Mechanisms of Nursing

Name of Drug Indication Contraindication Adverse Effects

Action Responsibilities
Generic name: Used as perioperative Patients with Inhibits bacterial cell CV: hypotension,  Determine
Cefoxitin prophylaxis hypersensitivity drug wall synthesis by thrombophlebitis. previous
Brand name: or other binding up to 1 or hypersensitivity
Mefoxin cephalosporins; Use more of the penicillin- GI: to
Therapeutic Class: cautiously in patients binding proteins pseudomembranous cephalosporins,
Antibiotic with hypersensitivity (PBPs) which in turn colitis, nausea, penicillin, and
Pharmacologic to penicillin or has inhibit the final vomiting, diarrhea. other drug
Class: history of colitis, transpeptidation step allergies before
Second-generation renal insufficiency, or of peptidoglycan GU: acute renal therapy is
cephalosporin seizures. synthesis in bacterial failure. initiated.
Dosage: cell walls, thus  Lab tests:
Adults: inhibiting cell wall Hematologic: Perform culture
2g in 50-mL duplex biosynthesis and transient neutropenia, and sensitivity
containers; used as arresting cell wall eosinophilia, testing prior to
surgical prophylaxis assembly resulting in hemolytic anemia, and
given 2g IV 30-60 bacterial cell death. anemia, periodically
minutes prior to thrombocytopenia, during therapy.
surgery, then 2g IV Therapeutic effect: leukopenia, bone Periodic renal
every 6 hours for not Used for surgical marrow suppression. function tests.
more than 24 hours prophylaxis, reducing  Inspect
Route: or eliminating Respiratory: dyspnea injection sites
Intravenous infusion infection. with I.V. injection. regularly.
Pregnancy Skin: maculopapular Report
Classification: Pharmacokinetics: and erythematous evidence of
Category B rash, toxic epidermal inflammation
Absorption: Not necrolysis, urticaria, and patient's
absorbed from the GI pruritus, exfoliative complaint of
tract. dermatitis, pain, pain.
induration, sterile  Monitor I&O
Distribution: Widely abscesses, tissue rates and
distributed into body sloughing at injection pattern:
tissues and fluids site. Nephrotoxicity
(including bile, occurs most
synovial, and pleural); Other: frequently in
poorly penetrates CSF hypersensitivity patients >50 y,
even with inflamed reactions (serum in patients with
meninges. Crosses the sickness, impaired renal
 placenta and enters anaphylaxis), elevated function, the
breast milk. Plasma temperature. debilitated, and
protein binding: in patients
Approximately 70% receiving high
doses or other
nephrotoxic
Metabolism: About drugs.
2% of a cefoxitin dose  Monitor all
is metabolized. patients for
superinfection or
Excretion: Excreted diarrhea and treat
primarily in urine by appropriately,
renal tubular secretion especially if large
and glomerular doses are given,
filtration; small therapy is
amounts of drug prolonged, or
appear in breast milk. patient is at high
Elimination half-life risk.
is about 0.7 to 1.1
hours in patients with
normal renal function;
half-life is prolonged
in patients with severe
renal dysfunction to
6.3 to 21.5 hours.
Cefoxitin can be
removed by
hemodialysis but not
by peritoneal dialysis.

Half-life: 45-60
minutes

Reference:

CEFOXITIN SODIUM. (n.d.). Rob Holland. Retrieved November 9, 2020, from

http://robholland.com/Nursing/Drug_Guide/data/monographframes/C044.html
Cefoxitin sodium. (n.d.). GLOWM. Retrieved November 9, 2020, from https://www.glowm.com/resources/glowm/cd/pages/drugs/c031.html

Department of Health. (2017). National Antibiotic Guidelines 2017. http://thepafp.org/website/wp-content/uploads/2017/05/2017-National-

Antibiotic-Guidelines-DOH.pdf

Lippincott Williams & Wilkins. (2019). Nursing 2020 Drug Handbook (Vol. 1). Philadelphia, Pennsylvania: Wolters Kluwer.

MIMS. (n.d.). Cefoxitin. Retrieved November 9, 2020, from https://www.mims.com/philippines/drug/info/cefoxitin?mtype=generic

Philippine College of Surgeons Committee on Surgical Infections. (2002). Evidence-Based Clinical Practice Guidelines on the Diagnosis and
Treatment of Acute Appendicitis. https://pcs.org.ph/assets/images/EBCPG-acute_appendicitis.pdf

World Health Organization. (2007). Essential Drug List. https://www.who.int/selection_medicines/country_lists/phl_edl_2007.pdf?ua=1