Epidemiology - Upper Epigastric Pain
Epidemiology - Upper Epigastric Pain
Epidemiology - Upper Epigastric Pain
results from obstruction of the cystic duct, usually by a gallstone, followed by distension and subsequent
chemical or bacterial inflammation of the gallbladder
(SLIDE 2)
Gallstones are quite prevalent in most Western countries. Gallstone formation increases after age 50. In
the United States, the third National Health and Nutrition Examination Survey (NHANES III) has revealed
an overall prevalence of gallstones of 7.9% in men and 16.6% in women. The prevalence was high in
Mexican Americans (8.9% in men, 26.7% in women), intermediate for non-Hispanic whites (8.6% in men,
16.6% in women), and low for African Americans (5.3% in men, 13.9% in women).
(SLIDE 3)
Gallstones are formed because of abnormal bile composition. They are divided into two major types:
A. Cholesterol stones
account for >90% of all gallstones in Western industrialized countries
usually contain >50% cholesterol monohydrate plus an admixture of calcium salts, bile
pigments, proteins and fatty acids
B. Pigment stones
composed primarily of calcium bilirubinate
they contain <20% cholesterol and are classified into “black” and “brown” types, the
latter forming secondary to chronic biliary infection