MoHP Protocol For COVID19 November 2020
MoHP Protocol For COVID19 November 2020
MoHP Protocol For COVID19 November 2020
CManagement
VID-19Protocol
Patients
in Hospitals
Page
Item
Number
Triage Protocol
4
Management Protocol
6
Gastrointestinal Manifestations
of COVID-19 15
Anticoagulation of COVID-19
Patients 16
Antibiotics in Covid-19 25
List of Editors 26
*Closed residential settings, humanitarian settings such as camp and camp-like settings for displaced persons.
NB: Minimal role for the epidemiological criteria during the period of community spread
Probable Case
A patient who meets clinical criteria AND is a contact of a probable or confirmed case,
or epidemiologically linked to a cluster with at least one confirmed case.
OR
Suspect case with chest imaging showing findings suggestive of COVID-19 disease*
OR
Recent onset of loss of smell or taste in the absence of any other identified cause
OR
Unexplained death in an adult with respiratory distress who was a contact of a probable
or confirmed case or epidemiologically linked to a cluster with at least 1 confirmed case
*Hazy opacities with peripheral and lower lung distribution on chest radiography; multiple bilateral ground
glass opacities with peripheral and lower lung distribution on chest CT; or thickened pleural lines, B lines, or
consolidative patterns on lung ultrasound.
Confirmed Case
A person with laboratory confirmation* of COVID-19 infection, irrespective of clinical signs
and symptoms
*Molecular testing(PCR) with deep nasal swab is the current test of choice for the diagnosis of acute COVID-19
infection
During seasonal flu period, clinical differentiation between influenza and COVID 19 is difficult.
Swab for influenza A &B may help in early differentiation.
Severity assessment
Suspected case
No Yes
In severe and critically ill patients, if-ve 1st PCR, repeat within 48 hours, negative case is considered after 2 –ve
consecutive RT-PCR results from respiratory samples tested at least 1 day apart.
NB: Unstable patient who don’t meet the suspected criteria should receive 1st aid therapy in non-COVID area
before referral to general hospital.+ Risk factors include, old age > 60 years, uncontrolled comorbidity as hyperten-
sion, DM, ……. or Social un applicable to home isolation.
All patients with symptomatic COVID-19 and Check Every Patient For Risk
risk factors for severe disease should be closely Factors
monitored. The clinical course may rapidly . Age 65 years
progress in some patients. . SpO2 < 92%
Antibiotics are not recommended to prevent . Heart Rate ≥110
bacterial infection in mild patients. Administer . Respiratory Rate ≥ 25 /min.
empiric antibiotics if bacterial . Neutrophil / lymphocyte ratio on
pneumonia/sepsis strongly suspected; re-evaluate CBC ≥ 3.1
daily. . Uncontrolled Comorbidities
In non-hospitalized patients, do not initiate . On Immunosuppressive or
therapeutic anticoagulants or antiplatelet chemotherapy drug
unless other indications exist. . Pregnancy
No harmful effect for administration of vitamin . Active Malignancy
C or D or Zinc or Lactoferrin within the required . Obesity (BM>40)
daily dose.
Time is an important issue in management of COVID-19. Before day 12( stage of viral
load), Antiviral drug is essential. After day 12, the role of antiviral declines with
augmentation for the role of anti-inflammatory, immune-modulators and Supportive drugs
(stage of hyper-immune state).
Potential antiviral drugs under evaluation for the treatment of COVID-19 include:
- Hydroxy Chloroquine 400mg/ 12 hours 1st day followed by 200 mg/12 hours for 6 days,
- Ivermectin 6 mg (36 mg on day 0 -3-6),
- Favipiravir 1600 twice daily first day then 600 mg twice daily,
- Remdesivir 200 mg IV on day 1, followed by 100 mg IV daily for high risk population for 5
days that could be extended to 10 days if the response is unsatisfactory or
- Lopinavir/Ritonavir 200/ 50 mg 2 tablets PO BID
- Monoclonal antibodies:
antibodies early testing in blocking SARS-CoV-2.
- Convalescent plasma:
plasma for impending severely ill after counseling the scientific committee
Mild illness
Home isolation and symptomatic treatment (eg, antipyretics for fever, adequate nutrition,
appropriate rehydration).
Educate the patients on signs/symptoms of complications that, if developed, should prompt
pursuit of urgent care.
There are insufficient data to recommend either with or against any antiviral or im-
mune-based therapy in patients with COVID-19 who have mild illness.
IS IT A FLU OR COVID-19?
SYMPTOM FLU COVID-19
FEVER
FATIGUE
COUGH
SORE THROAT
HEADACHES
RUNNY NOSE
SHORTNESS OF BREATH
BODY ACHES
DIARRHEA AND/OR
VOMITING
ONSET 1-4 days after infection About 5 days after infection but can range
from 2-14 days
SKIN RASHES
All patients with symptomatic COVID-19 and risk factors for severe disease should
be closely monitored. In some patients, the clinical course may rapidly progress.
Check for
1. Age 65
2. Temperature > 38
3. SaO2 ≤ 92%
4. Heart Rate ≥ 110
5. Respiratory Rate ≥ 25 /min.
6. Neutrophil / lymphocyte ratio
All No on CBC ≥ 3.1 Any YES
7. Uncontrolled Comorbidities
8. Immunosuppressive Drug
AND 9. Pregnancy OR
10. Active Malignancy
11. On Chemotherapy
12. Obesity (BMI>40)
Age < 65 Age ≥ 65
Treatment
Immune-modulators
Anti-virals Anti-coagulation
Anti-inflammatory
Severe cases
RR > 30, SaO2 < 92 at room air, PaO2/FiO2 ratio < 300, Chest radiology showing more than
50% lesion or progressive lesion within 24 to 48 hrs.
Anti-coagulant Convalescent
Anti-virals Anti-inflammatory
Prophylactic plasma
anticoagulation if Steroids Before day 12
Remdesivir (Dexamethasone 6
D-Dimer between
or mg or methyl (under clinical trial)
500 -1000
Lopinavir/ prednisolone (1 mg / (after scientific
Therapeutic
Ritonavir kg /24 hours) committee
anti-coagulation if
D-dimer > 1000 approval)
Or if severe Tocilizumab
hypoxia 4-8 mg/kg/day for 2
doses 12 to 24 hours
apart after failure of
steroid therapy to
improve the case for
24 hours
Steroids
Remdesivir (Methyl prednisolone 2mg /kg or its
or Therapeutic equivalent)
anti-coagulation
Tocilizumab
Lopinavir/ 4-8 mg/kg/day for 2 doses 12 to 24 hours
Ritonavir apart after failure of steroid therapy to
improve the case for 24 hours
Early Block
the storm Tocilizumab
if steroids 4-8mg/kg/dose
failed 2 doses
Don’t wait
Add 1 mg for non Consider Improves too much for
Antibiotics ventilated D-dimer level V/Q matching any type of
As per and 2 mg for as a guide and survival support Keep
protocol ventilated plateau<30
High flow nasal oxygen is an important modality in the early management of critically ill patients.
(HFNC):
Conscious patients with minimal secretions.
Hypoxia SpO2 < 90% on oxygen. Or PaCO2 >40 mmHg provided pH 7.3 and above.
NIV trial shall be short with ABG 30 minutes apart.
Any deterioration in blood gases from baseline or oxygen saturation or consciousness
level shift to IMV.
CPAP gradually increased from 5-10 cmH2O.
Pressure support from 10-15 cm H2O.
HFNC can be alternative to NIV.
Type L Type H
Type L and Type H patients are best identified by CT scan and are affected by different
Pathophysiological mechanisms. If CT not available, definition could be used as surrogates:
Respiratory system elastance and recruitability.
Understanding the correct pathophysiology is crucial to establishing the basis for appropriate
treatment.
VCV
TV 8 ml/kg
PEEP 5 cmH2O
Plateau
Pressure Inspiratory Pause for 1 second
- ARDSNet protocol:
Plateau
P<30 cmH2O
LOW TV Incremental
6-4 ml/kg PEEP Driving
P<15 cmH2O
Assess
ABGs, Clinical
Radiological
- Gastrointestinal (GI) symptoms are seen in patients with COVID-19. The preva-
lence could be as high as 50%, but most studies show ranges from 16% to 33%
- Some patients with COVID-19 have presented with isolated GI symptoms that may
precede the development of respiratory symptoms
- It is important to note that medications used for COVID-19 may be associated with
GI symptoms as well.
- The antidiarrheal agent loperamide can be used in an initial dose of 4 mg and with
a maximum daily dose of 16 mg in patients without fever, bloody stools, or risk fac-
tors for C. difficile infection
Yes No
No Yes
Prophylactic dose
Therapeutic dose
Higher than standard
dose
0.5 mg/kg/m
70
Velocity (m.sec-1)
60
HVNI
50
40
30
HFNC
20
10
0
10 20 30 40 50 60
In short, “Despite their illness being ‘over,’ they are having a lot of
trouble returning to normal life.” It occurs in around 10% of patients.
Patients can be divided into those who may have serious sequelae (such as
thromboembolic complications) and those with a non-specific clinical pic-
ture, often dominated by fatigue and breathlessness. One last group of
covid-19 patients whose acute illness required intensive care management.
Management:
Medical management:
Self-management:
1-Daily screening of health care workers and patients before entering the
health care facility (HCF) based on clinical signs (fever, respiratory symp-
toms…….).
3- All health care workers are required to wear surgical masks during work
hours (during existence in HCFs).
4- Minimal number of health care workers should be present at the same time
in patient’s units to keep social distancing
6- Suspected or confirmed cases should take a separate route from other pa-
tients beginning from the facility entrance (Triage area), and all facility sec-
tions should follow the same separation.
• Hand hygiene
• Cough etiquette.
• Personal protective equipment.
• Clean and disinfected Environmental surfaces.
• Sterile instrument and devices
• Sharp safety.
• Isolation transmitted precaution.
• Safe injection practices.
Recommendations
According To The Type Of Procedure
• Standard precautions.
1- Surgical mask.
5- Health care worker are not required to wear protective boots and protective
suits during routine care of cases.
6- Extended use of surgical masks, gowns, eye protectors, and face shields can
be applied while caring for COVID-19 patients in the event of a shortage of
personal 2 protective equipment for the length of the work shift (preferably
not more than six hours).
7- Always remember not to touch the eyes, mouth or nose with contaminated
hands or used gloves (wash your hands or rub using alcohol when touch any
environmental surface).
• Tracheal intubation .
• Tracheotomy.
• Cardiopulmonary resuscitation.
• Standard precautions.
- The extended use of a mask, medical gown, eye goggles, or face shield
(Extended use) can be applied while caring for patients with COVID-19 in the
event of a lack of personal protective equipment and for the length of the work
shift (preferably no more than six hours).
- Care must be taken not to touch the eyes, mouth or nose with contaminated
bare hands or using gloves (wash your hands or rub using alcohol when touch
any environmental surface).
ANTIBIOTICS IN COVID-19
Indications:
Low-risk inpatients:
- Combination therapy:
β-lactam (eg, ceftriaxone, or cefotaxime) plus either a macrolide
(eg, azithromycin or clarithromycin) or doxycycline.
- Monotherapy:
Respiratory fluoroquinolone (eg, levofloxacin or moxifloxacin)
High-risk inpatients:
NAME AFFILIATION
NAME AFFILIATION