OAU Antibiotic Class Definitions

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Antibiotic Resistance Patient Safety Atlas

Outpatient Antibiotic Prescription Data

Antibiotic Class Definitions


The Outpatient Antibiotic Prescription data section of the Patient Safety Atlas provides data on oral antibiotic
prescriptions dispensed to outpatients in U.S. community pharmacies.
Antibiotics are usually classified or grouped by their chemical structure. Some antibiotic classes work by killing
bacteria and others work by preventing the ability of bacteria to multiply.
All of these antibiotics are currently included in the AR Patient Safety Atlas national data, but not all are available
in the map format of state data.
Class Examples How They Work
Penicillins penicillin, amoxicillin Penicillins kill bacteria by preventing formation of the
bacterial cell wall.
Macrolides azithromycin, Macrolides prevent bacteria from multiplying by
erythromycin keeping bacteria from making proteins.
Cephalosporins cephalexin, cefdinir Cephalosporins kill bacteria by preventing formation
of the bacterial cell wall.
Fluoroquinolones ciprofloxacin, levofloxacin Fluoroquinolones kill bacteria by keeping bacteria
from making DNA.
Beta-lactams with amoxicillin/clavulanate, Beta-lactams with increased activity are combinations
increased activity ceftazidime/avibactam that consist of two different drugs: a penicillin or
cephalosporin and a beta-lactamase inhibitor. The
penicillin or cephalosporin kills bacteria by preventing
formation of the bacterial cell wall. The beta-lactamase
inhibitor has little antibiotic activity on its own. Its job
is to protect the penicillin or cephalosporin from being
destroyed by an enzyme some bacteria produce. This
protection increases the activity of the penicillin or
cephalosporin.
Tetracyclines tetracycline, doxycycline Tetracyclines prevent bacteria from multiplying by
keeping bacteria from making proteins.
Trimethoprim- trimethoprim- Trimethoprim and sulfamethoxazole work together to
sulfamethoxazole sulfamethoxazole inhibit the ability of bacteria to make folic acid, which
is necessary to make DNA and proteins. This prevents
bacteria from multiplying.
Urinary anti- nitrofurantoin Depends of the specific drug. For nitrofurantoin,
infectives depending on the concentration, it either kills bacteria
or prevents them from multiplying by keeping bacteria
from making DNA, proteins, and the bacterial cell wall.
Lincosamides clindamycin Lincosamides prevent bacteria from multiplying by
keeping bacteria from making proteins.

National Center for Emerging and Zoonotic Infectious Diseases


Division of Healthcare Quality and Promotion

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