Dukewriting Lesson2-Answer
Dukewriting Lesson2-Answer
Principles:
1. Put new information last
2. Use passive voice judiciously
3. Make sure the first and last sentences of a paragraph match
Exercises (revise these sentences for clarity using the principles of this lesson):
1. These data were then subjected to hierarchical clustering using the Pearson
correlation as the distance metric.
Answer: we subjected the data to hierarchical clustering using the Pearson correlation
as the distance metric.
2. We designated the putative GRB target genes as the human TFs that were under a
HCNE density peak and whose orthologs were in conserved synteny with an array of
HCNEs in human:zebrafish alignments. Density peaks and syntenic regions were
downloaded from the Ancora Genome Browser.
Answer: Browser to designate the putative GRB target genes as the human TFs that
were under a HCNE density peak and whose orthologs were in conserved synteny
with an array of HCNEs in human:zebrafish alignments.
3. By analyzing all of the available mouse cDNA sequences, it was found that the
mouse genome encodes at least 44 000 distinct transcriptional units; a transcriptional
unit comprises all the RNAs that share a common exonic sequence transcribed from
the same genomic strand.
Answer: Transcriptional units comprise all the RNAs that share a common exonic
sequence transcribed from the same genomic strand; by analyzing all of the available
mouse cDNA sequences it was found that their genome encodes at least 44,000
different transcriptional units.
4. Improvements are expected in the predictive power of all the scores being computed
on multispecies alignments.
5. With the development of molecular embryology and the coming of the post-genomic
era, the molecular mechanisms of morphological evolution have recently begun to be
elucidated.