Addison and Cushing

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Addisonian crisis

Can result to death

Characterize by cyanosis, signs of circulatory shock: pallor, apprehension, rapid and weak pulse, rapid
respirations, and low blood pressure. Others: headache, nausea, abdominal pain, diarrhea, confusion,
and restlessness

Management

Assess for signs and symptoms of shock

Avoid physical and psychological stressors (cold exposure, over exertion, infection, and emotional
distress)

Provide treatment (IV fluids, glucose and electrolytes esp. sodium. Replace steroid hormones and
administer vasopresors

Monitor for adverse effects of adrenocortical activity (f&E lab values, daily weight, blood glucose, report
blood glucose elevation)

CUSHING’S Syndrome

- Excessive adrenocortical activity

Causes:

Use of corticosteroids

Primary hyperplasia of adrenal glands

Ectopic production of ACTH

Adrenal cortex

- Releases steroid hormones (aldosterone (mineralocorticoid), Cortisol (glucocorticoid), Androgen


(sex hormone))

Aldosterone

- Regulates blood pressure through renin-angiotensin-aldosterone system


- Retaining sodium
- Secretes potassium

Cortisol

- Stress hormone
- Helps body to deal with stress
- Increases blood glucose
- Breaks don fats, protein, carbs
- Regulates electrolytes

Negative feedback

Hypothalamus = CRH -> Pituiary = ACTH -> Adrenal cortex = Cortisol

Cushing – Cortisol increased

Nursing intervention

Addisons - decreased Cortisol and Aldosterone

FORMATIVE ACTIVITY

19. Addison's disease decreases the production of all adrenal hormones, compromising the
body's normal stress response and increasing the risk of infection. 

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