Cognitive Disorders
Cognitive Disorders
Cortical Dementia
Subcortical Dementia
Alzheimer’s Disease
Vascular Dementia
Pick’s Disease
▪ Pick's Disease is the result of a build-up of protein in the
frontal and temporal lobes of the brain.
▪ The accumulation of abnormal brain cells, known as Pick's
bodies, eventually leads to changes in character, socially
inappropriate behavior, and poor decision making,
progressing to a severe impairment in intellect, memory
and speech.
Creutzfeldt-Jakob Disease
▪ prion disease
▪ which means that healthy brain tissue deteriorates into an
abnormal protein that the body cannot break down.
▪ CJD is a type of transmissible spongiform
encephalopathy (TSE).
Huntington’s Disease
▪ destroying cells in the basal ganglia
▪ Caused by a gene mutation that leads to a toxic accumulation
of protein in the brain
▪ inherited from either one or both parents.
▪ Symptoms in early stages
▪ poor memory
▪ difficulty making decisions
▪ mood changes such as increased depression, anger or irritability
▪ growing lack of coordination, twitching or other uncontrolled
movements
▪ difficulty walking, speaking, and/or swallowing.
HIV Dementia
▪ AIDS dementia complex (ADC)
▪ a complicated syndrome made up of different nervous system and mental
symptoms. It is characterized by cognitive deficits such as inattentiveness,
impaired concentration and problem solving, forgetfulness, and impaired
reading, motor abnormalities such as tremors, slurred speech, ataxia, and
generalized hyperreflexia; and behavioral changes such as sluggishness and
social withdrawal.
Parkinson’s Disease
Dementia caused by head trauma
Amnesia
▪ memory impairment
Aphasia
▪ language disturbance
Apraxia
▪ unable to perform motor activities
Agnosia
▪ difficulty in identifying objects
Psychological Tests
Neurological Tests
▪ Electroencephalograph (EEG)
▪ Computerized Axial Tomography (CAT)
▪ Positron Emission Tomography (PET)
▪ Cerebral Blood Flow
▪ Magnetic Resonance Imaging (MRI)
Mental Status Exam
Physical Status Exam
Laboratory tests targeted at identifying general medical and
substance-related causes
Level of consciousness – not affected
Thought processes is impaired
Mental function is lost, relatively consistently for all
functions
Memory is lost, especially for recent events
Use of language - sometimes has difficulty finding the right
word
Mood is usually depressed and anxious in early stage, labile
mood, restless pacing, angry out-bursts in later stage.
Self-concept is usually angry or frustrated
Often experiences disturbed sleep-wake cycles.
Has at least one of the 4 A’s
Risk for injury
Disturbed sleep pattern
Risk for deficient fluid volume
Risk for imbalanced nutrition: less than body
requirements
Chronic confusion
Impaired environmental interpretation syndrome
Impaired memory
Impaired social interaction
Impaired verbal communication
Ineffective role performance
The client will be free from injury
The client will maintain an adequate balance of
activity and rest, nutrition, hydration, and elimination
The client will function as indepently as possible given
his or her limitations
The client will feel respected and supported
The client will remain involved in his or her
surroundings
The client will interact with others in the environment
Promote client’s safety
▪ Offer unobtrussive assistance with or supervision of activities
▪ Identify environmental triggers to help client avoid them
Promote adequate sleep and proper nutrition,
hygiene and activity
▪ Sit with client while eating
▪ Monitor bowel elimination pattern
▪ Remind client to urinate
▪ Encourage mild physical activities
Structure the environment and routine
▪ Encourage client to follow regular routines and habits
▪ Monitor environmental stumulation, and adjust when needed
Provide emotional support
▪ Be kind, respectful, calm, and reassuring, pay attention to client
▪ Use supportive touch when necessary
Promote interaction and involvement (Milieu management)
▪ Plan activities according to client’s interest and abilities
▪ Allow the client to have familiar objects around him/her
▪ reality orientation, self-worth, dignity
▪ Reminisce with client about the past
▪ Be alert to nonverbal cues
▪ Employ techniques of distraction
Provide a list of community resources, support groups, …
Presenting reality & attention to the emotional response
▪ dementia is a primary brain pathology.
▪ It is a long term care
Comparing Delirium and Dementia
Feature Delirium Dementia
Development Sudden Slow
Duration Days to weeks Months to years
Presence of other disorders Almost always present; may be a Possibly none
or physical problems severe illness, drug use or
withdrawal, or a problem with
metabolism
Variation at night Almost always worse Often worse
Attention Greatly impaired Maintained until late stages
Level of consciousness Fluctuates from lethargy to Normal until late stages
agitation
Orientation to surroundings Varies Impaired
Use of language Slow, often incoherent, and Sometimes difficulty finding the
inappropriate right word
Memory Jumbled and confused Lost, especially for recent events
Mental function Lost, variably and unpredictably Lost, relatively consistently for
all functions
Cause Usually an acute illness or drugs; Usually Alzheimer's disease,
in older people, usually infection, vascular dementia
dehydration, or drugs
Need for treatment Emergency medical attention Nonemergency medical attention
An irreversible form of senile dementia from a
nerve cell deterioration
Most common & most important
degenerative disease of the brain
characterized by cortical atrophy
and loss of neurons, particularly in
the parietal and temporal lobes
(starts at hippocampus) resulting to
intellectual deterioration
leads to nerve cell death
and tissue loss throughout
the brain. Over time, the
brain shrinks dramatically,
affecting nearly all its
functions.
Plaque
formation
Nerve
Tangles
STAGE 1
Preclinical Alzheimer’s Disease
STAGE 2
Mild Alzheimer’s Disease
STAGE 3
Moderate Alzheimer’s Disease
STAGE 4
Severe Alzheimer’s Disease
STAGE 1: Preclinical Alzheimer’s Disease
It begins near the hippocampus and the affected
region starts to shrink and in time
(10-20 years perhaps) lead to memory loss.
Rigidity (muscle
stiffness)
Loss of normal postural
reflexes – involuntary
flexion of the head &
neck = stooped posture
Pathognomonic gait :
Walking with slow, short,
shuffling steps, arms
flexed, abducted and
held stiffly at the sides
Characteristic appearance : Wide – eyed,
unblinking, staring expression with almost
immobile facial muscles, drooling of saliva
from slightly open mouth
Autonomic symptoms :
Diaphoresis,
orthostatic
hypotension, gastric
retention, constipation,
urinary retention
Leading cause of
death: Pneumonia
Neuropsychiatric and cognitive:
▪ Depression
▪ Anxiety
▪ Psychosis
▪ Dementia
▪ Apathy
▪ Fatigue
▪ Sleep disturbance
Based on Hx & PE
Causes of Secondary Parkinsonism are first
excluded
No specific diagnostic tests are available
Identify and assess nonmotor symptoms in patients with Parkinson's disease.
Discuss the impact of these symptoms on patients with PD.
Offer treatment strategies to improve nonmotor symptoms.
Impaired Physical Mobility r/t neuromuscular impairment
Risk for falls r/t decreased lower extremity strength and
orthosthatic hypotention
Risk for self-care deficit r/t neuromucular impairement
Risk for impaired verbal communication r/t physiologic
conditions
Chronic confusion r/t dementia
Risk for imbalanced nutrition: Less than ody requirements
r/t inability to ingest food due to biologic factors
Observe the patient's mood, cognition; organization and general well
being
Observe for features of depression esp. any suicidal ideas
If the patient is unresponsive or intolerant to pharmacotherapy, Electro
convulsive therapy is indicated.
In dementia, environmental modification is followed.
Avoid frequent change in the environment to minimise confusion if the
memory deficit is very severe
Sedatives are used if sleep related problems are noticed, when sleep
hygiene is unsuccessfully.
Patients should not be forced into situations in which they feel ashamed of
their appearance.
Encourage the patient to participate in moderate exercises, free-moving
sports like swimming
Sensory, rhythmic and other cues are used to keep the bradykinetic patients
moving.
Instruct the patients to speak slowly and clearly, and to pause and take a keep
breath at appropriate levels.
Advise the patient to organize thoughts before speaking
alternative methods like communication board, mechanical voice
synthesizer, computer or electronic typewriter are advised.
Patients are taught how to initiate raising from a chair by placing their hands
on the arms of the chair.
Patient's responses in the early stage of the disease process often are anxiety,
depression or panic
Relaxation
Supportive individual psychotherapy to both patients and caregivers
minimises distress.
Caregivers are educated to avoid misinterpretation and misconception about
the symptoms and expression of the patient and to respond, appropriately to
the symptoms and problems.
Family education and support are vital components as all members benefit
from knowledge about course and prognosis, as well as needing assistance
when assuming new roles in their relationship with the patients.
Drugs : Dopaminergic drugs
such as Levodopa
Better prognosis d/t Levodopa
but the disease still shortens life
Dopamine agonists
Def: Alteration or disturbance of mood.
Onset: recent
Duration :variable
Alertness: diminished ability to communicate
Orientation: “Don’t know answers”
Affect: Flat
Feature Organic Dementia Depression
Onset Slow Rapid
PRIMARY SECONDARY