Item C131A. Diagnosis of Gross Hematuria.: Clues/History Possible Diagnosis

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Item C131A. Diagnosis of gross hematuria.

Clues/History Possible Diagnosis


Lower tract symptoms (dysuria, UTI
urgency, frequency, suprapubic pain)
Recent illness (pharyngitis, impetigo, Postinfectious glomerulonephritis
viral illness)
Abdominal pain UTI, HSP, crystalluria/stone
Concurrent illness IgAN
Extreme exertion, influenza Rhabdomyolysis
Arthralgias HSP, SLE
Diarrhea (± bloody) HUS
Cough, hemoptysis Vasculitis
Hearing loss Alport disease
Nail or patellar abnormalities Nail patella syndrome
Sickle cell disease Glomerulonephritis, papillary
necrosis
Drugs (diuretics, cyclophosphamide) Stones, hemorrhagic cystitis
Birth asphyxia Renal vein thrombosis
Physical Findings
Suprapubic pain UTI
Flank pain IgAN, stones, renal vein thrombosis,
pyelonephritis
Rash (purpura, petechiae) HSP, SLE, HUS, bleeding dyscrasia,
abuse
Edema Glomerulonephritis, nephrotic
syndrome
Abdominal mass Wilms tumor, hydronephrosis, cystic
kidney disease
Conjunctivitis, pharyngitis Adenovirus (hemorrhagic cystitis)
Meatal stenosis Infection, trauma
Nail or patellar abnormalities Nail patella syndrome
Family History
Hematuria Benign familial hematuria, thin base-
ment membrane disease
Hearing loss or prominent history of Alport syndrome
renal failure in males
Cystic kidney disease Autosomal dominant polycystic
kidney disease
Nail/patellar abnormalities Nail patella syndrome
Sickle cell disease or trait

HSP=Henoch-Schönlein purpura, HUS=hemolytic-uremic syndrome, IgAN= immunoglobulin A


nephropathy, SLE=systemic lupus erythematosus, UTI=urinary tract infection.

Reprinted with permission from Massengil SF. Hematuria. Pediatr Rev.2008;29(10):345

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