1117

ORIGINAL ARTICLE
Impact of ethanol, dry care and human milk on the time for umbilical cord separation
Mohammad Golshan, Nematizadeh Hossein

Abstract
Objective: To compare the extraction time and infection rate of umbilical cord by applying ethanol, humanmilk or
dry care.
Method: The parallel single-blinded randomised clinical trial was performed on 300 neonates at Shahid Sadougi
University of Medical Sciences and Health Service, Yazd, Iran, between March and September 2010. The neonates
were divided into three random but numerically equal groups. Each group was assigned the application of ethanol
or mother’s milk or to keep the stump dry. The neonates were visited on the 3rd and the 7th day after birth and
follow-up was maintained telephonically until umbilical separation. Umbilical separation time and umbilical local
infection frequency were considered as the study outcome, which was compared among the three groups
according to age, gender and delivery type of the neonates.
Results: Umbilical separation time in neonates of the human milk group had significant difference with the ethanol
group (p=0.0001) and drying groups (p=0.003). Frequency of omphalitis had no significant difference among the
three groups.
Conclusion: Topical usage of human milk on umbilical cord stamp decreased separation time and incidence rate of
omphalitis.
Keywords: Umbilical cord, Human milk, Ethanol, Dry care, Separation time. (JPMA 63: 1117; 2013)

Introduction leukocytes or polymorphonuclear cells. Neonates who used

One million neonates die due to umbilical cord infection. human milk had lower umbilical extraction time compared
Most of these mortalities occurr in developing countries. to those who used antiseptic solutions.2 The present
According to a recent World Health Organisation (WHO) randomised clinical trial was conducted to compare the
report 300,000 neonates die annually due to tetanus impact of three therapeutic methods human milk, drying
infection, and umbilical cord is the leading route for such and ethanol 70% on the separation of umbilical cord.
an infection.1,2
Patients and Methods
Umbilical cords converts into necrotic tissue and becomes During the study period between March and September
a suitable media for infection pathogens in the 2010, all healthy term (37-42 weeks) neonates (n=316)
environment. Staphylococcus aureus, Escherichia coli and were included in the trial at Shahid Sadoughi Hospital of
streptococcus in group B are common pathogens.1 Using Shahid Sadoughi University of Medical Sciences and
anti-bacterial treatments in neonatal umbilical cord are Health Services. The study was approved by the
associated with lower bacterial penetration, but reduce institutional ethics committee, and informed consent was
leukocytes secretion which are needed for umbilical cord obtained from the parents of each neonate. The inclusion
extraction. Delay in the extraction can increase umbilical criteria comprised neonates who were delivered with
infection.1,3 According to complications related to different normal vaginal or Caesarean section and healthy term
methods of extraction, WHO recommended drying of neonates with 37-42 weeks gestational age and without
umbilical cord as a suitable method. Though several other medical complications or disorders such as
studies have supported this recommendation,1,4 there are maternal abnormalities or respiratory distress, asphyxia,
contradictory statements about this method as well.2 or metabolic disorders. Age, gender, delivery type and
complications were recorded in the checklist.
Human breast milk is considered a better management
practice and is used in some countries.2 Human milk can The neonates were divided into three groups [ethanol
accelerate complex umbilical extraction according to its topical human milk] randomly with the help of the
numbers table. Age and gender of the neonates were
matched. In the ethanol group, mothers washed the
Department of Paediatric, Shahid Sadoughi University of Medical Sciences and umbilical stump with 70% ethanol two times a day for two
Health Services, Yazd, Iran. days after umbilical separation. In the milk group, mothers
Correspondence: Mohammad Golshan. Email: [email protected] washed the umbilical cord stump with their milk two times

Vol. 63, No. 9, September 2013

M. Golshan, N. Hossein 1118
a day for two days after umbilical separation. In the third Table-2: Mean of umbilical separation days.
group, mothers only dried the umbilical stump until
umbilical separation. Neonates were visited on the 3rd and Study Mean Standard Confidence P-value
group deviation interval
the 7th day in hospital after birth, and were followed up
through telephone after one week until umbilical Maternal milk 6.5 1.93 6.12 - 6.88
separation. Neonates whose umbilical cords were not Drying 7.54 2.37 7.07 - 8.01 0.001
separated during the first week of life were followed up Ethanol 8.94 2.39 8.47 - 7.94
until its separation. Omphalitis symptoms, such as
infectious discharge or circular erythema or rigidity around
the umbilicus or in the anterior of the abdomen, were kept the eligibility criteria or parents declined to participate. The
an eye on. Umbilical separation time and umbilical local final sample size as such 300. In the assessment of basic
infection frequency were considered as the study outcome, variables, none had significant difference among the three
which was compared among the three groups according to groups. The mean of maternal age, number of pregnancies
age, gender and delivery type of the neonates. neonatal weight and gestational age also had no significant
differences, (Table-1).
Data was analyzed through SPSS 16. Quantitative
variables were presented as mean and standard The mean of umbilical separation time had significant
deviation, while qualitative variables were presented as differences among the three groups (p <0.0001). The
frequency and percentage. Umbilical separation time was lowest and the highest separation times belonged to
taken as quantitative, and frequency of omphalitis as a human milk and ethanol groups respectively. Among the
qualitative variable among the neonates of the three neonates, the lowest and the highest umbilicus
groups for the purpose of Fisher Exact test and analysis of separation times were 3 and 15 days. In post hoc analysis,
variance (ANOVA) tests. Two-tailed significance level of umbilical separation time in human milk group had
0.05 was used to detect difference between the variables. significant differences with ethanol (p <0.0001) and
drying groups (p <0.003), (Table-2).
Results
The initial Primary study population was 316, but 16(5.06%) The frequency of omphalitis did not have significant
neonates had to be excluded: 10(3.16%) for not meeting differences among the three groups. We had only 1(1%)
neonate in the drying group and 2(2%) neonates in the
Table-1: Variables between neonates of three groups. ethanol group, while there was none in the human milk
group with omphalitis. Mothers of 4(4%) neonates in the
Mean Standard P-value human milk group, 3(3%) neonates in the ethanol group
deviation
and 3(3%) neonates in the drying group were using
Maternal age (years) Maternal milk 26.28 5.52 0.53
antibiotics. There were no significant differences among
Drying 26.55 5.60 the three groups, on this count.
Ethanol 25.69 5.30
Number of pregnancy Maternal milk 2.07 1.46 0.29 Discussion
Drying 1.87 1.04 The present study showed that the mean of umbilical
Ethanol 1.81 1.14 separation time had significant difference among the
Neonatal weight Maternal milk 3046.20 314.26 0.79 three groups. Umbilical separation time in neonates of the
Drying 3045.20 331.24 human milk group had significant differences with the
Ethanol 3017.70 358.19 other two groups. A study on 312 neonates who received
Gestational age (weeks) Maternal milk 38.87 0.93 0.19 ethyl alcohol, human milk, silver sulfadiazine and drying
Drying 38.59 0.96
method for clearing and drying of the umbilical cord,
Ethanol 38.81 0.87
Qualitative variables
reported that the mean of separation time in the human
Male neonates (N,%) Maternal milk 47 47 0.62 milk group was significantly lower than the other groups,
Drying 54 54 and increased respectively in alcohol, drying and silver
Ethanol 51 51 sulfadiazine groups. Omphalitis was not seen in any of the
Vaginal delivery Maternal milk 49 49 0.61 neonates.3
Drying 52 52
Ethanol 56 56 Another study on 77 neonates reported that Escherichia
Antibiotic usage Maternal milk 4 4 0.90 coli and Streptococcus group B colonisation in the
Drying 3 3 umbilical cord stamp in neonates who received drying
Ethanol 3 3 was significantly higher than those who received ethanol

J Pak Med Assoc

1119 Assessment impact of ethanol, dry care and human milk on time of umbilical cord separation

70%. The mean of umbilical cord separating time had no infiltration between the umbilical cord stump and the
significant difference between the two groups.5 A study abdominal wall. Human milk accelerates umbilical cord
on 118 neonates in two groups of human milk and drying separation process because it has polymorphonuclear
for colonisation of pathogen and non-pathogen and photolytic enzymes.3
organisms showed that pathogen organisms colonised
significantly lower in neonates who received topical Conclusion
human milk in their umbilical cord against the non- The use of human milk as topical therapy can decrease
pathogen organisms. The mean of separation time of the separation time in neonates compared other methods.
umbilical cord was significantly lower in neonates with This can be used as a suitable, safe and non-expensive
topical human milk.1 In the light of to above studies, it method for umbilical cord management.
seems that in developing countries, health policy of
umbilical cord drying needs more assessments. References
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According to WHO recommendations, some factors like Ghazvini K. Dose topical application of breast milk affect on
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separation.6 Topical antiseptic usage on the stump of human milk, povidone-iodine and dry care. J Obster Gynecol
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Vol. 63, No. 9, September 2013