JP 2018-90631 A 2018.6.

14

(57) [Summary]

PROBLEM TO BE SOLVED: To cause troubles on the appearance of skin such as wrinkles, fine wrinkles, age spots and slack due to aging and aging.

Prevent or improve and maintain or maintain barrier function and hyaluronic acid production in the skin

It is an object of the present invention to provide an external composition for skin for anti-aging for enhancing.

SOLUTION: L-ascorbic acid, a derivative thereof, and an active ingredient based on an aqueous medium.

And one or more selected from these salts for anti-aging skin external use

The above problem is solved by providing an adult product.

[Selection diagram] None

 (2) JP 2018-90631 A 2018.6.14

[Claims]

[Claim 1]

Induction of L-ascorbic acid and L-ascorbic acid as active ingredients based on an aqueous medium

Anti-aging skin containing one or more selected from conductors and salts thereof

Topical composition.

2.

The derivative of L-ascorbic acid is a glycosyl derivative of L-ascorbic acid, which induces acylation.

The composition for external use on the skin for anti-aging according to claim 1, which is a conductor or a phosphorylated derivative.

3.

The glycosyl derivative of L-ascorbic acid is 2-O-α-D-glucosyl-L-ascor Ten

It is a biacid, the salt of which is a sodium salt, 2-O-α-D-glucosyl-L-as.

The anti-aging skin according to claim 2, which contains corbic acid and / or a sodium salt thereof.

Topical composition.

4.

The invention according to any one of claims 1 to 3, which prevents or improves wrinkles, fine wrinkles, age spots, or slack.

Topical skin composition for anti-aging.

5.

Claims 1 to 4 that maintain or enhance the barrier function and hyaluronic acid production in the skin.

The anti-aging skin external composition according to any one of.

6. 20

A plant extract or compound that has a skin turnover improving effect and / or a glycation reaction suppressing effect.

The anti-e according to any one of claims 1 to 5, further comprising one type or two or more types selected from the products.

Topical skin composition for Ising.

7.

A plant extract or compound that has a skin turnover improving effect and / or a glycation reaction suppressing effect.

The thing is the extract of Cupressaceae plant, the extract of Ginkgoaceae plant, the extract of Rutaceae plant,

Lamiaceae plant extract, Lizard tails plant extract, Eucommiaceae plant extract, and d

The external composition for skin for anti-aging according to any one of claims 1 to 6, which is quoll.

8.

Cupressaceae is Asunaro, Ginkgoaceae is Ginkgo, and Rutaceae is Oubaku. 30

, Orange, grapefruit, citron, and lemon, Labiatae plants are mint, peppermin

To, perilla, and rosemary, plants of the family Houttuynia cordata, and plants of the family Eucommia ulmoides

The composition for external skin for anti-aging according to claim 7, which is Chu.

9.

2-O-α-D-glucosyl-L-ascorbic acid per composition is L-ascorbic

1 to 10% by mass in terms of acid anhydride, skin turnover improving effect and / or glycation reaction inhibition

A total of one or more selected from harmful plant extracts, compounds, and equol

The anti-aging skin external use according to claim 3 to 8, which comprises 0.01 to 1% by mass.

Composition.

10. 40

Basic makeup containing the anti-aging skin external composition according to any one of claims 1 to 9.

Goods.

11.

The basic cosmetic according to claim 10, which is a lotion, a cleanser, a beauty essence, a milky lotion, or a cream.

12.

One selected from L-ascorbic acid, derivatives of L-ascorbic acid, and salts thereof

Alternatively, any of claims 1 to 11, which comprises a step of mixing two or more kinds with an aqueous medium as a base.

The method for producing an anti-aging external composition for skin or basic cosmetics according to the above.

13.

The derivative of L-ascorbic acid is 2-O-α-D-glucosyl-L-ascorbic acid. 50

 (3) JP 2018-90631 A 2018.6.14

The salt is a sodium salt, 2-O-α-D-glucosyl-L-ascorbic acid.

1 and / or a step of mixing the sodium salt thereof with an aqueous medium as a base.

2. The method for producing an anti-aging external composition for skin or basic cosmetics according to 2.

14.

2-O-α-D-glucosyl-L-ascorbic acid and / or its sodium salt crystallizes

The production of the anti-aging skin external composition or basic cosmetics according to claim 13 in the form of

Method.

15.

The sodium salt of 2-O-α-D-glucosyl-L-ascorbic acid in crystalline form

, In powder X-ray diffraction, diffraction angles (2θ) 6.8 °, 8.2 °, 14.3 °, 17.8 ° Ten

2-O-α-D-glucosyl-L-ascorbic acid showing a diffraction peak at 18.4 °

Hydrous crystals of sodium salt or diffraction angles (2θ) 8.0 °, 9.0 °, 16.4

2-O-α-D-glucosyl-L- showing diffraction peaks at °, 17.9 °, and 20.8 °

The anti-aging skin according to claim 14, which is an anhydrous crystal of sodium ascorbate.

A method for producing an external composition or basic cosmetics.

16.

2-O-α-D-glucosyl-L-ascorbic acid and its sodium salt as a base

2-O-α-D-glucosyl-L-ascorbic acid in the step of mixing with the aqueous medium of

Including the step of mixing the sodium salt of the above with an aqueous medium as a base, using alkali 2-

Claim 12 performed without neutralizing O-α-D-glucosyl-L-ascorbic acid 20

The method for producing an anti-aging external composition for skin or basic cosmetics according to any one of 15 to 15.

..

17.

2-O-α-D-glucosyl-L-ascorbic acid and its sodium salt as a base

2-O-α-D-glucosyl-L used in the above step of mixing with the aqueous medium of

-The pH of ascorbic acid and its sodium salt after mixing with an aqueous medium was predetermined.

The anti-dose according to claim 16, which is in the form of a composition blended in a ratio within a predetermined range.

A method for producing an external composition for Ising or basic cosmetics.

18.

Contains 2-O-α-D-glucosyl-L-ascorbic acid and crystals of its sodium salt 30

Composition.

19.

Combination ratio of 2-O-α-D-glucosyl-L-ascorbic acid and its sodium salt crystals

However, the composition according to claim 18, which is in the range of 60:40 to 45:55 in terms of mass ratio in terms of anhydride.

Stuff.

20.

Crystals of sodium salt of 2-O-α-D-glucosyl-L-ascorbic acid, powder X-ray

In diffraction, diffraction angles (2θ) 6.8 °, 8.2 °, 14.3 °, 17.8 °, and 18

.. 2-O-α-D-glucosyl-L-sodium ascorbate showing diffraction peak at 4 °

It is a hydrous crystal of salt, or the diffraction angle (2θ) is 8.0 °, 9.0 °, 16.4 °, 17. 40

2-O-α-D-glucosyl-L-ascorbi showing diffraction peaks at 9 ° and 20.8 °

The composition according to claim 16 or 19, which is an anhydrous crystal of a sodium acid salt.
Description: TECHNICAL FIELD [Detailed description of the invention]

【Technical field】

[0001]

The present invention relates to an anti-aging external composition for skin and a method for producing the same.

Topical anti-aging composition for preventing or improving wrinkles, fine wrinkles, age spots, or looseness.

It relates to basic cosmetics including these and their manufacturing methods.

[Background technology]

0002. 50
 (Four) JP 2018-90631 A 2018.6.14

The desire to be youthful forever is a universal desire common to all humankind, but age is important.

It is a long time for human beings to see changes such as wrinkles, fine wrinkles, age spots, and slack on human skin as they sleep.

I have experienced it for a long time, and as I get older, my skin ages, and my skin wrinkles and fine lines.

Appearance of changes in appearance such as wrinkles, blemishes, and slacks is, so to speak, a natural providence and is inevitable.

It was thought to be something.

0003

However, in recent years, research on the structure of human skin and its metabolic mechanism has progressed.

As we age, changes such as wrinkles, fine wrinkles, age spots, and slack appear on human skin.

The cause and mechanism are gradually becoming clear. That is, as is well known, the skin

It is composed of a thin outer epidermis (epithelial tissue) and a thick dermis (connective tissue) underneath. Ten

The epidermis, as the outermost layer of the body, protects the living body from the outside world and removes water and nutrients inside.

Prevents leakage to the world, while the dermis is predominantly fibroblasts, collagen fibers, elastic

Fiber (elastin), proteoglycan, etc. have a complex three-dimensionally spread structure

It is a composite tissue that plays a role in providing strength, extensibility and elasticity to the skin, but with aging.

When the amount of sebum and water in the skin decreases, the moisturizing power of the stratum corneum on the skin surface is lost.

It is said that fine wrinkles and dry skin are likely to occur due to dryness.

0004

In addition, the human epidermis is the "stratum corneum (stratum corneum)", "granular layer", "stratum spinosum", and "basal layer" from the outside.

It is composed of "layers", and epidermal cells (keratinocytes) born in the basal layer move outward in sequence.

It becomes the stratum corneum and eventually peels off. For more details, the kerachinosite table 20

It proliferates in the innermost basal layer of the skin, differentiates, is pushed up to the upper layer, and finally the first part of the epidermis.

It becomes the stratum corneum (stratum corneum) located on the outside, and becomes dirt and falls off. Of this kerachino site

A series of processes of proliferation, migration, differentiation, and shedding is called turnover, and keratinocytes are constant.

The homeostasis of the skin is maintained by being reborn in the cycle, but aging

As a result, the turnover speed of the skin slows down, resulting in wrinkles, looseness, and rough skin.

It has been The turnover rate of the skin varies depending on the part of the human body, but generally

It is said that the turnover of healthy teenage human skin is about 20 days, and that of 20s is about 28 days.

, About 40 days for people in their 30s, about 55 days for people in their 40s, about twice as long as for people in their 20s, and about 75 days for people in their 50s.

It is said that By the way, skin turnover is not desirable either early or late.

The normal turnover of the skin is said to be 28 days in the 20s. This is the turnover speed 30

The amount of melanin pigment produced by melanocytes that absorbs UV light in the skin at an early rate

This is because UV rays promote cosmetically unfavorable melanin deposition.

0005

In addition, as a recent finding, in vivo glycation reaction in the skin (hereinafter, simply referred to as "glycation reaction").

U. ) Is involved in the delay in skin turnover speed and is said to be associated with skin aging

There is. The saccharification reaction is also called the Maillard reaction (browning reaction), and glucose or fructose.

Reducing sugars such as sucrose bind non-enzymatically to the dermis (collagen) and stratum corneum (keratin), resulting in glycation.

It means the process leading up to the production of a substance called advanced glycation end products (AGEs). AGEs are deposited on the skin

tissue and R

It binds to receptors called AGEs (receptors for AGEs) and binds to the skin and other 40

Intramolecular collagen in the process of inducing inflammatory changes in tissues and producing AGEs

And forms disordered crosslinks between molecules, causing physical and physiological changes (denaturation) in collagen

It is known to cause skin aging such as stiffness, wrinkles, rough skin, dullness, or reduced elasticity.

ing. In addition, collagen in which disordered crosslinks are formed within and between molecules by saccharification reaction.

It loses its elasticity and is less likely to be broken down by proteases in the body.

As a result, it is said that the turnover speed of the skin may be delayed (non-patent literature).

1).

0006

As mentioned above, age-related delays in skin turnover speed can also cause wrinkles, looseness and rough skin.

Since it is said to be irritating, these skin symptoms begin to be anxious around 30 to 50 years old. 50
 (Five) JP 2018-90631 A 2018.6.14

For the skin of the so-called pre-aging generation, including the age group of, the turnover speed is 2

By some means, even if it is difficult to return to normal skin turnover speed in the 0s

If it is possible to recover from the delay in turnover speed that accompanies aging, wrinkles and slackening will occur.

Rough skin can be effectively improved. From this point of view, the proliferation and migration of keratinocytes,

Increase turnover speed by facilitating at least one process of differentiation and shedding

Increase or inhibit glycation reactions that may result in delayed turnover rates

It is thought that the turnover speed can also be increased by doing so. But still

, No practical solution is provided.

0007

In addition, with aging, fibroblasts and hyaluronic acid in the dermis decrease, and collagen Ten

When amputation or degeneration of elastin occurs, wrinkles are formed and the elasticity of the skin decreases and loosens.

It is said that rough skin occurs. In addition, melanocytes excreted from melanocytes into epidermal cells

The fact that the skin is not smoothly discharged from the epidermal cells causes pigmentation (stains) on the skin and dullness of the skin.

There is also a finding that it is the cause.

0008

Based on these research results and findings, wrinkles and fine lines on human skin are now present with age.

Reasonably prevent or improve the appearance of changes such as wa, spots, and slack from a scientific point of view.

A large number of external preparations for skin for anti-aging have been proposed (see, for example, Patent Documents 1 to 7).

As a result, humankind is approaching the realization of the desire to be youthful forever.

There is one. However, there are many possible anti-aging topical skin preparations currently proposed. 20

It pursues and realizes only a small part of the possibilities, and has an anti-aging effect.

Including different mechanisms played, ease of use, and ease of manufacturing

Therefore, it is still possible to provide new anti-aging skin external preparations from more angles.

The current situation is that it is desired.

[Prior Art Document]

[Patent Document]

0009

[Patent Document 1] Republished Patent No. WO2007 / 011066

[Patent Document 2] Japanese Unexamined Patent Publication No. 2007-291102

[Patent Document 3] Japanese Unexamined Patent Publication No. 2008-169196 30

[Patent Document 4] Japanese Unexamined Patent Publication No. 2008-255020

[Patent Document 5] Japanese Unexamined Patent Publication No. 2008-260721

[Patent Document 6] Japanese Unexamined Patent Publication No. 2009-040690

[Patent Document 7] Japanese Unexamined Patent Publication No. 2009-249306

[Non-patent documents]

0010.

[Non-Patent Document 1] "The Journal of Clinical Investigation", Shi

Uniter S.L. et al., Vol. 67, pp. 1630-1635 (1981)

[Summary of Invention]

[Problems to be Solved by the Invention] 40

0011

The present invention has been made in view of the current state of the art, and is a human that appears with aging.

A new anti-treatment to prevent or improve changes in skin wrinkles, fine wrinkles, age spots, slacks, etc.

Provided are a composition for external use of skin for Ising, basic cosmetics containing the same, and a method for producing them.

That is the subject.

[Means for solving problems]

[0012]

As a result of diligent research efforts to solve the above problems, the present inventors have made L-ascorbic acid.

, The derivatives thereof, and their salts have an excellent anti-aging effect, ie, turn-o

Bar improvement, maintenance or enhancement of barrier function in the skin, and hyaluronic acid production in the skin 50
 (6) JP 2018-90631 A 2018.6.14

Wrinkles, fine wrinkles, age spots, and loosening of the skin with aging by exerting the effect of maintaining or enhancing

In addition to finding that it exerts an anti-aging effect that prevents or improves only

The external composition for skin that exerts the above-mentioned effect is the above-mentioned L-ascorbic acid, a derivative thereof, or a composition thereof.

It can be easily manufactured by a manufacturing method including a step of mixing a salt with an aqueous medium as a base.

The present invention was completed by finding that it could be done.

0013

That is, the present invention solves the above problem by using an aqueous medium as a base and using L-ascol as an active ingredient.

Anti-e containing one or more selected from binic acid, its derivatives, and salts thereof

Topical skin composition for Ising and basic cosmetics containing the skin composition for anti-aging

It is solved by providing. In addition, the present invention solves the above problems with L-ascor. Ten

With one or more selected from binic acid, derivatives of L-ascorbic acid, and salts thereof

, An anti-aging skin external composition comprising the step of mixing with an aqueous medium as a base, or

It is solved by providing a method for manufacturing basic cosmetics.

0014.

The active ingredients of the anti-aging external composition for skin and basic cosmetics of the present invention are basically.

It is L-ascorbic acid. However, L-ascorbic acid is reducing and extremely unstable.

Because it is easy to lose physiological activity, L-ascorbic acid is more than L-ascorbic acid itself.

Derivatives are more preferably used. L-ascorbic acid or its derivatives are also in the form of salts

It may be. From the salt of L-ascorbic acid, L-ascorbic acid is idle in the aqueous medium.

When separated, the L-ascorbic acid derivative is released from the salt of the L-ascorbic acid derivative in an aqueous medium. 20

The liberated and liberated L-ascorbic acid derivative is a human organism when applied to human skin.

L-ascorbic acid is further liberated by the action of the enzymes present in. Therefore, the book

In the anti-aging skin external composition and basic cosmetics of the present invention, L-ascorbin

In addition to acids, derivatives of L-ascorbic acid, salts of L-ascorbic acid, and L-ascor

One or more selected from salts of biacid derivatives are age-related skin wrinkles and fine wrinkles.

Used as an active ingredient with anti-aging effect to prevent or improve spots, slacks, etc.

Will be done.

0015.

As the derivative of L-ascorbic acid, the glycosyl derivative of L-ascorbic acid and phragmites auspicus

Lubricated derivatives or phosphorylated derivatives are preferably used, and among them, L-ascorbic acid grease. 30

2-O-α-D-glucosyl-L-ascorbic acid, which is a cosyl derivative, or its natriu

Mu salt is extremely stable and remarkable when blended in the external composition for skin or basic cosmetics of the present invention.

Since it exhibits an anti-aging effect, it is more preferably used.

0016.

2-O-α-D-glucosyl-L-ascorbic acid and its sodium salt are each

It is preferable to use the one in the crystalline form. Suitablely used 2-O-α-D-glucosi

As the crystal of lu-L-ascorbic acid, for example, the same applicant applied for Japanese Patent Application Laid-Open No. 3-135992.

2-O-α-D-glucosyl-L disclosed in Japanese Patent Application Laid-Open No. 2012-67013, etc.

-Ascorbic acid anhydrous crystal-containing powder can be mentioned.

[0017] 40

On the other hand, as crystals of the sodium salt of 2-O-α-D-glucosyl-L-ascorbic acid

In powder X-ray diffraction, the diffraction angles (2θ) are 6.8 °, 8.2 °, 14.3 °, 17.8.

Hydrous crystals showing diffraction peaks at ° and 18.4 °, or diffraction angles (2θ) 8.0 °, 9.

Anhydrous crystals showing diffraction peaks at 0 °, 16.4 °, 17.9 °, and 20.8 ° can be mentioned.

To. Hydrous crystals of the sodium salt of these 2-O-α-D-glucosyl-L-ascorbic acid

And anhydrous crystals are novel crystals created by the present inventors, and can be highly purified by crystallization.

Since it is easy, it has the advantage that its physical properties, effectiveness, and safety can be easily confirmed.

Therefore, it is possible to prepare a high-purity product relatively easily and use it as an active ingredient.

It has the above-mentioned advantage and can be particularly preferably used as an active ingredient in the present invention.

0018 50
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By the way, 2-O-α-D-glucosyl-, which is a glycosyl derivative of L-ascorbic acid.

L-ascorbic acid shows relatively strong acidity in aqueous media, which is applied to human skin

When blended in external preparations for skin or cosmetics, the pH is usually 5 with an appropriate alkali.

A step of neutralizing to about 9 is indispensable. However, the above-mentioned 2-O-α-D

-The hydrous crystals and anhydrous crystals of the sodium salt of glucosyl-L-ascorbic acid are in an aqueous medium.

2-O-α-D-glucosyl-L-ascorbic acid and its nato because it is alkaline.

When used in combination with rum salt crystals, adjust the mixing ratio of both as appropriate.

Without neutralizing 2-O-α-D-glucosyl-L-ascorbic acid with Lucari

It is said that an external composition for skin or basic cosmetics having a pH within a desired range can be produced.

Very good benefits are obtained. When both are used together, the pH after mixing with the aqueous medium is predicted. Ten

2-O-α-D-glucosyl-L-as in advance so that it is within the specified range.

Hydrous crystals and / or anhydrous crystals of corbic acid and its sodium salt were blended in an appropriate ratio.

It is convenient to use as a composition. In addition, for example, the pH is alkaline like face wash.

In the case of topical skin compositions or basic cosmetics, 2-O-α-D-glucosyl-

2-O-α-D-glucosyl-L-ascorbi without use with L-ascorbic acid

Only hydrous crystals and / or anhydrous crystals of the sodium salt of the acid may be used as the active ingredient.

Of course.

0019

The external composition for skin of the present invention can be used alone as an external composition for anti-aging.

Although it can be used, various basic cosmetics are added by adding appropriate cosmetic ingredients that are widely used. 20

It is preferable to use as. For example, the external composition for anti-aging skin of the present invention is

Ethanol and a moisturizer may be added to this to make a lotion, and this lotion is further added.

One or more astringents, keratin softeners, emollients, or surfactants, respectively

You may match. In addition to such lotions, one or more fragrances, pigments, and preservatives, respectively.

It is also optional to add agents, fungicides, UV absorbers, metal sequestering agents, or buffers.

0020

In addition, the external composition for skin for anti-aging of the present invention is an alkaline salt of a higher fatty acid.

(Soap) may be added to make a facial cleanser, and each of these facial cleansers has one or more scents.

Agents, pigments, antioxidants, or metal sequestering agents may be added. In addition to such facial cleansers,

Of course, lyserine, ethanol, sugar, polyhydric alcohol, or disinfectant may be added. 30

Is.

0021.

The anti-aging skin external composition of the present invention contains a moisturizer and an emollient.

It may be used as a beauty essence, and each of these beauty essences contains one or more fragrances and ultraviolet rays.

A collector, whitening agent, anti-inflammatory agent, preservative, or bactericidal agent may be added. In addition, the anti of the present invention

The external composition for aging is made into a milky lotion by adding an appropriate oily component and surfactant to the composition.

In this emulsion, one or more appropriate moisturizers and emollients, respectively, may be used.

A blood circulation promoter or a polymer substance may be blended. Furthermore, the anti-aging skin of the present invention

The composition for external use may be made into a cream by adding an appropriate oily component and a surfactant to the composition.

This cream contains whale wax, cetanol, lanolin, liquid paraffin, petrolatum, glyce 40

Phosphorus or squalane may be appropriately added.

0022.

The turnover improvement referred to in the present invention means "stratum corneum (stratum corneum)", "granular layer", and "yes".

Epidermal cells (keratinocytes) that are the source of human epidermis composed of "stratum spinosum" and "basal layer"

It is intended to keep the series of processes (turnover) of proliferation, migration, differentiation, and shedding in a healthy state.

To taste. More specifically, to improve the rate of skin turnover, which decreases with age.

means.

[0023]

Further, the maintenance or enhancement of the barrier function in the skin referred to in the present invention is referred to as in the skin.

A machine of the stratum corneum called the secondary barrier, which is contrasted with the function of the sebaceous membrane called the loose primary barrier 50
 (8) JP 2018-90631 A 2018.6.14

Noh, that is, the invasion of foreign substances from outside the body into the body and the excessive release of water from inside the body to the outside of the body.

Tight junctions present in the stratum granulosum of the epidermis adjacent to the stratum corneum

Maintains or enhances the function of separating the inside and outside of the living body by an intercellular adhesion structure called TJ)

Means to do. By the way, the stratum corneum is a layer composed of multiple layers of stratum corneum.

The outermost layer of the stratum corneum has a cornified envelope (CE) that protects the inside of the stratum corneum.

There is a strong membrane composed of various proteins such as involucrin called. Previous

Note CE and TJ play an important role in the barrier function in the skin. On the skin

When the barrier function in the area is reduced, ultraviolet rays, especially long-wavelength A waves that reach the dermis, cause

Collagen, elastin, hyaluronic acid, etc. present in the dermis are damaged. Also,

When the barrier function of the skin deteriorates, the skin becomes dry and excessive secretion of sebum is promoted. Ten

It is also known to induce millet and disturb turnover. With aging

, The barrier function on the skin is reduced, which causes wrinkles, fine wrinkles, age spots, slacks, etc. on the skin.

Is evoked.

0024

Furthermore, the maintenance or enhancement of hyaluronic acid production referred to in the present invention means hyaluronic acid in the skin.

It means increased production of hyaluronic acid from producing cells, thereby barriers in the skin.

The function is maintained and enhanced, and an anti-aging effect is brought about.

0025

In addition, the suppression of glycation reaction referred to in the present invention means that reducing sugars such as glucose and fructose are used in the dermis.

It binds non-enzymatically to (collagen) and stratum corneum (keratin), and with advanced glycation end products (AGEs) 20

Suppressing the reaction that produces a substance called (also called Maillard reaction or browning reaction)

Means that. AGEs cause skin aging such as wrinkles, rough skin, dullness, or reduced elasticity.

It is known to bring.

【The invention's effect】

0026

According to the anti-aging skin external composition of the present invention or the basic cosmetics containing the same,

Effectively prevent or improve age-related skin changes such as wrinkles, fine wrinkles, age spots, and looseness.

You get the great advantage of being able to. In particular, as an active ingredient, L-ascorbic acid

2-O-α-D-glucosyl-L-ascorbic acid, which is a glycosyl derivative of

When thorium salt is used, the active ingredient in the prepared external composition for skin or basic cosmetics 30

Is extremely stable and exerts a remarkable anti-aging effect when applied to the skin

The excellent advantage is obtained. In addition, 2-O-α-D-glucosyl-L-ascorbic acid and

And / or when using a sodium salt thereof in crystalline form, it is contained in the raw material.

Extremely high purity 2-O-α-D-glucosyl-L-ascorbin by eliminating impurities as much as possible

Acids and / or sodium salts thereof may be used as active ingredients in topical skin compositions or basic cosmetics.

Because it can be done, it has the advantage of being extremely safe and can be applied to the skin with peace of mind.

Be done. Further, the anti-aging external composition for skin of the present invention or a foundation containing the same.

2-O-α-D-glucosyl-L-ascorbic acid and its natri in the manufacture of cosmetics

When um salt is used in combination, 2-O-α-D-glucosyl-L when mixed with an aqueous medium

-Ascorbic acid is relatively strongly acidic, whereas its sodium salt is alkaline. 40

Therefore, by appropriately considering the ratio of the two, 2-O-α-D-g using alkali is used.

Topical skin with pH in the desired range without neutralizing lucosyl-L-ascorbic acid

The advantage of being able to produce agents or basic cosmetics is obtained.

[Simple explanation of drawings]

[0027]

FIG. 1 is a photomicrograph of ascorbic acid 2-glucoside-sodium salt crystals (hydrous crystals).

is there.

FIG. 2 is a photomicrograph of ascorbic acid 2-glucoside-sodium salt crystals (anhydrous crystals).

is there.

FIG. 3 shows anhydrous crystals of ascorbic acid 2-glucoside-sodium salt and ascorbic acid 2-. 50
 (9) JP 2018-90631 A 2018.6.14

It is a figure which compared the infrared absorption spectrum of a glucoside anhydrous crystal.

FIG. 4 is a hydrous crystal of ascorbic acid 2-glucoside-sodium salt, ascorbic acid 2-

Anhydrous crystals of glucoside-sodium salt, ascorbic acid 2-glucoside hydrous crystals, and

It is a figure which compared the powder X-ray diffraction pattern of the ascorbic acid 2-glucoside anhydrous crystal.

FIG. 5 is a single crystal X-ray diffraction pattern of a hydrous crystal of ascorbic acid 2-glucoside-sodium salt.

Is.

BEST MODE FOR CARRYING OUT THE INVENTION

[0028]

The present invention uses an aqueous medium as a base, and uses L-ascorbic acid as an active ingredient, a derivative thereof, and

And an external composition for anti-aging skin containing one or more selected from those salts Ten

Products, basic cosmetics containing such anti-aging external composition for skin, and their manufacture.

It is about the manufacturing method. Hereinafter, first, the composition for external skin for anti-aging of the present invention

The basic cosmetics of the present invention and a method for producing them will be described subsequently.

[0029]

A. Topical skin composition for anti-aging

The anti-aging external composition for skin of the present invention (hereinafter, simply referred to as "external skin composition".

) Is one or more selected from L-ascorbic acid, its derivatives, and salts thereof.

Is contained as an active ingredient. L-ascorbic acid enters the body as vitamin C

While performing important physiological functions, it is also used as an antioxidant and anti-inflammatory agent, and

Since it has a whitening effect and a collagen production enhancing effect, it has been useful in the cosmetics field as well. 20

It is a compound that is widely used as an ingredient. L-ascorbic acid is added to the external composition for skin

As a result, wrinkles, fine wrinkles, stains, and slack can be effectively prevented or ameliorated.

It can be used as an active ingredient in a composition for external use on the skin.

[0030]

However, L-ascorbic acid is extremely unstable due to its reducing property and is oxidized.

It has the disadvantage that it is easily decomposed and loses its physiological activity. Therefore, L-ascorbin

Acids require great care in storage and handling, and are also used in cosmetics and other external compositions for skin.

If so, far exceed the original required amount in anticipation of the amount that will be oxidatively decomposed by the time of use.

It is necessary to mix the amount. Therefore, it is used as an active ingredient in the external composition for skin of the present invention.

It is more stable than L-ascorbic acid itself and is L-ascorbi in vivo. 30

A derivative of L-ascorbic acid that liberates the acid and exerts the original function of L-ascorbic acid.

Or the salt thereof is more preferably used.

0031

Derivatives of L-ascorbic acid suitable as the active ingredient of the external composition for skin of the present invention are derived.

The body itself is more stable than L-ascorbic acid and releases L-ascorbic acid in vivo

As long as the original function of L-ascorbic acid is exhibited, it is particularly limited.

There is no. L-ascorbin that can be used as an active ingredient of the external composition for skin of the present invention

Examples of the acid derivative include a glycosyl derivative of L-ascorbic acid and L-ascorbi.

Examples thereof include an acylated derivative of an acid and a phosphorylated derivative.

[0032] 40

As a glycosyl derivative of L-ascorbic acid, it is located at the 2-position of L-ascorbic acid.

Derivatives to which a glycosyl group is attached have high stability and are therefore preferably used. With such derivatives

Then, for example, Japanese Patent Application Laid-Open No. 3-135992, Japanese Patent Application Laid-Open No. 3-139288, etc.

Glycosyl group, maltosyl group, maltotri at the 2-position position of the disclosed L-ascorbic acid

2-O-α-glycosyl-L-asco with α-bonded series of glycosyl groups such as oscil group

Rubic acid (ascorbic acid 2-glycoside) and, for example, JP-A-6-263790.

2-O- with a β-bonded galactosyl group at the 2-position position of L-ascorbic acid disclosed in

β-D-galactosyl-L-ascorbic acid (2-galactoside ascorbic acid) etc.

Can be mentioned.

0033 50
 (Ten) JP 2018-90631 A 2018.6.14

Further, as an acylated derivative of L-ascorbic acid (fatty acid ester derivative), for example.

For example, Japanese Patent Application Laid-Open No. 59-10505, Japanese Patent Application Laid-Open No. 63-104971, JP-A-6-24

Ascorbic acid disclosed in Japanese Patent Application Laid-Open No. 7956, JP-A-2004-331524, etc.

Palmitic acid ester, ascorbic acid-dipalmitic acid ester, ascorbic acid-te

Trahexyl decanoic acid ester, ascorbic acid-cholesterol ester, etc.

As a phosphorylated derivative of L-ascorbic acid, for example, JP-A-61-152613

No., JP-A-5-339123, JP-A-2002-3330, JP-A-2006

-Ascorbic acid 2-phosphate and various metals disclosed in Japanese Patent Publication No. 63060

Examples include salt.

0034 Ten

Among the various derivatives of L-ascorbic acid described above, the glycosyl of L-ascorbic acid

Derivatives have high stability and are most preferably used. Among them, the position of the 2-position of L-ascorbic acid

2-O-α-D-glucosyl-L-ascorbic acid with α-bonded glucosyl group to

, In the present specification, abbreviated as "ascorbic acid 2-glucoside". ) Is the most suitable. A

Scorbic acid 2-glucoside was developed to eliminate the above-mentioned drawbacks of L-ascorbic acid.

It is a derivative of L-ascorbic acid, which does not show direct reducing property, is stable, and is a living body.

Inside, it is decomposed into L-ascorbic acid and D-glucose by in vivo enzymes and L-ascor.

It has an epoch-making property that it exerts the original physiological activity of corbic acid. Ascorbic acid

For 2-glucoside, for example, JP-A-3-135992, JP-A-3-139288

As disclosed in the publications, sugar transfer fermentation is performed in a solution containing L-ascorbic acid and starch. 20

Cyclomaltodextrin glucanotransferase is allowed to act as an element, and then

By the method of allowing glucoamylase to act on the obtained 2-glycoside ascorbic acid,

Can be manufactured on a commercial scale.

0035.

The ascorbic acid 2-glucoside is preferably in the form of crystals in part or in whole.

Used for. That is, the percentage of crystals in the total ascorbic acid 2-glucoside used

The larger the number, the higher the purity and the stable physical properties, so it is preferable, but it is not always used.

The entire scorbic acid 2-glucoside does not have to be in full crystalline form, even some amorphous

It may be a crystal-containing powder in which the above is mixed. Anhydrous crystals in ascorbic acid 2-glucoside

2-glucos ascorbic acid, which is known to exist and can be suitably used in the present invention. 30

Examples of sid crystals include the above-mentioned Japanese Patent Application Laid-Open No. 3-135992 and International Publication No. WO201.

2-O-α-D-Glucosyl-L-Asco disclosed in Pamphlet 2/121297

Examples include powder containing anhydrous rubic acid crystals, and commercially available products include cosmetics and quasi-drug materials.

Ascorbic acid 2-glucoside anhydrous crystal-containing powder (trade name "AA2G")

, Hayashibara Sales Co., Ltd.) exists.

0036

L-ascorbic acid used as an active ingredient in the external composition for skin of the present invention.

Alternatively, the derivative of L-ascorbic acid may be L-ascorbic acid or when mixed with an aqueous medium.

As long as the derivative of L-ascorbic acid is dissociated, it may be in the form of a salt.

0037 40

As a salt particularly preferably used as an active ingredient in the external composition for skin of the present invention, a.

Examples include the sodium salt of 2-glucoside of ascorbic acid. Ascorbic acid 2-glucosi

The sodium salt of the salt is, for example, an aqueous solution of ascorbic acid 2-glucoside and sodium hydroxide.

It can be obtained by neutralizing with an alkali such as mu, and then drying. Asco

The sodium salt of 2-glucoside rubic acid, when dissolved in an aqueous medium, is low, depending on the pH.

At least part of it dissociates into ascorbic acid 2-glucoside and sodium, so ascor

Like corbic acid 2-glucoside, it can be used particularly preferably in the present invention.

[0038]

The sodium salt of ascorbic acid 2-glucoside is ascorbic acid 2-glucoside.

Like do, it is more preferred to use in crystalline form. Ascorbic acid 2-glucoside 50
 (11) JP 2018-90631 A 2018.6.14

The sodium salt crystals of are novel crystals created by the present inventors. That is, Ascol

Regarding the crystals of the metal salt of 2-glucoside, aluminum salt and zinc salt have been combined so far.

Crystalline powder has been reported in JP-A-6-22081, but it is related to sodium salt crystals.

There is no report. Incidentally, in the above publication, ascorbic acid 2-glucoside

And the aluminum compound are dissolved in cold water, stirred and centrifuged, and then the supernatant is lyophilized or dried.

NaOH is added to the zinc compound, and after stirring and centrifugation, the obtained precipitate is ascorbic acid 2-.

By adding to an aqueous solution of glucoside, filtering, and then freeze-drying the filtrate, each ass

It is said that a crystalline powder of aluminum salt or zinc salt of 2-glucoside corbic acid was obtained.

There is. However, we found that the sodium salt of ascorbic acid 2-glucoside was formed.

The same method as in the above publication was repeated in order to obtain crystals, but crystals of aluminum salt or zinc salt were obtained. Ten

No ascorbic acid 2-glucoside by any method allegedly resulting in a sex powder

A crystalline powder of thorium salt could not be obtained.

[0039]

As a result of further research and trial and error, the present inventors unexpectedly assaulted.

Add an excess amount of sodium hydroxide as an aqueous solution to 2-glucoside corbic acid and dissolve it alkaline.

After making a liquid, ascorbi is added to this alkaline solution and allowed to stand.

We succeeded in obtaining crystals of acid 2-glucoside-sodium salt.

0040

As shown in the experiments described later, ascorbic acid 2-glucoside na, which was found by the present inventors.

Thorium salt crystals can take either hydrous or anhydrous crystals and ascorbic acid. 20

Hydrous crystals of 2-glucoside-sodium salt have a diffraction angle (2θ) 6 in powder X-ray diffraction.

.. Diffraction peaks characteristic of 8 °, 8.2 °, 14.3 °, 17.8 °, and 18.4 °

Anhydrous crystals of ascorbic acid 2-glucoside-sodium salt are found in powder X-ray diffraction.

, Diffraction angle (2θ) 8.0 °, 9.0 °, 16.4 °, 17.9 °, and 20.8 °

Diffraction peak. In addition, the present inventors, ascorbic acid 2-glucoside-natriu

Succeeded in obtaining a single crystal of a size capable of X-ray crystal structure analysis for the hydrous crystal of the salt.

Then, as shown in the experiment described later, the hydrous crystal became an orthorhombic crystal by X-ray crystal structure analysis.

It belongs, the space group is Pbca (# 61), the lattice constant is a = 6.9733Å, b = 14.483.

It has been clarified that the crystal shows 9 Å and c = 19.3221 Å.

[0041] 30

Incidentally, according to the inductively coupled plasma emission spectroscopic analysis described later, the sodium salt is anhydrous.

The sodium content in the crystals was about 8.7% by weight. On the other hand, the anhydrous crystal is Asco.

It consists of 2-glucoside rubic acid, sodium and sodium hydroxide, and the amount ratio is ascor.

Sodium is 1 atom and sodium hydroxide is (1 /) for 1 molecule of 2-glucoside biacid.

2) Assuming that it is a molecule, the theoretical value of sodium content is 8.8% by mass, which is the measured value.

Very well matched. At this time, the molar ratio of ascorbic acid 2-glucoside to sodium is

Approximately 1: 1.5, 3 sodiums for every 2 ascorbic acid 2-glucosides

Will be included. Further, as shown in the measurement result of water content described later, ascorbic acid 2-

The water content of the sodium salt of glucoside in the water-containing crystals is about 15% by mass, and the water content is such.

Crystals turn ascorbic acid 2-glucoside, sodium and sodium hydroxide into anhydrous crystals 40

The molar ratio of ascorbic acid 2-glucoside to water molecules, assuming the same molar ratio

Is about 1: 4, and the number of hydrous crystals is 4 molecules per 1 molecule of ascorbic acid 2-glucoside.

It can be said that it contains water of crystallization.

[0042]

Generally, organic compounds are said to exhibit polymorphism, and even the same compound has multiple differences.

Crystal structure can be taken, and depending on the difference in the crystal structure, each of them including solubility

Species properties may differ. For this reason, organic compounds are used, for example, in external composition for skin and basic cosmetics.

When used as an active ingredient in, the physical properties suitable for the intended use are stably maintained and secured.

Therefore, if a crystal is present in the organic compound, the crystal is obtained, and further, the crystal structure thereof.

It is extremely useful to clarify. The external composition for skin or basic cosmetics of the present invention 50
 (12) JP 2018-90631 A 2018.6.14

, Ascorbic acid 2-glucoside sodium salt is used as a suitable active ingredient.

However, nowadays, the present inventors have crystallized the sodium salt of ascorbic acid 2-glucoside.

Was obtained, and it became clear that anhydrous crystals and hydrous crystals existed in the crystals.

Since the powder X-ray diffraction pattern and the crystal structure that characterize the above have been analyzed, the above anhydrous crystal or

When using the sodium salt of ascorbic acid 2-glucoside in the form of hydrous crystals

In addition to the advantage that high-purity materials can be easily prepared, their handleability and effectiveness

It is possible to easily confirm the properties and safety, and always expect constant known and stable physical properties.

You get the very good advantage of being able to.

[0043]

The method for producing ascorbic acid 2-glucoside-sodium salt crystals used in the present invention is intended. Ten

As long as the crystals of the above can be obtained, the present invention is not particularly limited, but for example, 2-g ascorbic acid.

After dissolving Lucoside in an aqueous sodium hydroxide solution, add an organic solvent and let stand.

By precipitating crystals and then recovering the crystals using a solid-liquid separation method such as centrifugation.

Therefore, hydrous crystals of ascorbic acid 2-glucoside-sodium salt can be obtained. this

At times, it is desirable to use high-purity ascorbic acid 2-glucoside used as a raw material.

Generally, the purity is 90% by mass or more, preferably 95% by mass or more, and more preferably 99 quality.

It is preferable to use ascorbic acid 2-glucoside anhydrous crystals in an amount of% or more as a raw material.

[0044]

The obtained hydrous crystals are washed with hydrous ethanol to obtain high-purity hydrous crystals.

Can be done. The obtained hydrous crystals are crushed and dried as necessary to ascorbi. 20

It can be a water-containing crystal-containing powder of acid 2-glucoside-sodium salt. Also, the above

Ascorbic acid 2 is obtained by vacuum-drying the hydrous crystals obtained by the above method while heating.

-Can be converted to anhydrous crystals of glucoside-sodium salt. In addition, the obtained anhydrous

Crystals can be converted into hydrous crystals again by absorbing moisture under conditions of relative humidity of 75% or more.

Can be done. Further, a mass kit obtained by adding an organic solvent to precipitate crystals.

Contains ascorbic acid 2-glucoside-sodium salt hydrous crystals by spray-drying

Powders or anhydrous crystal-containing powders can also be obtained.

0045

One of the characteristics of anhydrous crystals or hydrous crystals of ascorbic acid 2-glucoside-sodium salt

Therefore, when the anhydrous crystal or the hydrous crystal is dissolved in water, the obtained aqueous solution is alkaline. 30

Is mentioned. This is because ascorbic acid 2-glucoside anhydrous crystals are dissolved in water.

This is in sharp contrast to the fact that the obtained aqueous solution shows relatively strong acidity. For this reason, this

The new ascorbic acid 2-glucoside-sodium salt crystals created by Meisha et al.

In 2-glucoside anhydrous crystals of scorbic acid, the amount used because the aqueous solution shows relatively strong acidity.

It can also be suitably used in applications where the usage itself is limited.

For example, a soap-based external composition for skin that requires weak alkalinity, such as soap and shampoo.

When used for facial cleansing foam, body soap, etc., conventional ascorbic acid 2-glucosi

When using anhydrous crystal-containing powder, ascorbic acid 2-glucoside dissolved in an aqueous medium

It is essential to neutralize the acidic solution of the above with alkali in advance and add a buffer for pH adjustment.

However, the aqueous solution obtained by dissolving ascorbic acid 2-glucoside-sodium salt crystals is 40

, Usually shows alkalinity, so when blending into the external composition for skin, alkali is used.

Therefore, there is no need to neutralize ascorbic acid 2-glucoside, and there is no need to use a buffer.

In many cases.

[0046]

In addition, anhydrous crystals or hydrous crystals of ascorbic acid 2-glucoside-sodium salt are added to the ascorbate.

When used in combination with corbic acid 2-glucoside anhydrous crystals, the mixing ratio of both should be adjusted.

Therefore, the pH when dissolved in an aqueous medium is within a predetermined range, for example, weakly alkaline.

It is said that an aqueous solution of ascorbic acid 2-glucoside within the range of extremely weak acidity can be obtained.

Benefits can be obtained. Therefore, anhydrous ascorbic acid 2-glucoside-sodium salt

When crystals or hydrous crystals are used in combination with ascorbic acid 2-glucoside anhydrous crystals, a. 50
 (13) JP 2018-90631 A 2018.6.14

For alkalis other than anhydrous crystals or hydrous crystals of 2-glucoside-sodium salt of ascorbic acid

The external composition for skin and the basis of the present invention without neutralizing ascorbic acid 2-glucoside.

Various sets in which the overall pH, including cosmetics, is preferably in the range of weak alkalinity or weak acidity.

The advantage of being able to produce an adult is obtained. When using both together,

During the production of various compositions, ascorbic acid 2-glucoside anhydrous crystals and ascorbic acid 2-

The amount of anhydrous crystals or hydrous crystals of glucoside-sodium salt according to the mixing ratio of each.

It may be weighed and used, but depending on the pH required for the target composition, a

Scorbic acid 2-glucoside anhydrous crystals and ascorbic acid 2-glucoside-sodium salt

A composition in which anhydrous crystals or hydrous crystals are blended in a predetermined blending ratio, preferably in terms of anhydrous quality.

It is convenient to prepare the composition in a blending ratio of 60:40 to 45:55 in quantity ratio. Ten

In addition, ascorbic acid 2-glucoside to be blended in the external composition for skin and basic cosmetics of the present invention.

-Anhydrous or hydrous crystals of sodium salt, or 2-glucoside anhydrous crystals of ascorbic acid

The blending amount is the total in terms of L-ascorbic anhydride, and is usually used for external skin compositions and basic makeup.

0.001% by mass or more, preferably 0.01 to 50% by mass, more preferably per mass of the product.

Is 0.1 to 20% by mass, and more preferably 1 to 10% by mass. The above formulation

If it is below the lower limit of the amount, or if it exceeds the upper limit of the compounding amount, the expected effect is significantly reduced.

It is not preferable because it may not be possible to exert it.

[0047]

As described above, the active ingredient of the external composition for skin of the present invention is 2-glue ascorbic acid.

Coside and / or a sodium salt thereof can be preferably used. Ascorbic acid 2-gu 20

The sodium salt of lucoside is at least partly ascorbic acid 2-gluco in an aqueous medium

It dissociates into sid and sodium to produce ascorbic acid 2-glucoside. Also, Asco

Rubic acid 2-glucoside is an in vivo enzyme of in vivo enzymes such as α-glucosidase.

By action, it is hydrolyzed to L-ascorbic acid and D-glucose, and L-ascorbin

It functions as an acid. Therefore, in the external composition for skin of the present invention, α-, if necessary.

L-ascorbic acid when applied to the skin by adding a glucosidase inhibitor

Can delay the production of and make its anti-aging effect persistent or lagging

.. On the contrary, an α-glucosidase activator is added to the external composition for skin of the present invention as needed.

By combining, it accelerates the production of L-ascorbic acid when applied to the skin, and has an immediate effect on the effect.

It can also have sex. 30

0048

As the α-glucosidase inhibitor, both antagonistic and non-antagonistic inhibitors are used.

As specific α-glucosidase inhibitors, maltotriose and malto can be used.

Starch hydrolysis of tetraose, maltopentaose, maltoheptaose, panose, etc.

Things; Maltitol, Martotriitol, Martote Tritor, Martopentitol

, Maruto Hexaitol, Marto Heptitol, Erythritol, 1-thio-D-Guru

Sugar alcohols such as citole; arabinose, fucos, 2-deoxy-D-galacto-

S, xylose, ribose, tagatous, libros, lixose, xylose, α-

Monosaccharides such as methyl-D-xylosine; ori such as fucoidan-derived oligosaccharides and soybean-derived polysaccharides

Gosaccharides or polysaccharides; nu such as adenylic acid, guanylic acid, cytidinelic acid, uridinelic acid, inosinic acid 40

Cleothide; guanosine, deoxyguanosine, adenosine, deoxyadenosine, nucleotide

Nucleoside such as gin, uridine, inosine, deoxyinosin; Panax ginseng, a

Roevera, Hypericum, Mallow, Sarachi Areti Clata, Connarsco Kinensis

, Sapium Disco, Xantopulmu Annamense, Paris Tetraphylla, Dimocal

Puslongan, Erythroxylon cambody anum, Diospyros malavalica, Tow

Chi, Carreya Arborea, Mulberry, Semekalpskokinkinensis, Caropulum Caraba,

Solaire Guiso, Duavangason Neratioides, Kratoxylon Formosum, Al

Kidendron Turgidum, Now Claire Offikinaris, Eupatorium Odratu

Mu, Hibiskus Mesnui, Milkia Cefaero Carpe, Milletia Diptera, Mi

Alletia Konraui, Ascopurumnodosum, Brukeayabanica, Mangiferai 50

 (14) JP 2018-90631 A 2018.6.14

Ndikia, Cesbania Grandiflora, Gliculi Sauralensis, Lumexbuke

Paloporus, Murtexcommunis, Tarakusakumu Offikinare, Bisukumu Albam,

Ganoderma Lucidum, Pinus Densiflora, Penalus Skulsey, Origanum Mayora

Na, Grifora Frondosa, Sangji Ramurusmori, Lobelia Kinensis, Angelica acutiloba, Shi

Zigium Aromaticum, Kommerina Kommunis, Saraki Areti Kurata, Eucommia

Urmoides, Angulocalux Bowty Quaneus, Arachniodes Standici

B, laurel, gabber, hanaba, chestnut astringent skin, peanut astringent skin, extracts of plants such as black rice, etc.

Can be mentioned.

[0049]

The α-glucosidase activator includes Arnica, chamomile flower, sage, and large. Ten

Plant extracts such as beans and mugwort, and microbial extracts such as yeast, bifidobacteria, and lactic acid bacteria are listed.

You can get rid of it.

0050

L-ascorbic acid, derivatives of L-ascorbic acid, and salts thereof used in the present invention

In itself, it has a turnover improving effect, a maintenance or enhancement effect on the barrier function in the skin, and

And because it exerts the effect of maintaining or enhancing hyaluronic acid production in the skin, the present invention alone

Although it can be advantageously used as an active ingredient in the external composition of the skin of the present invention,

In the composition for use, if necessary, a plant extract or a plant extract having an effect of improving skin turnover, which will be described later.

When compounded, L-ascorbic acid and L-ascorbin as active ingredients

In addition to the above-mentioned effects of acid derivatives and their salts, the anti-effects of these active ingredients 20

Wrinkle action, anti-fine wrinkle action, whitening action, anti-stain action, anti-slack action exceed the additive effect

L-ascorbic acid and L-ascorbi used in the present invention

Turnover improving effect and burrs on the skin exerted by acid derivatives and their salts

A. Prevents the maintenance or enhancement effect of function and the maintenance or enhancement effect of hyaluronic acid production in the skin.

The concomitant use of the plant extract or compound is particularly useful in the practice of the present invention.

is there.

0051

(Plant extract or compound having skin turnover improving effect)

Examples of the plant extract or compound having a skin turnover improving effect include sesame and geo.

C, peach, licorice, cactus, wheat germ, wild strawberry, sage, mint, pepper 30

Mint, Houttuynia cordata, Cat's claw, Perilla, Loquat, Camellia, Taisou, Ai, Akebi, A

Shitaba, Asunaro, Acerola, Artea, Aloe, Ginkgo, Oubaku, Hypericum,

Olives, oranges, chamomiles, quince seeds, grapefruits, cinnamon, shell ginger, ji

Yu, white hippopotamus, star fruit, assembly, sohakuhi, cha, chouji, carrot, ha

Mamelis, Rose, Himalayan Raspberry, Butcher Bloom, Prunes, Buttonpi, Ma

Ronnier, evening primrose, cornflower, eucalyptus, saxifraga, yuzu, yokunin, la

N, lemon, astragalus, rose hip, rosemary, cherry, hibamata, roudoku, ki

Nkaran, Jashoushi, Bold, Hima, Sassafrasunoki, Angelica, Zuikouro

Udoku, oak, oak, balsam, impatiens, forsythia, alfalfa

, Motsuyakuju, Queens Delight, Hikagenokazura, Tokinsou, Jasho, 40

Fig, Magnolia, Yulan Magnolia, Birch, Usba Akaza, Honeysuckle, Gardenia jasminoides

, Plant extracts such as tounin, taiso, seaweed, chlorella, royal jelly, chimpi,

Carnitine, nicotinamide, pyridoxine hydrochloride, hyaluronic acid, glycolic acid, k

Enic acid, lactic acid, malic acid, tartaric acid, 2-hydroxybutyric acid, 3-hydroxybutyric acid, tartro

Acids, vitamin As, glycyrrhizic acid derivatives, allantoin, diclofenac, fel

Examples of binak, ibuprofen, ketoprofen, loxoprofen and their salts

It can be used, and one or more of them can be used in combination as appropriate. In addition, the skin

Among the plant extracts that have the effect of improving turnover, plants of the Cupressaceae family (such as Thujopsis dorsalis),

Ginkgo family plants (such as ginkgo), Mikan family plants (Oubaku, orange, grapef)

Roots, citron, lemon, etc.), Labiatae plants (mint, peppermint, perilla, rosemary) 50
 (15) JP 2018-90631 A 2018.6.14

-Etc.), Dokudami family plants (Dokudami etc.), and Tochu family plants (Tochu etc.)

The extract of is preferably used. Among them, asunaro extract, ginkgo extract, phellodendron extract

The product, orange extract, perilla extract, Houttuynia cordata extract, and Eucommia tea leaf extract will be described later.

Since it also has a saccharification reaction inhibitory effect, in the present invention, L-ascorbic acid and L-

Most preferably used in combination with derivatives of ascorbic acid and salts thereof

Can be done.

[0052]

Suitable formulation of each of the plant extracts or compounds having a skin turnover improving effect

As the amount, the external composition for skin of the present invention, or a lotion, a facial cleanser, a beauty essence containing the same,

L-ascorbic acid and L-ascorbic acid derivatives contained in milky lotion or cream Ten

, And one or more selected from those salts to 1 part by mass of the total amount (anhydrous equivalent)

However, it is usually 0.00001 parts by mass or more, preferably 0.0001 to 50 parts by mass, more preferable.

Appropriately, it is arranged in the range of 0.001 to 10 parts by mass, and more preferably 0.01 to 1 part by mass.

Will be combined. If it is below the lower limit of the compounding amount, or if it exceeds the upper limit of the compounding amount, it is expected.

It is not preferable because the effect of the above may be significantly reduced or may not be exhibited.

[0053]

L-ascorbic acid, derivatives of L-ascorbic acid, and salts thereof used in the present invention

, The effect of improving skin turnover by itself, the effect of maintaining or enhancing the barrier function in the skin,

And because it exerts the effect of maintaining or enhancing hyaluronic acid production in the skin, it is the main cause by itself.

Although it can be advantageously used as an active ingredient of Ming's external composition for skin, the external composition for external skin of the present invention 20

If necessary, the plant extract or compound having the effect of improving skin turnover may be added to the substance.

Of course, when a plant extract or compound having a saccharification reaction inhibitory action described later is blended

, L-ascorbic acid as an active ingredient, derivatives of L-ascorbic acid, and salts thereof

In addition to the above-mentioned effects of these active ingredients, the anti-wrinkle effect, anti-fine wrinkle effect, and beauty of these active ingredients

Whitening effect, anti-staining effect, anti-slacking effect can be enhanced to exceed the additive effect,

In addition, L-ascorbic acid used in the present invention, derivatives of L-ascorbic acid, and theirs.

The effect of salt on improving skin turnover, maintaining or enhancing the barrier function of the skin

Because it does not interfere with the maintenance or enhancement of hyaluronic acid production in the skin,

In the practice of the present invention, the combined use of a plant extract or a compound having an effect of improving signal over

It is especially useful. 30

0054

(Plant extract or compound having saccharification reaction inhibitory effect)

Examples of the plant extract or compound having a saccharification reaction inhibitory effect include artichoke and eye.

Bright, clearweed, Akigumi, Agni, Agni fruit, Akebi, Acai fruit, Phragmites

Uwaganda, Asunaro, Asenyakunoki, Abemaki, Jiaogulan, Anise, American

Witch hazel, Aristin, Epimedium, Japanese knotweed, Ginkgo, Pyrola japonica, Strawberry, Ito

Hayuri, Itofunori, Ficus erecta, Ipe bark, Japanese maple, Iwatoyuri, Fennel, U

Itch hazel, winter green, turmeric, plum, quercus salicina, epimedium bu

Levicornum, Agetsu, Echinacea, Echinacea, Genisteae, Elcampure, Elda

-, Elba Mate, Palmyra palm, Japanese palmyra palm, Coptis chinensis, Coptis chinensis, Oat wheat, Phellodendron amur 40

Netsukebana, Salsola komarovii, Lilium rubellum, Tiger lily, Tiger lily, Oregano, Orange, Pumpkin

Seeds, bark of cuttlefish, speciosum, guarana, karukade, wild gingers, wild gingers, kikyo

C.

Lame, pomegranate, sweet potato, sarsaparilla, hawthorn, pellionia minima, perilla, shikakuma

Me, Filipendula multijuga, Peony, Rheum palmatum, Doellingeria scabra, White goosefoot, White goosefoot

Na, Plantain, Sekisetsusou, Buckwheat, Lilium formosanum, Cardamine flexuosa, Davila le

Gosa, Tamoto lily, Cordia ecalyculata, Clove, Chinneberry senna, Centella asiatica, Daisy

, Dill, Devil Slow, Leopard Plant, Easter Lily, Devil's Claw Root, Tencha, To

Unin, Houttuynia cordata, Togenashi, Eucommia tea leaves, Tomato, Tormentilla, Curly Dock,

Elderberry, Nasturtium, Nokongiku, Mint, Brownii, Hagi, Colocasia gigantea, Passi 50

 (16) JP 2018-90631 A 2018.6.14

Young flower, passion fruit, puffia root, jackfruit, prunus campanulata, sunflower,

Himeuwabamisou, Himeyuri, Villaco, Areca nut, Japanese butterbur, Hyacinth bean, Black Kohoshi

Yu, Benibanaborogiku, Actinidia polygama, Matilus, Pine, Lithocarpus edulis, Mate tea, Madonna Li

Lee, Milk Thistle Saw Fruit, Staphylea Pinnata, Mube, Mozuku, Willow, Yabukanzo, Ya

Matgebanreishi, Golden-rayed lily, Water spinach, Aster yomena, Lychee seed, Regal Lily, Ryu

Ukyuchiku, Ryukyu rose strawberry, unripe apple fruit, linden flower, rooibos, lettuce

, Lemon, Lemongrass, Lemon Thyme, Lemon Verbena, Lemon Balm, Rosehip

, Rose Pink Butts, Rosemary, Rose Red, Laurel, Rosea, Logwood

, Waremokou, Renge grass, Persimmon leaf, Licorice leaf, Black soybean seed coat, Black rice seed, Moon peach leaf, Hosoba lily, West

Extracts of plants such as willow, eucommia leaf, tomorrow's leaf, hanafunori, owl funori, mafuno Ten

Extracts of seaweed such as li, raw coffee beans, sweet potato shochu lees, extracts of agaricus mycelium, etc.

Equol, isoflavone, 1,4-anthraquinone, 1-amino-2-hydroxyme

Chill anthraquinone, 4-aminophenol, 1,3,5-trihydroxybenzene, co

Maggot acid, 3,4-dihydroxyphenylacetic acid, caffeic acid, ifenprodil, 6-hi

Droxy-2,5,7,8-tetramethylchroman-2-carboxylic acid, 6-hydroxyi

Ndol, 7-hydroxy-4,6-dimethylphthalide, α-lipoic acid, 4-hydroxyca

Lucon, pearl protein hydrolyzate, aminoguanidine, sodium erythrosine, el

Gothioneine, resveratrol, 3,3', 5,5'-tetrahydroxystilbene, etc.

Hydroxystilbenes, oxindole, carnosine, salicylic acid, salsolino

Hydrobromide, sinapic acid, tocopheryl nicotinate, nicotinamide, nordihi 20

Drogiaretinic acid, proanthocyanins, mannitol, hydrolyzed casein, water

Degradable tannins, catechols, chlorogenic acids, isochlorogenic acids, neochlorogenic acids, chestnuts

Chlorogenic acids such as putochlorogenic acid, ferryl cafe oil quinic acid, leucociani

Examples include gin, prunin, prussianidol oligomer, glucosylrutin and the like.

Among the above ingredients, Ashwagandha, Asunaro, Asenyakunoki, Ginkgo, Wintergri

Phellodendron amur, orange, pumpkin seed, Phellodendron bark, Mallotus philippans, Glucosyl

Rutin, cowberry, perilla, buckwheat leaf, Davila rugosa, Houttuynia cordata, Himeuwabamisou, Beni

Banaborogiku, Actinidia polygama, Ryukyuchiku, Ryukyu rose strawberry, apple immature fruit,

Persimmon leaf, licorice leaf, moon peach leaf, eucommia leaf extract, and equol, isoflavone, ifenpro

Jill, pearl protein hydrolyzate, catechol, caffeic acid, and prunin are LA 30

Anti-wrinkle action and anti-small dilosis by scorbic acid, derivatives of L-ascorbic acid, and their salts

Because it can effectively enhance the wa action, whitening action, anti-staining action, and anti-slacking action.

, Can be used as a more suitable combination in the present invention. In addition, the saccharification reaction

Among the plant extracts that have an inhibitory effect, plants of the family Cupressaceae (such as Thujopsis dorsalis) and plants of the family Ginkgoaceae

Things (Ginkgo, etc.), Rutaceae plants (Oubaku, Orange, Lemon, etc.), Labiatae plants

Things (perilla, rosemary, etc.), plants of the family Houttuynia cordata (Houttuynia cordata, etc.), and Eucommia ulmoides

Extracts of plants (such as Eucommia ulmoides) are preferably used. Among them, asunaro extract, ginkgo

Extract, Phellodendron amur extract, Orange extract, Perilla extract, Houttuynia cordata extract, and Eucommia ulmoides

Since the leaf extract also has an effect of improving skin turnover, in the present invention, L-

In combination with ascorbic acid, derivatives of L-ascorbic acid, and salts thereof 40

It can be used most preferably. Moreover, these plant extracts or plants having an inhibitory effect on saccharification reaction

Selects compounds from L-ascorbic acid, derivatives of L-ascorbic acid, and salts thereof.

Effectively produce advanced glycation end products (AGEs) when used in combination with one or more of these

Since it can be suppressed, the deposition of unwanted AGEs on the skin tissue can be reduced or suppressed.

In addition, in the process of producing AGEs, collagen is randomly cross-linked within and between molecules.

Is formed and reduces the cause of physical and physiological changes (denaturation) in collagen.

Is effective for skin aging such as wrinkles, rough skin, dullness, or reduction of elasticity.

It can be prevented or improved. Furthermore, a plant extract having a saccharification reaction inhibitory effect

One selected from L-ascorbic acid, derivatives of L-ascorbic acid, and salts thereof.

When used in combination with two or more species, the off-flavors and off-flavors caused by those plant extracts are masked. 50
 (17) JP 2018-90631 A 2018.6.14

At the same time, it has the advantage of significantly increasing storage stability.

0055

As a suitable blending amount of each of the plant extracts or compounds having a saccharification reaction inhibitory effect,

, In the external composition for skin of the present invention, or in a lotion, a cleanser, a beauty essence, a milky lotion, or a cream.

Select from L-ascorbic acid, derivatives of L-ascorbic acid, and salts thereof contained in

Usually, 0.0001 part by mass or more is preferable with respect to 1 part by mass of the total amount of one kind or two or more kinds.

0.001 to 50 parts by mass, more preferably 0.001 to 10 parts by mass, even more preferable.

Appropriately, it is blended in the range of 0.01 to 1 part by mass. If it is below the lower limit of the compounding amount, or

If the above upper limit of the blending amount is exceeded, the expected effect will be significantly reduced or will not be exhibited.

It is not preferable because there is. Ten

0056

In addition, the external composition for skin of the present invention is used to extract a plant having the effect of improving skin turnover.

A plant extract or compound having an inhibitory effect on the glycation reaction is usually used together with the substance or compound.

Approximately equal amounts, 0.01 to 1% by mass, L-ascorbic acid, L, per composition.

-A total amount of one or more selected from derivatives of ascorbic acid and salts thereof (none)

L-ascorbic acid as an active ingredient when 1 to 10% by mass is blended (in terms of water)

, L-ascorbic acid derivatives, and their salts have a high effect on improving skin turnover

In addition, the plant extract or compound having the effect of improving skin turnover and the above-mentioned

Combined with the action of plant extracts or compounds that have an inhibitory effect on the glycation reaction, the skin turns

Bar improving effect, anti-wrinkle effect, anti-fine wrinkle effect, whitening effect, anti-staining effect, anti-slacking effect 20

Can be significantly increased until the additive effect is exceeded.

[0057]

B. Basic cosmetics

The external composition for skin of the present invention is preferable in the field of cosmetics such as basic cosmetics and make-up cosmetics.

Suitable for use, especially for lotions, cleansers, serums, emulsions, which are applied directly to the skin,

Excellent anti-aging effect can be expected when blended in basic cosmetics such as cream.

To. The following describes typical basic cosmetics to which the external composition for skin of the present invention can be used.

I will reveal.

0058.

<Toner> 30

As described above, the external composition for skin of the present invention is based on an aqueous medium.

It can be made into a lotion by further adding ethanol and a moisturizer. make up

Water supplies water and moisturizing ingredients to the stratum corneum of the skin and helps the skin's physiology.

Used. Specifically, the lotion includes a cleansing lotion, an astringent lotion, and a soft makeup.

Water, multi-layer lotion, etc., skin lotion, body lotion, hand lotion, etc.

It also includes emollient lotion.

[0059]

(Moisturizer)

Examples of the moisturizer used in the lotion of the present invention include the following. That is, Guri

Serine, ethylene glycol, propylene glycol, 1,3-butylene glycol, 3 40

-Methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-

Propanediol, trimethylolpropane, pentaerythritol, diglycerin, po

Liglycerin, diethylene glycol, triethylene glycol, polyethylene glycol

, Dipropylene glycol, polypropylene glycol, 1,2-pentanediol,

1,2-hexanediol, 1,2-heptanediol, isoprene glycol, isope

Ntyldiol, hexylene glycol, triglycerin, 2-methacryloyloxye

Chill phosphoryl choline, tetrahydrofurfuryl alcohol, polyoxyethylene (PO)

E) Tetrahydrofurfuryl alcohol, polyoxypropylene (POP) butylate

Le, POP / POE butyl ether, tripolioxypropylene glycerin ether, P

OP glycerin ether, POP glycerin ether phosphoric acid, POP / POE pentaeri 50
 (18) JP 2018-90631 A 2018.6.14

Slitol ether, ethylene glycol / propylene glycol copolymer, phytant

Polyhydric alcohols such as riol and erythrulose, ethylene glycol monomethyla

Tel, Ethylene Glycol Monophenyl Ether, Ethylene Glycol Monohexyl A

Tel, diethylene glycol monomethyl ether, triethylene glycol monoethyle

Ether, monooleyl glycer ether, diethylene glycol monoethyl ether, d.

Tylene glycol monoethyl ether, ethylene glycol monobutyl ether, diete

Glycolalkyl ethers such as lenglycol dibutyl ether, sorbitol, key

Siritol, erythritol, mannitol, maltitol, maltitol, mal

Sugar alcohols such as totetritor, hydrogenated starch hydrolyzate, sucrose, la

Munose, glucose, fructose, galactose, mannose, threose, xyllo Ten

S, arabinose, fucose, ribose, deoxyribose, maltose, maltose

Aus, maltotetraose, trehalose, lactose, raffinose, gluconic acid,

Glucuronic acid, glucosyltrehalose, maltosyltrehalose, maltotriosylt

Carbohydrate derivatives of trehalose, such as rehalose and maltotetraosyltrehalose, sulfated

Trehalose, Dextrin, Cyclodextrin, International Publication No. WO 02/1036

Cyclo {→ 6) -α-D-glucopyranosyl- (1 → 3) disclosed in Pamphlet No. 1.

-Α-D-Glucopyranocil- (1 → 6) -α-D-Glucopyranocil- (1 → 3) -α

-D-Glucopyranosyl- (1 →} cyclic tetrasaccharide (cyclonigerosylnigero)

S: Cyclonigerosylnigerose), JP-A-2005-95148

Cyclo {→ 6) -α-D-glucopyranosyl- (1 → 4) -α-D-gu described in the publication. 20

Lucopyranosyl- (1 → 6) -α-D-glucopyranosyl- (1 → 4) -α-D-gluco

Cyclic tetrasaccharide having a pyranosyl- (1 →} structure (cyclomaltosyl maltose: Cycl)

Omaltosylmaltose), pullulan, high fructose corn syrup, xylityl glucoside, etc.

Sugars, valine, leucine, isoleucine, threonine, methionine, phenylalanine

, Tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine,

Cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, gu

Lutamic acid, monosodium glutamate, hydroxylysine, arginine, ornithine, hi

Amino acids such as stidine and pyrrolidone carboxylic acid, sodium lactate, uric acid, pyrrolidoneca

NMF components (natural moisturizing components) such as sodium rubonate, glycogen, dextran,

Locust bean gum, xyloglucan, quince seeds, carrageenan, pectin, ma 30

Nnan, curdlan, succinoglucan, galactan, arabinogalactan, dermatan

Sulfuric acid, keratan sulfate, chondroitin, chondroitin sulfate, mucoitin sulfate, keratosulfuric acid

Mucopolysaccharides such as acid, chitin, chitosan, heparin, heparan sulfate, hyaluronic acid and this

Lamucopolysaccharide hydrolyzate, soy protein-degrading peptide, wheat proteolytic peptide, hydrolyzed small

Acylated peptides such as wheat protein, casein-degrading peptides, palmitoyl oligopeptides,

Cyrilized peptides, conchiolin-degrading peptides, hydrolyzed conchiolin, silk and kora

Proteins / peptides such as gene and their hydrolysates, hydrolyzed hyaluronic acid, hydrolyzed

Water-soluble polymer substances such as eggshell membranes, salts of these, lecithin derived from soybeans, egg yolks, etc.

Osfatidylglycerol, phosphatidylinositol, phosphatidylserine

, Phosphatidylethanolamine, phosphatidic acid, sphingomyelin, etc. 40

Phospholipids, sphingolipids, olive oil, jojoba oil, oils and fats such as squalane, dimethyl

Silicones such as polysiloxane and methylphenylsiloxane, lactic acid bacteria and bifidobacteria

Which culture supernatant, royal jelly extract, yeast extract, eggshell membrane protein, submandibular gland mucin,

Hypotaurine, galactoarabinan, sesame lignan glycosides, albumin, whey, coli chloride

, Phosphorylcholine, placenta extract, yoquinin extract, button extract, seaweed extract, ge

Ntiana extract, Saxifraga stolon extract, Perilla extract, Hydrolyzed rice bran extract, Prune fermentation

Elementary decomposition products, trimethylglycine, N-methyl-L-serine, nicotinamide, Ogon

Extract, Cha extract, Centella asiatica extract, Kuwa extract, Alcaligenes-producing polysaccharide, Hakuga

Hydrolyzed Ishi, Sodium Acetyl Hyaluronate, Artea Extract, Angelica Acutiloba Extract

, Aloe extract, Izayoi rose extract, sodium deoxyribonucleic acid, merosria extract 50
 (19) JP 2018-90631 A 2018.6.14

, Carrot extract, Houttuynia cordata extract, Oolong tea extract, Wheat germ extract, Xylobio

Soot mixture, Phellodendron amur extract, Phellodendron amur extract, Hypericum extract, Cucumber extract,

Whey, Sakura leaf extract, Peony extract, Sanguisorba extract, Acerola extract, Hio

Ugi extract, Edelweiss extract, Almond extract, Glucosyl hesperidin, Ye

Low Himalayan Raspberry Root Extract, Peppermint Extract, Gio Extract, Mevalonora

Kuton, Angelica keiskei extract, Ginkgo biloba extract, Horsetail extract, Hydrolyzed black bean extract, Thyme

Extract, Coptis chinensis extract, adenosine monophosphate, adenosine triphosphate disodium, dl

-Α-tocopherol, DL-sodium malate, γ-amino-β-hydroxybutyric acid, a

Snaro extract, asparagus extract, asparagus linearis extract, avocado extract,

Apricot juice, mussel glycogen, innosit, ibukitranoo extract, nettle extract Ten

, Turmeric extract, Bearberry style extract, Agetsu extract, Echinashi leaf extract, Ethylglu

Cosid, Pride of India extract, Panax ginseng extract, Ononis extract, Olive

Leaf extract, oyster extract, gama extract, camu camu extract, camu camu seed extract, carrot

Kiss, raspberry extract, kiwi extract, guava extract, gardenia jasmine extract, kumazasa extract

, Clara extract, glycolic acid, grapefruit extract, clematis extract, chlore

La extract, cape aloe extract, geranium thunbergii extract, coffee extract, succinic acid 2-

(2-Hydroxyethoxy) ethyl guanidine, rice bran extract hydrolyzate, collagen

・ Tripeptide, choy sum extract, succinyl atelocollagen, hawthorn extract, sun

Pens extract, cyanocobalamin, sea glass extract, linden extract, dimethyl silano

Le hyaluronic acid condensate, Filipendula multijuga extract, Iris root extract, Birch extract, 20

Silk extract, silk powder, honeysuckle extract, star fruit leaf extract, strawberry fruit

Juice, ivy extract, hawthorn extract, sempukuka extract, senburieki

Su, Souhakuhi extract, sorbitol fermented polysaccharide solution, soybean extract, taiso extract, brim

Key extract, daisy extract, termina extract, tencha extract, tounin extract, to

Uhi extract, corn extract, tomato juice, nobara extract, hibiscus extract, ha

Prickly pear extract, Angoumois root extract, Lady's mantle extract, lotus seed lactic acid bacterium fermented liquid, pase

Re-extract, witch hazel extract, witch hazel extract, rose extract, paris etalia extract, bread

Kratium maritimum extract, blackberry extract, loquat leaf extract, phytoglycogen, bu

Thatcher Bloom Extract, Impatiens Extract, Sodium Polyaspartate Solution, Mayora

Na extract, lily extract, indigo water extract, horse chestnut extract, elastin, natural ceramide (ta) 30

Ipu 1, 2, 3, 4, 5, 6), hydroxyceramide, pseudoceramide, glycosphingolipid

, Ceramides such as ceramides and sugar ceramide-containing extracts, deep sea water, alkaline simple hot spring water

, Polyoxyethylene methyl glucoside, dl-sodium pyrrolidone carboxylate, L-

Oxyproline, acetylglucosamine, taurine and the like can be exemplified.

[0060]

In particular, in the case of a lotion containing the external composition for skin of the present invention, it has an excellent moisturizing effect and is L.

-Combined with one or more selected from ascorbic acid, its derivatives, and salts thereof

The following moisturizers that can more effectively improve rough skin by letting them

It is preferable to use it. That is, glycerin, ethylene glycol, propylene glycol

Lu, 1,3-butylene glycol, 3-methyl-1,3-butanediol, pentaeryth 40

Ritol, diglycerin, polyglycerin, diethylene glycol, triethylene glyco

, Polyethylene glycol, dipropylene glycol, trehalose, ceramides,

2-methacryloyloxyethyl phosphorylcholine, hyaluronic acid, chondroitin sulfate

, Hydrolyzed hyaluronic acid, yeast extract, yokuinin extract, button extract, seaweed extract,

Gentiana extract, trimethylglycine, N-methyl-L-serine, nicotinamide,

It is desirable to use one or more selected from royal jelly extract as a moisturizer.

I.

[0061]

Each of the moisturizers is usually 0.0001% by mass or more per mass of the lotion of the present invention.

Preferably, 0.001 to 50% by mass, more preferably 0.01 to 25% by mass, and further. 50
 (20) JP 2018-90631 A 2018.6.14

Preferably, it is blended in the range of 0.1 to 10% by mass.

[0062]

Further, the lotion of the present invention contains the astringents and keratin softeners described below according to its purpose and function.

Formulate one or more selected from agents, emollients (softeners) and surfactants

be able to.

[0063]

(Astringent)

Astringents include citric acid, tannic acid, acetoxypropionic acid, isovaleric acid, and a.

Mino valeric acid, ethoxyacetic acid, ethoxypropionic acid, isoaminovaleric acid, epoxy olei

Acid, elaidic acid, aminobutyric acid, erucic acid, oxaloacetate, formic acid, icosanoic acid, gluc Ten

Lonic acid, iduronic acid, crotonic acid, chloroisocrotonic acid, isocrotonic acid, acetic acid, dihi

Drolipoic acid, tartaric acid, ethyl crotonic acid, diphenylacetic acid, dimethoxyphthalic acid, ethyl

Hydroxybutyric acid, succinamide acid, stearic acid, stearolic acid, sorbic acid, Tigli

Acid, thyroxine, decanoic acid, tropic acid, lactic acid, hydroxyisobutyric acid, hydroxyvaleric acid

, Pyruvic acid, butyl acetic acid, butyl hydroperoxide, brassic acid, propiolic acid,

Pyropionic acid, bromoisovaleric acid, bromoisobutyric acid, bromopropionic acid, caproic acid,

Hexenoic acid, petroselinic acid, heptadecanoic acid, heptanic acid, areanilic acid, maleamide

Acid, mycolic acid, myristic acid, methacrylic acid, methyl valeric acid, methyl thioacetic acid, methyl

Butyric acid, mevalonic acid, melissic acid, mercaptoacetic acid, iodoacetic acid, lauric acid, ricinerai

Dinic acid, ricinoleic acid, linoleic acid, linolenic acid, aconitic acid, oxalosuccinic acid, o 20

Xoglutaric acid, adipic acid, calcein, carboxyphenylacetic acid, acetoxyamber

Acid, carboxycomeronic acid, canphoronic acid, isocanphoronic acid, glutaconic acid, glutal

Acid, isocitric acid, crocetin, succinic acid, phthalic acid, fumaric acid, isocincomeronic acid,

Diethylenetriamine pentaacetic acid, isophthalic acid, citramalate, dinicotinic acid, itaconic acid

, Dibromosuccinic acid, dichlorosuccinic acid, ethylmalonic acid, dimethylsuccinic acid, oxalic acid

, Cincomeronic acid, hemimeric acid, pelargonic acid, berberonic acid, benzenehexacarbo

Acid, benzenepentacarboxylic acid, maleic acid, malonic acid, mesaconic acid, mesotartaric acid, me

Soshu acid, methyl isophthalic acid, methyl succinic acid, methylmalonic acid, mercapto amber

Acid, melophanoic acid, peroxyphthalic acid, malic acid, lutidine acid, leukotriene bromo

Anthranilic acid, aminocinnamic acid, isopropylcinnamic acid, oxanic acid, arecaidine 30

, Carboxycinnamic acid, cinnamic acid, galloyl gallic acid, tranexamic acid, nitrocinnamic acid

, Hydroxycinnamic acid, methoxycinnamic acid, hydroxyhydrocinnamic acid, phenylcinnamic acid

Acid, ellagic acid, orotic acid, camphoric acid, quinic acid, hydroxyproline, etiocholane acid

, Caulmooglucic acid, carnosine, carbazole acetic acid, quinoline carboxylic acid, quinolinic acid

, Quinoline dicarboxylic acid, Coumalic acid, Chlorophenoxyacetic acid, Chenodeoxycholic acid,

Colanic acid, cholic acid, santonic acid, dihydroortho acid, succininal acid, thiophenica

Lubonic acid, tetrahydrofolic acid, dehydrocholic acid, terpenic acid, hydroxypyronecal

Bonic acid, hydroxypyrone dicarboxylic acid, hydroxyphenyl acetic acid, hydroxyphenyl

Propionic acid, biphenyldicarboxylic acid, homogentic acid, mandelic acid, muricholic acid

, Methyldopa, Methylphenylacetate, Methylfurancarboxylic acid, Methylred, Mefe 40

Namic acid, lysergic acid, lithocholic acid, lipoic acid, reserpine acid, retinoic acid, levopimal

Acid, glycolic acid, salicylate, zinc paraphenol sulfonate, altea, arnica,

Bistorta officinalis, Iris, Fennel, Pride of India, Orange, Rubus, Gua

Ba, Kurofusasuri, Geranium thunbergii, Hawthorn, Filipendula multijuga, Peony, Birch

, Honeysuckle, horsetail, ivy, thyme, tea, parsley, witch hazel, grapes,

Cornflower, Lemon, Astragalus sinensis, Sanguisorba officinalis, Kina, Salvia, Bodaiju, Otane

Carrots, Tosho, Mannenrou, Hypericum, Ginkgo, Melissa, Restharrows, Ma

Ronnier, Swertia japonica, garlic, chamomile, sim, mint, nettle, capsicum, sho

Uga, hops, horse chestnut, lavender, carrot, mustard, kei, pine, senkyu

U, elder, ostericum sieboldii, scopolia japonica, button, bayberry, dokudami, kohone, shibu 50
 (twenty one) JP 2018-90631 A 2018.6.14

Glehnia, Calendula officinalis, Glehnia, Glehnia, Daidai, Yuzu, Sho

Ubu, Natsumikan, Merry Rohto, Japanese pepper, Eucalyptus, Mugwort, Enmeisou, Rice

, Clara, ginger, cloves, walnut leaves, ginger, sage, rosemary, what

Houttuynia cordata, Coptis chinensis, Phellodendron amur, Houttuynia cordata, Heavy medicine, Chenpi, Carrot, Toushin, Taxia, Tannin, Birch tar

Plant extracts such as le, propolis, royal jelly, kobo extract, tuberospo

Lysaclide solution, oolong tea, alum, zinc chloride, zinc sulfate, aluminum sulfate,

Aluminum chloride, allantoin chlorohydroxyaluminum, allantoin dihydro

Xi-aluminum, chlorohydroxyaluminum, zinc oxide, zinc sulfide, sulfocoal acid

Organic composite salts of zinc, sulfophenolic acid, aluminum, zirconium, etc.

Is done. Ten

[0064]

Each of the astringents is usually 0.0001% by mass or more per mass of the lotion of the present invention.

, Preferably 0.001 to 50% by mass, more preferably 0.01 to 25% by mass, further.

Is preferably blended in the range of 0.1 to 10% by mass.

[0065]

In particular, in the case of a lotion containing the external composition for skin of the present invention, the astringent effect is excellent.

, Citric acid, succinic acid, tartaric acid, retinoic acid, malic acid and other acid agents, retinol, chloride

Zinc, aluminum powder, aluminum compounds such as aluminum sulphate, alum and variants

Sex alcohol, ethanol, Artea extract, Arnica extract, Bistorta officinalis extract,

Nettle extract, iris root extract, fennel extract, oolong tea extract, ethanol 20

, Pride of India salsbury extract, Hypericum extract, orange flower water, orange juice

, Capillary wormwood extract, raspberry extract, guava extract, black sardine fruit extract, ge

Laniol, Geranium thunbergii extract, Hawthorn extract, Filipendula multijuga extract, Peony

Extract, birch extract, honeysuckle extract, horsetail extract, ivy extract, se

Hawthorn extract, thyme extract, cha extract, Houttuynia cordata extract, parsley extract, ha

Mamelis extract, grape leaf extract, pine extract, Melissa extract, cornflower extract,

One selected from mugwort extract, lemon juice, astragalus extract, sanguisorba extract or

It is desirable to use two or more astringents.

[0066]

(Keratin softener) 30

Examples of keratin softeners include ethanol, isopropyl alcohol, propanol, and butano.

Le, polyethylene glycol, benzyl alcohol, phenylethyl alcohol, carbonated

Lopyrene, hexyldodecanol, dimethyl sulfoxide, dimethylacetamide, dime

Chillformamide, triethanolamine, diisopropyladipate, ethyllaurire

Toe, lanolin, fatty acid dialchirolamide, urea, sulfur, resorcin, phytic acid

, Lactic acid, lactate, glycolic acid, sodium hydroxide, potassium hydroxide and the like.

In particular, in the case of a lotion containing the anti-aging external composition of the present invention, horns

Urea, sulfur, ethanol, lactic acid, glycolic acid, salicylic acid, sulfur, which have excellent softening effect

It is desirable to use one or more selected from sodium acid and the like.

[0067] 40

(Emollient)

As an emollient (softener), an oily component that is close to sebum is desirable, and an oily component

Examples include hemp seed oil, astropotassium murmur fat, rape seed oil, and afuri.

Camelina oil, camelina seed oil, Argania spinosa oil, apricot oil, Umicro

Ilex serrata oil, etium plantagineum seed oil, emu oil, orange roughy oil, mosquito

Nora oil, Kaya seed oil, Kokum indica seed oil, Caraway seed oil, Apricot kernel oil

, Kukui nut oil, Cranbear vinyl seed oil, Cranberry seed oil, Walnut seed oil, Ku

Lingonberry seed oil, cowberry seed oil, rice germ oil, goyomatsu seed oil, southern ka oil, sa

Lasouju seed fat, oxidized corn oil, shea butter oil, Shoreastenoptera fat, Shirobana loopi

Seed oil, hydrogenated avocado oil, hydrogenated olive oil, hydrogenated beef tallow, hydrogenated soybean oil, hydrogenated rapeseed seeds 50
 (twenty two) JP 2018-90631 A 2018.6.14

Oil, hydrogenated milk fat, hydrogenated palm kernel oil, hydrogenated palm oil, hydrogenated castor oil, hydrogenated jojoba oil, hydrogenated vegetables

Oil, hydrogenated coconut oil, sclerocaria birea oil, ostrich oil, passionflower seed oil, cha

Real oil, camellia oil, turkey peach seed oil, theobroma grandiflorum seed oil, lard, milk fat

, Coix seed oil, babassu oil, peanut oil, pistacio seed oil, hypofaerum noides oil

, Sunflower seed oil, bilberry seed oil, grape seed oil, partially hydrogenated perilla oil, partially hydrogenated horse oil

, Prune seed oil, broccoli seed oil, loofah seed oil, pumpkin seed oil, tomatoco

Casspurbialis oil, cloudberry seed oil, pine seed oil, mango seed fat, mango

Seed oil, mink oil, melia azalea lacta seed oil, peach kernel oil, vegetable oil, camellia oil, European

Paki strawberry seed oil, apple seed oil, borage seed oil, rosehip oil, wasabi tree seed oil

, Macademia nut oil, castor oil, olive oil, almond oil, cacao oil, camellia oil, coconut oil Ten

, Palm oil, wood wax, jojoba oil, grape seed oil, avocado oil, safflower oil, sesame oil

, Tea oil, evening primrose oil, wheat germ oil, hazelnut oil, meadowfoam oil, persic oil,

Hakka oil, tea tree oil, corn oil, rapeseed oil, sunflower oil, flaxseed oil, cottonseed oil

, Soybean oil, peanut oil, rice bran oil, cacao butter, shea butter, fennel oil, perilla oil, chamomile

Oil, carrot oil, cucumber oil, egg yolk oil, beef tallow, horse fat, fish oil, turtle oil, orange

Vegetable oils and fats such as raffy oil or animal oils and fats, poison ivy peel wax, jasminum grandiflorum flower wax,

Orange peel wax, orange flower wax, hydrolyzed jojoba ester, carnauba wax, can

Delilah wax, daffodil flower wax, rice bran wax, southern wax myrtle fruit wax, sweet

Acacia flower wax, tuberose flower wax, beeswax, whale wax, orange raffy oil,

Waxes such as lanolin, rice wax, montan wax, ozokerite, isoeiko 20

San, isododecane, isohexadecane, diethylhexylcyclohexane, pentahide

Squalene, mineral oil, liquid paraffin, polyisobutene, hydrogenated polyisobutene

, Polybutene, Squalane, Squalene, Microcrystalline Wax, Celesinwat

Kusu, paraffin wax, petrolatum, ozokerite, α-olefin oligomer, tet

Hydrocarbons such as ladecene, isomerized linoleic acid, beef tallow fatty acid, fatty acid (C14-28),

Fatty acid (C20-40), hydrogenated coconut fatty acid, palm kernel fatty acid, 10-hydroxydecanoic acid

, Branched fatty acid (C14-28), branched fatty acid (C12-31), behonic acid, capric acid,

Myristic acid, palmitic acid, stearic acid, behenic acid, lanolin fatty acid, linoleic acid

, Linolenic acid, lauric acid, oleic acid, isostearic acid, undecylenic acid, 1,2-

Hydroxystearic acid, palmitooleic acid, erucic acid, docosahexaenoic acid, Eiko 30

Sapentaenoic acid, isohexadecane acid, anteisohenicosanoic acid, isononanoic acid, 2-

Natural and synthetic fatty acids such as ethylcaproic acid and salts thereof, (C12-16)

Alcohol, (C14-22) alcohol, (C20-22) alcohol, (C20-4)

0) Alcohol, (C30-50) Alcohol, Brassica seed sterols, Isocetyla

Lucor, isopropanol, caprylyl glycol, rice casterol, hydrogenated rapeseed

Oil alcohol, cetanol, stearyl alcohol, hexyldecanol, octyldode

Canol, lauryl alcohol, caprylic alcohol, myristyl alcohol, oleyl

Alcohol, cetostearyl alcohol, arachidyl alcohol, behenyl alcohol, e

Hova alcohol, Kimil alcohol, Ceraquil alcohol, Bacil alcohol, Isoste

Allyl alcohol, cetyl alcohol, cholesterol, phytosterols, lanolina 40

Lucor, hydrogenated lanolin alcohol, palmityl alcohol, 2-decyltetradecino

Natural and synthetic higher alcohols such as (C12-15) Palace-9 Carboxylic Acid Isop

Lopil, octyldodecyl pyrrolidone carboxylate, menthyl pyrrolidone carboxylate, pyro

Lauryl lydone carboxylate, cetyl PEG-2 isodeces-7 carboxylate, diadipate

PPG-3 myristyl, di-PPG-2 milles-10 adipate, diisopropi adipate

Lu, diheptyl undesyl adipate, ethyl avocado fatty acid, butyl avocado oil fatty acid

, Methyl Gluces-20 Benzoate, Ethyl Isostearate, (Isostearic Acid / Koha

Castor oil) Castor oil, hydrogenated castor oil isostearate, batyl isostearate, isostair

Hexyldecyl phosphate, (isostearic acid / beeswax / succinic acid) castor oil, isonona

Isodecyl acidate, Isotridecyl isononanoate, Isononyl isononanoate, Isononanoic acid 50

 (twenty three) JP 2018-90631 A 2018.6.14

Octyl, cetearyl isononanoate, sucrose isobutyrate, caprylyl eicosenoate

, Butyl ethylhexanoate, Ethylpropanediol, Octyldodecyl erucate, Elca

Oleyl acid, alkyl octanoate (C14,16,18), (octanoic acid / stearic acid)

/ Adipic acid) Glyceryl, cetyl octanate, cetearyl octanate, heki octanate

Syldecyl, olive fatty acid ethyl, oleyl oleate, (capryl / capric acid)

Lyceriz, (capril / caprin / palm fatty acid) glyceryl, (caprylic acid / capric acid)

/ Succinic acid) Triglyceryl, cetyl caprate, triisostearyl citrate, citrate

Triisooctyldodecyl acid, (citric acid / lactic acid / linoleic acid / oleic acid) glyceryl

, Isostearyl diglyceryl succinate, diethoxyethyl succinate, diocty succinate

Le, rice bran oil fatty acid phytosteryl, cetyl acetate, farnesyl acetate, lanolina acetate Ten

Lucor, linalyl acetate, propylene glycol diisostearate, diisosteare

Acid dimer dilinoleil, neopentyl glycol diisostearate, diethyl hexa

Neopentyl glycol neate, PEG-18 castor oil dioleate, di (caprylic acid)

(Prinic acid) Butylene glycol, dicapric acid isosorbide, di (caprylic acid / capri)

Acid) Polyethylene glycol, distearyl citrate dicocoyl pentaerythrityl,

Polyethylene glycol distearate, PG-20 methyl glucose distearate,

Pentaerythrityl distearate, diethylpentanediol dineopentane, dine

Methylpentanediol opentanate, polyethylene glycol dinonanoate, fatty acid (C

10-30) (cholesteryl / lanosteryl), fatty acid (C12-18) cetyl, dilau

Glycol phosphate, diisopropyl dilinoleate, hydrogenated pentaerythrityl rosinate, water 20

Methyl syrup, (hydrogenated rosin / diisostearic acid) glyceryl, ethistearate

Luhexyl, stearoyloxystearate isosetyl, stearoyloxysteari

Octildodecyl acid acid, dibutyl octyl sebacate, octyldo dimer linoleate

Decyl / PPG-3 myristyl ether, dimer dilinoleate di (isostearyl / fu)

Itofitril), disetearyl dimerdilinoleic acid, hydrogenated castor linoleic acid

Si oil, stearyl dimer dilinoleate / PPG-3 myristyl ether, dimer dily

Dimer dilinoleyl linoleic acid, dimer dilinoleyl bis (behe)

Nyl / isostearyl / phytophytosteryl), dimer dilinoleic acid (phytophyto)

Stearyl / isostearyl / cetyl / stearyl / behenyl), dimer dilinoleyl water

Condensation of rosin, dialkyl carbonate (C14,15), diethylhexyl carbonate, dicap 30

Lilyl, pentaerythrityl tetraisostearate, pentaerythri tetraoctanoate

Chill, dodeca (caprylic acid / capric acid) polyglyceryl-10, dodecanedioic acid diisose

Chill, dioctyl dodecyl dodecane, triisostea, triethylcaproate

Lisrityl, ditrimethylolpropane triethylhexanoate, trioctanoin, tri

Trimethylolpropane octanate, tricaprylin, tri (caprylic acid / capric acid)

Glyceryl, tri (caprylic acid / capric acid / stearic acid) Glyceryl, tri (caprylic acid)

Acid / capric acid / myristic acid / stearic acid) Glyceryl, trifatty acid (C8-12)

) Glyceride, tristearin, tripalmitin, tripalmitin, trihydroxy

Stearin, tribehenin, dipentaerythrityl tripolyhydroxystearate, to

Limyristin, alkyl lactate (C12-15), ethyl lactate, octyldodecyl lactate, milk 40

Butyl acid, menthyl lactate, isodecyl neopentane, myristyl neopentane, nona

Octyl acidate, cholesteryl nonanoate, ethylhexyl palmitate, ceti palmitate

Le, bisdiglyceryl polyacyl adipate-1, bisdiglyceryl polyacyl adipate

To-2, (hydroxystearic acid / isostearic acid) dipentaerythrityl, hydro

Ethylhexyl xystearate, octyl hydroxystearate, hydroxysteer

Phosphoric acid hydrogenated castor oil, (hydroxystearic acid / stearic acid / rosin acid) dipentae

Lisrityl, phytosteryl hydroxystearate, castor fatty acid PPG-5.5, castor

Methyl maci fatty acid, myristyl propionate, branched fatty acid (C12-31) cholesteryl

, Dipentaerythrityl hexahydroxystearate, Hexa (Hydroxystearia)

Acid / stearic acid / rosinic acid) dipentaerythrityl, stearyl heptanate, (behen 50

 (twenty four) JP 2018-90631 A 2018.6.14

Acid / icosane diacid) glyceryl, jojoba ester, jojoba fatty acid isopropyl, macade

Mia nut fatty acid ethyl, macadamia nut fatty acid cholesteryl, macadamia nut fat

Phytosteryl acid, dioctyl maleate, diethylhexylsilingylidene malonate,

Hexyldecyl myristoylation methylaminopropionate, citronellyl methylcrotonate

, Meadowfoam estride, Meadowfoam oil fatty acid octyldodecyl, (coconut oil fat

Acid / citric acid / lactic acid) glyceryl, coconut oil fatty acid decyl, cholesteryl butyrate, dihydrobutyrate

Locholesteryl, lanolin fatty acid octyldodecyl, lanolin fatty acid cholesteryl, Rishi

Octyldodecyl noreate, diethylhexyl malate, trioleyl phosphate, phosphoric acid

Tricetyl, glyceryl tri2-ethylhexanoate, cetyl 2-ethylhexanoate, di2

-Neopentyl glycol ethylcaproate, isopropyl myristate, myristic acid Ten

Butyl, isopropyl palmitate, ethyl stearate, octyl palmitate, iso

Isocetyl stearate, butyl stearate, ethyl linoleate, isopro linoleate

Pills, ethyl oleate, isosetyl myristate, isostearyl myristate, pal

Isostearyl mitate, octyldodecyl myristate, diethyl sebacate, dipine

Diisopropyl acid, isoaraquil neopentanoate, tri (capryl capric acid) glyce

Lil, tri2-ethylhexanoic acid trimethylolpropane, triisostearate trime

Tyrolean propane, pentaerythritol tetra2-ethylhexanoate, ceticaprylate

Lu, decyl laurate, hexyl laurate, decyl myristate, myrith myristate

Chill, cetyl myristate, glycerin trimyristin, stearyl stearate, o

Re 20

Decyl inate, cetyl ricinoleate, isostearyl laurate, isoto myristate

Redesyl, isosetyl palmitate, octyl stearate, isosetil stearate,

Isodecyl oleate, octyldodecyl oleate, octyldodecyl linoleate, i

Isopropyl sostearate, cetostearyl 2-ethylhexanoate, 2-ethylhexa

Stearyl acid acid, hexyl isostearate, ethylene glycol dioctanoate, diole

Ethylene glycol inate, propylene glycol dioleate, propylene dicaprate

Nglycol, di (caprylic capric acid) propylene glycol, tri (caprylic acid)

Prinic acid) Glycerin, propylene glycol dicaprylate, neopentyl dicaprate

Glycol, neopentyl glycol dioctanoate, glyceryl tricaprylate, triu

Glyceryl ndecylate, Glyceryl triisopalmitate, Glyceyl triisostearate 30

Lil, octyldodecyl neopentane, isostearyl octanoate, heki neodecanoate

Syldecyl, octyldodecanoic acid, isostearyl isostearate, isos

Octyldecyl tearate, polyglycerin oleate, polyglycerin isos

Tearic acid ester, dipropyl carbonate, dialkyl carbonate (C12-18), tricitrate

Isocetyl, triisoaraquil citrate, triisooctyl citrate, lauryl lactate, milk

Myristyl acid, cetyl lactate, octyldecyl lactate, lanolin lactate, triethyl citrate,

Acetyl Triethyl Citrate, Acetyl Tributyl Citrate, Trioctyl Citrate, Li

Diisostearyl ngoate, 2-ethylhexyl hydroxystearate, di2-succinate

Ethylhexyl, diisobutyl adipate, diisopropyl sebacate, geosebacate

Cutil, cholesteryl stearate, cholesteryl isostearate, hydroxysteer 40

Cholesteryl Phosphate, Cholesteryl Oleate, Dihydrocholesteryl Oleate, Iso

Phytosteryl stearate, phytosteryl oleate, 12-stearoylhydroki

Isocetyl cysteate, stearyl 12-stearoyl hydroxystearate, 1

2-Stearoyl hydroxyisostearyl stearate, hexyl dimethyl octanate

Esters such as decyl and lanolin fatty acid isopropyl, liquid lanolin, reduced lanolin,

Adsorption-purified lanolin, lanolin acetate, liquid lanolin acetate, hydroxylanolin, polyoxy

Lanolin such as ethylene lanolin, hard lanolin fatty acid, acetic acid (cetyl lanolin) ester

, Lecithin, phosphatidylcholine, phosphatidylethanolamine, phosphatidyl

Zyrserine, phosphatidylglycerol, phosphatidylinositol, sphingomi

Sphingolipids such as erin, phospholipids such as phosphatidic acid and lysolecithin, hydrogen 50
 (twenty five) JP 2018-90631 A 2018.6.14

Additive soybean phospholipids, partially hydrogenated soybean phospholipids, hydrogenated egg yolk phospholipids, partially hydrogenated eggs

Phospholipid derivatives such as yellow phospholipids, dihydrocholesterol, lanosterol, dihydro

Lanosterol, sterols such as cholic acid, methylphenylpolysiloxane, methylha

Idrogene polysiloxane, octamethylcyclotetrasiloxane, stearoxysiri

Corn, decamethylcyclopentasiloxane, tetramethyltetrahydrogencyclo

Silicone oils such as tetrasiloxane and dodecamethylcyclohexanesiloxane, support

Genins, saponins, perfluoropolyether, perfluorodecalin, perfluo

Fluorine-based oils such as rooctane can be exemplified.

[0068]

In particular, in the case of a lotion containing the external composition for skin of the present invention, it has an emollient effect. Ten

Excellent and widely used in the cosmetics field, cetanol, lauryl alcohol, cetostearyl

Alcohol, stearyl alcohol, oleyl alcohol, behenyl alcohol, lanoli

Alcohol, hydrogenated lanolin alcohol, hexyldecanol and octyldodecanol

, Squalene, vegetable squalane, cetyl 2-ethylhexanoate, α-olefin oligo

Ma, isotridecyl isononanoate, isononyl isononanoate, cetearyl isononanoate

, Ethyl oleate, oleyl oleate, ethylhexyl palmitate, caprilrug

Assemble one or more emollients selected from recall and hydrogenated soybean phospholipids

It is desirable to use it together.

[0069]

(Surfactant) 20

Surfactants include sorbitan monolaurate, sorbitan coconut oil fatty acid, and distea.

Sorbitan phosphate, sorbitan monostearate, sorbitan tristearate, monoi

Sorbitan sostearate, sorbitan monooleate, sorbitan trioleate, so

Rubitan fatty acid ester, sorbitan monopalmitate, sorbitan sesquioleate,

Sorbitan sesquistearate, polyoxyethylene sorbitan monolaurate, mono grande

Polyoxetylene sorbitan tearate, ethylene glycol monostearate, diste

Ethylene glycol anate, diethylene glycol distearate, ethylene glycol

Lu fatty acid ester, monostearic acid glyceride, glyceryl distearate, isoste

Glyceryl Aliate, Polyoxyethylene Glyceryl Isostearate, Triisosteer

Polyoxyethylene glyceryl phosphate, diglyceryl isostearate, diisosteari 30

Glyceryl acid, glyceryl triisostearate, diglyceryl triisostearate

, Propylene glycol monostearate, Self-emulsifying propylene glycol stearate

Lu, glyceryl ricinoleate, propylene glycol ricinoleate, propylene glycol

Cole fatty acid ester, propylene glycol dioleate, propylene glycol laurate

Cole, glyceryl linoleate, glyceryl diisopalmitate, glyceryl sesquioleate

Ceryl, glyceryl monooleate, glycerin trimyristin, lanolin fatty acid iso

Propyl, hexyldecyl dimethyloctanoate, acetoglyceryl, triisooctanoic acid

Glyceryl, di2-heptyl undecanerate glyceryl, pyroglutamic acid oleate Gly

Ceryl, decaglyceryl decaoleate, dipentaerythlit fatty acid ester, steer

Glyceryl malate phosphate, polyoxyethylene laurate hardened castor oil, polyoxye 40

Tylenealkyl (12-14) ether (7EO), polyoxyethylene alkyl (

12-14) Ether (12EO.) Polyoxyethylene alkyl ether (20E.O.).

O. ), Polyoxyethylene lauryl ether, Polyoxyethylene myristyl ether

, Polyoxyethylene cetyl ether, polyoxyethylene cetostearyl ether, po

Lioxyethyl stearyl ether, polyoxyethylene oleyl ether, polyoxy

Ethylene oleyl cetyl ether, polyoxyethylene behenyl ether, polyoxye

Tylene octyl phenyl ether, polyoxyethylene nonyl phenyl ether, polio

Xyethylenealkyl (12,13) ether (10EO), polyoxyethyleneo

Cutyl dodecyl ether, polyoxyethylene cetylstearyldiether, sesquiste

Polyoxyethylylene methyl glucoside anate, carboxylated polyoxyethylene 50

 (26) JP 2018-90631 A 2018.6.14

Redesyl ether, polyethylene glycol octanoate (4) Polyoxyethylene nonyl

Phenyl ether (14EO) mixture, polyoxyethylene lanolin alcohol, po

Lioxyethylene (5) lanolin alcohol, polyoxyethylene (10) lanolin al

Cole, polyoxyethylene (15) lanolin alcohol, polyoxyethylene (20)

Lanolin alcohol, polyoxyethylene (25) Lanolin alcohol, polyoxyethi

Ren (40) lanolin alcohol, polyoxyethylene (alkylol lanolin arco)

R) Ether (16EO), polyoxyethylene lanolin alcohol acetate, polio

Xyethylene lanolin, polyoxyethylene / reduced lanolin, polyoxyethylene solbi

Thor lanolin (40EO), polyoxyethylene polyoxypropylene reduced lanolin

, Polyoxyethylene polyoxypropylene lanolin, polyoxyethylene polyoxy Ten

Propylene liquid lanolin, polyoxyethylene stearic acid amide, polyoxyethylene

Phytosterol, polyoxyethylene dinonyl phenyl ether, poly monolaurate

Ethylene glycol, polyethylene glycol dilaurate, polyethylene palmate

Recall, polyethylene glycol dipalmitate, polyethylene glycol dipalmitate

Or, polyethylene glycol monooleate, polyethylene glycol dioleate 1

50, Polyethylene glycol monostearate, Polyethylene glycol disstearate

Le, polyoxyethylene glyceryl tristearate, lanolin fatty acid polyethylene grease

Cole 300, lanolin fatty acid polyethylene glycol 600, lanolin fatty acid polyethi

Lenglycol 1000, polypropylene glycol monooleate (36), monolau

Polyoxyethylene sorbitan phosphate (20EO), polyoxyethylene coconut oil fat 20

Sorbitan acid (20EO), polyoxyethylene sorbitan monopalmitate (20)

O. E. ), Polyoxyethylene sorbitol oleate (40EO), monooleine

Polyoxyethylene sorbitan acid (6EO), polyoxyethylene monooleate

Rubitan (20EO), polyoxyethylene sorbitol monolaurate, tetraole

Polyoxyethylene sorbitate, polyoxyethylene sorbitan trioleate (

20E. O. ), Polyoxyethylene sorbitan monostearate (6EO), mono

Polyoxyethylene sorbitan stearate (20EO), polio tristearate

Xyethylene sorbitan (6EO), polyoxyethylene sorbihexastearate

T, polyoxyethylene sorbitol isostearate (3EO), monostearin

Polyoxyethylene glyceryl acid, polyoxyethylene sorbitol beeswax, polyoxy 30

Ethylene polyoxypropylene butyl ether, polyoxyethylene (20) polyoxy

Propylene (15) butyl ether, polyoxyethylene (35) polyoxypropylene

(28) Butyl ether, polyoxyethylene (36) polyoxypropylene (36)

Chill ether, polyoxyethylene (37) polyoxypropylene (38) butylate

Le, polyoxyethylene polyoxypropylene cetyl ether, polyoxyethylene poly

Oxypropylene decyl tetradecyl ether, polyoxyethylene polyoxypropylene

Oligosuccinate (3EO) (20PO), polyoxyethylene polyoxy

Propylene hexylene glycol ether (300EO) (75PO), tri (

Polyoxyethylene isostearic acid) Trimethylolpropane (3EO), polio

Glyceryl oxyethylene oleate, polyoxyethylene (10) polyoxypropylene 40

Glycol (30), Polyoxyethylene (16) Polyoxypropylene glycol (3)

0), polyoxyethylene (25) polyoxypropylene glycol (30), polyoki

Siethylene (160) polyoxypropylene glycol (30), polyoxyethylene (

30) Polyoxypropylene glycol (35), polyoxyethylene (200) polio

Xypropylene glycol (40), polyoxyethylene (200) polyoxypropylene

Diol (70), polyoxyethylene (20) polyoxypropylene glycol (

15) Butyl ether, polyoxyethylene (6) polyoxypropylene glycol (3)

0), polyoxyethylene (1) polyoxypropylene (4) cetyl ether, polyoki

Siethylene (1) Polyoxypropylene (8) Cetyl ether, Polyoxyethylene (2)

0) Polyoxypropylene (4) cetyl ether, polyoxyethylene (20) polyoki 50

 (27) JP 2018-90631 A 2018.6.14

Sipropylene (8) cetyl ether, polyoxypropylene (9) diglyceryl ether

, Polyoxypropylene stearyl ether, ethylenediamine tetrapolyoxyethile

Polyoxypropylene, polyoxyethylene (6EO.) Capryl / Glycaprate

Serine, polyoxyethylene glyceryl laurate, coconut oil fatty acid polyoxyethylene

Lyceryl, polyoxyethylene diethanolamine lauric acid ester (4EO),

Dioctyldodecyl lauroyl glutamate, dipolyoxyethi lauroyl glutamate

Renstearyl Ether Diester, Lauroyl Glutamic Acid Polyoxyethylene Octi

Ludodecyl ether diester, pyroglutamic acid polyoxyethylene isostearate

Glyceryl, Pyroglutamic Acid Isostearate Polyoxyethylene Hardened Castor Oil, Cap

Phosphate diethanolamide, undecylenic acid monoethanolamide, coconut oil fatty acid monoe Ten

Tanol amide, coconut oil fatty acid diethanolamide (1: 2 type), coconut oil fatty acid dietano

Luamide, lauric acid ethanolamide, lauric acid diethanolamide, lauric acid

Isopropanolamide, myristic lauric acid diethanolamide, millilauric acid

Triethanolamine stinate, diethanolamide myristic acid, ethano palmitic acid

Luamide, monoethanolamide stearate, diethanolamide stearate, su

Tealic acid diethylaminoethylamide, isostearic acid diethanolamide, olei

Acid diethanolamide, linoleic acid diethanolamide, beef tallow fatty acid monoethanolamine

Mid, beef tallow fatty acid diethanolamide, hardened beef tallow fatty acid diethanolamide, lanolin fat

Fatty acid diethanolamide, polyoxyethylene coconut oil fatty acid amide (5EO), poly

Oxyethylene (2) coconut oil fatty acid monoethanolamide, polyoxyethylene (5) ya 20

Si oil fatty acid monoethanolamide, polyoxyethylene (10) coconut oil fatty acid monoethano

Luamide, polyoxyethylene coconut oil fatty acid diethanolamide, polyoxyethylene

Beef tallow alkyl diethanolamine (2EO), polyoxyethylene coconut oil alkyl di

Methylamine oxide, coconut oil alkyldimethylamine oxide solution, stearyl dimethi

Luamine oxide, oleyldimethylamine oxide, dihydroxyethyllaurylami

Noxide solution, pentaerythlit rosinate, hexaglyceryl oleate, sesquiste

Methyl glucoside anate, polyethylene glycol monooleate, polyethylene glyco

Alchol ethoxylate, polyoxyethylene alkyl ether, polyglycol diether,

Lauroyl diethanol amide, fatty acid isopropanol amide, maltitol hide

Loxy fatty acid ether, alkylated polysaccharide, alkyl glucoside, monomyristate trehalose 30

Trehalose such as loin, trehalose monoisostearate, trehalose monoundecylenate, etc.

Rehalose monofatty acid esters, polyoxyethylene dioleate methyl glucoside (

120E. O. ), Sugar es such as sucrose fatty acid ester, coconut oil fatty acid glyceryl

Tel, oil-based glycerin monostearate, self-emulsifying glycerin monostearate, po

Liglycerin monostearate, polyglycerin alkylate, sorbitan monooleate

, Polyethylene glycol monostearate, Polyoxyethylene sorbitan monooleate

G, polyoxyethylene sterols, polyoxyethylene lanolin, polyoxyethi

Lene wax, polyoxyethylene hydrogenated castor oil, glycerin fatty acid ester, polyglyceride

Serine fatty acid ester, POE sorbitol fatty acid ester, POE sorbitol fatty acid S

Tel, POE glycerin fatty acid ester, POE alkyl ether, POE fatty acid esthetic 40

Le, POE hardened castor oil, POE castor oil, POE / POP copolymer, POE / POP a

Lucil ether, polyether-modified silicone lauric acid alkanolamide, alkyl

Amine oxide, hydrogenated soy phospholipids, caprylyl glucoside, citric acid fatty acid glyce

Lil, glyceryl citrate stearate, corn oil PEG-8 esters, cocamide DE

A, cocamide MEA, cocamide MIPA, sucrose stearate acetate, hydrogenated palm kernel oil

Fatty acid glyceriz, hydrogenated palm oil fatty acid PEG-200 glyceryl, hydrogenated palm oil fatty acid

Glyceriz, sorbitan sesquiisostearate, polyglyceri sesquiisostearate

Lu-2, polyglyceryl-2 sesquicaprylate, PEG-20 methyl sesquistearate

Gu

Nonionic surfactants such as Lucour, sodium stearate, zinc stearate, stearate 50

 (28) JP 2018-90631 A 2018.6.14

Calcium phosphate, magnesium stearate, aluminum stearate, isoste

Aluminum alate, triethanolamine stearate, potassium palmitate, ce

Sodium tyl sulfate, sodium lauryl phosphate, disodium lauryl phosphate, palmi

Triethanolamine silicate, sodium polyoxyethylene lauryl phosphate, N-acid

Sodium ruglutamate, sodium palmitate, sodium laurate, laurin

Potassium acid, zinc laurate, triethanolamine laurate, sodium laurate

, Sodium lauryl sulfate, potassium lauryl sulfate, ammonium lauryl sulfate, lauri

Monoethanolamine Lusulfate, Diethanolamine Lauryl Sulfate, Trieta Lauryl Sulfate

Nooramine, sodium lauryl diaminoethylglycine, triethano alkyl sulfate

Luamine ether, funnel oil, linear dodecylbenzene sulfuric acid, polyoxyethylene cured nitrogen Ten

Castor oil maleic acid, acylmethyltaurine, fatty acid soap, α-acylsulfonate,

Alkyl sulfonate, alkyl allyl sulfonate, alkylnaphthalene sulfonate

, Alkyl Sulfate, POE Alkyl Ether Sulfate, Alkylamide Sulfate, Alkyl Li

Phosphate, POE alkyl phosphate, alkyl amide phosphate, alkiloyl alkyl tau

Phosphate, N-acylamino acid salt, POE alkyl ether carboxylate, alkyl sulfo

Succinate, sodium alkylsulfoacetate, acyl acetylate, acylation hydrolysis

Collagen peptide salt, perfluoroalkyl phosphate, soap base, potash stone

Hmm, zinc undecylenate, potassium-containing soap base, coconut oil fatty acid potassium, sulfated

Castor oil, sodium myristate, potassium myristate, zinc myristate, myristi

Magnesium oxyate, sodium oleate, potassium oleate, N-acyl-L-glu 20

Triethanolamine tamate, sodium N-acyl-L-glutamate, N-coconut oil

Fatty acid acyl-L-sodium glutamate, N-coconut oil fatty acid / hardened beef tallow fatty acid acyl

-Sodium L-glutamate, N-coconut oil fatty acid acyl-L-monosodium glutamate trietano

Luamine, stearoyl-L-disodium glutamic acid, N-hardened beef tallow fatty acid acyl

-Sodium L-glutamate, N-lauroyl-sodium L-glutamate, N-s

Thearoyl-L-glutamic acid, N-lauroyl-L-lysine, lauroyl-L-gluta

Triethanolamine Minate, L-Arginine Ethyl DL-Pyrrolidone Carboxylate,

N-coconut oil fatty acid acyl-L-arginine ethyl DL-pyrrolidone carboxylate, palm

Oil fatty acid sarcosine, coconut oil fatty acid sarcosine sodium, coconut oil fatty acid sarcosine

Ethanolamine, lauroyl sarcosine, sodium lauroyl sarcosine, lauroi 30

Rusarcosine triethanolamine, carboxylated polyoxyethylene tridecylae

Tersodium salt (3EO), sodium β-laurylaminopropionate, lauryl

Luaminopropionic acid solution, coconut oil fatty acid methyl taurine potassium, coconut oil fatty acid methyl ta

Sodium urin, sodium lauroylmethyl taurine, sodium lauryl sulfoacetate

, Coconut oil fatty acid methyl alanine sodium solution, coconut oil fatty acid triethanolamine solution,

Lauroylmethyl-β-alanine sodium solution, lauryl-N-carboxymethoxyethi

Lu-N-carboxymethylimidazolinium disodium dodecanoyl sarcosine, palm

Oil Alkyl-N-carboxyethyl-N-hydroxyimidazolinium betaine natriu

Alkyl-N-carboxyethoxyethyl-N-carboxyethyl imidazole

Nium disodium hydroxide, coconut oil alkyl-N-carboxymethoxyethyl-N 40

-Carboxymethylimidazolinium disodium hydroxide, coconut oil alkyl-N-

Carboxymethoxyethyl-N-carboxymethylimidazolinium disodium lauri

Lusulfuric acid, myristoylation methyl-β-alanine sodium solution, stearoyl methyl taurine

Sodium, sodium tetradecene sulfonate, natriu dodecylbenzene sulfonate

Dodecylbenzene sulfonate triethanolamine, sodium alkane sulfonate

, Ammonium Alkyl Sulfate, Natriu Octylphenoxydiethoxyethyl Sulfonate

Mu, palm oil alkyl magnesium sulfate triethanolamine, myristyl sulfate natriu

Mu, sodium cetostearyl sulfate, sodium oleyl sulfate, trietano oleyl sulfate

Luamine, polyoxyethylene lauryl ether sodium sulfate, polyoxyethylene

Lauryl ether ammonium sulfate (2EO), polyoxyethylene laurylate 50

 (29) JP 2018-90631 A 2018.6.14

Triethanolamine sulphate, polyoxyethylene alkyl ether ammonium sulphate (

3E. O. ) Liquid, polyoxyethylene alkyl ether diethanolamine sulfate (3E.

O. ) Liquid, polyoxyethylene alkyl ether triethanolamine sulfate (3EO.

) Liquid, polyoxyethylene alkyl ether sodium sulfate (3EO) liquid, hardened palm

Oil fatty acid Sodium glyceryl sulfate, polyoxyethylene (5) Coconut oil fatty acid Monoethano

Luamide phosphate, polyoxyethylene alkyl (12-14) ether phosphate

(2EO), (8EO), (10EO), polyoxyethylene laurylate

Luphosphoric acid, polyoxyethylene lauryl ether sodium phosphate, polyoxyethylene

Cetyl ether phosphoric acid, polyoxyethylene cetyl ether phosphate sodium, polyoki

Siethylene stearyl ether, polyoxyethylene cholesteryl ether, polyoxy Ten

Ethylene stearyl ether phosphoric acid, polyoxyethylene oleyl ether phosphoric acid, poly

Oxyethylene oleyl ether sodium phosphate, polyoxyethylene oleylate

Diethanolamine ruphosphate, polyoxyethylene alkyl phenyl ether phosphoric acid, po

Lioxyethylene alkyl phenyl ether phosphate triethanolamine, polyoxye

Tylene polyoxypropylene cetyl ether phosphoric acid, polyoxypropylene glyceryle

-Terphosphoric acid, polyoxypropylene butyl ether phosphoric acid, polyoxyethylene sulfo

Sodium lauryl succinate, coconut oil fatty acid ethyl ester sodium sulfonate, su

Dioctyl sodium ruhosuccinate, octylphenoxydiethoxyethyl sulphonic acid

Sodium, disodium lauryl sulfosuccinate, oleic acid amide disodium sulfosuccinate

Sodium, polyoxyethylene alkyl (C12-15) ether phosphoric acid, polyoxye 20

Tylenealkyl (C12-14) disodium sulfosuccinate (7EO), sulfoco

Polyoxyethylene lauroyl ethanolamide disodium succinate (5EO), a.

Sodium stearoyl lactate, undecilenoyl hydrolyzed collagen sodium, un

Decilenoyl Hydrolyzed Collagen Potassium, Undecyl Hydroxyethyl Imidazole Niu

Sodium mubetaine, hydrolyzed collagen sodium lauric acid, hydrolyzed coconut oil fatty acid

Sodium collagen, hydrolyzed coconut oil fatty acid, potassium collagen, coconut oil fatty acid hydrolyzed

Degraded collagen potassium solution, coconut oil fatty acid hydrolyzed collagen triethanolamine, a

Sostearoyl hydrolyzed collagen, isostearoyl hydrolyzed silk, isostearoi

Hydrolyzed Collagen Amino Methyl Propanediol Salt, Ethylenediamine-N, N, N

´, N´-Tetrakis (2-hydroxypropyl) dioleate, dodecanoyl sarco 30

Syn, sodium laurylaminodipropionate (30%), oleoyl sarcosine,

Myristoylation-β-alanine sodium solution, undecyl hydroxyethyl imidazoliniu

Sodium mubetaine, alkyl (C12,13,16) ammonium sulfate, alkyl (

C11,13,15) Triethanolamine sulfate (1), alkyl (C11,13,15)

) Triethanolamine sulfate (2), alkyl (C12-15) triethanolamine sulfate

, Alkyl (C12-14) Sulfate Triethanolamine, Alkyl (12,13) Sulfate

Sodium, polyoxyethylene alkyl ether triethanolamine sulfate (3EO)

.. ) Liquid, (C11-15) Palace-3 Sodium Sulfate, (C12,13) Palace-3 Sulfate

Sodium, (C12-15) Palace-3 Sodium Sulfate, (C12,13) Palace-3

TEA Sulfate, (C12,13) Palace-3 Sulfuric Acid (TEA / Na), PEG-3 Palm Fatty Acid 40

Amide MEA Na Sulfate, PEG-5 Palm Fatty Acid Amide MEA Phosphate, PEG-5 Lauryl

2Na sulfosuccinate citrate, PEG-5 ceteth-10 phosphate, PEG-25 butyl li

Acid, alkyl (C14-18) sodium sulfonate, alkyl (C20-22) phosphorus

Acid, Isolaures-4 Phosphate, Undecilenoylglycine, Olive Fatty Acid Potassium, O

Rail sarcosine, sodium oleylmethyltaurine, oleth-3 phosphate, oleth-4

Phosphoric acid, Oles-5 phosphoric acid, Oles-10 phosphoric acid, Oles-20 phosphoric acid, Oles-7 phosphorus

Sodium acid, oleth-8 sodium phosphate, olefin (C14-16) sulfonate

Thorium, capryloylglycine, cocoyl amino acid sodium, cocoyl alanine tri

Ethanolamine, Sodium Cocoyl Isetionate, Ammoniu Cocoyl Isetionate

Mu, cocoyl glycine potassium, cocoyl glycine sodium, cocoyl glutamine tri 50
 (30) JP 2018-90631 A 2018.6.14

Ethanolamine, cocoyl glutamic acid, disodium cocoyl glutamic acid, cocoy

Cocoyl glutamates such as potassium luglutamate, cocoyl sarcosine, cocoi

Sodium rusarcosine, cocoyl sarcosine triethanolamine, cocoyl taurine

Sodium, cocoyl methylalanine, cocoylmethylalanine sodium, cocoylme

Tiltaurine, cocoyl methyl taurine potassium, cocoyl methyl taurine magnesium

, Sodium cocoyl methyl taurine, sodium cocoyl apple amino acid, coses sulfate

Sodium, di (C11-15) palace-2 phosphate, di (C12-15) palace-4 phosphorus

Acid, Di (C12-15) Palace-8 Phosphoric Acid, Di (C12-15) Palace-10 Phosphoric Acid, Di

Oleyl Phosphate, Diores-8 Sodium Phosphate, Diores-8 Sodium Phosphate, Zico

Coil ethylenediamine PEG-15 sodium sulfate, dilaures-10 sodium phosphate Ten

Mu, steares-2 phosphate, steares-3 phosphate, stearoyl calcium lactate, stea

Sodium aloyl lactate, undecylenamide sulfosuccinate MEA-2Na, sulfosuccinate

Lauramide silicate MEA-2Na, sodium laureth sulfosuccinate, D cetyl phosphate

EA, Potassium Cetyl Phosphate, Sodium Cetearyl Sulfate, Ceteth-10 Phosphate, Ceteth

-20 Phosphoric Acid, Triceteares-4 Phosphoric Acid, Tricedes-4 Carboxylic Acid, Tricedes-8

Carboxylic Acid, Sodium Tricedes-4 Carboxylic Acid, Natriu Tricedes-7 Carboxylic Acid

, Tricedes-3 Sodium Acetate, Tricedes-7 Potassium Phosphate, Trilaureth-4

Phosphoric acid, oleyl lactate, palm fatty acid sodium glutamate, palmitoyl glutamine

Magnesium acid, palmitoyl sarcosine sodium, palmitoyl proline, palmito

Sodium ilproline, sodium palmitoylmethyltaurine, myristoylation gluta 20

Potassium mineral acid, sodium myristoyl glutamate, myristoyl sarcosine natori

Umm, myristoylation methyl taurine sodium, coconut fatty acid potassium, coconut fatty acid trie

Tanolamine, coconut fatty acid arginine, sodium lauraminodiacetate, laurylglyco

Sodium laureth acetate, laureth-5 carboxylic acid, laureth-6 carboxylic acid, laureth-1

1 Carboxylic Acid, Sodium Laureth-5 Carboxylic Acid, Sodium Laureth-6 Carboxylic Acid

, Sodium laureth-11 carboxylate, laureth-5 acetic acid, laureth-6 acetic acid, laureth

Su-4.5 potassium acetate, laureth-3 sodium acetate, laureth-4 sodium acetate,

La

Ures-5 Sodium Acetate, Laureth-6 Sodium Acetate, Laureth-11 Sodium Acetate

Laureth Sulfate MIPA, Sodium Laureth Sulfate, Triethanolamine Laureth Sulfate 30

Laureth-2 ammonium sulfate, laureth-3 ammonium sulfate, laureth-1 phosphorus

Acid, Laures-2 Phosphoric Acid, Laures-4 Phosphoric Acid, Sodium Lauroyl Aspartate,

Lauroyl oat amino acid sodium, lauroyl lactate sodium, lauroyl meth

Potassium lualanine, lauroylmethylalanine triethanolamine, disetyl phosphate

, Anionic surfactants such as cetyl phosphate, lauryltrimethylammonium chloride, chloride

Dicocoyldimethylammonium, myristyldimethylbenzylammonium chloride, chloride

Cetyltrimethylammonium, laurylpyridinium chloride, cetylpyridinium chloride,

Benzethonium chloride, stearyltrimethylammonium chloride, benzalkonium chloride

Umm, benzalkonium chloride solution, laurylamine oxide, alkyltrimethyla chloride

Nmonium, stearyltrimethylammonium chloride, stearyldimethylbenzyl chloride 40

Ammonium, dimethylstearyl ammonium chloride Hectorite, benzyldi chloride

Methylstearylammonium treated hectorite, distearyldimethylammoniu chloride

Didecyldimethylammonium chloride treated bentonite, dialkyldimethyl chloride

Ammonium, tri-(polyoxyethylene) stearylammonium (5EO)

, Di (polyoxyethylene) oleylmethylammonium (2EO), stee chloride

Alloy coliminoformylmethylpyridinium, polyoxypropylene methyldieti chloride

Luammonium, alkyldiaminoethylglycine hydrochloride solution, alkylisoquinoliniu bromide

Liquid, lauryltrimethylammonium bromide, cetyltrimethylammonium bromide, bromide

Stearyl trimethyl ammonium, cetyl trimethyl ammonium saccharin, steer

Liltrimethylammonium saccharin, polyethylene glycol epicleluhydrin 50

 (31) JP 2018-90631 A 2018.6.14

・ Coconut oil alkylamine dipropylene triamine condensate, polyethylene glycol d

Pyrochlorohydrin / beef tallow alkylamine dipropylene triamine condensate, lano ethyl sulfate

Phosphorus fatty acid aminopropylethyldimethylammonium (1), (2), behenilto bromide

Limethylammonium, behenic acid amidopropyldimethylhydroxypropylammonium chloride

Monium, diethylaminoethylamide stearate, dimethylaminopro stearate

Pyramide, lanolin derivative quaternary ammonium salt, PEG-5 oleamine, PEG-2

Oleammonium chloride, PEG-2 cocamine, PEG-3 cocamine, PEG-5 coca

Min, PEG-10 cocamine, PEG-15 cocamine, PEG-2 dimethoformami

Doethylmonium metosulfate, alkyl (C12,14) oxyhydroxypropi

Luarginine hydrochloride, alkyl (C16,18) trimonium chloride, isoalkyl ( Ten

C10-40) Amidopropyl ethyldimonium etosulfate, isostearylethi

Luimidazolinium etosulfate, Caesarpinia spinosa hydroxypropyltri

Monium chloride, quaternium-33, quaternium-91, cocamidopropyl PG di

Monium chloride acid, cocamidopropyl betaine amide MEA chloride, cocoyl al

Guinine ethyl PCA, cocotrimonium metosulfate, fenugreek hydroxypropyltrimoniu

Muchloride, acetic acid (myristamide / palmitamide) butylguanidine, dialkyl (C1)

2-18) Dimonium chloride, dicocoyl ethyl hydroxyethylmonium metosulf

Eat, dicocodimonium chloride, distearyl dimonium chloride, distearyl

Ethylhydroxyethylmonium metosulfate, disetyldimonium chloride, dipa

Lumitoylethyl hydroxyethylmonium metosulfate, dihydroxypropyl P 20

EG-5 Linole Ammonium Chloride, Dimethyl PABA Amidopropyl Raul Jimoni

Umtosilic acid, dimethyl stearamine, stearamide ethyldiethylamine, stearami

Dopropyldimethylamine, stearylconium chloride, stearyltrimonium sac

Karin, stealtrimonium chloride, stealtrimonium bromide, stearoxy

Propyltrimonium chloride, cetalconium chloride, cetylpyridinium chloride

, Setrimonium chloride, Setrimonium bromide, Setrimonium metosulfate

, Soitrimonium chloride, Palmitamidpropyltrimonium chloride, Pantenyl

Hydroxypropyl steardimonium chloride, hydroxyethylcetyldimonium li

Acid, hydroxypropyltrimonium honey, hydroxypropylbishydroxyethi

Ludimonium chloride, behenamide propyl dimethylamine, behenamide propyl dimethi 30

Luamine, Behentrimonium chloride, Behentrimonium metsulfate, Poroki

Samine 701, Poroxamine 702, Poroxamine 704, Bishydroxyethi malonic acid

Lucetylamide, coconut oil alkyl PG dimonium sodium chloride, laurilto

Limonium chloride, laurylpyridinium chloride, linoleamide propyl PG dimo

Cationic surfactants such as nium chloridephosphoric acid, betaine lauryldimethylaminoacetate

, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betai

Undecylic-N-hydroxyethyl-N-carboxymethylimidazolium betaine

, Coconut oil alkyl betaine, coconut oil fatty acid amide propyl betaine, stearyl dihydro

Xyethyl betaine, stearyldimethylaminoacetic acid betaine, bis (stearyl-N-

Hydroxyethyl imidazoline) Chloracetic acid complex, coconut oil fatty acid hydrolyzed collagen, o 40

Reoil Hydrolyzed Collagen, Hydrolyzed Collagen Hexadecyl, Laurate Amidopro

Pyrbetaine solution, myristoylation hydrolyzed collagen solution, alkylaminoethylglyci hydrochloride

Carboxybetaine type such as lecithin, amide betaine type, sulfobetaine type,

Droxysulfobetaine type, amide sulfobetaine type, phosphobetaine type, aminocarbo

Nate type, imidazoline derivative type, amidoamine type, PEG-3 lauramine oxide, o

Realamine oxide, oleyl betaine, (capryl / couplerid) propyl betaine, co

Coamine oxide, sodium cocoamphoacetate, sodium cocoamphodiacetate, cocoan

Sodium hodiacetic acid, sodium cocoa propionate, dihydroxyethyllaura

Minoxide, stearamine oxide, stearyl betaine, palm kernel fatty acid amidoethi

Sodium propionate luhydroxyethylaminopropionate, palm nuclear fatty acid amide propyl solid 50
 (32) JP 2018-90631 A 2018.6.14

In, hydroxyalkyl (C12,14) hydroxyethylalanine, heptadecylhi

Droxyethylcarboxylate Methylimidazolinium chloride / heptadecylbishi

Droxyethyl imidazolinium, myristamide propyl betaine, myristamine oxy

Do, myristyl betaine, lauramidopropyl amine oxide, lauramidopropyl hydride

Loxysultaine, lauramidopropyl betaine, sodium propionate,

Lauramine oxide, sodium lauriminodipropionate, lauryl hydroxysulta

Amphoteric kingdoms such as in, lauryl betaine, sodium lauroamphoacetate, and lauroyl lysine

Surfactant, escin, sodium surfactin, saponin, lecithin hydroxide, hydrogenated resort

Lecithin, hydrogenated lecithin, cephalin, phosphatidylserine, lysolecithin, phospholipids

, Lecithin, water-soluble collagen and the like can be exemplified. Of these surfactants, non- Ten

Ionic surfactants are preferred, for example polyoxyethylene alkyl ethers, polyoxy

Ethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, glycerin fat

Fat acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid d

Steal, polyoxyethylene sorbitol castor oil, polyoxyethylene sorbitol fatty acid S

Nonionic surfactants such as tell are more preferred.

[0070]

In particular, one or two of L-ascorbic acid, its derivatives, and salts thereof of the present invention.

In the case of a lotion containing a composition for external use on the skin containing more than seeds, the cosmetics may become turbid and precipitate over time.

It is preferable to use the following surfactants, which have a high inhibitory effect and are widely used in the cosmetics field.

I'm sorry. That is, L-arginine ethyl DL-pyrrolidone carboxylate, pyroglutami 20

Polyoxyethylene glyceryl acid isostearate, PEG-9 polydimethylsiloxy

Ethyldimethicone, coconut oil fatty acid sorbitan, polyoxyethylene polyoxypropylene

Decyl Tetra Decyl Ether, Polyoxyethylene Socetyl Ether, PolyoxyEchiré

Stearyl ether, polyoxyethylene methyl glucoside, polyoxyethylene lau

Lil ether, polyoxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil, a

Sorbitan sostearate, polyoxyethylene hydrogenated castor oil isostearate, glyce

Phosphorus fatty acid ester, polyglyceryl diisostearate, sucrose fatty acid ester, steat

Sodium aloyl glutamate, sodium stearoyl lactate, sesquiisostea

Sorbitan acid, sorbitan sesquioleate, polyoxyethylene alkyl (C12-1)

5) Ether phosphoric acid, polyoxyethylene cholesteryl ether, polyoxyethylene ce 30

Tyl ether phosphoric acid, polyoxyethylene setostearyl ether, polyoxyethylene

Phytosterol, polyoxyethylene behenyl ether, polyoxye monooleate

Tylene sorbitan (20EO), glycerin monostearate, polye monostearate

Tylene glycol, polyoxyethylene glyceryl monostearate, monolaurate po

Lioxyethylene sorbitan, dioctyldodecyl lauroyl glutamate, hydrolyzed

Large solution, glyceryl monostearate, hydrogenated soy lysophospholipid, hydrogenated soy li

One or more surfactants selected from lipids and water-soluble collagen alone or

It is desirable to use them in combination.

[0071]

In addition, the lotion contains the fragrances, pigments and preservatives listed below to improve its quality and stability. 40

Contains one or more selected from agents, bactericides, UV absorbers, metal sequestering agents and buffers

Each of them can usually be 0.0001 quality per lotion mass of the present invention.

Amount% or more, preferably 0.001 to 50% by mass, more preferably 0.01 to 25% by mass

%, More preferably in the range of 0.1 to 10% by mass.

[0072]

(Fragrance)

As fragrances, benzaldehyde, synamic aldehyde, cyclamen aldehyde,

Citral, citronellal, 2-methyl-3- (4-methylphenyl) -propanal

, Undecenal, methyl nonyl acetaldehyde, 3,7-dimethyl-1-octana

Lu, hydroxycitronellal, methoxycitronellal, perillaldehyde, myltena 50

 (33) JP 2018-90631 A 2018.6.14

Lu, caryophyllene aldehyde, n-hexanol, 2-methylbutanal, isobarrel

Aldehyde, n-valeraldehyde, acetaldehyde, n-heptanal, n-octa

Nar, n-nonanal, 2-methyloctanal, 3,5,5-trimethylhexanal

Le, 1-decanal, undecanal, dodecanal, 2-methyldecanal, 2-methi

Rundecanal, Tridecanal, Myristyl aldehyde, 2-Pentenal, cis-3

-Hexenal, trans-2-hexenal, trans-2-heptenal, 4-

Heptenal, trans-2-octenal, trans-2-nonenal, cis-

6-nonenal, 2,6-dimethyl-5-heptenal, trans-4-decenal,

cis-4-decenal, trans-2-decenal, 2,5,6-trimethyl-4-

Heptenal, 10-Undesenard, trans-2-Undesenal, trans- Ten

2-dodesenal, 3-dodesenal, trans-2-tridesenal, 2,6,10

-Trimethyl-9-Undecen-1-Ear, 2,4-Hexadienal, 2,4-Hep

Tadienal, 2,4-octadienal, 2,4-nonadienal, 2,6-nonazier

Nar, 2,4-Decadienal, 2,4-Undecazienal, 2,4-Dodecaziena

, 5,9-dimethyl-4,8-decadienal, 3,7,9-trimethyl-2,6-

Decadien-1-R, 2,6,10-trimethyl-5,9-Undecazienal, α

-Methylene citroneral, camphorene aldehyde, cyclocitral, isocyclosi

Slovenian tolar, 2,6,6-trimethyl-1,3-cyclohexadiene-1-carboxyal

Dehide, 6,10-dimethyl-3-oxa-9-undecenal, geranyloxyacet

Aldehyde, dimethyltetrahydrobenzaldehyde, 3-propylbicyclo [2,2 20

1] -5-Heptene-2-carboxyaldehyde, methoxydicyclopentadienecarbo

Xylaldehyde, 4-tricyclodecylidenebutanal, 4- (4-methyl-3-cyclo)

Hexenilidene-1) pentanal, 4 (3)-(4-methyl-3-penten-1-yl)

) -3-Cyclohexene-1-carboxyaldehyde, setneral, inonal, teres

Slovenian tolar, p-tolylaldehyde, phenylacetaldehyde, 3-phenylbutanal

, Cuminaldehyde, p-methylphenylacetaldehyde, p-isopropylphenyl

Acetaldehyde, hydratropaldehyde, p-methylhydratropaldehyde, p-

Isopropylhydratropaldehyde, phenylpropionaldehyde, β-methylhydride

Rosinnamic aldehyde, jasmoranji, bulgeonal, florarozone, suzara

Or, salicylaldehyde, anisaldehyde, o-methoxybenzaldehyde, o-me 30

Toxicinnamic aldehyde, cantoxal, vanillin, ethylvanillin, methylvanillin

Nirin (3,4-dimethoxybenzaldehyde), helional, phenoxyacetal

Dehide, p-methylphenoxyacetaldehyde, furfural, 5-methylfurfural

Le, 5-hydroxymethyl-2-furfural, frilled acrolein, lylar, Bern

Aldehyde, Homomylac aldehyde, Junipearl, Vertral, Lilial,

Mefranal, Egrantal, Cocal, α-Methyl Synnamic Aldehyde, α-B

Chill cinnamic aldehyde, α-amyl cinnamic aldehyde, α-hexyl cinna

Aldehydes such as Mickaldehyde, formylethyltetramethyltetralin, teacetate

Lepinel, betaberyl acetate, benzyl acetate, linalyl acetate, isopentyl salicylate, sa

Benzyl lithylate, hexyl salicylate, cis-3-hexenyl salicylate, formic acid 40

Chill, cis-3-hexenyl formate, linalyl formate, citronellyl formate, geranyl formate, gi

Benzyl acid, phenylethyl formate, ethyl acetate, butyl acetate, isoamyl acetate, cyclope

Methyl acetate, hexyl acetate, cis-3-hexenyl acetate, trans-2-acetate

Hexenyl, isononyl acetate, citronellyl acetate, lavandryl acetate, geranyl acetate,

Myrcenyl acetate, terpinyl acetate, menthyl acetate, mentanyl acetate, nopill acetate, n acetate

-Bornyl, isobornyl acetate, pt-butylcyclohexyl acetate, ot-buty acetate

Lucyclohexyl, tricyclodecenyl acetate, 2,4-dimethyl-3-cyclohexe acetate

N-1-methanyl, phenylethyl acetate, styralyl acetate, dimethylbenzyl carvi acetate

Nil, cinnamyl acetate, anisyl acetate, paracredyl acetate, heliotropil acetate, acetyl

Luoigenol, acetylisoeugenol, guayl acetate, sedrill acetate, propion 50

 (34) JP 2018-90631 A 2018.6.14

Ethyl acid acid, isoamyl propionate, citronellyl propionate, geranyl propionate

, Linalyl propionate, terpinyl propionate, benzyl propionate, propion

Synamyl acid acid, allyl cyclohexylpropionate, tricyclodecenyl propionate,

Ethyl butyrate, ethyl 2-methylbutyrate, butyl butyrate, isoamyl butyrate, hexyl butyrate, butyrate

Linalyl, geranyl butyrate, citronellyl butyrate, benzyl butyrate, cis-3-hexeisobutyrate

Nyl, citroneryl isobutyrate, geranyl isobutyrate, linalyl isobutyrate, benzyl isobutyrate

, Phenyl ethyl isobutyrate, Tricyclodecenyl isobutyrate, Ethyl isovalerate, Pus valerate

Lopil, citronellyl isovaleric, geranyl isovaleric, benzyl isovaleric, isovalerian

Synamyl acid acid, phenylethyl isovalerate, ethyl caproate, allyl caproate, ena

Ethyl tonate, allyl enanthate, ethyl caprate, citronellyl tiglic acid, benzoin Ten

Methyl benzoate, ethyl benzoate, isobutyl benzoate, isoamyl benzoate, gerani benzoate

Lu, linaryl benzoate, benzyl benzoate, phenylethyl benzoate, methiphenylacetate

Lu, ethyl phenylacetate, isobutyl phenylacetate, isoamyl phenylacetate, phenyl

Geranyl acetate, benzyl phenylacetate, phenylethyl phenylacetate, p-phenylacetic acid

Cresyl, Methyl Citrate, Ethyl Citrate, Benzyl Citrate, Cinnamyl Citrate, Flu Citrate

Enylethyl, methyl salicylate, ethyl salicylate, isobutyl salicylate, salicyl

Amil acid, hexyl salicylate, cis-3-hexenyl salicylate, phenyl salicylate

Ethyl, methyl jasmonate, methyl dihydrojasmonate, flutate, 2-pentyl

Allyl oxyglycolate, ethyl 3-methyl-3-phenylglycidate, ethyl 2-pe

Internoate, 4-acetoxy-3-amyltetrahydropyran, cyclohexyl salici 20

Rate, ethyl 2-cyclohexylpropionate, ethyltricyclo [5.2.1.02

, 6] Decane-2-carboxylate, 2-methylpentyl 2-methylpentylate, etc.

Esters, γ-undecalactone, pentalide (cyclopentadecanolide), Havano

Lido (oxacyclohexadecene-2-one), ambrettolide, cyclohexadecano

Lido, 10-oxahexadecanolide, 11-oxahexadecanolide, 12-oxahe

Xadecanolide, ethylene dodecanedioate, γ-butyrolactone, γ-valerolacto

, Angelica lactone, γ-hexalactone, γ-heptalactone, γ-octalactone

Gamma-nononalactone, 3-methyl-4-octanolide, γ-decalactone, γ-deca

Lactone, γ-jasmolactone, jasmine lactone, cis jasmon lactone, easy

Tojasmon, jasmo lactone, mentalactone, n-butylphthalide, propylidene 30

Phthalide, butylidene phthalide, δ-hexalactone, δ-octalactone, trivalon

, Delta-Nonalactone, δ-Decalactone, δ-2-Desenolactone, δ-Undecalacto

, Delta-dodecalactone, δ-tridecalactone, δ-tetradecalactone, lactosca

Tons (decahydro-4, α-hydroxy-2,8,8-trimethylnaphthalene-2-cal

Boxy acid-δ-lactone), coumarin, dihydrocoumarin, cyclohexyllacto

Lactones such as 6-methylcoumarin, ε-decalactone, ε-dodecalactone, a

Cetylcaryophyllene, Carvone, Pulegone, Piperitone, Piperitone, Shaw Brain, Lee

Solongiphoranone, nootkatone, 2-heptanone, 2-pentanone, 3-hexanone

, 3-Heptanone, 4-Heptanone, 2-Octanone, 3-Octanone, 2-Nonanone,

3-nonanone, 2-undecanone, 2-tridecanone, methyl isopropyl ketone, ethic 40

Isoamyl ketone, mesityl oxide, butylideneacetone, methylheptadienone

, Methylheptenone, dimethyloctenone, 4-methylene-3,5,6,6-tetramethy

Lu-2-heptanone, geranylacetone, farnesylacetone, acetoin, 5-hide

Loxy-4-octanone, methyl lavender ketone, diacetyl, 2,3-pentadione

, 2,3-Hexadione, 3,4-Hexadione, 2,3-Heptadione, Acetyliso

Valeryl, amylcyclopentanone, amylcyclopentenone, 2-cyclopentylsik

Lopentanone, hexylcyclopentanone, 2-n-heptylcyclopentanone, cis

-Jasmon, dihydrojasmon, isojasmon, trimethylpentylcyclopenta

Non-sedamon (2-butylidene-3,5,5 (3,3,5) -trimethylcyclopenta

Non), Sandex, Cycloten, 3,5-dimethyl-1,2-Cyclopentadione, 50

 (35) JP 2018-90631 A 2018.6.14

Methylcorylone, 2-tert-butylcyclohexanone, p-tert-butylcyclo

Hexanone, 3,3-dimethylcyclohexylmethylketone, 2-sec-butylcyclo

Hexanone, Artemon, Celery Ketone, Krypton, p-tert-Pentylcyclo

Hexanone, methylcyclocitron, neron, 4-cyclohexyl-4-methyl-2-pe

Ntanone, Havanol, Maltol, Ethyl maltol, Oxide Ketone, Emoxyf

Ron, homoflor, sotolon, furaneol, acetyldimethylfuran, furfural

Acetone, 2-Acetyl-5-Methylfuran, 2-Acetylfuran, Methyltetrahydro

Furanone, Dibenzylketone, Benzophenone, Methylnaphthyl Ketone, 4-Damasco

, 4-Methyl-4-phenyl-2-pentanone), α-methylanisalacetone, helicopter

Otropylacetone, anicylideneacetone, anisylacetone, p-methoxyphenyl Ten

Acetone, Raspberry Ketone, Labandzone, Benzylideneacetone, p-methoxyacet

Tophenone, p-methylacetophenone, propiophenone, acetophenone, isodama

Sukon, α-Dynascon, Iriton, Ionone, Psoid Ionone, Methyl Ionone, Methyl

Iriton, 2,4-di-tert-butylcyclohexanone, allylyonone, 2,6,6

-Trimethyl-2-cyclohexene-1,4-dione, 2-acetyl-3,3-dimethyl

Norbornane, Rolex, Prikaton, Oxosedran, Beltfix, Velve

Non, Fenchone, Karon, Trimofix O, Epiton, Atrinon, Cashmeran

, 3-Methylcyclopentadecanol-1, Cycloheptadeca-9-en-1-one, Siku

Lopentadecanone, cyclohexadecenone, fantaside, 4-acetyl-6-tert

-Butyl-1,1-dimethylindane, tratheolide, tonalide, vitaminide, dihydro 20

Ketones such as locarbonate, diosphenol, zingerone, iso E super, phenyl

Acetic acid, sandalool, linalool, muskketone, methylionone, iris oil, iron,

Indole, ylang-ylang oil, estragole, oakmoss, opoponax resinoid

, Eugenol, Oranthiol, Galax Solid, Carvacrol, L-Carvone,

Mosquito

Enfer, cannon, carrot seed oil, clove oil, geraniol, geranyl pyrophosphate

Le, sandalwood oil, cyclopentadecanolide, dihydromilsenol, jasminea

Busorut, cinnamon bark oil, 1,8-cineole, stilax resinoid, seda

-Wood oil, cedrene, cedrol, celery seed oil, thyme oil, damascon, damaseno

, Thymol, Tuberose Absolute, Decalactone, Terpineol, γ-Tel 30

Pinene, triplar, 2,6-nonadienol, nonalactone, patchouli alcohol,

Patchouli oil, phenethyl alcohol, petitgrain oil, cis-3-hexenol, Peru

Balsam, vetiver oil, vetiverol, peppermint oil, pepper oil, heliotropin, beetle

Lugamot oil, borneol, mill resinoid, menthol, L-menthol, L-men

Ton, eucalyptus oil, β-yonon, lime oil, lavender oil, D-limonene, lemon oil, b

'S Absolute, Rose Oxide, Rose Oil, Rosemary Oil, Asafetida Regino

Id, Ajowan oil, Star anise oil, Avies oil, Amyris oil, Amblet seed oil

, Ambergris tincture, ylang-ylang absolute, ylang-ylang, ylang-ylang

Solute, wintergreen oil, elemioleoresin, elemiresinoid absolute

Oakmoss, Elemitinki, Oakmoss Concrete, Oakmoss Absolute, Oakmoss 40

Resin, Oakmoss Resinoid, Ocotia Oil, Ottoman Sus Absolute, Ottoman

Sus concrete, opopanax resinoid, opopanax absolute, opopa

Nax Oil, Oliver Nam Resinoid, Oliver Nam Absolute, Oliver Nam Oil, All

Spice oil, oregano oil, oregano oledin, orange flower absolute, oren

Diflower concrete, Kananga oil, Garjun balsam, Garjun balsam oil, Ka

Scarila Bak Oil, Castorium Absolute, Cassie Absolute, Cassif

Lour oil, Cassia oil, Gardenia absolute, Carnation absolute, Turnip

Luba oil, chamomile oil, cardamom oil, galbanum oil, galbanum resin, galbanum

Resinoid, caraway seed oil, guayak wood oil, guayak resin, guayak

Cumin concrete, camphor oil, cubeb oil, cumin oil, cumin absolute, cumin ole 50
 (36) JP 2018-90631 A 2018.6.14

Olesin, clary sage oil, grapefruit oil, costas oil, copaiba balsam, copa

Iva Balsam Oil, Copaiba Balsam Resin, Coriander Oil, Sassafras Oil, Genea

Juniper oil, perilla oil, citronella oil, jasmine concrete, juniper berry oil,

Civet Absolute, Civet Tincture, John Kill Absolute, Agarwood Oil

, Ginger oil, cinnamon oil, cinnamon leaf oil, sugi oil, stylux oil, spearmin

Oil, savory oil, sage oil, cedar oil, cedar leaf oil, tagget oil, tarragon oil,

Dill oil, tea tree oil, trimos absolute, trobalsam, nutmeg oil

, Narcissus Absolute, Neroli Oil, Violet Leaf Absolute, Pine Oil

, Basil oil, parsley leaf oil, parsley seed oil, parsley herb oil, peppermint oil, vanilla ab

Solut, Honeysuckle Absolute, Palmarosa Oil, Valerian Oil, Bitao Ten

Range oil, hyssop oil, hiba oil, hyacinth absolute, fennel oil, figab

Solut, buthu oil, pennyroyal oil, peppermint oil, benzoin tincture, benzo

Inresinoid, boad rose oil, sardine oil, hop oil, hop concrete, hot

Puabsolute, marjoram oil, mandarin oil, orange oil, mimosa concrete,

Mimosa Absolute, Mimosa Oil, Mill Absolute, Mill Oil, Musk Absolute

Mugwort, Musktinki, Yuzu oil, Mugwort oil, Labdanum oil, Labdanum resinoid, La

Bender Absolute, Lavandula Oil, Lavandula Absolute, Linaroe Oil, Remo

Glass oil, rose concrete, lavage oil, laurel oil, laurel leaf oil, worm

Wood oil, musk, sacred cat incense, dragon incense, castoreum, musk chibata, α-pinene, β-pinene

, Camphene, Myrcene, Tarpineol, Tarpinolene, Ocimene, γ-Tarpinen, 20

α-Phellandrene, p-cymen, β-caryophyllene, β-farnesene, 1,3

5-Undecatorien, hydrocarbons such as diphenylmethane, anisyl alcohol, sinnami

Alcohol, phenylpropyl alcohol, dimethylbenzyl carbinol, pheni

Ruethylmethylethylcarbinol, 3-methyl-5-phenylpentanol, orcino

Lumonomethyl ether, isoeugenol, santalol, isobornylcyclohexa

Noor, Sandaloa, Bagdanor, Sandals My Solcore, Bramanol, Evanol

, Polysantol, 2-ethoxy-4-methoxymethylphenol, trans-2-hex

Senol, cis-3-hexenol, 3-octanol, 1-octen-3-ol, 2

, 6-Dimethyl-2-heptanol, 9-decenol, 4-methyl-3-decene-5-o

Lu, 10-undecenol, trans-2-cis-6-nonazienol, nerol, si 30

Tronerol, rhodinol, rhodinol, lavandulol, tetrahydrogeranio

Le, tetrahydrolinalool, hydroxycitronellol, diaper diaper, tarpine

N-4-all, Isopulegol, Nopol, Farnesol, Nerolidol, Visaboro

Lu, patchouli alcohol, 2,4-dimethyl-3-cyclohexene-1-methanol,

4-Isopropylcyclohexanol, 4-Isopropylcyclohexanemethanol 1-

(4-Isopropylcyclohexyl) -ethanol, 2,2-dimethyl-3- (3-methi)

Ruphenyl) -propanol, pt-butylcyclohexanol, ot-butylsik

Lohexanol, ambrinol, benzyl alcohol, phenylethyl alcohol, fu

Alcohols such as enoxyethanol and styralyl alcohol, methyldihydrojas

Monate, Tetrahydrofurfuryl 3-Mercaptopropionate, Covanol, Zerani 40

Umm oil, birch oil, alumose oil acetylsedrene, amylsinnamarde

Hyd, allyl amyl glycolate, β-ionone, isobutyl quinoline, nerol oxa

Id, Miloxide, Rose Oxide, Limetol, Mentofuran, Linalool Oxa

Id, butyldimethyldihydropyran, acetoxyamyltetrahydropyran, sedrill

Methyl ether, methoxycyclododecane, 1-methyl-1-methoxycyclododecane,

Ethoxymethylcyclododecyl ether, tricyclodecenyl methyl ether, rubofi

X, sedroxide, umbroxane, glycalva, boisiris, anisole, dime

Chill hydroquinone, paracredyl methyl ether, acetanisole, anethole, di

Hydroanethole, diphenyloxide, methyl eugenol, methyl eugenol

Lu, benzyl isoeugenol, phenylethyl isoamyl ether, δ-naphthylmethi 50

 (37) JP 2018-90631 A 2018.6.14

Luether, δ-naphthyl ethyl ether, δ-naphthyl isobutyl ether, 2,4-

Dimethyl-4-phenyltetrahydrofuran, galaxolide, 2,2,5,5-tetra

A combination of various essential oils such as ethers such as methyl-4-isopropyl-1,3-dioxane

Examples include adult fragrances, natural fragrances, and various blended fragrances.

[0073]

(Dye)

The pigments include annatto, crocin, capsanthin, cissonin, hibiscus pigment, and gu.

Leepskin extract, safrole yellow, cocoa pigment, laccanic acid, carmi

Acid, curcumin, betanin, monascorbrin, brazilin, caramel, safflower pigment

, Gardenia jasminoides pigment, Sikon pigment, Cochineal pigment, anthraquinone pigment, Ann Ten

Tocyanin, chalcone, carotenoid, flavonoid, flavin, quinone,

Natural colorants such as porphyrin-based, diketone-based, and pentacyanidine-based pigments, photosensitizer 10

Photosensitizers such as No. 1, Photosensitizer 201, Photosensitizer 301, Photosensitizer 401, Red No. 2, Red

No. 3, Red No. 102, Red No. 104, Red No. 105, Red No. 106, Red No. 201, Red

202, Red 203, Red 204, Red 205, Red 206, Red 207,

Red 208, Red 213, Red 214, Red 215, Red 218, Red 219

No., Red No. 220, Red No. 221, Red No. 223, Red No. 225, Red No. 226, Red No. 2

No. 27, Red No. 228, Red No. 230, Red No. 231, Red No. 232, Orange No. 201, Orange

Color 203, Orange 204, Orange 205, Orange 206, Orange 207, Yellow 4, Yellow

Color 5, Green 3, Green 201, Green 202, Green 204, Green 205, Yellow 2 20

01, Yellow 202, Yellow 203, Yellow 204, Yellow 205, Yellow 401, Yellow

Color 402, Yellow 403, Yellow 404, Yellow 405, Yellow 406, Yellow 407

, Green 401, Green 402, Blue 403, Purple 401, Black 401, Blue 40

No. 4, Red No. 401, Red No. 404, Red No. 405, Red No. 501, Red No. 502, Red

503, Red 504, Red 506, Orange 401, Orange 402, Orange 403,

Red No. 505, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 202, Blue No. 203,

Blue 204, Blue 205, Brown 201, Purple 201 Zirconium, Barium

Is an organic pigment powder such as aluminum rake, the above organic powder is a shikon pigment, and a safflower pigment.

Examples of pigments containing natural pigments or synthetic organic pigments can be exemplified.

[0074] 30

(Preservative or fungicide)

Preservatives or fungicides include phenol, parachlorophenol, parachloromethacre

Zol, parachloromethaxylenol, resorcinol, resorcin monoacetate, ortho

Phenylphenol, isobutylparaben, ethylparaben, sodium ethylparaben

, Butylparaben, butylparaben sodium, propylparaben, propylparavenna

Alki paraoxybenzoate such as thorium, methylparaben, methylparaben sodium

Ruester, phenoxyethanol, thymol, cresol, hinokitiol, hydrochi

Phenols such as sibenzathiol, benzoic acid and its salts, salicylic acid and its salts

, Sorbic acid and its salts, Dehydroacetic acid and its salts, 2,4,4'-trichloro-2

´-Hydroxydiphenyl ether, hexachlorophene, bitionol, dichlorofe 40

Halogenated bisphenols, 3,4,4'-trichlorocarbanilide, 3-to

Rifluoromethyl 4,4'-dichlorocarbanilide, 3,4', 5-tribromosalityl

Anilide, p-aminobenzenesulfonamide, undecylenoic acid monoethanolamide

Which amides, benzalkonium chloride, alkylisoquinolinium bromide, benzetoni chloride

Umm, cetylpyridinium chloride, decalinium chloride, alkyltrimethylammoniu chloride

Quaternary ammonium compounds such as amine, alkylaminoethylglycine chloride, steari chloride

Zwitterionic surfactants such as sodium ruhydroxyethyl betaine, chlorgluconate

Hexidin, tetramethylthiuram disulfide, Photosensitizer 101, Photosensitizer 201,

Photosensitizers such as Photosensitizer 301, Photosensitizer 401, Photosensitizer NK-143, 1-Hydroki

Sipyridine-2-thione (zinc pyrithione), imidazolidinyl urea, N-triclo 50

 (38) JP 2018-90631 A 2018.6.14

Lomethyl mercapto-4-cyclohexene 1,2-dicarboxyimide, lysocy chloride

Mu, chlorphenesin, chlorobutanol, 2-brom-2-nitro-1,3-propane

Diol, anise oil, sea lion oil, citronellol, eugenol, benzylal

Cole, ethanol, 1,3-butylene glycol, hexylene glycol, dipropire

Diol, glycerin, 1,2-propanediol, 1,2-butanediol, 1,

2-Pentanediol (pentylene glycol), 1,2-hexanediol, 1,2-

Heptane diol, 1,2-octane diol, 1,2-nonane diol, 1,2-deca

Alcohols such as diol, parachlormethacresol, chlorhexidine chloride, bi

Su (2-pyridylthio-1-oxide) zinc, thiantoll, isopropylmethylpheno

, 6-acetoxy-2,4-dimethyl-m-dioxane, 5-chloro-2-methyl- Ten

4-isothiazolin-3-one, 2-methyl-4-isothiazolin-3-one, chlorine, next

Sodium chlorite, salashi powder, iodine, formaldehyde, glutaaldehyde, pi

Diethyl carbonate, ethylene oxide, β-propiolactone, hydrogen peroxide solution, sulfur,

Potassium gluconate, DMDM hydantoin, alkyl (C12-14) diethylamino

Ethylglycine hydrochloride, quaternium-80, quaternium-87, chloramine-T, shime

N-5-ol, propyl iodide butylcarbamate, polyaminopropyl biguanide,

Methylisothiazolinone, methylchloroisothiazolinone, dimethylaminostiliiodide

Luheptylmethylthiazolium and the like can be exemplified. Also, Echinashi leaf extract,

Oubaku extract, olive leaf extract, orange juice, capillary wormwood extract, kanzo hula

Bonoid, Kumazasa extract, Grapefruit extract, Chlorphenesin, Honeysuckle 20

Also plant extracts such as kiss, phenoxyethanol, saxifraga extract, sanguisorba extract

It can be advantageously used as an antibacterial agent.

[0075]

Among the above antibacterial agents, especially 1,2-alkanediol and 1,3-butylene glycol

Which non-paraoxybenzoic acid ester antibacterial agent has low skin irritation and high antiseptic effect

It is preferable from the viewpoint of smoothness and moisturizing property. The 1,2-alkanediol has 4 to 10 carbon atoms.

1,2-Alkanediol is preferred, especially 1,2-pentanediol (pliers).

Lenglycol), 1,2-hexanediol, 1,2-heptanediol and 1,2-

One or more 1,2-alkanediols selected from octanediols are Asco

Advantageous use due to its particularly excellent compatibility with rubic acid 2-glucoside and its sodium salt 30

it can.

[0076]

(UV absorber)

UV absorbers include para-aminobenzoic acid and monoglycerin-es para-aminobenzoic acid.

Tel, N, N-dipropoxyparaaminobenzoic acid ethyl ester, N, N-diethoxypa

Laaminobenzoic acid ethyl ester, N, N-dimethylparaaminobenzoic acid ethyl ester

, N, N-Dimethylpara-aminobenzoic acid butyl ester and other para-aminobenzoic acid-based ultraviolet rays

Absorption of anthranilic acid-based UV rays such as absorbents and homomentyl-N-acetylanthranilate

Collectant, cinnamic acid, oxybenzone-3, oxybenzone-4, oxybenzone-5, oxy

Benzophenone derivatives such as benzone-9, 1,3-propanedione derivatives with sugar or sugar 40

Alcohol-bonded sugar-based UV absorber, salicylic acid and its sodium salt, Amilsari

Silate, Mentil Salicylate, Homomentyl Salicylate, Octyl Salicylate,

Phenyl salicylate, benzyl salicylate, p-isopropanol Phenyl salicile

Salicylic acid-based UV absorbers such as dipropylene glycol salicylate, octylcin

Namet, ethyl-4-isopropylcinnamate, methyl-2,5-diisopropylsi

Nnamete, ethyl-2,4-diisopropylcinnamate, methyl-2,4-diisop

Lopilcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoki

Cicinnamate, isoamyl-p-methoxycinnamate, 2-ethylhexyl p-meth

Xycinnamate, 2-ethoxyethyl-p-methoxycinnamate (cinoxate),

Cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate 50
 (39) JP 2018-90631 A 2018.6.14

2-Ethylhexyl α-cyano-β-phenylcinnamate (octocrine), gut

Lycerylmono-2-ethylhexanoyl-diparamethoxycinnamate, ferulic acid and

Cinnamic acid-based UV absorbers such as its derivatives, 2,4-dihydroxybenzophenone, 2,2'

-Dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-di

Methoxybenzophenone, 2,2', 4,4'-tetrahydroxybenzophenone, 2-

Hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methi

Lubenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate,

4-Phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-

2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hide

Benzophenone-based UV absorbers such as Roxy-3-carboxybenzophenone, 3- (4') Ten

-Methylbenzylidene) -d, l-camphor, 3-benzylidene-d, l-camphor

, 2-Phenyl-5-methylbenzoxazole, 2,2'-hydroxy-5-methylfe

Nylbenzotriazole, 2- (2'-hydroxy-5'-t-octylphenyl) ben

Zotriazole, 2- (2'-hydroxy-5'-methylphenylbenzotriazole,

Dibenzalazine, dianisoil methane, 5- (3,3-dimethyl-2-norbornylidene)

) -3-Pentane-2-one, 4-methoxy-4'-t-butyldibenzoylmethane, 4

-Dibenzoylmethane derivatives such as t-butylmethoxydibenzoylmethane, octylmethane

Urocanic acid derivatives such as azone, urocanic acid and ethyl urocanate, 2- (2'-hi

Droxy-5'-methylphenyl) benzotriazole, 1- (3,4-dimethoxyfe)

Nyl) -4,4-dimethyl-1,3-pentandione, dimethoxybenzylidenedioxo 20

Imidazolidine octyl propionate, dimethoxybenzylidene dioxoimidazolidine

Hydantoin derivatives such as 2-ethylhexyl propionate, phenylbenzimidasozo

Lusulfonic acid, terephthalilidene dicamphor sulfonic acid, drometrizole trisiloxa

Oryzanol and its derivatives, octin, methyl anthranilate, rutin and its derivatives

Chilldimethylparaaminobenzoate, titanium oxide, zinc oxide, kaolin, talc, eth

Luhexyl triazone, octocrylene, dimethyl PABA octyl, homosalate, me

Tylenebis benzotriazolyl tetramethylbutylphenol, ethyl methoxycinnamate

Hexyl, octyl methoxycinnamate and the like can be exemplified.

[0077]

(Metal sealant) 30

As metal sequestering agents, ethylenediaminetetraacetic acid (EDTA), EDTA2Na, EDT

Ethylenediaminetetraacetic acid salts such as A3Na and EDTA4Na, hydroxyethylethyle

Hydroxyethylethylenediamine triacetate, such as trisodium diamine triacetate,

Phytic acid, diethylenetriamine pentaacetate, phytic acid, etidronic acid, etc.

Salts such as acid and its sodium salt, sodium oxalate, polyaspartic acid, polyg

Polypolyamino acids such as rutamic acid, sodium polyphosphate, sodium metaphosphate,

Acid, pyrophosphate, hexametaphosphate, sodium citrate, citric acid, alanine,

Dihydroxyethylglycine, gluconic acid, succinic acid, tartaric acid, etc. can be exemplified.

To.

[0078] 40

(Buffering agent)

As a buffer (pH adjuster), citric acid, sodium citrate, lactic acid, sodium lactate

Glycolic acid, succinic acid, acetic acid, sodium acetate, potassium acetate, malic acid, tartaric acid

, Fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, boric acid, borax, nitrilotoriethanol, monoeta

Nordamine, diethanolamine, triethanolamine, isopropanolamine,

Triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2

-Amino-2-hydroxymethyl-1,3-propanediol, arginine, amine hydroxide

Monium, sodium hydroxide, potassium hydroxide, calcium hydroxide, magnesium hydroxide

, Potassium hydrogen phosphate Ammonia water, Guanidine carbonate, Ammonium carbonate, Natriu carbonate

, Potassium carbonate, potassium bicarbonate, sodium bicarbonate, magnesium oxide, calcium oxide 50
 (40) JP 2018-90631 A 2018.6.14

Umm, ammonium phosphate, sodium monohydrogen phosphate, sodium dihydrogen phosphate phosphate

Thorium, potassium phosphate, magnesium phosphate, calcium phosphate, sodium borate

, Sodium metaborate, potassium citrate and the like can be exemplified.

[0079]

In particular, the lotion containing the external composition for skin of the present invention is widely used in the cosmetics field.

Sodium enoate, glycolic acid, succinic acid, sodium monohydrogen phosphate, dihydrogen phosphate

One or more buffers selected from thorium, sodium hydroxide, potassium hydroxide

In combination, the pH of the cosmetic solution of the present invention is usually pH 5 to 9, preferably pH 6 to.

8. More preferably, it is particularly desirable to use an amount that can be adjusted to the pH range of 6.5 to 7.5.

Good. Ten

[0080]

<Facial cleanser>

The external composition for skin of the present invention is used as a face wash by blending a component having a cleansing action.

Can be For dirt on the skin, dirt due to the natural physiological action of the skin, that is,

In addition to the sebum film that has been rancid and altered and the stratum corneum has peeled off, dirt such as dust in the air

There are cosmetics that are mixed and integrated, and cosmetics that are used daily, and facial cleansers wash away these and skin.

Used almost daily to keep the skin clean. Specific examples of facial cleansers include soap and body soap.

Examples include cleansing cream and make-up remover. Detergency

Examples of the minutes include alkaline salts of higher fatty acids (soap), and alkaline salts of higher fatty acids are

Mainly C 10 To C 18 Sodium salt, potassium salt and amine salt of fatty acids. 20

[0081]

Facial cleansers include fragrances, pigments, antioxidants and metal seals to improve and stabilize quality.

One or more selected from the chaining agents can be blended, each of which is usually a book.

0.0001% by mass or more, preferably 0.001 to 50% by mass, per mass of face wash of the present invention.

%, More preferably 0.01 to 25% by mass, still more preferably 0.1 to 10% by mass.

Formulated in a range. The fragrances, pigments and metal sequestering agents are those described in detail in the section on cosmetics.

Can be used as appropriate. As the antioxidant, for example, the antioxidants described below are suitable.

It can be used as desired.

[882]

(Antioxidant) 30

Antioxidants include retinol, dehydroretinol, retinyl acetate, palmitic acid

Vitamin A such as retinol acid, retinal, retinoic acid, vitamin A oil and them

Derivatives and salts thereof, α-carotene, β-carotene, γ-carotene, cryptoxane

Carotenoids such as chin, astaxanthin, fucoxanthin and their derivatives, pyrido

Xin, pyridoxal, pyridoxal-5-phosphate ester, pyridoxamine, etc.

B vitamins, their derivatives and their salts, ergocalciferol, korekarushifu

Vitamin Ds such as erol, 1,2,5-dihydroxy-cholecalciferol, it

Derivatives and their salts, α-tocopherol, β-tocopherol, γ-tocophero

Lu, δ-tocopherol, α-tocotrienol, β-tocotrienol, γ-tocoto

Rienol, delta-tocotrienol, tocopherol acetate, tocopherol nicotinate 40

Which vitamin Es, their derivatives and their salts, trolox, its derivatives and it

Salts, dihydroxytoluene, butylhydroxytoluene, butylhydroxyaniso

Lu, dibutylhydroxytoluene, α-lipoic acid, dehydrolipoic acid, glutathione, its attraction

Conductors and their salts, erythorbic acid, erythorbic acid, sodium erythorbate, etc.

Acids, their derivatives and their salts, gallic acid, gallic acid such as propyl gallate, their attraction

Conductors and their salts, rutin, rutin such as α-glycosyl-rutin, its derivatives and their derivatives

Their salts, tryptophan, its derivatives and their salts, histidine, its derivatives and theirs

Their salts, N-acetylcysteine, N-acetylhomocysteine, N-octanoylsis

Cysteine derivatives such as stain and N-acetylcysteine methyl ester and salts thereof

, N, N'-diacetylcystine dimethyl ester, N, N'-dioctanoylcystine 50

 (41) JP 2018-90631 A 2018.6.14

Siths such as dimethyl ester, N, N'-dioctanoyl homocystine dimethyl ester

Chin derivatives and their salts, carnosine and its derivatives and their salts, homocarnosine

And its derivatives and their salts, anserine and its derivatives and their salts, carcinin

And its derivatives and their salts, histidine and / or tryptophan and / or hista

Dipeptides or tripeptide derivatives containing min and salts thereof, flavanones, flavones,

Anthocyanins, anthocyanidins, flavonols, quercetin, quercitrin, milli

Setin, fisetin, hamamelitannin, catechin, epicatechin, galocatechin, epi

Flavonoids such as galocatechin, epicatechin gallate, epigallocatechin gallate

, Tannic acid, caffeic acid, ferulic acid, protocatechuic acid, chalcone, oryzanol, cal

Nosol, sesamol, sesamin, sesamolin, zingerone, curcumin, tetrahydro Ten

Curcumin, clobamide, deoxy clobamide, shogaol, capsaicin, vaniri

Luamide, ellagic acid, bromphenol, flavoglassine, melanoidin, riboflavin

, Riboflavin butyrate, flavin mononucleotide, flavin adenine creoti

Do, ubiquinone, ubiquinol, mannitol, bilirubin, cholesterol, ebsele

, Selenomethionine, ceruloplasmin, transferrin, lactoferrin, alb

Min, superoxide dismutase, catalase, glutathione peroxidase, me

Talotionenein, thioredoxin, thiotaurine, O-phosphono-pyridoxylidenelo

Damine and N- (2-hydroxybenzyl) amino acids, their derivatives and their salts, and

And N- (4-pyridoxyl methylene) amino acids, their derivatives and their salts, Rishi

, 1-Methionine, Proline, Silymarin, Tea Extract, Grape Bark / Seed Extract, Mela 20

Examples include nin, rosemary extract and the like.

[0083].

(Other ingredients)

Facial cleansers also include glycerin, ethanol, sugar, polyhydric alcohols and disinfectants

One or more selected species can be blended. As a disinfectant, see the section on lotion.

Preservatives and bactericides described in detail can be used as appropriate, but in the case of soap-based cleaning agents such as face wash.

Chlorhexidine hydrochloride, isopropylmethylpheno, for the purpose of disinfection, sterilization and deodorization

Lu, Photosensitizer 101, Cresol, Chloroxylenol, Chile Chloroxylenol, Halo

Calvin, Phenol, Chlorcresol, Phenoxyethanol, Trichlorhydroki

It is preferable to use sidiphenyl ether or the like. 30

[0084]

<Essence>

The external composition for skin of the present invention is a beauty essence by blending a moisturizer and an emollient.

Can be. In general, beauty essence, unlike lotion, has a viscosity and a feeling of use.

It is a type of cosmetic with excellent moisturizing properties, and is considered to have moisturizing and emollient functions.

There is. As the moisturizer and emollient agent, those mentioned above in the section of lotion should be used as appropriate.

Can be done. As the dosage form, a solubilized type, an O / W emulsified type, and an oil solution type are known.

[0085]

In general, serums are also fragrances, UV absorbers, whitening agents, anti-inflammatory agents, preservatives and bactericides.

By blending one or more selected from, other than moisturizing function and emollient function 40

Most of them claim the function of. Of the above ingredients, fragrances, UV protection agents, preservatives and

As for the disinfectant, each component described in detail in the section of the lotion can be appropriately used.

.. As the whitening agent and anti-inflammatory agent, for example, the whitening agent and anti-inflammatory agent described below are appropriately used.

Can be

0083.

(Whitening agent)

On the other hand, whitening agents include 3-methoxysalicylic acid, 3-ethoxysalicylic acid, and 4-meth.

Xisalicylic acid, 4-ethoxysalicylic acid, 4-propoxysalicylic acid, 4-isopropo

Xissalicylic acid, 4-butoxysalicylic acid, 5-methoxysalicylic acid, 5-ethoxysali

Alkoxysalicylic acids such as tylic acid and 5-propoxysalicylic acid and their salts, Hyde 50
 (42) JP 2018-90631 A 2018.6.14

Roquinone, arbutin, α-arbutin, hydroquinone α-L-glucose, hydro

Quinone β-L-glucose, hydroquinone α-D-galactose, hydroquinone β-

D-galactose, hydroquinone α-L-galactose, hydroquinone β-L-gala

Kutos, hydroquinone α-D-ribose, hydroquinone β-D-ribose, hyde

Loquinone α-L-ribose, hydroquinone β-L-ribose, hydroquinone α-D-

Arabinose, Hydroquinone β-D-Arabinose, Hydroquinone α-L-Arabino

S, hydroquinone β-L-arabinose, hydroquinone α-D-glucosamine, c

Idroquinone β-D-Glucosamine, Hydroquinone α-L-Glucosamine, Hydroquinone

Non-β-L-glucosamine, hydroquinone α-D-galactosamine, hydroquinone β

-D-galactosamine, hydroquinone α-L-galactosamine, hydroquinone β-L Ten

-Galactosamine, hydroquinone α-D-glucuronic acid, hydroquinone β-D-glu

Chronic acid, hydroquinone α-L-glucuronic acid, hydroquinone β-L-glucuronic acid

, Hydroquinone α-D-Galacturonic Acid, Hydroquinone β-D-Galacturonic Acid, C

Uro such as idroquinone α-L-galacturonic acid and hydroquinone β-L-galacturonic acid

Hydroquinone such as acid glycosides and derivatives of hydroquinone such as sugar glycosides, Tranexa

Mucic acid and its derivatives and their salts, resorcin or 4-n-butyl resorcinol

Which resorcin derivative, kojic acid and its derivatives and their salts, ellagic acid and linoleic acid

And their salts, anise extract, Japanese knotweed (Japanese knotweed) extract, onibasiri extract, shrimp

Sugusa extract, Ketsumeishi (Ketsumeishi) extract, Ougi (Huangqi) extract, Astragalus membranaceus extract

Thing, Trichosanthes trifolia (carocon) extract, cocklebur (blue ear child) extract, Gastrodia elata (Tenma) 20

) Extract, Kakyoku extract, Reynoutria sachalinensis extract, Uyaku extract, Pumpkin extract, Cattail

(Bulrush) extract, Kansui (sweet) extract, Agrimony japonica (Sentsuru grass) extract, Kuro-moji extract,

Micranthes fusio extract, sisal (sisal) extract, Chinese clematis extract, shi

Clematis extract, Clematis extract, Prunus speciosa extract, Oo

Yamazakura extract, Mamezakura extract, Takanezakura extract, Kohigan extract, Satozaku

La extract, Zion (Shien) extract, Palm extract, Shirobanairis extract, Clematis

(Daitate) extract, Anise magnolia extract, Saxifraga fortunei extract, Evening primrose extract, Toshi

Shi extract, Cuscuta australis extract, Dodders extract, Wormwood extract, Achillea millefolium extract

Tribulus extract, ringworm extract, dill extract, Japanese knotweed extract, Tribulus terrestris extract

Pyrrosia lingua (stone reed) extract, cattail (bulrush) extract, biakshi extract, floral bra 30

Nka extract, Hamula extract, Artemisia scoparia extract, Convolvulaceae extract, Sandalwood

Extract, Ganoderma lucidum extract, Leonurus japonicus extract, Gilgiana extract, Red

Meyanagi extract, pussy willow extract, salix integralist extract, kinuyanagi extract, koria

Nagi extract, Unryu willow extract, Miyama willow extract, Yamayanagi extract, Ooba

Willow extract, Willow extract, Willow extract, Populus maximowicz extract, Yama

Bayberry extract, agave mid-autumn, agave extract, fukurinri

Yuzetsuran extract, mitsumata extract, green laver extract, green laver extract, susia

Onori extract, Hira aonori extract, Bow aonori extract, Hosoeda aonori extract, co

Kombu extract, kelp extract, resilicon extract, hosomekombu extract, mitsushikon

Wakame extract, seaweed extract, undaria undario extract, seaweed extract, hijiki extract, rockweed extract 40

Aqaba, Umiuchiwa extract, Usubaumiuchiwa extract, Kirebanoumiuchiwa extract, Aqaba

Umiuchiwa extract, Konaumiuchiwa extract, Okinawauchiwa extract, Usuyukiuchiwa extract

, Etsuki sea urchin extract, thorn giraffe extract, eucheuma extract, giraffe

Rhinoceros extract, Juniper rhinoceros extract, Chondrus extract, Chondrus extract, Maru

Batsunomata extract, Hirakotoji extract, Suginori extract, Shikinori extract, Kainori extract

Extract, Yahazugusa extract, Uraboshiyahazu extract, Ishimozuku extract, Misujikonbu extract

Thing, Atsubamisujikonbu extract, Isomoku extract, Nagashimamoku extract, Shidamoku extract

, Nejimoku extract, Narasamo extract, Mametawara extract, Tatsukuri extract, Yatsumatamoku

Extract, Umitranoo extract, Oobamoku extract, Mukadenori extract, Nuraxa extract,

Chronulaxa extract, Scolopendridae extract, Matsunori extract, Scolopendridae extract, Ka 50

 (43) JP 2018-90631 A 2018.6.14

Imensou extract, Fushitsunagi extract, Himefushitsunagi extract, Hirohafushitsunagi extract

, Kurosozo extract, Kobusozo extract, Hanesozo extract, Sozonohana extract, Hakesaki mushroom

Gilihiba extract, Thira extract, Camote de azafran extract, Hamaika extract, Poleo

Verde extract, Nabonegro extract Fushijimoku extract, Hahakimoku extract, Yoremoku extract

Thing, Nokogirimoku extract, Ooba extract, Placenta extract, Rucinol, Silk extract, Red

Shea extract, acerola extract, velvetleaf (winter mallow) extract, fern liquor extract, quels

(Oak apple) Extract, Chestnut extract, Kameba hikiokoshi extract, Kurobana hikiokoshi extract,

Isodon japonicus extract, auction extract, buckwheat extract, darbilia extract, shepherd's purse extract

Things, Fujibakama (orchid grass) extract, mulberry extract, gardenia jasmine extract, angelica acutiloba extract, crackle

C. Extract, Clara extract, Mugwort extract, Honeysuckle extract, Phellodendron amur extract, Houttuynia cordata extract Ten

Hawthorn, pine root extract, adlay extract, dead-nettle extract, hop extract, hawthorn

Extract, eucalyptus extract, yarrow extract, altea extract, cinnamon extract

, Witch hazel extract, Hamamelis extract, Yamagwa extract, Kikyo extract, Yoriko extract,

Blackberry extract, Ephedra extract, Senkyu extract, Dokkatsu extract, Psycho extract, Siler

Extract, Glehnia extract, Ogon extract, Peony bark extract, Peony extract, Gen

Rhus chinensis extract, kakkonto extract, licorice extract, quintuplet extract, aloe extract, ginger extract

Gambir extract, safflower extract, green tea extract, black tea extract, Asenyaku extract, chamomile extract, indigo plant extract

Things, plant extracts such as oil-soluble licorice extract, Nishikawayanagi extract, Saxifraga stolon extract, Feni

Lumercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide, zinc peroxide

, 2-Aminophenol and its derivatives, ferulic acid and its derivatives, placenta extract 20

, Glutathione, oryzanol, butylresorcinol and the like can be exemplified.

[0087]

(Anti-inflammatory agent)

Further, as an anti-inflammatory agent that can be blended in the beauty essence of the present invention, solid dipropionic acid is used.

Metazone, clobetasol propionate, fluticasone propionate, hydrocortisone

-21-Propionate, Hydrocortisone Cyclopentyl Propionate, Dipropio

Propionic acid derivatives such as beclomethasone acid, allantoin, allantoin acetyl-

dl-Methionine, Allantoin Chlorhydroxyaluminum, Allantoin Dihydro

Allantoin such as xyaluminum and allantoin polygalacturonic acid or its derivatives

, Glycyrrhizic acid, glycyrrhizic acid, glycyrrhetinic acid allantoin, glycyrrhetinic acid 30

Glycerin acid acid, stearyl glycyrrhetinate, glycyrrhetinyl stearate, 3-sa

Disodium cusinyloxyglycyrrhetinate, dipotassium glycyrrhizinate, glycyrrhizin

Glycyrrhetin or its derivatives such as monoammonium lithate, pantothenic acid, punt

Tenyl alcohol, pantothenyl ethyl ether, benzoyl pantothenyl ethyl ether

Le, calcium pantothenate, sodium pantothenate, acetylpantothenylethyle

Pantothenic acids such as ether, benzoic acid pantothenyl ethyl ether ester, and pantetin

Derivatives of, α-tocopherol, β-tocopherol, γ-tocopherol, nicotinic acid

Tocopherol, tocopherol acetate, tocopherol linoleate, tocophere ferulate

Rolls, tocopherol derivatives such as tocopherol phosphate, tocotrienols

, Vitamin E acetate, tocopherol succinate and other vitamin E or its derivatives, 2 40

-Aminophenol and its derivatives, sulindac, diclofenac, fenbufen

Which acetic acid derivatives, pyridoxine hydrochloride, menthol, biotin, camphor, turpentine, acids

Zinc, Azulene, Guaiazulene and its derivatives, mefenamic acid and its derivatives, Fe

Namic acid and its derivatives, phenylbutazone and its derivatives, indomethacin and its induction

Body, ibuprofen and its derivatives, biphenylcarboxylic acid derivatives, oxycam, salichi

Acid, acetylsalicylic acid, naproxene, benoxaprofen, flurubiprofen,

Phenoprofen, Indianprofen, Pyrprofen, Calprofen, Oxaprodite

, Planoprofen, Microprofen, Thioxaprofen, Sprofen, Aluminum

Noprofen, tiaprofenic acid, fluprofen, ketoprofen and its derivatives, ε

-Aminocaproic acid, diclofenac sodium, diphenhydramine, tranexamic acid 50

 (44) JP 2018-90631 A 2018.6.14

And its derivatives, cortisone and its esters, hydrocortisone and its esters,

Adrenal cortex hormones such as redonison and prednisolone, antihistamines, bucroxic

Acid, Apazone, Bromphenak, Celecoxib, Diphenpyramid, Difluniser

Le, etodolac, flufenamic acid, ketorolac, meclophenamate, mephenamic acid

, Meloxicam, Nabumetone, Piroxicam, Butibfen, Rofecoxib, Tormethi

, Ketrolactromethamine, chlorpheniramine, diphenhydramine hydrochloride, Murray

Chlorpheniramine acid acid, corticosteroid, alchrometazone, dexamethazone, fu

Lumetazone, hydrocortisone, hydrocortisone-21-monoester, hydrocorti

Zon-21-acetate, hydrocortisone-21-butyrate, hydrocortisone-2

1-Valate, Hydrocortisone-17,21-Diester, Hydrocortisone-17 Ten

, 21-Diacetate, Hydrocortisone-17-Acetate-21-Burate, Hyd

Locortisone-17,21-dibutyrate, methylprednisolone, betametazo benzoate

, Difluorazone diacetate, fluoronide, mometazone flonate, topical corticoste

Lloyd, hydroxytriamcinolone, alpha-methyldexamethasone, dexamethasone

Phosphate, clobetasol propionate, desonide, desoximetasone, desoxycorti

Costerone acetate, dichlorasone, diflorasone diacetate, diflucortolone valerate,

Fluadrenolone, fluclorolone acetonide, fludrocortisone, pivalate full meta

Zon, fluocinolone acetonide, fluocortolone butyl ester, fluocortolone, vinegar

Acid fluprednidene (fluprednylidene), flulandrenolone, halcinonide, acetic acid

Hydrocortisone, hydrocortisone butyrate, triamcinolone acetonide, cortodoxo 20

, Flucetonide, Medrizon, Amsiafel, Amcinafide, Betamethasone, Kuro

Loprednisone, chloroprednisone acetate, crocorterone, cresinolone, diflupre

Donate, fluchloronide, flunizolide, fluoromethazone, fluperolone, flupre

Donizolone, hydrocortisone valerate, hydrocortisone, meprednisone, parameters

Zon, triamcinolone, isoxicam, tenoxicam, sudoxicam, CP-14,3

04, true aloe, plant sterol, phytosterol, indigo plant, assenyaku, amacha,

Artea, Arnica, Aloe, Ebutranoo, Irakusa, Agetsu, Echinashi, Enmei

Saw, turmeric, barley, barley, hypericum, orange, valeriana, hippopotamus, kami

Tsure, carrot, capillary wormwood, licorice, cucumber, honeysuckle, guggal

al), Gardenia jasmineides, Kumazasa, Watercress, Gentiana, Geranium thunbergii, Coke, Gobo 30

C, comfrey, comfrey, sesame seed extract, salvia, Japanese pepper, ciantro, shi

Kon, perilla, peony, birch, sage, St. John's wort, ivy,

Juniper, Yarrow, Peppermint, Swertia japonica, Swertia japonica, Swertia japonica

Hi, Taisou, Thyme, Chinese Parsley, Centella asiatica, Tougashi, Tounin, Houttuynia cordata

, Tormentilla, Tadeai, Cha, Angelica acutiloba, Calendula officinalis, Elderberry, Carrot, Pase

Li, mint, sandalwood, loquat, butcher bloom, grapes, broccoli, safflower

, Hoou, Bodaiju, Button, Mangista, Maronnier, Mukuroji, Muchigoat Extract, Mu

Rasaki Tsuyukusa, Mematsu Yoigusa, Peach, Yagurumasou, Eucalyptus, Yomogi, Youbaihi

, Lavender, Roman chamomile, rosemary and other plants or plant-derived extracts, etc.

Ingredients and mixtures thereof can be exemplified. 40

[0088]

In particular, in the case of a beauty essence containing the external composition for skin of the present invention, the greens derived from natural ingredients

Glycyrrhetin such as stearyl tilletate and dipotassium glycyrrhizinate or its inducement

Conductor, Gentiana extract, Perilla extract, Sage extract, Seiyouniwatoko extract, Tsuboku

Sa extract, Houttuynia cordata extract, Angelica acutiloba extract, Button extract, Evening primrose extract, Muku

Logi extract, Saxifraga stolon extract, mugwort extract, apple extract alone or more

It is desirable to use it as an anti-inflammatory agent in or in combination. Each of them is usually a book

0.0001% by mass or more, preferably 0.001 to 50% by mass, per mass of the beauty essence of the present invention.

%, More preferably 0.01 to 25% by mass, still more preferably 0.1 to 10% by mass.

Formulated in a range. 50
 (45) JP 2018-90631 A 2018.6.14

[089]

<Emulsion>

The external composition for skin of the present invention is based on an aqueous medium, and has an oily component and a surface activity.

A milky lotion can be obtained by blending the agent. The purpose of the emulsion is to cleanse and purify the skin.

It is used for removing cosmetics, protecting the skin, moisturizing and softening, and promoting blood circulation in the skin. Emulsion is a special place

It is also known as a fluid emulsion with a smaller amount of oil phase than cream except for the case.

Also called "liquid cream". There are both O / W type and W / O type emulsification types.

However, it is generally O / W type and has a large proportion of aqueous phase, so when applied to the skin, it stretches thinly.

Gives a moist feel. The oily component and surfactant are described in detail in the above section of lotion.

Each of the above-mentioned components can be used as appropriate. Ten

[0090]

The emulsion of the present invention further contains a moisturizing agent, an emollient agent, and a blood circulation promoting agent according to the purpose and function.

And one or more selected from high molecular weight substances can be blended, each of which

Usually, 0.0001% by mass or more, preferably 0.001 or more, per mass of the emulsion of the present invention.

50% by mass, more preferably 0.01 to 25% by mass, even more preferably 0.1 to 10

It is blended in the range of mass%. The moisturizer and emollient agent are described in detail in the section of the above-mentioned lotion.

Each of the above components can be appropriately blended. As a blood circulation promoter and a high molecular substance,

For example, the blood circulation promoter and the polymer substance described below can be appropriately blended.

[0091]

(Blood circulation promoter) 20

As blood circulation promoters, assembly, carrot (Otane carrot), ginkgo, Irakusa,

Ginger, garlic, Angelica keiskei, Arnica, apricot, fennel, enmeisou, otogi

Lisou, Ononis, Dutch Kashi, Karanashi, Kamitsure, Roman Kamitsure, Ki Strawberry, Ki

Na, Gubidinsou, Clara, Gentiana, Kay, Kohone, Gobo, Rice, Salvia, Sa

Nsho, Sanzashi, Shiitake, Jio, Shibugaki, Shakuyaku, Shokyo, Show

Hawthorn, horse chestnut, horse chestnut, juniper, senkyu, tie dye, thyme,

Chouji, Togarashi, Touki, Tokinsenka, Tounin, Tohi, Dokudami, Tosho

U, mint, witch hazel, witch hazel, butcher bloom, grapes, bodaiju, ho

P, Button, Pine, Maronnier, Mannenrou, Melissa, Merirot, Yuzu, Biwa, Yo

Quinin, lavender, lindow, rosemary, rosehip, cock, peach, walnut 30

, Horsetail, iris root, aloe, bayberry, eucalyptus, mugwort and other plant-derived substances

, Hesperidin, glycosylated hesperidin, rutin, glycosylated rutin, acetylcholine, calcium chloride

Lupronium, diphenhydramine hydrochloride, γ-oryzanol, l-menthol, cephala

Antin, Vitamin E, δ-tocopherol, α-tocopherol, tocopherol acetate,

Tocopherol linoleate, methyl nicotinate, tocopherol nicotinate, totosuccinate

Vitamin E derivatives such as copherol and vitamin E nicotinate, minoxidil, nicotine

Examples thereof include acid amide, nonyl acid vanillyl amide, and carbon dioxide gas.

[0092]

(Polymer substance)

In the case of emulsion, generally, a polymer substance is added to the aqueous phase in advance for the purpose of protective colloid. 40

In many cases, the polymer substances include carboxyvinyl polymer, xanthan gum, and lye.

Lilpolymer, sodium carboxymethyl cellulose (CMC) and the like can be mentioned.

[093]

<Cream>

The external composition for skin of the present invention is based on an aqueous medium, and has an oily component and a surface activity.

A cream can be obtained by blending the agent. The type of emulsification is the same as for emulsion

As shown above, although there are both O / W type and W / O type, cream generally has an oil phase amount compared to emulsion.

It is an emulsion with no fluidity due to the large amount of water. The purpose of the cream is similar to that of milky lotion.

It is for cleansing the skin, removing makeup, protecting the skin, moisturizing and softening, and promoting blood circulation in the skin. Yo

Specifically, cleansing cream, emollient cream, nourishing cream, na 50

 (46) JP 2018-90631 A 2018.6.14

It cream, base cream, vanishing cream, moisture cream, masser

Examples include di-cream, cold cream and lip balm.

[0094]

The oily ingredients and surfactants used in the cream are those described in the section on cosmetics.

These components can be used as appropriate. Also, in cream, as an auxiliary ingredient of oily ingredients,

Whale wax, cetanol, lanolin, liquid paraffin, petrolatum, glycerin and squalane

One or more selected from the above can be further blended, each of which is usually usually

0.0001% by mass or more, preferably 0.001 to 50% by mass, per mass of the cream of the present invention.

Mass%, more preferably 0.01 to 25% by mass, even more preferably 0.1 to 10% by mass

It is blended in the range of%. Ten

[0995]

<Other ingredients>

For the external composition for skin of the present invention, or for a lotion, a cleanser, a beauty essence, a milky lotion, or a cream.

In addition to the various components mentioned above, other components commonly used for these, such as the following

Thickeners, vitamins, amino acids, anti-wrinkle agents, seaweed extracts, cell activators, transdermal absorption

Accelerators, foaming agents, solubilizers, keratolytic agents, hormones, pigments, plasticizers, inorganic powders, organic powders

The powder and the like can be appropriately blended as needed.

[0906]

(Thickener)

Thickeners include guar gum, locust bean gum, queens seed, and carrageenan. 20

Tamarind, gum arabic, gum arabic, tamarind, gum karaya,

Abelmoschus manihot, cara gum, tragant gum, pectin, pectic acid, sodium salt, etc.

Salts, salts such as alginic acid and sodium salts, mannan, rice, corn, potatoes

, Starch such as wheat, dextrin, xanthan gum, dextran, succinogluca

Curdlan, hyaluronic acid and its salts, zansan gum, pullulan, gellan gum, ki

Chin, chitosan, agar, casso extract, chondroitin sulfate, casein, collagen

, Gelatin, albumin, methylcellulose, ethylcellulose, hydroxypropylse

Lurose, hydroxyethyl cellulose, carboxymethyl cellulose and its natriu

Salts such as mu, methyl hydroxypropyl cellulose, sodium cellulose sulfate, dialchi

Cellulose such as ledimethylammonium sulfate cellulose, crystalline cellulose, cellulose powder, etc. 30

And its derivatives, soluble starch, carboxymethyl starch, methylhydroxypropi

Starch-based polymers such as lestarch and methyl starch, hydroxypropyltrimoniu chloride

Starch derivatives such as starch, octenyl succinate corn starch aluminum

, Alginic acid derivatives such as propylene glycol alginate, polyvinylpyridone

(PVP), polyvinyl alcohol (PVA), vinyl pidridone and vinyl alcohol

Polymer, vinyl alcohol / vinyl acetate copolymer, polyvinyl methyl ether, polyethylene

Lenglycol, polypropylene glycol, polyoxyethylene / polyoxypropire

Copolymer, (methacryloyloxyethyl carboxybetaine / alkyl methacrylate

) Copolymer, (Acrylate / Stearyl Acrylate / Ethylamine Methacrylate Oki

Amphoteric methacrylate copolymers such as sid) copolymers, (dimethicone / vinyl dimethicone) 40

Con) Crosspolymer, (alkyl acrylate / diacetone acrylamide) copolymer

, (Alkylate acrylate / diacetone acrylamide) copolymer AMP, polyvinyl acetate

Partial saponified product, maleic anhydride copolymer, polyvinylpyrrolidone, vinylpyrrolidone meta

Dialkyl Crylate Aminoalkyl Copolymer; Acrylic Resin Alkanolamine, Polye

Polya such as steal, water-dispersible polyester, polyacrylamide, ethyl polyacrylate, etc.

Crylic acid ester copolymer, carboxyvinyl polymer, polyacrylic acid and its natri

Salts such as um salt, acrylic acid / methacrylic acid ester copolymer, acrylic acid / metaacry

Alkylation copolymer, cationized cellulose such as polyquaternium-10, polyquaternium

Dialyldimethylammonium chloride / acrylamide copolymer such as nium-7, poly

Acrylic acid / diallyldimethylammonium chloride copolymer such as quaternium-22, 50

 (47) JP 2018-90631 A 2018.6.14

Acrylic acid, diallyldimethylammonium chloride, ac, such as polyquaternium-39

Lilamide copolymer, acrylic acid / cationized metaacrylic acid ester copolymer, acrylic

Acrylic such as acid / cationized methacrylic acid amide copolymer and polyquaternium-47

Acid / methyl acrylate / methacrylamide propyltrimethylammonium chloride copolymer

, Chloride methacrylic acid ester polymer, cationized oligosaccharide, cationized dextran

Catified polysaccharides such as guar hydroxypropyltrimonium chloride, polyethyle

2-methacryloyloxye such as nimin, cationic polymer, polyquaternium-51, etc.

A copolymer of a chillphosphorylcholine polymer and a butyl methacrylate copolymer, etc.

Resin emulsion, ethyl polyacrylate emulsion, polyacrylic alkyl esthetic

Le Emulsion, Polyvinyl Acetate Resin Emulsion, Natural Rubber Latex, Synthetic Latec Ten

High molecular weight emulsions such as su, nitrocellulose, polyurethanes and various copolymers, various

Various silicone-based copolymers such as silicones and acrylic-silicone graft copolymers,

Various fluoropolymers, 12-hydroxystearic acid and its salts, palmitic acid dext

Dextrin fatty acid esters such as phosphorus and dextrin myristinate, hydroxysteari

Cholesteryl acidate, silicic anhydride, fumigant silica (ultrafine anhydrous silicic acid), alumini silicate

Magnesium ummagnesium, magnesium silicate, metal soap, metal dialkyl phosphate

, Bentnite, Hectrite, Organically modified clay minerals, Sucrose fatty acid esters, Flactoo

Rigo sugar fatty acid ester, malmero seed extract, hydroxyethyl guagam, carboxyme

Natural polymer substances such as tilgua gum, starch, carboxymethyl chitin, semi-synthetic polymer substances

Alternatively, a synthetic polymer substance can be exemplified. 20

[097]

(Vitamins)

Vitamins include retinol, retinol acetate, retinol palmitate, etc.

Tamine A and its derivatives, thiamine hydrochloride, thiamine sulfate, riboflavin, ribofu acetate

Rabin, pyridoxin hydrochloride, pyridoxin dioctanoate, pyridoxin dipalmite

To, flavin adenine dinucleotide, cyanocobalamine, folic acids, nicotinic acid amide

Nicotinic acids such as benzyl nicotinate, choliners, vitamin B6 hydrochloride, vitamin B6

Tripalmitate, Vitamin B6 Dioctanoate, Vitamin B12, Vitamin B2, Bi

Vitamin Bs such as Tamin B6, Vitamin B15 and their derivatives, α-tocopherols

Le, β-tocopherol, γ-tocopherol, tocopherol nicotinate, tokov acetate 30

Erol, tocopherol linoleate, tocopherol ferruate, tocopherol phosphorus

Tocopherol derivatives such as acid esters, tocotrienols, vitamin E acetate, co

Vitamin Es such as tocopherol succinate, vitamin Ds, vitamin H, pantothenic acid,

Flavonoids such as pantothenic acid, vitamin F, vitamin K, vitamin P and their derivatives,

Vitamin U, ferulic acid, γ-oryzanol, α-lipoic acid, ollotic acid, coenzyme Q

10. Biotin and the like can be exemplified.

[0998]

(Amino acids)

Amino acids include valine, leucine, isoleucine, treonine, methionine, and fu.

Enilalanine, tryptophan, lysine, glycine, alanin, asparagine, gluta 40

Min, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, ass

Paraginic acid, glutamate, hydroxylysine, arginine, ornithine, histidine,

Taurine, carnitine, etc. and their sulfates, phosphates, nitrates, citrates, or pi

Examples thereof include loridone carboxylic acid and derivatives thereof.

[00099]

(Anti-wrinkle agent)

Anti-wrinkle agents include glycerin, vitamin A or its derivatives, glycolic acid, acylation

Glucosamine, kinetin, vitamin E or its derivatives, aloe extract, collagen, hi

Peptides such as aluronic acid, tripeptide, tetrapeptide, seaweed extract, marronnier extract

Examples include a product, a rosemary extract, and a yagurumasou extract. 50

 (48) JP 2018-90631 A 2018.6.14

[0100]

(Seaweed extract)

Seaweed extracts include extracts from brown algae, red algae, green algae, indigo algae, etc.

Kombu, Kombu, Wakame seaweed, Hijiki, Gelidiaceae, Corallinoideae, Palmaria, Chondrus, Nori,

Aosa, Ana Aosa, Ascophyllum, Hibamata, Mozuku, Okinawa Mozuku, Himantari

Extracts from a and the like can be exemplified. This is also an extract from aquatic plants such as Amamo

include.

[0101]

(Cell activator)

Plants of whey, Arnica, Phellodendron amur, Chlorella, Hops, Suzuna, etc. as cell activators Ten

Extracts of substances, amino acids such as γ-aminobutyric acid and ε-aminoproic acid, retinol, chia

Vitamins such as min, riboflavin, pyridoxine hydrochloride, pantothenic acids, glycol

Α-Hydroxy acids such as acid and lactic acid, flavonoids, saponins, allantoin, photosensitizer 1

No. 01, Photosensitizer No. 301, Photosensitizer No. 401, NK-4 and the like can be exemplified.

[0102]

(Transdermal absorption promoter)

As a transdermal absorption promoter, α-hydroki such as urea, lactic acid, fruit acid, and glycolic acid

Β-Hydroxy acids such as silic acid and salicylic acid, oleic acid, undecanoic acid, octano

Le, nonanol, menthol, thymol, limonene, dimethyl sulfoxide, dodecylme

Chill sulfoxide, dimethylacetamide, N, N-dimethylformamide, lauryl sulfur 20

Sodium acid, N, N-bis (2 hydroxyethyl) oleylamine, polyoxyethyle

(20) Sorbitan monooleate, dodecyldimethylammoniopropanesulfonic acid,

Propylene glycol, polyethylene glycol, n, n-dimethyl-m-toluamide,

Diethyl-m-toluamide, laurocapram, 1-dodecylazacycloheptane-2-o

, Isopropyl millistate, isopropyl palmitate, N-mono or di-substitution-p-

Mentan-3-carboxyamide, 2- (2-methoxy-1-methylethyl) -5-methi

Lucyclohexanol, azacycloalkane derivative, cyclodextrin, etc. can be exemplified.

To.

[0103]

(Foaming agent) 30

As the foaming agent, azodicarbonamide, barium azodicarboxylate, azobis

Isobutyronitrile, azodicarboxylic acid amide, N, N'-dinitrosopentamethylenete

Tramin, N, N'-dimethyl-N, N'-dinitrosoterephthalamide, trinitroto

Limethyltriamine, 4,4'-oxybis (benzenesulfonyl hydrazide), parato

Ruensulfonyl hydrazide, diphenylsulfone-3,3'-disulfonylhydrazide

, Allylbis (sulfonyl hydrazide), p-toluylene sulfonyl semicarbazide, 4

, 4'-oxybis (benzenesulfonyl semicarbazide), trichloromonofluorome

Alkane fluorides such as tan and dichloromonofluoromethane, 5-morpholyl-1,2,3

， 4-Thiatriazole, ammonium carbonate, ammonium hydrogen carbonate, natriu hydrogen carbonate

Examples thereof include ammonium nitrate, ammonium nitrite, sodium borohydride, and azides. 40

[0104]

(Plasticizer)

As the solubilizer, ethanol, phenoxyethanol, isopropanol, butyla

Lucor, benzyl alcohol, lauryl alcohol, myristyl alcohol, cetyl alcohol

Lucor, setostearyl alcohol, stearyl alcohol, oleyl alcohol, beetle

Henyl alcohol, ethylene glycol, diethylene glycol, triethylene glycol

, Polyethylene glycol, propylene glycol, dipropylene glycol, polyp

Lopyrene glycol, glycerin, diglycerin, polyglycerin, monostearate

Lyserine, isoprene glycol, 1,2-butanediol, 1,3-butanediol,

1,4-Butanediol, 2,3-Butanediol, 1,2-Pentanediol, 1,5 50

 (49) JP 2018-90631 A 2018.6.14

-Pentanediol, 2,3-pentanediol, 2,4-pentanediol, sorbito

Lu, malbitol, raffinose, hexylene glycol, diethanolamine laurate

Mido, polyols such as fatty acid diethanolamide, polyoxyethylene alkylphenyl

Ether, polyoxyethylene alkyl ether, polyoxyethylenorail alcohol

Ether, polyoxyethylene polyhydric alcohol fatty acid ester, polyoxyethylene curing

Castor oil, polyhydric alcohol fatty acid ester, ethylene glycol fatty acid ester, polyg

Positives such as lycerin fatty acid ester, glyceride fatty acid ester, tetraalkylammonium salt, etc.

On-surfactant, alkyltrimethylammonium salt, alkylpyridinium chloride,

Stearyltrimethylammonium chloride, fatty acid salt, alkyl sulfate, alkyl A

Telsulfate ester salt, alkylsulfate triethanolamine, polyoxyethylene lauryl Ten

Yin of sodium sulphate, sodium lauryl sulphate, sodium lauroyl glutamate, etc.

On-surfactant, betaine type such as lauryldimethylaminoacetate betaine, sulfobetaine

Amphoteric surfactants such as type and sulfoamino acid type, polyether-modified silicone, amino-modified series

Silicone surfactants such as ricone, lecithin, lysophosphatidylcholine, cerami

Examples include natural surfactants such as de, celebroside, and sodium surfactin.

[0105]

(Keratin solubilizer)

As keratolytic agents, glycolic acid, tartaric acid, salicylic acid, citric acid, lactic acid, pyruvin

Acid, gluconic acid, glucuronic acid, malic acid, oxalic acid, malonic acid, succinic acid, acetic acid, fe

Noll, resorcin, retinoic acid, adaparene, trichloroacetic acid, 5-fluorourasi 20

Lu, azelaic acid, etc. can be exemplified, and as hormones, estradiol, es

Tron, ethinyl estradiol, cortisone, hydrocortisone, prednisolone,

Examples include cholecalciferol, estrogen, pregnenolone, and corticosteroids.

Wear.

[0106]

(Pigment)

Pigments include talc, kaolin, mica, sericite, calcium carbonate, and magne carbonate.

Constituent pigments such as sium, magnesium silicate, silicic anhydride, titanium oxide, zinc oxide, etc.

White pigment, yellow iron oxide, red iron oxide, black iron oxide, gunjo, konjo, chromium oxide, hydroxide

Colored pigments such as chromium chemicals and carbon black, fish scale foil, bismuth oxychloride, titanium mica 30

, Pearl pigments such as colored mica titanium, magnesium stearate, calcium and al

Minium salt, lauric acid, palmitic acid, zinc salt of myristic acid, starch powder, silk powder

-, Nylon powder, methyl polymethacrylate powder, polyethylene powder, and other powder pigments

It can be illustrated. As the plasticizing agent, dibutylphthalate, dioctylphthalate, que

Examples thereof include acetyltributyl acid acid, camphor and the like.

[0107]

(Inorganic powder)

Inorganic powders include calcium hydrogen phosphate, organically modified montmorillonite, silicic acid, and anhydrous.

Silica, magnesium silicate, mica, bentonite, titanium-coated mica, bisma oxychloride

S, zirconium oxide, magnesium oxide, zinc oxide, calcium carbonate, magnesium carbonate 40

, Iron oxide, ultramarine, dark blue, chromium oxide, calamine, zeolite, carbon black, etc.

Can be exemplified. In addition, as organic powder, polyamide, polyester, polyethylene, po.

Repropylene, polystyrene, polyurethane, vinyl resin, urea resin, phenol resin,

Fluorine resin, silicon resin, acrylic acid resin, melamine resin, epoxy resin, polycarbonate

It consists of two or more types of resin, divinylbenzene / styrene copolymer, and monomer of the above compound.

Examples thereof include copolymers and cellulose.

[0108]

(Other ingredients)

For the external composition for skin of the present invention, or for a lotion, a cleanser, a beauty essence, a milky lotion, or a cream.

In addition to the above, antibiotics, glycosylated glycyrrhizin, glycyrrhizin, alpenro 50

 (50) JP 2018-90631 A 2018.6.14

Rose extract, Crocus chrysantus extract, millet seed extract, pomegranate flower extract, a

Lupinia Katsumadai seed extract, Kurorappatake child body extract, Hoonoki extract, Nanno

Chloropsis extract, Terminaria verylica extract, Vibrio arginolytics fermented liquid,

Human oligopeptide, aureobasidium purulent culture solution, Aspergillus / chestnut astringent skin

Fermented extract, Alteromonas fermented extract, hydrolyzed yeast extract, yeast extract, yeast polysaccharide

, Rice fermented liquid, Thermus thermophilus culture, sake lees extract, saccharomyces / Ca culture

Things, saccharomyces / K culture, saccharomyces / Mg culture, saccharomyces / zinc culture

Nutrients, saccharomyces / sea salt culture, (saccharomyces / xylinum) / black tea culture, sa

Caccaromices / silicon culture, saccharomyces / germanium culture, saccharomyces

Levisiae extract, saccharomyces / selenium culture, saccharomyces / iron culture, sacca Ten

Lomises / Copper cultures, Saccharomyces culture lysates, Saccharomyces / manganese cultures,

Saccharomyces lysate extract, Pseudoalteromonas fermented extract, sclerothium gum

, Sphingomonas extract, fermented soybean extract, fermented soymilk, lactic acid bacillus / eriodiccio

Fermented Nkarihornikum extract, lactic acid bacterium / olive leaf fermented extract, lactic acid bacterium / cacao fruit

Fermented liquid, lactic acid bacterium / quinoa fermented extract, lactic acid bacterium / rice fermented extract, lactic acid bacterium / seiyo

Pear juice fermented liquid, lactic acid bacterium / soybean fermented extract, lactic acid bacterium / tomato fermented extract, lactic acid bacterium

/ Date palm fruit fermented extract, lactic acid bacterium / (milk / Ca / phosphorus / Mg / zinc) fermented product, lactic acid

Bacillus / hibiscus flower fermented liquid, lactic acid bacillus / (bean seed extract / sodium glutamate) fermentation

Liquid, lactic acid bacterium / grape juice fermented liquor, lactic acid bacterium / pepo pumpkin fruit fermented extract, lactic acid bacterium /

(Litchi extract / Shiitake extract) Fermented liquid, Lactic acid bacterium / Lemon peel fermented extract, Lactic acid bacterium 20

/ Wasabi root fermented extract, lactic acid bacterium culture solution, Bacillus / (rice bran extract / soybean extract)

Fermented liquid, Bacillus fermented product, Bifidobacterium fermented extract, Micrococcus lysate, Yogurt

Liquid, fermented lanera / soybean protein, wine extract, β-D-glucuronic acid, α-L-i

An acidic polysaccharide linked with a trisaccharide structure in which zulon acid and β-D-glucuronic acid are linked as a basic unit.

Gelatin-like substance derived from stinkhorn, sunflower bud extract, jackfruit (seed) extract

Longan extract, longan extract, paracress extract, Himeringo extract, filiso

Sinca extract, pelargonidin extract, kinetin, glycylproline, ethylhexylg

Lyserine, ethoxydiglycol, oleylglyceryl, gluconolactone, dicapril

Luether, dihydroxyacetone, panthenylethyl, hydroxyalkyl (C16-

18) Hydroxy dimer dilinoleyl ether, hydroxyalkyl (C12-14) 30

Hydroxy dimer dilinoleyl ethers, ethers such as methoxyethanol and keto

, Asiatic acid, aleurit acid, sodium ursolic acid, oleanolic acid, gua

Nidin hydrochloride, aluminum citrate, sodium citrate, diammonium citrate,

Tri-citrate (tetramethylhydroxypiperidinol), succinyl glycyrrhetinic acid

Sodium, dithioglycolic acid, dithioglycolic acid MEA, dithiodiglycolic acid di

Ammonium, sebacic acid, thioglycolic acid, thioglycolic acid MEA, thioglycol

Ammonium Ammonium Lactate, Thiollactate, Ammonium Thiolate

Mu, calcium propionate, sodium propionate, pentetic acid, pentatic acid 5 nato

Organic acids such as rium and madecasicic acid or salts thereof, aminomethylpropanol, aminome

Chillpropanediol, diisopropanolamine, cysteamine hydrochloride, tetrahydro 40

Amines such as xypropylethylenediamine, deoxyribonucleic acid (DNA), deoxy

Ribonucleic acid potassium salt, ribonucleic acid (RNA), ribonucleic acid sodium salt, almond protein

, Aspartame, adenosine monophosphate, disodium adenosine phosphate, alanyl gluta

Min, (arginine / lysine) polypeptide, undecilenoylphenylalanine, el

Gothioneine, oligopeptide-6, ornithine hydrochloride, hydrolyzed DNA, hydrolyzed RN

A, hydrolyzed almond protein, hydrolyzed actin, hydrolyzed elastin, hydrolyzed

Zein, hydrolyzed oat protein, hydrolyzed keratin, hydrolyzed yeast protein, hydrolyzed

Degraded rice protein, hydrolyzed conchiolin, hydrolyzed silk, hydrolyzed white vana lupine

Protein, hydrolyzed soy protein, hydrolyzed corn protein, hydrolyzed milk tampa

Hydrolyzed honey protein, hydrolyzed hazelnut protein, hydrolyzed jojobatan 50

 (51) JP 2018-90631 A 2018.6.14

Park, hydrolyzed vegetable protein, hydrolyzed royal jelly protein, crow wheat grain tamper

Ku, milk sugar protein, disodium guanylate, creatine, keratin, wheat gluten

, Wheat protein, sarcosine, citrulline, dipalmitoyl hydroxyproline, dipe

Petit-2, sericin, soybean protein, hexapeptide-2, hexapeptide-3, f

Xapeptide-9, Hexapeptide-10, Hexapeptide-11, Pentapeptide-3

, Proteins and nucleic acids such as whey protein, Cohenteam A, Styrains, Papain

, Proteas, bromelines, lipases, enzymes such as α-glucosidase, menton

Terpenes such as glycerin acetal, (C30-38 olefin / isop maleate)

Lopil / maleic acid) copolymer, (HDI / PPG / polycaprolactone) crosspoly

Mar, PEG-4, PEG-6, PEG-8, PEG-12, PEG-16, PEG-2 Ten

Polyethylene glycols such as 0, PEG-30, PEG-32, PEG-40, PP

Propylene oxide polymers such as G-3 and PPG-7 or derivatives thereof, (VA / crotonic acid)

/ Vinyl neodecanoate) copolymer, (VP / DMAPA acrylate) copolymer, (V

P / vinyl caprolactam / DMAPA acrylate) copolymer, (VP / methacrylua)

Mid / Vinylimidazole) copolymer, (acrylamide / Ammonium acrylate)

Copolymer, (acrylamide / acryloyldimethyltaurine sodium / acrylic acid

) Copolymer, (acrylamide / acryloyl dimethyl taurine sodium) copolima

-, (Sodium Acrylate / Acryloyl Dimethyl Taurine Sodium) Copolymer,

(Sodium Acrylic Acid / Acryloyl Dimethyl Taurine) Copolymer, (Acrylic Acid /

Acrylamide methyl propane sulfonic acid) copolymer, (acrylic acid / alcohol acrylate) 20

Kill (C10-30)) copolymer, (amide propyltrimonium acrylate chloride

/ Acrylic acid amide) copolymer, (alkyl acrylate / octylacrylamide)

Polymers, alkyl acrylate copolymers or derivatives thereof, (alkyl acrylate / di

Acetone Acrylamide / Amodimethicone) Copolymer AMP, (alkyl Acrylate /

Diacetone Acrylamide) Copolymer, (alkyl acrylate / diacetone acrylic acid

Mido) Copolymer AMP, (alkyl acrylate / diacetone acrylamide) copolyma

-AMPD, (hydroxyethyl acrylate / butyl acrylate / methoxye acrylate)

Chill) copolymer, (hydroxyethyl acrylate / methoxyethyl acrylate) copoly

Mar, (hydroxyethyl acrylate / sodium acryloyldimethyltaurine) copo

Rimmer, (Acrylate / Acrylamide) Copolymer, (Acrylate / Acrylic Acid A) 30

Lucil (C10-30)) Crosspolymer, (Acrylate / Alkylate Acrylate Steer)

Lil / Ethylamine Methacrylate Copolymer, (Acrylate / Acrylate)

Droxyalkyl) Copolymer, Acrylate Copolymer, Carbomer, (Ethylene / Pu

(Lopylene) copolymer, (ethylene / propylene / styrene) copolymer, (octylua)

Crylamide / hydroxypropyl acrylate / butylaminoethyl methacrylate) Copo

Rimmer, synthetic wax, hydrogenated C16-14 olefin polymer, (butylene / ethylene /

Styrene) copolymer, polyacrylamide, sodium polyacrylate, polyethylene

Isoterephthalate, polyoctanium-5, polyoctanium-6, polyoctanium

-7, Polyoctanium-11, Polyoctanium-16, Polyoctanium-22, Po

Polyoctaniums such as Lioctanium-28 and Polyoctanium-32, Polygluk 40

Lonic acid, polydecene, polypropylsilsesquioxane, polyglyceryl methacrylate,

Polymethacryloyl ethyl betaine, polymethacryloyl ethyl betaine, repagermani

Synthetic polymer compounds such as um, acetyl dipeptide-1 cetyl, acetyl tetrapeptide

-2, Acetyl Tetrapeptide-5, Acetyl Hexapeptide-1, Acetyl Hexapep

Tide-3, isoalkyl (C8-16) sodium lactoglobryl sulfonate succinate

, Etc., which can be generally used for external skin compositions such as cosmetics.

In addition to these, existing cosmetic raw materials can be further used. Tato

For example, "Commentary on the Second Edition of Cosmetic Ingredient Standards", edited by Japan Official Standards Association, Pharmaceutical Affairs Daily Co., Ltd., 198

Published in 4 years, "Standards for non-standard ingredients for cosmetics", supervised by Examination Division, Pharmaceutical Affairs Bureau, Ministry of Health and Welfare, Yakuji Nippo Co., Ltd.

Published in 1993, "Supplementary Standards for Non-Standards for Cosmetic Ingredients", Supervised by Examination Division, Pharmaceutical Affairs Bureau, Ministry of Health and Welfare, Stock 50
 (52) JP 2018-90631 A 2018.6.14

Yakuji Nippo Co., Ltd., published in 1993, "Permission Standards for Cosmetic Types", supervised by Examination Division, Pharmaceutical Affairs Bureau, Ministry of Health and Welfare

, Pharmaceutical Affairs Daily Co., Ltd., published in 1993, "Standards for ingredients by cosmetic type", Judgment of Pharmaceutical Affairs Bureau, Ministry of Health and Welfare

Supervised by the Inspection Division, Yakuji Nippo Co., Ltd., published in 1997, "Latest Cosmetic Science-Revised and Augmented II",

Japan Cosmetic Engineers Association, Yakuji Nippo Co., Ltd., published in 1992 and "Cosmetics Encyclopedia", Japanification

Cosmetic Engineers Association, Maruzen Co., Ltd., published in 2003, "Japan Cosmetic Ingredients Collection 2007", Japan

All the chemicals listed in the Cosmetic Industry Association, Yakuji Nippo Co., Ltd., published in 2007, etc.

Cosmetic raw materials can be used in appropriate combinations.

[0109]

C. Production method

The external composition for skin of the present invention, or a lotion, a facial cleanser, a beauty essence, a milky lotion, or a liquid containing the same. Ten

Basic cosmetics such as Ream are used in aqueous media as a base and L-ascorbi as an active ingredient.

Through the step of mixing one or more selected from acids, derivatives thereof, and salts thereof.

Manufactured. More specifically, L-ascor as an active ingredient in an aqueous medium as a base.

One or more selected from biacids, derivatives thereof, and salts thereof are mixed and dissolved.

After setting the pH of the solution to 3 to 11, more preferably 5 to 9, the desired product type

It should be contained in an appropriate process until the target product is completed according to the appropriate treatment method.

I. The method and order of blending each component and the timing of various treatments impair the effects of the present invention.

Unless otherwise specified, it is possible to adopt an appropriate method and order widely used in the field.

Wear.

[0110] 20

In particular, hydrous crystals or anhydrous crystals of ascorbic acid 2-glucoside-sodium salt are used.

The external composition for skin of the present invention, or a lotion, a cleanser, a beauty essence, a milky lotion, or a cream.

When manufacturing basic cosmetics such as, ascorbic acid 2-glucoside-sodium in advance

With a composition in which salt crystals and 2-glucoside anhydrous crystals of ascorbic acid are blended in an appropriate blending ratio.

By doing so, as in the case of using conventional ascorbic acid 2-glucoside anhydrous crystals.

The desired pH when dissolved in an aqueous medium without being separately neutralized with alkali is 3 to 11.

It can be adjusted to preferably 5 to 9. According to this manufacturing method,

Not only does the neutralization step using Lucari become unnecessary, but the salt concentration due to the addition of alkali and buffering agents

It is preferable because the increase in the amount can be reduced.

[0111] 30

The above-mentioned external composition for skin of the present invention, or a lotion, a facial cleanser, a beauty essence, a milky lotion, or youthful

In basic cosmetics such as cream, L-ascorbic acid, its derivatives, and their

The blending amount of one or more kinds selected from the salt is not particularly limited, and it depends on the purpose.

Although it is determined as appropriate, it is usually L-ascor in terms of solids (anhydrides) per product mass.

0.1% by mass to 90% by mass, preferably 0.5% by mass to 50% by mass, as biacid.

More preferably, it contains 1% by mass to 10% by mass, and more preferably 5 to 10% by mass.

It is preferable to set it.

[0112]

The external composition for skin of the present invention thus produced, or a lotion, a washing pigment, a beauty liquid, a milky lotion,

Alternatively, basic cosmetics such as creams contain L-ascorbic acid as an active ingredient and its induction. 40

Turnover as it contains one or more selected from the body and its salts

Improves, maintains or enhances the barrier function in the skin, and hyaluronic acid in the skin

Excellent anti-wrinkle, anti-wrinkle, anti-blemishes, anti-slack, etc. that maintains or enhances production

It has a good effect.

[0113]

Hereinafter, the present invention will be described in more detail based on experiments.

[0114]

<Experiment 1: Effect of 2-glucoside ascorbic acid on skin turnover>

As already described herein, the epidermis is composed of "stratum corneum (stratum corneum)", "granular layer", and "granular layer" from the outside.

It is composed of "stratum spinosum" and "basal layer", and epidermal cells born in the basal layer move outward in sequence. 50
 (53) JP 2018-90631 A 2018.6.14

It becomes the stratum corneum and eventually peels off. Such a series of cycles is generally

It is called turnover, and when turnover is delayed due to aging, the skin becomes loose and wrinkles.

, Causes skin troubles such as fine wrinkles. 2-glucos ascorbic acid

The following experiments were performed to investigate the effect of sid on turnover.

[0115]

<Experiment 1-1: Effect of ascorbic acid 2-glucoside on skin cell proliferation>

Normal human neonatal foreskin epidermal keratinocytes (sold by Kurabo Industries, hereinafter abbreviated as "NHEK cells")

, EpiLife medium containing cell growth additive (EDGS: EpiLife Defined Growth Suprement) (sold by Invitrogen, hereinafter referred to as ED).

The GS-containing EpiLife medium is abbreviated as "EpiLife medium". ) Suspended in 5 volumes Ten

% CO 2 In the presence, subculture was performed at 37 ° C. with 60-80% confluent.

After peeling and washing the cells, 7.5 × 10 in HuMedia-KB2 medium (sold by Kurabo Industries Ltd.) 3

After adjusting to cells / mL, collagen (sold by Nitta Gelatin, trade name "Cellmatori"

x Type IV ”) coated 24-well plate inoculated at 0.4 mL / well, 5

Volume% CO 2 In the presence, the cells were cultured for 1 day under the condition of 37 ° C. After removing the culture supernatant, hydrocol

HuMedia-KB2 medium with thizone and insulin (sold by Kurabo Industries, hereinafter, "KB"

2-HI medium (abbreviated as "2-HI medium"), ascorbic acid 2-glucoside anhydrous crystal-containing powder (trade name "

AA2G ”, Hayashihara Co., Ltd.) has a final concentration of 2-glucoside ascorbic acid of 0 to 90.

Add 0.6 mL / well of the solution dissolved to 0 μM, and add 5 volume% CO. 2 Existence

It was cultured under the condition of 37 ° C. for 4 days. 60 μL / 25 vol% glutalaldehyde solution 20

After adding wells to fix the cells, remove the supernatant, wash with water, and then add a methylene blue solution.

Nuclear staining was performed by adding 0.24 mL / well. After washing with water, add 0.53N hydrochloric acid 0.5 mL /

Add wells to extract dye, transfer 0.1 mL / well to 96-well plate, wave

Absorptivity at lengths 595 nm and 650 nm was measured. The resulting absorbance at a wavelength of 650 nm

The value obtained by subtracting the value of the absorbance at a wavelength of 595 nm from the value was used as an index of the cell proliferation rate. Ascol

The case of using KB2-HI medium containing no biacid 2-glucoside was used as a control, and in that case

The cell proliferation rate was relatively evaluated with the value as 100%. The results are shown in Table 1.

[0116]

[Table 1]
30

[0117]

As can be seen in Table 1, ascorbic acid 2-glucoside is strong against NHEK cells.

It shows a growth promoting effect, and its relative cell growth rate is 148% at 100 μM and 300 μM. 40

157%, 169% at 900 μM, to increase the concentration of ascorbic acid 2-glucoside

Therefore, it rose. The above results show that ascorbic acid 2-glucoside proliferates skin epidermal cells.

By promoting, it improves turnover in the skin and causes wrinkles, fine wrinkles and slack.

It shows that it can be reduced. By the way, ascorbic acid 2-glucoside was used in the experiment.

L-ascorbic acid is released by the enzyme present in the NHEK cells.

It can be said that the action is the action of L-ascorbic acid. The same applies to Experiment 1-2 below.

It is like.

[0118]

<Experiment 1-2: Expression of differentiation marker protein of ascorbic acid 2-glucoside in skin cells

Impact> 50
 (54) JP 2018-90631 A 2018.6.14

In recent years, involucrin and phyllagrin have attracted attention as differentiation marker proteins for epidermal cells.

It has been. In this experiment, ascorbic acid 2-glucoside produced these differentiation marker proteins.

The effect on the actual situation was investigated.

[0119]

Normal human neonatal capsule epidermis keratinized cells (NHEK cells) in EpiLife medium 2.5

× 10 5 After preparation to cells / mL, inject 1 mL / well into a 12-well plate, 5 volume% C

O 2 In the presence, it was cultured for 1 day under the condition of 37 ° C. After removing the culture supernatant, ascorbic acid 2-

Add 1 mL / well of medium to which glucoside was added to a final concentration of 300, 600 μM.

5, 5 volume% CO 2 In the presence, it was cultured for 2 days under the condition of 37 ° C. Ascorbic acid 2-

The same culture in a glucoside-free medium was used as a control. Asses of the same concentration Ten

Add 1 mL / well of medium containing 2-glucoside-sodium salt of corbic acid.

Then, the cells were further cultured under the same conditions for 3 days. After removing the culture supernatant, phosphate buffered saline (PBS)

), Then a buffer for cell extraction (protein inhibitor, 2w / v% SDS, 1 mM)

Dissolve the cells in 20 mM Tris hydrochloride buffer containing EDTA, pH 8.0) and ice for 20 minutes.

After the above reaction, the protein was extracted by ultrasonic crushing using a sonifier (manufactured by Branson).

Ta. The extract was centrifuged, the supernatant was collected, and a part thereof was used for protein quantification. 4 in the remaining supernatant

Double concentrated sample buffer (50 mM DTT, 40 w / v% glycerin, 0.02 w / v%

Bromphenol blue containing 250 mM Tris-hydrochloric acid buffer, pH 6.8) mixed in 1/3 amount

Then, the sample kept at 99 ° C. for 5 minutes was used as a sample for Western analysis. Amount of protein 2 in 1 lane

Charge to 0 μg and perform SDS-polyacrylamide gel electrophoresis by conventional method. 20

After that, the protein in the gel was transferred to a polyvinylidene fluoride (PVDF) membrane by a conventional method.

It was blocked by immersing it in Block Ace (manufactured by DS Pharma Biomedical). P

VDF membrane, anti-involucrin antibody or anti-filagulin antibody (sold by Santa Cruz)

50 mM TBS containing 10% by volume block ace (for sale) (50 containing 200 mM NaCl)

In mM Tris-HCl (pH 7.4)) buffer (hereinafter referred to as "TBS buffer")

Immersed in a 100-fold diluted solution at room temperature for 1 hour and then containing 0.05% by volume Tween 20

Excess antibody was removed by washing with 50 mM TBS buffer. HRP-labeled anti-PVDF membrane

Soaked in a mouse IgG rabbit polyclonal antibody (sold by DAKO) solution at room temperature for 2 hours.

Ta. The membrane is washed with 50 mM TBS buffer containing 0.05 volume% Tween 20 for 30 minutes.

Later, a commercially available Western blotting detection kit (GE Healthcare Biosaier) 30

Detected using the product name "ECL Prime Western Blotting Detension System" sold by NSS, and image analysis software ("ImageJ", N.

Image analysis was performed with open source software developed by IH. Α-chi as an internal standard

Using tubulin, the expression of each protein was corrected to the relative expression level to the expression of α-tubulin.

The expression levels (with 50% as the control) were compared. The results are shown in Table 2.

[0120]

[Table 2]

40

[0121]

As shown in Table 2, the differentiation marker protein depends on the concentration of ascorbic acid 2-glucoside.

The expression levels of both involucrin and phyllagrin, which are white substances, were enhanced. Results above

The action of 2-glucoside ascorbic acid promotes the differentiation of cutaneous epidermal cells.

Cosmetics containing ascorbic acid 2-glucoside have been shown to turn on the skin. 50
 (55) JP 2018-90631 A 2018.6.14

It shows that it is excellent in improving the bar.

[0122]

<Experiment 2: Anti-spot effect of ascorbic acid 2-glucoside>

For 16 female subjects (ages 37-55 years), pigmentation sites on the face (shi)

A cream with the following composition containing ascorbic acid 2-glucoside, with the test site as the test site)

Was applied twice a day (morning and evening) at a time of 2 g for 90 days. 45 days before applying cream

And on the 90th day, the color tone of the test site of each subject was changed to Panton Color Formula Guide 747.

Investigate using XR, and use a colorimeter CR-200 (manufactured by Minolta) to determine the brightness of the test site (

L * value) was measured respectively, and the average value of 16 persons was calculated. The results are shown in Table 3.

<Composition of test cream> Ten

<Phase A>

Ingredients (Mass part)

water 53.29

Carbomer 2w / v% solution 15.0

EDTA2 sodium 0.1

Glyceres-26 3.0

<Phase B>

Tri (capryl / capric acid) glyceryl 5.0

Alkyl benzoic acid (C12-15) 7.5

Cyclopentasiloxane, cyclohexasiloxane 3.0 20

Dimethicone 0.5

stearic acid 2.5

Glyceryl stearate 2.0

Cetearyl alcohol 1.75

<Phase C>

Triethanolamine Appropriate amount

<D phase>

Ascorbic acid 2-glucoside anhydrous crystal-containing powder 2.0

(Product name "AA2G", Hayashibara Sales Co., Ltd.)

<Phase E> 30

Propylene glycol 56% by volume, diazolidinyl urea 1.0

30% by volume, 11% by volume of methylparaben, propylparaben

3% by volume

[0123]

The components of phase A are mixed while being heated, and the components of phase B are also heated and mixed, and then phase B is added to phase A.

did. After adding the C phase to this and cooling it, and further adding the D phase and the E phase, triethanolamine

The pH was adjusted to 6.5 with min.

[0124]
[Table 3]
40

[0125]

As shown in Table 3, the L * value (brightness) of the test site increases and the color increases with the number of application days.

The color of the deposit site became lighter. Spots usually disappear over time, unlike sunburn

The above results show that ascorbic acid 2-glucoside is a pigmented site of the skin. 50
 (56) JP 2018-90631 A 2018.6.14

It is shown that it has the effect of lightening the color and improving the stain.

[0126]

<Experiment 3: Effect of 2-glucoside ascorbic acid on glutathione production (1)>

Glutathione is a peptide that functions as an antioxidant component and coenzyme in vivo, and is usually

Although it exists as an oxidized form, it exerts its function by being converted to a reduced form by an enzyme.

Volatilize. Therefore, it is desirable to increase glutathione levels in vivo, and glutathione

It is known that a decrease in the level of aging is one of the factors of aging. Ascorbic acid 2-gu

Experiments investigating the effect of lucoside on glutathione production in human epithelial-like cell cancer-derived cell lines

(A431 cell, Human Science Research Resource Bank, JCRB0004) (hereinafter, "

It is abbreviated as "A431 cell". ) Was used and the procedure was as follows. Ten

[0127]

<Test solution>

Dulbecco's MEM medium containing 10% by volume fetal bovine serum and antibiotics (hereinafter, "D-ME")

Abbreviated as "M medium". ), Ascorbic acid 2-glucoside (Hayashibara Co., Ltd., reagent grade)

) And L-ascorbic acid (sold by Wako Pure Chemical Industries, Ltd., special grade), ascorbic acid 2-

Dissolve so that the final concentration of glucoside or L-ascorbic acid is 1.0, 2.0 mM

The test solution was prepared.

<Method for quantifying the amount of glutathione produced in A431 cells>

A431 cells subcultured using D-MEM medium are collected and resuspended in D-MEM medium.

And on a 10 cm diameter cell culture plate, 1 x 10 6 Seed in cells / 10 ml / plate 20

It was cultured for 24 hours. Then, the culture solution is aspirated and removed, and any of the test solutions is added to 10 ml / play.

Was added and cultured for 24 hours. As a control, use only D-MEM medium at 10 ml / pump.

The rate was added and the cells were cultured for 24 hours. On each plate from which the culture supernatant has been removed, ice-cooled da

Add Rubeco PBS (-) (sold by Nissui Pharmaceutical Co., Ltd.) to wash the cells, and then screed.

Cells were harvested using par. Commercially available glutathione measurement kit (Biovision)

It was sold and measured using the trade name "Gluthatione Assay Kit").

Experiments were performed with 3 plates each for control or test solution, per plate.

The average amount of glutathione was calculated and used as the amount of glutathione produced. In addition, culture of A431 cells

In each case, a 5% by volume carbon dioxide gas culture device was used. Results are cultivated only in D-MEM medium

The reduced or total glutathione production of A431 cells when nourished is 100%, respectively. 30

Relative values were calculated and shown in Table 4.

[0128]
[Table 4]

40

[0129]

As shown in Table 4, in D-MEM medium supplemented with 1.0 mM L-ascorbic acid

Cell damage occurs and reduced glutathione and total glutathione in A431 cells are measured

I didn't come. Incidentally, L-ascorbic acid is added at a concentration that does not cause cell damage under the above conditions.

Total glutathione and reduced glutathione in A431 cells when 0.1 mM is added, which is the limit

The amount of production was 103% and 102%, respectively, which is about the same as the case without addition, and L-asco.

No increase in glutathione production due to rubic acid could be confirmed.

[0130]

On the other hand, 1.0 mM or 2 ascorbic acid 2-glucoside in D-MEM medium. 50

 (57) JP 2018-90631 A 2018.6.14

.. In the case of A431 cells cultured in a medium supplemented with 0 mM, total cells were not damaged.

Glutathion production increased to 115% and 508%, respectively, and 2-gu ascorbic acid.

Increased total glutathione production was observed depending on the amount of lucoside added. Also, reduced guru

The amount of tathione produced was 313% and 6816%, respectively, and ascorbic acid 2-glucoside.

Enhancement of reduced glutathione production was observed depending on the amount of addition. In addition, total glutathione

The degree of increase in reduced glutathione was large with respect to the increase in glutathione.

It shows that the reduced glutathione level is increasing. In the case of A431 cells

L-ascorbic acid to the extent that it does not cause cell damage from 2-glucoside ascorbic acid

Is released and is thought to exert an effect of enhancing glutathione production.

[0131] Ten

<Experiment 4: Effect of 2-glucoside ascorbic acid on glutathione production (2)>

Normal experiment to investigate the effect of ascorbic acid 2-glucoside on glutathione production

Human neonatal epidermal keratinized cells (NHEK cells, Kurabo) (hereinafter abbreviated as "NHEK cells")

To. ) Was used and the procedure was as follows.

<Test solution>

Ascorbic acid 2-glucoside (Co., Ltd.) was added to the EpiLife medium used in Experiment 1-1.

Hayashihara sales, reagent grade) and L-ascorbic acid (Wako Pure Chemical Industries, Ltd. sales, special grade)

The final concentration of scorbic acid 2-glucoside or L-ascorbic acid is 0.5, 1.0, 2.

A test solution was prepared by dissolving the mixture so as to be 0 mM.

<Method for quantifying glutathione production in NHEK cells> 20

NHEK cells subcultured using EpiLife medium are collected and used as EpiLife medium.

Resuspended in 1x10 on a 10 cm diameter cell culture plate 6 In cells / 10 ml / plate

It was sown and cultured for 24 hours. Then, the culture solution is removed by suction, and any of the test solutions is added to 10 ml /

The plate was added and the cells were cultured for 24 hours. As a control, only EpiLife medium, 1

0 ml / plate was added, and the cells were cultured for 24 hours. On each plate from which the culture supernatant has been removed,

After washing the cells by adding ice-cooled Dalveco PBS (-) (sold by Nissui Pharmaceutical Co., Ltd.)

, Cells were harvested using a scraper. Commercially available glutathione measurement kit (Bio vi)

Sold by sion, using the product name "Gluthatione Assay Kit")

It was measured. The experiment was performed using 3 plates for each control or test solution, and each pre

The amount of glutathione per ton and its average were calculated and used as the amount of glutathione produced. In addition, N 30

In each case, a 5% by volume carbon dioxide gas culture device was used for culturing HEK cells. The result is Ep

The reduced or total glutathione amount of NHEK cells when cultured only in iLife medium.

Relative values were calculated as 100% for each, and are shown in Table 5.

[0132]
[Table 5]

40

[0133]

As shown in Table 5, EpiLife medium supplemented with 0.5 mM L-ascorbic acid

Cell damage occurs, and reduced glutathione and total glutathione in NHEK cells are measured.

I couldn't decide. By the way, L-ascorbic acid has a concentration that does not cause cell damage under the above conditions.

When 0.1 mM is added, which is the upper limit, total glutathione and reduced glutathione in NHEK cells

The on-production amount was 103% and 102%, respectively, which was about the same as the case without addition, and L-as 50
 (58) JP 2018-90631 A 2018.6.14

No increase in glutathione production due to corbic acid could be confirmed.

[0134]

On the other hand, 0.5 and 1.0 of ascorbic acid 2-glucoside in EpiLife medium.

Total glutathione in the case of NHEK cells cultured in a medium supplemented with mM or 2.0 mM

The production amounts were 106%, 111% and 117%, respectively, and ascorbic acid 2-glucoside.

Increased total glutathione production was observed depending on the amount of. Also, EpiLife medium

In a medium containing 0.5, 1.0 mM or 2.0 mM of ascorbic acid 2-glucoside.

In the case of cultured NHEK cells, the amount of reduced glutathione produced was 106% and 11 respectively.

Ascorbin was 1% and 117%, depending on the amount of ascorbic acid 2-glucoside added.

Enhancement of reduced glutathione production by acid 2-glucoside was observed. Reduced guru Ten

The degree of increase in tathione is similar to that of total glutathione, which means reduced glutathione.

It shows that total glutathione production is increased without decreasing on-level.

.. Ascorbin in the case of NHEK cells as in the case of A431 cells in Experiment 3

L-ascorbic acid is released from acid 2-glucoside to the extent that it does not cause cytotoxicity.

It is considered to exert the effect of enhancing the production of glutathione.

[0135]

The results of Experiments 3 and 4 show that ascorbic acid 2-glucoside produces total glutathione and

It shows that it has a remarkable effect of enhancing reduced glutathione production, and ascor

Biano 2-glucoside is a total glutathione production enhancer or reduced glutathione production

It can be used as a life enhancer, and it is shown that aging of the living body can be suppressed through this action. 20

Instigating.

[0136].

<Experiment 5: Effect of 2-glucoside ascorbic acid on Dickkopf-1 production>

Suppresses the production and accumulation of melanin, a protein present in human skin that causes age spots

Dickkopf-1 (hereinafter abbreviated as "DKK1"), which is known to have an action to

An experiment to investigate the effect of ascorbic acid 2-glucoside on production (described) was conducted from DKK1.

Using NHDF cells (sold by Kurabo Industries Ltd.), which are normal human skin fibroblasts with viability,

It was done as follows.

<Effect of ascorbic acid 2-glucoside on DKK1 production in NHDF cells>

Cell concentration 1x10 on a 96-well plate 4 NHD diluted with culture medium so as to be individual / hole 30

F cells were seeded. Twenty-four hours after sowing, the supernatant in each well of the plate was removed.

Scorbic acid 2-glucoside to a final concentration of 0.5, 1, 2, 4 or 8 mM

It was added to the gel. As a control, a system to which ascorbic acid 2-glucoside was not added was provided.

After adding ascorbic acid 2-glucoside, each well of the 96-well plate on the 1st and 3rd days of culture

DKK1 in the supernatant is collected from ELISA for DKK1 measurement (trade name "RayBio"

], Quantified (n = 3) by Ray Biotech). Statistical analysis of measured values is a t-test

(T-test) ("Basic Statistics III Statistics of Natural Sciences", University of Tokyo Press

Published by the Society, p. 187 (2008)). The results are shown in Table 6.

[0137]
 (59) JP 2018-90631 A 2018.6.14

[Table 6]

Ten

[0138]

As shown in Table 6, ascorbic acid 2-glucoside is a concentration-dependent NHDF cell.

DKK1 production from DKK1 was significantly promoted, and DKK1 production on the 1st and 3rd days of culture.

Due to the amount of raw material, DKK1 production was significantly promoted in a culture time-dependent manner. 20

[0139]

From the results of this experiment, 2-glucoside ascorbic acid was administered to the living body to DK.

Promotes K1 production, thereby suppressing melanin production of melanocytes, keratinocytes

It is thought that it suppresses the transport of melanosomes to and has anti-spot and whitening effects. Also, ass

Corbic acid 2-glucoside is L-ascorbic acid and D-glue by the action of enzymes in the body.

L-ascoric acid is hydrolyzed into a course and exhibits the original function of L-ascorbic acid.

Derivatives of L-ascorbic acid other than ascorbic acid 2-glucoside as well as rubic acid

, L-ascorbic acid salt, and L-ascorbic acid derivative salt should also be administered to the living body.

Promotes the production of DKK1 and thereby suppresses the production of melanin in melanocytes.

It is thought that it suppresses the transport of melanosomes to latinosites and has anti-staining and whitening effects. 30

Is done. In particular, the crystals of ascorbic acid 2-glucoside and its sodium salt are L-ascor.

It is more stable than biacid and liberates L-ascorbic acid in vivo, and L-ascor

Since the original function of binic acid is exhibited, it is the most important ingredient for promoting DKK1 production.

It can be preferably used.

[0140]

<Experiment 6: Effect of ascorbic acid 2-glucoside on activation of small eyeball disease-related transcription factors

Microphthalmia-associated tr

Anscript factor (hereinafter abbreviated as "MITF") is an obese cell.

, A protein specifically expressed in osteoclasts, pigment cells and myocardial cells, and to be phosphorylated 40

Involved in the expression of various proteins involved in melanocytes and allergic diseases

ing. By suppressing the activation of MITF, allergic diseases and melanocyte proliferation are different.

It suppresses normality, and can be expected to suppress rough skin and whiten the skin. MI of ascorbic acid 2-glucoside

Experiments to investigate the effect of TF activation on mouse melanoma cell line B16 cells (hereinafter referred to as "

Abbreviated as "B16 cell". ) Was used and the procedure was as follows.

<Test solution>

Dulbecco's MEM medium containing 10% by volume fetal bovine serum and antibiotics (hereinafter, "D-ME")

Abbreviated as "M medium". ), Ascorbic acid 2-glucoside (Hayashibara Co., Ltd., reagent grade)

) And L-ascorbic acid (sold by Wako Pure Chemical Industries, Ltd., special grade), ascorbic acid 2-

Dissolve to a final concentration of glucoside or L-ascorbic acid of 2.0 or 8.0 mM 50

 (60) JP 2018-90631 A 2018.6.14

The test solution was prepared.

<Method for quantifying the amount of MITF produced in B16 cells>

B16 cells subcultured in D-MEM medium were collected and resuspended in D-MEM medium.

, 1x10 on a 6-hole plate 5 Seeded in cells / 2 ml / well and cultured for 24 hours. That

After that, the culture solution is removed by suction, 2 ml / well of any of the test solutions is added, and the culture is carried out for 2 hours.

Ta. As a control, only D-MEM medium was added at 2 ml / plate and cultured for 2 hours.

Ta. Ice-cooled Dulbecco PBS (-) on each plate from which the culture supernatant was removed (Nissui Pharmaceutical Co., Ltd.)

After washing the cells by adding (sold by the company), 62.5 mM Tris-HCl pH 6.8

, 2w / v% SDS, 10w / v% glycerol, 50 mM DTT, 0.01w / v%

Add 0.1 ml / well of SDS sample buffer containing bromophenol blue Ten

Then, the cells were collected with a scraper. This cell fluid is crushed by an ultrasonic crusher (Osmics)

), Then SDS polyacrylamide gel electrophoresis was performed. Electricity on the nitrocellulose film

After transcription, the primary antibody (Antiphospho-MITF (Ser473), also

Anti-MITF), react with secondary antibody, react with LumiGLO, and then X-ray

The worm was exposed and a MITF positive band was detected. Scion the obtained band intensity analysis

Image was used to determine the amounts of phosphorylated MITF and MITF. B1

In each case, a 5-volume% carbon dioxide gas culture device was used for culturing 6 cells. Cultivate with each test solution

Phosphorized MITF and MI when the amount of β-actin in B16 cells is 100%

The relative amount of TF and the phosphorylated MITF / MITF ratio were determined. The results are shown in Table 7.

[0141] 20
[Table 7]

[0142] 30

As shown in Table 7, in D-MEM medium supplemented with 2.0 mM L-ascorbic acid

Due to cell damage, the amount of MITF in B16 cells could not be measured. In addition, control (ass

In B16 cells when cultured in D-MEM medium without corbic acid 2-glucoside)

The phosphorylated MITF / MITF was 0.90.

[0143]

On the other hand, 2.0 or 8.0 m of ascorbic acid 2-glucoside in D-MEM medium.

In B16 cells cultured in the medium added with M, the phosphorylated MITF / MITF ratio was each.

These are 0.60 and 0.36, respectively, and MI depends on the amount of ascorbic acid 2-glucoside added.

Suppression of phosphorylation of TF was observed. The results of these experiments are ascorbic acid 2-glucosi

It shows that do has a remarkable effect of suppressing the phosphorylation of MITF, and ascor 40

Skin 2-glucoside by suppressing the activation of MITF by phosphorylation

It suggests that it works for roughness control and whitening.

[0144]

<Experiment 7: Cornified envelope of the stratum corneum with 2-glucoside ascorbic acid

(CE) production and proteins related to tight junction (TJ), which is an intercellular adhesion structure

Effect on production of

CE, which exists in the outermost layer of keratinocytes and is known to protect the inside of keratinocytes, and epidermis

TJ-related protein that exists in the granular layer and is known as an intercellular adhesion structure (hereinafter, "TJ")

Related protein ". ) Holds the key to the formation of barrier function in the skin (bi)

"Molecular and Cellular End" such as Kuru Di Di (Bikle DD) 50

 (61) JP 2018-90631 A 2018.6.14

Molecule and Cellular Endocrinolology, Vol. 177, pp. 161-171, 2001; Takuo

Yuki), etc., "Experimental Dermatology (Experimental)

Dermatology) ”, Vol. 16, pp. 324-330, 2007)

In view, in this experiment, ascorbic acid 2-glucoside is associated with these CE and TJ at the cellular level.

The effect on protein production was investigated. In addition, in each of the cited references, Karshiu

Mu (Ca) enhances the production of CE and TJ-related proteins and enhances the barrier function in the skin.

It is stated to do.

[0145]

<Experiment 7-1: Effect of 2-glucoside ascorbic acid on CE production in the stratum corneum> Ten

To investigate the effect of ascorbic acid 2-glucoside on CE production in the stratum corneum

, The following experiments were conducted. That is, as a model of standard normal human epidermal cells, normal human new

Live infant foreskin epidermal keratinocytes (sold by Kurabo Industries, hereinafter abbreviated as "NHEK cells") are Ep.

iLife medium (sold by Invitrogen, hereinafter referred to as "EpiLife medium".

) (PH 7.4) and cell concentration 1 × 10 on a 12-well microplate 5 Cells / holes

Seed so as to 5% by volume CO 2 Ascorbi after culturing overnight in the presence at 37 ° C.

Acid 2-glucoside anhydrous crystal-containing powder (trade name "AA2G", sold by Hayashihara Co., Ltd.)

Final concentration of corbic acid 2-glucoside is 0.5 or 1 mM, or CaCl as a positive control

2 Was added to each well so that the final concentration was 1 mM, and the medium of each well was added every two days.
Constant concentration of ascorbic acid 2-glucoside or CaCl 2 Fresh EpiLife medium containing 20

While exchanging with, 5 volume% CO 2 In the presence, it was cultured under the condition of 37 ° C. for 5 days. Including intracellular CE

The amount is measured by "Lipids" such as Tatsuya Hasegawa.

, Vol. 46, pp. 529-535, 2011. That is, after the culture is completed

Immediately remove the culture supernatant from each well and contain 2 w / v% sodium dodecyl sulfate (SDS)

Cells attached to the vessel wall of each well using phosphate buffered saline (PBS) (pH 7.4)

After cell extraction while peeling by pipetting operation, centrifugation (15,000r)

The insoluble fraction was recovered by pm × 10 minutes). SDS and 1,4-

Dithiothratel (DTT) so that the final concentrations are 2 w / v% and 20 mM, respectively.

After addition, boil for 2 hours to dissolve the insoluble fraction, sample, and the protein concentration is 1 m.

Adjust to g / ml and measure the optical density (OD) at a wavelength of 310 nm with a spectrophotometer. 30

And the measured value was taken as the CE production amount. As a control, ascorbic acid 2-glucosi

A system for culturing was provided in the same manner as described above except that the mixture was not added. The results are shown in Table 8.

[0146]
[Table 8]

40

[0147]

As shown in Table 8, ascorbic acid 2-glucoside is a positive control CaCl. 2 Same as

It was found that it has the ability to induce CE production in epidermal keratinized cells. Also, Ascol

It was also found that 2-glucoside binoic acid increases CE production in a concentration-dependent manner.

[0148] 50
 (62) JP 2018-90631 A 2018.6.14

According to the results of this experiment, 2-glucoside ascorbic acid has a barrier function in the skin.

It can effectively induce CE production in the stratum corneum, which plays an important role in

, It is considered that the barrier function in the skin, which decreases with age, can be maintained or enhanced.

available.

[0149]

<Experiment 7-2: TJ-related protein in which 2-glucoside ascorbic acid constitutes an intercellular adhesion structure

Effect on white matter production>

Ascorbic acid 2-glucoside produces TJ-related proteins that make up the intercellular adhesion structure

TJ, which is known to be present in the epidermal granular layer, for the purpose of investigating its effect on

As related proteins, occludin and ZO-1 have been in the limelight in recent years. Ten

The following experiments were conducted with a focus on. That is, as a model of standard normal human epidermal cells, N

HEK cells are suspended in EpiLife medium (pH 7.4) and finely divided into 12-well microplates.

Spore concentration 1 × 10 5 Seed to form cells / holes, 5% by volume CO 2 In the presence, under the condition of 37 ° C

After culturing overnight in, powder containing ascorbic acid 2-glucoside anhydrous crystals (trade name "AA2G")

, Hayashihara Sales Co., Ltd.), the final concentration of ascorbic acid 2-glucoside is 0.5 or 1 mM,

Or CaCl as a positive control 2 Was added to each well so that the final concentration was 0.5 mM.

5, 5 volume% CO 2 In the presence, it was cultured under the condition of 37 ° C. for 3 days. After culturing, 1 w / v% S

Using DS-containing PBS, the cells attached to the vessel wall of each well are peeled off by pipetting operation.

While doing so, cell extraction was performed. 20 μg protein per lane for cell extract in each well

20 mM DTT containing 10 w / v% sodium dodecyl sulfate-polyacrylic paint 20

For midgel electrophoresis (SDS-PAGE), as a primary antibody, anti-occludin mouse

Noclonal antibody (trade name "F-11", sold by Santa Cruz) or anti-ZO-1

Mouse monoclonal antibody (trade name "ZO1-1A12", sold by Invitrogen)

) As a secondary antibody, Western wasabi peroxidase (HRPO) -labeled anti-mouse Ig

G (trade name "P0447", sold by DAKO) or HRPO labeled anti-rabbit IgG (trade name)

Using "P0448", sold by DAKO), applying a known Western blot method, each

Premi with α-tubulin as the internal standard for the concentration of occludin or ZO-1 in the cell extract

The measurement was performed using a chemical luminescence detection reagent (trade name "Luminata Western HRP Subrates", sold by Merck).

The results are shown in Table 9. In Table 9,

Numbers with%,% are CaCl as a positive control 2 Ok in the cell extract in the addition system of 30

It represents a relative value when the rugin concentration and the ZO-1 concentration are each 100%.

[0150]
[Table 9]

40

[0151]

As shown in Table 9, ascorbic acid 2-glucoside is a positive control CaCl. 2 Same as

It was found that it has the ability to induce the production of occludin and ZO-1 in epidermal keratinocytes.

did. In addition, ascorbic acid 2-glucoside is produced in occludin and ZO-1 in a concentration-dependent manner.

It was also found to increase raw material.

[0152]

According to the results of this experiment, 2-glucoside ascorbic acid has a barrier function in the skin. 50
 (63) JP 2018-90631 A 2018.6.14

Ocludin, a TJ-related protein in the epidermal granule layer, which plays an important role in

The production of ZO-1 can be effectively induced, which results in age-related decline in the skin.

It is considered that the rear function can be maintained or enhanced.

[0153]

<Experiment 8: Effect of 2-glucoside ascorbic acid on hyaluronic acid production>

When hyaluronic acid in the dermis decreases with aging, wrinkles are formed and skin elasticity

In view of the fact that it is said that sexuality decreases and loosening and rough skin occur, in this experiment, ascorbi

The effect of acid 2-glucoside on hyaluronic acid production in the skin was investigated.

[0154]

That is, "Moisturizing / Whitening / Anti-wrinkle / Antioxidant Evaluation / Experimental Method Manual", edited and supervised by: Positive Ten

Kijin, published by Fragrance Journal, pp. 94-97, 2012

NHE as a model of standard normal human epidermal cells according to "Aluronic acid synthesis promotion evaluation method"

K cells were suspended in EpiLife medium (sold by Invitrogen) (pH 7.4).

Cell concentration 5 × 10 on a 12-hole microplate 4 Seed to form cells / holes, 5% by volume C

O 2 After culturing overnight in the presence of 37 ° C., the medium is cultivated with fresh HuMedia-KG2.

Ascorbic acid 2-glucoside anhydrous crystal-containing powder (commodity) in exchange for ground (sold by Kurabo Industries)

Name "AA2G", sold by Hayashihara Co., Ltd.) The final concentration of ascorbic acid 2-glucoside is 0.2

Add to each well to 5, 0.5 or 1 mM, 5% CO 2 In the presence of 37 ° C

It was cultured under the conditions for 3 days. Immediately after the completion of culturing, the culture supernatant of each well is collected, and the hime in the supernatant is collected.

Aluronic acid is used as a commercially available enzyme immunoassay (ELISA) kit (trade name "Hyalurona"). 20

n, DuoSet Kit ”, product code: DY3614, sold by R & D)

did. As a control, as described above, except that ascorbic acid 2-glucoside is not added.

A system for culturing was provided in the same manner as in the above. The results are shown in Table 10.

[0155]
[Table 10]

30

[0156] 40

As shown in Table 10, ascorbic acid 2-glucoside is used in epidermal keratinized cells.

It was found that it induces the production of aluronic acid and also induces it in a concentration-dependent manner.

[0157]

According to the results of this experiment, 2-glucoside ascorbic acid is involved in moisturizing the skin.

Can effectively induce the production of aluronic acid, which in the skin declines with age

Maintains or enhances the amount of hyaluronic acid, prevents or improves dry skin, and causes fine wrinkles due to dryness

It is thought that life can be suppressed, improved or made inconspicuous.

[0158]

<Experiment 9: Anti-wrinkle test of 2-glucoside ascorbic acid (1)>

A cream containing ascorbic acid 2-glucoside is used to improve wrinkles on the skin. 50
 (64) JP 2018-90631 A 2018.6.14

A volunteer test was conducted to find out. That is, 37 to 5 suffering from wrinkles on the face

16 5-year-old women were selected as subjects, and Ascorbic acid 2-glucoside, Asco

Rubic acid 2-glucoside anhydrous crystal-containing powder (trade name "AA2G", sold by Hayashibara Co., Ltd.)

Use, 1 g of the test cream with the following composition containing 2% by mass of this, after washing the face in the morning and in the evening

It was applied around the left and right eyes twice a day for 90 days after bathing. In addition, test clay

Mu was kept applied to the skin as much as possible during the test period. Tested during the test period

People spend their normal daily life except avoiding the use of cosmetics that claim to improve wrinkles.

I instructed him to do so. At the start of the test (day 0), during the test (day 45), and after the test ends (90)

On the day), the depth of wrinkles was measured from the skin surface shape by the following method, and the average value was calculated.

Is shown in Table 11. Ten

<Three-dimensional measurement of skin surface shape wrinkles>

At the start of the test (day 0), during the test (day 45), and after the test (day 90), both eyes

Replica creation kit for reflection ABS-01-W (Asahibai Co., Ltd.) with the butt as the test site

A skin replica was collected using (Omed). Replica analysis system for reflection ASA-

Analyzing the surface shape of the replica using 03R (manufactured by Asahi Biomed Co., Ltd.)

The wrinkled portion was identified by the above method, and the average depth of wrinkles from the reference plane at the test site was determined.

[0159]

<Test cream>

(Combined prescription)

Ingredients (mass%) 20

(1) Dimethicon 0.3

(2) Squalan 2.0

(3) Cetearyl isononanoate 1.0

(4) Triethylhexanoin 2.0

(5) Octildodecanol 2.0

(6) Fatty acid (C-10-30) (cholesteryl / lanosteryl) 3.0

(7) Polyglyceryl myristate-10 3.5

(8) Cetanol 3.5

(9) Bacil alcohol 1.0

(10) Cetyl palmitate 2.05 30

(11) Glyceryl stearate SE 2.5

(12) Batyl stearate 2.5

(13) 1,3-butylene glycol 3.0

(14) Methylparaben 0.2

(15) Glycerin 4.5

(16) Silap containing a sugar derivative of trehalose 2.0

(Hayashihara Sales Co., Ltd., product name "Tornale")

(17) Ascorbic acid 2-glucoside anhydrous crystal-containing powder 2.0

(Product name "AA2G", Hayashibara Sales Co., Ltd.)

(18) Citric acid Appropriate amount 40

(19) Sodium citrate Appropriate amount

(20) Potassium hydroxide Appropriate amount

(21) Purified water Appropriate amount

[0160]
 (65) JP 2018-90631 A 2018.6.14

[Table 11]

[0161]

Apply a cream containing ascorbic acid 2-glucoside as shown in Table 11. Ten

Then, the depth of wrinkles decreased according to the number of application days. The result is ascorbic acid 2-gluco

It has been shown that sid has an effect of improving wrinkles on the skin.

[0162]

<Experiment 10: Anti-wrinkle test of 2-glucoside ascorbic acid (2)>

Although not specified in Experiment 9, in Experiment 9, volunteers around the age of 40

, The average depth of wrinkles on the outer corners of both eyes tended to be shallower than that of volunteers of other ages.

Therefore, ascorbic acid was separately taken from 10 female volunteers aged 40 ± 2 years.

The action of the cream containing 2-glucoside was investigated in more detail. That is, the test period

The same ascorbic acid 2 used in Experiment 9 in the same manner as in Experiment 9 except that the interval was 42 days.

-Use a cream containing glucoside to improve fine wrinkles on the outer corners of both eyes in the same manner as in Experiment 9. 20

When the effect was tested (hereinafter referred to simply as "additional test"), 6 out of 10 subjects

In addition to the remarkable effect of improving fine wrinkles on the outer corners of the eyes, the gloss and moisturizing state of the skin on the outer corners of the eyes was observed.

Was also good. In addition, in this additional test, immediately before and after the start of the test, the skin on the outer corner of the eye

A method for measuring the turnover of the stratum corneum based on the cell area of the stratum corneum (slide) for the purpose of examining the overload.

Law) ("Fragrance Journal", Vol. 36, No. 5, pp. 28-30, 2008

According to (see), the adhesive tape is individually pressed against the outer corners of both eyes of 10 subjects to the skin surface.

After collecting the stratum corneum cells on the surface, staining, and measuring the area of the stratum corneum cells, each of the measurements was taken before this test.

The area of the stratum corneum cells at the outer corners of both eyes of the subject was compared. The stratum corneum turnover measurement method is based on the angle.

Estimate skin turnover rate by measuring layer cell area (cell size)

This is a relatively simple method. In this measurement method, the cell area of the stratum corneum and the turnover of the stratum corneum 30

As a relationship, the faster the turnover of the stratum corneum, the smaller the area of stratum corneum cells.

The turnover of the stratum corneum corresponds to the division rate of the basal cells that produce keratinocytes,

Furthermore, the turnover speed of the stratum corneum and the turnover speed of the skin are in direct proportion to each other.

Is based on.

[0163]

According to the results of the stratum corneum turnover measurement, the area of the stratum corneum cells at the outer corners of both eyes of the six subjects was

On average, it decreased by about 5% compared to just before the test, and the turnover rate of the stratum corneum at the outer corners of both eyes (basal cell)

The division rate) was increased by about 1.2 times on average. 42 days set in this additional test

The test period is equivalent to a little less than one cycle of skin turnover corresponding to the age of the volunteer.

Considering that, and that the delay in turnover is said to induce fine wrinkles. 40

Then, the result of this test shows that the cream immediately improves the delay in skin turnover, and the small size

It shows that it has an improving effect. In addition, the age of 40 ± 2 years is the turn of the skin.

The number of days required for a bar is about twice that of people in their twenties, and fine wrinkles are noticeable.

Therefore, the cream includes the so-called pre-aging generation, especially middle-aged women, including the age group.

It is extremely useful as a fine wrinkle improving agent for sex.

[0164]

<Experiment 11: Crystals of 2-glucoside-sodium salt ascorbic acid>

<Experiment 11-1: Preparation of ascorbic acid 2 glucoside-sodium salt crystals>

Ascorbic acid 2-glucoside anhydrous crystal-containing powder (trade name "AA2G", Hayashihara Co., Ltd.

(Manufactured) 100 g is dissolved in 100 ml of 6N sodium hydroxide, and then methanol is further dissolved. 50
 (66) JP 2018-90631 A 2018.6.14

When 100 ml of the mixture was added, stirred, and allowed to stand at 4 ° C. for about 3 weeks, cloudiness was observed, and a microscope view was observed.

As a result, the formation of crystals was observed. Filtering the crystalline suspension with a glass filter

Collect the crystals precipitated by the above method and use a 70% by volume methanol aqueous solution containing 0.1 N hydrochloric acid.

After washing, it was dried at 40 ° C. to obtain about 35 g of crystal powder.

[0165]

<Experiment 11-2: Examination of formation conditions for ascorbic acid 2-glucoside-sodium salt crystals>

Ascorbic acid 2-glucoside anhydrous crystal-containing powder (trade name "AA2G", Hayashihara Co., Ltd.

(Manufactured) 10 ml of 1 to 10 N sodium hydroxide aqueous solution shown in Table 12 below with respect to 10 g.

After adding and dissolving, add 10 ml of methanol, mix, and use as seed crystals in Experiment 11-1.

30 mg of the obtained ascorbic acid 2-glucoside-sodium salt crystal was added, and the temperature was 4 ° C. for 24 hours. Ten

It was allowed to stand and the degree of crystal precipitation was visually examined. The degree of crystal precipitation is

"-": Crystals do not precipitate

"+": Crystals are slightly precipitated

"++": Crystals precipitate about half of their capacity

"+++": Crystals precipitate and solidify throughout

Judgment was made in four stages. The results are shown in Table 12.

[0166]
 (67) JP 2018-90631 A 2018.6.14

[Table 12]

Ten

20

30

[0167]

As shown in Table 12, ascorbic acid 2-glucoside anhydrous crystal-containing powder was added to 5N, 6N,

A sample to which methanol was added after dissolving in an aqueous solution of sodium hydroxide having a concentration of 8N and 10N.

Crystal precipitation is observed from each of these, and the amount of crystal precipitation increases as the sodium hydroxide concentration increases.

Increased. On the other hand, when the sodium hydroxide concentration is 4N or less, crystal precipitation is completely observed. 40
There wasn't. When the sodium hydroxide concentration is 5N, 2-glucosi ascorbic acid in solution

The molar ratio of do to sodium is 1.7, ascorbic acid 2-glucoside-sodium.

For the formation of salt crystals, hydroxylation of 1.7 or more in molar ratio with respect to 2-glucoside ascorbic acid

It turned out to require sodium.

[0168]

<Experiment 11-3: Ascorbic acid 2-glucoside-sodium salt crystal>

When about 10 g of the crystal powder obtained in Experiment 11-1 was vacuum dried at 50 ° C. for 24 hours, Experiment 1

Approximately 8.4 g of crystal powder having a different appearance from the crystals obtained in 1-1 was obtained. The obtained crystal is a fruit

It was considered to be a new crystal different from the crystal obtained in Experiment 11-1.

[0169] 50
 (68) JP 2018-90631 A 2018.6.14

<Experiment 12: Various analyzes of ascorbic acid 2-glucoside-sodium salt crystals>

Observation of crystal form and HPLC analysis for each of the crystals obtained in Experiments 11-1 and 11-3.

, Sodium content measurement, infrared absorption spectrum (FT-IR) measurement, and powder X-ray

The diffraction pattern was measured.

[0170]

<Experiment 12-1: Crystal shape>

The crystals obtained in Experiments 11-1 and 11-3 were placed on a slide glass, respectively, and phase-contrast microscopy was performed.

The shape of the crystal was observed using a mirror, and a photograph was taken. Photographs of each crystal are shown in Fig. 1 and Fig.

Shown in 2. As can be seen in FIG. 1, the shape of the crystal obtained in Experiment 11-1 is a thin plate or column.

It was in shape. On the other hand, as can be seen in FIG. 2, the shape of the crystal obtained in Experiment 11-3 is deformed. Ten

Although there were many things, it was plate-shaped.

[0171]

<Experiment 12-2: HPLC analysis>

The crystals obtained in Experiments 11-1 and 11-3 were dissolved in an appropriate amount of pure water, respectively, and under the following conditions.

It was subjected to HPLC analysis. As a control, reagent-grade ascorbic acid 2-glucoside anhydrous crystals

Containing powder (trade name "ascorbic acid 2-glucoside 999", purity 99.9% or more, strain

Analysis was performed under the same conditions using the formula company Hayashibara).

<HPLC analysis conditions>

Column: Wakopak Wakobeads T-330 H ＋ Type

(Inner diameter 10 mm x Length 300 mm) (Sold by Wako Pure Chemical Industries, Ltd.) 20

Eluent: 0.0001N nitric acid aqueous solution

Flow velocity: 0.5 ml / min

Temperature: Room temperature

Detection: Differential refractometer

[0172]

The crystals obtained in Experiments 11-1 and 11-3 were dissolved in pure water and subjected to HPLC analysis.

Even in the deviation chromatogram, in the case of the control ascorbic acid 2-glucoside anhydrous crystal

Similarly, only the peak of ascorbic acid 2-glucoside was detected, both of which were ascorbi.

The purity of 2-glucoside acid was about 100%, which was obtained in Experiments 11-1 and 11-3.

It was confirmed that the crystals contained ascorbic acid 2-glucoside as a constituent. 30

Ta.

[0173]

<Experiment 12-3: Measurement of water content>

The water content of the crystal powders obtained in Experiments 11-1 and 11-3 was measured by the conventional vacuum drying method (50 ° C.,

When measured in 24 hours), it was 14.9% by mass and 0.2% by mass, respectively.

From this result, the crystals obtained in Experiment 11-1 are hydrous crystals containing ascorbic acid 2-glucoside.

The crystals obtained in Experiment 11-3 are anhydrous crystals containing 2-glucoside ascorbic acid.

Was thought to be.

[0174]

<Experiment 12-4: Measurement of sodium content> 40

Anhydrous crystals obtained in Experiment 11-3 were weighed in 25 mg in terms of anhydride and dissolved in 50 ml of pure water.

Further, it was diluted 5 times with pure water to prepare a measurement sample. Inductively coupled plasma to the amount of sodium in the sample

For emission spectroscopic analyzer (ICP-AES) CIROS-120 (manufactured by Rigaku Corporation)

The measurement was performed under the following conditions.

[0175]

<ICP-AES measurement conditions>

Plasma power: 1400W

Plasma gas: 13.0 L / min

Auxiliary gas and nebulizer gas: 1.0 L / min

Blank: 1000-fold diluted solution of 60% by volume nitric acid 50

 (69) JP 2018-90631 A 2018.6.14

Sodium calibration curve solution: ICP Multi-Element Standard IV (Merck)

Diluted to 0.1 to 10 ppm

[0176]

The sodium content in the solid content of the anhydrous crystals obtained in Experiment 11-3 was 8.7% by mass. This

The values of are 1 mol of ascorbic acid 2-glucoside and 1 mol of anhydrous crystals obtained in Experiment 11-3.

Sodium and 1/2 mol of sodium hydroxide are assumed to be contained, i.e. ascor

Natori assuming that the molar ratio of 2-glucoside to sodium is 1: 1.5

Ascorbic acid was obtained because it was a value close to the theoretical value of 8.8% by mass of um content.

2-Glucoside-sodium salt crystals are added to 2 mol of ascorbic acid 2-glucoside.

It was considered to contain 3 mol of thorium. Ten

[0177]

As mentioned above, in the hydrous crystals of ascorbic acid 2-glucoside-sodium salt

The water content is about 15% by mass, ascorbic acid 2-glucoside, sodium and hydroxide.

Ascorbic acid 2-glucoside and water, assuming it contains sodium in the above molar ratio

The molar ratio of the offspring is approximately 1: 4, and the hydrous crystals are paired with one molecule of ascorbic acid 2-glucoside.

It will contain 4 molecules of water of crystallization.

[0178]

From the results of Experiments 12-1 to 12-4, the crystals obtained in Experiment 11-1 are ascorbic acid 2-

It is a hydrous crystal of glucoside-sodium salt, and the crystal obtained in Experiment 11-3 is ascorbic acid.

It was confirmed that it was an anhydrous crystal of 2-glucoside-sodium salt. 20

[0179]

<Experiment 12-5: FT-IR spectrum>

Potassium bromide 20 for infrared absorption spectrum analysis in 2 mg of anhydrous crystal powder obtained in Experiment 11-3

0 mg was added, crushed and mixed in an agate mortar, and molded into tablets was used for analysis. apparatus

An infrared spectrophotometer FTIR-8300 (manufactured by Shimadzu Corporation) was used. With control

Then, a reagent-grade ascorbic acid 2-glucoside anhydrous crystal-containing powder (trade name "ascorbin")

Acid 2-glucoside 999 ”, purity 99.9% or more, manufactured by Hayashibara Co., Ltd.), measured in the same way.

I decided. The results are shown in FIG.

[0180]

As can be seen in FIG. 3A, anhydrous crystal powder of ascorbic acid 2-glucoside-sodium salt. 30

The final FT-IR spectrum shows 1580 cm. -1 Large absorption was observed in the vicinity. on the other hand

, As seen in FIG. 3B, in the control ascorbic acid 2-glucoside anhydrous crystal-containing powder

No absorption was observed at that position, separately 1700 cm -1 And 1770 cm -1 Large in the vicinity

Absorption was observed. 1580 cm of anhydrous crystals of sodium salt -1 Big sucking in the vicinity

The yield is estimated to be due to the expansion and contraction vibration of the carbonyl group due to the influence of sodium contained in the crystal.

Was done. The difference between the two FT-IR spectra is ascorbic acid 2-glucoside-natri.

Ascorbic acid 2-glucoside is present in salt form in anhydrous crystalline powder of um salt

In contrast, ascorbin in the control ascorbic acid 2-glucoside anhydrous crystal-containing powder

The acid 2-glucoside was thought to be due to its presence in the form of a free acid.

[0181] 40

<Experiment 12-6: Powder X-ray diffraction pattern>

Powder X-ray diffractometer (trade name "X'Pert Pro MPD", Spectris Co., Ltd.

), And the hydrous formation of the ascorbic acid 2-glucoside-sodium salt obtained in Experiment 11-1.

Crystals and anhydrous crystals obtained in Experiment 11-3 were used as samples, and about 50 mg of each was silicon.

Place it on a non-reflective plate, irradiate it with Cu-Kα rays under the following conditions while rotating it, and powder it by the reflection method.

An X-ray diffraction pattern was obtained. The obtained powder X-ray diffraction pattern is shown in FIGS. 4A and 4B. As a contrast, the country

2-G ascorbic acid disclosed in the pamphlet of WO2012 / 033218

Lucoside hydrous crystal-containing powder (purity 99.5%, manufactured by Hayashibara Co., Ltd.) and reagent-grade ascorbi

Acid 2-glucoside anhydrous crystal-containing powder (trade name "ascorbic acid 2-glucoside 999"

], Purity 99.9% or more, manufactured by Hayashibara Co., Ltd.) was also measured in the same manner, and the obtained powder X-ray was obtained. 50
 (70) JP 2018-90631 A 2018.6.14

Diffraction charts are shown in FIGS. 4C and 4D.

[0182]

<Cu-Kα ray irradiation conditions>

X-ray tube current: 40mA

X-ray tube voltage: 45 kV

Wavelength: 1.5405 Å

[0183]

Hydrous crystals of ascorbic acid 2-glucoside-sodium salt are as seen in FIG. 4A.

, Diffraction angle (2θ) 6.8 °, 8.2 °, 14.3 °, 17.8 ° and 18.4 °

Diffraction peaks, while anhydrous crystals of ascorbic acid 2-glucoside-sodium salt Ten

, As seen in FIG. 4B, diffraction angles (2θ) 8.0 °, 9.0 °, 16.4 °, 17.9.

Diffraction peaks characteristic of ° and 20.8 ° were shown. Ascorbic acid 2-glucoside-nato

The hydrous crystals and anhydrous crystals of the lithium salt show different powder X-ray diffraction patterns, and they also show different powder X-ray diffraction patterns.

All of these are conventionally known powders containing ascorbic acid 2-glucoside hydrous crystals and anhydrous knots.

It was completely different from the powder X-ray diffraction pattern of the crystal-containing powder.

[0184]

From this result, the hydrous crystals of the ascorbic acid 2-glucoside-sodium salt of the present invention and

Both anhydrous crystals were found to be novel crystals.

[0185]

By the way, anhydrous crystals of ascorbic acid 2-glucoside-sodium salt were placed at a temperature of 25 ° C, relative to each other. 20

If left overnight at a humidity of 75.2% or higher, it absorbs moisture and the water content becomes almost constant at about 15% by mass.

The same powder X-ray diffraction pattern as the hydrous crystal of ascorbic acid 2-glucoside-sodium salt is shown.

As a result, the hydrous crystals became anhydrous crystals by drying, and the anhydrous crystals became hydrous due to moisture absorption.

It was thought that mutual conversion would occur by making a phase transition to each crystal.

[0186]

<Experiment 12-7: Single crystal X-ray crystal structure analysis>

Reagent-grade ascorbic acid 2-glucoside anhydrous crystal-containing powder (trade name "ascorbic acid 2"

-Glucoside 999 ", purity 99.9% or more, manufactured by Hayashibara Co., Ltd.) 2 g of 3N hydroxide

After dissolving in 10 ml of thorium, 30 ml of methanol is added, mixed, and allowed to stand at 4 ° C. for 3 weeks.

By placing, a single crystal of hydrous crystals of ascorbic acid 2-glucoside-sodium salt can be formed. 30

It was precipitated. Select an appropriate size from the obtained single crystals and coat with paraton oil.

X-ray diffraction putter under the following conditions by vibration photography after setting in an X-ray diffractometer.

Was measured. Using R-AXIS RAPID-R (manufactured by Rigaku Corporation) as the measuring device,

Analysis software is available in Crystal Structure Ver. 3.8.2 (Riga Co., Ltd.)

Made by K) was used.

[0187].

<Measurement conditions>

X-ray source: Cu

Output: 50kV-100mA

Incident X-ray: Cu-Kα ray 40

Incident X-ray size: Approximately 0.5 mmφ

Crystal size: 0.3 x 0.2 x 0.2 mm

Detector: Imaging plate

Measurement temperature: Approximately -170 ° C (nitrogen gas spraying method)

[0188]

The X-ray diffraction pattern of the single crystal is shown in FIG. Diffraction spots in the X-ray diffraction pattern

Many pots) were confirmed, and it was confirmed that the crystal was a single crystal. This single crystal X-ray

Hydrous crystals of ascorbic acid 2-glucoside-sodium salt obtained by crystal structure analysis

The crystallographic parameters of are summarized in Table 13.

[0189] 50
 (71) JP 2018-90631 A 2018.6.14

[Table 13]

[0190] Ten

From the obtained X-ray diffraction intensity data, ascorbic acid 2-glucosi, as shown in Table 13.

Hydrous crystals of do-sodium salt belong to the orthorhombic system, and the space group is Pbca (# 61), lattice setting.

The numbers are a = 6.9733 Å, b = 14.4839 Å, c = 19.3221 Å, V = 195.

1.54 Å 3 Was decided.

[0191]

<Experiment 13: Ascorbic acid 2-glucoside-sodium salt crystals and ascorbic acid 2-g

PH of formulation with lucoside anhydrous crystals>

Anhydrous binding of ascorbic acid 2-glucoside-sodium salt obtained by the method of Experiment 11-3 above

Crystals and Ascorbic Acid 2-Glucoside Anhydrous Crystal-Containing Powder (trade name "Ascorbic Acid 2-Glu"

Coside 999 ”, purity 99.9% or more, manufactured by Hayashibara Co., Ltd.) in terms of anhydride, Table 1 below 20

Formulated at a mass ratio of 100: 0 to 0: 100 shown in 4, then 10 times the volume of the compounded substance.

The pH of the aqueous solution obtained by dissolving in pure water was measured. The results are shown in Table 14.

[0192]
 (72) JP 2018-90631 A 2018.6.14

[Table 14]

Ten

20

30

40

[0193]

As can be seen in Table 14, anhydrous crystals of ascorbic acid 2-glucoside-sodium salt

The pH of the aqueous solution dissolved alone is 13.1 and ascorbic acid 2-glucoside anhydrous crystals.

The pH of the aqueous solution in which the contained powder was dissolved alone was 1.7. On the other hand, ascorbic acid 2-

Anhydrous crystals of glucoside-sodium salt and powder containing 2-glucoside anhydrous crystals of ascorbic acid

The pH of the aqueous solution of the compound was in the range of 12.9 to 2.6 depending on the compounding ratio. A 50
 (73) JP 2018-90631 A 2018.6.14

Using scorbic acid 2-glucoside-sodium salt and ascorbic acid 2-glucoside,

Ascorbic acid 2-glucosi by blending them in an appropriate ratio in terms of anhydride.

The aqueous solution can have a desired pH in a wide range of acidic to alkaline, especially 5

A weak alkali that is preferable in cosmetics production when blended in the range of 5:45 to 40:60.

It was found to exhibit a acidic or weakly acidic pH.

[0194]

<Experiment 14: Effect of ascorbic acid 2-glucoside-sodium salt on gelling agent>

Adjusting the effect of ascorbic acid 2-glucoside-sodium salt in the production of gel cosmetics

Therefore, as gelling agents that are widely used in the cosmetics field, 9 types of carbomas shown in Table 15 are used.

-(Carbomer (manufactured by Nikko Chemicals) 5 types, Hibiswaco (manufactured by Wako Pure Chemical Industries) 3 types, Ten

Acpec (manufactured by Sumitomo Seika Chemical Co., Ltd.), preservative and ascorbic acid 2-glucoside,

A model experiment was conducted to prepare a gel containing ascorbic acid 2-glucoside. That's right

When ascorbic acid 2-glucoside is added, use citric acid buffer and sodium hydroxide.

Adjusted to pH 6.5 and medium with ascorbic acid 2-glucoside-sodium salt

A place where a gel with a pH of around 6.5 that does not contain citrate buffer is prepared without performing a sum operation.

The properties of the obtained gels were compared.

[0195]

Add 5 g of each gelling agent and 7.5 g of pentylene glycol as a preservative to 237.5 g of water.

It was dissolved to prepare a gel base (concentration: 2% by mass). Also, it was obtained by the method of Experiment 12-1.

Ascorbic acid 2-glucoside-sodium salt Hydrous crystals are dissolved in water, and Ascor in 250 g 20

An aqueous solution containing 20 g of rubic acid 2-glucoside (hereinafter, "ascorbic acid 2-glucoside")

-Sodium salt aqueous solution ". ) Was prepared. Ascol for each gel base 25g

Add 25 g of an aqueous solution of 2-glucoside-sodium salt of binoic acid, and add water to make the total amount 1

A gel having a pH of around 6.5 was prepared at 00 g. On the other hand, ascorbic acid 2-gluco

20g of sid anhydrous crystal-containing powder (trade name "AA2G", sold by Hayashibara Co., Ltd.) to 100g of water

Dissolve and further citric acid buffer (1% by mass citric acid, 15% by mass sodium citrate) 2

2-glucosi ascorbic acid with the addition of 0 g and 24.7 g of 10 mass% sodium hydroxide

Neutralized solution (total amount 164.7 g, hereinafter, "ascorbic acid 2-glucoside neutralized water-soluble"

"Liquid". ) Was prepared. 2-Glucocy ascorbic acid for 25 g of each gel base

Add 16.47 g of a neutralized aqueous solution, add 2 g of 10% by mass sodium hydroxide, and add water. 30

Was added to make the total amount 100 g, and a gel having a pH of around 6.5 was prepared. Each gel (Cal

Bomber concentration: 0.5% by mass, ascorbic acid 2-glucoside concentration: 2% by mass) pH and

The results of observing the properties of the gel are shown in Table 15.

[0196]
 (74) JP 2018-90631 A 2018.6.14

[Table 15]

Ten

20

30

40

[0197]

As can be seen in Table 15, ascorbic acid 2-glucoside was used, and the citric acid buffer solution was arranged.

The gel base prepared by neutralizing with sodium hydroxide was partially viscous.

However, none of them had high fluidity and could not retain the shape as a gel. one

The gel base prepared with ascorbic acid 2-glucoside-sodium salt is

A gel was obtained in which the slippage maintained the viscosity and the shape as a gel was maintained. These results

Ascorbic acid 2-glucoside using ascorbic acid 2-glucoside-sodium salt

It is relatively easy to manufacture gel cosmetics that were difficult to prepare with Coside.

It's telling. 50
 (75) JP 2018-90631 A 2018.6.14

[0198]

<Experiment 15: Anti-wrinkle effect of lotion>

Based on the formulation shown in Table 16 (numerical value is mass%), three types of lotion, that is, ascorbin

Acid 2-glucoside-free lotion 1 (control), ascorbic acid 2-glucoside anhydrous crystals included

Contains 2% by mass of powder (trade name "AA2G", sold by Hayashibara Co., Ltd.) and hydrous acid as a neutralizing agent.

Toner using sodium citrate as a pH adjuster with citric acid and sodium citrate 2.

And, ascorbic acid 2-glucoside-sodium salt anhydrous obtained by the method of Example 2 described later.

2% by mass of crystal powder was blended to prepare a lotion 3 prepared without performing a neutralization operation to prevent wrinkles.

Volunteer tests on action were conducted.

[0199] Ten

(Toner 1): (1), (4) to (7) in Table 16 are dissolved in purified water (14) to prepare an aqueous phase.

Then, add polyoxyethylene oleyl alcohol (8) and fragrance (10) to this in advance.

The pH is adjusted to 6.5 by mixing the solution dissolved in (9) and using an appropriate amount of sodium hydroxide.

Manufactured in order.

(Toner 2): After dissolving (1), (4) to (7) in Table 16 in a part of purified water (14),

Ascorbic acid 2-glucoside anhydrous crystals contained as ascorbic acid 2-glucoside (2)

Powder (trade name "AA2G", sold by Hayashibara Co., Ltd.) is used to dissolve it, and then the hydroxide is added.

Neutralized with thorium and citric acid (11) and sodium citrate as pH regulators

The pH is adjusted to 6.5 by adding (12), and the remaining purified water is added to prepare an aqueous phase.

It was produced in the same manner as in Toner 1 except that it was used. 20

(Toner 3): Examples described later as ascorbic acid 2-glucoside-sodium salt (3)

The ascorbic acid 2-glucoside-sodium salt anhydrous crystal powder prepared by the method 2 is blended.

It was produced in the same manner as the lotion 1 except that the pH was set to 6.5.

[0200]
[Table 16]

30

40

[0201]

The anti-wrinkle action of each of the above-mentioned lotion 1 (control), lotion 2 and lotion 3

, The anti-fine wrinkle effect was investigated. That is, 30 women aged 37 to 55 who suffer from wrinkles and fine wrinkles.

Sex subjects were randomly divided into 3 groups of 10 people, and each group had a lotion. 50
 (76) JP 2018-90631 A 2018.6.14

Any of 1 to 3 was used twice a day (morning and evening) for 4 consecutive weeks. During the test period

, Normal daily life for subjects, except avoiding the use of cosmetics that claim to improve wrinkles

I was instructed to spend time. After the test period, all subjects were asked to improve wrinkles and fine wrinkles, and to have skin swelling.

We conducted a questionnaire survey on the improvement and usability. Wrinkles in each group

, Fine wrinkles or skin swelling were "improved" and "feeling good"

The number of people is summarized in Table 17.

[0202]

[Table 17]

Ten

[0203]

As shown in Table 17, Toner 1 "had an improving effect" on wrinkles, fine wrinkles and skin swelling.

Less than 2 out of 10 subjects answered, but more than 6 respondents answered "Revised" for lotions 2 and 3.

It had a positive effect. " Also, regarding the feeling of use, the lotion 1 was "good". 20

The number of respondents was 3 out of 10, but 5 for lotion 2 and 7 for lotion 3 were "good".

I liked it. " During the test period, there was no skin trouble and the safety smell.

There was no problem. The above results show ascorbic acid 2-glucoside or its sodium salt.

Compared to the lotion without ascorbic acid 2-glucoside, the lotion using

It shows that it has an excellent effect of improving and giving skin elasticity.

[0204]

<Experiment 16: Anti-stain and buckwheat action of emulsion>

Three types of emulsions (emollient lotions) based on the formulations shown in Table 18 (values are mass%)

), That is, ascorbic acid 2-glucoside-free emulsion 1 (control), ascorbic acid

2-Glucoside anhydrous crystal-containing powder (trade name "AA2G", sold by Hayashibara Co., Ltd.) 3% by mass 30

Emulsion 2 blended, neutralized and pH adjusted with sodium hydroxide, and Examples described below.

3% by mass of ascorbic acid 2-glucoside-sodium salt anhydrous crystal powder obtained by method 2

After combining and obtaining the emulsion 3 prepared without performing the neutralization operation, it is related to anti-spot and freckle action.

A volunteer test was conducted.

[0205]

(Emulsion 1): Add (7) to (9) and (14) of Table 18 to purified water (15), heat and mix, and water.

Sodium oxide was used to prepare an aqueous phase with a pH of 7.0. Separately, (1) to (5) in Table 18 are mixed.

It was heated to 70 ° C. to prepare an oil phase. This oil phase part is added to the aqueous phase to perform pre-emulsification, and then

After uniformly emulsifying and cooling with a homomixer, triethanolamine (6) and carboxybi

A milky lotion was produced by adding the nylpolymer (10) and the fragrance (11). 40

(Emulsion 2): Ascorbic acid 2-glucosi as ascorbic acid 2-glucoside (12)

De Anhydrous crystal-containing powder (trade name "AA2G", sold by Hayashibara Co., Ltd.) is used, and this is purified water (1).

It was dissolved in a part of 4), and sodium hydroxide (14) was added to neutralize and adjust the pH to 7.0.

It was produced in the same manner as in Emulsion 1 except that the product was added last.

(Emulsion 3): Examples described later as ascorbic acid 2-glucoside-sodium salt (13)

Using ascorbic acid 2-glucoside-sodium salt anhydrous crystal powder prepared by the method of 2.

This was dissolved in a part of purified water (14) and added last, except that the pH was adjusted to 7.0.

Was produced in the same manner as the emulsion 1.

[0206]
 (77) JP 2018-90631 A 2018.6.14

[Table 18]

Ten

20

[0207]

Examine the anti-spot and freckle effects of the emulsion 1 (control), emulsion 2 or emulsion 3 obtained above.

Ta. That is, 30 female subjects aged 22 to 51 who suffer from spots and freckles are randomly selected.

Divide into 3 groups of 10 people each, and for each group, take any of emulsions 1 to 3 to 4

It was used continuously for a week. During the test period, the subjects will be advocated for the effect of improving spots and freckles.

Instructed them to spend their normal daily life except to avoid using cosmetics. End of test period

After that, the improvement effect of skin spots and freckles was judged by a questionnaire survey. Test results are shown in Table 19 30

It was shown to.

[0208]
[Table 19]

40

[0209]

As shown in Table 19, spots and freckles answered "improved" with emulsion 1 (control).

Was 1 out of 10 subjects, and 2 out of 10 subjects answered that they had "slightly improved".

In contrast, with emulsions 2 and 3, more than 7 people said that they had "improved" or "slightly improved".

I answered. During the test period, there were no skin problems and there were no safety issues.

.. The above results show that emulsions using ascorbic acid 2-glucoside or sodium salts thereof are

Compared to emulsion without ascorbic acid 2-glucoside, it is superior in the effect of improving stains and buckwheat.

It shows that it is a product.

[0210]

<Experiment 17: Anti-slacking effect of wash pigment> 50

 (78) JP 2018-90631 A 2018.6.14

Based on the formulation shown in Table 20 (numerical value is mass%), 3 types of washing pigments (face washing cream), sushi

That is, ascorbic acid 2-glucoside-free washing pigment 1 (control), ascorbic acid 2-g

Contains 2% by mass of lucoside anhydrous crystal-containing powder (trade name "AA2G", sold by Hayashihara Co., Ltd.)

, Facial cleanser 2 using potassium hydroxide for neutralization and pH adjustment, and the method of Example 3 described later.

2% by mass of the ascorbic acid 2-glucoside-sodium salt anhydrous crystal powder obtained in the above was blended, and p.

Volunteer on anti-slacking effect after obtaining face wash 3 prepared without using H adjuster

The test was conducted.

[0211]

(Facial cleanser 1): (11) to (13) in Table 20 were dissolved in purified water (14) to prepare an aqueous phase. Separately

, (1) to (8) in Table 20 are mixed and melted in advance, and the above aqueous phase is added to the oil phase adjusted to 70 ° C. Ten

The mixture was gradually added while stirring and kept at 70 ° C. to complete the saponification reaction. Do not stir this

Wash your face at pH 9.0 by cooling it to 50 ° C, mixing it uniformly, and cooling it to 25 ° C.

Manufactured a cleansing cream.

(Facial cleanser 2): Ascorbic acid 2-glucoside as ascorbic acid 2-glucoside (9)

De Anhydrous crystal-containing powder (trade name "AA2G", sold by Hayashibara Co., Ltd.) is used and refined in advance.

Dissolve in a part of water (14), neutralize with potassium hydroxide, and mix with the cooled washing pigment.

It was produced in the same manner as in face wash 1 except for the above.

(Facial cleanser 3): Ascorbic acid 2-glucoside-sodium salt (10), which will be described later.

Ascorbic acid 2-glucoside-sodium salt anhydrous crystal powder prepared by the method of Example 2 was used.

, Except that it was dissolved in a part of purified water (14) and blended in the face wash after cooling without neutralization. 20

It was produced in the same manner as Pigment 1.

[0212]
[Table 20]

30

40

[0213]

The anti-sagging effect of the face wash 1 (control), face wash 2 or face wash 3 obtained above was examined.

That is, a group of 30 male and female subjects aged 36 to 58 who suffer from loose skin.

Divide into 3 groups of 10 people so that the ratio of men and women is almost the same, and each group

Then, any of the facial cleansers 1 to 3 was used continuously for 4 weeks. During the test period, the subjects were asked

Spend normal daily life except avoiding the use of cosmetics that claim to improve skin slack.

I instructed. After the test period is over, the effect of improving skin slack is judged by a questionnaire survey.

did. The results are shown in Table 21. 50

 (79) JP 2018-90631 A 2018.6.14

[0214]
[Table 21]

[0215] Ten

As shown in Table 21, Facial Cleanser 1 (control) answered that the looseness of the skin was "improved".

Was 2 out of 10 subjects, and 2 out of 10 subjects answered that they had "slightly improved".

On the other hand, 8 respondents answered "improved" or "slightly improved" in facial cleansers 2 and 3.

.. During the test period, there were no skin problems and there were no safety problems. the above

The result is that facial cleansers using ascorbic acid 2-glucoside or its sodium salt are ascortic

Compared to facial cleansers without corbic acid 2-glucoside, it has an excellent effect of improving skin slack.

It shows that it is.

[0216]

<Experiment 18: Whitening and anti-wrinkle effect of beauty essence>

Based on the formula shown in Table 22 (numerical value is mass%), three types of beauty essences, that is, ascorbi 20

Beauty liquid 1 without addition of acid 2-glucoside (control), ascorbic acid 2-glucoside anhydrous crystals

Contains 3% by mass of powder (trade name "AA2G", sold by Hayashibara Co., Ltd.), and sodium hydroxide

The beauty essence 2 adjusted to pH 6.5 using a essence, and Asco obtained by the method of Example 3 described later.

A pH adjuster is used with 3% by mass of rubic acid 2-glucoside-sodium salt anhydrous crystal powder.

Prepare the beauty essence 3 prepared without shavings and conduct a volunteer test on whitening and anti-wrinkle effects.

Ta.

[0217]

(Essence 1): (1) to (5) and (12) to (18) are mixed according to the compounding method shown in Table 22.

To this, a mixture of (9) to (11) was added in advance to homogenize, and (8) was added to pH.

Was adjusted to 6.5 to produce a beauty essence. 30

(Essence 2): Ascorbic acid 2-glucoside as ascorbic acid 2-glucoside (6)

De Anhydrous crystal-containing powder (trade name "AA2G", sold by Hayashibara Co., Ltd.) is blended in 3% by mass, and water acid

It was produced in the same manner as the beauty essence 1 except that it was used after adjusting the pH to 6.5 with potassium.

(Essence 3): Examples described later as ascorbic acid 2-glucoside-sodium salt (7)

The ascorbic acid 2-glucoside-sodium salt anhydrous crystal powder prepared by the method 2 is blended.

, Same as beauty essence 1 except that the pH was adjusted to 6.5 without neutralization with potassium hydroxide.

Manufactured in this way.

[0218]
 (80) JP 2018-90631 A 2018.6.14

[Table 22]

Ten

20

[0219]

The beauty essence 1 (control), beauty essence 2 or beauty essence 3 obtained above has a whitening effect and anti-wrinkle effect.

I checked the usage. That is, 30 female subjects aged 26 to 48 who suffer from dull skin and wrinkles. 30
Randomly divided into 3 groups of 10 people each, and for each group, 1 to 3 serums

Either was used continuously for 4 weeks. During the test period, the subjects were given a whitening effect and wrinkle improvement.

Instructed to spend normal daily life except avoiding the use of cosmetics that advocate good effects

.. After the end of the test period, the skin whitening effect and wrinkle improvement effect were judged by a questionnaire survey.

The test results are shown in Table 23.

[0220]

[Table 23]

40

[0221]

As shown in Table 23, Essence 1 (control) was effective for whitening and wrinkles were "improved".

1 out of 10 subjects answered, and 10 subjects answered "slightly improved".

In contrast to 1 of the names, 7 of them "improved" or "slightly improved" with serums 2 and 3.

I answered. During the test period, there were no skin problems, and there were also safety issues.

There wasn't. The above results used ascorbic acid 2-glucoside or a sodium salt thereof. 50
 (81) JP 2018-90631 A 2018.6.14

The beauty essence has a whitening effect and wrinkles compared to the beauty essence without ascorbic acid 2-glucoside.

It shows that it is excellent in the effect of improving.

[0222]

Hereinafter, the present invention will be described in more detail based on Examples. However, the present invention

It is not limited by the examples.

[Example 1]

[0223]

<Cosmetic material>

Ascorbic acid 2-glucoside anhydrous crystal-containing powder (trade name "AA2G", Hayashihara Co., Ltd.

(Sold) 500 g was dissolved in 500 ml of an 8N sodium hydroxide aqueous solution. Etano to this Ten

750 ml of all was added, the mixture was stirred, and the mixture was allowed to stand at 4 ° C. for 5 days to precipitate crystals. Glass fill

Precipitated crystals are recovered by filtering with a tar and washed with a small amount of 70% ethanol aqueous solution.

After that, it is dried at 40 ° C. and crushed to ascorbic acid 2-glucoside-natri.

326 g of a water-containing crystal-containing powder of um salt was obtained.

[0224]

This product is a novel crystal-containing powder of ascorbic acid 2-glucoside, and is a conventional ascor.

Similar to powder containing 2-glucoside anhydrous crystals, as a cosmetic material and quasi-drugs

It can also be used advantageously as a material for pharmaceuticals and foods. The aqueous solution of this product is alkaline

Therefore, the conventional method of neutralizing ascorbic acid 2-glucoside with alkali is inconvenient.

It can be used advantageously in the manufacture of the resulting product. 20

[Example 2]

[0225]

<Cosmetic material>

Hydrous crystal-containing powder of ascorbic acid 2-glucoside-sodium salt obtained by the method of Example 1.

Ascol is obtained by pulverizing 100 parts by mass of the powder after drying under reduced pressure at 50 ° C. for 24 hours.

81 parts by mass of anhydrous crystal-containing powder of biacid 2-glucoside-sodium salt was obtained.

[0226]

This product is a novel crystal-containing powder of ascorbic acid 2-glucoside, and is a conventional ascor.

Similar to powder containing 2-glucoside anhydrous crystals, as a cosmetic material and quasi-drugs

It can also be used advantageously as a material for pharmaceuticals and foods. The aqueous solution of this product is alkaline 30

Therefore, the conventional method of neutralizing ascorbic acid 2-glucoside with alkali is inconvenient.

It can be used advantageously in the manufacture of the resulting product.

[Example 3]

[0227]

<Cosmetic material>

Anhydrous crystal-containing powder of 2-glucoside-sodium salt of ascorbic acid obtained by the method of Example 2.

Ascorbic acid 2-glucoside anhydrous crystal-containing powder (trade name "AA2") based on 55 parts by mass of powder

G ”, sold by Hayashibara Co., Ltd.) 45 parts by mass were uniformly mixed to obtain a powdery cosmetic material.

[0228]

This product is a novel powder containing anhydrous crystals of 2-glucoside-sodium salt of ascorbic acid. 40

It is a compound of powder containing ascorbic acid 2-glucoside anhydrous crystals, which has been widely used since now.

As a cosmetic material, as well as the conventional powder containing ascorbic acid 2-glucoside anhydrous crystals.

It can also be used advantageously as a material for quasi-drugs, pharmaceuticals, foods, etc. In addition, the water content of this product

Since the liquid is weakly alkaline, it is a conventional powder containing 2-glucoside anhydrous crystals of ascorbic acid.

It can be easily adjusted to a desired pH as compared with the case where powder is used.

[Example 4]

[0229]

<Cosmetic material>

Hydrous crystal-containing powder of ascorbic acid 2-glucoside-sodium salt obtained by the method of Example 1.

Ascorbic acid 2-glucoside anhydrous crystal-containing powder with respect to 50 parts by mass of powder in terms of anhydride 50
 (82) JP 2018-90631 A 2018.6.14

(Product name "AA2G", sold by Hayashihara Co., Ltd.) 50 parts by mass are mixed evenly to make a powdered cosmetic product.

I got the material.

[0230]

This product is a novel powder containing hydrous crystals of 2-glucoside-sodium salt of ascorbic acid.

It is a compound of powder containing ascorbic acid 2-glucoside anhydrous crystals, which has been widely used since now.

As a cosmetic material, as well as the conventional powder containing ascorbic acid 2-glucoside anhydrous crystals.

It can also be used advantageously as a material for quasi-drugs, pharmaceuticals, foods, etc. In addition, the water content of this product

Since the liquid is weakly acidic, the conventional powder containing 2-glucoside anhydrous crystals of ascorbic acid is used.

It can be easily adjusted to a desired pH as compared with the case of using it.

[Example 5] Ten

[0231]

<Toner>

(Combined prescription)

Ingredients (mass%)

(1) Glycerin 4.0

(2) Propylene glycol 3.0

(3) 1,2-Pentanediol 0.1

(4) Cosmetic material obtained by the method of Example 3 2.0

(5) Polyoxyethylene (20 mol) olein alcohol 0.5

(6) Yukinoshita extract 2.0 20

(7) Ethanol 5.0

(8) Fragrance Appropriate amount

(9) Purified water Remaining amount

[0232]

After dissolving the components (1) to (4) of the above formulation in purified water (9), the components (5) to (8)

Toner was prepared by gradually adding and mixing the mixture. This product is stable

It is an excellent lotion that exerts anti-wrinkle effect, not only anti-wrinkle effect and anti-fine wrinkle effect, but also beauty.

Whitening action, as well as anti-spotting, anti-slacking action, barrier function in the skin and hyaluronic acid production

It is useful as an anti-aging lotion that is also excellent in maintaining or enhancing the effect. Also, 1,

Since it contains 2-pentanediol, it has excellent antiseptic effect and moisturizing properties, and is less irritating to the skin. 30

In addition, precipitation of active ingredients such as ascorbic acid 2-glucoside is also suppressed, resulting in stability.

It is an excellent lotion.

[Example 6]

[0233]

<Toner>

(Combined prescription)

Ingredients (mass%)

(1) Glyceryl monostearate 0.5

(2) Olive oil 0.5

(3) Glycerin 6.0 40

(4) 1,3-butylene glycol 10.0

(5) Ethanol 5.0

(6) Cosmetic material obtained by the method of Example 1 1.0

(7) Arbutin 1.0

(8) Fragrance Appropriate amount

(9) Purified water Remaining amount

[0234]

(Production method)

Ingredients (1) and (2) of the above formulation are heated to 70 ° C. and mixed uniformly, and the ingredients (

3), (4), purified water (9), a part of water was mixed and heated, and the mixture was added and mixed (Phase A). A 50
 (83) JP 2018-90631 A 2018.6.14

Rubutin (7) was dissolved in the remaining purified water (9) (Phase B). Gradually add phase A to phase B

After mixing, the components (5) and (8) are mixed, and (6) is added to form a microemulsion.

I got a lotion.

[0235]

Since this product forms a microemulsion, it is transparent, highly stable, and has a stable anti-shiki.

An excellent lotion that exerts a wrinkle effect, not only anti-wrinkle effect and anti-fine wrinkle effect, but also whitening effect

, And also anti-stain, anti-slacking, barrier function in skin and maintenance of hyaluronic acid production

Alternatively, it is useful as an anti-aging lotion having an excellent enhancing effect. Also, 1,3-bu

Since it contains ethylene glycol, it has excellent antiseptic effect and moisturizing properties, and is less irritating to the skin.

But it is an excellent lotion. Ten

[Example 7]

[0236]

<Emulsion>

(Combined prescription)

Ingredients (mass%)

(1) 1,2-Hexanediol 5.0

(2) Octyldodecanol 4.0

(3) Kojic acid 1.0

(4) Cosmetic material obtained by the method of Example 3 1.0

(5) Polyoxyethylene oleyl ether (20EO) 1.0 20

(6) Stearic acid 0.5

(7) Shea butter 2.0

(8) Beeswax 4.0

(9) Paraoxybenzoic acid ester 0.2

(10) Quince seed extract 5.0

(11) Xanthan gum 0.1

(12) Phytic acid 0.02

(13) Vitamin E 0.01

(14) Purified water Remaining amount

[0237] 30

The above components (1), (3), (10), (11) and purified water (14) are mixed to form an aqueous phase.

Ta. Next, the components (2), (5) to (9), (12) and (13) are heated and mixed to form an oil phase.

did. The aqueous phase is added to the oil phase and mixed uniformly, then cooled, and the component (4) is added and mixed uniformly.

And obtained a milky lotion. This product is an excellent emulsion that exerts a stable anti-wrinkle effect, and has an anti-wrinkle effect.

Not only anti-fine wrinkle effect, but also whitening effect, anti-spot, anti-slack effect, barrier in skin

-An anti-aging emulsion with excellent function and hyaluronic acid production maintenance or enhancement effect

Is useful.

[Example 8]

[0238]

<Gel-like emulsion> 40

(Combined prescription)

Ingredients (mass%)

(1) Squalane 5.0

(2) Trioctanoin 6.0

(3) Olive oil 5.0

(4) Macademian nut oil 5.0

(5) Isopropyl palmitate 5.0

(6) Polyglyceryl monomyristate-10 5.5

(7) POE isostearate (60) glyceryl-10 3.0

(8) Propylene glycol stearate SE 2.0 50

 (84) JP 2018-90631 A 2018.6.14

(9) Carboxyvinyl polymer 0.5

(10) Potassium hydroxide Appropriate amount

(11) Syrup containing a sugar derivative of trehalose 15.5

(Product name "Tornale", Hayashibara Sales Co., Ltd.)

(12) Cosmetic material obtained by the method of Example 2 1.0

(13) Kanzo extract 0.1

(14) Hyaluronic acid 0.25

(15) 5'-Glucosyl adenosine 0.2

(16) 1,2-Pentanediol 3.5

(17) Fragrance Appropriate amount Ten

(18) Purified water Remaining amount

[0239]

After dissolving the components (11) to (16) in a part of the purified water (18), the components (1) to (10)

And (17) were added and emulsified by a conventional method to prepare a gel emulsion. This product is a stable anti

A makeup that has a wrinkle effect, an excellent whitening effect, is not sticky, and has a good usability.

Elle. In addition, this product does not use a citrate buffer and has a relatively low salt concentration.

It is an excellent cosmetic gel that has high stability and has stable anti-wrinkle and anti-fine wrinkle effects.

Yes, whitening effect, anti-spot effect, anti-slack effect, barrier function in skin and hearing

It is available as a gel-like emulsion for anti-aging, which has an excellent effect of maintaining or enhancing lulon acid production.

For. 20

[Example 9]

[0240]

<Cosmetic emulsion>

(Combined prescription)

Ingredients (mass%)

(1) Stearic acid 2.5

(2) Cetanol 1.5

(3) Vaseline 5.0

(4) Liquid paraffin 10.0

(5) Polyoxyethylene oleate 2.0 30

(6) Tocopherol acetate 0.5

(7) Dipotassium glycyrrhizinate 0.2

(8) Polyethylene glycol (1500) 3.0

(9) Cosmetic material obtained by the method of Example 4 3.0

(10) Eye water extract 3.0

(11) 1,2-Hexanediol 0.1

(12) Purified water Remaining amount

[0241]

According to the above formula, the ingredients are mixed by a conventional method, and then an appropriate amount of fragrance is added to make a milky lotion.

Manufactured. This product exerts stable anti-wrinkle action, anti-fine wrinkle action, and whitening action. 40

Also excellent in barrier function in skin and maintenance or enhancement of hyaluronic acid production

As an anti-aging emulsion with excellent usability that does not feel sticky even when applied to the skin

For.

[Example 10]

[0242]

<Cosmetic cream>

(Combined prescription)

Ingredients (mass%)

(1) Stearic acid 5.0

(2) Cetyl alcohol 5.0 50

 (85) JP 2018-90631 A 2018.6.14

(3) Squalene 8.0

(4) Vaseline 3.0

(5) Glycerol tri2-ethylhexanoic acid ester 7.0

(6) Dipropylene glycol 6.0

(7) Glycerin 4.0

(8) Cosmetic material obtained by the method of Example 1 2.0

(9) Propylene glycol monostearic acid ester 3.0

(10) Polyoxyethylene (20) cetyl alcohol ether 3.0

(11) 1,2-Hexanediol 0.2

(12) Fragrance Appropriate amount Ten

(13) Purified water Remaining amount

[0243]

Ingredients (6) and (7) were added to purified water (13) and heated to 60 ° C. to prepare an aqueous phase. Separately

, Ingredients (1) to (5), (9) to (12) are mixed and heated to 70 ° C. to prepare an oil phase.

, Was added to the previously prepared aqueous phase. After adding the component (8) to this, it is emulsified by a conventional method and creeped.

Manufactured. This product has a stable anti-wrinkle effect and also has an excellent whitening effect on the skin.

Excellent in maintaining or enhancing the barrier function and hyaluronic acid production in

It is useful as an anti-aging cosmetic cream that does not have a good feeling of use.

[Example 11]

[0244] 20

<Cosmetic cream>

(Combined prescription)

Ingredients (mass%)

(1) Decaglyceryl monostearate 1.2

(2) Decaglyceryl monomyristate 1.8

(3) Stearyl alcohol 0.5

(4) Behenyl alcohol 3.0

(5) Bacil alcohol 1.0

(6) Cetyl palmitate 1.0

(7) Glyceryl stearate 1.8 30

(8) Fatty acid (C10-30) (cholesteryl / lanosteryl) 2.0

(9) Isopropyl palmitate 4.0

(10) Squalene 5.0

(11) Octyldodecyl myristate 5.0

(12) Macademian nut oil 0.5

(13) Trioctanoin 1.8

(14) Dimethicone 0.3

(15) Butylene glycol 6.0

(16) Pentylene glycol 2.5

(17) Concentrated glycerin 12.0 40

(18) Polyquaternium-51 0.25

(19) Cosmetic material obtained by the method of Example 1 2.0

(20) Anhydrous crystal maltitol 3.0

(21) Fragrance Appropriate amount

(22) Purified water Remaining amount

[0245]

The components (1) to (14) and (21) of the above formulation were heated and mixed to prepare an oil phase. Then the ingredients

(15)-(18), (20) and (22) were mixed to prepare an aqueous phase. Mix the water phase with the oil phase

After cooling, the component (19) was added and mixed to prepare a cream. This product has a stable anti-wrinkle effect

It also has an excellent whitening effect, and has a barrier function on the skin and hyaluronic acid production. 50
 (86) JP 2018-90631 A 2018.6.14

For anti-aging, which has excellent raw maintenance or enhancement effect, is not sticky and has a good usability

It is useful as a cosmetic cream.

[Example 12]

[0246]

<Essence>

(Combined prescription)

Ingredients (mass%)

(1) Maltitol 7.5

(2) Cosmetic material obtained by the method of Example 3 3.0

(3) 1,2-Alkanediol 5.0 Ten

(4) Polyethylene glycol 1500 1.0

(5) Ethanol 5.0

(6) Carboxyvinyl polymer 0.4

(7) Sodium polyacrylate 0.1

(8) Polyoxyethylene oleyl ether (20EO) 1.5

(9) Olive oil 0.2

(10) Dipotassium glycyrrhizinate 0.1

(11) Potassium hydroxide Appropriate amount

(12) Fragrance Appropriate amount

(13) Purified water Remaining amount 20

[0247]

According to the above formulation, the ingredients were mixed by a conventional method to prepare a beauty essence. This product is stable

It has anti-wrinkle and anti-fine wrinkle effects, and also has excellent whitening effect, which is a barrier on the skin.

-Excellent function and hyaluronic acid production maintenance or enhancement effect, sticky even when applied to the skin

It is useful as an anti-aging beauty essence that has no feeling and is excellent in usability.

[Example 13]

[0248]

<Pack>

(Combined prescription)

Ingredients (mass%) 30

(1) Polyvinyl alcohol 5.0

(2) Pullulan 12.0

(3) Carboxymethyl cellulose 6.0

(4) 1,3-butylene glycol 6.0

(5) Ethanol 8.0

(6) 1,2-Pentanediol 0.1

(7) Cosmetic material obtained by the method of Example 4 3.0

(8) Polyoxyethylene oleyl ether 0.5

(9) Fragrance Appropriate amount

(10) Purified water Remaining amount 40

[0249]

According to the above formulation, the ingredients were mixed by a conventional method to prepare a pack. This product is stable

It exerts anti-wrinkle and anti-fine wrinkle effects, and also has a barrier function on the skin and hyaluro.

As an anti-aging pack with excellent acid production maintenance or enhancement action and whitening action

It is useful, and it is easy to wash it off after applying it to the skin.

[Example 14]

[0250]

<Facial cleansing foam>

(Combined prescription)

Ingredients (Mass part) 50

 (87) JP 2018-90631 A 2018.6.14

(1) Potassium laurate 2.0

(2) Potassium myristate 17.0

(3) Palmitic acid 4.0

(4) Stearic acid 4.0

(5) Palm kernel oil fatty acid diethanolamide 3.0

(6) Glycerin 10.0

(7) 1,3-butylene glycol 10.0

(8) Syrup containing a sugar derivative of trehalose 5.0

(Product name "Tornale", Hayashibara Sales Co., Ltd.)

(9) Cosmetic material obtained by the method of Example 2 3.0 Ten

(10) Ethylenediaminetetraacetic acid 4 sodium 0.2

(11) Sodium cocoyl methyl taurine 10.0

(12) Purified water Remaining amount

[0251]

A facial cleansing foam was prepared by a conventional method according to the above formulation. This product has stable anti-wrinkle action and anti-wrinkle effect.

Exhibits fine wrinkle action and maintains barrier function and hyaluronic acid production in the skin

Or because it has excellent enhancing, whitening, and anti-staining effects, and a moist finish can be obtained.

, Useful as an anti-aging facial cleansing foam.

[Example 15]

[0252] 20

<Liquid soap>

(Combined prescription)

Ingredients (Mass part)

(1) Lauric acid 4.0

(2) Propylene glycol stearate 0.2

(3) Octildo Decess-10 1.5

(4) Otildo Decess-20 1.5

(5) Ceteares-60 millistilgle call 2.0

(6) N-coconut oil fatty acid acylglycine potassium solution 10.0

(7) Sodium cocoamphoacetate 40.0 30

(8) Syrup containing a sugar derivative of trehalose 4.0

(Product name "Tornale", Hayashibara Sales Co., Ltd.)

(9) Cosmetic material obtained by the method of Example 1 2.0

(10) Glycerin 2.0

(11) Ethylenediaminetetraacetic acid disodium 0.2

(12) Methylparaben 0.1

(13) Purified water Remaining amount

[0253]

A liquid soap was prepared by a conventional method according to the above formulation. This product has a stable anti-wrinkle effect,

Exhibits anti-fine wrinkle effect, barrier function in skin and hyaluronic acid production 40

It has excellent long-lasting or enhancing action, whitening action, and anti-staining action, and a moist finish can be obtained.

Therefore, it is useful as a liquid soap for anti-aging.

[Example 16]

[0254]

<Body soap>

(Combined prescription)

Ingredients (Mass part)

(1) Lauric acid 5.0

(2) Oleic acid 5.0

(3) Sodium cocoyl methyl taurine 18.0 50

 (88) JP 2018-90631 A 2018.6.14

(4) Sodium cocoamphoacetate 20.0

(5) Hyaluronic acid 2.0

(6) Syrup containing a sugar derivative of trehalose 1.0

(Product name "Tornale", Hayashibara Sales Co., Ltd.)

(7) Cosmetic material obtained by the method of Example 2 2.0

(8) Sodium chloride 0.2

(9) Etidronic acid 0.1

(10) Ethylenediaminetetraacetic acid disodium 0.1

(11) Potassium hydroxide Appropriate amount

(12) Purified water Remaining amount Ten

[0255]

A body soap was prepared by a conventional method according to the above formulation. This product has stable anti-wrinkle

It exerts action and anti-fine wrinkle action, and also has a barrier function in the skin and hyaluronic acid production.

It has excellent raw maintenance or enhancement action, whitening action, and anti-staining action, and gives a moist finish.

It is useful as a body soap for anti-aging.

[Example 17]

[0256]

<Cleansing>

(Combined prescription)

Ingredients (Mass part) 20

(1) Liquid paraffin 35.0

(2) Vaseline 17.0

(3) Cetyl alcohol 3.0

(4) Stearic acid 2.0

(5) Glycerin 3.0

(6) Propylene glycol 2.0

(7) Polyoxyethylene isocetyl ether (10EO) 2.5

(8) Stearic acid glyceride 2.5

(9) 1,2-Pentanediol 0.2

(10) Cosmetic material obtained by the method of Example 3 1.0 30

(11) Fragrance Appropriate amount

(12) Purified water Remaining amount

[0257]

A cleansing cream was prepared by a conventional method according to the above formulation. This product is for the skin

A refreshing cleansing cream used for cleaning and removing makeup.

.. In addition, it exerts stable anti-wrinkle and anti-fine wrinkle effects and is a barrier on the skin.

Excellent effect on maintenance or enhancement of function and hyaluronic acid production, whitening effect, and anti-spot effect

It is useful as a cleansing cream for anti-aging.

[Example 18]

[0258] 40

<Sunscreen for whitening (oil-in-water emulsification type)>

(Combined prescription)

Ingredients (mass%)

(1) Decaglyceryl pentaoleate 1.5

(2) Polyoxyethylene (10 mol) cholesteryl ether 1.0

(3) Hydrogenated soybean phospholipids 1.5

(4) Glycerin 5.0

(5) 2-ethylhexyl paramethoxycinnamate 5.0

(6) Dipropylene glycol 10.0

(7) Arbutin 3.0 50

 (89) JP 2018-90631 A 2018.6.14

(8) Diethylenetriamine pentasodium acetate pentasodium salt 0.1

(9) Cosmetic material obtained by the method of Example 3 1.0

(10) Malic acid 0.2

(11) Ethanol 2.0

(12) Fragrance Appropriate amount

(13) Methyl paraoxybenzoate Appropriate amount

(14) Sodium hydroxide Appropriate amount

(15) Purified water Remaining amount

[0259]

(Production method) Ten

A. The components (1) to (3) and (5) are heated to 75 ° C. and uniformly mixed and dissolved.

B. Ingredients (4), (6) to (10), (14) and (15) are heated to 75 ° C. and mixed uniformly.

Combine and dissolve.

C. B is added to A and emulsified.

D. C was cooled and components (11) to (13) were added to obtain a sunscreen (whitening type).

[0260]

This product has a stable whitening effect, anti-wrinkle effect, anti-fine wrinkle effect, and on the skin.

It also has an excellent barrier function and hyaluronic acid production maintenance or enhancement effect, and spreads and spreads on the skin.

Is uniform, non-sticky, has excellent moisturizing effects such as smoothing the texture of the skin, and is cheap over time.

It is useful as an anti-aging sunscreen (oil-in-water emulsification type) with excellent qualitative properties. 20

[Example 19]

[0261]

<Whitening emulsion (oil-in-water emulsification type)>

(Combined prescription)

Ingredients (mass%)

(1) Decaglyceryl pentastearate 0.5

(2) Polyoxyethylene (10 mol) cholesteryl ether 0.2

(3) Jojoba oil 3.0

(4) Hydrogenated soybean phospholipid (trade name "Resinol S-10", 2.5

Nikko Chemicals Co., Ltd.) 30

(5) Glycerin 5.0

(6) Dipropylene glycol 10.0

(7) Arbutin 7.0

(8) Cosmetic material obtained by the method of Example 3 1.0

(9) Ethylenediamine tetraacetic acid disodium salt 0.1

(10) Succinic acid 0.1

(11) Ethanol 5.0

(12) Sodium hydroxide Appropriate amount

(13) Purified water Remaining amount

[0262] 40

(Production method)

A. The components (1) to (4) are heated to 75 ° C. and uniformly mixed and dissolved.

B. Ingredients (5) to (10), (12) and (13) are heated to 75 ° C. and uniformly mixed and dissolved.

To.

C. B is added to A and emulsified.

D. C was cooled and the component (11) was added to obtain a whitening emulsion (oil-in-water emulsification type).

[0263]

This product exerts stable anti-wrinkle and anti-fine wrinkle effects and is a barrier on the skin.

-It has excellent functions and hyaluronic acid production maintenance or enhancement, whitening and anti-spot effects, and is suitable for the skin.

It spreads evenly, is not sticky, and has excellent moisturizing effects such as smoothing the texture of the skin. 50
 (90) JP 2018-90631 A 2018.6.14

Is available as an anti-aging whitening emulsion (oil-in-water emulsification type) with excellent stability over time.

For.

[Example 20]

[0264]

<Skin turnover improvement cosmetic base material>

(Combined prescription)

Ingredients (mass%)

(1) Ascorbic acid 2-glucoside anhydrous crystal-containing powder 25.0

(Product name "AA2G", Hayashibara Sales Co., Ltd.)

(2) α-Glucosylrutin 0.1 Ten

(Product name "αG Rutin", manufactured by Toyo Sugar Refining Co., Ltd.)

(3) Polyoxyethylene alkyl ether 0.9

(4) Olive leaf extract having a turnover improving effect 0.01

(5) Potassium hydroxide Appropriate amount

(6) Sodium citrate Appropriate amount

(7) Purified water Remaining amount

[0265]

Ingredients (1) to (7) of the above formulation are stirred at room temperature, mixed, dissolved, and then membrane filtered.

By doing so, a cosmetic base material (pH 6.0) for improving skin turnover is prepared, and the light-shielding property is increased.

The vessel was filled. This product has the effect of improving skin turnover by blending it with various cosmetics. 20

Stable anti-wrinkle effect, anti-fine wrinkle effect, barrier function on the skin

And maintenance or enhancement of hyaluronic acid production, whitening effect, anti-staining effect, anti-slacking effect

Can be granted. In particular, this product has an olive leaf extraction effect that has a turnover improving effect.

Since the product and α-glucosylrutin are mixed, combined with the action of component (1),

Along with the immediate effect of improving skin turnover, it also protects the skin from UV rays and prevents oxidation.

It is also extremely useful in that it can effectively impart action. In addition, this product is so-called pre-aging

Suitable for various cosmetics as a quick-acting fine wrinkle improver for middle-aged women as well as generations

Can be blended. In addition, various cosmetics containing an appropriate amount of this product are busy with daily work.

For busy women who tend to neglect skin care, apply the appropriate amount to the skin before going to bed at night.

When applied, the active ingredient effectively penetrates the skin during bedtime and immediately improves skin turnover. 30

Can be good.

[Example 21]

[0266]

<Skin turnover improvement cosmetic base material>

(Combined prescription)

Ingredients (mass%)

(1) Ascorbic acid 2-glucoside anhydrous crystal-containing powder 25.0

(Product name "AA2G", Hayashibara Sales Co., Ltd.)

(2) Ganoderma lucidum extract or Stinkhorn extract 0.01

(3) Has a turnover improving effect and a saccharification reaction suppressing effect 0.02 40

Eucommia leaf extract

(4) Glycerin fatty acid ester 0.8

(5) Sodium hyaluronate 1.0

(6) Potassium hydroxide Appropriate amount

(7) Purified water Remaining amount

[0267]

Ingredients (1) to (7) of the above formulation are stirred at room temperature, mixed and dissolved, and then pH 6.

Two types of skin turnover improving cosmetic base materials are prepared by adjusting to 0 and filtering the membrane.

did. By blending this product with various cosmetics, it gives the effect of improving skin turnover.

Along with stable anti-wrinkle action, anti-fine wrinkle action, barrier function on the skin and hearing 50
 (91) JP 2018-90631 A 2018.6.14

By imparting maintenance or enhancement of rulon acid production, whitening effect, anti-staining effect, and anti-slacking effect

Wear. In particular, this product has a turnover improving effect and a saccharification reaction suppressing effect.

Ingredients (1) because the product and Ganoderma lucidum extract or Stinkhorn extract are mixed.

), Combined with the immediate effect of improving skin turnover, it can also provide skin

The anti-aging effect is also effectively exhibited. In addition, sugar used in combination with ascorbic acid 2-glucoside

Eucommia leaf extract, which has an inhibitory effect on the chemical reaction, effectively suppresses the production of advanced glycation end products (AGEs).

Since it can be controlled, it is possible to reduce or suppress the deposition of unwanted AGEs on the skin tissue.

At the same time, in the process of producing AGEs, disordered cross-linking within and between molecules of collagen occurs.

Reduces or reduces the formation of collagen that causes physical and physiological changes (denaturation)

Effective for skin aging such as wrinkles, rough skin, dullness, or reduction of elasticity because it can be suppressed. Ten

Can be prevented or improved. In addition, this product includes the so-called pre-aging generation.

As a quick-acting fine wrinkle improver for middle-aged women, it can be suitably blended in various cosmetics.

Wear. In addition, various cosmetics containing an appropriate amount of this product are busy with daily work and care for the skin.

In a busy woman who tends to be lonely, if you apply the appropriate amount to the skin before going to bed at night, you will go to bed

The active ingredient effectively penetrates into the skin, and skin turnover can be improved immediately.

To.

[Example 22]

[0268]

<Skin turnover improvement cosmetic base material>

(Combined prescription) 20

Ingredients (mass%)

(1) Ascorbic acid 2-glucoside anhydrous crystal-containing powder 25.0

(Product name "AA2G", Hayashibara Sales Co., Ltd.)

(2) Polyoxyethylene alkyl ether 0.9

(3) Olive leaf extract having a turnover improving effect,

Licorice extract, wheat germ extract, sage extract,

Mint extract, camellia leaf extract, eye extract,

Aloe extract, olive leaf extract, chamomile extract,

Yukinoshita extract, Yuzu extract, Lemon extract,

Rosemary extract, chlorella extract, royal jelly 30

Any one selected from the extract or gardenia jasmine extract

0.01 mass%

(4) Potassium hydroxide Appropriate amount

(5) Sodium citrate Appropriate amount

(6) Purified water Remaining amount

[0269]

Any one of the extracts shown in the components (1), (2) and (3) of the above formulation, and (4) No.

To (6) is stirred at room temperature, mixed, dissolved, and then membrane-filtered to turn the skin.

-Prepare a bar-improving cosmetic base material (pH 6.0), fill it in a light-shielding container, and 17 types of skin tasting.

A cosmetic base material with improved cloudover was obtained. By blending this product with various cosmetics, it can be used on the skin. 40

It can impart a cloudover improving effect, and also has a stable anti-wrinkle effect, anti-fine wrinkle effect, and skin.

Barrier function and maintenance or enhancement of hyaluronic acid production, whitening effect, and even anti

It can impart stain action and anti-slack action. In particular, this product improves skin turnover.

Since it contains a plant extract that has an action, it has an immediate effect in combination with the action of the component (1).

Along with improving the turnover of sexual skin, it also protects the skin from ultraviolet rays and has an antioxidant effect.

It is also extremely useful in that it can be effectively given. In addition, this product is the so-called pre-aging generation.

Not to mention, it is suitable for various cosmetics as a quick-acting fine wrinkle improver for middle-aged women.

can do. In addition, various cosmetics containing an appropriate amount of this product are busy with daily work, and the skin's skin

For busy women who tend to be neglected, apply the appropriate amount to the skin before going to bed at night

Then, the active ingredient effectively penetrates the skin during bedtime and immediately improves skin turnover. 50
 (92) JP 2018-90631 A 2018.6.14

Can be

[Example 23]

[0270]

<Preservative sterilization cosmetic base material>

(Combined prescription)

Ingredients

(mass%)

(1) Ascorbic acid 2-glucoside anhydrous crystal-containing powder 25.0

(Product name "AA2G", Hayashibara Sales Co., Ltd.)

(2) Photosensitizer 201 (Hayashibara Co., Ltd.) 0.01 Ten

(3) 1,2-Pentanediol, 1,2-hexanediol

1,2-Heptanediol or 1,2-octanediol

2.0% by mass of any one selected from

(4) Hyaluronic acid 1.0

(5) Peony extract having a saccharification reaction inhibitory effect 1.0

(6) Glycerin fatty acid ester 0.8

(7) Pullulan (Product name "Pullulan for cosmetics", Hayashibara Co., Ltd.) 0.4

(8) Potassium hydroxide Appropriate amount

(9) Purified water Remaining amount

[0271] 20

Any one of the components (1) and (4) to (9) and (2) and (3) of the above-mentioned compounding formulation.

And each were stirred at room temperature, mixed and dissolved, and then both were mixed to adjust the pH to 6.0.

Four kinds of antiseptic and sterilizing cosmetic base materials were prepared by membrane filtration and filled in a light-shielding container.

In particular, since this product contains a peony extract that has an inhibitory effect on saccharification reaction.

, Combined with the action of component (1), it can impart a remarkable skin turnover improving effect.

In addition, the skin aging suppressing effect is also effectively exhibited. In addition, this product is blended in the desired amount in various cosmetics.

By doing so, stable anti-wrinkle action, anti-fine wrinkle action, barrier function in the skin and hearing

By imparting maintenance or enhancement of rulon acid production, whitening effect, anti-staining effect, and anti-slacking effect

A liquid cosmetic base material that can be used, especially for middle-aged women, including the so-called pre-aging generation.

As a quick-acting fine wrinkle improving agent, it can be suitably blended in various cosmetics. Furthermore, in this product 30

, 1,2-pentanediol, 1,2-hexanediol, 1, which has antiseptic and bactericidal action

With any one selected from 2-heptanediol or 1,2-octanediol

, Photoreceptor 201, which has excellent compatibility with them, is blended in high concentration, so various cosmetics

An excellent antiseptic effect can be exhibited by blending an appropriate amount into. In addition, pullulan is distributed to this product.

Since it is combined, it can effectively impart a moisturizing effect to the skin in combination with the ingredient (1).

It is also useful as a cosmetic base material. In addition, various cosmetics containing an appropriate amount of this product can be used in daily work.

For busy women who tend to be chased and neglected to care for their skin, the appropriate amount before going to bed at night

When applied to the skin, the active ingredient effectively penetrates the skin during bedtime, immediately turning over the skin.

It can be effectively improved.

[Example 24] 40

[0272]

<Skin turnover improvement cosmetic base material>

(Combined prescription)

Ingredients (mass%)

(1) Ascorbic acid 2-glucoside anhydrous crystal-containing powder 25.0

(Product name "AA2G", Hayashibara Sales Co., Ltd.)

(2) Hyaluronic acid 1.0

(3) Wild strawberry with turnover improving effect 0.01

Extract

(4) Has a turnover improving effect and a saccharification reaction suppressing effect 0.01 50
 (93) JP 2018-90631 A 2018.6.14

Equol

(5) Polyoxyethylene cured castor oil 1.0

(6) Potassium hydroxide Appropriate amount

(7) Sodium citrate Appropriate amount

(8) Purified water Remaining amount

[0273]

The components (1) to (8) of the above formulation are stirred while being heated, mixed, dissolved, and then a membrane filter.

By passing, a cosmetic base material (pH 6.0) that improves skin turnover is prepared and has a light-shielding property.

The container was filled. In particular, this product is a wild strawberry that has a turnover improving effect.

The extract and equol, which has a turnover improving effect and a saccharification reaction suppressing effect, are arranged. Ten

Since it is combined, it has an immediate effect on skin turnover in combination with the action of ingredient (1).

It can be effectively improved, and has stable anti-wrinkle effect, anti-fine wrinkle effect, and barrier on the skin.

Maintenance or enhancement of function and hyaluronic acid production, whitening effect, anti-staining effect, anti-slacking effect

Can exert its action. In addition, this product is for middle-aged women, including the so-called pre-aging generation.

As a quick-acting fine wrinkle improving agent, it can be suitably blended in various cosmetics. Further

In addition, various cosmetics containing an appropriate amount of this product are busy with daily work and neglect to care for the skin.

For busy women who tend to be busy, applying an appropriate amount to the skin before going to bed at night is effective during bedtime.

The ingredients can effectively penetrate the skin and improve skin turnover immediately.

[Example 25]

[0274] 20

<Skin turnover improvement cosmetic base material>

(Combined prescription)

Ingredients (mass%)

(1) Ascorbic acid 2-glucoside anhydrous crystal-containing powder 25.0

(Product name "AA2G", Hayashibara Sales Co., Ltd.)

(2) Hyaluronic acid 1.0

(3) Turnover improving effect and / or saccharification reaction suppressing effect

Ashwagandha extract, Thujopsis dorsalis extract,

Anyakunoki extract, Ginkgo extract,

Winter green extract, sardine extract, orange 30

Extract, pumpkin seed extract, cuttlefish bark extract,

Mallotus philippans extract, cowberry extract, perilla extract,

Peony extract, buckwheat leaf extract, dabira rugosa extract,

Houttuynia cordata extract, Elatostema umbellata extract, Benibanaboro

Giku extract, Actinidia polygama extract, Ryukyuchiku extract,

Ryukyu rose strawberry extract, apple immature fruit extract,

Persimmon leaf extract, licorice leaf extract, moon peach leaf extract, pearl protein

Hydrolyzate, equol, isoflavones, ifenprodil,

Selected from catechol, caffeic acid, or prunin

1.0 mass% of any one 40

(4) Glycerin fatty acid ester 0.8

(5) Potassium hydroxide Appropriate amount

(6) Purified water Remaining amount

[0275]

Any one of the components (1), (2), and (3) shown in the above-mentioned formulation, (4) to (6)

After stirring and mixing at room temperature, the pH is adjusted to 6.0 and membrane filtration is performed to obtain 32 types of skin.

A cosmetic base material for improving turnover was prepared and filled in a light-shielding container. Especially, this product has a tar

Contains plant extracts or other ingredients that have an over-improving effect and / or a saccharification reaction suppressing effect.

Therefore, in combination with the action of ingredient (1), it has a remarkable effect of improving skin turnover.

Can be given, and the effect of suppressing skin aging is also effectively exhibited. In addition, this product is various 50
 (94) JP 2018-90631 A 2018.6.14

By blending in the desired amount in cosmetics, it has stable anti-wrinkle effect, anti-fine wrinkle effect, and skin rash.

Maintenance or enhancement of rear function and hyaluronic acid production, whitening effect, and anti-spot effect,

A liquid cosmetic base material capable of imparting an anti-slacking effect, particularly including the so-called pre-aging generation.

As a quick-acting fine wrinkle improver for middle-aged women, it can be suitably blended in various cosmetics.

To. In addition, various cosmetics containing an appropriate amount of this product are busy with daily work, and skin care is neglected.

In a busy woman who tends to get sick, if you apply the appropriate amount to the skin before going to bed at night, it will be sleeping

The active ingredient effectively penetrates the skin and can immediately improve skin turnover.

..

[Example 26]

[0276] Ten

<Skin turnover improver>

Four kinds of skin turnover improving agents of the present invention were prepared according to the following formulation.

That is, as the following component (17), Example 20 and Example 21 (two types of skin turno)

-Among the base materials for improving cosmetics, which contains Ganoderma lucidum), the skin obtained in Example 24

Turnover improvement cosmetic base material or powder containing ascorbic acid 2-glucoside anhydrous crystals

Using.

[0277]

<Test cream>

(Combined prescription)

Ingredients (mass%) 20

(1) Dimethicon 0.3

(2) Squalan 2.0

(3) Cetearyl isononanoate 1.0

(4) Triethylhexanoin 2.0

(5) Octildodecanol 2.0

(6) Fatty acid (C-10-30) (cholesteryl / lanosteryl) 3.0

(7) Polyglyceryl myristate-10 3.5

(8) Cetanol 3.5

(9) Bacil alcohol 1.0

(10) Cetyl palmitate 2.0 30

(11) Glyceryl stearate SE 2.5

(12) Batyl stearate 2.5

(13) 1,3-butylene glycol 3.0

(14) Methylparaben 0.2

(15) Glycerin 4.5

(16) Silap containing a sugar derivative of trehalose 2.0

(Product name "Tornale", Hayashibara Sales Co., Ltd.)

(17) Improvement of skin turnover obtained in Examples 20, 21 or 24

20.0% by mass of cosmetic base material, or 2-g ascorbic acid

Lucoside anhydrous crystal-containing powder (trade name "AA2G", Stock Association 40

Company Hayashibara sales) 5.0% by mass

(18) Malic acid 0.02

(19) Sodium malate 0.3

(20) Potassium hydroxide 0.3

(21) Lanolin 0.1

(22) Purified water Appropriate amount

[0278]

All of the above four types of skin turnover improving agents exert an excellent fine wrinkle improving effect.

For middle-aged women, including the so-called pre-aging generation, who have an excellent effect of improving fine wrinkles with aging.

It is extremely useful as a fast-acting anti-wrinkle improver. The skin obtained in Example 21 or 24. 50
 (95) JP 2018-90631 A 2018.6.14

Turnover improvement agent for skin prepared using cosmetic base material is Asco

Along with rubic acid 2-glucoside, it has a turnover improving effect and a glycation reaction suppressing effect.

Since it contains other ingredients, it is combined with ascorbic acid 2-glucoside.

-Skin turnover improving makeup of Example 20 in which only ingredients having a bar improving effect are blended.

Better skin turnover compared to skin turnover improvers prepared with a base material

-The speed improvement effect is exhibited. In addition, the skin turnover improving cosmetic base material of Example 20 was used.

The skin turnover improving agent prepared in use contains ascorbic acid as the component (17).

Compared to skin turnover improvers prepared with 2-glucoside anhydrous crystal-containing powder.

It has an excellent skin turnover speed improvement effect and is a barrier machine for the skin.

Maintenance or enhancement of Noh and hyaluronic acid production, whitening effect, anti-spot effect, anti-slackening effect Ten

It is also useful.

[Industrial applicability]

[0279]

The anti-aging skin external composition of the present invention, or a lotion or face wash containing the same.

Basic cosmetics such as beauty essence, milky lotion, or cream have excellent anti-wrinkle, anti-fine wrinkle, and anti-spot.

And anti-slack effect, barrier function in skin and maintenance or enhancement effect of hyaluronic acid production

Because it plays, it is a way to realize the universal desire of all humankind to be youthful forever.

It is extremely effective as a step.

[0280]

In addition, the anti-aging external composition for skin of the present invention, or a lotion or wash containing the same. 20

Basic cosmetics such as pigments, beauty essences, milky lotions, or creams are water-based based on the active ingredient.

It can be easily manufactured by a manufacturing method including a step of mixing with a medium, which is particularly preferable.

Also in crystalline form as the component ascorbic acid 2-glucoside or its sodium salt

When using, it is possible to use a high-purity raw material with few impurities.

Not to mention the point, it is extremely excellent that you can always expect constant known and stable physical properties.

Benefits are obtained.

[0281]

Further, in the production method of the present invention, ascorbic acid 2-glucoside-sodium salt formation

When crystals and ascorbic acid 2-glucoside anhydrous crystals are used in combination, the mixing ratio of both to be used

Neutralize ascorbic acid 2-glucoside with alkali by adjusting 30

Since the pH of the product can be adjusted within a predetermined range without having to do so, the anti-Ai of the present invention

Topical skin composition for ging, or a lotion, facial cleanser, beauty essence, milky lotion, youthful

Has the advantage that basic cosmetics such as cream can be manufactured more easily with fewer steps.

Is obtained. The present invention has various advantages as described above, and its industrial usefulness.

Is huge.

[Explanation of symbols]

[0282]

In FIG.

A: FT-IR spectrum of anhydrous crystals of ascorbic acid 2-glucoside-sodium salt

B: FT-IR spectrum of powder containing ascorbic acid 2-glucoside anhydrous crystals (control) 40

In FIG. 4,

A: Powder X-ray diffraction pattern of hydrous crystals of ascorbic acid 2-glucoside-sodium salt

B: Powder X-ray diffraction pattern of anhydrous crystals of ascorbic acid 2-glucoside-sodium salt

C: Powder X-ray diffraction pattern of ascorbic acid 2-glucoside hydrous crystal-containing powder (control 1)

D: Powder X-ray diffraction pattern of ascorbic acid 2-glucoside anhydrous crystal-containing powder (control 2)
 (96) JP 2018-90631 A 2018.6.14

FIG. 1 FIG. 3

FIG. 2

FIG. 4 FIG. 5
 (97) JP 2018-90631 A 2018.6.14

[Procedure amendment]

[Submission date] April 17, 2018 (April 17, 2018)

[Procedure amendment 1]

[Name of document subject to amendment] Claims

[Item name to be corrected] Full text

[Correction method] Change

[Details of correction]

[Claims]

[Claim 1]

Induction of L-ascorbic acid and L-ascorbic acid as active ingredients based on an aqueous medium

Anti-aging skin containing one or more selected from conductors and salts thereof

Topical composition.

2.

The derivative of L-ascorbic acid is a glycosyl derivative of L-ascorbic acid, which induces acylation.

The composition for external use on the skin for anti-aging according to claim 1, which is a conductor or a phosphorylated derivative.

3.

The glycosyl derivative of L-ascorbic acid is 2-O-α-D-glucosyl-L-ascor

It is a biacid, the salt of which is a sodium salt, 2-O-α-D-glucosyl-L-as.

The anti-aging skin according to claim 2, which contains corbic acid and / or a sodium salt thereof.

Topical composition.

4.

The invention according to any one of claims 1 to 3, which prevents or improves wrinkles, fine wrinkles, age spots, or slack.

Topical skin composition for anti-aging.

5.

Claims 1 to 4 that maintain or enhance the barrier function and hyaluronic acid production in the skin.

The anti-aging skin external composition according to any one of.

6.

A plant extract or compound that has a skin turnover improving effect and / or a glycation reaction suppressing effect.

The anti-e according to any one of claims 1 to 5, further comprising one type or two or more types selected from the products.

Topical skin composition for Ising.

7.

A plant extract or compound that has a skin turnover improving effect and / or a glycation reaction suppressing effect.

The thing is the extract of Cupressaceae plant, the extract of Ginkgoaceae plant, the extract of Rutaceae plant,

Lamiaceae plant extract, Lizard tails plant extract, Eucommiaceae plant extract, and d

Qol claims 6 The above-mentioned external composition for anti-aging skin.

8.

Cupressaceae is Asunaro, Ginkgoaceae is Ginkgo, and Rutaceae is Oubaku.

, Orange, grapefruit, citron, and lemon, Labiatae plants are mint, peppermin

To, perilla, and rosemary, plants of the family Houttuynia cordata, and plants of the family Eucommia ulmoides

The composition for external skin for anti-aging according to claim 7, which is Chu.

9.

2-O-α-D-glucosyl-L-ascorbic acid per composition is L-ascorbic

1 to 10% by mass in terms of acid anhydride, skin turnover improving effect and / or saccharification reaction Suppression

System A total of one or more selected from active plant extracts, compounds, and equol

A claim comprising 0.01 to 1% by mass. 7 or Topical anti-aging skin according to 8.

Composition.

10.

Basic makeup containing the anti-aging skin external composition according to any one of claims 1 to 9.

Goods.

11.
 (98) JP 2018-90631 A 2018.6.14

The basic cosmetic according to claim 10, which is a lotion, a cleanser, a beauty essence, a milky lotion, or a cream.

12.

One selected from L-ascorbic acid, derivatives of L-ascorbic acid, and salts thereof

Alternatively, any of claims 1 to 11, which comprises a step of mixing two or more kinds with an aqueous medium as a base.

The method for producing an anti-aging external composition for skin or basic cosmetics according to the above.

13.

The derivative of L-ascorbic acid is 2-O-α-D-glucosyl-L-ascorbic acid.

The salt is a sodium salt, 2-O-α-D-glucosyl-L-ascorbic acid.

1 and / or a step of mixing the sodium salt thereof with an aqueous medium as a base.

2. The method for producing an anti-aging external composition for skin or basic cosmetics according to 2.

14.

2-O-α-D-glucosyl-L-ascorbic acid and / or its sodium salt crystallizes

The production of the anti-aging skin external composition or basic cosmetics according to claim 13 in the form of

Method.

15.

The sodium salt of 2-O-α-D-glucosyl-L-ascorbic acid in crystalline form

, In powder X-ray diffraction, diffraction angles (2θ) 6.8 °, 8.2 °, 14.3 °, 17.8 °

2-O-α-D-glucosyl-L-ascorbic acid showing a diffraction peak at 18.4 °

Hydrous crystals of sodium salt or diffraction angles (2θ) 8.0 °, 9.0 °, 16.4

2-O-α-D-glucosyl-L- showing diffraction peaks at °, 17.9 °, and 20.8 °

The anti-aging skin according to claim 14, which is an anhydrous crystal of sodium ascorbate.

A method for producing an external composition or basic cosmetics.

16.

2-O-α-D-glucosyl-L-ascorbic acid and its sodium salt as a base

2-O-α-D-glucosyl-L-ascorbic acid in the step of mixing with the aqueous medium of

Including the step of mixing the sodium salt of the above with an aqueous medium as a base, using alkali 2-

Claims made without neutralizing O-α-D-glucosyl-L-ascorbic acid 13 No

The method for producing an anti-aging external composition for skin or basic cosmetics according to any one of 15 to 15.

..

17.

2-O-α-D-glucosyl-L-ascorbic acid and its sodium salt as a base

2-O-α-D-glucosyl-L used in the above step of mixing with the aqueous medium of

-The pH of ascorbic acid and its sodium salt after mixing with an aqueous medium was predetermined.

The anti-dose according to claim 16, which is in the form of a composition blended in a ratio within a predetermined range.

A method for producing an external composition for Ising or basic cosmetics.

18.

Contains 2-O-α-D-glucosyl-L-ascorbic acid and crystals of its sodium salt Mi

, 2-O-α-D-Glucosyl-L-ascorbic acid and its sodium salt crystal compounding ratio

Is in the range of 60:40 to 45:55 in terms of anhydrous mass ratio. Composition.

19.

Sodium salt crystals of 2-O-α-D-glucosyl-L-ascorbic acid are powdered X-rays

At times, the diffraction angles (2θ) are 6.8 °, 8.2 °, 14.3 °, 17.8 °, and 18.

2-O-α-D-glucosyl-L-sodium ascorbate salt showing a diffraction peak at 4 °

Hydrous crystal of, or diffraction angle (2θ) 8.0 °, 9.0 °, 16.4 °, 17.9

2-O-α-D-glucosyl-L-ascorbin showing diffraction peaks at ° and 20.8 °

Claim that it is an anhydrous crystal of sodium acid salt 18 The composition described.
 (99) JP 2018-90631 A 2018.6.14

Continuation of front page

(51) Int.Cl. FI Theme code (reference)

A61Q 19/00 (2006.01) A61Q 19/00

A61Q 19/08 (2006.01) A61Q 19/08

A61P 17/00 (2006.01) A61P 17/00

A61K 36/185 (2006.01) A61K 36/185

A61K 36/16 (2006.01) A61K 36/16

A61K 36/14 (2006.01) A61K 36/14

A61K 36/75 (2006.01) A61K 36/75

A61K 36/53 (2006.01) A61K 36/53

A61K 36/704 (2006.01) A61K 36/704

C07H 17/04 (2006.01) C07H 17/04

(72) Inventor Masaki Miyake

675-1, Fujisaki, Naka-ku, Okayama-shi, Okayama Hayashibara Co., Ltd.

(72) Inventor Waki human water

675-1, Fujisaki, Naka-ku, Okayama-shi, Okayama Hayashibara Co., Ltd.

F-term (reference) 4C057 BB02 DD01 KK02

4C083 AA072 AA082 AA111 AA112 AA122 AB032 AB332 AB352 AC012 AC022 AC122

AC072 AC092 AC102 AC112 AC302 AC132 AC172 AC182 AC242 AC252 AC402 AC422

AC342 AC352 AC392 AC542 AC642 AC432 AC442 AC482 AC532 AC782 AC792 AC842

AC662 AC712 AD092 AD112 AD132 AC892 AC902 AD042 AD212 AD262 AD272 AD332

AD152 AD492 AD512 AD532 AD572 AD352 AD392 AD641 AD642 AD662 CC03 CC04

CC23 DD23 DD27 DD31 CC05 DD33 EE12 FF04

4C086 AA01 AA02 EA11 GA15 4C088 MA01 MA04 MA63 NA14 AB43 ZA89 ZB22

AB02 AB03 AB12 AB38 AB61 AB62 CA03 MA63 NA14

ZA89 ZB22