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BioInformatics Quiz1 Week2

The document is a quiz on sequence alignment. It contains 9 multiple choice questions testing understanding of key concepts in sequence alignment including: whether dynamic programming always produces a unique best alignment; the meaning of symbols in an amino acid sequence alignment; how substitution scores relate to natural likelihood in scoring matrices; and values that would be produced at different points in a sample sequence alignment done with global or local alignment using a given scoring matrix and gap penalty.

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3K views6 pages

BioInformatics Quiz1 Week2

The document is a quiz on sequence alignment. It contains 9 multiple choice questions testing understanding of key concepts in sequence alignment including: whether dynamic programming always produces a unique best alignment; the meaning of symbols in an amino acid sequence alignment; how substitution scores relate to natural likelihood in scoring matrices; and values that would be produced at different points in a sample sequence alignment done with global or local alignment using a given scoring matrix and gap penalty.

Uploaded by

chahoub
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOCX, PDF, TXT or read online on Scribd
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Bioinformatics: Introduction and Methods 生物信息学: 导论与方法

Week 2

Sequence Alignment
Submit your assignment
Due DateNov 2, 7:59 AM CET
Attempts3 every 8 hours
Receive grade
To Pass80% or higher
Grade
—
Sequence Alignment
Graded Quiz • 30 min

Due Nov 2, 7:59 AM CET

Sequence Alignment

Total points 9
1.
Question 1

在使用动态规划进行序列比对时，比对结果是唯一的吗？

Is the best result derived from dynamic programming unique when doing sequence
alignment?

1 point

不唯一

No, sometimes it may have more than one best result.

唯一

Yes, it is unique

2.
Question 2

在氨基酸的序列比对结果中，一个“：”表示什么意思：

What’s the meaning of “:” in the “markup line”of amino acid sequence alignment

1 point
相同的残基

the same residues

两个相似的残基比对到一起

the residues are similar

两个不相似的残基比对到一起

the residues are not similar

一个空位

a gap

3.
Question 3

一种替换在自然界中越容易发生，则这种替换在打分矩阵中对应的数值

The more likely it is for a substitution to happen in the natural world, the ____ its
substitution score in the scoring matrix will be.

1 point

越大

Larger

越小

Smaller

4.
Question 4
Given scoring matrix

and gap penalty d=-5

use dynamic programming to do sequence alignment for this two sequences: AAGT
and AGCT :

If using global alignment, the value of the yellow block is ______

给定上面的打分矩阵和空位罚分 d=-5，利用动态规划对下面两个序列进行比
对： AAGT 和 AGCT

对于全局比对， 黄色格子的值应为______

1 point

-4

1
-8

-6

5.
Question 5

If using global alignment, the value of blue block in question 4 is ______

对于全局比对，第 4 题中蓝色格子的值为______

1 point

-4

-8

6.
Question 6

If using global alignment, the final alignment(s) in question 4 is ______

对于全局比对，第 4 题的最终比对结果是______

1 point

AAG- T

- AGCT
AAGT-

- AGCT

AAGT

AGCT

AAG- T

A- GCT

7.
Question 7

If using local alignment, the value of green block in question 4 is ______

如果进行局部比对，那么第 4 题中绿色格子的值为______

1 point

8.
Question 8

If using local alignment, the value of blue block in question 4 is ______

如果进行局部比对，那么第 4 题中蓝色格子的值为______

1 point
4

9.
Question 9

If using local alignment, the max value we can get from this alignment is

利用局部匹配，我们可以在这个匹配过程中得到的最大的打分是：

1 point

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