SAFETY DATA SHEET

Creation Date 02-Sep-2010 Revision Date 19-Apr-2012 Revision Number 5

SECTION 1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE
COMPANY/UNDERTAKING

Product Identifier
Product Description: 4-Aminophenol
Cat No. 104270000; 104270010; 104270050; 104272500
Synonyms 4-Amino-1-hydroxybenzene; 4-Hydroxyaniline

Relevant identified uses of the substance or mixture and uses advised against
Recommended Use Laboratory chemicals
Uses advised against No Information available

Details of the supplier of the safety data sheet

Company
Acros Organics BVBA
Janssen Pharmaceuticalaan 3a
2440 Geel, Belgium
E-mail address [email protected]

Emergency Telephone Number

For information in the US, call: 001-800-ACROS-01
For information in Europe, call: +32 14 57 52 11

Emergency Number, Europe: +32 14 57 52 99

Emergency Number, US: 001-201-796-7100

CHEMTREC Phone Number, US: 001-800-424-9300

CHEMTREC Phone Number, Europe: 001-703-527-3887

SECTION 2. HAZARDS IDENTIFICATION

Classification of the substance or mixture

REGULATION (EC) No 1272/2008
Acute oral toxicity Category 4
Acute Inhalation Toxicity - Dusts and Mists Category 4
Germ Cell Mutagenicity Category 2
Acute aquatic toxicity Category 1
Chronic aquatic toxicity Category 1

Classification according to EU Directives 67/548/EEC or 1999/45/EC

For the full text of the R-phrases and H-Statements mentioned in this Section, see Section 16
Symbol(s) Xn - Harmful
R-phrase(s) R68 - Possible risk of irreversible effects
Risk Combination Phrases R20/22 - Harmful by inhalation and if swallowed
R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic
environment

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SECTION 2. HAZARDS IDENTIFICATION

Label Elements

Signal Word Warning

Hazard Statements
H341 - Suspected of causing genetic defects
H410 - Very toxic to aquatic life with long lasting effects
H332 - Harmful if inhaled
H302 - Harmful if swallowed

Precautionary Statements - EU (§28, 1272/2008)

P281 - Use personal protective equipment as required
P304 + P340 - IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing
P301 + P312 - IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell
P273 - Avoid release to the environment

Other Hazards
No information available.

SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS

Component EC-No. Weight % CAS-No 67/548/EEC CLP REACH No.

Classification Classification -
Regulation (EC)
No 1272/2008
p-Aminophenol EEC No. 204-616-2 >95 123-30-8 Xn; R20/22 Acute Tox. 4 -
123-30-8 N; R50-53 (H302)
Muta.Cat.3; R68 Muta. 2 (H341)
Aquatic Acute 1
(H400)
Aquatic Chronic 1
(H410)

For the full text of the R-phrases and H-Statements mentioned in this Section, see Section 16

SECTION 4. FIRST AID MEASURES

Description of first aid measures

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SECTION 4. FIRST AID MEASURES

Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes.
Immediate medical attention is required.

Skin Contact Wash off immediately with plenty of water for at least 15 minutes. Immediate medical attention
is required.

Ingestion Do not induce vomiting. Call a physician or Poison Control Center immediately.

Inhalation Move to fresh air. If breathing is difficult, give oxygen. Do not use mouth-to-mouth resuscitation
if victim ingested or inhaled the substance; induce artificial respiration with a respiratory
medical device. Immediate medical attention is required.

Notes to Physician Treat symptomatically

SECTION 5. FIRE-FIGHTING MEASURES

Extinguishing media

Suitable Extinguishing Media

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Extinguishing media which must not be used for safety reasons

No information available.

Special hazards arising from the substance or mixture

Thermal decomposition can lead to release of irritating gases and vapors

Advice for fire-fighters

As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective
gear. Thermal decomposition can lead to release of irritating gases and vapors.

SECTION 6. ACCIDENTAL RELEASE MEASURES

Personal precautions, protective equipment and emergency procedures

Ensure adequate ventilation. Use personal protective equipment. Avoid dust formation.

Environmental precautions

Should not be released into the environment.

Methods and material for containment and cleaning up

Sweep up or vacuum up spillage and collect in suitable container for disposal. Avoid dust formation.

SECTION 7. HANDLING AND STORAGE

Precautions for Safe Handling

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Use only under a chemical fume hood. Wear personal protective equipment. Do not get in eyes, on skin, or on clothing. Avoid ingestion
and inhalation. Avoid dust formation.

Conditions for safe storage, including any incompatibilities

Keep containers tightly closed in a dry, cool and well-ventilated place. Keep away from direct sunlight. Store under an inert atmosphere.

Specific End Uses

SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION

Control parameters

Exposure limits
Component Austria Denmark Switzerland Poland Norway
p-Aminophenol NDS: 5 mg/m3 8
godzinach

Component Latvia Lithuania Luxembourg Malta Romania

p-Aminophenol TWA: 1 mg/m3

Biological limit values This product, as supplied, does not contain any hazardous materials with biological limits
established by the region specific regulatory bodies.
Derived No Effect Level (DNEL) No information available.
Predicted No Effect Concentration No information available.
(PNEC)

Exposure controls

Engineering Measures Use only under a chemical fume hood Ensure that eyewash stations and safety showers are
close to the workstation location
Personal protective equipment
Eye Protection Goggles
Hand Protection Protective gloves
Skin and body protection Wear appropriate protective gloves and clothing to prevent skin exposure
Respiratory Protection Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN
149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits
are exceeded or if irritation or other symptoms are experienced

Hygiene Measures Handle in accordance with good industrial hygiene and safety practice
Environmental exposure controls No information available.

SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES

Physical State Solid

Appearance Beige
odor rotten-egg like

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SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES

pH No information available.
Vapor Pressure 0.4 hPa @ 110 °C
Boiling Point/Range 284°C / 543.2°F@ 760 mmHg
Melting Point/Range 187 - 191°C / 368.6 - 375.8°F
Decomposition temperature > 284°C
Flash Point 189°C / 372.2°F
Autoignition Temperature 250°C / 482°F

Water Solubility 15 g/L (20°C)

Molecular Formula C6 H7 N O
Molecular Weight 109.13

SECTION 10. STABILITY AND REACTIVITY

Reactivity

Chemical Stability

Sensitivity to light. Air sensitive.

Possibility of Hazardous Reactions

Hazardous Polymerization Hazardous polymerization does not occur.

Hazardous Reactions . None under normal processing..

Conditions to Avoid

Incompatible products, Excess heat, Avoid dust formation, Protect from light, Exposure to air.

Incompatible Materials

Strong oxidizing agents.

Hazardous Decomposition Products

Carbon monoxide (CO). Carbon dioxide (CO2). Nitrogen oxides (NOx).

SECTION 11. TOXICOLOGICAL INFORMATION

Information on Toxicological Effects

Acute Toxicity

Component Information
Component LD50 Oral LD50 Dermal LC50 Inhalation
p-Aminophenol 375 mg/kg ( Rat ) 10 g/kg ( Rabbit ) 5.91 mg/kg ( Rat ) 1 h

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Chronic Toxicity
Carcinogenicity There are no known carcinogenic chemicals in this product

Sensitization No information available.

Mutagenic Effects Substances which cause concern for man owing to possible mutagenic effects but for which
the available information is not adequate for making a satisfactory assessment
Reproductive Effects No information available.
Developmental Effects No information available.
Target Organs None known.
Other Adverse Effects See actual entry in RTECS for complete information
Endocrine Disruptor Information None known

SECTION 12. ECOLOGICAL INFORMATION

Toxicity

Ecotoxicity effects Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic
environment Do not empty into drains
Component Freshwater Algae Freshwater Fish Microtox Water Flea
p-Aminophenol Onchorhynchus mykiss: EC50 = 0.77 mg/L 30 min 200-280 mg/L 48h
LC50 = 1.2 mg/L 96h EC50 = 0.81 mg/L 15 min
EC50 = 0.91 mg/L 5 min

Persistence and degradability

Not readily biodegradable

Bioaccumulative potential

No information available.

Component log Pow

p-Aminophenol 0.04

Mobility in soil

Results of PBT and vPvB assessment

Other adverse effects

No information available

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SECTION 13. DISPOSAL CONSIDERATIONS

Waste treatment methods

Waste from Residues / Unused Dispose of in accordance with local regulations

Products

Contaminated Packaging Empty containers should be taken to local recyclers for disposal

SECTION 14. TRANSPORT INFORMATION

IMDG/IMO
UN-No 2512
Hazard Class 6.1
Packing Group III
Proper Shipping Name AMINOPHENOLS

ADR
UN-No 2512
Hazard Class 6.1
Packing Group III
Proper Shipping Name AMINOPHENOLS

IATA
UN-No 2512
Hazard Class 6.1
Packing Group III
Proper Shipping Name AMINOPHENOLS

SECTION 15. REGULATORY INFORMATION

Safety, health and environmental regulations/legislation specific for the substance or mixture

International Inventories

Component EINECS ELINCS NLP TSCA DSL NDSL PICCS ENCS CHINA AICS KECL
p-Aminophenol 204-616-2 - T X - X X X X X

Legend

TSCA - United States Toxic Substances Control Act Section 8(b) Inventory

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EINECS/ELINCS - European Inventory of Existing Commercial Chemical Substances/EU List of Notified Chemical
Substances
DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List
PICCS - Philippines Inventory of Chemicals and Chemical Substances
ENCS - Japan Existing and New Chemical Substances
CHINA - China Inventory of Existing Chemical Substances
AICS - Inventory of Chemical Substances
KECL - Existing and Evaluated Chemical Substances

Chemical Safety Assessment

SECTION 16. OTHER INFORMATION

Full text of R-phrases referred to under sections 2 and 3

R68 - Possible risk of irreversible effects
R20/22 - Harmful by inhalation and if swallowed
R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment

Revision Date 19-Apr-2012

Revision Summary
Reason for revision Not applicable
This safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006
Disclaimer
The information provided on this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date
of its publication. The information given is designed only as a guide for safe handling, use, processing, storage,
transportation, disposal and release and is not to be considered as a warranty or quality specification. The information
relates only to the specific material designated and may not be valid for such material used in combination with any other
material or in any process, unless specified in the text.

End of Safety Data Sheet

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