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Dukewriting Lesson2

The document provides principles and examples for revising sentences for clarity. The principles are to put new information last, use passive voice judiciously, and ensure the first and last sentences of a paragraph match. Exercises are then given to apply these principles, revising sentences about data clustering, gene targeting, transcriptional units, predictive power of alignments, morphological evolution, and enhancer activities.

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55 views1 page

Dukewriting Lesson2

The document provides principles and examples for revising sentences for clarity. The principles are to put new information last, use passive voice judiciously, and ensure the first and last sentences of a paragraph match. Exercises are then given to apply these principles, revising sentences about data clustering, gene targeting, transcriptional units, predictive power of alignments, morphological evolution, and enhancer activities.

Uploaded by

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Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Worksheet - Lesson 2: Cohesion, Coherence, and Emphasis

Principles:
1. Put new information last
2. Use passive voice judiciously
3. Make sure the first and last sentences of a paragraph match

Exercises (revise these sentences for clarity using the principles of this lesson):

1. These data were then subjected to hierarchical clustering using the Pearson correlation as the distance
metric.
Answer: we subjected the data to hierarchical clustering using the Pearson correlation as the distance
metric.
2. We designated the putative GRB target genes as the human TFs that were under a HCNE density peak and
whose orthologs were in conserved synteny with an array of HCNEs in human:zebrafish alignments.
Density peaks and syntenic regions were downloaded from the Ancora Genome Browser.

Answer: Browser to designate the putative GRB target genes as the human TFs that were under a HCNE
density peak and whose orthologs were in conserved synteny with an array of HCNEs in human:
zebrafish alignments.

3. By analyzing all of the available mouse cDNA sequences, it was found that the mouse genome encodes at
least 44 000 distinct transcriptional units; a transcriptional unit comprises all the RNAs that share a common
exonic sequence transcribed from the same genomic strand.

Answer: Transcriptional units comprise all the RNAs that share a common exonic sequence transcribed
from the same genomic strand; by analyzing all of the available mouse cDNA sequences it was found that
their genome encodes at least 44,000 different transcriptional units.

4. Improvements are expected in the predictive power of all the scores being computed on multispecies
alignments.

Answer: We expect improvements in the predictive power of computing all scores on multispecies
alignments.

5. With the development of molecular embryology and the coming of the post-genomic era, the molecular
mechanisms of morphological evolution have recently begun to be elucidated.

Answer: The molecular mechanisms of morphological evolution have recently begun to be elucidated with
the development of molecular embryology and the coming of the post-genomic era.

6. To assess the degree of enrichment of enhancer activities in predicted tissues, we compared the relative
frequency of enhancers for each of the three tissues examined here with a background set of 528 previously
tested sequences predicted to be developmental enhancers on the basis of extreme sequence constraint that
were not associated with a prior tissue specificity prediction.

Answer: We compare the relative frequency of enhancers to assess their activities in predicted tissues.
Previously tested sequences predicted to be developmental enhancers for each of the three tissues examined
with a background set of 528 despite extreme sequence constraint and unrelated to a prior tissue specificity
prediction.

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