. & Dong, Z. Chapter 7 The Amazing andMighty Ginger. Herbal Medicine:
Biomolecular and Clinical Aspects.
208. Mazidi, M., Gao, H.-K., Rezaie, P. & Ferns, G. A.The e#ect of ginger
supplementation on serum C-reactive protein, lipid profileand glycaemia: a systematic
review and meta-analysis. Food Nutr. Res. 60, 32613(2016).
209. Kanner, J., Harel, S. & Granit, R. Betalains–a newclass of dietary cationized
antioxidants. J. Agric. Food Chem. 49, 5178–5185(2001).
210. Cli#ord, T., Howatson, G., West, D. J. &Stevenson, E. J. The potential benefits of red
beetroot supplementation inhealth and disease. Nutrients 7, 2801–2822 (2015).
211. Bondonno, C. P., Croft, K. D. & Hodgson, J. M.Dietary Nitrate, Nitric Oxide, and
Cardiovascular Health. Crit. Rev. Food Sci.Nutr. 56, 2036–2052 (2016).
212. Bondonno, C. P. et al. Vegetable-derived bioactivenitrate and cardiovascular

health. Mol. Aspects Med. 61, 83–91 (2018).
213. Vanderpool, R. & Gladwin, M. T. Harnessing thenitrate-nitrite-nitric oxide pathway

for therapy of heart failure withpreserved ejection fraction. Circulation vol. 131 334–
336 (2015).
214. USDA Database for the Oxygen Radical AbsorbanceCapacity (ORAC) of Selected
Foods, Release 2.
215. Lichtenthäler, R. et al. Total oxidant scavenging capacitiesof Euterpe oleracea

Mart. (Açaí) fruits. Int. J. Food Sci. Nutr. 56, 53–64(2005).
216. Machado, A. K. et al. Neuroprotective E#ects of Açaí(Euterpe oleracea Mart.)

against Rotenone In Vitro Exposure. Oxid. Med. Cell.Longev. 2016, 8940850 (2016).
217. Feio, C. A. et al. Euterpe oleracea (açai) modifiessterol metabolism and a"enuates
experimentally-induced atherosclerosis. J.Atheroscler. Thromb. 19, 237–245 (2012).
218. de Souza, M. O. et al. The hypocholesterolemicactivity of açaí (Euterpe oleracea

Mart.) is mediated by the enhancedexpression of the ATP-binding casse"e, subfamily
G transporters 5 and 8 andlow-density lipoprotein receptor genes in the rat. Nutr. Res.
32, 976–984(2012).
219. de Souza, M. O., Silva, M., Silva, M. E., Oliveira, R.de P. & Pedrosa, M. L. Diet
supplementation with acai (Euterpe oleraceaMart.) pulp improves biomarkers of
oxidative stress and the serum lipid profilein rats. Nutrition 26, 804–810 (2010).
220. Poulose, S. M. et al. Restoration of stressor-inducedcalcium dysregulation and

autophagy inhibition by polyphenol-rich açaí (Euterpespp.) fruit pulp extracts in
rodent brain cells in vitro. Nutrition 30, 853–862(2014).
221. Poulose, S. M., Bielinski, D. F., Carey, A., Schauss,A. G. & Shuki"-Hale, B. Modulation
of oxidative stress, inflammation,autophagy and expression of Nrf2 in hippocampus
and frontal cortex of rats fedwith açaí-enriched diets. Nutr. Neurosci. 20, 305–315
(2017).
222. Poulose, S. M. et al. Anthocyanin-rich açai (Euterpeoleracea Mart.) fruit pulp

fractions a"enuate inflammatory stress signaling inmouse brain BV-2 microglial cells.
J. Agric. Food Chem. 60, 1084–1093 (2012).
223. Carey, A. N. et al. Dietary supplementation with thepolyphenol-rich açaí pulps

(Euterpe oleracea Mart. and Euterpe precatoriaMart.) improves cognition in aged rats
and a"enuates inflammatory signaling inBV-2 microglial cells. Nutr. Neurosci. 20, 238–
245 (2017).
224. Alessandra-Perini, J., Rodrigues-Baptista, K. C.,Machado, D. E., Nasciu"i, L. E. &

Perini, J. A. Anticancer potential,molecular mechanisms and toxicity of Euterpe
oleracea extract (açaí): Asystematic review. PLoS One 13, e0200101 (2018).
225. Sadowska-Krępa, E. et al. E#ects of supplementationwith acai (Euterpe oleracea

Mart.) berry-based juice blend on the bloodantioxidant defence capacity and lipid
profile in junior hurdlers. A pilotstudy. Biol. Sport 32, 161–168 (2015).
226. de Freitas Carvalho, M. M. et al. E#ects of açai onoxidative stress, ER stress, and
inflammation-related parameters in mice withhigh fat diet-fed induced NAFLD. Sci.
Rep. 9, 8107 (2019).
227. Udani, J. K., Singh, B. B., Singh, V. J. &Barre", M. L. E#ects of Açai (Euterpe oleracea
Mart.) berry preparation onmetabolic parameters in a healthy overweight population:
a pilot study. Nutr.J. 10, 45 (2011).
228. Solverson, P. M. et al. An Anthocyanin-RichMixed-Berry Intervention May Improve

Insulin Sensitivity in a Randomized Trialof Overweight and Obese Adults. Nutrients 11,
(2019).
229. Belwal, T., Nabavi, S. F., Nabavi, S. M. &Habtemariam, S. Dietary Anthocyanins and
Insulin Resistance: When Food Becomesa Medicine. Nutrients 9, (2017).
230. Burdulis, D., Ivanauskas, L., Dirse, V., Kazlauskas,S. & Razukas, A. Study of diversity
of anthocyanin composition in bilberry(Vaccinium myrtillus L.) fruits. Medicina 43, 971–
977 (2007).
231. Lä"i, A. K., Riihinen, K. R. & Kainulainen, P. S.Analysis of anthocyanin variation in

wild populations of bilberry (Vacciniummyrtillus L.) in Finland. J. Agric. Food Chem. 56,
190–196 (2008).
232. Colak, N. et al. Bog bilberry phenolics, antioxidantcapacity and nutrient profile.
Food Chem. 201, 339–349 (2016).
233. Chu, W.-K., Cheung, S. C. M., Lau, R. A. W. &Benzie, I. F. F. Bilberry (Vaccinium

myrtillus L.). in Herbal Medicine:Biomolecular and Clinical Aspects (eds. Benzie, I. F. F. &
Wachtel-Galor,S.) (CRC Press/Taylor & Francis, 2012).
234. Chan, S. W. & Tomlinson, B. E#ects of BilberrySupplementation on Metabolic and

Cardiovascular Disease Risk. Molecules 25,(2020).
235. Karlsen, A. et al. Anthocyanins inhibit nuclearfactor-kappaB activation in

monocytes and reduce plasma concentrations ofpro-inflammatory mediators in
healthy adults. J. Nutr. 137, 1951–1954 (2007).
236. Karlsen, A. et al. Bilberry juice modulates plasmaconcentration of NF-kappaB

related inflammatory markers in subjects atincreased risk of CVD. Eur. J. Nutr. 49, 345–
355 (2010).
237. Kolehmainen, M. et al. Bilberries reduce low-gradeinflammation in individuals with

features of metabolic syndrome. Mol. Nutr.Food Res. 56, 1501–1510 (2012).
238. Hoggard, N. et al. A single supplement of astandardised bilberry (Vaccinium

myrtillus L.) extract (36 % wet weightanthocyanins) modifies glycaemic response in
individuals with type 2 diabetescontrolled by diet and lifestyle. J. Nutr. Sci. 2, e22
(2013).
239. de Mello, V. D. et al. Fasting serum hippuric acid iselevated after bilberry
(Vaccinium myrtillus) consumption and associates withimprovement of fasting
glucose levels and insulin secretion in persons at highrisk of developing type 2
diabetes. Mol. Nutr. Food Res. 61, (2017).
240. Erlund, I. et al. Favorable e#ects of berryconsumption on platelet function, blood

pressure, and HDL cholesterol. Am. J.Clin. Nutr. 87, 323–331 (2008).
241. Qin, Y. et al. Anthocyanin supplementation improvesserum LDL- and HDL-

cholesterol concentrations associated with the inhibition ofcholesteryl ester transfer
protein in dyslipidemic subjects. Am. J. Clin. Nutr.90, 485–492 (2009).
242. Shim, S. H., Kim, J. M., Choi, C. Y., Kim, C. Y. &Park, K. H. Ginkgo biloba extract and
bilberry anthocyanins improve visualfunction in patients with normal tension
glaucoma. J. Med. Food 15, 818–823(2012).
243. Riva, A. et al. The e#ect of a natural, standardizedbilberry extract (Mirtoselect®)

in dry eye: a randomized, double blinded,placebo-controlled trial. Eur. Rev. Med.
Pharmacol. Sci. 21, 2518–2525 (2017).
244. Liang, T. & Others. E#ect of a Bilberry Extract(BILBERON®)—containing Diet on the

Improvement of Eye Fatigue—related Symptoms(Ⅱ)―A Randomized, Double—blind,
Placebo—controlled, Parallel—group ComparisonStudy―. 45, 1523–1534
(2017).
245. Ozawa, Y. et al. Bilberry extract supplementation forpreventing eye fatigue in

video display terminal workers. J. Nutr. Health Aging19, 548–554 (2015).
246. Kosehira, M., Machida, N. & Kitaichi, N. A12-Week-Long Intake of Bilberry Extract
(Vaccinium myrtillus L.) ImprovedObjective Findings of Ciliary Muscle Contraction of
the Eye: A Randomized,Double-Blind, Placebo-Controlled, Parallel-Group Comparison
Trial. Nutrients12, (2020).
247. Ooe, E. et al. Bilberry extract and anthocyaninssuppress unfolded protein

response induced by exposure to blue LED light ofcells in photoreceptor cell line. Mol.
Vis. 24, 621–632 (2018).
248. Quispe-Fuentes, I., Vega-Gálvez, A. & Aranda, M.Evaluation of phenolic profiles

and antioxidant capacity of maqui (Aristoteliachilensis) berries and their relationships
to drying methods. J. Sci. FoodAgric. 98, 4168–4176 (2018).
249. Davinelli, S., Bertoglio, J. C., Zarrelli, A., Pina,R. & Scapagnini, G. A Randomized
Clinical Trial Evaluating the E#icacy ofan Anthocyanin-Maqui Berry Extract
(Delphinol®) on Oxidative Stress Biomarkers.J. Am. Coll. Nutr. 34 Suppl 1, 28–33 (2015).
250. Schreckinger, M. E., Lo"on, J., Lila, M. A. & deMejia, E. G. Berries from South
America: a comprehensive review on chemistry,health potential, and
commercialization. J. Med. Food 13, 233–246 (2010).
251. Araya, H., Clavijo, C. & Herrera, C. [Antioxidantcapacity of fruits and vegetables
cultivated in Chile]. Arch. Latinoam. Nutr.56, 361–365 (2006).
252. Cespedes, C. L. et al. The chilean superfruitblack-berry Aristotelia chilensis

(Elaeocarpaceae), Maqui as mediator ininflammation-associated disorders. Food
Chem. Toxicol. 108, 438–450 (2017).
253. Watson, R. R. & Schönlau, F. Nutraceutical andantioxidant e#ects of a delphinidin-

rich maqui berry extract Delphinol®: areview. Minerva Cardioangiol. 63, 1–12 (2015).
254. Vergara, D. et al. The intake of maqui (Aristoteliachilensis) berry extract
normalizes H2O2 and IL-6 concentrations in exhaledbreath condensate from healthy

smokers – an explorative study. Nutr. J. 14, 27(2015).
255. Alvarado, J., Schoenlau, F., Leschot, A., Salgad, A.M. & Vigil Portales, P. Delphinol®
standardized maqui berry extractsignificantly lowers blood glucose and improves
blood lipid profile inprediabetic individuals in three-month clinical trial. Panminerva
Med. 58, 1–6(2016).
256. Hitoe, S., Tanaka, J. & Shimoda, H. MaquiBrightTMstandardized maqui berry

extract significantly increases tear fluid productionand ameliorates dry eye-related
symptoms in a clinical pilot trial. PanminervaMed. 56, 1–6 (2014).
257. Yamashita, S.-I., Suzuki, N., Yamamoto, K., Iio, S.-I.& Yamada, T. E#ects of
MaquiBright® on improving eye dryness and fatiguein humans: A randomized, double-
blind, placebo-controlled trial. Afr. J.Tradit. Complement. Altern. Med. 9, 172–178
(2019).
258. Heber, D. Pomegranate Ellagitannins. in HerbalMedicine: Biomolecular and Clinical

Aspects (eds. Benzie, I. F. F. &Wachtel-Galor, S.) (CRC Press/Taylor & Francis, 2012).
259. Ismail, T. et al. Ellagitannins in CancerChemoprevention and Therapy. Toxins 8,

(2016).
260. Aviram, M. et al. Pomegranate juice consumption for 3years by patients with
carotid artery stenosis reduces common carotidintima-media thickness, blood
pressure and LDL oxidation. Clin. Nutr. 23,423–433 (2004).
261. Davidson, M. H. et al. E#ects of consumption ofpomegranate juice on carotid

intima-media thickness in men and women atmoderate risk for coronary heart disease.
Am. J. Cardiol. 104, 936–942 (2009).
262. Basu, A., Newman, E. D., Bryant, A. L., Lyons, T. J.& Be"s, N. M. Pomegranate
polyphenols lower lipid peroxidation in adultswith type 2 diabetes but have no e#ects
in healthy volunteers: a pilot study.J. Nutr. Metab. 2013, 708381 (2013).
263. Aviram, M. et al. Pomegranate juice flavonoids inhibitlow-density lipoprotein

oxidation and cardiovascular diseases: studies inatherosclerotic mice and in humans.
Drugs Exp. Clin. Res. 28, 49–62 (2002).
264. Rosenblat, M., Volkova, N., A"ias, J., Mahamid, R.& Aviram, M. Consumption of
polyphenolic-rich beverages (mostly pomegranateand black currant juices) by healthy
subjects for a short term increased serumantioxidant status, and the serum’s ability to
a"enuate macrophage cholesterolaccumulation. Food Funct. 1, 99–109 (2010).
265. Zarfeshany, A., Asgary, S. & Javanmard, S. H.Potent health e#ects of

pomegranate. Adv. Biomed. Res. 3, 100 (2014).
266. Sharma, P., McClees, S. F. & Afaq, F. Pomegranatefor Prevention and Treatment of
Cancer: An Update. Molecules 22, (2017).
267. Pantuck, A. J. et al. Phase II study of pomegranatejuice for men with rising
prostate-specific antigen following surgery orradiation for prostate cancer. Clin.
Cancer Res. 12, 4018–4026 (2006).
268. Tan, S. et al. Pomegranate activates TFEB to promoteautophagy-lysosomal

fitness and mitophagy. Sci. Rep. 9, 727 (2019).
269. Ryu, D. et al. Urolithin A induces mitophagy andprolongs lifespan in C. elegans and
increases muscle function in rodents. Nat.Med. 22, 879–888 (2016).
270. Andreux, P. A. et al. The mitophagy activatorurolithin A is safe and induces a

molecular signature of improved mitochondrialand cellular health in humans. Nat
Metab 1, 595–603 (2019).
271. Tan, L. et al. Investigation on the Role of BDNF inthe Benefits of Blueberry Extracts
for the Improvement of Learning and Memoryin Alzheimer’s Disease Mouse Model. J.
Alzheimers. Dis. 56, 629–640 (2017).
272. Rendeiro, C. et al. Blueberry supplementation inducesspatial memory

improvements and region-specific regulation of hippocampal BDNFmRNA expression
in young rats. Psychopharmacology 223, 319–330 (2012).
273. Bensalem, J. et al. Polyphenol-rich extract from grapeand blueberry a"enuates

cognitive decline and improves neuronal function inaged mice. J. Nutr. Sci. 7, e19
(2018).
274. Winter, A. N. & Bickford, P. C. Anthocyanins andTheir Metabolites as Therapeutic

Agents for Neurodegenerative Disease.Antioxidants (Basel) 8, (2019).
275. Krikorian, R. et al. Blueberry supplementationimproves memory in older adults. J.

Agric. Food Chem. 58, 3996–4000 (2010).
276. Bowtell, J. L., Aboo-Bakkar, Z., Conway, M. E., Adlam,A.-L. R. & Fulford, J. Enhanced
task-related brain activation and restingperfusion in healthy older adults after chronic
blueberry supplementation.Appl. Physiol. Nutr. Metab. 42, 773–779 (2017).
277. Boespflug, E. L. et al. Enhanced neural activationwith blueberry supplementation

in mild cognitive impairment. Nutr. Neurosci.21, 297–305 (2018).
278. Whyte, A. R., Cheng, N., Fromentin, E. & Williams,C. M. A Randomized, Double-
Blinded, Placebo-Controlled Study to Compare the Safetyand E#icacy of Low Dose
Enhanced Wild Blueberry Powder and Wild BlueberryExtract (ThinkBlueTM) in
Maintenance of Episodic and Working Memory in OlderAdults. Nutrients 10, (2018).
279. Bergland, A. K. et al. E#ects of AnthocyaninSupplementation on Serum Lipids,

Glucose, Markers of Inflammation and Cognitionin Adults With Increased Risk of
Dementia – A Pilot Study. Front. Genet. 10,536 (2019).
280. Whyte, A. R., Cheng, N., Butler, L. T., Lamport, D. J.& Williams, C. M. Flavonoid-Rich
Mixed Berries Maintain and ImproveCognitive Function Over a 6 h Period in Young
Healthy Adults. Nutrients 11,(2019).
281. Kent, K., Charlton, K. E., Netzel, M. & Fanning,K. Food-based anthocyanin intake
and cognitive outcomes in human interventiontrials: a systematic review. J. Hum. Nutr.
Diet. 30, 260–274 (2017).
282. Ma, L., Sun, Z., Zeng, Y., Luo, M. & Yang, J.Molecular Mechanism and Health Role of
Functional Ingredients in Blueberry forChronic Disease in Human Beings. Int. J. Mol.
Sci. 19, (2018).
283. Jepson, R. G. & Craig, J. C. Cranberries forpreventing urinary tract infections.

Cochrane Database Syst. Rev. CD001321(2008).
284. Maki, K. C. et al. Consumption of a cranberry juicebeverage lowered the number of

clinical urinary tract infection episodes inwomen with a recent history of urinary tract
infection. Am. J. Clin. Nutr. 103,1434–1442 (2016).
285. Blumberg, J. B. et al. Cranberries and their bioactiveconstituents in human health.

Adv. Nutr. 4, 618–632 (2013).
286. Blumberg, J. B. et al. Impact of Cranberries on GutMicrobiota and Cardiometabolic

Health: Proceedings of the Cranberry HealthResearch Conference 2015. Adv. Nutr. 7,
759S–70S (2016).
287. Neto, C. C. & Vinson, J. A. Cranberry. in HerbalMedicine: Biomolecular and Clinical

Aspects (eds. Benzie, I. F. F. &Wachtel-Galor, S.) (CRC Press/Taylor & Francis, 2012).
288. Zhang, L. et al. E#icacy of cranberry juice onHelicobacter pylori infection: a

double-blind, randomized placebo-controlledtrial. Helicobacter 10, 139–145 (2005).
289. Go"eland, M. et al. Modulation of Helicobacter pyloricolonization with cranberry
juice and Lactobacillus johnsonii La1 in children.Nutrition 24, 421–426 (2008).
290. Ruel, G. et al. Favourable impact of low-caloriecranberry juice consumption on

plasma HDL-cholesterol concentrations in men.Br. J. Nutr. 96, 357–364 (2006).
291. Lee, I. T., Chan, Y. C., Lin, C. W., Lee, W. J. &Sheu, W. H.-H. E#ect of cranberry
extracts on lipid profiles in subjects withType 2 diabetes. Diabet. Med. 25, 1473–1477
(2008).
292. Ruel, G. et al. Low-calorie cranberry juicesupplementation reduces plasma

oxidized LDL and cell adhesion moleculeconcentrations in men. Br. J. Nutr. 99, 352–359
(2008).
293. Basu, A. et al. Low-energy cranberry juice decreaseslipid oxidation and increases
plasma antioxidant capacity in women withmetabolic syndrome. Nutr. Res. 31, 190–196
(2011).
294. Simão, T. N. C. et al. Reduced-energy cranberry juiceincreases folic acid and

adiponectin and reduces homocysteine and oxidativestress in patients with the
metabolic syndrome. Br. J. Nutr. 110, 1885–1894(2013).
295. Dohadwala, M. M. et al. E#ects of cranberry juiceconsumption on vascular

function in patients with coronary artery disease. Am.J. Clin. Nutr. 93, 934–940 (2011).
296. Denis, M.-C. et al. Prevention of oxidative stress,inflammation and mitochondrial

dysfunction in the intestine by di#erentcranberry phenolic fractions. Clin. Sci. 128,
197–212 (2015).
297. Caldas, A. P. S., Coelho, O. G. L. & Bressan, J.Cranberry antioxidant power on

oxidative stress, inflammation and mitochondrialdamage. Int. J. Food Prop. 21, 582–
592 (2018).
*These statements have not been evaluated by the Food and Drug Administration. This product is
not intended to diagnose, treat, cure, or prevent any disease.
Products Account Contact Us
Energenesis Create 249 S Highway 101 Suite

Energy Blueprint Labs Account 410, Solana Beach, CA
Energy
formulates market- 92075 California, USA
Essentials & My Account
leading, powerful,
Superfoods
evidence-backed
Orders [email protected]
UltraBrain
supplements for Lost
(858) 284-0643
energy, immunity and Immune Password
brain optimization. Genesis theenergyblueprint.com
Logout
Ultimate
! "
Energy
Bundle
All Products
TERMS OF SERVICE PRIVACY POLICY

Copyright © 2021 Ari Whi!en, Inc.
SHIPPING AND RETURNS

Energy Essentials & Superfoods - The Energy Blueprint Store

Uploaded by

Copyright:

Available Formats

Energy Essentials & Superfoods - The Energy Blueprint Store

Uploaded by

Document Information

Original Title

Copyright

Available Formats

Share this document

Share or Embed Document

Sharing Options

Did you find this document useful?

Is this content inappropriate?

Copyright:

Available Formats

Energy Essentials & Superfoods - The Energy Blueprint Store

Uploaded by

Copyright:

Available Formats

Energy Essentials & Superfoods – The Energy Blueprint Store 29/11/21, 15:37

HOME PRODUCTS CONTACT 1

Use Coupon Code THANKS2021!

NEW BATCH ARRIVING IN A FEW DAYS AND

ARE YOUR FATIGUE ISSUES CAUSED BY

Did you know that your body REQUIRES over 30 di!erent

SO WHAT DO YOU NEED TO DO?

BACK TO THE PROBLEM...

THERE ARE 3 MAJOR REASONS WHY

Today, that’s just not possible.

GET YOUR ENERGY

" ADD TO CART " ADD TO CART

NEW BATCH ARRIVING IN A FEW DAYS AND

Worldwide Shipping (FREE Shipping within the U.S.)*

Beta-carotene can be converted by

Retinol is involved in regulating the

we have provided most of one’s daily

The B-complex vitamins include 8

Thiamine (B1) is required to

Niacin (B3) is the central unit for

amino acid metabolism, gene

While all B-vitamin jobs are important,

Elevated levels of homocysteine is a

major risk factor for cardiovascular

Ensuring ample B-vitamin intake and

Benfotiamine is a special fat-soluble

cells.17 Bioavailability studies have

Benfotiamine works to protect the

Through these mechanisms, research

In healthy smokers, 1050 mg/d

In type 2 diabetes, 1050 mg/d

Riboflavin is critical for numerous

The mutation makes it more di#icult

In other words, this mutation only

Although the dietary reference intake

A meta-analysis of 14 studies found

It’s also worth noting that riboflavin

Niacinamide is a direct precurser to

Pantesin (pantethine) is a form of

Pyridoxal 5’ Phosphate (P5P) is the

Biotin (also known as vitamin H) is a

A notable percentage of the

Supplementing metafolin (5-methyl

Trimethylglycine (TMG; also known as

Vitamin D is a unique nutrient

But things are a lot di#erent today

than they were 100, let alone 1 million

Adding a li"le vitamin D into the diet

Numerous meta-analyses have also

Vitamin E is not one single chemical

Gamma-tocopherol and delta-

Studies in humans suggest that

The Metabolic minerals blend provides

larger amino acid structures,

metabolism of amino acids, DNA

Our formula also contains the wonder

Improve mitochondrial health

metals and other pollutants.