SANUM

Allergic Diseases

Therapy Concepts with

SANUM Remedies
Dr. rer. nat. Petra Grüning,
Naturpath
 Content

• Short Introduction
• Types of Allergies
• Development of Allergies
• Link between Allergy and Gut
• Therapy Scheme for Hay Fever
• Therapy Scheme for Neurodermatitis

2
 Widespread Disease Allergy
• 22% of the world population suffer from hay fever
• 235 million asthma patients worldwide
• in Germany ~30% of the population suffers from
allergic diseases (2013)
– 23% of children (0-17 years) have atopic allergies (KIGGS
study, 2014)
• 13% neurodermatitis
• 11% hay fever
• 5% bronchial asthma
• Likely a high number of unreported cases
• 10% allergic contact dermatitis
• 20% food allergies
• 41% allergic sensitization to at least one antigene
Source: Allergy research in Germany 2008., Bundesgesundheitsblatt 2014, 57:771-778

3
 Allergy - Definition
Allergy
allos = different and ergon = effect, reaction

• The body reacts differently or hypersensitive to a

specific substance (allergen), which is usually not
harmful
• Inflammatory processes (often chronic) at the
boundaries of the human organism:
 skin
 respiratory tract
 intestines (bowels)

4
 Allergens
• Wide range of allergy triggers
 pollen from shrubs, trees and grasses
 animal hair
 dust mites
 food allergens like milk, eggs, different types of
grains, nuts, fruits, …
 insect poison
 medicinal products, preservatives, pesticides
 nickel, latex
 …..

5
 Types of Allergens
Classification of allergens in four groups:
• Inhalation allergens
 e.g. pollen, fungal spores
• Ingestion allergens
 food allergens, e.g. dairy products, strawberries
• Contact allergens
 e.g. nickel, latex
• Injection allergens
 animal poisons like bee venom, snake venom
 procaine, X-ray contrast medium

6
 Allergic Reactions –
Allergic Reaction Type 1 (immediate type)

• First allergen contact

 initial sensitisation phase
 formation of IgE antibodies
 binding of circulating IgE antibodies
to mast cells
• Renewed allergen contact
 antigen-antibody reaction
 release of histamine

7
 Allergic Reactions –
Allergic Reaction Type I (immediate type)

• Within seconds to minutes allergic symptoms occur

 itching
 sneezing, nasal discharge
 edemas
 hypotension and constriction of the airways, at
worst leading to
 anaphylactic shock

8
 Allergic Reaction Type II (cytotoxic
hypersensitivity reaction)
• IgM- or IgG-antibodies bind to cell-mediated antigens
 activation of
 cytotoxic killer cells
 complement system
 after hours or a few days the antigen carrying cells
are dissolved
• Examples for a cytotoxic hypersensitivity reaction are:
 some haemolytic anaemia
 agranulocytosis
 (transplant rejection)

9
 Allergic Reaction Type III
(immune complex type)
• Deposition of circulating immune complexes in/on
joints and/or different tissues, often close to blood
vessels
 unknown cause
 activation of complement system with subsequent
tissue damage
• Examples:
 allergic alveolitis
 medication allergy
 systemic lupus erythematosus
 immuno-complex glomerulonephritis
 e.g. after streptococcal infection
10
 Allergic Reaction Type IV
(delayed reaction type)
• Sensitization of T-lymphocytes after first allergen
contact
• After renewed allergen contact, different cytokines
are released by T-lymphocytes
 activation of macrophages with subsequent tissue
damage
• Delayed reaction
 1-3 days after allergen contact
• Examples:
 contact allergy to nickel, latex, plants etc.
 transplant rejection

11
 Pseudoallergy
• Reaction to allergen– without sensitization
 the allergen seems to act directly on the mast cells
• No clinical distinction to a „normal“ allergy
 like an allergic reaction type I (immediate type)
• common trigger
 medicines
 food additives

12
 Cross-Sensitivity

• Conformity with the molecular proteine structure of

an antigen causes an allergic reaction even without
previous contact
• e.g. pollen associated food allergy
 Sufferers from birch pollen allergy often can‘t
tolerate:
 nuts
 fruits of rosaceous plants like apples, pears
 mugwort is a chief allergen for herb and spice
allergies

13
 Development of Allergies I
• Multifactorial process
• Risk factors for allergy developement:
 genetic disposition

14
 Development of Allergies –
Gentic Disposition
% of children who develop an allergic disease

60-80%
both parents with same allergic
disease

40-60%
both parents with allergy

20-40%
single parent with allergy

5-15%
both parents no allergy

0% 10% 20% 30% 40% 50% 60% 70%

www.allergiecheck.de

15
 Development of Allergies I
• Multifactorial process
• Risk factors for allergy development:
 genetic disposition
 application of antibiotics in early life and during
pregnancy
 birth via caesarean section
 formula milk
 lack of animal contact during pregnancy and the
first years of life

16
 Development of Allergies II
The foundation for the development of allergies is laid
during infancy already.

The intestinal flora is influenced by:

• Application of antibiotics
 during pregnancy
 in early life
• Birth via caesarean section
 bacterial miscolonisation with skin and
environmental flora
• Artificial formula milk/nutrition

17
 Gut Ecosystem – Development
• Development of the gut microbiome is a multifactorial
process:
 diversity of bacteria evolves until the age of 3 - 4
 nutrition
 treatment of mother and child
 environment
• Intact microbiome
 development of the immune and nervous system
 approx. 70% of the immune system
 significant influence on physiological, metabolic and
psychological processes in the body

18
 Immune System ↔ Microbiota
• Constant interaction of immune cells and microbiota/
commensals
 important for maintenance of homeostasis
• An active immune response against commensals
appears to be linked to the development of the
disease
• Without commensals, no tolerance for food and
ingested antigens can evolve
 tolerance: supression of an inflammatory immune
response

19
 Gut Microbiota ↔ Disease
There ist a link between a reduced diversity of gut flora
and the early onset of inflammatory diseases:
 atopy
 eczema
 asthma
 obesity
Patients with a dysbioses in the intestines often suffer
from:
 allergies
 diabetes type I
 inflammatory bowel diseases (e.g. ulcerative
colitis and Crohn's disease)
20
 Dysbioses of Microbiota
• Insufficient supply to intestinal epithelium
→ increased permeability ↑ (leaky gut
syndrome)
 intestinal inflammation
• Impairment of gut immunoregulatory
mechanisms
• ↓ Bifidobacteria
 enhance intestinal barrier function
 inhibit inflammation
• ↓ Diversity of gut flora

21
 Aim of the Treatment

• Stop inflammation
• Milieu restoration of the
intestine
• Immune-modulation
Therapy Concepts
allergic rhinitis atopic eczema
- -
hay fever neurodermatitis

22
 Principals of SANUM Therapy
Four-step Protocol
• Milieu regulation
• Isopathic degradation of pathogenic
growth forms
• Elimination of pathogenic, cell-wall
deficient bacteria (CWD) with
SANUKEHL® - remedies
• Modulation of the immune system
• Removal of toxins and metabolic
waste

23
 Immune-Modulation
Immune-modulation/stimulation - definition according to
Hänisch (1986)
„Non-specific substances (e.g., organ and bacterial
preparations) which do not themselves elicit immune
responses, but support a specific immune response."

• Stimulation of IgA, IgG secretion

• Modulation of cytokine production, e.g. TNF-α, IL10
• Proliferation of B- and T-lymphocytes

24
 Change of Diet

Preferably food low in allergens, omitting:

– Products made
from cow's milk Dr. Werthmann‘s diet
– Hen‘s eggs
– Pork

– Products containing gluten

– Soy
– Nuts

25
 Restoration
of the Intestinal Flora
1. Milieu regulation: SANUVIS®, CITROKEHL®, ALKALA® N
and ALKALA® S
2. Specific regulation: FORTAKEHL® 5X drops for 14 days
(2x 2-8 daily)
3. General regulation: SANKOMBI® 5X drops for at least 4
weeks (2x 2-8 daily)
4. Immune-modulation: begin with step 3 - UTILIN® 4X/6X
capsules for 5 weeks (1x 1 weekly)

26
 Allergic Rhinitis
• A chronic, lgE-induced inflammatory disease of the nasal
mucous membranes
 predominantly inhalation allergens (e.g. pollen, dust mites)
 seasonal (hay fever)
• Symptoms:
• increased lacrimation, sometimes conjunctivitis
• itching
• sneezing
• rhinorrhea
• impaired nasal breathing
• dyspnea
• fatigue, depressive mood, anorexia

27
 SANUM Therapy for Hay Fever I
Recommended duration of therapy is approx. 6-8 weeks.
Administration forms, treatment intervals and duration may be altered if required. Dosage for adults.

1. milieu-regulation throughout the entire treatment

change of diet, restoration of the intestinal flora

ALKALA® N powder 1x 1 measuring spoon daily, in hot water in

the evening, after 14 days switch to ALKALA® S powder
1-2x 1 tea spoon in water during a meal.
in the morning SANUVIS® drops 1x 60 daily
in the evening FORMASAN® drops 1x 5-10 daily
in the evening ZINKOKEHL® 3X drops. 1x 10 daily
LUFFASAN® drops 1-3x 5-10 daily

28
SANUM Therapy for Hay Fever II

2. specific regulation begin simultaneously with stage 1

over a period of 10-14 days

in the morning FORTAKEHL® 5X drops 1x 2-8 daily,

in the evening RUBERKEHL® 5X drops. 1x 5-10 daily,
start in low doses;

following this, stage 3 and 4 begin at the same time:

29
 SANUM Therapy for Hay Fever III
3. general regulation over a longer period
(4-6 weeks)
Monday - Friday:
in the morning MUCOKEHL® 5X drops,
in the evening NIGERSAN® 5X drops,
each 1x 2-8, start with a low dosage
or
morning and evening SANKOMBI® 5X drops, 2x 2-8 daily

Saturday/Sunday: remedies of stage 2

30
SANUM Therapy for Hay Fever IV
4. Immune-modulation simultaneously with stage 3
(several weeks)

weekly UTILIN ® 4X/6X capsules, 1x ½-1 per week

or LATENSIN® 6X capsules, RECARCIN® 6X capsules and
UTILIN® 4X/6X capsules in weekly alternation, 1x ½-1 capsule
each per week

SANUKEHL® remedies in daily alternation, depending on

symptoms or pathogen (e.g. Pseu, Myc 6X drops) 1x 1-4
rubbed in and 1x 1-4 taken orally
always begin with a low dosage

31
Immune Modulators for Hay Fever

Remedy Bakteria/Organ Application according to

experience
LATENSIN® Bacillus cereus chronic inflammation of the
respiratory tract, digestive tract
and the skin
RECARCIN® Bacillus firmus subacute, chronic inflammation of
the glands and serous membranes
UTILIN® Bacillus subtilis subacute, chronic inflammations,
functional intestinal disorders,
liver, gall bladder

32
 LUFFASAN®
Luffa operculata:
annual, fine creeping plant belonging to the
familiy of cucurbits (Cucurbitaceae)
kidney or heart shaped leaves with pale yellow
blossoms in the leaf axils
plum-sized fruit, armed with thorns
H. Zell, www.wikipedia.de
found in the entire South American area
LUFFASAN®
• produced from the dried fruits
Application areas, according to experience:
• diseases in connection with a runny nose and an allergic
rhinitis
• supportiv in cases of edema, congestion and all stases
brought on by inflammations
• for excretion, especially in stases

33
 LUFFASAN® 4X Drops and Tablets
Active ingredient:
dried ripe fruits of Luffa operculata 4X
Administration form:
tablets and drops
Dosage
tablets
 acute: 1 tablet up to 6x daily
 chronic: 1 tablet 1-3x daily
drops
 5-10 drops 1-3x daily

34
 RUBERKEHL®
• Active ingredient: Aspergillus ruber in preparation
according to HAB (German Homeopathic Pharmacopeia)
Application according to experience (i.a.):
 runny nose
 sinusitis
 conjunctivitis
• Administration form:
drops, ampoules and suppositories
• Dosage: Aspergillus ruber, EM-Aufnahme

drops (5X) 1x 5-10 daily

ampoules (5X) 1 amp. twice a week
suppositories (3X) 1x 1 suppository daily
35
 Study on the Antiallergenic Effect of
RUBERKEHL®
• 2-3 injections i.m. weekly, duration of study 4 weeks
Symptoms of hay fever beginning - end

blocked nose

runny nose
lacrimation

dispnea

itching of eyes

redness of eyes
coughing

sneezing
0 5 10 15 20 25 30

beginning end number of patients

reference: J. Hartmann, SANUM Post

25/1993 36
 Atopic Dermatitis - Neurodermatitis
• Chronic inflammatory skin disease, partially
accompanied by intense itching
• Often begins in infancy
 10 to 15% of preschoolers are affected
• Elevated IgE-levels in serum, triggered by inhalation,
contact and ingestion allergens
• Symptoms
 generally dry skin, with reddened inflamed areas (eczema),
often very itchy
 complications through skin infections
 laminar swelling and coarsening of the skin (lichenification)
 nodules and pustules

37
SANUM Therapy for Neurodermatitis I
Recommended duration of therapy is approx. 6-8 weeks.
Administration forms, treatment intervals and duration may be altered if required. Dosage for adults.

1. Milieu Regulation throughout the entire treatment

Change of diet, restoration of the gut flora

ALKALA® N powder 1x 1 measuring spoon in hot water daily in the

evening, after 14 days, switch to ALKALA® S powder
1-2x 1 teaspoon in water with a meal
morning SANUVIS® drops 1x 60 daily
evenig FORMASAN® drops 1x 5-10 daily
morning SELENOKEHL® 4X drops 1x 10 daily
evening ZINKOKEHL® 3X drops 1x 10 or ZINK+BIOTIN caps. (Biofrid)
1x 2 daily
EVENING PRIMROSE OIL capsules (Biofrid) 2x 1 daily
HEXACYL® drops 1-3x 5 daily

38
SANUM Therapy for Neurodermatitis II

2. Specific Regulation begin simultaneously with stage 1

for 10-14 days

morning FORTAKEHL® 5X drops 1x 2-8

evening NOTAKEHL® 5X drops (in cases of bacterial super
infections) and/or PEFRAKEHL® 5X 1x 2-8 (in cases of fungal
burden),
begin with a low dosage;
(alternatively: EYMYKEHL® 5X drops 1x 2-8
or EYMYKEHL® 3X suppositories 1x 1 in the evening

this is followed by stage 3 and 4 simultaneously:

39
SANUM Therapy for Neurodermatitis III
3. General Regulation for a longer period (4-6 weeks)
Monday - Friday:
morning and evening SANKOMBI® 5X drops, 2x 2-8 daily
Saturday/Sunday: remedies of stage 2

4. Immune modulation begin simultaneously with stage 3

(several weeks)
daily REBAS® 6X capsules 1x ½-1
weekly UTILIN® 4X/6X 5 capsules, 1x ½-1 per week
or RECARCIN® 6X capsules and UTILIN® 4X/6X capsules in weekly
alternation, 1x ½-1 capsule each per week
SANUKEHL® remedies in daily alternation, depending on the
symptoms or pathogen (e.g. Pseu, Myc 6X drops) 1x 1-4 rubbed in
and 1x 1-4 taken orally
allways begin with a low dosage

40
 Immune-Modulators for
Neurodermatitis
Remedy Bacteria/Organ Application according to experience
RECARCIN® Bacillus firmus subacute, chronic inflammation of
the glands and serous membranes
UTILIN® Bacillus subtilis subacute, chronic inflammations,
functional intestinal disturbances,
liver, gall bladder
REBAS® Peyer’s patches chronic, recurring inflammations,
stomach-gut diseases, disturbances
in the humoral defense

41
 Support with Phytotherapy
• chronic eczema with moderate inflammation
– Evening primrose oil in ointments or lotions (Didier®
Nachtkerzen-Vitamin E Lotion with evening primrose oil,
vitamin E, hamamelis and allantoin, Biofrid company)
– Balloon plant (Cardiospermum halicacabum) mother tincture in
ointments or lotions
• very dry, inflamed skin
– almond oil
– sea buckthorn kernel oil
sea buckthorn
• Substitution of γ – linolenic acid www.wikipedia.de

– Evening primrose oil internally and externally

(NACHTKERZENÖL capsules and lotion, Biofrid company)
• intense itching
– compresses of plants containing tanning acids, such as black
tea, oak bark extract
42
evening-primrose (Oenothera biennis) ballon plant (Cardiospermum halicacabum)

reference: www.wikipedia.de

43
 SANUM Excretion Regimen
• check for heavy metal and/or environmental toxins
• consider a deficiency of minerals and micronutrients

Monday-Friday: for weeks to months

• OKOUBASAN® 2X drops 1x 2-10 and
USNEABASAN® drops 1x 2-10 in daily alternation
(begin with a low dosage)

Saturday-Sunday:
• LUFFASAN® 4X tablets 1x ½ -2 daily or
LUFFASAN® 4X drops 1-3x 5-10 daily

44
 SANUM Excretion Regimen II
Additionally:
• MAPURIT® capsules 1x 1-2 daily
• morning: SELENOKEHL® 4X drops 1x 10 or/and
SELEN-BIOFRID capsules 1x 1-2 daily
• evening: ZINKOKEHL® 3X drops 1x 10 or/and
ZINK + BIOTIN (Biofrid) capsules 1x 1-2 daily
• diet according to Dr. Werthmann
• cold pressed oils with unsaturated fatty acids
(olive, linseed, pumpkinseed oil, fish oil)
• healing earth
• unfiltered apple vinegar

45
 Summary

Milieu
Haptens SANUVIS®
SANUKEHL® Myc CITROKEHL®
SANUKEHL® Pseu FORMASAN®

Allergy
ISOPATHY
Immune Modulators
MUCOKEHL®
RECARCIN®
NIGERSAN®
UTILIN® and UTILIN S
FORTAKEHL®
LATENSIN®
NOTAKEHL®
REBAS®

46
Thank you very much
for listening!

47