The document discusses the significance of blood cell production, known as hematopoiesis. It notes that hematopoiesis is important to study as it provides knowledge about stem cell biology and diseases. It also explains that blood cell production must occur continuously to replace old blood cells. The reflection then summarizes what was learned from watching an educational video about hematopoiesis. It describes the process starting from hematopoietic stem cells differentiating into various blood cell types, and how different cytokines regulate blood cell production levels. A concept map further illustrates the hematopoiesis process.
The document discusses the significance of blood cell production, known as hematopoiesis. It notes that hematopoiesis is important to study as it provides knowledge about stem cell biology and diseases. It also explains that blood cell production must occur continuously to replace old blood cells. The reflection then summarizes what was learned from watching an educational video about hematopoiesis. It describes the process starting from hematopoietic stem cells differentiating into various blood cell types, and how different cytokines regulate blood cell production levels. A concept map further illustrates the hematopoiesis process.
The document discusses the significance of blood cell production, known as hematopoiesis. It notes that hematopoiesis is important to study as it provides knowledge about stem cell biology and diseases. It also explains that blood cell production must occur continuously to replace old blood cells. The reflection then summarizes what was learned from watching an educational video about hematopoiesis. It describes the process starting from hematopoietic stem cells differentiating into various blood cell types, and how different cytokines regulate blood cell production levels. A concept map further illustrates the hematopoiesis process.
The document discusses the significance of blood cell production, known as hematopoiesis. It notes that hematopoiesis is important to study as it provides knowledge about stem cell biology and diseases. It also explains that blood cell production must occur continuously to replace old blood cells. The reflection then summarizes what was learned from watching an educational video about hematopoiesis. It describes the process starting from hematopoietic stem cells differentiating into various blood cell types, and how different cytokines regulate blood cell production levels. A concept map further illustrates the hematopoiesis process.
As a Medical Technology student, write down your ideas on the significance of
blood cell production. In my own perspective as a Medical Technology student the significance of blood cell production because it gives us the fundamental knowledge to study stem cell biology, and their contribution to disease and tissue repair. Moreover, it is significant because as we all know that blood cells has their certain lifespan and in order to have a replacement for the lost blood cells, blood cell production must occur continuously. Studying blood cell production can help us Medical Technology students understand better the processes behind blood disorders and cancers. Furthermore, blood cell production is significant as it is a lifelong process of continuous formation and turnover of blood cells to meet everyday demands as well as respond to increased demand, for example, injury or infection.
Activity 2
For better understanding
about the topic………
Watch this video and make a reflection
Hematopoiesis - Formation of Blood Cells, https://www.youtube.com/watch?v=0de
Animation Cbmh7PHs REFLECTION:
Primarily, I only have limited ideas on the concept of blood cell production scientifically known as the process of Hematopoiesis. The video presentation helped me a lot since it provided an avenue for me to learn the fundamental knowledge about blood cell production. As I’ve watched the video, I’ve grasped the idea that Hematopoiesis is a process where blood cells are continuously being replaced. In other words, it is a continued regulated process of blood cell production that includes blood cell renewal, proliferation, differentiation, and maturation. This process occurs in the red bone marrow of our body. The process of Hematopoeisis begins with the Hematopoietic Stem Cells (HSCs) or the Hemocytoblasts. All formed elements of blood are derived from this progenitor cells. HSCs are multipotent where they can differentiate to all types of blood cells and also they have the ability to multiply constantly to maintain their number in the bone marrow. The process of Hematopoiesis is regulated by several networks of signalling molecules called the Cytokines where they control the proliferation, differentiation, survival, and death of various progenitor cells. Consequently, the cytokines contribute significantly of hemostatic balance in both physiologic and pathologic conditions. In layman’s term these signalling molecules or the cytokines maintain the steady state levels of blood in the body in normal condition. In the production of RBC’s, differentiation starts when the Hematopoietic Stem Cells develop surface receptors for specific stimulating factor and in the case of RBC’s, Erythropoietin (EPO) is its stimulating factor. EPO is produce in the liver when we are still fetus and in the kidneys when we become adult. During the differentiation phase, the HSCs loss its potency and become committed to become a mature erythrocyte. In addition, in this phase also, there are events that occur in the HSCs where it decreases in size, increase in number, start making haemoglobin, and lose their nucleus. Furthermore, I’ve learned that whenever our RBC count in our body drops, our kidneys are triggered to produce EPO that increases our RBC by the end of 3-5 days. On the other hand, the production of Granulocytes and Macrophages is controlled by certain Colony-Stimulating Factors (CSF) which is the Granulocyte/Macrophage CSF, Granulocyte CSF, Macrophage CSF, and the Multipotential CSF. When there is an infection in our body, mature lymphocytes/macrophages produces CSF which stimulates the production of a certain type of WBC that would defend our body against the infection. The increase of Colony- Stimulating Factors in our body may indicate infection like bacterial endotoxins. Correspondingly in Platelet Production or Thrombopoiesis, the stimulating factor involve is the Thrombopoietin (TPO) which is a hormone secreted by our kidneys and liver. Platelet production starts when the HSC develop a surface receptors for Thrombopoietin where the HSC differentiates into a Megakaryocyte which will then become platelets. Platelets are small since they are just broken fragments of megakaryocyte’s cytoplasm. Further, platelet production is regulated by negative feedback mechanism in such way that when there is low platelet in the blood, production is promoted. Meanwhile, when there is high platelet in the blood, production is inhibited.
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