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Multiple Choice Questions: 1. Glycolysis

The document contains 17 multiple choice questions testing knowledge of glycolysis and fermentation. Glycolysis is the metabolic pathway that converts glucose to pyruvate with production of ATP and NADH. Under anaerobic conditions, pyruvate is further metabolized via fermentation to regenerate NAD+ and allow glycolysis to continue. In muscle pyruvate is reduced to lactate, while in yeast it is decarboxylated and reduced to ethanol. The questions cover the key steps, products, and cofactors involved in these processes.

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829 views

Multiple Choice Questions: 1. Glycolysis

The document contains 17 multiple choice questions testing knowledge of glycolysis and fermentation. Glycolysis is the metabolic pathway that converts glucose to pyruvate with production of ATP and NADH. Under anaerobic conditions, pyruvate is further metabolized via fermentation to regenerate NAD+ and allow glycolysis to continue. In muscle pyruvate is reduced to lactate, while in yeast it is decarboxylated and reduced to ethanol. The questions cover the key steps, products, and cofactors involved in these processes.

Uploaded by

Nguyễn Tân
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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Multiple Choice Questions

1. Glycolysis
Glycolysis is the name given to a metabolic pathway occurring in many different cell types. It
consists of 11 enzymatic steps that convert glucose to lactic acid. Glycolysis is an example of:

A) aerobic metabolism.
B) anabolic metabolism.
C) a net reductive process.
D) fermentation.
E) oxidative phosphorylation.

2. Glycolysis
The anaerobic conversion of 1 mol of glucose to 2 mol of lactate by fermentation is accompanied by a
net gain of:

A) 1 mol of ATP.
B) 1 mol of NADH.
C) 2 mol of ATP.
D) 2 mol of NADH.
E) none of the above.

3. Fates of pyruvate under anaerobic conditions: fermentation


During strenuous exercise, the NADH formed in the glyceraldehyde 3-phosphate dehydrogenase
reaction in skeletal muscle must be reoxidized to NAD+ if glycolysis is to continue. The most
important reaction involved in the reoxidation of NADH is:

A) dihydroxyacetone phosphate  glycerol 3-phosphate


B) glucose 6-phosphate  fructose 6-phosphate
C) isocitrate  -ketoglutarate
D) oxaloacetate  malate
E) pyruvate  lactate

4. Fates of pyruvate under anaerobic conditions: fermentation


If glucose labeled with 14C in C-1 were fed to yeast carrying out the ethanol fermentation, where
would the 14C label be in the products?

A) In C-1 of ethanol and CO2


B) In C-1 of ethanol only
C) In C-2 (methyl group) of ethanol only
D) In C-2 of ethanol and CO2
E) In CO2 only

The conversion of 1 mol of fructose 1,6-bisphosphate to 2 mol of pyruvate by the glycolytic pathway
results in a net formation of:

A) 1 mol of NAD+ and 2 mol of ATP.


B) 1 mol of NADH and 1 mol of ATP.
C) 2 mol of NAD+ and 4 mol of ATP.
D) 2 mol of NADH and 2 mol of ATP.
E) 2 mol of NADH and 4 mol of ATP.
158 Chapter 14 Glycolysis, Gluconeogenesis, and the Pentose Phosphate Pathway
5. Fates of pyruvate under anaerobic conditions: fermentation
In an anaerobic muscle preparation, lactate formed from glucose labeled in C-3 and C-4 would be
labeled in:

A) all three carbon atoms.


B) only the carbon atom carrying the OH.
C) only the carboxyl carbon atom.
D) only the methyl carbon atom.
E) the methyl and carboxyl carbon atoms.

6. Glycolysis
Which of the following statements is not true concerning glycolysis in anaerobic muscle?
A) Fructose 1,6-bisphosphatase is one of the enzymes of the pathway.
B) It is an endergonic process.
C) It results in net synthesis of ATP.
D) It results in synthesis of NADH.
E) Its rate is slowed by a high [ATP]/[ADP] ratio.

7. Glycolysis
Glucose labeled with 14C in C-1 and C-6 gives rise in glycolysis to pyruvate labeled in:
A) A and C.
B) all three carbons.
C) its carbonyl carbon.
D) its carboxyl carbon.
E) its methyl carbon.

8. Fates of pyruvate under anaerobic conditions: fermentation


In an anaerobic muscle preparation, lactate formed from glucose labeled in C-2 would be labeled in:
A) all three carbon atoms.
B) only the carbon atom carrying the OH.
C) only the carboxyl carbon atom.
D) only the methyl carbon atom.
E) the methyl and carboxyl carbon atoms.

9. Fates of pyruvate under anaerobic conditions: fermentation


If glucose labeled with 14C in C-3 is metabolized to lactate via fermentation, the lactate will contain
14
C in:
A) all three carbon atoms.
B) only the carbon atom carrying the OH.
C) only the carboxyl carbon atom.
D) only the methyl carbon atom.
E) the methyl and carboxyl carbon atoms.

10. Fates of pyruvate under anaerobic conditions: fermentation


Which of these cofactors participates directly in most of the oxidation-reduction reactions in the
fermentation of glucose to lactate?
A) ADP
B) ATP
C) FAD/FADH2
D) Glyceraldehyde 3-phosphate
E) NAD+/NADH
Chapter 14 Glycolysis, Gluconeogenesis, and the Pentose Phosphate Pathway 159
11. Fates of pyruvate under anaerobic conditions: fermentation
In comparison with the resting state, actively contracting human muscle tissue has a:

A) higher concentration of ATP.


B) higher rate of lactate formation.
C) lower consumption of glucose.
D) lower rate of consumption of oxygen
E) lower ratio of NADH to NAD+.

12. Glycolysis
The steps of glycolysis between glyceraldehyde 3-phosphate and 3-phosphoglycerate involve all of
the following except:

A) ATP synthesis.
B) catalysis by phosphoglycerate kinase.
C) oxidation of NADH to NAD+.
D) the formation of 1,3-bisphosphoglycerate.
E) utilization of Pi.

13. Glycolysis
Which of the following is a cofactor in the reaction catalyzed by glyceraldehyde 3-phosphate
dehydrogenase?

A) ATP
2+
B) Cu
C) heme
+
D) NAD
+
E) NADP

14. Feeder pathways for glycolysis


Page: 543 Difficulty: 1 Ans: C
Glycogen is converted to monosaccharide units by:

A) glucokinase.
B) glucose-6-phosphatase
C) glycogen phosphorylase.
D) glycogen synthase.
E) glycogenase.

15. Fates of pyruvate under anaerobic conditions: fermentation


Which of the following statements is incorrect?

A) Aerobically, oxidative decarboxylation of pyruvate forms acetate that enters the citric acid cycle.
B) In anaerobic muscle, pyruvate is converted to lactate.
C) In yeast growing anaerobically, pyruvate is converted to ethanol.
D) Reduction of pyruvate to lactate regenerates a cofactor essential for glycolysis.
E) Under anaerobic conditions pyruvate does not form because glycolysis does not occur.

16. Fates of pyruvate under anaerobic conditions: fermentation


The ultimate electron acceptor in the fermentation of glucose to ethanol is:

A) acetaldehyde.
160 Chapter 14 Glycolysis, Gluconeogenesis, and the Pentose Phosphate Pathway
B) acetate.
C) ethanol.
D) NAD+.
E) pyruvate.

17. Fates of pyruvate under anaerobic conditions: fermentation


In the alcoholic fermentation of glucose by yeast, thiamine pyrophosphate is a coenzyme required by:

A) aldolase.
B) hexokinase.
C) lactate dehydrogenase.
D) pyruvate decarboxylase.
E) transaldolase.

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