1

THE AGENTS INFLUENCE THE A 50 y.o. patient with chronic cardiac insufficiency and glycosides
tachyarrythmia was prescribed a cardiotonic drug. What A. *Inhibition of Na-K-ATPase of cardiomyocyte membranes
EFFECTORY ORGANS drug was prescribed? B. Excitation of B-adrenoceptors of myocardium
С Activation of calcium channels of cardiomyocyte
A *Digoxin membranes
CARDIAC GLYCOSIDES AND OTHER CARDIOTONIC B Dopamine
DRUGS D Oppression of phosphodiesterase of cardiomyocytes
C Dobutamine E. Activation of potassium channels of cardiomyocytes
A patient suffers from chronic left-ventricular
D Amyodarone
insufficiency. What medication should be 9. Indicate the group of drugs which is the most expedient for
E Mildronate treatment of ciliary arrhythmia?
administered?
A *Digoxin A. *Cardiac glycosides
1. A patient with pulmonary edema caused by acute left B. M -cholinoblockers
B Bemegride ventricular insufficiency patient was treated with cardiac C. Na-channels blockers
C Etimizole glycoside. In 10-15 min, his condition improved and maximal D. Beta-adrenomimetics
D Vinpocetine effect - was in 1-1,5 hours, after that the action gradually E. Alfa-adrenoblockers
E Pyracetam decreased. What drug has been injected?
A. * Strophanthin 10. Indicate the group of drugs, overdosage of which is
accompanied by following signs: nausea, vomiting, diarrhea,
A patient that entered the admission office had the В. Digoxin
infringement of heart activity (extrasystoles, delay of
following signs of acute cardiac insufficiency: C. Celanidum
atrioventricular conductivity), headache, vision impairment
D. Digltoxin
paleness, acrocyanosis, frequent shallow respiration. E. Adonisidum
(xanthopsia, diplopia).
What drug is indicated in this case? A. * Cardiac glycosides
2. A patient had been suffering from heart insufficiency was B. Organic nitrates
A *Corglycon treated with digoxinum. He took diuretic Dichlothiazidum without С Ca-channels blockers
B Digitoxin the doctor's knowledge and after 2 days he felt worse and was D. Beta-adrenoblockers
C Cordiamin obliged to address this matter to the doctor. Doctor administered E. Angiotensin converting enzyme inhibitors
D Nitroglycerine several drugs to improve patient's state and among these drugs
E Adrenaline hydrochloride was Unithiolum. Indicate the mechanism of action of this agent 11. Why do strophanthin and corglycon possess fast action after
Patient complaines of weakness, dyspnea, low the introduction into the organism?
A. *It has got free sulfhydril groups which bind to the molecules A. * They have low affinity to plasma proteins
extremities oedema. Diagnosis: chronic cardiac of digoxinum B. They have high molecular weight
insufficiency. What medicine should be prescribed B. Promotes excretion of calcium ions from the organism С. They have low molecular weioht
first of all? С. Promotes retention of potassium ions in the organism D. They have high affinity to plasma proteins
A *Digitoxin D. Decrease oxygen demand of the myocardium E. They have short half-life period
E. Creates complexes with calcium ions
B Caffeine
C Papaverine 3. Specify the cardiac glycoside which posseses the fastest onset of ANTIARRHYTHMIC AGENTS.
D Propranolol the action.
A. *Strophanthin 16. Indicate the group of drugs which is used for treatment of
E Raunatin atrioventricular blockade
В. Celanidum (lanatoside)
A patient suffering from chronic cardiac insufficiency A. * M-cholinoblockers
С. Digitoxin
was recommended to undergo a prophylactic course D. Digoxinum B. Ca-channels blockers
of treatment with a cardiological drug from the group E. Adonisidum С. Local anaesthetics
of cardiac glycosides that is to be taken enterally. D. Beta-adrenoblockers
4. What effect of cardiac glycosides is of greatest importance?
What drug was recommended? E. Potassium containing remedies
A. *Increase of myocardium contractility
A *Digoxin B. Increase of myocardium excitability 15. A patient has lengthening of P-Q interval on the
B Strophanthine C. Decrease of myocardium automatism electrocardiogram under the treatment with an antiarrhythmic
C Corglycon D. Decrease of myocardium conductivity drug. What agent could cause it?
D Cordiamin E. Increase of diuresis and elimination of edemas A. *Atenolol
E Cordarone B. Prazosin
8. Indicate the mechanism of cardiotonic action
С. Atropine
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D. Lidocaine membranes
E. Plathyphyllin B. Blockade of sodium channels of the cardiomyocyte A patient suffering from coronary artery disease had
membranes
14. It is necessary to appoint an anti-arrhythmic agent to a patient
C. Blockade or β-adrenoceptors of the myocardium
taken a certain drug many times a day in order to
with ciliary arrhythmia accompanying by bronchial asthma. What arrest stenocardia attacks. Overdose of this drug
D Blockade of α- and β-adrenoceptors of the myocardium
drug from listed below is contraindicated to this patient? finally caused intoxication. Objectively: cyanotic skin
E. Blockade of М-сholinoreceptors of the myocardium
A. *Anaprilinum (propranolol) and mucous membranes, dramatic fall in the arterial
B. Verapamil pressure, tachycardia, respiration inhibition. Blood
С. Aimalin ANTIANGINAL DRUGS
A patient with coronary artery disease was admitted to has increased concentration of methemoglobin. The
D. Digoxine
E. Novocainamidum (procainamide) the cardiological department. For stenocardia drug the patient had taken relates to the following
prevention a drug from the group of beta-adrenoceptor group:
12. Indicate the mechanism of action of Verapamil
blockers was administered. What drug is it? A *Organic nitrates
A * Blockade of calcium channels
A *Metoprolol B alpha-adrenoceptor blockers
B. Inhibition of Na-K-ATPase
B Atropine sulfate C Calcium channel blockers
С Activation of beta-adrenoceptors
C Morphine hydrochloride D Adenosine drugs
D. Activation of M-cholinoceptors
D Oxytocin E Myotropic spamolytics
E. Blockade of beta-adrenoceptors
E Furosemide
13. A patient suffers from allergic reaction to iodine. Indicate an Anapriline therapy caused positive effect in the
antiarrhythmic agent, which is absolutely contraindicated to him. After a tooth extraction a patient felt persistent pain
behind his breast bone. After sublingual intake of an dynamic of the disease of a 44-year-old
A. *Amiodarone woman suffering from stenocardia. What is the main
В. Verapamil antianginal drug the pain behind the breast bone
disappeared, but the patient complained of headache mechanism of the effect of this medicine?
С. Novocainamidum (procainamide)
D. Ornidum (bretytium) and dizziness. What drug are these properties typical A *Blockade of beta-adrenoreceptors and decrease
E. Quinidine sulfate for? myocardial requirements to the oxygen.
A *Nitroglycerin B Decrease of oxidative exchange in myocardium
1. In a clinic, the patient complained of unpleasant sensations
in the heart region, and attacks of weakness and loss of B Propranolol due to enzyme blockade of Krebs' cycle
consciousness. Inspection of the patient's electrocardiogram C Metoprolol C Decreased power inputs of myocardium due to
had revealed the presence of II degree atrioventricular block. D Validol reduced loading
Specify a drug which should be used in this situation. E Verapamil D Increased oxygen supply to the myocardium
A. * Isadrinum A patient who had myocardial infarction was E Decreased need in increasing of oxygen supply to
B. Novocainamide administered 75 mg of acetylsalicinic acid a day. What the myocardium
C. Nitroglycerine
is the purpose of this administration? 1. Determine an antianginal agent by its pharmacological effect.
D. Stropnanthin
A *Reduction of thrombocyte aggregation It insignificantly improves coronary circulation (especially in
E. Anaplilinum subendocardial layers), but the main cause of elimination of
B Inflammation reduction
Indicate the mechanism of anti arrhythmic action of quinidine stenocardia is dilation of peripheral veins and arteries, that leads
C Pain relief
sulphate to decrease of cardiac work and myocardial oxygen demand.
D Temperature reduction Besides, it oppresses the central links of cardiostimulating
A. *Blockade of sodium channels of the cardiomyocyte
E Coronary vessel dilatation reflexes.
membranes
B. Blockade of calcium channels of the cardiomyocyte A patient suffers from stenocardia and takes isosorbide A. * Nitroglycerine
membranes mononitrate. He was prescribed a complementary drug B. Phenihydinum
С. Blockade of β-adrenoceptors of the myocardium with disaggregating effect. What drug is it? С Amiodaronum
D. Blockade о α- and β-adrenoceptors of the myocardium A *Acetylsalicinic acid D. Validolum
E. Blockade of M-cholinoreceptors of the myocardium E. Anaplilinum
B Nitroglycerine
5. Specify the mechanism of anti arrhythmical action of C Propranolol 2. A patient who had been suffering from stenocardia
verapamil D Nifedipine accompanied by cardiac arrhythmia (paroxysmal tachycardia)
A. *Blockade of calcium channels of the cardiomyocyte E Validol and arterial hypertension was admitted to the hospital. Specify
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antianginal drug and the group which it belongs to, which should A. * 4-5minutes B. Heart stops in systole
be administered taking into account the patient's diseases. B. 15minutes C. Decrease of heart beat rate
A. *β-adrenoblocker - anaprilinum С. 1 minute D. Decrease force of the contraction
B. Organic nitrate - nitroglycerinum D. 30 minutes E. Heart stops in diastole
C. Myotropic spasmolytic agent – No-spa E. 1 hour
D. Calcium antagonist - nifedipin HYPO- AND HYPERTENSIVE DRUGS
9. Why are the tablets of nitroglycerine introduced sublingually
E. Potassium channel activator nicorandil only? A patient with hypertensic crisis was admitted to the
cardiological department, he was injected
3. Indicate the nitroglycerin's drug with prolonged action A. *The substance is being considerably destroyed during its first
passage through the liver intravenously with an antihypertensive drug - salt of
A. *Sustac an alkaline-earth metal. What drug was injected?
B. Validolum B. The substance is badly absorbed in the gastrointestinal tract
С. Amylnitrite С The 'substance operates reflexly from oral cavity receptors A *Magnesium sulfate
D. Natrium nitroprussid D. The substance is destroyed under the action of gastric Juice B Potassium chloride
E. Dipiridamolum E. It causes less side-effects in such way of introduction C Sodium hydrocarbonate
4. Indicate the drug which exerts antianginal action because of 10. Determine an antianginal agent according to its D Calcium lactate
decrease of oxygen demand and increase of oxygen delivery to pharmacological effects: dilating coronary arteries it increases E Benzohexamethonium
the myocardium. myocardial blood supply, dilating peripheral veins it decreases A patient with II stage hypertension has been taking
myocardial preload, dilating perypheral arteries it decrease one of hypotensive medications for the purpose of
A. *Nitroglycerinum
myocardial postload, besides it oppresses the central links of treatment. After a time arterial pressure decreased,
B. Anaprilinum
coronaroconstrictive and cardiostimulatory reflexes:
C. Dipiridamolum but the patient started complaining of flaccidity,
D. Talinololum A. *Nitroglycerine
sleepiness, indifference. A bit later he felt stomach
E. Carbocromenum B. Fenigidinum
С. Amiodarone pain. He was diagnosed with ulcer. What hypotensive
5. Indicate the state which requires administration of D. Validolum medication has the patient been taking?
nitroglycerine E. Anaprilinum A *Reserpine
A. *An attack of stenocardia 11. Introduction of an antianginal drug to a patient with stenocardia B Dibazole
B. Acute cardiac failure caused improvement of patient's state and also arterial hypotension, C Furosemide
С Hypertensive crisis tachycardia and throbbing headache. Indicate this drug. D Verapamil
D. Chronic cardiac insufficiency
A. *Nitroglycerine E Captopril
E. Endarteritis obliterans
B. Carbocromen A 66 year old female patient got intravenous injection
6. Indicate the mechanism of action of nitroglycerine С. Dipyridamole of magnesium sulfate solution for the purpose of
A. * Release of NO groups which activate guanylyl cyclase D. Mildronate elimination of hypertensive crisis. But arterial
B. Blockade of calcium channels E. Verapamil pressure didn't go down and after repeated
C. Blockade of adenosine receptors introduction of the same preparation there appered
12. A 50 years old patient has suffered from angina pectoris for
D. Activation ol adenylyl cyclase
several months. As a rule he has successfully used a tablet of sluggishness, slow response, inhibition of
E. Inhibition of phosphodiesterase
validolum during the attack but last 2 weeks this remedy hasn’t consciousness and respiration. What preparation is
7. А patient with ischemic heart disease complaints of worsening been effective. What drug should be administered to the patient for antagonist of magnesium sulfate and can eliminate
of his state that is caused by overdosage of antianginal agent. elimination of the attack? symptoms of its overdose?
What group of drugs can cause this state it it is known that A. * Nitroglycerine A Calcium chloride
concentration of methemoglobin in patient’s blood is increased? B. Nifedipine
B Potassium chloride
A. *Organic nitrates С Verapamil
D. Anaprilinum (propranolol) C Sodium chloride
B. Beta-adrenoblockers D Activated carbon
E. Isosorbide mononitrate
С. Blockators of calcium channels E Potassium permanganate
D. Activators of potassium channels 13. The calcium channels of cardiomyocytes have been blocked on
E. Myotropic coronary dilators an isolated rabbit's heart. What changes in the heart's activity can
happen as a result? A 63 y.o. man with collapse symptoms was
8. After sublingual introduction of nitroglycerine its maximal delivered to the emergency hospital. A doctor
A. *Decrease rate and force of heart beat
concentration in blood is developed in:
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chose noradrenaline in order to prevent E. Nifedipinum been suffering from chronic glomerulonephritis. Indicate the
hypotension. What is the action mechanism of this most effective group of drugs to treat this patient.
5. A patient had been suffering from hypertonic disease
medication? accompanied by chronic bronchitis with asthmatical component. A. *Angiotensin converting enzyme inhibitors
Indicate the drug which is contraindicated due to it's action on the B. Ganglion blockers
A *Activation of alpha-1-adrenoreceptors С. α-adrenoblockers
B Activation of serotonin receptors bronchi.
A *Anaprillinum D. Myotropic spasmolytics
C Activation of beta-adrenoreceptors E. Calcium antagonists
B. Captopril
D Activation of dopamine receptors С. Prazosinum
E Block of M-cholinoreceptors D. Nifedipine THE AGENTS USED IN INSUFFICIENCY OF CEREBRAL
E. Dichlothiazidum CIRCULATION. HYPOLIPIDEMIC AGENTS
1. The patient suffering from arterial hypertension with
hyperkinetic type of circulation and the high contents of rennin, 6. A doctor has administered to a patient clonidine (clophelinum) 1. The patient who had been treated with a vitamin drug for the
accompanied by stenocardia and sinus tachycardia has been for elimination of hypertensive crisis. What class of hypotensive prophylaxis of brain vessel constriction complained of
treating for 10 years. Indicate the group of drugs should be drugs does the named agent belong to? unpleasant sensations: blushing of upper part of the body,
administered in this situation. A * Central neurotropic vertigo, flushing of blood to the head. Which drug exerts this
A. * Beta-adrenoblockers В. Peripheral neurotropic effect
B. Drugs of nitroglycerine С. Diuretics A. * Nicotinic acid
C. Alfa-adrenoblockers D. Drugs affecting the renin-angiotensin system В. Tocopherol acetate
D. Sympatholytics E. Myotropic (vasotropic) hypotensive agents C. Riboflavin
E. Ganglioblockers 7. A patient with hypertensive disease caused by raised D. Thiamini bromidum
2. A 45 year old patient, who had been suffering from idiopathic sympathoadrenal system activity requires administration of a drug E. Calcium pangamate
hypertension, was treated by an antihypertensive drug. After 4 reducing neurogenic tone of vessels. What is the most suitable
days his arterial pressure decreased, but he complained of 2. A patient suffering from atherosclerosis is treated with
agent to be administered? lovastatinum 0,04 g PO before sleep. Why is this drug
sleepiness and psychological suppresion. With which drug was A. *Clophelinum
the patient treated? administered once a day and before sleep?
B. Losartane
A * Clophelinum A. *Cholesterol is synthesized only at night
С. Verapamil
B. Development of sleepiness in the action of the drug.
B. Prazozinum D. Hydrochlorthiazide
С. In the evening the drug is better absorbed.
С. Captopril E. Apressinum (hydralazine)
D. The cataboiism of a cholesterol goes mainly at night.
D. Enalapril E. The cholesterol is excreted from an organism mainly at
E. Apressine 8. Hypertensic crisis characterized by sharp headache, dizziness,
night
hyperemia of face, pains in the region of heart, rapid pulse, arterial
3. A patient who had been suffering from hypertonic disease pressure of 220/110 mm Hg has developed in a patient suffering
had been treated for a long time with the drug from the group of 3. A patient admitted to the neurology department with
from essential hypertension during the visit to the dentist. What complaints of severe headache, nausea, vomiting, feeling of
Rauwolf ia alkaloids and began to complain of heartburn, pain agent is it necessary to introduce to the patient?
in the epigastrial area and bad mood. Indicate the drug which numbness and weakness of the right arm, disorders of speech. BP
A. *Clophelinum (clonidine) – 220/130 mm Hg. During 15 years he had been suffering from
caused these complications.
В. Pinlenum fpempidine) arterial hypertension. After the examination the following
A. *Reserpinum
С. Timolol diagnosis was made: ischemia of the left hemisphere due to
В. Octadinum
D. Moxonidine vascular spasm and impairment of venous outflow. Specify the
С. Clophelinum
E. Anaprilinum fpropranolol) drug which is the most preferable for the improvement of
D. Papaverinum
E. Dlbazolum 9. Indicate the antihypertensive agent which can cause such side- cerebral blood supply due to decrease of hypercoagulation.
effects as dryness in the mouth, constipation and retention of water A. *Xanthinoli nicotinas
4. A patient who had been suffering from arterial hypertension
in the organism В. Sydnophenum
had taken a hypotensive drug, but in an hour his blood pressure
increased and 2 hours after it decreased. Indicate this A. * Clophelinum (clonidine) С. Coffetnum
antihypertensive agent. B. Coraiaminum (nikethamide) D. Meridilum
A *Octadimlm С. Verapamil E. Aminalonum
B. Prazosinum D. Anaprilinum fpropranolol)
E. Nifedipine 4. A patient admitted to a hospital with complaints of decrease of
С. Captoprii
memory, feeling of "noise" in the head. The diagnosis which had
D. Anaprilinum 10. Stable arterial hypertension was arisen in the patient who had
 5
established after examination was atherosclerosis of brain blood D. Very low density lipoproteins B. Impairment of creation of superoxide radicals
vesseles. Indicate the agent which can be administered to the E. Intermediate density lipoproteins С. Impairment of absorption of cholesterol in the intestine
patient. 10. Indicate the principle of an antiatherosclerotic action of D. Impairment of lipolysis in the fatty tissue
A. *Clofibratum Lovastati-num E. Impairment of binding of atherogenous lipoproteins with
B. Euphyllinum endotheliocytes
A. *Oppression of endogenous cholesterol synthesis in the liver
С Dibazolum
B. Inhibition of peroxide radicals formation
D. Nimodipin DIURETIC AGENTS. DRUGS USED IN GOUT.
С. Infringement of exogenous cholesterol absorption
E. Minoxidilum A patient takes digoxin for treatment of cardiac
D. Inhibition of lipolysis in fatty tissue
5. A 58 year old woman suffered from cerebral atherosclerosis. E. Prevention or penetration of atherogenic lipoproteins in insufficiency. What diuretic may increase digoxin
The complex therapy administered by the physician included tunica intima of vessels toxicity due to the intensified excretion of K+ions?
vitamins E and C. Indicate the role of these drugs in the 11. A patient with atherosclerosis of vessels was treated with one A *Hydrochlorothiazide
treatment of atherosclerosis. of the hypolipidemic drugs which reduces cholesterol synthesis
A. *Inhibition of lipids' peroxydation
B Spironolactone
due to inhibition of enzyme 3-hydroxy-3-methylglutaryl-
B. increase of release of the pituitary gonadotropic hormones C Panangine
coenzyme A reductase. Indicate the drug
С. Decrease of release of glucocorticoids in adrenal cortex D Siliborum
A. * Lovastatinum
D. Activation of the antitoxic function of the liver B. Cholestyramine
E Lisinopril
E. Improvement of coronary circulation С. Clofibrate A patient with chronic cardiac insufficiency has been
6. A patient was admitted to the clinic of nervous diseases with D. Nicotinic acid treated with cardiotonic drugs and a thiazide diuretic,
increased arterial pressure (220/130 mm Hg). It was diagnosed E. Probucol but in spite of it there are still edemata and risk of
that he had ischemia of the left hemisphere of the brain as a
12. Among special hypolipidemic agents the most effective ones ascites. What medication should be prescribed to
result of vessel spasm and impairment of venous outflow. amplify diuretic effect of the applied drugs?
are those which block synthesis of endogenous cholesterol in the
Choose the preparation from the listed ones which is preferable
liver. What drug from listed below has such mechanism of A *Spironolactone
for improvement of brain blood supply and which removes
action? B Furosemide
hypercoagulation in an acute period of the illness:
A. * Xantinol nicotinate A. *Lovastatinum C Amyloride
B. Caffeine (coffeinum) B. Clofibrate D Clopamide
С. Meridilum (methylpnenidate) С. Cholestyramine E Manitole
D. Aminalonum (gamma-aminobutyric acid) D. Parmidinum
E. Probucol
The alternate usage of dichlotiazide, etacrin acid and
E. Sydnophenum (pheprosidine) lasix didn't cause marked diuretic effect in patient with
7. Indicate the main effect of Piracetam 13. A patient has the family hypercholesterolemia. Indicate the marked peripheral edema. Increased amount of
A. * Improves memory and cognition drug which may be used due to ability to inhibit the main enzyme aldosterone is in the blood. Indicate the medicine to
B. Decreases the integrating processes in the brain of cholesterol synthesis? be prescribed?
С. Slows down synthesis of GABA in the brain A. * Lovastatinum
B. Colestipol A *Spironolacton
D. Reduces resistance of the brain tissue to hypoxia
E. increases brain necessity in oxygen С. Cholestyramine B Mannit
D. Nicotinic acid C Clopamid
8. A patient was admitted to the neurological department
complaining of memory impairment and decrease of intellectual
E. Probucol D Urea
capacity after the car crash head trauma. Offer the remedy for 15. Indicate the hypolipidemic agent which may be used in E Amilorid
improvement of metabolism in the brain: atherosclerosis of brain arteries Diuretic drug was prescribed to the patient with
A. * Pyracetam (Nootropil) A. *Lovastatinum hypertension in the course of complex treatment. In a
B. Nifedipinum B. Cinnarizine few days BP decreased but signs of hypokaliemia
С. Sydnocarbum С. Pyracetam developed. What drug could cause such
D. Caffeine (coffeinum) D. Tocopherol acetate complications?
E. Analginum (metamizole) E. Ascorbinic acid A *Lasix
9. What class of lipoproteins is the most atherogenic? 16. Specify the principle of antihy-perlipidemic action of B Spironolactone
A. * Low density lipoproteins lovastatinum. C Clophelin
B. Chylomicrons
С. High density lipoproteins
A. *Inhibition of synthesis of endogenous cholesterol in the liver D Triamterene
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E Enalapril increased. Indicate which medicine should be prescribed: A patient suffering from chronic bronchitis takes a
A 65 year old female patient suffers from chronic A. *Spironolactone synthetic mucolytic drug that facilitates the sputum
renal insufficiency accompanied by evident edemata B. Mannit thinning. What drug is it?
C. Amilorid
caused by chronic glomerulonephritis. What diuretic A *Acetylcysteine
D. Clopamid
should be administered for forced diuresis? E. Urea B Diazepam
A *Furosemide C Heparin
7. A doctor administered Allopurinol to a 26-year-old man with the
B Hydrochlorothiazide symptoms of gout. What pharmacological action of Allopurinol D Furosemide
C Chlorthalidone ensures therapeutical effect? E Enalapril
D Cyclometazide A. *Inhibition of uric acid synthesis A 70-year-old man, who suffered from chronic
E Acetazolamide B. Increase of uric acid excretion bronchitis, was prescribed medicine for the cough -
C. Inhibition of leucocyte migration into the joint codeine. What is the mechanism of anticoughing
1.The diuretic agent in dosage 0,025 g 2 times a day had been D. Analgesic effect effect?
prescribed to the patient with the beginning stage of idiopathic E. Antinflammatory effect
hypertension. In 7-8 days, the arterial pressure had slightly
A *Central
8. Indicate the diuretic agent which should be used to treat B Reflex
decreased, but he began to complain of pain in the heart region,
pulmonary edema C Competitive
muscle weakness, and tremor. The analysis of blood has revealed
hypokalemia. Which from the listed drugs may cause this side A. *Furosemide D Local effect
effect B. Hydrochlorthiazide E Peripheral effect
С. Triamteren
A. * Hydrochlorthiazide
D. Spironolactone 1. А patient had been suffering from chronic bronchitis, was
B. Spironolactonum
E. Acetazolamide (diacarbum) treated with an expectorant drug. In a week the symptoms of
С Triamterenum
D. Amilorid rhinitis, tearing, itching of the skin and rashes appeared. What
THE AGENTS AFFECTING THE MYOMETRIUM TONE agent may cause these side effects?
E. Mannit
AND CONTRACTILE ABILITY.
A. * Potassium iodide
3. A patient had taken celanidum for long time due to chronic
A 45 year old woman had referred to her gynaecologist with B. Terpinhydratum
heart failure. The physician administered to him dichlothiazidum
complaints of menorragia. The doctor had administered С Acetylcysteinum
to eliminate leg edemas. Which drug should be taken together
ergometrinum, which helped the woman. Specify the main effect of D. Infusum herbae Thermopsidis
with the diuretic to prevent hypokalemia?
the drug. E. Alatriihydrocarbonas
A. *Kalii chloridum A. * Produces spastic contraction of the myometrium 2. A 40 year old patient has been suffering from bronchial
B. Calcii chloridum B. Accelerates process of coagulation asthma, accompanied with cardiac arrythmia (tachycardia) for 10
С. Unithiolum С Oppresses proliferation of the endometrium cells years. Indicate adrenomimetic which should be administered for
D. Natrii sulfas D Produces vasoconstriction endotheliocytes treatment taking into account accompanied disease.
E. Magnii sulfas E. Produces rhythmic contractions of the myometrium A. *Salbutamol
4. A patient has been treated for a long time with cardiac B. Adrenaline
5. 1 ml of an agent causing contraction of the myometrium was
glycoside digoxinum in connection with congestive heart failure. С. Isadrinum
introduced intramuscularly to a woman after abortion. In few
Now the patient's state is stable, but there are remaining edemas D. Orciprenalin
minutes she began to complain of headache. AP -160l100 mm Hg.
on the legs and face. What diuretic should be taken to avoid side- E. Ephedrine
Earlier she had initial stage of arterial hypertension. Choose among
effects caused by simultaneous administration of cardiac the following drugs which is preferred in this case, taking into 3. Indicate broncholytic which should be administered to a
glycosides and diuretics? account the woman had inclination to arterial hypertension patient suffering from bronchial asthma accompanied with
A. *Spironolactonum A. *Oxytocin stenocardia.
B. Oxodolinum B. Pituitrinum A *Salbutamol
C. Dlchlothiazidum С. Serotoninl adlpinas B. Ephedrine
D. Diacarbum D. Hyphitocinum С. Isadrinum
E. Cyclomethiazidum E. Mammophysinum D. Orciprenalin
6. The usage of dichlotiazide, etacrinic acid and furosemide did E. Adrenaline
not cause marked diuretic effect in the patient with marked 4. A child was born with asphyxia. What agent is it necessary
peripheral edemas. The aldosterone level in the blood is THE AGENTS AFFECTING FUNCTIONS OF THE to introduce for stimulation of breath?
RESPIRATORY SYSTEM А. Promedolum
 7
B.*Aetlumlzole E. Potassium iodide pulmonary edema
C. Prazozin 11. A patient with acute bronchitis I suffers from intolerable dry A. *Furosemide
D. Atropine cough. What from enumerated below agents 'can transform dry B. Hydrochlorthiazide
E. Proserinum cough into wet cough? С. Triamteren
5. To specify an analeptic which possesses sedative activity and A. *Thermopsis grass infusion D. Spironolactone
can be used as desensibilizing agent in bronchial asthma B. Codeine phosphate E. Acetazolamide (diacarbum)
A. *Aethimizole С. Libexinum
B. Camphor 18. Indicate the drug used for elimination of pulmonary edema
D. Glaucine hydrochloride caused by systemic arterial hypertension.
С. Cordiaminum E. Falimint
D. Carbogen 12. Indicate an expectorant agent that is an inorganic substance A. * Pentaminum
E. Dimedrolum and is usually used orally as a solution, rarely as an inhalation, B. Strophanthin
6. Indicate antitussive agent possessing properties of opioid І ft exerts direct irritating action on bronchial glands. С Bemegridum
analgesics A. *Kalium iodide D. Cordiaminum
A.*Codeine В. Bromhexinum E. Spiritus aethylicus
В. Libexinum C. Trypsin 19. Indicate the drug used in pulmonary edema accompanying by
C. Tussuprex D. Acetylcysteine formation of foam to decrease superficial tension of bubbles to
D. Glaucine E. Libexinum turn foam into
E. Falimlnt 13. Mark the group of drugs used for elimination of bronchial A. *Spiritus aethylicus
7. An antitussive agent (1 tablet 3 times a day) was asthma attacks B. Pentaminum
administered to a patient. Cough has decreased but the patient A. *Beta-adrenomimetics С. Strophanthin
has started complaining of dizziness, general weakness and B. M-chotinomimetics D. Bemegridum
arterial hypotension has been' revealed. Indicate the drug. С. Sympatholytics E Cordiaminum (nikethamide)
A. *Glaucine D. Beta-adrenoblockers
В. Codeine E. M-chotinomimetics THE AGENTS INFLUENCING FUNCTIONS OF THE
С Libexinum (prenoxdiazine) 14. A patient with bronchial asthma was treated with the combined DIGESTIVE SYSTEM
D. Oxeladine drug in tablets that caused insomnia, irritability, headache and rise of A 37-year-old man was admitted to the surgical
E. Faiimint arterial pressure. What agent could cause these side-effects? department with symptoms of acute pancreatitis:
8. Indicate the drug oppressing a peripheral link of cough A. *Ephedrine vomiting, diarrhea, bradycardia, hypotention,
reflex B. Adrenaline weakness, dehydration of the organism. What
A. * Libexinum C. Libexinum medicine should be used first of all?
В. Codeine phosphate D. Euphyliinum
С. Ethylmorphine hydrochloride
A *Contrycal
E. Furosemide
D. Bromhexinum B No-spa
E. Atropine suifate 15. A patient suffering from bronchial asthma was treated with the C Platyphylline
9. Thes mechanism of expectorant' action of Thermopsis drug which caused in several days insomnia and tachycardia. D Etaperazine
herb infusion is: Indicate this drug.
E Ephedrine
A. *It stimulates bronchial secretion reflexively irritating the A. * Ephedrine
B. Plathyphylline
A patient suffering from chronic hyperacidic gastritis
stomach receptors takes an antacid drug for heartburn elimination. After
B. Directly stimulates peristalsis of bronchial smooth muscles С. Adrenaline
D. Euphyllinum (aminiphylline) its ingestion the patient feels better but at the same
С. It destroys proteins of sputum
D. Irritates bronchial glands during excretion that leads to E. Salbutamolum time he has a sensation of stomach swelling. Which
stimulation of their secretion of the following drugs might be the cause of such
16. Indicate the mechanism broncholytic effect of adrenaline
E. It inhibits the cough center side effect?
A. * Stimulation of beta2-adrenoceptors
10. Indicate an expectorant agent possessing the reflex type of B. Stimulation of beta1 and beta2-adnenoceptors A *Sodium hydrocarbonate
action С Blockade of beta2-adrenoreceptors B Magnesium oxide
A, * Thermopsis herb infusion D. Stimulation of alfa1 and alfa2-adrenoceptors C Magnesium trisilicate
B. Bromhexinum E. Blockade of N-cholinoceptors D Aluminium hydrooxide
С. Acetylcysteine E Pepsin
D. Trypsine 17. Indicate the diuretic agent which should be used to treat
A liquidator of a breakdown at a nuclear power plant
 8
who was irradiated complained about vomiting that 5. Indicate the drug which increases appetite due to decrease of E. No-Spa (drotaverine)
occurs all of a sudden. What medication should be glucose concentration in the blood
11. Indicate the agent which may be used in an attack of biliary
prescribed? A. *Insulin
colic to relax smooth muscles?
B. Mazindolum
A *Metoclopramide A. *Platyphyllinum
С. Fenfluramine
B Reserpine D. Absinthium tincture B. Paracetamolum
C Atropine E. Phepranonum С. Analginum (metamizole)
D Aeron D. Pentazocine
6. A 32 year old patient had been suffering from the ulcer of the E. Morphine
E De-Nol duodenal bulb was treated with Farmotidin which caused him to
feel better. Indicate the mechanism of action of this agent. 12. A 40 years old patient was admitted to the hospital with the
1. The patient was admitted to the hospital with the diagnosis: biliary colic attack. What agent should be administered in this
peptic ulcer of the duodenum bulbus. Analysis of his gastric A. *Blockade of Н2-histaminic receptors
case?
juice revealed increased acidity. Choose the agent which B. Inhibition of gastrin release
decreases the secretory ability of gastric glands due to blockade С. Suppression of the function of the gastric mucousal cells A. *No-spa (drotaverine)
of H2-histaminic receptors. D. Decrease of release of hydrochloric acid B. Almagel
E. Decrease of pepsin release С Pancreatin
A. *Panitidinum
D. Contrycal (aprotinine)
B. Extract of belladonna 7. A patient suffering from chronic hypoacidic gastritis with E. Metoclopramide
C. Atropinum remained secretory function requires administration of an agent
D. Methacinum which is physiological stimulant of the gastric glands. Indicate this 13. Indicate the drug from the group of myotropic spasmolytics
E. Platyphytlinum agent which is suitable to eliminate pain in intestinal colic
A. *Papaverine
2. A 25 year-old man, suffering from peptic ulcer of the A. *Carbonaceous mineral water
B. Neostigmine (proserinum)
stomach, has been treated with omeprasole. In 3 weeks the ulcer B. Pepsin
C. Piridostigmine
was healed. What mechanism of action does this drug produce? С. Histamine
D. Pilocarpine
A. * Blockade of H+-K+-ANP-ase (the proton pump) D. Diluted hydrochloric acid
E. Prazosine
B. Blockade of M-cholinoceptors E. Natural gastric juice
С. Blockade of synthesis of Gastrin 8. A patient with essential hypertension was treated for a long 14. Indicate a cholagogue agent used for treatment of chronic
D. Blockade of H+-K+-ANP аsе period of time with preparations containing reserpin. During last 2- cholecystitis
E. Blockade of H1 histaminic receptors 3 months he started to suffer from pains in the region of stomach, A. *Allocnolum
heartburn and nausea. The diagnosis of hyperacidic gastritis was B. Absinthium (sagebrush) tincture
3. Patient who had been suffering from chronic gastritis was
made after the clinical examination. Indicate the group of drugs С. Metoclopramide
treated with an antacidic drug, after introduction of which he felt
which possesses etiotropic curative action in this case. D. Almagel
better however at the same time he experienced bloating of the
A. *M-cholinoblockers E. Plathyphyllin
stomach together with eructation. Indicate the drug which might
cause this side effect. B. Astringent agents 15. Specify an agent from the group of hepatoprotectors which
A. *Natrii hydrocarbonas С. Antiacidic agents restores normal structure and function of hepatocytes, used in
D. Inhibitors of proton pump different liver deseases.
В. Magnesu trisilicate
E. H2-histamine receptors blockers A. * Essentiale
С. Magnesii oxydum
D. Almagel 9. Indicate the remedy increasing bile secretion: B. Tetracycline
A. *Oxaphenamidum С. Cholenzymum
E Aluminii hydroxydum
B. Apomorphine D. Tocopherol acetate
4. Indicate the drug to stimulate appetite, mechanism of action С. Cimetidine E. Allocholum
of which is associated with irritation of the mucus membrane of D. Almagel 16. Indicate the drug, which is used in chronic pancreatitis,
the oral cavity, that leads to reflex excitation of the hunger E. No-Spa (drotaverine) accompanied by enzymesT insufficiency, for improvement of
center in the hypothalamus. digestion processes.
10. Indicate the agent which stimulates contraction of gall bladder
A. *Absinthium tincture smooth muscle and causes evacuation of bile into the intestine? A. *Festalum
В. Phepranonum B. Pepsin
A. *Magnesium sulfate in enteral introduction
C. Desopimonum С Acidin-pepsinum
B. Magnesium sulfate in parenteral introduction
D. Fenfluramine D. Natural gastric Juice
С. Dehydrocholic acid
E. Insulin E. Diluted nydrocnloric acid
D. Legaion (silimar in)
 9
17. Why is contrycal (aprotinine) used in the case of acute whole surface of the wound. Specify a drug for local use to stop the B. Ferroplexum
pancreatitis? bleeding. С. Hemostimulinum
A. *It inactivates trypsin which causes autolysis of pancreas A. * Thrombinum D. Cvanocobalaminum
B. It opens Oddies sphincter B. Calcii chloridum E. Ascorbic acid
С. It reduces the activity of hyaluronidase С. Vikasolum
D. It impairs secretion of trypsinogen D. Aminocapronic acid VITAMINS
E. It oppresses secretion of bile E. Ambenum In order to accelerate healing of a radiation ulcer a
18. Indicate an anti-enzymatic agent inhibiting activity of 2. Drugs delaying blood coagulation (anticoagulants) are used for vitamin drug was administered. What drug is it?
trypsin, kallikrein and fibrinolysis prevention and treatment of thrombosis. Specify an anticoagulant A *Retinol acetate
A. *Confrykal (aprotinine) which antagonist is protamine sulfate. B Retabolil
B. Cholenzymum A. * Heparinum
C Prednisolone
E. Pancreatin B. Meodicoclmarin
D. Pancreozymin C. Syncumarum D Levamisole
E. Festal D. Phenilinum E Methyluracil
E. Sodium hydrocitrate A 64 year old woman has impairment of twilight vision
19. A 37-year-old man was admitted to the surgical department
3. A patient was delivered to a hospital with complaints of loss of (hemeralopy). What vitamin should be recommended
with the symptoms of pancreatitis: vomiting, diarrhea,
bradycardia, hypotension, weakness, dehydration. What appetite, decrease of body weight, fatigue, pain around the epigastric in the first place?
medicine should be used first of all? area. Examination of the blood revealed megaloblastic anemia. A *Vitamin A
A. *Contrycal Specify the main agent for the treatment of this disease. B Vitamin B2
B. Etaperazine A. *Cyanocobalaminum C Vitamin E
C. No-spa B. Ferri lastas D Vitamin C
D. Platyphylline C. Folic acid
E Vitamin B6
E. Ephedrine D. Fercovenum
E. Coamidum A patient presents with twilight vision impairment.
Which of the following vitamins should be
THE AGENTS INFLUENCING THE BLOOD 4. Specify the antagonist of the anticoagulants with indirect action.
COAGULATION, ERYTHRO- AND LEUCOPOIESIS. administered?
A. *Vikasolum
Before tooth extraction a patient was advised to take B. Fercovenum A *Retinol acetate
a certain drug for haemorrhage prevention. What С Pentoxylum B Cyanocobalamin
drug was advised? D. Protamini sulfas C Pyridoxine hydrochloride
E. Contrykalum D Ascorbic acid
A *Vicasolum
B Heparin 5. Specify the coagulant agent available for local use only (to stop E Nicotinic acid
C Asparcam bleedings from small blood vessels). A patient suffers from vision impairment -
A. *Hemostatic sponge hemeralopy (night blindness). What vitamin
D Magnesium sulfate
B. Vikasolum preparation should be administered the patient in
E Dimedrol С Calcii chtoridum
A patient ill with essential hypertension was order to restore his vision?
D. Fibrinogen
recommended a drug that prevents thrombosis. It is E. Aminocapronic acid A *Retinol acetate
to be taken parenterally. What drug is it? 6. Specify the thrombolytic agent which belongs to with direct B Vicasol
A *Heparin action plasma proteins. C Pyridoxine
B Amben A. *Fibrinolysin D Thiamine chloride
В. Streptokinase E Tocopherol acetate
C Protamine sulfate
C. Contrycalum
D Neodicumarin D. Urokinase 1. A 64 year old woman suffers from night blindness
E Syncumar E. Streptodecase (hemeralopia). What vitamin drug should be recommended?
7. Inhibition of leukopoiesis is observed in a 43 years old A. * Retinolum
1. The patient was admitted to the traumatologic department due
roentgenologist. The amount of leukocytes 3,5*109/l. Specify the B. Riboflavin
to fracture of chin bones, damages of soft tissues and massive
agent to be used for correction of leukopoiesis. С. Tocopherolum
bleeding. Examination revealed paleness of the skin, pain in
palpation of area of trauma, swelling of the skin, bleeding on the A. *Pentoxylum D. Pyridoxinum
 10
E. Ascorbic acid B. It is faster absored drug should be administered for treatment of this disease?
С It is longer circulated in the blood A. *Cyanocobalamine
2. A 58 year old woman suffers from cerebral atherosclerosis.
D. It is faster penetrated to the bone marrow B. Ferroplexum
Complex of her pharmacotherapy includes drug of vitamin E &
E. it isn't destroied in the liver С. Hemostimuline
С. Which pharmacological effect of these drugs is the main for
7. A patient has diarrhoea, dementia and dermatitis. What vitamin D. Ferrum-lek
treatment of this disease?
has to be included into the complex pharmacotherapy? E. Folic acid
A. * Inhibition of free-radical oxidation of lipids A. *Nicotinic acid
B. Increase of gonadotropic hormones synthesis in the pituitary B. Thiaminum 13.Which of the acids below decreases permeability of
body C. Cyanocobalaminum connective tissue structures, possesses antioxidant activity due
С. Decrease of glucocorticoids release by adrenals D. Panthotenic acid to ability to be transformed from the oxydized form into
D. Strengthening of the antitoxic function of the liver E. Riboflavinum reduced and on the contrary?
E. Improvement of the coronary circulation A. * Ascorbic acid
8.There is an inhibited coagulation in the patient with bile ducts B. Hydrochloric acid
3. A patient who had been taking л vitamin drug for the obstruction, bleeding due to the low level of absorbtion of a C. Mefenamic acid
prevention of cerebrovascular spastic reactions began to vitamin. What vitamin is in deficiency? D. Aspirin (acetylsalicylic acid)
complain of unpleasnt feelings: hyperemia of the face and upper A. *Vitamin К E. Aminocaproic acid
part of the body, vertigo, feeling of blood influx into the head. B. Vitamin D
What drug may cause these side-effects 14. For synthesis of the basic substances of connective tissue
С. Carotene
A. *Nicotinic acid (mucopolysaccharides and collagen) an essential agent is:
D. Vitamin A
В. Tocopheroli acetas A. * Ascorbic acid
E. Vitamin E.
C. Nicotinamidum B. Nicotinic acid
9. A patient with diabetes mellitus is treated by injections of
D. Thiamin/ bromidum С. Folic acid
vitamin B1 to eliminate metabolic acidosis. Which biochemical
E. Calcii pangamas D. Salicylic acid
mechanism of action of vitamin B1 ensures the positive effect?
E. Acetylsalicylic acid
A. * Activation of dehydrogenases of the Krebs cycle
4. A patient had been taking vitamin D for a long time for B. Activation of adenylate cyclase 15. Radiation therapy is performed to the patient. What vitamin
treatment of rickets. Soon the signs of vitamin D intoxication С. Blockade or phosphodiesterase drug with antioxidant properties is necessary for administration
developed: loss of appetite, nausea, headache, fatigue, increase of D. Acceleration of acetylcholine synthesis to increase stability of tissues in this case?
body temperature, etc. What vitamin decreasing the toxic E. Acceleration of adrenaline synthesis A. * Ascorutinum
influence of vitamin D should be administered?
10. Metabolic acidosis arose in a patient due to impairment of B. Vitamin B6
A *Vitamin A С Thiamine chloride
carbohydrate metabolism and accumulation of ketoacids in the
B. Vitamin С D. Cyanocobaiamine
organism, indicate the vitamin drug which promotes its
C. Vitamin В12 E. Folic acid
elimination due to decrease concentration of ketoacids.
D. Vitamin PP
E. Vitamin B2 A. *Thiamine 16. The woman of 25 years who anted to get thin was on a diet
B. Pyridoxins hich consisted of 2 cups of coffee ithout sugar, 3 crackers from
5. A 55 year old patient was admitted to the haemotological С. Folic acid white bread, 2 sausages or 2 eggs in a day within 1,5 months.
department with signs of acute anemia. After laboratory D. Riboflavine The mass of a body has dropped on 5 kg, but there were
examination megaloblastic hyperchromic anemia was diagnosed, E. Ascorbic acid developed strong headaches, often nasal bleedings, bleeding,
which drug must be administered to the patient first of all?
11. A patient suffers from chronic alcoholism with the following sickness of gums, shaking of teeth, -.helling of sfcin and
A. *Cyanocobalaminum shedding of hair.What vitamin drug is expedient in this (ase?
symptoms: pain in arms and legs, impairment of skin sensitivity,
B. Hemostimulinum
muscle weakness, edemas and increased amount of pyruvate. Which A. *Ascorbic acid
C. Ferroplexum
vitamin drug should be prescribed to the patient? B. Folic acid
D. Ferrum-Lek
A. * Thiamine C. Retinol acetate
E. Folic acid
B. Ergocalciferol D. Cyancobalamine
6. A 55 year old patient suffering from hyperchromic anemia C. Retinol E. Vikasolum (Menadione)
obtained long-term treatment with vitamin В12 parenterally. Why D. Rutin
17. The patient who was treated by a vitaminic drug for
the parenteral way of introduction of vitamin B 12 is prefered more E. Vikasoium (Menadione)
prophylaxis of vasospasms of the brain, has developed
than the peroral way? 12. 55 years old patient was admitted to the hematological complaints of the unpleasant sensations related to taking of this
A.*It isn't absorbed in the intestine in oral introduction due to department with acute anemia: RBCs - 1,5 x 10 12/litre; Hb - 80g%, medicine: reddening of the face and the upper half of a trunk,
deficit of gastromucoproiein colour index - 1,3. Hyperchromic anemia was diagnosed. Which giddiness, sence of flush of blood to a head. For what drug the
 11
specified side-effects are characteristic? exchange of phosphorus and calcium in an organism, promotes C. Calcium chloride
A. *'Nicotinic acid sedimentation of calcium in bone tissue and dentins. Determine a D. Ammonium chloride
drug. E. Potassium chloride
B. Nicotinamidum
C. Thiamine bromide A. *Ergocalciferol
2. During treatment of the patient with digitoxin, extrasystoles,
D. Tocoferol acetate B. Tocoferol acetate
muscle weakness, diarrhea, vomiting, and impairment of vision
E. Calcium pangamate С. Retinoli acetate
developed. What drugs should be used to eliminate these signs of
D. Vikasolum (Menadione)
18. Bioflavonoids (rutin, quercetin) possess all listed below intoxication?
E. Thyreoidinum
pharmacodynamic effects, except for: A. * Drugs of potassium
24. Parasthesia, xeroderma arid sticking out of fontanel are B. Drugs of calcium
A. * Dilation of capillaries
observsed at the 6 months child under the treatment by a vitaminic С. Iron preparations
B. Antioxidant activity
drug. Specify this drug. D. Drugs of sodium
C. Inhibition of hyaluronidase activity
A. *Ergocalciferol E. Drugs of magnesium
D. Decrease of permeability of capillary wall
E. Protections of ascorbic acid, assistance to its transport and B. Pyridoxine
3. What agent acts as magnesium ions' antagonist and is used in
accumulation С. Riboflavin
overdosage of parenteral introduction of magnesium sulphatis?
D. Retinoli acetate
19. 64 years old woman suffers from hemeralopia (disturbance E. Tocoferol acetate A. *Calcium
of vision in darkness). What vitaminic drug should be B. Potassium
25. The dentist administered to his patient liposoluble vitamin with C. Sodium
recommended her first of all?
antioxidant activity for treatment of parodontitis. Specify this D. Iron
A. *Retinoli acetate vitaminic drug. E. Bromine
B. Tocoferol acetate
A. * Tocoferol acetate 4. Specify the drug which eliminate both intra- and extracellular
C. Pyridoxin
B. Ascorbic acid acidosis.
D. Ascorbic acid
C. Rutin
E. Riboflavin A. *Trisaminum
D. Nicotinic acid
B. Natrii hydrocarbonas
20. What vitamin promotes growth and development of E. Ergocalciferol
С. Natrii lactas
epithelial cells, including epidermal ones?
26.A doctor administered tocoferol acetate to a patient with D. Ammonii chioridum
A. *Retinol ischemic heart disease. What effect of a drug does the doctor E. Natrii hydroxydum
B. Ergocalciferol expect?
C. Ascorbic acid 5. Specify the drug of first choice to be administered in a 7-year
A. *Antioxidant old child with multiple caries.
D. Nicotinic acid
B. Spasmolytic A. *Calcii glycerophosphas
E. Lipoic acid
С. Hypotensive B. Calcii gluconas
21. 39 years old patient suffers from hyperkeratosis, disturbance D. Increase of oxygen delivery to myocardium С. Calcii chloridurn
of vision in darkness, frequent infectious diseases. What E. Positive inotropic D. Calcii hydroxydum
vitaminic drug should be administered for treatment . 27. What enzymatic drug is used with the purpose of dropping of E. Calmecinum
A. *Retinol acetate density and rising of permeability of connective tissue structures?
B. Pyridoxin 6. The worker who several days ago started working in foundry,
A. *Lidase was addressed to the doctor with complaints of headache,
С. Riboflavin B. Lipase
D. Ergocalciferol nausea. Due to excessive diaphoresis he drank nearly 5 liters of
С. Cocarboxylase tap water per day. What drug will promptly and effectively
E. Tocoferol acetate D. Cholines terase
22. What vitamin is formed in skin under eliminate the specified signs and normalize state of the worker?
E. Amylase
influence of ultraviolet radiation? A. * Sodium chloride
A. *Cholecalciferol PLASMA SUBSTITUTES. AGENTS FOR CORRECTION B. Decamevitum
B. Ascorbinic acid OF WATER-SALT BALANCE С Aspirin (acetylsalicylic acid)
C. Retinole acetate 1. A patient was admitted to the intensive care unit after taking a D. Analginum (methamizole)
D. Calcium pantotenate large dose of Phenobarbitalum with the purpose of suicide. E. Pentalginum
E. Riboflavin Investigation of the patient revealed respiratory olic acidosis. What 7. Ketoacidosis and dyspnoe are observed at the patient with
drug should be used for the correction of acid-base state? non-compensated diabetes mellitus. Which drug should be used
23. To the child with signs of rachitis the pediatrist and the A * Trisaminum for normalization of patient’s state?
"dentist administered a liposoluble vitamin which influences an B. Sodium chloride
 12
A. *Sodium hydrocarbonate D. Ringer-Locke solution B. Bemegrid
B. Naloxone E. Polydesum С. Nalorphine
C. Bemegride D. Naloxone
D. Pananginum PRINCIPLES OF TREATMENT OF ACUTE POISONINGS E. Methylenum coeruleum (methylene blue)
E. Ammonium chloride BY DRUGS
6. A 38 years-old male was admitted to ICU of a hospital with
8. It is necessary to eliminate ketoacidosis at the patient with 1. A 38 year-old patient was admitted to a hospital due to acute severe poisoning by mercury chloride. Determine specific
sugar diabetes complicated by hyperglycemic coma. What poisoning with mercury dichloride. Indicate the antidote which antidote:
solution, being the intracellular buffer, can be administered? should be introduced to the patient immediately.
A. *Unithiol
A. * Trisamine (trometamol) A. * Unithiolum B. Dipiroxime
B. Solution of Sodium hydrocarbonate B. Dipyroximum С. Atropine
С. Solution of Sodium lactate С. Atropinum D. Nalorphine
D. Neohemodesum D. Nalorphinum E. Isonitrosine
E. Ringer’s solution E. Isonitrosinum
9.Ths patient suffering from ollagenosis has been treated for a 2. A patient was admitted to a hospital by the ambulance due to CHEMOTHERAPEUTICAL DRUGS
long time by Prednisolone in a dose of 30 mq per day. Recently acute poisoning with morphine. Indicate the agent which is used for ANTISEPTICS AND DESINFECTANTS
he has started to complain of painful convulsions of skeletal gastric lavage in this situation.
Burned skin surface was treated with a certain
muscles of lower extremities. What agent may be used or A. *Potassium permanganate preparation. Its antiseptic properties are provided by
improvement of patient's state? B. Natrii hydrocarbonas
atomic oxygen that is formed in presence of organic
A * Panangin С. Furacilinum
D. Tanninum substances. What preparation was applied?
В. Ergocatciferol
С. Calcitonin E. Boric acid A *Potassium permanganate
D Diazepam 3. In a patient with syphilis there are grey stains on the oral cavity B Furacillin
E. Aminazine (chlorpromazine) mucosa and the signs of nephropathy developed during treatment C Chlorhexidine bigluconate
10. The patient was admitted to the hospital with signs of with bismuth compounds. Specify the agent which is used as D Alcoholic iodine solution
dehydration. The doctor has immediately administered him antidote in poisonings by bismuth compounds, E Sodium hydrocarbonate
intravenous infusion of Sodium chloride. At what situation is A. *Unithiolum Patient with abscess of the cut wound applied to the
necessary to use this drug? В. Nalorphine traumatological department. Doctor for
A. *Cholera С. Bemegridum the cleaning of the wound from the pus washed it
B. Toxicosis of pregnancy D. Naloxone with 3% hydrogen peroxide. Foam was
C. Osteoporosis E. Methylen blue
absence. What caused the absents on the drug
D. Edemas 4. A patient after drinking unknown liquid was admitted to a activity?
E. Arthritis hospital with complaints of stomachache, pain in gullet and A *Inherited insufficiency of catalase
11. Convulsions and laryngospasm have developed at the patient diarrhea with little amount of blood. Under examination hyperemia
of throat mucous membranes, gums' bleeding, lymphatic nodes B Low concentration $H_{2}O_{2}$
with hypoparathyrosis. Laboratory examination revealed
significant decrease of calcium ions concentration in the blood enlargement and metallic aftertaste were revealed. Within 2-3 days C Inherited insufficiency phosphatdehydrogenase of
and slight elevation of pH. Which drug should be introduced for renal insufficiency was developed. Determine the agent which erythrocyte
correction of metabolic alkalosis? caused named above symptoms: D Shallow wound
A. *Ammonium chloride A. *Salts of heavy metals E Pus in the wound
B. Trisamine B. Furacilinum For the preparation of a patient's burn skin surface a
C. Magnesium oxide С. Ethylic alcohol certain medication was used. Its
D. Aluminium hydroxide D. Boric acid antiseptic action is provided by free oxygen that
E. Sodium hydrocarbonate E. Atropine segregates in presence of organic
12. Which of plasma substitutes listed below circulates in the 5. After treatment with bismuth preparation, a patient with syphilis substances. Choose the right answer:
blood for a long time? developed symptoms of kidney insuffuciency and gray strains on A *Potassium permanganate
A. * Rheopolyglucinum mouth mucous membranes. Indicate a drug a doctor has to use as
specific antidote in the case:
B Furacilin
B. 5% glucose solution C Chlorhexidine
С. 0.9% solution of Sodium chloride A. *Unithiol
 13
D Boric acid A. *Boric acid A. * Aliphatic agents
E Sodium bicarbonate B. Nicotinic acid B. Aromatic agents
C. Folic acid C. Spirits
D. Ascorbic acid D. Halogen-maintained agents
1. The patient addressed to the doctor in relation with trauma of E. Dehydrocholic acid E. Detergents
the foot. The foot was bandaged with a dirty gauze bandage, 6. Specify the antiseptic which is used for disinfection of operation
impregnated with purulent discharges. Attempt to take off a 12. 70% solution of aethyl spirit was used by a surgeon for
field and surgeon's hands.
bandage for survey and processings of a wound invoked an cleaning his hands before operation. Explain the mechanism of
A. *70% solution of ethyl alcohol
acute pain as the bandage had stuck to wound surface. Choose action of the antiseptic drug:
B. Furacilinum
an antiseptic which will facilitate taking off of a bandage and C. Ethonium A. *Protein dehydration of microbes protoplasm
will mechanically clear a wound of mud and pus. D. Potassium permanganate B. Blockade of sulfhydryl groups of enzymes
A. * Hydrogen peroxide E. 95% solution of ethyl alcohol C. Oxidation of organic components of microbes 'protoplasm
В. Aethacridinum lactate D. Interaction with aminogroups of protoplasm proteins of
7. Determine the following drug: it contains an halogen, exerts microbes
С. Aethonium
P. Potassium permanganate antimicrobial and deodorizing action, is used for disinfection of E. Interaction with hydroxilic groups of microbes enzymes
non-metal instruments, as an antiseptic - for processing of hands
E. Furacilinum
A.*Chloraminum 13. A doctor used 5% spirituous solution of iodine for cleaning of
2. The patient addressed to the doctor with complaints of B. Hydregen peroxide operation field. Indicate its mechanism of action:
pustular pimples on the skin of the face. In bacteriological C. Formaldehyde A. *Interaction with amino groups of microbes 'proteins that
analysis of contents of pustules staphylococcus aureus was D. Phenol disposes to their denaturation
found and the diagnosis of staphylococcal pyodermia was E. Resorcinum B. Dehydration protoplasm's proteins
given. Choose the most efficient drug from the listed antiseptics C. Bound to enzymes' sulfhydric groups
for local use in pustular pimples. 8. A patient was admitted into the emergency department in
D. Formation of albuminates
relation with acute poisoning - by mistake he drank mercury
A.* Brilliant green E. inhibition of dehydrogenase
dichloride solution. The patient complained of severe pain in the
B. Ethyl alcohol
oral cavity, along the esophagus and in the epigastric area, 14. A female suffers from varicose veins dilatation of lower
С. Chlorhexidinum
hypersalivation, fatigue, tachycardia. Specify the agent which extremity which is complicated by ulceration on ankle. The ulcer
P. Potassium permanganate
would neutralize the absorbed mercury binding to it. is accompanied by local hyperemia and itching around and
E. Aethacridinum lactate
A. *5% solution of unithiolum intramuscularly discharges pus with staphylococci. An antiseptic ointment from
3. A patient addressed to г ophthalmologist with complaints of B. Methylene blue with 5% glucose solution intravenously the group of detergents was administered for treatment. After
eye discomfort, discharge of purulent exudate, disorders of solution of sodium treatment all of the symptoms are diminished. Indicate the drug:
vision. Specify the antiseptic available for rinsing of the eyes. C. 4% solution of sodium carbonate intravenously A. * Ethonium
A. *Silver nitrate D. 2% solution of sodium nitrite intravenously B. Furacilhium fnitrofuran)
B. Lugol's solution E. 2% solution of furosemide С Viride nitens (brilliant green)
С Potassium permanganate D. Aethacrydine lactate
P. Salicylic acid 9. All antiseptics possess ail following properties except:
E. Potassium permanganate
E. Ammonium solution A *Selective antimicrobic action
B. Versatile antimicrobic action SULFONAMIDES AND OTHER SYNTHETIC
4. In a patient with varicose dilation of veins the trophic ulcer С. Bactericidal action ANTIBACTERIAL AGENTS
of the leg developed. The bacteriological examination of the D. Highly toxic for human Patient with pneumonia has intolerance to
ulcer discharge revealed Staphylococcus infection. For the E. Are not introduced parenterally
antibiotics. Which of the conbined sulfanilamide
local treatment of the ulcer an antiseptic in the form of 10. Chloramine possesses all following effects, except: medicines should be prescribed to the patient?
ointment from the group of detergents was administered. A. *Antiallergical
Specify it. A *Biseptol
B. Deodorization
A. *Ethonium B Aethazol
C. Antiseptic
B. Brilliant green D. Spermicidal C Natrium sulfacyl
С Furacil/inum D Streptocid
E. Fading
D. Potassium permanganate E Sulfadimethoxine
E. Ethacridini iactas 11. Formaldehyde solution is used for disinfection of non-metallic A 7 year old child is ill with bronchitis. It is necessary
5. Which acid possesses the properties of an antiseptic? surgical tools. Indicate the correct name of group of formaldehyde:
to administer him an antibacterial
 14
drug. What drug of fluoroquinolone group is B. Phthalazolum cough reduced. The treatment was discontinued and the patient
\textbf{CONTRA-INDICATED} at this age? С. Urosulfanum turned back to work. Next day he/she felt much worse, fever and
D. Sulfadimezinum cough were developed again, that is why the patient had to be
A *Cyprofloxacin E. Biseptoium examined by the physician, indicate please which principle of
B Ampicillin chemotherapy was disobeyed by the patient:
C Amoxicillin 5.Specify the combined sulfonamide agent.
A. *Duration of treatment
D Sulfadimethoxine A. *Biseptolum
B. Combined usage of agents
E Ampiox B. Ethazolum
C. The earliest chemotherapy beginning
С. Sulfacylum-natrium
Gonorrhoea was revealed in the patient on D. Effective agent choice based on clinical and
D. Sulfadimethoxinum
bacterioscopy of the smear from urethra. Taking into bacteriological diagnosis
E. Streptocidum
account that medecines for gonorrhoea are E. Optimal selection of dosage, timing and
fluorquinolones, patient should be prescribed: 6. A patient visited a physician with complaints of painful and introduction ways of agent
frequent urination, pain in the lower part of the back. After
A *Ciprofloxacin 10. Patient with pneumonia was treated by injections of
laboratory and bacteriologic examination of the urine (it revealed
B Furazolidone antibiotic. Determine the type of chemotherapy:
gram-positive cocci, Proteus, acute cystitis and urethritis were
C Fluorouracil diagnosed. Specify the agent that should be administered taking A. *Causal treatment
D Urosulfan into account the localization of its action. B. Substitute treatment
A. *Nitroxlinum C. Preventive treatment
E Cefazoline
B. Ethazolum D. Symptomatic treatment
C. Biseptoium E. Pathogenic treatment
1. The doctor administered Sulfadimezinum in tablets to the
patient with bacterial infection, and advised to take the drug with D. Sulfadimezinum 11. Duration of sulfonamide agents' activity depends on:
alkaline mineral water. Indicate the purpose of the given E. Furasolidonum
A. *Affiliate activity with proteins of blood or/and reabsorption
reference. 6. Specify the antimicrobial drug from the group of 8-oxiquinolirte in renal canaliculi
A. * For prophylaxis of crystallization of acetylated derivatives. B. Aptitude of enterohepatic circulation
derivants of the drug in renal tubules A. *Nitroxolinum С. Speed of absorption in GIT
B. For prolongation of action B. Biseptoium D. Level and speed of metabolic biotransformation in liver
С For reducing of the irritative action on the stomach C. Nalidixic acid E. All named above
D. For neutralization of HCl of a gastric juice D. Ciprofloxacinum 12. After antimicrobial treatment of pneumonia within 8 days
E. For shift of blood pH in the alkaline side E. Furaginum patient developed painful urination, pain in kidneys area, the
2. A 37 year-old patient was admitted to an infectious diseases 7. Specify the antimicrobial drug from the group of nitrofurans. urine has brown. Indicate the drugs group that used in the case:
hospital with the diagnosis of dysentery. Indicate the drug which A. *Furaginum A. *Sulfonlamide
should be appointed to the patient? B. Biseptoium B. Lincomycin
A. * Ciprofloxacin С Nalidixic acid C. Β- lactam antibiotic
B. Erythromycin D. Nitroxolinum D. Aminoglycosides
С. Oxacillinum E. Ciprofloxacinum E. Cephaiosporines
D. Phenylsalicylate
E. Imodium 8. Specify the antimicrobal drug from the group of 13. After long-term treatment by antibiotics at the in-patient
fluoroquinolones. department a patient developed dyspeptic syndrome.
3. Specify the sulfonamide drug which is poorly absorbed in the A. *Ciprofloxacinum Investigation of stool revealed diminished amount of
intestine and is used for the treatment of intestinal infections. B. Biseptoium Bifidobacterium and Bacillus coli. What is the reason of present
A. *Phthalazolum С. Nalidixic acid illness?
B. Ethazolum D. Nitroxolinum A. *Disbacteriosis
С. Sulfadimethoxinum E. Furaginum B. Enteric colibacillosis
D. Sulfadimezinum C. Pseudomembranous enterocolitis
E. Sulfacylum-natrium 9. During examination in out-patient department a physician
D. Toxic action of the agents
identified pneumonia and- prescribed in-patient treatment by
4. Specify the sulfonamide agent for the treatment of E. Acquisition of nosocomial infection
ampicillin and cefalexin. However, the patient started treatment at
conjunctivitis. home with the same antibiotics, dosage and timing prescribed by 14. Indicate an antibacterial agent from the group of
A. *Sulfacylum-natrium the doctor. Within three days the sick person felt better, fever and fluoroquinolone:
 15
A. *Ciprofloxacin С. Clindamycinum B. Tetracycline
B. Nalidix acid D. Cefazolinum C. Laevomycetine
С. Nitroxolin E. Chloramphenicol D. Clindamycin
D. Furosemide E. Cefazolin
4. Specify the main antibiotic for the treatment of diphtheria.
E. Biceptol 17. Cephalosporines possess following properties,
A. *Erythromycinum
except:
B. Laevomycetinum
ANTIBIOTICS (I) A. *Detergent activity
С. Cefazolinum
A 60-year-old patient was admitted to the surgical D. Gentamycinum B. Mechanism of action linked to infringement of microbe
department because of infection caused E. Tetracyclinum s membrane synthesis
by blue pus bacillus (Pseudomonas aeruginosa) 7. Specifу the group of antibiotics whose mechanism of action is C. Bactericidal activity
which is sensative to penicillin antibiotics. connected with inhibition of synthesis of bacterial ceil wall. D. Distinguished from penicillines by higher persistence
Indicate which of the given penicillins has marked A. *Penicillins toward β-lactamase
activity to the Pseudomonas B. Macrolides E. Distinguished from penicillines by spectrum of
antimicrobial activity
aeruginosa? C. Tetracyclines
A *Carbenicillin disodium D. Aminoglycosides 18. 56-years old male was admitted to a hospital with pneumonia.
E. Lincosamides It is known he suffers from hay fever and seasonal vasomotor
B Benzylpenicillin
rhinitis. What drug should be administered in the case?
C Phenoxymethylpenicillin 8. Specify the most typical side-effect of penicillins.
A.*Allergic reactions A. *Cefazolin
D Oxacillin B. Benzylpenicillin
E Methicillin B. Agranulocytosis
C. Anemia С. Bicillin
A 19 year old woman suffers from primary syphilis. D. Decrease of audition D. Oxacillin
Doctor administered her complex E. Hepatotoxic influence E. Ampiciliin
therapy that includes benzylpenicillin sodium salt. 19. 14-years old boy developed acute pneumonia in low lobe of
What is the mechanism of action of this 9. Specify the antibiotic from the group of semisynthetic penicillins.
A. *Ampiciilinum the right lung. The agent in sputum analysis was resistant to
drug? penicillin. Choose the drug for treatment in this case:
B. Phenoxymethylpenici/linum
A *It blocks synthesis of peptidoglycan of microbal C. Benzylpenicillinum natrium A. Gentamycin
membrane D. Benzylpenicillinum kalium B. Laevomycetine
B It blocks synthesis of cytoplasm proteins E. Benzylpenicillinum novocainum С. Streptomycin
C It blocks thiol enzymes D. Tetracycline
14. Indicate a drug group which oppresses synthesis of cell E. *Cefazolin
D It blocks RNA synthesis membrane components:
E It blocks DNA synthesis A. *Penicillines 20. Determine drug by following: it oppresses of protein
A patient with bacterial pneumonia was prescribed B. Tetracyclines synthesis by microbes ribosomes because of inhibition of
benzylpenicillin. What is the mechanism C. Aminoglycosides peptidtranslocase, belongs to reserve macrolide, causes side
of its antibacterial effect? D. Lincosamides effects relatively seldom.
E. Macrolides A. *Erythromycin
A *Inhibition of synthesis of microorganism wall B. Sygmamycin
B Inhibition of intracellular protein synthesis 15. Drug with β-lactam ring was prescribed to a patient with С. Tetraolean
C Abnormal permeability of cytoplasmic membrane streptococci gums inflammation. Indicate this drug: D. Azithromycin
D Inhibition of SH-groups of microorganism enzymes A. *Benzylpenicin E. Tetracycline
B. Rifampicine
E Antagonism with p-amino-benzoic acid 23. A patient with diminished hearing has severe bacillary
C. Erythromycin
D. Streptomycin sulfate infection. Which drug group is contradicted to the patient?
E. Laevomycetine A. *Aminoglycosides
3. A patient was delivered to the surgical department with B. Peniciltines
anaerobic gangrene. Specify the antibiotic of first choice for the 16. A patient was admitted to a hospital with diagnosis: gaseous C. Cephalosporines
treatment of this infection. gangrene. Drugs for its treatment are divided on two groups: basic D. Tetracyclines
A. *Benzylpenicillinum natrium and reserve. Indicate the basic antibiotic: E. Rifampicines
В. Tetracyclinum A. *Benzylpenicillin natrium
 16
24. Patient with acute appendicitis, was admitted to a surgical B. Bicilline-3 E Ampicillin
department. Appendectomy was performed. During ten days after C. Benzylpenicillin A patient suffers from severe postoperative
operation patient received an antibiotic. After a while lowering of D. Polymixine M pseudomonadous infection. What of the following
hearing were revealed. Indicate drug group with the same side E. Ampicillin
antibiotics should be administered in this case?
effects:
2. A patient started to complaint of worsening of audition after A *Amicacin sulfate
A. *Aminoglycosides
treatment with antibiotic because of purulent complication after the
B. Tetracyclines B Benzylpenicillin
surgical operation. Specify the group of antibiotics which posses
C. Polymyxines
ototoxic activity. C Cephazolin
D. Macrolides D Erythromycin
A. * Aminoglycosides
E. Penicillines E Doxycycline
В Penicillins
25. Determine the drug for treatment infections of bones that able С. Tetracyclines
to penetrate to bone tissue and bone marrow: D. Polymyxins 1. The patient with the diagnosis of cholera was admitted to
A *Lincomycin the infection diseases hospital. Specify a group of antibiotics
E. Macrolids
В. Benzylpenicillin of the first choice for treatment of this disease
С. Bicitlin-3 A. *Tetracyclines
D. Gentamycin ANTIBIOTICS (II). ANTIFUNGAL AGENTS B. Aminoglycosides
E. Synthomycinum A patient underwent appendectomy. In the С. Penicillins
postoperative period he has been taking an D. Macrolids
29. A patient with diagnosed streptococcal bronchopneumonia
antibiotic. The patient complains about hearing E. Cephalosporines
after treatment with an antibiotic suffers from allergic symptoms.
Determine the drug: impairment and vestibular disorders. What 5. A woman addressed to a dentist with complaints of teeth
A. *Benzylpenicillin-natrium (penicillin G sodium) group of antibiotics has such by-effects? destruction in her little child. It was revealed that during
B. Tetracycline A *Aminoglycosides pregnancy the woman took antibiotics. Specify the group of
C. Gentamycin B Penicillins antibiotics that could cause these side-effects.
D. Laevomycetineum (chloramphenicol) C Tetracyclines A. *Tetracyclines
E. Doxicycline B. Macrolides
D Macrolides
30. Infectious agent determined by lab tests is known to be E Cephalosporins C. Penicillins
sensitive to third generation cephalosporins. Choose the drug for D. Cephalosporins
treatment: E. Aminoglycosides
A patient has herpetic rash. What medication should be
A. Cefazolin 6. An antibiotic was administered to a patient suffering from
administered?
B. Cefalexin abdominal typhoid. Soon there was general improvement, but on
С Cefalotin A *Acyclovir the 2nd week after the treatment the patient had elevation of body
D. *Cephtriaxone B Gentamycin temperature, signs of tonsillitis, and rashes on mucous
E. Cefaloridin C Clotrimazole membranes of lips & nose. In laboratory examination of
31. A patient with bacterial pneumonia was treated by the D Benzylpenicillin sodium salt discharges, Candida fungi were found. The blood analysis
erythromycin which acts on microbes by interaction with their E Biseptol revealed leukopenia and agranulocytosis. Which antibiotic could
free 50S subunits of ribosomes. What process does this drug cause these complications?
block? A. *Laevomycetinum
Patient was admitted to the infection unit with B. Tetracyclinum
A. *Proteins' synthesis
B. RNA synthesis
diagnosis of bacterial dysentery. On laboratory studies С. Polymyxins
C. DNA synthesis it was revealed that causative element is sensative to D. Gentamycinum
D. Lyposynthesis the many antimicrobial medicines, but patient has E. Cefazolinum
E. Polysaccharides' synthesis anemia. What medicine is contra-indicated to the 10. Specify the group of antibiot ics whose mechanism of action
26. An antibiotic with ability to penetrate to bones tissue was
patient? involves inhibition of protein synthesis by microorganisms.
prescribed to 30 years old patient with osteomyelitis. After three A *Levomycetin A. *Tetracyclines
B. Penicillins
weeks of using it the patient felt much better. Determine the B Phthalazol
drug: С. Cephalosporins
C Furazolidone D. Monobactams
A. Lincomycin D Enteroseptol E. Polymyxins
 17
11. In the treatment with wide-spectrum antibiotics some E. Benzylpenicillin D Rifampicin
complicaions, including candidiasis may occur. Specify the agent E Streptomycin
28. Considerable number of Candida albicans was revealed on
for the treatment of candidiasis. A patient was diagnosed with active focal pulmonary
cytological investigation of smear of 25 years-old woman with
A. *Ketoconazole
exacerbation of chronicle vaginitis. Which drug should be tuberculosis. What drug should be
В Amphotericinum B
C. Griseofulvinum
prescribed? prescribed in the first place?
D. Gramicidinum A. *Nystatin A *Isoniazid
B. Amphotericine
E. Undecinum B Sulfalen
C. Miconazole
12. A patient with dermatomycosis took antifungal agent which D. Clotrimazole C Cyclocerine
was able to be accumulated within the cells producing keratin E. Metronidazole D Ethionamide
(skin, nails, hairs), in several clays the patient visited the 32. An antibiotic for treatment of enteric fever was administered to E Ethoxide
physician complaining of headache, desorientation. Specify the a patient. Clinical recovery was achieved, but within 2 weeks the
appointed antibiotic. patient developed symptoms of quinsy, fever, rashes at mucous 1. The patient who had been suffering from tuberculosis was
A. *Griseofulvinum membranes of lips and nose. Blood test revealed diminished amount treated with Isoniazidum. After a while the patient began to
B. Levorinum of WBC and granulocytopenia. Choose an antibiotic which can complaint of muscle weekness, decrease of skin sensitivity,
С. Amphotericinum В cause these side effects: impairment of vision and motor discoordination. Indicate the
D. Mycogeptinum vitamin's drug which should be administered to eliminate the
A. Tetracycline
E. Nystatinum specified phenomena?
B. *Laevomycetinum (chloramphenicol)
С. Роlymyxine М sulfate A. * Pyridoxin (B6)
13. After long-term treatment with tetracyclinum a patient was B. Retinol (A)
D. Cefazoline
hospitalized in relation, with aphthous stomatitis. During С. Ergocalciterol (D)
E. Gentamycine
laboratory examination the Candida fungi were identified. D. Cyanocobatamin (B12)
Specify the agent available for the treatment of candidiasis. 33. Tetracycline was administered PO for treatment of acute E. Ascorbinic acid (C)
A. *Nystatinum purulent sinusitis. What antimycotic drug should be administered to
В. Furazolidonum a patient to prevent candidiasis? 2. Indicate the drug which is used for intranasal dropping with the
С. Griseofuivinum purpose of prophylaxis of infuenza.
A. Griseofulvin
D. Amicazolum A. * Interferon
B. Levamisole
E. Cefalexinum B. Remantadinum
C. Furazolidone
С. Ampicillinum
21. Determine drug with wide spectrum of antibiotic activity, a D. Ciprofloxacin
D. Aciclovir
basic antibiotic agent of treatment enteric fever and other E. *Nystatin
E. Paracetamolum
salmonellosises and possesses following side effects: oppresses 34. After taking tetracycline for a long period of time, patient
of bone marrow activity, disbacteriosis and dyspeptic disorders: developed candidiasis of mucous membranes of mouth. Which drug 3. Specify the antibiotic available for the treatment of
A. *Laevomycetine should be used for treatment? tuberculosis.
B. Phthalazolum A. *Nystatin A.*Rifampicinum
С. Benzylpenicillin natrium B. Griseofulvin B. Tetracyclinum
D. Neomycin sulfate С. Nitrofungine С. Ampici/linum
E. Tetracycline D. Nitroxoffne D. Erythromycinum
22. Which drug is used for treatment of enteric fever? E. Furadon/ne E. Lincomycinum
A. *Laevomycetine 4. Specify the antituberculous agent which inhibits synthesis of
B. Ampicillin ANTITUBERCUFOUS, ANTIVIRAL AND ANTISYPHILITIC
mycolic acids by Mycobacterium tuberculosis.
C .Cefalexin AGENTS.
A. *Isoniazidum
D. Benzylpenicillin A patient suffers from pulmonary tuberculosis. During
treatment neuritis of visual nerve B. Ethambutolum
E. Erythromycin C. Streptomycinum
arose. What drug has caused this by-effect? D. Cycloserinum
27. Deteirmine drug for treatment of candidiasis:
A. *Nystatin A *Isoniazid E. PAS
B. Kanamycin B Ethambutol 5. Indicate the most effective synthetic antituberculous drug.
C. Tetracycline C Kanamycin A. Kanamycinum
D. Erythromycin
 18
B. Streptomycinum tuberculosis suffers acute pain of the right big toe, accompanied by D. Streptomycin
С. Rifampicinum swelling and slight fever. The gouty arthritis was diagnosed and E. PAS
D. PAS high serum uric acid level was found. Which of the following
17. After treatment by antituberculous drugs during three month,
E. *Isoniazidum antituberculos drug is known for causing high uric acid levels?
a patient developed daltonism, reduced ability to distinguish red
6. A patient, 60 years old had been treated for tuberculosis for a A. *Pyrasinamide and green colors. Which antituberculous agent can cause this
long time. Recently he began to omplain of decrease in audition, B. Cycloserine side effect?
which drug should be contraindicated? С. Rifampicine
A *Ethambutol
D. Thioacetazone
A. *Streptomycinum B. Streptomycin
E. Aminosalicylic acid
B. Ftivazidum С. PAS
С Ethambutolum 12. Patient has inherited of acetyl-transferase insufficiency. Which D. Rifampicine
D. Isoniazidum drugs can cause severe intoxication in this case? E. Cycloserine
E. Rifampicinum A. *Hydrazids of isonicotinic acid
B. Barbiturates 18. Determine drug for AIDS treatment with following
7. Drugs of which group must be administered first of all to a girl mechanism of action: it is able to be phosphorilizated in cells and
С. Antibiotics-tetracyc/ines
1.5 years old in relation with acute herpetic, stomatitis during transformed to triphosphate, and then it inhibits viral
D. β-adrenoblockers
rash period? transcriptase and impede of DNA synthesis from viral RNA.
E. Nitrates
A. *Antiviral agents A. *Zidovudine
B. Antiallergic agents 13.Which antituberculous drug from the following oppresses B. Saquinavir
С. Antibiotics transcription DNA to RNA? С. Indinavir
D. Antiseptics A. *Rifampicine D. Ritonavir
E. Keratoplasty B. Isoniazid E. Virasept
С. Streptomycin
8. Specify the agent which could be used for the prevention of D. Ethionamide 19. After treatment by the antiretroviral drug from the group of
influenza during epidemic period. E. PAS nucleosides within six month a patient with AIDS developed
A. *Remantadinum reducing amount of RBC, neutrophilic cells and platelet cells in
B. Biseptolum 14. Patient with leprosies developed hypopigmentic rash with the blood. Indicate the agent that is able to cause these side
С. Ampicillinum absence of perception in its location. An antibiotic that is the basic effects?
D. Anaiginum antituberculous agent was prescribed. Indicate this drug:
A. *Zidovudine
E. Paracetamolum A. *Rifampicine
B. Sackvinovir
B. Amoxicillin
9. In the newborn department of a hospital there was sudden С. Acilovir
С. Erythromycin
increase of acute respiratory disease caused by venous types of D. Valaciclovir
D. Nitroxoli
viruses. To prevent spread of the infection it was recommended E. Remantadine
E. Cefazolin
to use human leukocytic interferons. Specify the available way of 20. 19-Years old patient with primary syphilis receives complex
introduction in this case. 15. After treatment of patient suffering from tuberculosis, his vision treatment by benzylpenicillin natrium. What is its mechanism of
A. *Intranasal worsened rapidly, visual fields were narrowed. Determine the drug action?
B. Subcutaneous. which caused these side effects:
A. *Blockade of murein synthesis in cell walls
С Intramuscular A *Ethambutol B. Blockade of protein synthesis in cytoplasm
D. Peroral B. Isoniazid С. Blockade of tiotic groups of enzymes
E. Inhaled. C. Kanamycin sulfate D. Blockade of RNA synthesis
D. Ethionamide E. Blockade of DNA synthesis
10. A woman 25 years old was hospitalized for treatment of
E. Rifampicine
syphilis. Specify one of the main antibiotics for treatment of this 21. A patient has been suffering from tuberculosis associated
disease. 16. 60-Years old male, with diagnosed tuberculosis long time ago, with intracellular location of mycobacterium for a long period of
A. *Benzylpenicillinum natrium timely receives antituberculous treatment. He developed neuritis of time. What drug must be included in complex treatment?
В Erythromycinum nervous facials. Which drug can cause this side effect and should A. Rifampicine
C. Tetracyclinum be accepted from the therapy: B. *Isoniazid
D. Lincomycinum A *Ethambutol C. Ethambutol
E. Vancomycinum B. Isoniazid D. Ethionamide
С. Rifampicine E. Natrium paraaminosalicilate
11. A 35-year-old man under the treatment for pulmonary
 19
22. A patient known to be treated of pulmonary tuberculosis been in a forest and drunk from an open water В. Sulfadimezinum
noticed that his lachrymal liquid and urine became red. What reservoir. Laboratory analyses enabled to C. Chingaminum
drug is able to develop such side effect? make the following diagnosis: amebic dysentery. What D. Chloridinum
A. *Rifampicine E. Monomycinum
is the drug of choice for its
B. Isoniazid 2. Mother addressed to the pediatrician with the child who
C. Ethionamide
treatment?
complained of strong itch in the region around the anus, pain
D. Streptomycin sulfas A *Metronidazole intensified at night. After investigation of feaces the diagnosis of
E. Ethambutol B Furazolidonum enterobiasis was given. Indicate the drug which should be
23. 39-years-old patient with pulmonary tuberculosis received C Levomycetin administered.
effective complex treatment composed of 3 antituberculous agents D Phthalazol
including Steptomycin sulfate. What is its mechanism of action? A. *Levamisolum
E Emetine hydrochloride B. Trichlorophenum
A. *Blockade of proteins synthesis
Systemic amebiasis with involvment of intestines, liver, С. Phenasalum
B. PABA anti-metabolite
C. Blockade of RNA synthesis lungs was diagnosed in a D. Ditrazinum
D. Inhibition of DNA replication 52-year-old patient. What drug should be prescribed? E. Aminoacrichinum
F. Inhibition of mycolic acids synthesis A *Metronidasol 3. Indicate the antimalarial agent which is active against
24. A patient with primary syphilis has allergy to B Quiniofone paraerythrocytic forms of Plasmodium.
benzylpenicillin. What drug can be prescribed in the case? C Tetracycline А *Рrimachinum
A. *Erythromycin D Quingamine В Chingaminum
B. Amoxicillin С. Galochinum
E Enteroseptol
С. Amoxiclav D. Hydroxychlorochinum
A patient consulted a doctor about bowels disfunction. E. Aminoacrichinum
D. Carbenicillin
E. Lincomycin
The doctor established symptoms of 4. Specify the drug which is used in amebiasis of any localization
duodenitis and enteritis. Laboratory examination of pathological process.
30. 25-years old woman was admitted to a hospital with helped to make the following diagnosis: A. *Metronidazolum (Trichopolum)
diagnosed syphilis. Indicate the main antibiotic for her
lambliosis. What medication should be administered? B. Chingaminum
treatment: C. Emetinum hydrochloridum
A. *Benzylpenicillin natrium (penicillin G sodium) A *Metronidazole
D. Chiniophonum
B. Tetracycline B Erythromycin E. Tetracyciinum
С. Lincomycin C Monomycin
5. A patient visited a physician with complaints of bowel
D. Vancomycin D Chingamin
E. Erythromycin dysfunction. After laboratory examination the diagnosis of
E Tetracycline lambliasis was made. Specify the drug that should be used.
A patient ill with amebiasis was prescribed a certain A. *Metronidazolum (Trichopolum)
drug. The use of alcohol together with B. Tetracycilinum
ANTIPROTOZOAL AND ANTHELMINTIC AGENTS.
this drug is contra-indicated because the drug inhibits С. Trichomonacid
A patient consulted a stomatologist about purulent
metabolism of ethyl alcohol. What D. Monomycinun
inflammation of his gums. What drug will E. Chingaminum
drug is it?
be the most effective if it is suspected that a
A *Metronidazole 6. During summer vacations a student from tropical country
causative agent is an anaerobe?
B Reserpine developed tertian malaria. After recovery he turned back to
A *Metronidazole Ukraine for study extension. In January an exacerbation was
C Clonidine
B Gentamicin developed, it is known from past history of disease that drug
D Diazepam acting on paraerythrocytic plasmodium malariae for prevention of
C Oxacillin sodium
E Aminazine relapse was not prescribed. Indicate the drug:
D Co-trimoxazole
E Nitroxoline A. Chingaminum
1. A female patient addressed to gynecologist with complaints of B. Halochin
A 30-year-old patient complains about having undant discharges from vagina with pleasant smell. After С. Hydroxychloroquine
abdominal pain and diarrhea for five days; bacteriological vestigation the diagnosis of trichmo-•sis has been D. Amodiaquine
body temperature rise up to $37,5^oC$ along with given. Specify the ug which should be administered. E. *Primaquine
chills. The day before a patient had A. * Metronidazolum (Trichopolum)
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7. Patient addressed to a physician to get a drug for prevention of C. Myelosanum it some grey spots turned up on the mucous
malaria. Indicate the drug: D. Mercaptopurine membrane of the oral cavity; nephropathy
A. *Primaquine E. Hexestrolum symptoms were also present. What drug should be
B. Clotrimazole used for treatment of bismuth
2. Determine a drug for treatment of lympholeukosis:
С. Mebendazole
A. *Embichinum intoxication?
D. Furazolidone
E. Fenasal B. Phthoruracilum A *Unithiol
C. Depostat B Methylene blue
8. What is the mechanism of anthelmintic action of levamisole? D. Diethylstilbestrol
A. *Oppression ot succinate dehydrogenase, ATPase
C Naloxone
E. Phenobolinum
В. Oppression of MAO D Bemegride
3. A drug belongs to the group of anti-metabolites being an E Nalorphine
C. DNA synthesis damage antagonis causes impairment of purines' synthesis, and thus lead to
D. Cholinesterase activation diminishing of nucleic acids' synthesis. Determine the drug:
E. Oppression of N-acetyltransferase A. *Methotrexate
9. A drug is administered for prevention and treatment of malaria, B. Mercaptopurine
treatment of amebiasis and diseases of connective tissue. Indicate C. Phthoruracilum (fluorouracil)
the drug. D. Cytarabine
A. *Chingaminum (chloroquine) E. Cispiatine
B. Tetracycline 4. Antitumoral drug from the group of antimetabolites is used for
C. Metronidazole treatment of leucosis of children and cancer of adults. Determine
D. Erythromycinum the drug:
E. Quinine A. *Methotrexate
10. A drug was administered to a patient with ascaridosis. It is B. Sarcolysinum
known to have influence on immune system, and is used as С. Colchamine
immunological modulator. Indicate the drug! D. Rubomycin
A. *Levamisole E. Prednisolonum
B. Piperazine
С. Pyrantel THE TREATMENT OF ACUTE POISONONGS BY DRUGS
D. Phenasaium (niclosamide) A patient with acute morphine poisoning was delivered
E. Praziquantel to a hospital. What specific narcotic
11. A patient complaints of nausea, vomiting, loss of appetite. antagonist should be chosen in this case?
After investigation of stool ascaridosis was revealed. A drug A *Naloxone
with immune modulation activity was prescribed for single B Paracetamol
usage. Indicate the drug: C Methacin
A. *Levamisole D Digoxin
B. Mebendazole
E Unithiol
С. Pyrantel
D. Naphtamonum Patient with mercury poisoning was admitted to the
E. Piperazine toxicological department from the
chemical industry. What medicine should be used?
A *Unithiol
ANTITUMOAL AGENTS B Isonitrozin
C Naloxone
1. The antitumoral agent from the group of antimetabolites D Activated carbon
(antagonists of folic acid) was administered to the patient E Enterosorbent
with acute leucosis. Indicate this drug. A patient suffering from syphilis has been treated with
A. *Methotrexatum
bismuth preparations. As a result of
B. Fluorouracil