What Is Depression
What Is Depression
Depression is a mood disorder that causes a persistent feeling of sadness and loss of interest. Also
called major depressive disorder or clinical depression, it affects how you feel, think and behave and
can lead to a variety of emotional and physical problems. You may have trouble doing normal day-to-
day activities, and sometimes you may feel as if life isn't worth living.
SYMPTOMS
CAUSES
It's not known exactly what causes depression. As with many mental disorders, a variety of factors
may be involved, such as:
Biological differences. People with depression appear to have physical changes in their
brains. The significance of these changes is still uncertain, but may eventually help pinpoint
causes.
Brain chemistry. Neurotransmitters are naturally occurring brain chemicals that likely play a
role in depression. Recent research indicates that changes in the function and effect of these
neurotransmitters and how they interact with neurocircuits involved in maintaining mood stability
may play a significant role in depression and its treatment.
Hormones. Changes in the body's balance of hormones may be involved in causing or
triggering depression. Hormone changes can result with pregnancy and during the weeks or
months after delivery (postpartum) and from thyroid problems, menopause or a number of other
conditions.
Inherited traits. Depression is more common in people whose blood relatives also have this
condition. Researchers are trying to find genes that may be involved in causing depression.
RISK FACTORS
Depression often begins in the teens, 20s or 30s, but it can happen at any age. More women than
men are diagnosed with depression, but this may be due in part because women are more likely to
seek treatment.
Factors that seem to increase the risk of developing or triggering depression include:
Certain personality traits, such as low self-esteem and being too dependent, self-critical or
pessimistic
Traumatic or stressful events, such as physical or sexual abuse, the death or loss of a loved
one, a difficult relationship, or financial problems
Blood relatives with a history of depression, bipolar disorder, alcoholism or suicide
Being lesbian, gay, bisexual or transgender, or having variations in the development of genital
organs that aren't clearly male or female (intersex) in an unsupportive situation
History of other mental health disorders, such as anxiety disorder, eating disorders or post-
traumatic stress disorder
Abuse of alcohol or recreational drugs
Serious or chronic illness, including cancer, stroke, chronic pain or heart disease
Certain medications, such as some high blood pressure medications or sleeping pills (talk to
your doctor before stopping any medication)
COMPLICATIONS
Depression is a serious disorder that can take a terrible toll on you and your family. Depression often
gets worse if it isn't treated, resulting in emotional, behavioral and health problems that affect every
area of your life.
Examples of complications associated with depression include:
Excess weight or obesity, which can lead to heart disease and diabetes
Pain or physical illness
Alcohol or drug misuse
Anxiety, panic disorder or social phobia
Family conflicts, relationship difficulties, and work or school problems
Social isolation
Suicidal feelings, suicide attempts or suicide
Self-mutilation, such as cutting
Premature death from medical conditions
PREVENTION
There's no sure way to prevent depression. However, these strategies may help.
Take steps to control stress, to increase your resilience and boost your self-esteem.
Reach out to family and friends, especially in times of crisis, to help you weather rough
spells.
Get treatment at the earliest sign of a problem to help prevent depression from worsening.
Consider getting long-term maintenance treatment to help prevent a relapse of
symptoms.