Material Safety Data Sheet

2,3,3,3-Tetrafluoroprop-1-ene, HFO-1234yf

Version 1 Revision Date 09/28/2010 Print Date 10/18/2010

SECTION 1. PRODUCT AND COMPANY IDENTIFICATION

Product name : 2,3,3,3-Tetrafluoroprop-1-ene, HFO-1234yf

MSDS Number : 000000011078
Product Use Description : For R&D use only. Not for pharmaceutical, household or other
uses.

Company : Honeywell International, Inc.

101 Columbia Road
Morristown, NJ 07962-1057

For more information call : 800-522-8001

(Monday-Friday, 9:00am-5:00pm)

In case of emergency call : Medical: 1-800-498-5701 or +1-651-523-0309

: Transportation: 1-800-424-9300 or +1-703-527-3887
: (24 hours/day, 7 days/week)

SECTION 2. HAZARDS IDENTIFICATION

Emergency Overview

Form : Liquefied gas

Color : clear

Odor : slight

Hazard Summary : Warning! Container under pressure. Flammable gas. Gas

reduces oxygen available for breathing. Causes asphyxiation
in high concentrations. The victim will not realize that he/she is
suffocating. Inhalation may cause central nervous system
effects. May cause drowsiness and dizziness. May cause skin
irritation. May cause eye irritation. May cause respiratory tract
irritation. Do not breathe vapour. Avoid contact with skin, eyes
and clothing. At higher temperatures, (>250 C), decomposition
products may include hydrofluoric acid (HF) and carbonyl
halides. The ACGIH Threshold Limit Values (2007) for
Hydrogen Fluoride are TLV-TWA 0.5 ppm and Ceiling
Exposure Limit 2 ppm.

Potential Health Effects

Skin : Avoid skin contact with leaking liquid (danger of frostbite).

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Material Safety Data Sheet

2,3,3,3-Tetrafluoroprop-1-ene, HFO-1234yf

Version 1 Revision Date 09/28/2010 Print Date 10/18/2010

May cause frostbite.

May cause skin irritation.

Eyes : May cause frostbite.

May irritate eyes.

Ingestion : Unlikely route of exposure.

Effects due to ingestion may include:
Gastrointestinal discomfort

Inhalation : May be harmful if inhaled.

May cause respiratory tract irritation.
Gas reduces oxygen available for breathing.
Causes asphyxiation in high concentrations. The victim will
not realize that he/she is suffocating.
Inhalation may cause central nervous system effects.
Vapours may cause drowsiness and dizziness.

Chronic Exposure : None known.

Carcinogenicity

No component of this product present at levels greater than or equal to 0.1% is identified as a known
or anticipated carcinogen by NTP, IARC, or OSHA.

SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS

Chemical nature : Substance

Chemical Name CAS-No. Concentration

2,3,3,3-Tetrafluoroprop-1-ene 754-12-1 100.00%

SECTION 4. FIRST AID MEASURES

General advice : First aider needs to protect himself. Take off all contaminated
clothing immediately.

Inhalation : Remove to fresh air. If not breathing, give artificial respiration.

If breathing is difficult, give oxygen. Use oxygen as required,
provided a qualified operator is present. Call a physician.

Skin contact : After contact with skin, wash immediately with plenty of water.
Rapid evaporation of the liquid may cause frostbite. If there is
evidence of frostbite, bathe (do not rub) with lukewarm (not

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Material Safety Data Sheet

2,3,3,3-Tetrafluoroprop-1-ene, HFO-1234yf

Version 1 Revision Date 09/28/2010 Print Date 10/18/2010

hot) water. If water is not available, cover with a clean, soft

cloth or similar covering. Call a physician. Wash contaminated
clothing before re-use.

Eye contact : Rinse immediately with plenty of water, also under the eyelids,
for at least 15 minutes. In case of frostbite water should be
lukewarm, not hot. Call a physician.

Ingestion : Unlikely route of exposure. As this product is a gas, refer to the

inhalation section. Do not induce vomiting without medical
advice. If conscious, drink plenty of water. Never give anything
by mouth to an unconscious person. Call a physician
immediately.

Notes to physician

Treatment : Treat frost-bitten areas as needed. Treat symptomatically.

SECTION 5. FIRE-FIGHTING MEASURES

Flash point : not applicable

Ignition temperature : 405 °C (761 °F)

Lower explosion limit : 6.2 %(V)

Upper explosion limit : 12.3 %(V)

Suitable extinguishing : In case of fire, allow gas to burn if flow cannot be shut off
media immediately.
Apply water from a safe distance to cool container and protect
surrounding area.
Use water spray, alcohol-resistant foam, dry chemical or
carbon dioxide.

Specific hazards during fire : Flammable gas.

fighting Contents under pressure.
Vapours are heavier than air and can cause suffocation by
reducing oxygen available for breathing.
Vapors may travel to areas away from work site before
igniting/flashing back to vapor source.
Fire or intense heat may cause violent rupture of packages.
Cool closed containers exposed to fire with water spray.
Do not allow run-off from fire fighting to enter drains or water
courses.
In case of fire hazardous decomposition products may be

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Material Safety Data Sheet

2,3,3,3-Tetrafluoroprop-1-ene, HFO-1234yf

Version 1 Revision Date 09/28/2010 Print Date 10/18/2010

produced such as:

Hydrogen fluoride
Carbonyl halides
Carbon monoxide
Carbon dioxide (CO2)

Special protective : In the event of fire and/or explosion do not breathe fumes.
equipment for fire-fighters Wear self-contained breathing apparatus and protective suit.
No unprotected exposed skin areas.

Additional advice : In case of fire: Evacuate area. Fight fire remotely due to the
risk of explosion.

SECTION 6. ACCIDENTAL RELEASE MEASURES

Personal precautions : Immediately evacuate personnel to safe areas.

Keep people away from and upwind of spill/leak.
Wear personal protective equipment. Unprotected persons
must be kept away.
Wear self-contained breathing apparatus and protective suit.
Eliminate all ignition sources if safe to do so.
Avoid skin contact with leaking liquid (danger of frostbite).
Ventilate the area.
Vapors may travel to areas away from work site before
igniting/flashing back to vapor source.
Vapours are heavier than air and can cause suffocation by
reducing oxygen available for breathing.
Avoid accumulation of vapours in low areas.
Unprotected personnel should not return until air has been
tested and determined safe.
Ensure that the oxygen content is >= 19.5%.

Environmental precautions : Prevent further leakage or spillage if safe to do so.

The product evaporates readily.
Discharge into the environment must be avoided.

Methods for cleaning up : Use explosion-proof equipment.

No sparking tools should be used.
Ventilate the area.
Allow to evaporate.

SECTION 7. HANDLING AND STORAGE

Handling

Handling : Handle with care.

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Material Safety Data Sheet

2,3,3,3-Tetrafluoroprop-1-ene, HFO-1234yf

Version 1 Revision Date 09/28/2010 Print Date 10/18/2010

Wear personal protective equipment.

Do not breathe vapour.
Avoid contact with skin, eyes and clothing.
Use only in well-ventilated areas.
Pressurized container. Protect from sunlight and do not expose
to temperatures exceeding 50 °C.
Follow all standard safety precautions for handling and use of
compressed gas cylinders.
Use authorized cylinders only.
Protect cylinders from physical damage.
Do not puncture or drop cylinders, expose them to open flame
or excessive heat.
Do not remove screw cap until immediately ready for use.
Always replace cap after use.

Advice on protection : Container hazardous when empty.

against fire and explosion Prevent the creation of flammable or explosive concentrations
of vapour in air and avoid vapour concentration higher than the
occupational exposure limits.
Keep product and empty container away from heat and
sources of ignition.
Do not pressurize, cut, weld, braze, solder, drill, grind or
expose containers to heat or sources of ignition.
Take measures to prevent the build up of electrostatic charge.
Electrical equipment should be protected to the appropriate
standard.
Use explosion-proof equipment.
No sparking tools should be used.
No smoking.

Storage
Requirements for storage : Pressurized container: Protect from sunlight and do not expose
areas and containers to temperatures exceeding 50 °C. Do not pierce or burn, even
after use.
Keep containers tightly closed in a dry, cool and well-ventilated
place.
Keep away from heat and sources of ignition.
Storage rooms must be properly ventilated.
Ensure adequate ventilation, especially in confined areas.
Protect cylinders from physical damage.
Store away from incompatible substances.
Store in original container.

SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION

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Material Safety Data Sheet

2,3,3,3-Tetrafluoroprop-1-ene, HFO-1234yf

Version 1 Revision Date 09/28/2010 Print Date 10/18/2010

Protective measures : Ensure that eyewash stations and safety showers are close to
the workstation location.
Do not breathe vapour.
Avoid contact with skin, eyes and clothing.

Engineering measures : Use with local exhaust ventilation.

Eye protection : Safety goggles

Hand protection : Protective gloves

Gloves must be inspected prior to use.
Replace when worn.

Skin and body protection : Avoid skin contact with leaking liquid (danger of frostbite).
Wear suitable protective equipment.

Respiratory protection : No personal respiratory protective equipment normally

required.
When workers are facing concentrations above the exposure
limit they must use appropriate certified respirators.
Use NIOSH approved respiratory protection.

Hygiene measures : Handle in accordance with good industrial hygiene and safety
practice.
Ensure adequate ventilation, especially in confined areas.
When using, do not eat, drink or smoke.
Remove and wash contaminated clothing before re-use.
Keep working clothes separately.
Do not breathe vapour.
Avoid contact with skin, eyes and clothing.

Exposure Guidelines

2,3,3,3-Tetrafluoroprop- 754-12-1 WEEL TWA 500 ppm

1-ene

HONEYWELL TWA 500 ppm

We are not aware of any national exposure limit.

HONEYWELL STEL 1,500 ppm

We are not aware of any national exposure limit.

SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES

Form : Liquefied gas

Color : clear

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Material Safety Data Sheet

2,3,3,3-Tetrafluoroprop-1-ene, HFO-1234yf

Version 1 Revision Date 09/28/2010 Print Date 10/18/2010

Odor : slight

Molecular Weight : 114 g/mol

pH : no data available

Boiling point/boiling range : -29.4 °C (-20.9 °F)

Vapor pressure : 6,067 hPa

at 21.1 °C (70.0 °F)

Vapor pressure : 14,203 hPa

at 54.4 °C (129.9 °F)

Relative vapour density : 4

(Air = 1.0)

Density : 1.1 g/cm3

at 25 °C (77 °F)
Water solubility : 198.2 mg/l
at 24 °C (75 °F)
92/69/EEC, A.6

Partition coefficient: n- : log Pow: 2.15

octanol/water
92/69/EEC, A.8

SECTION 10. STABILITY AND REACTIVITY

Conditions to avoid : Keep away from heat and sources of ignition.

Pressurized container. Protect from sunlight and do not
expose to temperatures exceeding 50 °C.
Do not pressurize, cut, weld, braze, solder, drill, grind or
expose containers to heat or sources of ignition.
Decomposes under high temperature.
Some risk may be expected of corrosive and toxic
decomposition products.

Materials to avoid : Strong oxidizing agents

Finely divided aluminium
Magnesium
Zinc

Hazardous decomposition : In case of fire hazardous decomposition products may be

products produced such as:
Hydrogen fluoride

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Material Safety Data Sheet

2,3,3,3-Tetrafluoroprop-1-ene, HFO-1234yf

Version 1 Revision Date 09/28/2010 Print Date 10/18/2010

Carbonyl halides
Carbon monoxide
Carbon dioxide (CO2)

Hazardous reactions : Hazardous polymerisation does not occur.

Stable under normal conditions.

SECTION 11. TOXICOLOGICAL INFORMATION

Acute inhalation toxicity : LC50: > 400000 ppm

Exposure time: 4 h
Species: rat

Repeated dose toxicity : Species: rat

Application Route: Inhalation
Exposure time: 2 Weeks
Note: NOEL - 50,000 ppm

: Species: rat
Application Route: Inhalation
Exposure time: 4 Weeks
Note: NOAEL (No observed adverse effect level) - 50,000
ppm

: Species: rat
Application Route: Inhalation
Exposure time: 13 Weeks
Note: NOAEL (No observed adverse effect level) - 50,000
ppm

Genotoxicity in vitro : Test Method: Ames test

Result: 20% and higher, positive in TA 100 and e. coli WP2
uvrA, negative in TA98, TA100, and TA1535.

: Test Method: Chromosome aberration test in vitro

Cell type: Human lymphocytes
Result: negative
Note: Dose 760,000 ppm

Genotoxicity in vivo : Species: mouse

Cell type: Micronucleus
Dose: up to 200,000 ppm (4 hour)
Result: negative

Genotoxicity in vivo : Test Method: Unscheduled DNA synthesis

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Material Safety Data Sheet

2,3,3,3-Tetrafluoroprop-1-ene, HFO-1234yf

Version 1 Revision Date 09/28/2010 Print Date 10/18/2010

Dose: up to 50,000 ppm (4 week)

Result: negative

Genotoxicity in vivo : Species: rat

Cell type: Micronucleus
Dose: up to 50,000 ppm (4 week)
Result: negative

Teratogenicity : Species: rat

Dose: NOAEL (No observed adverse effect level) - 50,000
ppm

: Species: rabbit
Dose: NOAEL (No observed adverse effect level) - 4,000 ppm

Further information : Note: Cardiac Sensitization (dog): No effects for exposures

up to 12% (120,189 ppm)

SECTION 12. ECOLOGICAL INFORMATION

Ecotoxicity effects

Toxicity to fish : LC50: > 197 mg/l

Exposure time: 96 h
Species: Cyprinus carpio (Carp)
Method: OECD Test Guideline 203
Note: No demonstrable toxic effect in saturated solution.

Toxicity to daphnia and other : EC50: > 83 mg/l

aquatic invertebrates. Exposure time: 48 h
Species: Daphnia magna (Water flea)
Method: OECD Test Guideline 202

Toxicity to algae : EC50: > 100 mg/l

Species: Scenedesmus capricornutum (fresh water algae)

Elimination information (persistence and degradability)

Biodegradability : Result: Not readily biodegradable.

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Material Safety Data Sheet

2,3,3,3-Tetrafluoroprop-1-ene, HFO-1234yf

Version 1 Revision Date 09/28/2010 Print Date 10/18/2010

Further information on ecology

SECTION 13. DISPOSAL CONSIDERATIONS

Waste Information: Observe all Federal, State, and Local Environmental regulations.

SECTION 14. TRANSPORT INFORMATION

DOT UN/ID No. : UN 3161
Proper shipping name : LIQUEFIED GAS, FLAMMABLE, N.O.S.
(2,3,3,3-Tetrafluoroprop-1-ene)
Class 2.1
Packing group
Hazard Labels 2.1

IATA UN/ID No. : UN 3161

Description of the goods : LIQUEFIED GAS, FLAMMABLE, N.O.S.
(2,3,3,3-Tetrafluoroprop-1-ene)
Class : 2.1
Hazard Labels : 2.1
Packing instruction (cargo : 200
aircraft)

IMDG UN/ID No. : UN 3161

Description of the goods : LIQUEFIED GAS, FLAMMABLE, N.O.S.
(2,3,3,3-TETRAFLUOROPROP-1-ENE)
Class : 2.1
Hazard Labels : 2.1
EmS Number : F-D
Marine pollutant : no

SECTION 15. REGULATORY INFORMATION

Inventories

US. Toxic Substances : Not On TSCA Inventory

Control Act

: 2,3,3,3-Tetrafluoroprop-1-ene 754-12-1
Australia. Industrial : Not in compliance with the inventory
Chemical (Notification and
Assessment) Act

: 2,3,3,3-Tetrafluoroprop-1-ene 754-12-1

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Material Safety Data Sheet

2,3,3,3-Tetrafluoroprop-1-ene, HFO-1234yf

Version 1 Revision Date 09/28/2010 Print Date 10/18/2010

Canada. Canadian : This product contains the following components that are not on
Environmental Protection the Canadian DSL nor NDSL lists.
Act (CEPA). Domestic
Substances List (DSL).
(Can. Gaz. Part II, Vol. 133)

: 2,3,3,3-Tetrafluoroprop-1-ene 754-12-1
Japan. Kashin-Hou Law : On the inventory, or in compliance with the inventory
List

Korea. Toxic Chemical : On the inventory, or in compliance with the inventory

Control Law (TCCL) List

Philippines. The Toxic : Not in compliance with the inventory

Substances and Hazardous
and Nuclear Waste Control
Act

: 2,3,3,3-Tetrafluoroprop-1-ene 754-12-1
China. Inventory of Existing : Not in compliance with the inventory
Chemical Substances

: 2,3,3,3-Tetrafluoroprop-1-ene 754-12-1
New Zealand. Inventory of : Not in compliance with the inventory
Chemicals (NZIoC), as
published by ERMA New
Zealand

: 2,3,3,3-Tetrafluoroprop-1-ene 754-12-1
TSCA 12B : US. Toxic Substances Control Act (TSCA) Section 12(b) Export
Notification (40 CFR 707, Subpt D)

2,3,3,3-Tetrafluoroprop-1-ene 754-12-1

National regulatory information

SARA 311/312 Hazards : Fire Hazard

Acute Health Hazard
Sudden Release of Pressure Hazard

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Material Safety Data Sheet

2,3,3,3-Tetrafluoroprop-1-ene, HFO-1234yf

Version 1 Revision Date 09/28/2010 Print Date 10/18/2010

California Prop. 65 : This product does not contain any chemicals known to State of
California to cause cancer, birth defects, or any other
reproductive harm.

New Jersey RTK : 2,3,3,3-Tetrafluoroprop-1-ene 754-12-1

Pennsylvania RTK : 2,3,3,3-Tetrafluoroprop-1-ene 754-12-1

WHMIS Classification : B1
A
This product has been classified according to the hazard criteria
of the CPR and the MSDS contains all of the information
required by the CPR.

SECTION 16. OTHER INFORMATION

HMIS III NFPA
Health hazard : 1 2
Flammability : 4 4
Physical Hazard : 0
Instability : 0

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