M88-525

Introduction to Biostatistics

Fall 2015

Syllabus

Instructor Teaching Assistant

Michael Elliott, Ph.D., MS none

Assistant Professor

Room 478
Salus Center
Phone: 314-977-4027
E-mail: [email protected]

Office Hours
by appointment
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Syllabus, Fall 2015

Course Overview
Introduction: This course introduces the basic principles and methods of biostatistics,
providing students a sound methodological foundation for public health practice.

Purpose: The purpose of the course is to teach fundamental concepts and techniques of
descriptive and inferential statistics with applications in health care, medicine, public health, and
epidemiology. Basic statistics, including probability, descriptive statistics, inference for means
and proportions, and regression methods are presented. The analytic methods and applications
will be linked to topics including health promotion, epidemiology, and program evaluation.

Competencies to Assessments:
Competencies Associated learning Assessment of Learning
objective Objectives
Describe the approaches to a. Distinguish between  Quizzes
disease prevention and numerical and categorical  Weekly assignments
control using tools from the data, including which  In-class presentation of
five core areas of public methods to use for each public health research
health: behavioral science, b. Know the appropriate  Midterm and final exams
biostatistics, environmental application and limitations
health, epidemiology, and of hypothesis tests and
health management and regression methods
policy

Appropriately utilize qualitative a. Choose an appropriate  Quizzes

and quantitative data in order graphical or tabular  Weekly assignments
to effectively address public display for a given data  In-class presentation of
health problems set and question public health research
b. Determine which basic  Midterm and final exams
statistical method(s) is/are
most appropriate to
analyze the data at hand
c. Analyze data using
fundamental statistical
methods

MPH 6: Use an evidence- a. Draw conclusions from  Weekly assignments

based approach for the statistical analyses and  In-class presentation of
development of public health place them into the public health research
programs and policies appropriate public health  Midterm and final exams
context
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Syllabus, Fall 2015

Course Description

Course Format: The class format includes lectures, computer exercises, practical problems, and
teamwork. The various formats of the quizzes and assignments are chosen to:
1. Provide regular feedback
2. Require repetition of core techniques necessary for mastery of statistical thinking and
analysis
3. Challenge students to tackle both straightforward and difficult applications of
descriptive and analytic statistics to practical public health problems
4. Incorporate statistical tools and results into oral and written presentation, emphasizing
proper use of language and effective communication.

Course Elements and Requirements:

Texts: There is 1 text required for this class:
Author(s): TRIOLA & TRIOLA
Title: BIOSTATISTICS FOR THE BIOLOGICAL AND HEALTH SCIENCES.
ISBN: 9780321194367

Software: SPSS 23.0 is available on student computers in the College for Public Health and
Social Justice as well as in student computing labs on campus. You may rent it from e-Academy
via the e-store at OnTheHub. (http://www.onthehub.com/). Make sure to get the Standard
version, not the Base. You may rent either a 6 month or 12 month version. Older versions of
SPSS will also work for this class.
 https://estore.onthehub.com/WebStore/OfferingsOfMajorVersionList.aspx?pmv=89cf975
c-47c3-e411-940a-b8ca3a5db7a1&cmi_mnuMain=ed6ad73c-7bc7-e011-ae14-
f04da23e67f6

In addition to the text and access to SPSS a basic calculator will be useful for some classes. The
calculator function on a cell phone will suffice.

Grading Determination and Policy:

The final grades are: A (>92 to 100 points), A- (>90 to 91) B+ (>87 to 89 points), B (>82 to 86
points), B- (>80 to 81 points), C+ (>77 to 79 points), C (>72 to 76) C- (>70 to 71) and F (<70
points). Final grades will not be rounded.

For this class the final grade will be computed using the following scale:
Assignments – 20%
 Due by 4:30 p.m. day of next class period. Assignments are graded 0-non-turned in, 1-
incomplete, 2-complete.
Quizzes – 20%
 Quiz most every day of lecture covering the previous lecture
Labs 1-3 – 30% (10% each)
 Refer to handout on labs for instructions on formatting. Points will be deducted for late
labs and labs that are not properly formatted.
 Labs must be done with a partner.
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Syllabus, Fall 2015
 Grade will be reduced by 20 points for every 24 hours past due
Final – 20%
 Comprised of SPSS portion and written portion
 Entire final must be done individually
 Grade will be reduced by 20 points for every 24 hours past due
Presentation – 5%
 Done with partners
 Details TBA
Participation & Teamwork – 5%

All assignments and labs are to be completed on time unless other arrangements have been made
with the instructor at least one week in advance of due date, no late assignments will be
accepted. Students will be allowed to “retake” missed items on quizzes and receive half of the
missed points added to their grade for the quiz.

Feedback on Assignments: Timely feedback on assignments is needed in order to assure that

students are aware of their progress. For routine assignments, quizzes, presentations, and exams
feedback will be provided within two weeks after the due date. For longer assignments such as
labs, feedback will be provided within three weeks after the due date of the assignment. In the
rare event that these deadlines cannot be met, students should be informed of the delay and the
extra time needed in providing feedback.
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Syllabus, Fall 2015
Course Calendar

Date Topic Learning Read Assignments due

Objective
Part I: Descriptive Statistics
Week 1 Looking at your data 3a, 5b, 5c, Triola In class competency
 Types of Data 6a  Ch 1.1-1.2 quiz
 Tables & Graphs  Ch 2
 Central tendency &
dispersion
Week 2 Lab 1 3a, 5a, 6a SPSS videos Quiz 1
posted on HW 1
Blackboard

Week 3 Probability 5b, 5c Handout: Lab 1

 Bayes Theorem  Cartoon
 Sensitivity & Guide
Specificity Triola
 Odds Ratio &  Ch 3
Relative Risk

Week 4 Distributions 5b, 5c Triola Quiz 2

 Binomial distribution  Ch 4.1-4.4 HW 2
 Poisson distribution  Ch 5.1 –
 Normal distribution 5.6
 Central Limit
Theorem
 Standard scores/z-
scores
Part II: Inferential Statistics
Week 5 Statistical inference: 3b, 5a, 5b, Triola Quiz 3
 Samples and 5c, 6a  Ch 6.2 HW 3
populations  Ch 7.1-7.2
 Power
 Confidence intervals
 p-values
 Type I & II error
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Syllabus, Fall 2015
Date Topic Learning Read Assignments due
Objective
Week 6 One and two groups 3b, 5a, 5b, Triola Quiz 4
(continuous outcomes): 5c, 6a  Ch 6.3-6.4 HW 4
 One-sample  Ch. 7.3-7.5
population mean  Ch 8.1-8.4
 Paired sample t-test
 Independent samples
t-test
Week 7 Lab 2 3b, 5a, 5b, SPSS videos Quiz 5
5c, 6a posted on HW 5
Blackboard

Week 8 Comparing more than 3b, 5a, 5b, Triola Lab 2

two groups (continuous 5c, 6a  Ch 11
outcomes):
 One-way ANOVA
 Two-way ANOVA
Week 9 Comparing two groups 3b, 5a, 5b, Triola Quiz 6
(categorical outcomes): 5c, 6a  Ch 10 HW 6
 Chi-square test
 McNemar’s test
 Odds ratio
 Relative risk

Week 10  Correlation 3b, 5a, 5b, Triola Quiz 7

 Linear Regression 5c, 6a  Ch 9 HW 7

Week 11 Multiple predictor 3b, 5a, 5b, Quiz 8

variables 5c, 6a HW 8
 Multiple regression
 Logistic regression
Week 12 Lab 3 3b, 5a, 5b, Field - Quiz 9
5c, 6a Recommended HW 9
 Ch 11
 Ch 18
 Ch 7
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Syllabus, Fall 2015
Date Topic Learning Read Assignments due
Objective
Week 13 Non-parametric Tests 3b, 5a, 5b, Triola Lab 3
 Sign test 5c, 6a  Ch 12
 Wilcoxon test
 Kruskal-Wallis test
 Rank correlation

Week 14  Presentations 3b, 5a, 5b,

 Wrap-up and Review 5c, 6a
 Take home SPSS
section of Final
handed out

Week 15 Final Take home SPSS

 In class section section of final due
 In class competency 4:30 pm.
quiz
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Syllabus, Fall 2015
Labs - handout

All Labs must be conducted and formatted in the manner stated within this handout in
order to receive full credit.

Analysis for labs (except for the final lab) may be done with a partner. This allows you to
practice discussing statistical concepts with others. If you decide to work with a partner, please
email me your names. Then I can set your team up in Blackboard. One lab write up is due for
the pair. Each partner will receive the same grade on the lab.

All labs are required to include annotated SPSS syntax attached to the end of the write-up. We
will cover what annotated syntax is during the first lab.

The write up must be typed, single space in 12 point font with 1 inch margins. Answers must be
numbered and written in complete sentences. Pages must be numbered with your last names at
the top of each page.

Whether implicitly stated or not, all statistical tests must include your null hypothesis, alternative
hypothesis, results, and conclusions. In your results please give the test statistic, critical value,
and exact p-values calculated. Example: A statistical difference in BMI between drug groups
was found (F = 4.25, p = 0.016).

DO NOT include SPSS output directly. Rather create your own tables with the necessary results.
Your table must meet the definition of a “good” table as described on day 1. This means title at
the top and minimizing lines within the table. Figures may be copied and pasted directly from
SPSS. Please bear in mind that they will be printed in black and white for grading. They must
also include an appropriate title.