Aspirin Drug Study
Aspirin Drug Study
aspirin Inhibits cyclo- Analgesia, Fever Occasional: GI Alcohol, NSAIDs may Do not give to
as-pir-in oxygenase enzyme Revascularization distress (including increase risk of GI children or teenagers
PHARMACOTHERAPEUTIC: via acetylation. MI, Stroke (Risk abdominal effects (e.g., who have or have
Nonsteroidal salicylate. Inhibits formation of Reduction) distention, cramping, ulceration). recently had viral
CLINICAL: Anti- prostaglandin heartburn, Antacids, urinary infections (increases
inflammatory, antipyretic, derivative mild nausea); allergic alkalinizers increase risk of Reye’s
anticoagulant. thromboxane A. reaction (including excretion. syndrome). Do not
aspirin or Ascriptin with Therapeutic Effect: bronchospasm, Anticoagulants, (e.g. use if vinegar-like
Afrin, Aricept, or Ecotrin Reduces pruritus, urticaria). enoxaparin, odor is
with Epogen inflammatory warfarin), heparin, noted (indicates
response, intensity Adverse effects/toxic thrombolytics, chemical
of pain; decreases reactions rivaroxaban, breakdown). Assess
fever; inhibits High doses of aspirin ticagrelor history of GI bleed,
platelet may produce GI increase risk of peptic ulcer
aggregation. bleeding and/or bleeding. disease, OTC use of
gastric mucosal products that may
lesions. contain aspirin.
Dehydrated, febrile Assess type, location,
children may duration of pain,
experience aspirin inflammation.
toxicity quickly. Inspect appearance
Reye’s of affected joints for
syndrome, immobility,
characterized by deformities, skin
persistent vomiting, condition.
signs of brain Therapeutic serum
dysfunction, may level for
occur in children antiarthritic effect:
taking aspirin with 20–30 mg/dL
recent viral infection (toxicity occurs if
(chickenpox, level is greater than
common 30
cold, or flu). Low- mg/dL).
grade aspirin toxicity
characterized by
tinnitus, generalized
pruritus (may be
severe), headache,
dizziness, flushing,
tachycardia,
hyperventilation,
diaphoresis, thirst.
Marked toxicity
characterized by
hyperthermia,
restlessness,
seizures, abnormal
breathing patterns,
respiratory
failure, coma.