Quality Control Answer Key-RED PACOP
Quality Control Answer Key-RED PACOP
Quality Control Answer Key-RED PACOP
exact volume of a certain standard solution to be used E. Assay of Sulfurated Potash, USP
B. Type 239 E. All of the choices 8. Nitrogen content determination of foods and
C. Perchloric Acid in Glacial Acetic Acid VS the first derivative plot is signified by:
5. USP specifies that the standardization of Sodium C. Maxima or minima of the plot
C. Tromethamine transport:
leaf
A. A quantity of not exceeding 0.25 mg Molecular Weight of Potassium
13. An example of drying oil: 18. Titrant used for the official assay of ascorbic acid
B. Yellow to red E. Blue to yellow 19. Equivalence factor for potassium permanganate
17. Calculate the normality factor for 0.1N Sodium C. Gooch Crucible
Thiosulfate VS given the following data: 22. For samples which contain 50-100% of the active
determination=0.05mL C. 0.20-0.25%
24. pH-adjusting agent used in EDTA titrations using A. Determination of total alkalinity of NaOH
26. Reducing titrant that is susceptible to bacterial are commonly based on ______ equation:
27. Actual indicating species in the assay of Hydrogen wavelength which determines the λmax at which the
28. A piece of soft rubber tubing fitted to the end of a E. None of the choices
glass rod. It is used to loosen from the walls of the 33. A suitable detector for radioactive samples:
containing vessel adhering particles that are not A. UV detector D. Vanillin reagent
removable by a stream of water from the wash bottle: B. Echelette grating E. Iodine vapour
C. Geiger-Muller Counter
34. Type of crucible that can withstand high 40. Most popular indicator electrode for pH
temperature and is suitable for use in ignition of drugs determinations that involves the exchange of
36. Measures the free fatty acid present in a given B. Gay-Lussac Method E. Volhard Method
B. Ester Value iodide and red mercuric iodide used for the detection
A. Acidimetry paddle apparatus are used for what in-vitro test for
38. Official method of water content determination of 44. In weight variation test for tablets, a 5.0%
39. Analyte that involves an alkalimetric type of assay: C. More than 324 mg
B. II and III E. I, II and III C. Will discharge the color of permanganate ion
46. Solve for the acid number of a 2g sample of cod E. Will turn the solution green
liver oil which required 4.5mL of 0.02 KOH in the 52. EDTA titration using dithizone TS as indicator
A. 0.25% D. 2.5mg/g A. 2 D. 10
C. 25mg/g C. 7
47. Diazotization assay is used for analysis of what 53. The water content of an 875.4mg samle of dried
A. Mercaptans D. Cyanides analyzer. What is the % w/w H2o in the leaves if the
instrument? C. 62.35%
B. ph meter E. Spectrophotometer material which is volatilized and driven off under the
49. Masking agent that permits the determination of A. Water content Determination
C. Dissolution
56. Type of chromatography wherein the mobile 63. Suitable form of starch for the preparation of
57. Tromethamine is a primary standard used for the Thiosulfate VS that imparts stability to the volumetric
B. Acetic acid E. Methanol 65. Volumetric solution that is used for analysis of
C. UV lamp D. Dichlorophenol-indophenol VS
69. A 1.4500g sample of liquefied phenol was A. Hanus method D. Karl Fischer method
dissolved in enough water to make 1000mL. A 30mL B. Hubl’s method E. Winkler method
sample of the solution was treated with 30mL of 0.1 N C. Wij’s method
Bromine Vs and HCL. The mixture was treated with 74. A polarity scale of solvent arranged according to
potassium iodide and titrated with 7.38mL of 0.1N increasing eluting power:
sodium Thiosulfate VS. It was also found that 21mL of A. Electromotive series D. pH scale
0.1N Sodium thiosulfate VS was required in the B. Eluotropic series E. Partition coefficient
bromine VS was treated with KI and HCL. Calculate 75. The assay of Opium for % Morphine content is an
70. What is the pH of a 0.400M HNO3 solution? 76. An unknown sample of a soluble sulphate
additional 16.30mL on further titration to a methyl 77. The acid value of a certain fixed oil is .96 and the
orange endpoint.(MW NaHCO3=84.01g/mol) ester value is 2.48. What is the saponification number
magnetic field, the protons absorb radiant energy and 78. Unsaponifiable matter in the plant matter may
B. Acid value E. Ester value 86. Analyte that is can be assayed by ferric chloride
80. Assay which involves back titration: A. Antimony potassium tartrate D. Titanium Dioxide
B. Solid potassium hydroxide E. All of the choices 88. Equivalence factor when arsenic trioxide is used
83. Reproducibility of data within a series of results is A. Ammonium thiocyanate D. Oxalic acid
B. Relative error E. Q-test 90. Titrimetric assay for ferrous salts employ what
C. Eriochrome black T A. 1 D. 6
done using:
A. Scott volumeter D. A and B D. Indication of molecular structure
conversion to oxalic acid and titrating with acidified B. Rocking and wagging
95. Extrction using two immiscible solvents using a C. Indeterminate, personal error
B. Nernst’s law E. Law of entropy 102. What is the pH of a 0.1M solution of acetic acid?
C. Rf value (Ka=1.75x10-5):
96. Organic precipitant employed for the assay for A. 5.00 D. 7.00
97. A parameter that denotes the nearness of the measured volume of base:
involves ______ step to separate the alcohol from the B. 28% E. 100%
D. Soxhlet extraction, optical rotation 112. Saponifying agent used for the analysis of
106. An instrument that produces ions the substance A. alcohol KOH VS D. A and B
(charge to mass) ratio, and records the relative C. strong ammonia solution
abundance of each ionic species present: 113. Used to determine the content of inorganic
108. if an air-dried drug containing 10% moisture 114. type of ionization in mass spectrometry which
2.5% ash calculated ion the basis of the air-dried involves a high energy beam of neutral atoms,
drug, what percent of ash would the moisture-free typically Xe or Ar, causing ionization of the sample.
B. Bromine and potassium bromide 115. The microbial assay for niacin and calcium
hydroxyl groups, present in an organic compound: 123. The biological assay for digitalis employs what
118. Samples to be subjected to titration should prepared from the urine of pregnant women:
that errors in buret readings and weighings will not be B. Chorionic gonodotropin E. Progesterone
C. 15mL A. 2 D. 7
cylinder and its volume was 8.5mL. the graduated 126. Assayed residually by EDTA titration:
cylinder was tapped repeatedly following USP A. Calcium carbonate D. Acetic acid
guidelines and the volume of the powder after tapping B. Aluminum hydroxide E. Sodium thiosulfate
was 4.2 mL. what is the hausner ratio of the powder? C. Zinc sulfate
B. Cylinder plate method E. leaker test 128. Sodium and potassium ions are determined by
C. Bacterial endotoxins test this method which involves the emission of energy of
121. Vitamins assayed by fluorometric method: a particular wavelength when diluted solution of a
D. Tandem mass spectrometry 134. Calibration weights that are used as working
129. A self-indicating volumetric solution: balances, and laboratory weights for routine analytical
A. Iodine VS work:
oxidation step via oxygen flask combustion prior to 135. A substance of known purity that is used for
131. Preferred titrant for the analysis of ferrous salts meniscus to prevent ______:
in mixtures that contain excipient or diluents that have A. Color blindness D. Calibration error
133. The law which relates the power of the incident A. Alkaloid content of opium
and transmitted beams to the thickness and B. Cherry juice for malic acid
E. Dimercaprol
139. Kjeldahl method: 145. Powder flow testing:
140. The following tests cannot be done by ignition: A. Carbonate ion D. A and B
E. A, B and C A. I D. IV
143. Azeotropic distillation is utilized in the USP for 150. In pharmaceutical assaying, the official
144. Calculate for Rf value given the following data: 151. Titanium Dioxide is assayed by what method?
C. 27.84 NF:
A. 1 D. 4 A. 500-550oC D. 1000-1200oC
B. 2 E. 10 B. 550-700oC E. 1200-1600oC
C. 3 C. 800-1000C
153. Calibration of burets may be done using_: 158. Represent the inorganic salts naturally occurring
A. Kiehl buret in the drug and adhering to it, but may also include
154. Given the following log Kf values for the C. Loss on ignition
following metal ion-EDTA complexes, which of the 159. Vitamin b12 activity assay employs what method
activity:
A. II and III D. III only
A. Turbidimetric assay D. A and C
B. I and IV e. I, II, III AND IV
B. Brine shrimp assay E. B and C
C. I only
C. Cylinder-plate assay
155. Sodium tetraphenylboron will quantitavely 161. Cultute media of fungi:
precipitate: A. V5 agar
I. Alkaloids B. Eosin- Methylene blue media
II. Quaternary salts C. Thioglycollate media
III. Silver ions
D. Saboraud’s dextrose media
B. I and II E. I and III 162. Plane polarized light is produced by what type of
__ to ensure to complete reaction. 170. A type of redox reaction that leads to n increase
C. 13 C. Reduction E. Displacement
belladonna leaf ( calculated as atropine) if 15 ml of 171. A specific gravity bottle that has a thermometer
0.0210 N sulfuric acid was added to the extracted stopper and a capillary overflow tube:
alkaloids and 7.30 ml of 0.0198 N sodium hydroxide A. Geissler pycnometer D. Lovi’s beads
was required for the residual titration. The weight of B. Pycnometer E. Saccharometer
reaction, 2 moles of atropine consume 1 mole of 172. A nicol prism is an intergral part of what
167. An acetylization flask is used in the titration can lead to what type of error?
C. Carvone content of caraway oil 174. Given the ff. Ksp values for the ff. sulfides, rank
168. If a 1.2500 g sample of Zinc oxide, 95.0% ZnO, MnS= 3.0 x 10 -14
acid in the casual way, what volume of 0.9765 N Cos = 4.0 x 10-21
sodium hydroxide would be required in the back A. CdS>Cos> Mns D. CoS< CdS < MnS
titration? (MW of ZnO= 81.38 g/mol). B. CdS<Cos< Mns E. None of the choices
C. CdS>MnS>CoS A. Ferrous ammonium sulphate TS
176. Sulfated potash is assayed gravimetrically by reaction of the analyte with the titrant and then the
converting it to __, which is then weighed. unreacted excess titrant with another standard
177. Appropriate laboratory apparatus for carrying formed after ignition prior to titration is:
B. Crude Fiber E. Looss on Drying 186. Acid titrant preferred for hot titrations:
A. Wij’s rgt. D. Koppeschaar’s Solution 187. Purpose of chloroform in the assay of Phenol.
D. all of the choices 194. In the assay of peppermint oil for total ester, the
188. In iodometric titration, what should be the color blank determination serves to:
be the color of the solution prior to the addition of A. Account for an absorption if CO2 by the base
C. 4 B. Sodium bicarbonate E. KI
compounding such as aniline and resorcinol; assayed 196. Suitable backtitrant for titration involving the use
192. In ash content determination, incomplete 198. Energy of a molecule that is NOT involve in
193. Fat constant that aids in the detection of the 199. Suitable method of separating highly volatile
E. Medium pressure liquid chromatography 206. this date limits the time during whick the product
A. H2O is a base, and HF is its conjugated acid. A. Manufacturing date D. Choices B and C
D. HF is a base and H3O is its conjugated acid. 207. It is a measure of propensity of a powder to be
201. This type of airflow has a varying velocity and is A. Bulk density D. Carr’s index
202. It is a property of liquids that is closely related to A. Liquid filled soft capsule
203. In the absolute scale, viscosity is measured in 209. Initially, how many samples are required for
B. Contipoise E. Milinewton C. 20
204. This test determines the resistance to water dosage forms, EXCEPT:
attack of new glasses containers EXCEPT: A. viscosity . Particle size distribution estimation
205. it is an indirect measure if inorganic molecules A. particle size distribution D. deliverable volume
213. Minimum fill is applicable to any of the ff., C. limit test for sulfides
A. container with a labeled amount of 60g or less E. limit test for acetates
Container with a labeled amount of 150g or less 219.This Raw Material Quality Control test entails the
D. container with a labeled amount of more than 150g A. Limit test for Chloride
214. Minimum fill can be applied to such articles, B. limit test for sulfates
215. Color comparison tubes are used for what official retention factor.
216. All of the ff. are used as colorimetric standars, the manufacturing process, and maybe returned to
217. This Raw Material Quality Control test entails 222. which of the ff. is an official ID test for Aspirin
A. tartration D. stoichiometry
B.Azeotropic distillation E. NOTA 230. The performance variationtest is performed in
226. Which of the ff. is used to identify peaks in the C. USP Prednisone Tablet RS
228. The test for conformity is required for the ff. 30o is said to have
A. Suppositories D. Solutions in soft capsules B. Good flow property E. Very poor flow property
229.Passage of fluid or solution through a sterilizing has a hausner’s ratio of 1:20 has a/an
D. Disinfection 235. The test limit for powdered glass test of highly
A. 5.0mL D. 1.5mL
B. 8.5mL E.1.8mL 242. The ff. are dissolution media employed in the
236. The critical test parameter for each dissolution bioequivalence, except:
237. The test limit for powdered glass test of general C. Measurement in a tachometer
238. This is a purified water that has been boiled B. Measurement in a volumeter
A. Distilled water Carbon-dioxide free water 245. A carr’s index of 27 implies a/an
of the substance should be held to within 246 Dissolution testing should be conducted at this
for the drug release requirement of transdermal 247. Disintegration testing should be conducted at
C. Apparatus 6 C. 37+0.2oC
241. Reciprocating cylinder is also known as: 248. delayed release tablet can also be called
249. Buccal tablet should disintegrate within crumbling when external stresses are applied.
250. It is a test to detect or quantify endotoxin from 257. This hardness tester is based on compressing
Gram negative bacteria using amoebocyte lysate from tablets between two jaws via a spring gauge and
D. Surface contamination test 258. Powder fineness can be blassified using this
C.Ebbuliooscopic constant 259. The ff. shoud be strictly avoided when using
252. This test determines whether the dose in a batch B. Cleaning using liquid stream
of units is uniform and it the dosage form can deliver C. Removal of blockade by brushing
the right amount of dose in each patient D. Rinsing with nitric acid
253. This test stimulus the physiological conditions of B. Air Entrapment method-Air jet sieving
the body and can therefore predict bioavailability as C. Air Entrapment method- sonic sifter sieving
255. This test shows how well a resists chipping ang A. Light obscuration particle count test
units and if each unit in a batch has a drug substance volume of 0.02N H2SO4 consumed for trials 1 and 2
within a narrow range around the label claim. were found to be 0.70mL and 0.75mL, respectively,
A. Content uniformity D. Solubility and corrected for a blank. The general description of
263. This test will determine whether a suspension B. Treated soda-lime glass
will not settle out rapidly in the container, will become C. soda lime glass
fluid on shaking, and will remain so long enough for a D. General- purpose soda-lime glass
A. Sedimentation volume D. Minimum fill 269. Example/s of product/s where containers of type
264. This test provides assurance that oral liquids will, B. Hair cream
the volume of dosage form that is declared on the D. Salicylic acid ointment
A. Sedimentation volume D. Minimum fill 270. 6 ampoules were filled with medium up to height
265. This test classifies whether the suspension is 8.25mL. The filling volume for the particular ampoule
266. Method 1 of determining particulate matter in 271. Based on the previous problem, the volume(mL)
injections cannot be applied to, EXCEPT: of the test liquid necessary for one titration should be:
C. Liposomes C. 100
267. This method of determining particulate matter in 272. Referring to item # 70, the extraction solutions
injections utilizes a binocular microscope: are analyzed by titration. How many trials are
B. Method 2 E. NOTA A. 2 D. 5
C. Method 3 B. 3 E. 6
C. 4
273. The volume(mL) of 0.02N H2SO4 for treated A. Bulk density D. Hausner’s ratio
soda lime glass with a volume of 80mL should not B. Tapped density E. NOTA
B. 0.7 E. 1.2 utilizes the knowledge that a water soluble dye will
274. the filing volume is the volume to be filled with an oil-soluble dye will taken up by the oil phase:
_____ in the container for the purpose of the test: A. Dilution Test D. B and C
275. Sterile filling facilities are usually: to be unobjectionable the number and size of discrete
C. Class10000 A. Sterility
276. For ampoules the filling volume is the volume up B. Metal particles in ophthalmic ointment
A. Neck D. Vent D. pH
277. A glass container intended to provide protection presence of polymorphic form etc.:
278. Sublingual tablets must disintegrate within: temperature at which the semisolid melts and
C. 1hour C. solubility
279. This refers to the ratio of the mass of an 284. What is/are the required immersion fluid/s for
untapped powder sample and its volume including the coated tablets?
E. B and C C. interception
285. This test stimulates the flow of a bed of powder 292. This refers to the contamination of a starting
A bulk density D. Carr’s index with another starting material or product during
287. This test is intended for type 1 containers for 294. This is a room or area where the product is
289. Oxidizers and organic peroxides fall under class: B. Controled area
290. it refers to the time a certain constituents passes 296. This type of pressure must be maintained to
through the HPLC column. ensure airflows from the cleanest space to less clean
291. These are the four basic mechanisms in which C. Intermittent pressure
fibrous air filter remove contamination from D. slight pressure E. isobaric pressure
airstreams:
297. This type of airflow is used where particle sizes
A. Unidirectional Airflow
B. Non-unidirectional airflow
C. down flow
D. up flow
E. NOTA
A. critical area
B. Controled area
C. assimilated Area
D. Think-tank area
E. filling area
C. HC emery
fine particles
A. Arrestance D. Adsorption
B. Efficiency E. interference
C. Integrity