*SLRTV15*

SLR-TV – 15
Seat
No. Set P
B.Pharm. (Semester – III) (New CBCS) Examination, 2018
pharmaceutical organic chemistry – II

Day and Date : Saturday, 8-12-2018 Max. Marks : 75

Time : 10.30 a.m. to 1.30 p.m.

I. Choose the most appropriate answers from the following answers : (20×1=20)
1) Identify a compound which is non-aromatic, from the following
a) Cycloheptatrienyl cation b) Cyclobutadiene
c) Cycloheptatriene d) Cyclohexatriene
2) An a mine with a ‘pKa’ value of ________ is more basic.
a) 11 b) 7.8
c) 4 d) 0.78
3) Identify the following reaction :
(RCO)3 Glycerol (TAG) + R’OH (Excess)

a) Trans-acidification b) Trans-esterification
c) Hydrolysis d) None
4) The correct starting material for preparing esters by Fischers method is
a) RCONH2 b) (RCO)2O
c) RCOOH d) RCOCl
5) Anthracene on nitration yields ________ derivative.
a) 1-nitro b) 2-nitro
c) 9-nitro d) 1, 2-dinitro
6) Reichert-Meissel number indicates volatile but water ______ Small Chain
Fatty Acids.
a) Soluble b) Insoluble
c) Miscible d) None
7) Identify the functional group which increases acidity when present on a
phenol
a) –CH3 b) –CH3O
c) –OH d) –NO2

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SLR-TV – 15 -2- *SLRTV15*
8) Least basic of the following compounds is
a) R2NH b) R3N
c) ArNH2 d) R – NH2
9) Correct name of the compound with CH3-(OH)-CH-CH-(C2H5)-side chain
at 4-position of C6H4OH is
a) 4-(2-OH-1-ethyl) propyl Phenol
b) 4-(1-ethyl-2-OH) propyl Phenol
c) 2-OH-3-ethyl-3- hydroxyl phenyl propane
d) None
10) Product obtained on heating phthalic acid in presence of ammonia is
a) Maleimide b) Phthalimide
c) Phthalic anhydride d) None
11) Which acid with ______ pKa value is the most acidic.
a) 10 b) 2
c) 8 d) 4
12) Most common fatty acid among the natural FAs is
a) Caproic b) Myristic
c) Oleic d) Linoleic
13) The product of reaction between Cycloproane and Br2 is
a) Cyclopropane
b) 1-Bromo Cyclopropane
c) 1, 2- dibromo Cyclopropane
d) 1, 2, 3- tribromo Cyclopropane
14) Identify the correct structure for Linoleic acid.
a) 18 : 0 b) 18 : 1
c) 18 : 2 d) 18 : 3
15) 4-sulphonate derivative of phenols is formed at
a) 100°C b) 0°C
c) 25°C d) –15°C
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*SLRTV15* -3- SLR-TV – 15
16) Oxidation of Phenanthrene with ozone yields
a) Diphenyl dicarboxyl ‘
b) Diphenyl dicarboxaldehyde
c) 9,10-diphenanthrone
d) None
17) Saponification value of oil indicates _______ in an oil sample.
a) Free fatty acid
b) Unsaturation
c) Mol. wt
d) Average mol. weight
18) According to Bayer, angular strain in cyclobutane is
a) – 5°16’ b) 24° 44’
c) 0° 44’ d) 9° 44’
19) Chloro benzene on nitration yields ______ derivative.
a) o-nitro b) p-nitro
c) m-nitro d) o, p and m-nitro
20) Which of the reaction is not possible when replacement reaction with
diazonium salt is carried out
a) Hoffmann
b) Gomberg
c) Scheimann
d) Sand-Meyer

II. Answer any two questions of the following : (2×10=20)

1) What is aromaticity ? How it could be explained using Huckel’s rule. Describe
EAS reactions in benzene. (5+5)
2) a) What is acid value ? What is the importance of its determination ?
b) List and explain chemical reactions of aromatic acids. (5+5)
3) Discuss :
a) Chemical reactions of Phenanthrene.
b) Two methods of preparation of cyclobutane and cyclopropane. (5+5)
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SLR-TV – 15 -4- *SLRTV15*

III. Answer any seven questions of the following : (7×5=35)

1) Write five chemical reactions undergone by aromatic amines.
2) Explain how Naphthalene is synthesized in the laboratory.
3) Explain how basicity of aromatic amines changes with substituents on the
ring and on the amine ‘N’.
4) Explain the chemical basis for “rancidity of oil” and methods to prevent it.
5) Write the structure and uses of : a) Diphenyl methane b) Anthracene.
6) Write two methods of preparation for cyclopropane and cyclobutane.
7) List and describe special reactions of Phenols.
8) Describe the principle, method and significance of Saponification value
determination of an oil sample.
9) Demonstrate with two examples how diazotization can be used for attaching
a second group at a specific point on a benzene ring.
___________

Set P
*SLRTV16* SLR-TV – 16
Seat Set P
No.

B.Pharm. (Sem. – III) (New CBCS) Examination, 2018

PHYSICAL PHARMACEUTICS – I

Day and Date : Tuesday, 11-12-2018 Total Marks : 75

Time : 10.30 a.m. to 1.30 p.m.

I. Choose the correct alternative : (20×1=20)

1) An Azetropic mixture of two liquids boils at lower temperature than either
of them when
A) It is saturated
B) It shows positive deviation from Raoult’s law
C) It is Metastable
D) It shows negative deviation from Raoult’s law
2) Colligative properties are the properties of the solution that depends upon
A) Nature of molecules B) Quality
C) Physical properties D) Number of Molecules
3) The solubility of gases increases in liquid with decreasing
A) Mass B) Volume
C) Temperature D) Pressure
4) If a solution has to be a buffer, its pH should be
A) As its pKa value B) At is Ka Value
C) At 7 D) At 14
5) The vander Waal radius of hydrogen atom in water molecule is
A) 1.2 A° B) 1.4 A°
C) 1.6 A° D) 1.8 A°
6) Normal pH of blood is
A) 7.0 B) 7.2
C) 7.1 D) 7.4
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SLR-TV – 16 -2- *SLRTV16*

7) The Heat of vaporization of water molecules at atmospheric temperature

is
A) 1260 J/g B) 2260 k.cal
C) 2260 J/g D) 1260 k.cal

8) Ions which are produced from ligands are

a) Cations b) Complex ion
c) Anion d) All of them

9) Terms and conditions of Nernst’s law

A) Constant Temperature B) Dilute solution
C) Non-miscible solvents D) All

10) In Nematic crystals, molecules are mobile in how many dimensions.

A) One B) Two
C) Three D) Zero

11) Buffer Capacity is the maximum at

A) pKa = pH B) pKa < pH
C) pka = Concentration D) pka > pH

12) At Constant temperature the solubility of gas in a liquid is proportional to

the pressure of the gas above it is called as
A) Raoult’s law B) Henry’s law
C) Graham’s law D) None of above

13) The Amorphous form of drug dissolves ____________ than the crystalline
form.
A) Faster B) Slower
C) Equal to one D) Does not dissolve
14) Spreading agents usually have an HLB value in the ranges
A) 0-3 B) 9-12
C) 7-9 D) 8-16
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15) The pKw at 25°C is

A) 7.0 B) 10
C) 5.0 D) 14
16) When a suitable pH of solution is added to an acidic drug, the solubility is
promoted due to
A) Enhanced ionization B) Formation of drug solvates
C) Formation of salt D) Improved stability
17) The Partition coefficient considers the solute concentration as one of the
following (molecular) species
A) Dimer B) Dissociated Ion
C) Hydrate and Solvate D) Monomer
18) Which of the following is not a multiple ligand ?
A) EDTA B) Ammonia
C) Deferoxamine D) Dimethylglycoxime
19) Protein binding _______________ distribution of drugs.
A) Increases B) Prevents
C) Decreases D) None of these
20) The rapid increase in solubility of a surfactant solution above a definite
temperature is known as
A) Cloud point B) Krafft point
C) CMC D) Triple point

II. Solve any two : (2×10=20)

a) Explain in detail methods used for liquification of gases.
b) What is adsorption isotherm ? Discuss in detail Freundlich and Langmuir
adsorption Isotherm.
c) Define partition coefficient. Explain its derivation and principle behind
Association and dissociation of molecules.

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SLR-TV – 16 -4- *SLRTV16*

III. Solve any seven : (7×5=35)

1) Define Critical Solution Temperature. Write note on UCT and LCT.

2) What is Kinetic Molecular Theory ? Give its assumptions for Kinetic Molecular
Theory.

3) Explain factors affecting on solubility of gases in liquids.

4) Explain buffer equations for weak acid and its salt.

5) Discuss methods used to determination of pH.

6) Discuss methods for determination of Complexation.

7) Explain the mechanism of Solute-Solvent Interaction.

8) Write note on Eutectic Mixtures and Polymorphism.

9) Discuss in detail Spreading Coefficient.

_________________

Set P
*SLRTV17* SLR-TV – 17
Seat
No.
Set P

B.Pharmacy (Semester – III) (New CBCS) Examination, 2018

pharmaceutical Microbiology
Day and Date : Thursday, 13-12-2018 Max. Marks : 75
Time : 10.30 a.m. to 1.30 p.m.

1. Multiple Choice Questions : (20×1=20)

1) The purpose of staining is to demonstrate
a) Cell size b) Cell shape
c) Arrangement of bacterial cell d) All of above
2) The process of autoclaving is
a) Only vegetative cell gets killed
b) Spores and vegetative cell gets killed
c) Spores get killed only
d) Nucleus of the cell gets killed
3) Efficiency of HEPA filter is
a) 99.97 b) 88.87 c) 90.97 d) 98.97
4) The media in which nutritional environment is provided in such a way that
growth of certain bacteria is enhanced than other is called
a) sugar media b) transport media
c) enriched media d) enrichment media
5) Radiation used for cold sterilization are
a) X-ray b) Gamma rays c) Cosmic rays d) All of above
6) The phase of maximum multiplication result in increased population of
bacteria with reduced generation time is
a) log phase b) lag phase
c) decline phase d) stationary phase
7) Testing which confirms that products are free from the presence of viable
microorganisms is known as
a) sterility testing b) pyrogen testing
c) minimum inhibitory coefficient d) none of above
8) A fully assembled infectious virus is called as
a) micron b) prion c) virion d) none of above
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SLR-TV – 17 -2- *SLRTV17*
9) The mycellum is complex of several filaments called
a) Lumen b) Hyphae c) Septum d) Plasmalemma
10) DNA present in bacteria is
a) Single, circular b) Single, linear
c) Single, crossed d) Double, circular
11) Which of the following methods are used for obtaining pure culture of
microorganisms ?
a) Streak plate method b) Pour plate method
c) Spread plate method d) All of above
12) The stain which differentiates two groups of bacteria in a mixture is known as
a) Negative stain b) Simple stain
c) Differential stain d) Indirect stain
13) Which of the following are chemical indicators of sterilization ?
a) Browne’s tube b) Witness tube
c) Royce Sachet d) All of above
14) Test based on the rise of body temperature of rabbit is
a) Sterility testing b) Pyrogen testing
c) Minimum inhibitory coefficient d) None of above
15) Best autoclaving is achieved at
a) 121°C for 15 min. b) 120°C for 1 hr.
c) 110°C for 2 hrs. d) 100°C for 3 hrs.
16) Microorganisms which grow in absence of oxygen are called
a) Aerobic b) Microscopic c) Anaerobic d) None of above
17) Dop test is used for validation of
a) Membrane filter b) HEPA filter
c) Aseptic room d) Autoclave
18) Citrate utilization test is usually performed on
a) Chocolate agar b) Simmon’s citrate agar
c) Nutrient agar d) MacConkey agar
19) On the outer surface of the viral envelope, glycoprotein subunits exposed
in the form of projecting spikes are known as
a) Capsid b) Capsule c) Peplomers d) All of above
20) When finite cell line undergoes transformation and acquires the ability to
divide indefinitely, it becomes
a) Continues cell line b) Discontinuous cell line
c) Infinite cell line d) Both b and c
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2. Answer any 2 of the following : (2×10=20)
1) What is sterilization ? Classify and explain.
2) Write a note on designing of aseptic area.
3) Describe bacterial anatomy.

3. Answer any 7 of the following : (7×5=35)

1) Classify virus.
2) Write about assessment of microbial contamination and spoilage.
3) Describe about bacterial growth curve.
4) Explain about different culture media.
5) Describe about cultivation of viruses in chick embryo.
6) Describe cup plate method.
7) Write characteristic of ideal disinfectant.
8) Explain working and principle of autoclave.
9) What is IMViC test ?
_______________

Set P
*SLRTV18* SLR-TV – 18
Seat
No. Set P
B.Pharm. (Semester – III) (New) (CBCS) Examination, 2018
Pharmaceutical Engineering
Day and Date : Monday, 17-12-2018 Max. Marks : 75
Time : 10.30 a.m. to 1.30 p.m.

1. MCQ’s : 20
1) If particle of fluid flow same path the flow said to be
a) Laminar flow b) Turbulant flow
c) Fluid flow d) Both a) and b)

2) Fluid energy mill is also known as

a) Micronizer b) Jet Mill c) Pulveriser d) All of the above

3) Bernoullis equation can be derived from conservation of

a) Energy b) Mass
c) Angular momentum d) None of the above

4) End runner mill works on principle of

a) Crushing and Friction b) Cutting and Attrition
c) Crushing and Shearing d) Grinding

5) Manometer is used to measure

a) Fluid flow b) Fluid pressure
c) Temperature d) Pressure

6) The mill does not have any moving part in the grinding area
a) Disintegrator Mill b) Hammer Mill
c) Collid Mill d) Fluid energy Mill

7) Which mill works on principle impact and attrition ?

a) Hammer Mill b) Ball Mill
c) Roller Mill d) All the above

P.T.O.
SLR-TV – 18 -2- *SLRTV18*

8) Heat transfer take place as per

a) Zeroth law of thermodynamics
b) First law of thermodynamics
c) Second law of thermodynamics
d) Kirchhoff’s Law
9) Elutriation is process of
a) Size reduction using mechanical force
b) Size separation using stationary fluid
c) Size reduction using electrical force
d) Size separation by using moving fluid
10) Evaporation occur only
a) After boiling b) After extreme cooling
c) At surface of fluid d) None of the above
11) Heat transfer in liquid and gases takes place by
a) Conduction b) Convection
c) Radiation d) None of the above
12) Fourier law of heat conduction is valid for
a) One dimensional cases only b) Two dimensional cases only
c) Three dimensional cases only d) None of the above
13) Most commonly used size separation instrument in laboratory
a) Cyclone separator b) Sedimentation tank
c) Sieve shekar d) All the above
14) Differential distillation is
a) Simple distillation b) Vaccum distillation
c) Molecular distillation d) None of the above
15) The condensate which returns to the liquid mixture is known as
a) Distillate b) Feed c) Distilland d) Reflux
16) How the liquid does gate separate in freeze dryer ?
a) Boiling b) Distillation c) Freezing d) None of the above

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17) Moisture inside the substance is known as

a) Bound moisture b) Unbound miosture
c) Equilibrium moisture d) Free moisture
18) This is irreversible type of mixing
a) Positive mixing b) Negative mixing
c) Neutral mixing d) None of the above
19) Which one of the following is continuous type of centrifuge ?
a) Perforated centrifuge b) Super centrifuge
c) Non-perforated centrifuge d) None of the above
20) Corrision of metal involves
a) Physical reaction b) Chemical reaction
c) Both a) and b) d) None of the above

2. Solve any two : (2×10=20)

1) Define distillation, write application of distillation and explain construction,
working laboratory scale vacuum distillation unit.
2) Explain in detail Ball Mill with its merits and demerits.
3) Write construction, working principle, advantage, disadvantage of Fluid
energy mill .

3. Solve any seven : (7×5=35)

1) Write in detail factor affecting size reduction.
2) Write pharmaceutical application and mechanism of size reduction.
3) Write a note on spiral plate exchanger with its advantage and disadvantages.
4) Explain in detail Multiple effect evaporator.
5) Explain theory of corrosion.
6) Write pharmaceutical application of filtration and theory of filtration.
7) Write a note on Lyophylizer .
8) Define corrosion and explain types of corrosion.
9) Write factor affecting on mixing and explain mechanism of solid mixing.

_____________________

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