Pathophysiology - Appendicitis

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PATHOPHYSIOLOGY

APPENDICITIS

Predisposing Factors
Precipitating Factors
-Age (9 years old)
- Sedentary Lifestyle
- Low Fiber Diet
- Bowel movement: 3-4 times a
week
Obstruction of the appendiceal lumen
(inside the appendix)

Build-up of mucus in the


appendix

Afferent visceral Increase appendiceal


nerve fibers lumen pressure

Abdominal Pain

Decrease blood flow to the


appendix

Decrease oxygen delivery

Ulceration (lesion) on the


appendix mucosal lining
Promotes of microbe invasion

Inflammation and swelling of the


appendix

Signs and Symptoms:

 Acute RLQ pain of the


abdomen
 Fever
 Vomiting
 Loss of appetite

Inflammation and infection Appendectomy


spread
Pain medications
through the wall of the appendix
causing death of tissue.
The appendix ruptures due
to increase pressure
(Perforation)

Perforation (formation of a hole


in an organ), fecal materials exits
to peritoneal cavity causing
formation of abscesses
(periappendiceal abscess).
Infection can spread throughout
the abdomen (peritoneal cavity)
Bacterial invasion of Peritoneal
Cavity causing inflammation of
the membrane that lines the
abdomen peritoneum (Peritonitis)
S/S: swelling of the abdomen,
severe pain, and weight loss

Sepsis (the condition or syndrome


caused by the presence of
microorganisms or their toxins in
the tissue or the bloodstream)
Septicemia

IF TREATED
IF NOT TREATED`

Septic Shock
S/S:
 decrease Blood
pressure
 decrease blood
volume
Strong antibiotic
Medication

Fluid Volume Replacement


therapy

COMA
RECOVERY

DEATH

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