Pnas 1718418115 Sapp

Mapping Cortical Brain Asymmetry in 17,141 Healthy Individuals Worldwide via the ENIGMA Consortium
Abbreviated title: Mapping Cortical Brain Asymmetry
Authors from the ENIGMA Laterality Working Group
Xiang-Zhen Kong (1), Samuel R. Mathias (2), Tulio Guadalupe (1), Christoph Abé (3), Ingrid Agartz (4,5,6), Theophilus N. Akudjedu (7),
Andre Aleman (8), Saud Alhusaini (9,10), Nicholas B. Allen (11,12), David Ames (13,14), Ole A. Andreassen (15), Alejandro Arias
Vasquez (16,17,18,19), Nicola J. Armstrong (20), Felipe Bergo (21), Mark E. Bastin (22,23), Albert Batalla (24), Jochen Bauer (25),
Bernhard T Baune (26), Ramona Baur-Streubel (27), Joseph Biederman (28,29), Sara K. Blaine (2), Premika Boedhoe (30,31,32), Erlend
Bøen (6), Anushree Bose (33), Janita Bralten (16,34), Daniel Brandeis (35,36,37,38), Silvia Brem (35,36), Henry Brodaty (39,40), Dilara
Yüksel (41), Samantha J. Brooks (42), Jan Buitelaar (34,43,44), Christian Bürger (45), Robin Bülow (46), Vince Calhoun (47,48), Anna
Calvo (49,50), Erick Jorge Canales-Rodríguez (51,52,53,54), Jose M. Canive (55), Dara M. Cannon (7), Elisabeth C. Caparelli (56),
Francisco X. Castellanos (57,58), Gianpiero L. Cavalleri (9), Fernando Cendes (21), Tiffany Moukbel Chaim-Avancini (59,60), Kaylita
Chantiluke (61), Qun-lin Chen (62,63), Xiayu Chen (64), Yuqi Cheng (65), Anastasia Christakou (66,67), Vincent P. Clark (47,68), David
Coghill (69,70), Colm G. Connolly (71,72), Annette Conzelmann (73), Aldo Córdova-Palomera (74), Janna Cousijn (75), Tim Crow (76),
Ana Cubillo (61), Anders Dale (77,78), Udo Dannlowski (45), Sara Ambrosino de Bruttopilo (79), Patrick de Zeeuw (79), Ian J. Deary (80),
Norman Delanty (9), Damion V. Demeter (81), Adriana Di Martino (57), Erin W Dickie (82), Bruno Dietsche (41), N. Trung Doan (74),
Colin P. Doherty (83), Alysa Doyle (84,85), Sarah Durston (79), Eric Earl (81), Stefan Ehrlich (86), Carl Johan Ekman (3), Torbjørn
Elvsåshagen (87,88), Jeffery N. Epstein (89,90), Damien A. Fair (91,92,93), Stephen V. Faraone (94,95), Guillén Fernández (96,18), Geraldo
Busatto Filho (59,60), Katharina Förster (45,97), Jean-Paul Fouche (98), John J. Foxe (99), Thomas Frodl (100), Paola Fuentes-Claramonte
(51,52), Janice Fullerton (101,102), Hugh Garavan (103), Danielle do Santos Garcia (104), Ian H. Gotlib (105), Anna E. Goudriaan
(106,107), Hans Jörgen Grabe (108,109), Nynke A. Groenewold (110), Dominik Grotegerd (45), Oliver Gruber (111), Tiril Gurholt (4), Jan
Haavik (94,112), Tim Hahn (45), Narelle K. Hansell (113), Mathew A. Harris (22,114), Catharina A. Hartman (115), Maria del Carmen
Valdés Hernández (22,23), Dirk Heslenfeld (116,117), Robert Hester (118), Derrek Paul Hibar (119), Beng-Choon Ho (120), Tiffany C. Ho
(72,121), Pieter J. Hoekstra (122), Ruth J. van Holst (123,124), Martine Hoogman (16,34), Marie F. Høvik (125,125), Fleur M. Howells (42),
Kenneth Hugdahl (112,126), Chaim Huyser (127,128), Martin Ingvar (3), Lourdes Irwin (129), Akari Ishikawa (104), Anthony James (130),
Neda Jahanshad (119), Terry L. Jernigan (131,132), Erik G Jönsson (133,5), Claas Kähler (45), Vasily Kaleda (134), Clare Kelly
(135,136,137,138), Michael Kerich (139), Matcheri S. Keshavan (140), Sabin Khadka (141), Tilo Kircher (41), Gregor Kohls (142), Kerstin
Konrad (142), Ozlem Korucuoglu (143), Bernd Krämer (111), Axel Krug (41), Jun Soo Kwon (144,145), Nanda Lambregts-Rommelse
(17,43), Mikael Landén (146,5), Luisa Lázaro (147,148,149,150), Irina Lebedeva (134), Rhoshel Lenroot (151,152,153), Klaus-Peter Lesch
(154,155,156), Qinqin Li (157), Kelvin O. Lim (158), Jia Liu (157), Christine Lochner (159), Edythe D. London (160), Vera Lonning (4),
Valentina Lorenzetti (161), Michelle Luciano (80), Maartje Luijten (162), Astri J. Lundervold (94,126), Scott Mackey (103), Frank P.
MacMaster (163,164,165,166,167), Sophie Maingault (168), Charles B. Malpas (169), Ulrik F. Malt (170,171), David Mataix-Cols (5),
Rocio Martin-Santos (172), Andrew R. Mayer (47), Hazel McCarthy (173), Philip B. Mitchell (151,174,175), Bryon A. Mueller (158),
Susana Muñoz Maniega (22,23), Bernard Mazoyer (176), Colm McDonald (7), Quinn McLellan (177,178), Katie L. McMahon (179),
Genevieve McPhilemy (7), Reza Momenan (139), Angelica M. Morales (160), Janardhanan C. Narayanaswamy (33), José Carlos Vasques
Moreira (104), Stener Nerland (6), Liam Nestor (180), Erik Newman (132), Joel T. Nigg (129), Jan Egil Nordvik (181), Stephanie Novotny
(141), Eileen Oberwelland Weiss (142), Ruth L. O’Gorman (182,37), Jaap Oosterlaan (183,184,185), Bob Oranje (79), Catherine Orr (103),
Bronwyn Overs (101), Paul Pauli (27), Martin Paulus (186,187), Kerstin Jessica Plessen (94,188), Georg G. von Polier (142), Edith Pomarol-
Clotet (51,52), Maria J. Portella (189), Jiang Qiu (62,63), Joaquim Radua (51,52,190,191), Josep Antoni Ramos-Quiroga (192,193), Y.C.
Janardhan Reddy (33), Andreas Reif (194), Gloria Roberts (151,174), Pedro Rosa (59,60), Katya Rubia (61), Matthew D. Sacchet (195),
Perminder S. Sachdev (39,196), Raymond Salvador (51,52), Lianne Schmaal (11,197,30), Martin Schulte-Rüther (142,198), Lizanne
Schweren (122), Larry Seidman (28,140), Jochen Seitz (199), Mauricio Henriques Serpa (59,60), Philip Shaw (200,201), Elena Shumskaya
(16,34), Timothy J. Silk (169,202,203), Alan N. Simmons (204,205), Egle Simulionyte (111), Rajita Sinha (2), Zsuzsika Sjoerds (206,207),
Runar Elle Smelror (4), Joan Carlos Soliva (192), Nadia Solowij (208), Fabio Luisde Souza-Duran (59,60), Scott R. Sponheim (209), Dan J.
Stein (42,210), Elliot A. Stein (56), Michael Stevens (211,212,213), Lachlan T. Strike (113), Gustavo Sudre (200), Jing Sui (47,214), Leanne
Tamm (215), Hendrik S. Temmingh (42), Robert J. Thoma (216,217), Alexander Tomyshev (134), Giulia Tronchin (7), Jessica Turner (218),
Anne Uhlmann (159,42,103), Theo G.M. van Erp (219), Odile A. van den Heuvel (30,31,32), Dennis van der Meer (220), Liza van Eijk
(221,113), Alasdair Vance (222), Ilya M. Veer (223), Dick J. Veltman (30), Ganesan Venkatasubramanian (33), Oscar Vilarroya (192,224),
Yolanda Vives-Gilabert (225), Aristotle N Voineskos (82,226), Henry Völzke (227,228,229), Daniella Vuletic (42), Susanne Walitza
(35,36,37), Henrik Walter (223), Esther Walton (230), Joanna M. Wardlaw (231,232,233), Wei Wen (39), Lars T. Westlye (234,235),
Christopher D. Whelan (9), Tonya White (236,237), Reinout W. Wiers (75), Margaret J. Wright (113,179), Katharina Wittfeld (109,108),
Tony T. Yang (72), Clarissa L. Yasuda (104), Yuliya Yoncheva (57), Murat Yücel (238), Je-Yeon Yun (239,240), Marcus Vinicius Zanetti
(59,60), Zonglei Zhen (64), Xing-xing Zhu (62,63), Georg C. Ziegler (154), Kathrin Zierhut (27), Greig I. de Zubicaray (241), Marcel Zwiers
(34), Karolinska Schizophrenia Project (KaSP) (242), David C. Glahn (2,243), Barbara Franke (244,245), Fabrice Crivello (176), Nathalie
Tzourio-Mazoyer (176), Simon E. Fisher (1,246), Paul M. Thompson (119), Clyde Francks (1,246)
1. Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.
2. Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
3. Department of Clinical Neuroscience, Osher Centre, Karolinska Institutet, Stockholm, Sweden.
4. Norwegian Centre for Mental Disorders Research (NORMENT), K. G. Jebsen Centre for Psychosis Research, Institute of Clinical
Medicine, University of Oslo, Oslo, Norway.
5. Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden.
www.pnas.org/cgi/doi/10.1073/pnas.1718418115
6. Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.
7. The Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Lab, NCBES Galway Neuroscience Centre,
College of Medicine, Nursing, and Health Sciences, National University of Ireland Galway, H91 TK33 Galway Ireland, Republic of Ireland.
8. BCN Neuroimaging Center, Department of Neuroscience, University Medical Center Groningen, University of Groningen, The
Netherlands.
9. Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.
10. Neurology and Neurosurgery Department, Montreal Neurological Hospital and Institute, McGill University, Montreal, Canada.
11. Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Australia.
12. Department of Psychology, University of Oregon, Eugene OR, USA.
13. National Ageing Research Institute, Melbourne, Australia.
14. Academic Unit for Psychiatry of Old Age, University of Melbourne, Melbourne, Australia.
15. Norwegian Centre for Mental Disorders Research (NORMENT), KG Jebsen Centre for Psychosis Research, Division of Mental Health
and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
16. Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
17. Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
18. Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands.
19. Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
20. Mathematics and Statistics, Murdoch University, Perth, Australia.
21. Laboratory of Neuroimaging, Department of Neurology, University of Campinas.
22. Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
23. Brain Research Imaging Centre, University of Edinburgh, Edinburgh, UK.
24. Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The
Netherlands.
25. Department of Clinical Radiology, School of Medicine, University of Münster, Germany.
26. Discipline of Psychiatry, University of Adelaide, Australia.
27. Department of Psychology, University of Würzburg, Germany, Würzburg, Germany.
28. Department of Psychiatry, Harvard Medical School, Boston, Mass, USA.
29. Clinical and Research Programs in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Boston, MA,
USA.
30. Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands.
31. Department of Anatomy & Neurosciences, VU University Medical Center, Amsterdam, The Netherlands.
32. Amsterdam Neuroscience, Amsterdam, The Netherlands.
33. Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, India.
34. Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands.
35. Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich,
Zurich, Switzerland.
36. Neuroscience Center Zurich, University of Zurich and ETH Zurich, Switzerland.
37. Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.
38. Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty
Mannheim/Heidelberg University, J5, 68159 Mannheim, Germany.
39. Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Australia.
40. Dementia Collaborative Research Centre ØC Assessment and Better Care, University of New South Wales, Sydney, Australia.
41. Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Germany.
42. Department of Psychiatry and Mental Health, University of Cape Town, South Africa.
43. Karakter Child and Adolescent Psychiatry, Nijmegen, The Netherlands.
44. Department of Cognitive Neuroscience, Radboud university, Nijmegen, The Netherlands.
45. Department of Psychiatry, University of Münster, Germany.
46. Department of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.
47. The Mind Research Network, Albuquerque, NM, USA.
48. Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque, NM 87131, United States.
49. Medical Image Core Facility, August Pi I Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.
50. CIBERBBN.
51. FIDMAG Germanes Hospitalaries Research Foundation, Barcelona, Spain.
52. CIBERSAM, Centro de Investigación Biomédica en Red de Salud Mental, Spain.
53. Department of Radiology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
54. Signal Processing Laboratory 5 (LTS5), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
55. Departments of Psychiatry and Neurosciences, University of New Mexico.
56. Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA.
57. Department of Child and Adolescent Psychiatry, Hassenfeld Children's Hospital at NYU Langone, New York, USA.
58. Division of Clinical Research, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA.
59. Department of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
60. Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), University of São Paulo, São Paulo, Brazil.
61. King's College London, Institute of Psychiatry, Psychology and Neuroscience, Department of Child and Adolescent Psychiatry, London,
UK.
62. School of Psychology, Southwest University, Chongqing, China.
63. Key Laboratory of Cognition and Personality, Ministry of Education, Chongqing, China.
64. State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Faculty of Psychology,
Beijing Normal University, Beijing, China.
65. Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China.
66. Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King's College London, London WC2R 2LS, UK.
67. School of Psychology and Clinical Language Sciences, University of Reading, Reading RG6 6AL, UK.
68. Department of Psychology, University of New Mexico, Albuquerque, NM 87131, United States.
69. Departments of Paediatrics and Psychiatry, University of Melbourne. Victoria, Australia.
70. Division of Neuroscience, Ninewells Hospital and Medical School, University of Dundee.
71. Department of Biomedical Sciences, Florida State University, Tallahassee, FL 32306, USA.
72. Department of Psychiatry, Division of Child and Adolescent Psychiatry, and Weill Institute for Neurosciences, University of California,
San Francisco, 401 Parnassus Avenue, San Francisco, CA, USA.
73. Department of Child and Adolescent Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.
74. Norwegian Centre for Mental Disorder Research (NORMENT), K.G. Jebsen Centre for Psychosis Research, Division of Mental Health
and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
75. Department of Developmental Psychology, University of Amsterdam, Amsterdam, the Netherlands.
76. SANE POWIC, University Department of Psychiatry, Warneford Hospital, Oxford, UK.
77. Departments of Neurosciences and Radiology, University of California, San Diego, San Diego, CA,USA.
78. UCSD Center for Translational Imaging and Precision Medicine, San Diego, CA, USA.
79. NICHE-lab, Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.
80. Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh, UK.
81. Department of Behavioral Neuroscience at Oregon Health & Science University, Portland, OR, USA.
82. Kimel Family Translational Imaging-Genetics Research Laboratory, Campbell Family Mental Health Research Institute, Center for
Addiction and Mental Health, Toronto, Canada.
83. Neurology Department, St. James's Hospital, Dublin, Ireland.
84. Department of Psychiatry & Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA,USA.
85. Stanley Center for Psychiatric Research at the Broad Institute, Cambridge, MA, USA.
86. Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden,
Dresden, Germany.
87. Norwegian Centre for Mental Disorder Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
88. Department of Neurology, Oslo University Hospital, Oslo, Norway.
89. University of Cincinnati College of Medicine, Cincinnati, OH, USA.
90. Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
91. Department of Behavioral Neuroscience, Oregon Health & Science University, USA.
92. Department of Psychiatry, Oregon Health & Science University, USA.
93. Advanced Imaging Research Center, Oregon Health & Science University, USA.
94. K.G. Jebsen Centre for Neuropsychiatric Disorders, Department of Biomedicine, University of Bergen, Bergen, Norway.
95. Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY, USA.
96. Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
97. Institute of Psychiatric Phenomics and Genomics (IPPG), Ludwig-Maximilians-University, Munich, Germany.
98. Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
99. The Ernest J. Del Monte Institute for Neuroscience, Department of Neuroscience, University of Rochester School of Medicine and
Dentistry.
100. Department of Psychiatry and Psychotherapy, University Hospital, Otto-von-Guericke-University, Magdeburg, Germany.
101. Neuroscience Research Australia, Sydney, NSW, Australia.
102. School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia.
103. Department of Psychiatry, University of Vermont, Burlington, VT, USA.
104. Laboratory of Neuroimaging, Department of Neurology, University of Campinas, Campinas, Brazil.
105. Department of Psychology, Stanford University, USA.
106. Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
107. Arkin Mental Health & Amsterdam Institute for Addiction Research, Academic Medical Center, University of Amsterdam.
108. Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Germany.
109. German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Germany.
110. Interdisciplinary Center Psychopathology and Emotion Regulation, University Medical Center Groningen, University of Groningen,
The Netherlands.
111. Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg,
Germany.
112. Department of Psychiatry, Haukeland University Hospital, Bergen, Norway.
113. Queensland Brain Institute, University of Queensland, Brisbane, Australia.

114. Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
115. Department of Psychiatry, University Medical Center Groningen, University of Groningen, The Netherlands.
116. Department of Cognitive Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
117. Department of Clinical Neuropsychology, VU University Amsterdam, Amsterdam, The Netherlands.
118. School of Psychological Sciences, University of Melbourne, Melbourne, Australia.
119. Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Marina
del Rey, CA 90292 USA.
120. Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa, USA.
121. Department of Psychology, Stanford University, Stanford, CA, USA.
122. University of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, The Netherlands.
123. Amsterdam Institute for Addiction Research, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
124. Department of Psychiatry, Amsterdam, The Netherlands.
125. Department of Clinical Medicine, University of Bergen, Bergen, Norway.
126. Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway.
127. De Bascule, Academic Center for Child and Adolescent Psychiatry, Amsterdam, the Netherlands.
128. AMC, Department of Child and Adolescent Psychiatry, Amsterdam, the Netherlands.
129. Department of Psychiatry, Oregon Health & Science University, Portland, OR, USA.
130. University Department of Psychiatry, Warneford Hospital, Oxford, UK .
131. Departments of Cognitive Science, Psychiatry, Radiology, University of California, San Diego, CA, USA.
132. Center for Human Development, University of California, San Diego, CA, USA.
133. Norwegian Centre for Mental Disorders Research (NORMENT), K.G. Jebsen Centre for Psychosis Research, Division of Mental Health
and Addiction, Oslo University Hospital, Oslo, Norway.
134. Mental Health Research Center, Moscow, Russia.
135. Department of Psychiatry, University of Dublin, Trinity College Dublin, Dublin, Ireland.
136. The Child Study Center at NYU Langone Medical Center, New York, USA.
137. School of Psychology, Trinity College, Dublin, Ireland.
138. Trinity College Institute of Neuroscience, Dublin, Ireland.
139. Clinical NeuroImaging Research Core, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Baltimore,
MD, USA.
140. Beth Israel Deaconess Medical Center, Boston, MA, USA.
141. Olin Neuropsychiatry Research Center, Hartford CT, USA.
142. Child Neuropsychology Section, Department of Child and Adolescent Psychiatry, University Hospital Aachen, Aachen, Germany.
143. Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
144. Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.
145. Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Republic of Korea.
146. Institute of Neuroscience and Physiology, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden.
147. Department of Child and Adolescent Psychiatry and Psychology, Hospital Clínic, Barcelona, Spain.
148. August Pi I Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.
149. Department of Medicine, University of Barcelona, Barcelona, Spain.
150. CIBERSAM.
151. School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.
152. Neuroscience Research Australia, Sydney, NSW, Australia .
153. University of New Mexico, Albuquerque, New Mexico.
154. Division of Molecular Psychiatry, Center of Mental Health, University of Würzburg, Würzburg, Germany.
155. Laboratory of Psychiatric Neurobiology, Institute of Molecular Medicine, I.M. Sechenov First Moscow State Medical University,
Moscow, Russia.
156. Department of Translational Neuroscience, School for Mental Health and Neuroscience (MHeNS), Maastricht University, Maastricht,
The Netherlands.
157. Beijing Key Laboratory of Applied Experimental Psychology, National Demonstration Center for Experimental Psychology Education
(Beijing Normal University), Faculty of Psychology, Beijing Normal University, Beijing, China.
158. Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA.
159. SU/UCT MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, South Africa.
160. Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA.
161. Institute of Psychology Health and Society, University of Liverpool, Liverpool, UK.
162. Behavioural Science Institute, Radboud University, Nijmegen, The Netherlands.
163. Departments of Psychiatry and Pediatrics, University of Calgary, Calgary AB, Canada.
164. Child and Adolescent Imaging Research Program, Alberta Children's Hospital, Calgary AB, Canada.
165. Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, University of Calgary, Calgary AB, Canada.
166. Strategic Clinical Network for Addictions and Mental Health, Alberta Health Services, Calgary AB, Canada.
167. Alberta Children's Hospital Research Institute, Calgary AB, Canada.
168. Institut des Maladies Neurodégénératives, UMR 5293. Groupe d’Imagerie Neurofonctionnelle, CEA - CNRS - Université de Bordeaux,
Bordeaux, France.
169. Developmental Imaging, Murdoch Childrens Research Institute, Royal Children‫׳‬s Hospital, Melbourne, Australia.
170. Department of Research and Education, Oslo University Hospital, Oslo, Norway.
171. Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
172. Department of Psychiatry and Psychology, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
173. Department of Psychiatry, Trinity College Dublin, Dublin, Ireland.
174. Black Dog Institute, Prince of Wales Hospital, Randwick, NSW, Australia.
175. Prince of Wales Hospital, Sydney, NSW, Australia.
176. Institut des Maladies Neurodégénératives, UMR 5293. Groupe d’Imagerie Neurofonctionnelle, CEA - CNRS - Université de Bordeaux.
177. Department of Neuroscience, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
178. Alberta Children's Hospital Research Institute, Calgary, AB, Canada.
179. Centre for Advanced Imaging, University of Queensland, Brisbane, Australia.
180. Neuropsychopharmacology Unit, Division of Brian Sciences, Imperial College London, London, UK.
181. Sunnaas Rehabilitation Hospital HT, Nesodden, Norway.
182. Center for MR-Research, University Children’s Hospital, Zurich, Switzerland.
183. Emma Children's Hospital Amsterdam Medical Center, Amsterdam, The Netherlands.
184. VU Medical Center, Amsterdam, The Netherlands.
185. Clinical Neuropsychology section, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
186. Laureate Institute for Brain Research, Tulsa, Oklahoma, USA.
187. Department of Psychiatry, University of California San Diego, La Jolla, California, USA.
188. Child and Adolescent Mental Health Center, Capital Region, Denmark.
189. Biomedical Research Institute Sant Pau, Hospital de la Santa Creu i Sant Pau, Centro de Investigación Biomédica en Red de Salut
Mental (CIBERSAM), Barcelona, Catalonia, Spain.
190. Centre for Psychiatric Research and Education, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
191. Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, UK.
192. Department of Psychiatry and Legal Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
193. Department of Psychiatry, Hospital Universitari Vall d’Hebron, CIBERSAM, Barcelona, Spain.
194. Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
195. Department of Psychiatry and Behavioral Sciences, Stanford University, USA.
196. Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, Australia.
197. Centre for Youth Mental Health, The University of Melbourne, Melbourne, Australia.
198. Translational Brain Research, Department of Child and Adolescent Psychiatry, University Hospital Aachen, Aachen, Germany.
199. Department of Child and Adolescent Psychiatry, University Hospital Aachen, Aachen, Germany.
200. Neurobehavioral Clinical Research Section, National Human Genome Research Institute, Bethesda, USA.
201. National Institute of Mental Health, Bethesda, MD, USA.
202. Department of Paediatrics, University of Melbourne, Melbourne, Australia.
203. School of Psychology, Deakin University, Melbourne, Australia.
204. Department of Psychiatry, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA, USA.
205. Veterans Affairs San Diego Health Care System, La Jolla, CA, USA.
206. Max Planck Institute for Human Cognitive and Brain Sciences, Department of Neurology, Leipzig, Germany.
207. Leiden University, Institute of Psychology, Cognitive Psychology Unit & Leiden Institute for Brain and Cognition, Leiden, The
Netherlands.
208. School of Psychology and Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, Australia.
209. Minneapolis VA Health Care System & University of Minnesota, Minneapolis, MN, USA.
210. SU/UCT MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Mental Health, University of Cape
Town, South Africa.
211. Clinical Neuroscience and Development Laboratory, Olin Neuropsychiatry Research Center, Hartford CT, USA.
212. Child & Adolescent Research, Hartford Hospital/The Institute of Living, Hartford CT, USA.
213. Department of Psychiatry, Yale University School of Medicine, Hartford CT, USA.
214. National laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China.
215. Department of Pediatrics, Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center,
Cincinnati, OH, USA.
216. Department of Psychiatry and Behavioral Sciences, University of New Mexico, Albuquerque, NM, USA.
217. Department of Psychiatry, University of New Mexico, Albuquerque, NM, USA.
218. Department of Psychology and Neuroscience Institute, Georgia State University, Atlanta GA 30302.
219. Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, USA.
220. K.G. Jebsen Centre for Psychosis Research / Norwegian Centre for Mental Disorder Research (NORMENT), Institute of Clinical
Medicine, University of Oslo, Oslo, Norway.
221. School of Psychology, University of Queensland, Brisbane, Australia.
222. Academic Child Psychiatry Unit, Royal Children’s Hospital, University of Melbourne, Melbourne, Victoria, Australia.
223. Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin
Institute of Health, Department of Psychiatry and Psychotherapy, Campus Mitte, Berlin, Germany.
224. Fundació IMIM, Barcelona, Spain.
225. INNDACYT, Barcelona, Spain.
226. Department of Psychiatry, University of Toronto, Toronto, Canada.
227. Institute for Community Medicine, University Medicine Greifswald, Germany.
228. DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Germany.
229. German Centre for Diabetes Research (DZD), Site Greifswald, Germany.
230. Department of Psychology, Georgia State University, Atlanta GA, USA.
231. Brain Research Imaging Centre, Centre for Clinical Brain Sciences and Dementia Research Institute at the University of Edinburgh,
Edinburgh, UK.
232. Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Edinburgh, UK.
233. Centre for Clinical Brain Sciences, Centre for Cognitive Ageing and Cognitive Epidemiology, and UK Dementia Research Institute at
The University of Edinburgh, Edinburgh, UK.
234. NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute
of Clinical Medicine, University of Oslo, Oslo, Norway.
235. Department of Psychology, University of Oslo, Oslo, Norway.
236. Department of Child and Adolescent Psychiatry, Erasmus University Medical Centre, Rotterdam, Netherlands.
237. Department of Radiology, Erasmus University Medical Centre, Rotterdam, Netherlands.
238. Monash Institute of Cognitive and Clinical Neurosciences and School of Psychological Sciences, Monash University, Melbourne,
Australia.
239. Seoul National University Hospital, Seoul, Republic of Korea.
240. Yeongeon Student Support Center, Seoul National University College of Medicine, Seoul, Republic of Korea.
241. Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
242. Members of Karolinska Schizophrenia Project (KaSP) are listed in SI.
243. Olin Neuropsychiatric Research Center, Hartford, CT, USA.
244. Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen,
The Netherlands.
245. Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The
Netherlands.
246. Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, The Netherlands.
Collaborators from the Karolinska Schizophrenia Project (KaSP) consortium
Lars Farde (1), Lena Flyckt (1), Göran Engberg (2), Sophie Erhardt (2), Helena Fatouros-Bergman (1), Simon Cervenka (1), Lilly Schwieler
(2), Fredrik Piehl (3), Ingrid Agartz (1, 4, 5), Karin Collste (1), Pauliina Victorsson (1), Anna Malmqvist (2), Mikael Hedberg (2), Funda
Orhan (2)
1. Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm County Council, Stockholm,
Sweden
2. Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
3. Neuroimmunology Unit, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
4. NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, University of Oslo, Oslo, Norway
5. Department of Psychiatry Research, Diakonhjemmet Hospital, Oslo, Norway

Supporting Information
SI Materials and Methods
Datasets. The primary datasets used in this study for large-scale meta-analysis were from members of
the Lateralization Working Group within the ENIGMA Consortium (1). There were 99 independent
samples, including 17,141 healthy participants from diverse ethnic backgrounds. Samples were drawn
from the general population or were healthy controls from clinical studies. While we made use of
control data from case-control cohorts of psychiatric diseases, no data from the affected cases in these
datasets were used in the present study. For more details on each sample, see Dataset S1. All local
institutional review boards permitted the use of extracted measures of the completely anonymized
data.
Handedness was known for a subset of the participants. The method of assessment varied across
samples (see Further Information about Each Dataset below). An ambidextrous category was not
included, resulting in 827 left-handed and 11,237 right-handed participants in total.
Two additional datasets were used to estimate heritability of asymmetry measures, i.e. the GOBS
dataset and the HCP dataset. GOBS is a family study comprising 1,443 individuals with MRI data
(836 females), aged between 18 and 85 years at the time of scanning (2). All GOBS subjects are
Mexican Americans and belong to pedigrees of varying sizes (the largest pedigree has 143 members).
The HCP is a large-scale project comprising 1,113 individuals with MRI data (606 females, age range
22-37 years at the time of scanning) of varying ethnicities (http://humanconnectome.org/). The HCP
contains 143 monozygotic twin pairs and 85 dizygotic twin pairs, as well as unrelated individuals.
Image Acquisition and Processing. Structural T1-weighted MRI scans were acquired and analyzed
locally. Images were acquired at different field strengths (1.5 T and 3 T). All images were analyzed
using the automated and validated pipeline “recon-all” implemented in FreeSurfer (version 5.3 for 91
of 99 samples). Briefly, the processing pipeline consists of 34 stages described in the help document of
“recon-all”, the main stages of which include normalization of brain signal intensity, skull-stripping,
white matter and gray matter segmentation, and delineation of the gray-white interface (inner surface)
and the pial surface (outer surface). Next, the surface is divided into separate cortical regions using an
automated labeling approach, where not only location information based on the probabilistic surface-
based atlas, but also local curvature and contextual information (e.g., sulcal and gyral geometry) of
subject-specific surface are taken into consideration. Finally, surface area and mean cortical thickness
was extracted for each of the 68 regions (34 per hemisphere) in the parcellation scheme (i.e., Desikan-
Killiany atlas) (3), as well as each hemisphere. Calculations were made in each subject’s native space.
In the present study, we chose this parcellation approach mainly because it is well-established in
the surface space, and has been widely used in brain structure studies. For example, this pipeline has
also been shown to have an overall high level of validity when comparing with manual labeling
regions, and high test-retest reliability (3). Furthermore, no differences were found in the labeling
accuracy between the two hemispheres (3). In addition, as this surface-based parcellation is integrated
in the automated reconstruction pipeline in FreeSurfer, it is feasible to apply for large collaborative
projects, and this also has the advantage of providing a comparable normative resource for future
studies (e.g., altered asymmetry in disorders). For more details on the image processing, please refer to
(3).
For each dataset, segmentations of 68 (34 per hemisphere) cortical regions were statistically
evaluated and in some cases visually inspected for outliers. Besides regional measures of cortical
thickness and surface area, two hemisphere-level measures (average cortical thickness and total
surface area), as well as the intracranial volume (ICV) were obtained for each participant. Quality
control and data analysis were performed following standardized ENIGMA protocols (see
http://enigma.ini.usc.edu/protocols/imaging-protocols/). In addition, following Guadalupe et al.
(2016), we performed several checks to assess potential errors in the left-right orientation of the data.
Further details for the datasets (Further Information about Each Dataset) and orientation checking
(Left-right Orientation Checks) can be found below.
Within-dataset Analyses. For each dataset, descriptive and statistical analyses of the asymmetries in
both cortical thickness and surface area were performed at each participating site using a single script
in the R language, based on unified table-formatted data. For each global hemispheric or regional
measure, an asymmetry index (AI) was defined as (L-R)/((L+R)/2), where L and R are the
corresponding thickness or area measures on the left and right hemisphere, respectively. Thus, positive
and negative AI values indicate leftward and rightward asymmetry, respectively. In addition, it is
important to note that in the definition of the AI, the difference (i.e., L-R) was normalized with the
bilateral area or thickness as denominator (i.e., L+R), such that the measure does not necessarily scale
with the overall magnitude of L and R. To exclude possible outliers in measures of cortical thickness,
surface area, or AIs, we followed Guadalupe et al. (2016) and used an adaptive threshold (SDthre)
depending on each dataset’s sample size: N < 150, SDthr = 2.5; 150 ≤ N ≤ 1000, SDthr = 3; N > 1000,
SDthr = 3.5. The adaptive threshold method was applied because outliers at similar levels can have
different influences in datasets with different sample sizes. For example, while outliers at 3SD might
have strong influence in small samples, the influence of data points at 3SD in much larger datasets
would be very limited. Using a single threshold suitable for small samples could exclude too many
subjects for datasets with large sample sizes, which is not necessary, but instead reduces the statistical
power. The median number of individuals that was excluded in each dataset are given in SI Data sheet
S1. The number varied within datasets depending on the specific regional measure.
Statistical tests were run for each hemisphere-level or regional measure separately. Paired t-tests
were used to assess inter-hemispheric differences. Cohen’s d was calculated based on each paired t-
test result to estimate the effect size of population-level asymmetry. All differences between sexes (-
1=females, 1=males) were assessed with linear regression models adjusted for age, age2, and ICV.
Cohen’s d was calculated to estimate the effect size for each comparison. Furthermore, we examined
the age effects on the AIs in cortical thickness and surface area, adjusting for sex and ICV. Similarly,
we examined associations between ICV and the AIs in cortical thickness and surface area, adjusting
for age, age2, and sex. In addition, if handedness information was available, AI differences between
handedness groups (-1=left; 1=right) were assessed with linear regression models adjusted for all the
other covariates. For each analysis above, additional covariates of scanners were included when more
than one scanner was used at one site.
We additionally used the primary data of the BIG dataset (SI Data sheet S1) to compare models
with and without including the age2 term, and found the identical sets of significant effects for the
other factors, that is age, sex, ICV all showed precisely the same patterns of significant effects across
cortical regions. This showed that the models were not confounded by collinearity between age and
age2.
Meta-analyses. All regression models and effect size estimates were fitted at each participating site
separately. We then combined the output statistics from each dataset using inverse variance-weighted
random-effect meta-analyses (4) with the R package metafor, version 1.9-9. This method tests one
overall effect, while weighting each dataset’s contribution by the inverse of its corresponding
sampling variance. Thus, unlike fixed-effect meta-analysis, this method takes into account variability
across different studies. In addition, test statistics in the meta-analyses were computed based on a
standard normal distribution (test="z" by default).
A Cohen’s d effect size estimate of population-level asymmetry (hemispheric difference) was
obtained using a random-effect meta-analysis model for each region and each cortical measure
(cortical thickness and surface area). Note that including results based on too few participants may
reduce reliability, and therefore we only included datasets with a sample size larger than 15. In the
meta-analysis, heterogeneity of each effect was assessed via the I2 value, which describes the
percentage of total variation across studies that is due to heterogeneity rather than chance. I2 values of
25%, 50%, and 75% indicate a low, moderate, and high heterogeneity, respectively.
Similarly, Cohen’s d estimates of sex and handedness effects on asymmetry were obtained by
meta-analysis for each cortical region. Again we only included samples with at least 15 participants
per group. In addition, we confirmed that variances in the AIs of each region were similar between
males and females, and between right- and left-handers, using two individual datasets (BIG and
BIL&GIN; we applied the F-test comparing the standard deviations between sex and handedness
groups, and found no significant differences for any asymmetry measures, BIG: F[df1, df2] =
0.92~1.14, ps > 0.10, df1 = 1193~1352, df2 = 729~971; BIL&GIN: F[df1, df2] = 0.83~1.23, ps > 0.10,
df1 = 226~231, df2 = 207~220); and similarly no handedness differences were found (BIG: F[df1, df2]
= 0.87~1.17, ps > 0.10, df1 = 1657~1992, df2 = 91~102; BILGIL: F[df1, df2] = 0.73~1.20, ps > 0.10,
df1 = 239~247, df2 = 196~204).

For meta-analyses of the correlations of asymmetries with age or ICV, predictors were treated as
continuous variables, so that effect sizes were expressed as partial-correlation r. For meta-analyses of
age effects, we only included samples with a minimum 5-year range in the initial analysis, and in a
subsequent analysis we further restricted to samples with age ranges larger than 20 years, to better
capture the age effects in our data.
In this study, we report uncorrected p values with a significance threshold determined by
Bonferroni correction for multiple comparisons within each separate meta-analysis (i.e. correction
separately for analysis of 34 regional surface area asymmetries and 34 regional thickness asymmetries,
p = 0.05/34 = 0.00147). No correction was done for global hemispheric measures of asymmetry.
Moderator analyses with meta-regression. Meta-regressions were performed to evaluate the
potential moderating effects on meta-analysis effect sizes. We tested whether moderating factors,
including median age, median ICV, sex ratio, handedness ratio, and MRI scanner field strength (3T, N
= 63 datasets versus 1.5T, N = 28 datasets), influenced the effect size estimates across datasets in the
meta-analyses. Each moderator variable was separately included as a fixed effect predictor in the
meta-regression model. All statistical analyses were conducted using the R software package metafor,
and Bonferroni correction was applied for multiple comparisons (p < 0.00147; see above).
Heritability estimation. Furthermore, we estimated the heritability of asymmetries in cortical
thickness and surface area, firstly using the GOBS dataset (N = 1,443; see ‘Datasets’ above). For more
details about this cohort, see McKay et al. (2014). Specifically, we estimated the narrow-sense
heritability (i.e., the proportion of overall variance explained by additive genetic effects) of each AI
using variance-components analysis (5). Briefly, each AI was entered as a dependent variable into a
linear mixed-effects model, which included fixed effects of age, sex, and ICV, and a random effect of
genetic similarity, whose covariance structure was determined by the pedigrees. We refer to these as
univariate polygenic models. Second, we estimated the genetic correlations between left and right
thickness/area measures by extending the univariate polygenic models to incorporate two traits at
once; these bivariate polygenic models simultaneously estimate the heritability of left and right paired
measures, along with their genetic correlation (which indicates the extent to which their variation is
influenced by the same genetic factors).
Finally, we performed similar heritability analyses in the HCP cohort (N = 1,113; see ‘Datasets’
above) to replicate findings observed with the GOBS dataset. HCP is a large-scale project which
includes monozygotic (MZ) and dizygotic (DZ) twin pairs, as well as unrelated individuals. Precisely
the same analyses were conducted in this second cohort, except for the covariance structure calculation
across individuals. Specifically, in the twin study, MZ twins are coded as 1 as they share 100% of their
DNA sequence, DZ twins and siblings are coded as 0.5 as they share on average 50%, and unrelated
individuals are coded as zero as they share on average zero.

SI Results
Moderator analyses using meta-regression. As shown in Fig. 2, 3 and SI Data sheet S2, we
observed moderate to substantial heterogeneity in the asymmetry distributions across datasets (I2
ranges from 36% to 98%).
To further address the heterogeneity across the samples included in the meta-analyses, we
investigated several moderating variables, including sex ratio, median age, handedness ratio, and
median ICV. Moderator analyses revealed an influence of the median age of samples on the global
hemispheric difference in surface area (Z = 2.09, p = 0.036), suggesting a reduced rightward
asymmetry with increasing age. No other potential moderators showed significant effects on global
cortical thickness or surface area asymmetry (p > 0.10). Moderator analyses for each specific region
suggested an influence of the median age of samples on the asymmetry of the surface area of the
paracentral gyrus (Z = -4.35, p = 1.38e-5), and an influence of median ICV on the asymmetry of the
surface area in the insula (Z = -3.18, p = 0.0014). Given that both the paracentral gyrus and insula
showed significant rightward asymmetry in surface area, these findings indicate a decreasing
rightward asymmetry with increasing age and with ICV, respectively. In addition, we found a
significant effect of scanner field strength on the surface area asymmetry in the insula (Z = 4.12, p =
3.82e-5). However, this could be largely reduced by including the other moderating variables (i.e., sex
ratio, median age, handedness ratio, and median ICV) in the analysis (Z = 2.35, p = 0.019). Similarly,
we additionally ran separate meta-analyses for studies with 1.5T and 3T scanners in order to gauge
whether magnet field strength was an important factor affecting asymmetry measures, but we found
similar results at 1.5T and 3T. For example, the population-level asymmetries in cortical thickness
across the 34 regions from the two analyses showed high correlations (r = 0.88, p = 7.53e-12).
Relationship between asymmetry of cortical thickness and surface area. Previous studies have
suggested that thickness and surface area are evolutionarily, genetically, and developmentally distinct
(6, 7). We confirmed a lack of correlation across regions between the asymmetries of thickness and
surface areas, which further supports their independent natures. Specifically, effect sizes of cortical
thickness and surface area were found to be independent, as illustrated by the absence of a significant
correlation between thickness and surface area asymmetries across all cortical regions (r = -0.14, p =
0.416).
Moreover, with data on participants’ sex, age, handedness, and ICV, we found no overall
correlations between the effects of these factors across regions, on either cortical thickness or surface
area. Specifically, we did not observe a significant correlation across regions of the sex effects on the
asymmetries of cortical thickness and surface area (r = 0.14, p = 0.434). Similarly, no significant
correlation was found between the age effects across regions on cortical thickness asymmetry and
surface area asymmetry (ps > 0.05 for both age-range thresholds of 5 and 20 years). Similar findings
were found between the handedness effects across regions for cortical thickness asymmetry and
surface area asymmetry (r = -0.15, p = 0.403), and between the effects of ICV (r = -0.14, p = 0.417).
These findings further elaborated the largely independent nature of regional area versus thickness
variability.
References
1. Thompson PM, et al. (2014) The ENIGMA Consortium: large-scale collaborative analyses of
neuroimaging and genetic data. Brain Imaging Behav 8(2):153-182.
2. McKay DR, et al. (2014) Influence of age, sex and genetic factors on the human brain. Brain
Imaging Behav 8(2):143-152.
3. Desikan RS, et al. (2006) An automated labeling system for subdividing the human cerebral
cortex on MRI scans into gyral based regions of interest. Neuroimage 31(3):968-980.
4. Borenstein M, Hedges LV, Higgins JP, & Rothstein HR (2010) A basic introduction to fixed-
effect and random-effects models for meta-analysis. Research synthesis methods 1(2):97-
111.
5. Almasy L & Blangero J (1998) Multipoint quantitative-trait linkage analysis in general
pedigrees. Am J Hum Genet 62(5):1198-1211.
6. Panizzon MS, et al. (2009) Distinct genetic influences on cortical surface area and cortical
thickness. Cereb Cortex 19(11):2728-2735.
7. Raznahan A, et al. (2011) How Does Your Cortex Grow? Journal of Neuroscience 31(19):7174-
7177.
8. Luders E, et al. (2006) Hemispheric asymmetries in cortical thickness. Cereb Cortex
16(8):1232-1238.
9. Zhou D, Lebel C, Evans A, & Beaulieu C (2013) Cortical thickness asymmetry from childhood
to older adulthood. Neuroimage 83:66-74.
10. Plessen KJ, Hugdahl K, Bansal R, Hao X, & Peterson BS (2014) Sex, age, and cognitive
correlates of asymmetries in thickness of the cortical mantle across the life span. J Neurosci
34(18):6294-6302.
11. Koelkebeck K, et al. (2014) The contribution of cortical thickness and surface area to gray
matter asymmetries in the healthy human brain. Hum Brain Mapp 35(12):6011-6022.
12. Chiarello C, Vazquez D, Felton A, & McDowell A (2016) Structural asymmetry of the human
cerebral cortex: Regional and between-subject variability of surface area, cortical thickness,
and local gyrification. Neuropsychologia 93(Pt B):365-379.
13. Maingault S, Tzourio-Mazoyer N, Mazoyer B, & Crivello F (2016) Regional correlations
between cortical thickness and surface area asymmetries: A surface-based morphometry
study of 250 adults. Neuropsychologia 93:350-364.
SI Figures
SI Fig. S1. Mixed results of the structural asymmetry in cortical thickness in previous studies.
Details for each study please refer to References above (8-13).
SI Datasets
SI Data sheet S1. Brief summary of each dataset used in the meta-analysis.
SI Data sheet S2. Meta-analysis of population-level asymmetry.

SI Data sheet S3. Meta-analysis of sex effects on cortical asymmetries.
SI Data sheet S4. Meta-analysis of age effects on cortical asymmetries.
SI Data sheet S5. Meta-analysis of group differences by handedness on cortical asymmetries.
SI Data sheet S6. Meta-analysis of ICV effects on cortical asymmetry.
SI Data sheet S7. Heritability of cerebral cortical anatomical asymmetries.

Left-right Orientation Checks
To assure the correct left/right orientation of the processed images is of special importance for brain
asymmetry studies. In the present study, we followed Guadalupe et al. (2016) and did a number of checks
to assess potential errors in the left-right orientation of the data.
First, unlike the other axes (anterior-posterior and superior-inferior), it is hard to detect potential
orientation flips on the left-right axis from visual features. Actually, this is an old issue in previous
imaging processing, and such problems are actually much more unlikely since the adoption of the NIFTI
format for imaging data (http://nifti.nimh.nih.gov/).
Second, several strategies have been used to check the orientation information in the conversion
from DICOM to NIFTI. The BIL&GIN, NESDA, MAS and OATS samples have made use of
paramagnetic fiducial markers on a subset of their subjects, thus eliminating orientation ambiguity. In
QTIM and SHIP, subjects with a known unilateral brain abnormality were used to check the correct
orientation of the image after conversion. In BIG, CLiNG, GEB, GBB and HMS, a few examples were
manually checked for potential mismatches between the DICOM and NIFTI header information, i.e., a
correct flip from ‘radiological’ to ‘neurological’ orientation.
Moreover, we checked the consistency between several commonly used DICOM-to-NIFTI
conversion tools, and DICOM images obtained from different scanners (using examples downloaded
from the manufacturer’s websites). The conversion tools included:
mri_convert: (https://surfer.nmr.mgh.harvard.edu/pub/docs/html/mri_convert.help.xml.html)
MRIConvert: (http://lcni.uoregon.edu/downloads/mriconvert)
dcm2nii: (http://www.cabiatl.com/mricro/mricron/dcm2nii.html)
spm_dicom_convert: http://www.fil.ion.ucl.ac.uk/spm/
Given no problem was found, such orientation issue would unlikely be a big contribution to the present
results.
Finally, we found that, although thickness asymmetry showed large heterogeneity across samples,
the heterogeneity of surface area asymmetry is much smaller. Except a few samples, size effect and
direction of surface area asymmetries are consistent between sample and with the expected literature
(i.e. large rightward asymmetry). This consistent asymmetry in surface area suggests that the “opposite”
asymmetry issue in cortical thickness would unlikely be caused by incorrect orientation issues. In
addition, we further identified several samples showing “opposite” asymmetry in both hemispheric
cortical thickness and surface area compared with the population-level direction. Seven groups were
obtained, including MuensterCohort (N = 739), SanPaulo3 (N = 85), NESDA (N = 65), VanHolst (N =
24), 01_Cheng_3T (N = 93), UMCG (N = 23) and Sjoerds (N = 20). After further checking with the
contributors, no problem was found. These results further confirmed correct orientation and the present
results.
Further Information about Each Dataset
We listed the datasets used in the present study, along with a brief introduction for each dataset, and
information for handedness assessment, imaging scanning and data analysis. Note that one dataset
could come from several projects. Thus, we included the further information for the all projects.
DStein
Dataset Name: Addiction_DStein

Project Name: Meth-CT
Dan J. Stein, Anne Uhlmann
1. Brief introduction, funding with ethical standards

The Meth-CT studies investigate structural and functional brain alterations in methamphetamine-
dependent individuals compared to healthy controls, and the neural underpinnings of psychotic
symptoms. Research was supported by the Department of Psychiatry and Mental Health and the
Human Research Ethics Committee, University of Cape Town, and the Medical Research Council,
South Africa.
2. Handedness Assessment Information

Self-report.
A subgroup completed Edinburgh Handedness Inventory.
3. Image Scanning and Data analysis

3T Siemens Allegra scanner; a 3D T1-weighted multiecho MPRAGE sequence was performed;
anatomical imaging acquisition parameters: TR=2530ms; graded TE=1.53, 3.21, 4.89, 6.57ms; flip
angle=7˚; slices=160; voxel size=1x1x1mm3
Freesurfer 5.3 was used.

Quinn
Dataset Name: MacMasterMDD
We could use "MacMasterMDD" as the merged project heading. So that the samples could be
MacMasterMDD_IWK, MacMasterMDD_Remady, MacMasterMDD_MDDEX, and
MacMasterMDD_BMI.
IWK MDD Cohort:

IWK Research Ethics Board approved. Funding from the Halifax Stanley Centre. Research population
of first-episode major depressive youth (11-21 years of age) and healthy controls.
Self-report.

1.5T Siemens Magnetom Vision. A sagittal scout series was acquired to test image quality. 3D fast
low angle shot (FLASH) sequence was used to acquire data from 124 1.5 mm-thick contiguous
coronal slices through the entire brain (echo time = 5ms, repetition time = 25ms, acquisition matrix =
256 x 256 pixels, field of view = 24 cm and flip angle = 40°). Freesurfer 5.3 was used.
MDDEX (24612):

Written consent was obtained from participants or guardians with approval from the Conjoint Health
Research Ethics Board at the University of Calgary. Support for this research in part from the
Cuthbertson and Fischer Chair in Paediatric Mental Health, the Alberta Children’s Hospital
Foundation, Alberta Children’s Hospital Research Institute for Child and Maternal Health, the
Mathison Centre for Mental Health Research & Education, the Hotchkiss Brain Institute, and the
University of Calgary. This pediatric sample (18-24 years of age).
Self-Report.
Scanning was performed on a 3T GE Discovery MR750 at the Alberta Children’s Hospital.

Anatomical imaging acquisition parameters: axial acquisition, repetition time (TR), 2200 milliseconds
(ms); echo time (TE), 3.04 ms; TI, 766, 780; flip angle, 13 degrees; 208 partitions; 256 × 256 matrix;
and field of view, 256. Freesurfer 5.3 was used.
Remady (24656):

Self-Report.

BMI (24796):


Self-Report.

NeuroIMAGE
Project Name: The NeuroIMAGE (International Multicentre ADHD genetics) project

NeuroIMAGE is an integrated DNA-cognition-MRI-phenotype project with the aim to identify
cognitive, neural and genetic underpinnings of ADHD. The project includes research groups at three
sites in the Netherlands: Nijmegen, Amsterdam and Groningen. Between 2004-2006, a cohort of 350
ADHD families (probands with ADHD combined type and one or more siblings) and 150 control
families (control probands with one or more siblings) was gathered as part of the Dutch side of the
International Multisite ADHD Genetics (IMAGE) project. Data collection included detailed
information on ADHD status, and extensive phenotypic, neuropsychological and genetic data. From
2009-2011, this cohort was invited for a follow-up investigation as part of the NeuroIMAGE project,
and the sample was enlarged with 100 new children. ADHD status, phenotypic and
neuropsychological data were again collected, furthermore magnetic resonance imaging (MRI) brain
scans were acquired and additional genome-wide genotyping completed.
This work was supported by NIH Grant R01MH62873 (to Stephen V. Faraone), NWO Large
Investment Grant 1750102007010 and NWO Brain & Cognition an Integrative Approach grant (433-
09-242) (to Jan Buitelaar), and grants from Radboud University Nijmegen Medical Center, University
Medical Center Groningen and Accare, and VU University Amsterdam. The research leading to these
results also received funding from the European Community’s Seventh Framework Programme
(FP7/2007– 2013) under grant agreement numbers 278948 (TACTICS), 602450 (IMAGEMEND) and
n° 602805 (Aggressotype), and from the European Community’s Horizon 2020 Programme
(H2020/2014 – 2020) under grant agreement n° 643051 (MiND). Barbara Franke is supported by a
Vici grant from NWO (grant number 016-130-669). In addition, Jan Buitelaar and Barbara Franke are
supported by a grant for the ENIGMA Consortium (grant number U54 EB020403) from the BD2K
Initiative of a cross-NIH partnership.
The study was approved by the regional ethics committee (CMO Regio Arnhem – Nijmegen;
2008/163; ABR: NL23894.091.08) and the medical ethical committee of the VU University Medical
Center. All participants and their parents (if the participant was younger than 18 years) signed
informed consent; parents signed informed consent for participants under twelve years of age.
N/A

MRI data in NeuroIMAGE were acquired with either a 1.5 Tesla Siemens Sonata or Avanto scanner.
Of each participant, two high-resolution T1-weighted MP-RAGE anatomical scan were obtained (176
sagittal slices, repetition time = 2730 ms, echo time = 2.95 ms, voxel size = 1.0 x 1.0 x 1.0 mm, field
of view = 256 mm). FreeSurfer version 5.3 was used.
Anna
Dataset Name: OCD_Lazaro
Project Name: The Genetics and Brain Imaging of Pediatric OCD (Clínic_Barcelona)

The data are part of two extensive projects titled “Structural, metabolic and functional abnormalities in
children and adolescents with obsessive-compulsive disorder assessed by magnetic resonance
(volumetric, spectroscopic and functional). Changes according the therapeutic response” and
“Analysis of polimorphisms in candidate genes in early onset obsessive-compulsive disorder.
Relationship with cerebral abnormalities and symptom dimensions. These projects were funding by
two grants (Marató-TV3 01/2010 and Marató-TV3 091710).
Handedness was assessed with a Spanish version of The Edinburgh Inventory (Oldfield, 1971).
Oldfield RC. The assessment and analysis of handedness: The Edinburgh Inventory.
Neuropsychologia 1971; 9:97-113.

Mri data were acquired with either a 1.5 Tesla General Electric scaner or 3 Tesla Siemens Tim Trio
scanner. 3D structural T1-weighted FSRGE sequence (0.98x0.98x1.5mm3 voxel sieze) has been used
in 1.5 T and MPRAGE sequence (1x1x1 mm3 voxel size) in 3 T. FreeSurfer version 5.3 was used
03_Huyser
Project Name: Chaim Huyser (OCD_Huyser)

The database is established since 2006 in the department of child and adolescent psychiatry AMC and
de Bascule, academic center child and adolescent psychiatry for the project neuroimaging studies in
pediatric obsessive-compulsive disorder. In these studies a longitudinal approach was used to
investigate the mechanism of change during cognitive behavioral therapy on a neural level for children
and adolescents with a obsessive-compulsive disorder.
Prof. F. Boer, Prof. DJ Veltman, Prof. O. vd Heuvel, Prof E. de Haan, Dr. L. Wolters and Dr. C.
Huyser were the main investigators in these studies.
These studies were approved by the Ethical committee of the Academic Medical Center in Amsterdam
(MEC 06/053#06.17.0749). All patients and controls and their patients gave written consent. The
studies were supported by a grant from the Amsterdam school of neuroscience (ONWA) for scan
costs.
Self report when in doubt confirmation with the Edinburgh Handedness Inventory
MRI data were acquired with a 3 Tesla Philips Interna scanner. The parameters used were matrix
256x256, 182 slices and, voxel size 1 x 1 x 1.2 mm. Images were processed with FreeSurfer version
5.3.
3T_Child_Adolescent_Lateralization
3 Tesla - 14 Subjects (Up to 18 years old)
Project Name: Neuroimaging Studies in Obsessive Compulsive Disorder and Schizophrenia

(NSIOCDS_3T_Child)
Principal Investigators:
Prof. Y.C. Janardhan Reddy
Prof. Ganesan Venkatasubramanian
Dr. Janardhanan C Narayanaswamy

The 3 Tesla structural MRI data from 171 healthy subjects were obtained as part of three funded
projects Government of India grants to the Wellcome-DBT India Alliance grant to Dr.
Venkatasubramanian (500236/Z/11/Z), Prof. Reddy (SR/S0/HS/0016/2011) and Dr. Narayanaswamy
(DST INSPIRE faculty grant -IFA12-LSBM-26) of the Department of Science and Technology; the
Government of India grants to Prof. Reddy No.BT/PR13334/Med/30/259/2009) and Dr.
Narayanaswamy (BT/06/IYBA/2012) of the Department of Biotechnology.
These research studies examined patients with schizophrenia or obsessive-compulsive disorder and the
healthy controls were recruited as comparison subjects.
Self-report confirmed by Edinburgh Handedness Inventory

Structural MRI data details
3T Pediatric - (Philips Achieva): matrix 256X256, 165 slices, voxel size: 1.0 X 1.0 X 1.0 mm;
Y.C. Janardhan Reddy
Ganesan Venkatasubramanian
Janardhanan C Narayanaswamy
TOP3T_GE750
Project Name: TOP3T GE750 and STROKEMRI2 (TOP3T_2)

Participants were recruited from two concurrent projects (STROKEMRI and TOP) using the same
MRI scanner and pulse sequences. For STROKEMRI, participants were recruited from social media
and newspaper ads. Inclusion criteria were: (i) age 18 years or older, (ii) history of neurologic,
psychiatric condition as well as alcohol or substance abuse, (iii) abnormal radiological findings
requiring medical follow-up (e.g. silent stroke, tumor). For TOP, subjects were invited after a stratified
random selection drawn from the Norwegian National Population Registry. All underwent initial
interview where demographic and clinical information was obtained. Exclusion criteria included a
history of head trauma with loss of consciousness of more than 10 minutes duration, moderate to
severe psychiatric or somatic disease, first-degree relatives with mental illnesses (schizophrenia,
bipolar disorder, and major depression disorder), excessive substance abuse during the last 12 months,
or not being able to perform an MRI scan. Blood samples were taken for standard hospital
hematological screening to rule out on-going illnesses and a urine sample was collected to screen for
substance abuse.
The TOP study was supported by the Research Council of Norway (#160181, 190311, 223273,
213837, 249711), the South-East Norway Health Authority (2014114, 2014097, 2017- 112), and the
Kristian Gerhard Jebsen Stiftelsen (SKGJ-MED-008) and the European Community's Seventh
Framework Programme (FP7/2007–2013), grant agreement no. 602450 (IMAGEMEND).
Self-reported.

T1-weighted MRI scans were obtained from a General Electric Medical Systems (Discovery MR750)
3.0T scanner with a 32-channel head coil at Oslo University Hospital using a sagittal T1-weighted fast
spoiled gradient echo (FSPGR) sequence with the following parameters: TR: 8.16 ms; TE: 3.18 ms;
TI: 450 ms; FA: 12°; voxel size: 1.0x1.0x1.0 mm; slices: 188; FOV: 256 x 256 x 188 mm; duration:
288 s.
FreeSurfer version 5.3 was used for data processing.

StenerEOP
Project Name: Youth-TOP/NORMENT EOP

Youth-Top is an ongoing research project focused on longitudinal brain imaging and etiological
outcome factors in Early Onset Psychosis (EOP). Adolescent patients (12-18 years) dagnosed with
EOP are recruited from clinics in the Oslo region, and healthy adolescent controls are randomly
selected from the Norwegian population register in the same catchment area. Youth-TOP is part of the
K.G. Jebsen Centre for Psychosis Research and The Norwegian Centre for Mental Disorders Research
(NORMENT), a collaboration between The University of Oslo, the University of Bergen and Oslo
University Hospital. Funding is provided by the Norwegian Research Council (NFR), the South-
Eastern Norway Regional Health Authority and the KG Jebsen Foundation. The Norwegian Regional
Committee for Medical Research Ethics and the Norwegian Data Protection Agency have approved
the study. All patients, healthy controls, and their parents give written informed consent prior to
inclusion into the project.

Self-report

Magnetic resonance images in Youth-Top were acquired with a 3T GE scanner at Oslo University
Hospital with one major upgrade within the acquisition period. Before upgrade : GE Signa HDxt 3T
scanner, T1-weighted 3D fast spoiled gradient echo sequence (FSPGR; 1mm isotropic voxel size).
After upgrade: GE Discovery MR750 scanner, T1-weighted 3D IR-prepared FSPGR sequence
(BRAVO; 1mm isotropic voxel size). FreeSurfer version 5.3 was used.
TOP3T_0
Project Name: TOP3T and STROKEMRI1 (TOP3T_1)

Participants were recruited from two concurrent projects (STROKEMRI and TOP) using the same
MRI scanner and pulse sequences. For STROKEMRI, subjects were recruited through a newspaper ad
and social media. Exclusion criteria included estimated IQ < 70, previous history of alcohol-and
substance abuse, history of neurologic or psychiatric disease, participants presently on any medication
significantly affecting the nervous system and contraindications for MRI. All participants were self-
sufficient and living independently, and reported no reason to suspect marked cognitive decline or
undiagnosed dementia. For TOP, subjects were invited after a stratified random selection drawn from
the Norwegian National Population Registry. All underwent initial interview where demographic and
clinical information was obtained. Exclusion criteria included a history of head trauma with loss of
consciousness of more than 10 minutes duration, moderate to severe psychiatric or somatic disease,
first-degree relatives with mental illnesses (schizophrenia, bipolar disorder, and major depression
disorder), excessive substance abuse during the last 12 months, or not being able to perform an MRI
scan. Blood samples were taken for standard hospital hematological screening to rule out on-going
illnesses and a urine sample was collected to screen for substance abuse.

Self-reported.

A 3 Tesla a General Electric Medical Systems Signa HDxT scanner at Oslo University Hospital was
used to collect MR data using a 8-channel head coil. A T1-weighted 3D Fast Spoiled Gradient Echo
(FSPGR) sequence was used with the following parameters: repetition time (TR) = 7.8 ms, echo time
(TE) = 2.956 ms, inversion time (TI) = 450 ms, flip angle 12°, matrix = 256 x 256 mm, in-plane
resolution=1x1mm, slice thickness=1.2mm; acquisition time=7min 8s, 166 sagittal slices.
FreeSurfer version 5.3 was used for data processing.

Colm_UCSF
Project Name: A CROSS-SECTIONAL AND LONGITUDINAL FUNCTIONAL MRI STUDY OF
ADOLESCENT DEPRESSION (Colm_UCSF)

Participants provided written informed assent and their parents/legal guardians supplied written
informed consent. The institutional review boards at University of California (UC) San Diego, UC San
Francisco, Rady Children’s Hospital, and the county of San Diego approved this study.
This work was supported by the Brain and Behavior Research Foundation grant (formerly NARSAD)
to T.T.Y. and by a US National Institute of Mental Health (NIMH) grant to T.T.Y. (R01MH085734).
Edinburgh Handedness Inventory

Magnetic resonance imaging data were acquired on a 3T GE MR750 MRI system (Milwaukee, WI) at
UC San Diego. A T1-weighted (T1w) scan (TR/TE=8.1ms/3.17ms, flip angle=12°, 256×256 matrix,
1×1×1mm voxels, 168 sagittal slices) was acquired. Freesurfer version 5.3 was used.
Project Name: A CROSS-SECTIONAL AND LONGITUDINAL FUNCTIONAL MRI STUDY OF

ADOLESCENT DEPRESSION
Colm G. Connolly, PhD 1; Tiffany C. Ho, PhD 1,2 Alan N. Simmons, PhD 6,7; Tony T. Yang, MD,
PhD 1
1 Department of Psychiatry, Division of Child and Adolescent Psychiatry, and Weill Institute for
Neurosciences, University of California, San Francisco, 401 Parnassus Avenue, San Francisco, CA,
USA.
2 Department of Psychology, Stanford University, Stanford, CA, USA.
6 Department of Psychiatry, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA,
USA.
7 Veterans Affairs San Diego Health Care System, La Jolla, CA, USA.
OXUK
Project Name: Oxford Early Onset Psychosis study (OXEOP)

Study of early-onset schizophrenia versus healthy adolescent controls.
MRC funded grant number: G0500092 - Anatomical connectivity in early onset schizophrenia
Ethics : The study was undertaken in accordance with the guidance of the Oxford Psychiatric Research
Ethics Committee and written consent was obtained from all participants (and their parents.
Edinburgh Handedness Questionnaire (Oldfield, 1971)
3. Image Scanning and Data analysis from (Douaud et al., 2007)
The participants underwent the same imaging protocol with a whole-brain T1-weighted and diffusion-
weighted scanning using a 1.5T Sonata MR imager (Siemens, Erlangen, Germany) with a standard
quadrature head coil and maximum 40mT.m 1 gradient capability.
The 3D T1-weighted FLASH sequence was performed with the following parameters: coronal
orientation, matrix 256 256, 208 slices, 1 1 mm2 in-plane resolution, slice thickness 1 mm,
TE/TR=5.6/12ms, flip angle =19 .
...
Douaud, G., Smith, S., Jenkinson, M., Behrens, T., Johansen-Berg, H., Vickers, J., . . . James, A.
(2007). Anatomically related grey and white matter abnormalities in adolescent-onset schizophrenia.
Brain, 130(Pt 9), 2375-2386. doi:awm184 [pii]10.1093/brain/awm184
Oldfield, R. C. (1971). The assessment and analysis of handedness: the Edinburgh inventory.
Neuropsychologia, 9(1), 97-113.
GloriaBPSydney
Project Name: The ‘Bipolar Kids and Sibs’ Study (Bipolar Kids and Sibs)

The ‘Bipolar Kids and Sibs’ Study, is internationally one of the largest and most richly phenotyped
‘high-risk’ prospective studies of young people at high genetic risk of developing bipolar disorder.
The study is approved by the Human Research Ethics Committee of the University of New South
Wales, and complies with the guidelines of the Australian National Health and Medical Research
Council.
All participants are involved in an ongoing longitudinal study of at-risk individuals aged 12 to 30
years, in which those aged between 12 and 21 years at the Sydney site contribute clinical and genetic
data to a National Institute of Mental Health funded collaborative study of an at-risk cohort. This study
is funded by the Australian National Medical and Health Research Council (programme grant
1037196) and the Lansdowne Foundation.
Self-report
Images were acquired with a 3-T Philips Achieva scanner at Neuroscience Research Australia in
Sydney. Each scan started with 1 min of standard scout images to adjust head positioning, followed by
a reference scan to resolve sensitivity variations. A total of 180 T1-weighted anatomic three
dimensional turbo field-echo sagittal images (voxel size=1×1×1mm3 resolution; field of view=256 ×
256 × 180mm3; repetition time/echo time= 5.5/2.5 ms; flip angle = 8°) were acquired to allow
subsequent spatial normalization. FreeSurfer version 5.3 was used.
Orr
Project Name: Cannabis (Addiction_Orr)
Catherine Orr, Hugh Garavan

Resting state fMRI was used to investigate intrinsic brain dynamics and functional connectivity that
discriminated cannabis dependent adolescents (n=17) from matched controls. We identified reduced
interhemispheric connectivity and elevated connectivity within the right hemisphere.
The study was approved by the School of Psychology in Trinity College Dublin and was conducted in
accordance with the declaration of Helsinki.
Self Report
3T, MPRAGE, TR=2300ms, TE=3ms, flip angle=12˚, matrix=256x256x180, voxelsize=0.9mm3

QTIM
Project Name: Queensland Twin Imaging (QTIM) Study

For the Queensland Twin Imaging (QTIM) study, based at QIMR Berghofer Medical Research
Institute, data collection took place from 2007 untill 2012. Most individuals had previously
participated in the Brisbane Adolescent Twin Study (Wright and Martin, 2004). QTIM is funded by
the National Institutes of Health (project ROI HD HD050735; NIH Award 1U54EB020403-01,
subaward no. 56929223) and the NHMRC (1009064, 496682). Ethics approval was given by the
Human Research Ethics Committees of the Queensland Institute of Medical Research, University of
Queensland, and Uniting Health Care. We thank the twins and siblings for their participation, Marlene
Grace and Ann Eldridge for twin recruitment, Aiman Al Najjar and other radiographers for scanning,
and Kerrie McAloney and Daniel Park for research support.

Non-right handed twins were excluded from participating in the study. Data about handedness was
available from the Brisbane Adolescent Twin Study (the Annett Handedness Questionnaire 6-items).
Also, participants were screened for left handedness before coming in for imaging.

The structural MRI scans were obtained at a 4 Tesla (Siemens Bruker), acquiring a 3D structural T1-
weighted image (T1/TR/TE = 700/1500/3.35 ms; flip angle = 8°, slice thickness = 0.9 mm, FOV = 230
mm; 240 or 256 × 256 × 256 matrix depending on the acquisition orientation (81% (838) coronal, 19%
(202) sagittal). Signal inhomogeneity was removed and the scans were registered to standard space
using the Statistical Parametric Mapping (SPM) software package. Images were segmented and
processed with Freesurfer 5.3.
Liza van Eijk
School of Psychology, University of Queensland, Brisbane, Australia

Lachlan T. Strike
Queensland Brain Institute, University of Queensland, Brisbane, Australia
Narelle K. Hansell
Greig I. de Zubicaray
Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane,
Australia
Katie L. McMahon
Centre for Advanced Imaging, University of Queensland, Brisbane, Australia

Paul M. Thompson
Keck School of Medicine, The University of Southern California, Los Angeles, United States
Margaret J. Wright

Keck School of Medicine, The University of Southern California, Los Angeles, United States
NORM_Moscow
Project Name: The R_SCZ database (R_SCZ)

The R_SCZ database has been established in Moscow in 2009 by an initiative of the Laboratory of
Neuroimaging and Multimodal Analysis of the Mental Health Research Center (MHRC, Moscow).
The R_SCZ database has been supported by MHRC and by a research grant from The Russian
Foundation for Basic Research (grant code 15-06-05758 A; grantee Dr. Irina Lebedeva, PhD, DrSci
(biol), the head of the Laboratory of Neuroimaging and Multimodal analysis, MHRC). We would also
like to thank Tolibdzhon A. Akhadov, the head of Department of Radiology, Children's Clinical and
Research Institute of Emergency Surgery and Trauma (Moscow, Russia) for his contribution to the
R_SCZ database and to all persons who kindly participated in this research.
Self-report and self-report confirmed by Annett’s questionnaire for a part of the sample

MRI data were acquired on a Philips Achiva 3T MRI scanner (Philips Medical Systems, Netherlands)
with a 8-channel head coil. The T1-weighted structural brain scans were acquired using a turbo field
echo sequence covering the whole brain. Parameters were as follows: repetition time = 8.2 ms, echo
time = 3.7 ms, flip angle = 8o, SENSE factor = 1.5, field of view = 240 mm, voxel size of 0.83 × 0.83
mm with a slice thickness of 1 mm, no gap. FreeSurfer version 5.3.0 was used.
GEB
Project Name: Gene Environment Brain & Behavior (GEB^2)

Gene Environment Brain & Behavior (GEB^2) aims to investigate association among neural
substrates, cognitive functions, and genetic origins. Two cohorts of college students were recruited
from Beijing Normal University, Beijing, China. Cohort 1 consisted of 294 participants (age: 17–24,
mean age = 20.7; 155 females), and Cohort 2 consisted of 201 participants (age: 18–23, mean age =
20.3; 123 females). Both gene, behavioral and MRI protocols were approved by the Institutional
Review Board of Beijing Normal University. Written informed consent was obtained from all
participants prior to the experiment.
The project was supported by National Natural Science Foundation of China (31230031, 31221003,
31471067, 31470055)
Subjects’s handedness assessment information was acquired through self-report.

All MR imaging was done at the BNU Imaging Center for Brain Research, Beijing, China, on a
Siemens 3T whole-body scanner (MAGENTOM Trio, a Tim system) with a 12-channel phase d-array
head coil. Structural T1-weighted images were acquired with a 3D magnetization-prepared rapid
acquisition gradient echo (MP-RAGE) sequence (TR/TE/TI = 2530/3.39/1100 ms, flip angle = 7°,
FOV = 256 × 256 mm, voxel size = 1.0×1.0×1.33 mm). For volume segmentation and surface
reconstruction, FreeSurfer version 5.0.1 was used.
ASY_results_MuensterCohort
Project Name: Muenster Neuroimaging Cohort

The Muenster Neuroimaging Cohort is a MRI study that has been ongoing since 2009 – focusing on
the biological mechanisms of depression. This study was approved by the ethics committee of the
Medical Faculty of Münster University and was in accordance with the Declaration of Helsinki.
This work was funded by the German Research Foundation (SFB-TRR58, Project C09 to UD) and the
Interdisciplinary Center for Clinical Research (IZKF) of the medical faculty of Münster (grant
Dan3/012/17 to UD).


MRI data were acquired with a 3T scanner Philips Gyroscan Intera with a 3D fast gradient echo
sequence (Acquisition direction anterior-posterior, Number of Slices 320, Slice Gap 0mm,
(0.5x0.5x0.5 mm³ voxel size), TI 814.5 ms, TE 3.4 ms, TR 3.4 ms, FA 9°).
Data was processed with FreeSurfer (version 5.3.0) according to protocols of the ENIGMA
Consortium.
GRADUAL
Project Name: Gene-Brain-Behavior (GBB) Project (GBB_ GRADUAL)

The Gene-Brain-Behavior（GBB）Project was initiated in Southwest University in 2011, which is an
ongoing project exploring the associations among individual differences in brain structure and
function, creativity, and mental health. The project was approved by the Southwest University Brain
Imaging Center Institutional Review Board, and written informed consent was obtained from each
subject. Participants received payment depending on time and tasks completed.This research was
supported by the National Natural Science Foundation of China (31271087; 31470981; 31571137;
31500885), National Outstanding young people plan, the Program for the Top Young Talents by
Chongqing, the Fundamental Research Funds for the Central Universities
(SWU1509383,SWU1509451), Natural Science Foundation of Chongqing (cstc2015jcyjA10106), Fok
Ying Tung Education Foundation (151023) , General Financial Grant from the China Postdoctoral
Science Foundation (2015M572423, 2015M580767), Special Funds from the Chongqing Postdoctoral
Science Foundation (Xm2015037), Key research for Humanities and social sciences of Ministry of
Education(14JJD880009).

Part of subjects were confirmed by Edinburgh Handedness Inventory, and the rest were confirmed by
self report.

Imaging data were collected using an 8-channel head coil on a Siemens 3T Trio scanner (Siemens
Medical Systems, Erlangen, Germany) at the Brain Imaging Center, Southwest University. The same
scanner and sequences were used at both time points. High-resolution, three-dimensional T1-weighted
structural images were obtained using a Magnetization Prepared Rapid Acquisition Gradient-echo
(MPRAGE) sequence (TR/TE =1900 ms/2.52 ms, FA = 9 degrees, FOV= 256 × 256 mm2; slices =
176; thickness = 1.0 mm; voxel size = 1×1×1 mm3). FreeSurfer version 5.3 was used.
SaoPaulo1
Project Name: São Paulo 1 – ESTADO-NARSAD Project

Healthy volunteers matched for age and gender with ADHD patients were recruited through
advertisement in the local community and constituted our HC group. All subjects in the HC group also
underwent clinical interviewing, including the SCID and the K-SADS-PL screening, in order to
exclude psychiatric disorders and previous use of psychopharmacological agents.
In addition to the clinical instruments mentioned above, both patients and HC were screened for
substance use with the Alcohol Use Disorders Identification Test (AUDIT) [30] and the South
Westminster Questionnaire [31]. Diagnostic criteria for substance abuse or dependence were assessed
using the SCID [32]. Handedness was assessed using the Edinburgh inventory [33]. Moreover, a
general medical history, including information about cerebrovascular risk factors, and data on the use
of psychotropic and general medications, was obtained through interviews with patients and/or their
family.
Exclusion criteria for both groups were: substance abuse or dependence (current and lifetime); the
presence of medical conditions or neurological disorders which could affect the central nervous
system; history of mental retardation as assessed by clinical interviews with the patients and a close
relative if necessary; past history of head trauma with loss of consciousness; and contraindications for
MRI scanning.
This study was approved by our local ethics committee: “Comissão de Ética para Análise de Projetos
de Pesquisa” – CAPPesq from the board of the University o Sao Paulo Medical School, and
“Comissão Nacional de Ética em Pesquisa – Conep”. After complete description of the study to the
subjects, written informed consent was obtained.
The present investigation was supported by a 2010 NARSAD Independent Investigator Award
(NARSAD: The Brain and Behavior Research Fund) awarded to Geraldo F. Busatto. Geraldo F.
Busatto is also partially funded by CNPq-Brazil. Marcus V. Zanetti is funded by FAPESP, Brazil (no.
2013/03905-4).

Edimburgh handed ness questionnaire.

Morphological data was acquired using a T1-weighted magnetization-prepared rapid gradient echo
sequence (MPRAGE) using the following parameters: TR = 2,400 ms, TE = 3.65 ms, NEX = 1, field of
view (FOV) = 240 mm, flip angle = 8o, matrix = 192×192 pixels, slice thickness = 1.2 mm (no gap
between slices), voxel size = 1.3×1.3×12 mm, resulting in 160 slices covering the whole brain.
The DTI sequence was acquired using cardiac gating, a 12-channel head coil and parallel imaging.
DTI was based on an echo-planar image (EPI) acquisition and consisted of one image without
diffusion gradient (b = 0 s/mm2) plus diffusion-weighted images (DWI) acquired along 64 non-
colinear directions (b = 1,000 s/mm2) using the following parameters: TR = 8,000 ms, TE = 110 ms,
NEX = 2, FOV = 240 mm, matrix = 120×120 pixels, slice thickness = 2.7 mm (no gap between slices),
voxel size = 2.0×2.0×2.7 mm, resulting in 50 slices covering the whole brain.
The two sequences were acquired in up to 25 minutes. The imaging protocol also included a T2-
weighted turbo spin-echo transaxial sequence (24 slices, slice thickness = 5 mm, 1 mm gap) and a fluid
attenuated inversion recovery (FLAIR) transaxial sequence (24 slices, slice thickness = 5 mm, 1 mm
gap). Individual image inspection of the datasets of each subject was performed visually by an expert
neuroradiologist aiming to identify silent gross brain lesions and artifacts that could interfere with
image processing and analysis.
The T1-weighted images were pre-processed by correcting for signal inhomogeneities followed by
skull-stripping and cerebellum removal. The MNI_N3 Software Package [34], available in:
http://www.bic.mni.mcgill.ca/software/N3/, was used for correcting for signal inhomogeneities. Then,
the skull-stripping and cerebellum removal were performed using a novel automated method known as
Multi-Atlas Skull-Stripping (MASS version 1.0) [35]. Skull-stripping was then manually corrected
when necessary.
FreeSurfer processing: regular automatic reconstruction procedure version 5.3 ran in a Mac OS
platform, followed by the regular ENIGMA quality control protocol.
Just a correction on São Paulo 1: the skullstrip step from FreeSurfer 5.3 was skipped, once another
skullstrip protocol had already been performed before the FreeSurfer's automatic reconstruction.
Ozlem
Project Name: Neuro-ADAPT
Ozlem Korucuoglu
PI: Reinout W. Wiers

This study focuses on differences in neural activity and frontostriatal functional connectivity during an
alcohol-taste cue paradigm between the OPRM1 (rs1799971) AG-genotypes (n =16) and AA-
genotypes (n= 20) in a sample of young healthy individuals (17–21 year olds).
The study was approved by the Ethics Committee of the Faculty of Social and Behavioral Sciences of
the University of Amsterdam.
OK received support for the Neuro-ADAPT study from VICI grant no. 453.08.01 from the
Netherlands Organization for Scientific Research (NWO) awarded to Reinout W Wiers.
Handedness was assessed via self-report.

3T, Gradient Echo, TR=8.17ms, TE=3.8ms, flip angle=8˚, matrix=240x240 x220,
voxelsize=1x1x1mm3
BIG
Project Name: BIG
The Brain Imaging Genetics (BIG) database was established in Nijmegen in 2007. This resource is
now part of Cognomics, a joint initiative by researchers of the Donders Centre for Cognitive
Neuroimaging, the Human Genetics and Cognitive Neuroscience departments of the Radboud
University Medical Center, and the Max Planck Institute for Psycholinguistics. The Cognomics
Initiative is supported by the participating departments and centres and by external grants, i.e. the
Biobanking and Biomolecular Resources Research Infrastructure (Netherlands) (BBMRI-NL), the
Hersenstichting Nederland, and the Netherlands Organisation for Scientific Research (NWO). The
research on BIG also receives funding from the European Community‘s Seventh Framework
Programme (FP7/2007–2013) under grant agreements #602450 (IMAGEMEND) and #602805
(Aggressotype) and from the National Institutes of Health (NIH) Consortium grant U54 EB020403,
supported by a cross-NIH alliance that funds Big Data to Knowledge Centers of Excellence. We
would also like to thank Hans van Bokhoven for his contributions to the Cognomics initiative and to
all persons who kindly participated in this research. In addition, AF Marquand gratefully
acknowledges support from the Language in Interaction project, funded by the NWO under the
Gravitation Programme (grant 024.001.006).
Handedness assessment was based on self-report data.
MRI data in BIG were acquired with either a 1.5 Tesla Siemens Sonata or Avanto scanner or a 3 Tesla
Siemens Trio or TimTrio scanner (Erlangen, Germany). Given that images were acquired during
several smaller scale studies, the parameters used were slight variations of a standard T1-weighted
three-dimensional magnetization prepared rapid gradient echo sequence (MPRAGE; 1.0×1.0×1.0 mm
voxel size). FreeSurfer version 5.3 was used.
Xiang-Zhen Kong; Tulio Guadalupe

Language and Genetics Department, Max Planck Institute for Psycholinguistics
Simon E. Fisher; Clyde Francks

Language and Genetics Department, Max Planck Institute for Psycholinguistics; Donders Institute for
Brain, Cognition and Behavior, Radboud University
Cousijn
Project Name: Cannabis Prospective (Addiction_Cousijn)
PIs
Janna Cousijn
Department of Developmental Psychology, University of Amsterdam, Amsterdam, the Netherlands
Anna E. Goudriaan
Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The
Netherlands
Arkin Institute of Mental Health, the Netherlands

This study investigated the predictive role of neurocognitive functions in the progression from
cannabis use to dependence in at-risk young adults. The Medical Ethics committee of the Academic
Medical Center of the University of Amsterdam approved the study.
JC & AG received funding for the Cannabis Prospective study from ZonMW grant no.31180002 from
the Netherlands Organization for Scientific Research (NWO)

Self-report

3T, Turbo Field Echo, TR=9.6 ms, TE=4.6ms, flip angle 8°, matrix=256×256x182, voxel size
=1x1x1.2mm3
CAMH_ASD
Project Name: CAMH

The CAMH dataset was collected in Toronto with support from the CAMH Foundation and the
Canadian Institutes of Health Research.
Self report confirmed by Edinburgh Hand Dominanace Questionnaire
The MR images at CAMH were acquired using an 8-channel head coil on a 1.5-T system (EchoSpeed;
General Electric Medical Systems). Axial inversion recovery–prepared spoiled gradient recall (SPGR)
images were acquired using a 1.5-mm-thick slice acquisition with the following image parameters:
echo time (TE), 5.3 milliseconds; repetition time (TR), 12.3 milliseconds; time to inversion, 300.0
milliseconds; and flip angle, 20°, final voxel size 0.8x0.8x1.5mm. FreeSurfer version 5.3 was used.
ClarissaBr
Project Name: The Brazilian Institute of Neuroscience and Neurotechnology (BRAINN)

The Brazilian Institute of Neuroscience and Neurotechnology (BRAINN) was launched in 2013 by
FAPESP (SÃO PAULO RESEARCH FOUNDATION, grant 2013/07559-3) as a Research,
Innovation and Dissemination Center (RIDC).
The central biological questions of our project are the investigation of basic mechanisms that lead to
epilepsy and stroke and the injury mechanisms that follow the disease onset and progression and are
related to prevention, treatment and rehabilitation. Our goals are to develop new methods and
techniques to improve the understanding of mechanisms of damage, plasticity and repair in epilepsy
and stroke; and to apply these results to improve diagnosis, prevention and treatment. This initiative
foresees the creation of a new environment for scientific and technological development, new clinical
applications, education and interaction with the business sector.
This research proposal is outstanding as it is clinically important, realistic and scientifically highly
original, combining genetics, neurobiology, pharmacology, neuroimaging, computer sciences,
robotics, physics and engineering. Results will benefit patients with epilepsy, stroke and other
prevalent diseases, and contribute substantially to ongoing scientific discussions within neurology,
psychiatry, and cognitive neuroscience.

For most of the subjects, we used self-report information. Some subjects had confirmation by
Edinburgh Handedness Inventory.

MRI data were acquired with a single 3T PHILIPS scanner (ACHIEVA-INTERA), with similar
protocol (T1 weighted, 1x1x1mm). All images were processed with FreeSurfer version 5.3
ClinG_sample
Project Name: Clinical Neuroscience Göttingen Study (CliNG)

The CliNG database was established in Göttingen, Germany between 2008 – 2015. Recruitment for
the CliNG study sample was partially supported by the Deutsche Forschungsgemeinschaft (DFG) via
the Clinical Research Group 241 ‘Genotype-phenotype relationships and neurobiology of the
longitudinal course of psychosis’, TP2 (PI Gruber; http://www.kfo241.de; grant number GR 1950/5-
1).

Self report.

MRI data in CliNG were acquired with a 3 Tesla Siemens TIM Trio scanner (Erlangen, Germany).
Following acquisition parameters were used: T1-weighted, 3D magnetization prepared rapid gradient
echo sequence (MPRAGE) (TR/TE/TI/FA=2250 ms/3.26 ms/900 ms/9°; image matrix = 256 x 256;
duration 8 min and 26 sec) generating 192 sagittal slices with a voxel size of 1 mm3. Version of
FreeSurfer: 5.3.
EstherCOBRE
Project Name: COBRE

Informed consent was obtained from all subjects according to institutional guidelines at the University
of New Mexico Human Research Protections Office, and all data were anonymized prior to group
analysis.
This research was supported by NIH1R01-EB006841, NIH1R01-EB005846, NIH2R01-EB000840,
NIH1 P20 RR021938-01 and DOEDEFG02-08ER64581 (to VDC); the national high tech
development plan (863 plan) 2015AA020513 (to JS); R01 MH65304 and VA CSR&D IIR-04-212-3
(to JMC). TW is supported by the Netherlands Organization for Health Research and Development
(ZonMw) TOP project number 91211021 and the Simons Foundation Autism Research Initiative
(SFARI - 307280).
Self-report

All images were collected on a single 3-Tesla Siemens Trio scanner with a 12-channel radio frequency
coil. High resolution T1-weighted structural images were acquired with a five-echo MPRAGE
sequence with TE = 1.64, 3.5, 5.36, 7.22, 9.08 ms, TR = 2.53 s, TI = 1.2 s, flip angle = 7°, number of
excitations = 1, slice thickness = 1 mm, field of view = 256 mm, resolution = 256 × 256.
EstherMCIC
Project Name: MCIC

The Mind Clinical Imaging Consortium (MCIC) study of schizophrenia (Gollub et al., 2013) was
established to further the understanding of the underlying pathophysiological mechanisms of
schizophrenia through structural magnetic resonance imaging (MRI) and a large number of clinical
and neurophysiological measures. The MCIC is comprised of investigators from academic
departments located at four research sites: the University of New Mexico (UNM), the University of
Minnesota (UMN), Massachusetts General Hospital (MGH), and the University of Iowa (UI). Imaging
and behavior data from the MCIC study are available via the collaborative informatics and
neuroimaging suit (COINS) data exchange (http://coins.mrn.org/dx; Wood et al., 2014).
All subjects provided informed consent to participate in the study that was approved by the human
research committees at each of the sites.
This work was supported primarily by the Department of Energy DE-FG02-99ER62764 through its
support of the Mind Research Network (MRN, formerly known as the MIND Institute) and the
consortium as well as by the National Association for Research in Schizophrenia and Affective
Disorders (NARSAD) Young Investigator Award (to SE) as well as through the Blowitz-Ridgeway
and Essel Foundations, and through NWO ZonMw TOP 91211021, the DFG research fellowship (to
SE), the Mind Research Network, National Institutes of Health through NCRR 5MO1-RR001066
(MGH General Clinical Research Center), NIMH K08 MH068540, the Biomedical Informatics
Research Network with NCRR Supplements to P41 RR14075 (MGH), M01 RR 01066 (MGH), NIBIB
R01EB006841 (MRN), R01EB005846 (MRN), 2R01 EB000840 (MRN), 1RC1MH089257 (MRN), as
well as grant U24 RR021992, P20RR021938/P20GM103472 and R01MH094524.

Handedness were recorded using the Hollingshead index (Hollingshead, 1965) and Annett Scale of
Hand Preference (Annett, 1970), respectively.

A T1-weighted structural MRI with a coronal gradient echo sequence was acquired at each of the four
sites using 1.5T Siemens Sonata (MGH, UI, UNM) or a 3T Siemens Trio (UMN). The following
parameters were used: TR=2530ms for 3T, TR=12ms for 1.5T; TE=3.81 for 3T, TE=4.76ms for 1.5T;
TI=1100 for 3T; Bandwidth=180 for 3T, Bandwidth=110 for 1.5T; voxel size: 0.625×0.625; slice
thickness 1.5mm; FOV, 256×256×128 cm matrix; FOV=16cm; NEX=1 for 3T, NEX=3 for 1.5T.
According to the guidelines developed by the biomedical informatics research network (BIRN) test
bed for morphometry (Jovicich et al., 2006, 2009) a preceding study was implemented with human
phantoms to establish cross-site MRI acquisition calibration and reliability.
ASY_results_FOR2107
Project Name: FOR2107
Project Name: FOR2107 (Münster)

As central project of FOR2107, this study collects MRI data in parallel in Marburg and Münster –
more subprojects (e.g. biodata, animal studies) are affiliated.
This study was approved by the ethics committee of the Medical Faculty of Münster University and
was in accordance with the Declaration of Helsinki. This work was funded by the German Research
Foundation (DFG, grant FOR2107 DA1151/5-1 and DA1151/5-2 to Udo Dannlowski; HA7070/2-2 to
Tim Hahn).

MRI data in Muenster were acquired with a 3T Siemens PRISMA including a T1-weighted mprage
whole-brain scan (Acquisition direction anterior-posterior, Number of Slices 192, Slice Gap 0mm
(1.0x1.0x1.0 mm³, TI 900ms, TE 2.28 ms, TR 2130.0 ms, FA 8°)
Data was processed with FreeSurfer (5.3.0) according to protocols of the ENIGMA Consortium.
Project Name: FOR2107 (Marburg)

As central project of FOR2107, this study collects MRI data in parallel in Marburg and Münster –
more subprojects (e.g. biodata, animal studies) are affiliated.
This study was approved by the ethics committee of the Medical Faculty of Marburg University and
was in accordance with the Declaration of Helsinki.
This work was funded by the German Research Foundation (DFG, grant FOR2107 KI 588/14-1 to TK
and KO4291/3-1 to AK) .

MRI data in Marburg were acquired with a 3T Siemens Magnetom TiroTim syngo including a T1-
weighted mprage whole-brain (Acquisition direction anterior-posterior, Number of Slices 176, Slice
Gap 0.5mm (1.0x1.0x1.0 mm³, TI 900ms, TE 2.26 ms, TR 1900 ms, FA 9°).
Data was processed with FreeSurfer (5.3.0) according to protocols of the ENIGMA Consortium.
NUIG
Dataset Name: NUIG
Project Name: The Galway First Episode Psychosis Study

The Galway First Episode Psychosis Study explores changes in brain structure and functioning
associated with psychotic illness at an early stage of illness onset. This NUI Galway study was
supported by the NUI Galway Millennium Fund and grant funding from the Health Research Board
(HRA_POR/2011/100).
Self-reported.

MRI data in the Galway Bipolar Study were acquired on a 1.5T Tesla Siemens Magnetom Symphony,
software platform Numaris 2004A, running VA30A software (Erlangen, Germany). The parameters
used were T1-weighted three-dimensional magnetization prepared rapid gradient echo sequence
(MPRAGE; 0.45 x 0.45 x 0.9 mm voxel size). FreeSurfer version 5.3 was used.
Project Name: The Galway Bipolar Study: An investigation into neurobiological markers in patients
with euthymic bipolar disorder

The Galway Bipolar Study explores structural and diffusion magnetic resonance imaging changes and
the potential links with clinical and functional factors. This NUI Galway study was supported by the
NUI Galway Millennium Fund and grant funding from the Health Research Board
(HRA_POR/2011/100).
Self-reported.
MRI data in the Galway Bipolar Study were acquired on a 1.5T Tesla Siemens Magnetom Symphony,
software platform Numaris 2004A, running VA30A software (Erlangen, Germany). The parameters
used were T1-weighted three-dimensional magnetization prepared rapid gradient echo sequence
(MPRAGE; 0.45 x 0.45 x 0.9 mm voxel size). FreeSurfer version 5.3 was used.
Genevieve McPhilemy, Theophilus Akudjedu, Giulia Tronchin, Colm McDonald, Dara M. Cannon
Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory,
NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National
University of Ireland Galway, H91 TK33 Galway, Ireland.
01_Cheng_1.5T
Project Name: Yuqi Cheng 1.5T (OCD_Cheng_1.5T)
The database was established in Kunming in 2007. This resource was approved by the ethics
committee of the First Affiliated Hospital of Kunming Medical College. This study was supported the
Funding of Yunnan Provincial Health Science and Technology Plan (2010NS016, 2011WS008), the
united founding of Yunnan Administration of Science & Technology and Kunming Medical
College(2011FB167),
Self report confirmed by Edinburgh Handedness Inventory

MRI data were acquired with a 1.5 Tesla GE Signa Excite scanner. The parameters used were matrix
matrix matrix 256x256, 172 slices and, voxel size 0.93x0.93x0.9 mm. Images were processed with
FreeSurfer version 5.3.
SaoPaulo3
Project Name: Wellcome Study

Incidence population-based case-control study of psychosis, using a determined geographical area in
São Paulo, Brazil. For the control group, a total of 114 people from the catchment area were recruited
for MRI (controls are patients’ neighbors), but 11 were excluded owing to the presence of silent gross
brain lesions and 9 owing to artifacts during image acquisition, resulting in a final sample of 94
controls.
All participants were screened for substance use with the Alcohol Use Disorders Identification Test
(AUDIT; Saunders et al, 1993) and the South West- minster Questionnaire (Menezes et al, 1996).
Diagnostic criteria for substance abuse or dependence were assessed using the SCID (First et al,
1995). Handedness was assessed with Annett’s Hand Preference Questionnaire (Annett, 1970). The
study was approved by local ethics committees and written informed consent was obtained from all
participants.
This study was funded by the Wellcome Trust, UK.
Handedness was assessed with Annett’s Hand Preference Questionnaire (Annett, 1970).
Imaging data were acquired using two MRI scanners (at the Clinics Hospital of the University of Sa ̃ o
Paulo 1.5 T GE Signa scanner, General Electric, Milwaukee Wisconsin, USA). In total 72 people with
psychosis and 57 controls were investigated using scanner 1 and 50 people with psychosis and 37
controls using scanner 2. Exactly the same acquisition protocols were used (a T1-SPGR sequence
providing 124 contiguous slices, voxel size 0.8660.8661.5 mm, echo time 5.2 ms, resolution time
21.7 ms, flip angle 20, field of vision 22, matrix 2566192).
FreeSurfer processing: regular automatic reconstruction version 5.3 procedure ran in a Mac OS
platform, followed by white matter mask correction for regions with poor cortical delineation (mainly
in the temporal lobe; majority of subjects) and then by the regular ENIGMA quality control protocol.
1.5T_Adults_Lateralization
1.5 Tesla - 20 Subjects (>18 years old - adults)

(NSIOCDS_1.5T_Adults)
1.5T Adult – (Siemens Vision): matrix 256X160, 160 slices, voxel size 0.98X0.98X1 mm
3T_Adults_Lateralization
3 Tesla - 171 Healthy Subjects (>18 years old - adults)

(NSIOCDS_3T_Adults)
3T Adult - (Siemens Skyra): matrix 256X256, 192 slices, voxel size 1.0 X 1.0 X 1.0 mm;
EStein
Project Name: EStein (Addiction_EStein)
Cocaine:
Eliot A. Stein, Elisabeth C. Caparelli

Data was collected to study cocaine dependence. All these studies were IRB approved where
participants signed an IRB approved consent form. Approval for data/results sharing with the
ENIGMA consortium was provided by the Office of Human Subjects Research Protections.
Data collection was supported by the Intramural Research Program of NIDA/NIH.

3T, MPRAGE, TR=1900ms, TE=3.51ms, flip angle= 9˚, matrix=256x192x208, voxel size
=1x1x1mm3
Smokers:
Eliot A. Stein, Elisabeth C. Caparelli

Data was collected to study cocaine dependence. All these studies were IRB approved where
participants signed an IRB approved consent form. Data provided for this collaboration that came
from protocol that are already closed, are covered by a repository protocol that covers data analysis.
Approval for data/results sharing with the ENIGMA consortium was provided by the Office of Human
Subjects Research Protections.
Data collection was supported by the Intramural Research Program of NIDA/NIH.

Information about the dominant hand depending on the study came from: Edinburgh Handedness
Inventory, question regarding the dominant hand at either phone screening or during physical and
history questioner.
3T, MPRAGE, TR=2500ms, TE=4.38ms, flip angle=8˚, matrix=256x192x160 voxel size=1x1x1mm3

London
Project Names: Addiction_London
Early methamphetamine abstinence: fMRI and Cognition
Neural systems, inhibitory control, and methamphetamine dependence

Authors:
Edythe D. London, Angelica M. Morales
These projects examined how structural and functional brain abnormalities were associated with
attention, working memory (R01DA015179, EDL), response inhibition, cognitive flexibility and
decision making in methamphetamine users (R01DA020726, P20DA022539, EDL). Additional
support for these projects came from the Thomas P. and Katherine K. Pike Chair in Addiction Studies
and the Endowment from the Marjorie Greene Family Trust (EDL).

1.5T, MPRAGE, TR=1900ms, TE=4.38ms, flip angle=15˚, matrix=256x256x160, voxel
size=1x1x1mm3
Luijten
Project Name: DABIS (Addiction_Luijten)
Maartje Luijten, Dick Veltman
Maartje Luijten, PhD

Behavioural Science Institute, Radboud University
PO Box 9104, 6500 HE Nijmegen, Montessorilaan 3, the Netherlands

This project investigated whether brain activation associated with attentional bias as measured with
fMRI is depending on dopamine transmission using a placebo controlled double blind randomized trial
with haloperidol. ML & DV received funding for the DABIS study from VIDI grant no.016.08.322
from the Netherlands Organization for Scientific Research (NWO) awarded to Ingmar H A Franken.
The study was conducted in accordance with the Declaration of Helsinki and all procedures were
carried out after participants signed informed consent. The ethics committee of Erasmus MC
University Medical Centre Rotterdam approved this study.
Self-report – indeed self report

3T, Inversion Recovery Fast Spoiled Gradient Recalled Echo (FSPGR), TR=10.6ms, TE=2.2ms,
matrix=416x256x 192, voxel size = 1x1x1mm3
Paulus
Project Name: Relapse (Addiction_Paulus)
Martin Paulus, Scott Mackey

The study was designed to identify behavioral and neural predictors of relapse in treatment seeking
methamphetamine dependent patients
MP received funding from NIMH: R01 DA018307

Approval for the study was obtained from the University of California San Diego Human Research
Protections Program. Each subject gave informed consent prior to participating.

3T, Spoiled gradient recalled (SPGR), TR=8 ms, TE=3ms, flip angle=12°, matrix=192× 256x172,
voxel size=0.97x 0.97x1mm3
Yucel
Project Name: Addiction_Yucel
Chronic Cannabis- Memory:
Murat Yucel
The goal of this study was to examine the impact of long-term cannabis use on human brain structure
and function.
Authorship should include Murat Yucel, Nadia Solowij, Valentina Lorenzetti and Yann Chye
I can confirm that local IRB approval was obtained. That is, this study was approved by the local
Human Research and Ethics Board, and all participants provided written, informed consent before
participation.
This study was funded by National Health and Medical Research Council (NHMRC) of Australia
(Project Grant 459111). MY was supported by a National Health and Medical Research Council
Fellowship (#1117188) and the David Winston Turner Endowment Fund.
EHI
3T, MPRAGE, TR=1900ms, TE=2.15ms, flip angle=, matrix=256x256x176, voxelsize=1x1x1mm3
Chronic Cannabis:
Nadia Solowij
This study recruited an exceptionally well-characterized sample of very heavy long-term cannabis
users and matched controls (as well as people with schizophrenia with and without comorbid very
heavy long-term cannabis use), with the aim to assess brain structure and function.
The study was supported by grants from the Clive and Vera Ramaciotti Foundation (NS), the
Schizophrenia Research Institute using infrastructure funding from NSW Health (NS), the University
of Wollongong (NS), the National Health and Medical Research Council Program Grant (350241
MY), Project Grant (459111 NS) and Clinical Career Development Award (509345 MY), and an
Australian Research Council Future Fellowship (FT110100752 NS).
The study was approved by the University of Wollongong and South East Sydney and Illawarra Local
Health Disctrict Human Research Ethics Committee. Participants provided written informed consent
to participate in the study.

3T, Spoiled Gradient-Recalled Echo, TR=6.4ms, TE=2.9ms, flip angle=8˚, matrix= 256x256x180,
voxel size=1x1x1mm3
Key authorships: Solowij, Yücel
Chronic cannabis users (Barcelona):
Rocio Martin-Santosa, Albert Batallaa,b

1. Department of Psychiatry and Psychology, Hospital Clínic, IDIBAPS, CIBERSAM, University of
Barcelona, Barcelona, Spain.
2. Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud
University Medical Center, Nijmegen, The Netherlands.

Chronic cannabis users who began using cannabis before 16 years of age were matched to healthy
volunteers in terms of age, educational level and IQ. Participants were male Caucasians, aged between
18 and 30 years.
Funding: This study has been done in part with Spanish grants: Plan Nacional sobre Drogas,
Ministerio de Sanidady Consumo PNSD/2011/050 and PNSD2006/101; and the support of DIUE of
Generalitat de Catalunya SGR2009/1435.
The study was approved by the Ethical and Clinical Research Committee of CEIC-Parc de Salut Mar,
Barcelona, Spain.
Self-report.

1.5T, Fast Spoiled Gradient Inversion-Recovery, TR=11.8 ms, TE=4.2ms, flip angle= 15˚,
matrix=256x256x124, voxel size=1.17x1.17x 1.2mm3
ADS:
Nick Allen, Sarah Whittle

The broad aim of the ADS was to prospectively examine biopsychosocial risk and protective factors
for emotional and behavioral problems during adolescence. 415 early adolescents were selected (from
a community sample of >2000) into the study based on temperamental risk/resilience. 245 adolescents
consented to participate in longitudinal research. These adolescents were invited to participate in 4
assessment waves from age 12 to 19.
This research was supported by grants from the Colonial Foundation, the National Health and Medical
Research Council (NHMRC; Australia; Program Grant 350241), the Australian Research Council
(ARC; Discovery Grants DP0878136 & DP1092637), and The University of Melbourne.
The ADS was approved by the Human Research Ethics Committee at The University of Melbourne,
Australia. Consent to participate in the study was obtained from both the child and at least one parent
at all time points.


3T, gradient echo volumetric acquisition, TR=36ms, TE=9ms, flip angle=35˚, matrix=410x410, voxel
size=1.5x0.49x0.49 mm3
Kwon_3T
Project Name: Seoul III dataset (previously named as Kwon_3T)

The Seoul III dataset was acquired from the OCD clinic at Seoul National University Hospital
(SNUH). This study was approved from the Institutional Review Board of SNUH, and was supported
by National Research Foundation of Korea grant funded by the Ministry of Education, Science and
Technology (MEST) of the Republic of Korea (2011-0015639 and 2012-0005150), a grant of
the Korea Health Technology R&D Project, Ministry of Health & Welfare of the Republic of
Korea (A110094), and Basic Science Research Program through the National Research Foundation of
Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (2013R1A2A1A03071089).
Not included in this analysis.
In the Seoul III dataset, the whole-brain anatomy was assessed using high-resolution T1-weighted,
three-dimensional Magnetization Prepared Rapid Gradient Echo (TR = 1,670 ms; TE = 1.89 ms;
FOV = 250 mm; FA = 9°; voxel size = 1 × 0.977 × 0.977 mm) at 3-Tesla scanner (Siemens Magnetom
Trio, Erlangen, Germany). For MRI data processing, FreeSurfer version 5.3 was used.
KwonNMC_15T
Project Name: Seoul II dataset (previously named as KwonNMC_15T)

The Seoul II dataset was acquired from the OCD clinic at Seoul National University Hospital (SNUH).
This study was approved from the Institutional Review Board of SNUH, and was supported by grants
(M103KV010012-06K2201-01210, 2009K001270, and 2010K000817) from Brain Research Center of
the 21st Century Frontier Research Program funded by the Ministry of Science and Technology of the
Republic of Korea, a grant (M10644020003-08N4402-00310) from the Cognitive Neuroscience
Program of the Korean Ministry of Science and Technology of the Republic of Korea, the Korea
Research Foundation grants funded by the Korean Government (KRF-2007-313-E00306 and KRF-
2008-313-E00341), World Class University program through the Korea Science and Engineering
Foundation funded by the Ministry of Education, Science and Technology (R31-10089, and R32-
10142), a grant from the Seoul National University Hospital Research Fund (04-2008-104), and a
grant from the National Research Foundation of Korea (2012-0005150) funded by the Ministry of
Education, Science and Technology (MEST) of the Republic of Korea.

Images for the Seoul II dataset were acquired in axial plane using a 1.5-T scanner (Avanto, Siemens,
Erlangen, Germany) and T1-weighted 3-D magnetization-prepared rapid-acquisition gradient echo
(MPRAGE) sequence. Parameters were as follows: echo time/repetition time = 4.76/1160 msec; flip
angle = 15°; field of view = 230 mm; voxel size = 0.45 × 0.45 × 0.9 mm.
KwonSNU_15T
Project Name: Seoul I dataset (previously named as KwonSNU_15T)

The Seoul I dataset was acquired from the OCD clinic at Seoul National University Hospital (SNUH).
This study was approved from the Institutional Review Board of SNUH, and was supported by the
Korean Research Foundation (1998-003-F00172), Korean Health Research and Development Grant
(HMP-98-N-2-0029), Korea Research Foundation Grant (KRF-2001-044-F00182), Korean Research
Foundation (2001-041-F00182), Seoul National University Hospital Research Fund (11-2003-001),
and Brain Research Center of the 21st Century Frontier Research Program by Ministry of Science and
Technology of Republic of Korea (M103KV010007 04K2201 007 10).
MRI data in Seoul I dataset were acquired with three-dimensional T1-weighted spoiled gradient echo
sequence on a 1.5 Tesla GE SIGNA Scanner (GE Medical System, Milwaukee, USA). Imaging
parameters were as follows: 1.5 mm sagittal slices; echo time=5.5 ms; repetition time=14.4 ms;
rotation angle=20°; field of view = 21 × 21 cm; and a matrix of 256 × 256. For MRI data processing,
FreeSurfer version 5.3 was used.
BILGIN
Project Name: The BIL&GIN database

The BIL&GIN was designed to allow an in-depth exploration of hemispheric specialization and of its
variability in human. A local ethics committee (CCPRB Basse-Normandie) approved the experimental
protocol. Participants gave their informed, written consent, and received compensation for their
participation in the study. All participants were free of brain abnormalities as assessed by inspection of
their structural T1-MRI scans by a trained radiologist.

• Self reported handedness: Participants were asked whether they considered themselves as
either right-handed, left-handed, or forced left-handed.
• Manual preference strength: Manual preference strength was evaluated using the Edinburgh
inventory score, broom item discarded).
• Manual skill: We used the finger-tapping test for assessing manual skill.

• BIL&GIN structural MRI dataset was acquired with a 3T Tesla Philips ACHIVA scanner
(Philips Medical Systems, Best, The Netherlands). The acquisition protocol included a high-resolution
3D T1-weighted sequence (3D-FFE-TFE; TR = 20 ms; TE = 4.6 ms; flip angle = 10°; inversion time =
800 ms; turbo field echo factor = 65; sense factor = 2; matrix size = 256 × 256 × 180 mm3; 1mm3
isotropic voxel size).
• Reconstruction of cortical surfaces and measurement cortical thickness and surface area were
performed using the FreeSurfer 5.3.0 image analysis suite. FreeSurfer constructs models of the cortical
surface (white and pial). Each pial and white surface on each axial, sagittal and coronal section of each
participant were visually checked twice and identified segmentation errors were reported in 48 cases
(11%). A correction procedure consisting of manually adding an average of 9 control points (SD, 7) in
the misclassified white matter was applied in these 48 cases. The automatic FreeSurfer segmentation
procedure was then re-applied on these individuals, resulting in an accurate surface reconstruction
after a novel round of quality control visual check.
TOP15T
Project Name: TOP1.5T

All participants were recruited between 2003 and 2009 as part of an ongoing study of psychotic
disorders (Thematically Organized Psychosis (TOP) study). After complete description of the study,
all participants gave informed consent to participate. The study was approved by the Regional
Committee for Medical Research Ethics and the Norwegian Data Inspectorate. Exclusion criteria for
all participants were a history of moderate or severe head injury, neurological disorder, IQ <65, and
age outside the range 18 to 65 years. Participants were excluded if they had abused cannabis within the
last 3 months, if they had a dependency on the drug, if they or any of their first-degree relatives had a
lifetime history of severe psychiatric disorder, or if they had a history of medical problems thought to
interfere with brain function.
Self-reported.

T1-weighted MRI data were acquired on a 1.5 T Siemens Magnetom Sonata (Siemens Medical
Solutions, Erlangen, Germany) using a standard head coil at Oslo University Hospital and a 3D T1-
weighted magnetization prepared rapid acquisition gradient echo (MPRAGE) sequence with the
following parameters: TR/TE/TI/FOV/FA/matrix = 2730 ms/3.93 ms/1000 ms/240 mm/7°/192 × 256;
voxel size 1.33 × 0.94 × 1 mm, 160 sagittal slices. The sequence was repeated twice and the two scans
were averaged after rigid registration to increase signal-to-noise ratio. FreeSurfer version 5.3 was used
for data processing.
SaudEPIGEN
Project Name: EPIGEN-Ireland
Analysts: Saud Alhusaini and Christopher D. Whelan
Principal Investigators: Gianpiero L. Cavalleri, Colin P. Doherty, Norman Delanty

The Epilepsy Genetics (EPIGEN) Consortium was established to undertake genetic mapping analyses
to enable the detection of variants that influence the development and treatment of common forms of
epilepsy. The EPIGEN-Ireland study consisted of epilepsy cohorts recruited from specialized epilepsy
clinics at Beaumont Hospital at St. James’s Hospital, Dublin, Ireland. Patients were mostly of Irish
ethnicity. As part of the study, epilepsy patients as well as healthy control subjects underwent detailed
phenotyping that included brain imaging. The work was supported by research grants from the Science
Foundation Ireland (Research Frontiers Program award 08/RFP/GEN1538) and Brainwave–the Irish
Epilepsy Association.
Self reports supported by Edinburgh Handedness Inventory

MRI data were acquired on 3 Tesla scanner (Achieva, Philips Medical Systems, The Netherlands) at
the Centre for Advanced Medical Imaging, St. James’s Hospital. A three-dimensional (3D) T1-
weighted turbo field echo sequence (TR/TE = 8.5/3.9 ms, flip angle = 8° turbo factor n = 240, field of
view = 25.6x25.6 cm2) with 160 slices and an isotropic spatial resolution of 1.0 mm3 was used to
acquire the images. FreeSurfer version 5.3.0 was used to process MR images.
MatthewSacchet
Project Name: Stanford

The Stanford dataset was established with the support of NIMH Grant R01MH59259 to Ian Gotlib,
and the National Science Foundation Integrative Graduate Education and Research Traineeship (NSF
IGERT) Recipient Award 0801700 and National Science Foundation Graduate Research Fellowship
Program (NSF GRFP) DGE-1147470 to Matthew Sacchet.
Self-report

MRI data were acquired using a 1.5T GE Signa Excite MR system. Whole-brain T1-weighted (T1w)
images were collected using a spoiled gradient echo (SPGR) pulse sequence (116 sagittal slices;
through-plane resolution = 1.5 mm; in-plane resolution = 0.86 x 0.86 mm; flip angle = 15 degrees;
repetition time [TR] = 8.3-10.1 ms; echo time [TE] = 1.7-3.0; inversion time [TI] = 300 ms; matrix =
256 x 192). During the period of several years in which data were collected, no major scanner
upgrades that would influence SPGR images were undertaken. FreeSurfer version 5.3 was used to
process the T1w images.
AnneU
Project Name: CIAM (South Africa)
Research Team: Anne Uhlmann, Henk S Temmingh, Dan J Stein, Fleur M Howells (PI)
The CIAM study was conducted at the University of Cape Town, Department of Psychiatry and
Mental Health, and was supported by the Department of Psychiatry and Mental Health and University
Research Committee, University of Cape Town, South Africa and the National Research Foundation
South Africa.

MRI data were acquired with a 3 Tesla Siemens Allegra scanner (Erlangen, Germany), using a 3D T1-
weighted multiecho magnetization prepared rapid acquisition gradient echo (MEMPRAGE) sequence.
Parameters were as follows: TR=2530ms; TE=1.53, 3.21, 4.89, 6.57ms; flip angle=7°, voxel
size=1.3×1.0×1.3 mm, 128 slices. FreeSurfer version 5.3 was used for analysis.
HMS_sample
Project Name: Homburg Multidiagnosis Study (HMS)

The HMS database was established in Homburg, Germany between 2004-2007.
Self-report confirmed by Edinburgh Handedness Inventory.

MRI data in HMS were acquired with a 1.5 Tesla Siemens Sonata scanner (Erlangen, Germany).
Following acquisition parameters were used: T1-weighted, magnetization prepared rapid gradient echo
sequence (MPRAGE) (TR/TE/TI/FA=1900 ms/4.0 ms/700 ms/15°; image matrix = 256 x 256)
generating 176 consecutive sagittal slices with a voxel size of 1 mm3. Version of FreeSurfer: 5.3.
JPCapeTown
Project Name: Delineating endophenotypes of obsessive-compulsive disorder and hair-pulling
disorder (HPD, or trichotillomania): An integrated pharmacological, neurocognitive, genetic and
imaging study (JPCapeTown)

This ongoing project draws on the expertise of 2 teams, in South Africa (UCT and SU), and the UK
(Cambridge University). This is a case-control cross-sectional study including resting-state functional
magnetic resonance imaging, structural brain imaging, fMRI, magnetic resonance spectroscopy (MRS)
and Diffusion Tensor Imaging (DTI). In addition, all participants undergo neurocognitive assessments
and venesection, with their DNA stored for genetic analysis. Thus it is aimed to investigate the role of
polymorphisms in specific candidate genes in accounting for variance in neuroimaging and cognitive-
affective data in 4 participant groups (OCD, HPD, OCD relatives, healthy controls), 50 in each group);
and to assess the differences between groups in terms of performance on behavioral tasks.
This work was supported by the Medical Research Council of South Africa, the Obsessive-
Compulsive Foundation (Dan J. Stein), the National Research Foundation of South Africa (Christine
Lochner), and an unrestricted grant from Lundbeck H/S, and we acknowledge the contribution of our
research assistants.
The study protocol and patient information and consent forms have been approved by the HREC of the
Faculty of Health Sciences, Stellenbosch University, as well as by the Ethics Committee of the
University of Cape Town (UCT) (SU HREC reference number N14/05/053; UCT HREC reference
number: 770/2014). Approval was obtained for the procedural and ethical details of the study.
The study is conducted in accordance with the guidelines of the International Conference on
Harmonisation Good Clinical Practice Guidelines (ICH/GCP, 1996), The Declaration of Helsinki
(Edinburgh 2000) and The Medical Research Council of South Africa’s guidelines (2002) on the
ethical conduct of research studies in humans.
Self-report confirmed by Edinburgh Handedness Inventory.

All OCD/HPD cases, first-degree relatives of OCD patients, and normal controls are imaged using
MRI using voxel based morphometry (VBM) or Freesurfer V5.3, rigorous methods for assessing the
volume and thickness of brain regions likely involved in mediating cognitive tasks. Those with
clinically relevant structural abnormalities are excluded. Sequences include ME-MPRAGE (T1), T2,
FLAIR, rs fMRI, 3 fMRI tasks, DTI (AP-PA) and MRS.
Scanner information: 2 scanners (Tygerberg from 2007 – 2014; UCT from 2014 onwards):
T1 MPRAGE information:
Tygerberg: Siemens Magnetom Allegra 3T; voxel size (1.0×1.0×1.0 [mm] ), slices (160), FoV read
(256mm), slice thickness (1mm), distance factor (50%), TR (2530.0 ms), Base resolution (256), scan
time: 10:49, flip angle: 9.1, Echo spacing: 8.9
UCT: Siemens Magnetom Skyra 3T; voxel size (1.0×1.0×1.0 [mm] ), slices (160), FoV read (256mm),
slice thickness (1mm), distance factor (50%), TR (2530.0 ms), Base resolution (256), scan time: 6:02,
flip angle: 7.0, Echo spacing: 9.8
Christine Lochner
SU/UCT MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry,
Stellenbosch University, South Africa
Dan J. Stein
SU/UCT MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and
Mental Health, University of Cape Town, South Africa
Garavan
Project Name: Trinity-THC (Addiction_Garavan)
Hugh Garavan, Robert Hester

We examined cognition in chronic cannabis users in comparison to matched (education, age, gender)
healthy controls. We were specifically interested in whether previous reports of diminished error-
related activity were associated with decrements in behavioural measures of error awareness and
learning from error performance.
IRB approval was obtained from Trinity College Dublin IRB.
Funding source: This research was supported by USPHS grant from the National Institute on Drug
Abuse: DA01865-01, Australian Research Council Grant (RH) DP0556602 and Australian National
Health and Medical Research Council Career Development Award 519730 (RH).
3T, MPRAGE, TR=2s, TE=3ms, flip angle=12˚, matrix=256x256x176, voxelsize=0.9mm3

Sinha
Project Name: Addiction_Sinha
IRC:
Rajita Sinha, Sara Blaine

This study enrolled health controls and alcohol dependent treatment seeking men and women to assess
brain response to stress, drug cue and neutral-control exposure during early treatment.
IRB was obtained from Yale Univ School of Medicine
Rajita Sinha received funds from NIH/NIDA:
P50-DA016556, R01-AA013892, UL1-DE019586, PL1-DA024859
Self-report

3T, MPRAGE, TR =2530ms, TE=3.34ms, 1 flip angle=7˚, matrix/FOV = 256x256x176, voxel size =
1x1x1mm3
SCOR:
Rajita Sinha, Sara Blaine

This study enrolled health controls and cocaine dependent treatment seeking men and women to assess
brain response to stress, drug cue and neutral-control exposure during early treatment.
IRB was obtained from Yale Univ School of Medicine
Rajita Sinha received funds from NIH/NIDA:

P50-DA016556, R01-AA013892, UL1-DE019586, PL1-DA024859
Self-report

3T, MPRAGE, TR =2530ms, TE=3.34ms, 1 flip angle=7˚, matrix=256x256x176, voxel size =
1x1x1mm3
HUBIN_KASP
Project Name: HUBIN_KASP
KaSP:
Karolinska Schizophrenia Project (KaSP) is a multidisciplinary research consortium that investigates
the pathophysiology of schizophrenia. KaSP enrolls first-episode mostly drug naïve patients in
Stockholm in a programme involving CSF and blood sampling, structural and functional MR
examinations, molecular PET, cardiovascular measures and extensive clinical characterization
including cognitive function. One major objective is to examine immune-related pathways in
schizophrenia.
The study was approved by the Regional Ethics Committee in Stockholm and conformed to the tenets
of the Declaration of Helsinki. Subjects were included after providing written informed consent after
receiving a complete description of the study. Diagnosis was established based on a structured clinical
interview of the DSM-IV or a consensus diagnostic procedure. Subjects were included from Jan 2011.
The project is ongoing.
KaSP was supported by the Swedish Research Council (K2015-62X-15077-12-3), and by grants from
the Swedish Medical Research Council (SE: 2009-7053; 2013-2838; SC: 523- 2014-3467), the
Swedish Brain Foundation, Åhlén-siftelsen, Svenska Läkaresällskapet, Petrus och Augusta Hedlunds
Stiftelse, Torsten Söderbergs Stiftelse, the AstraZeneca-Karolinska Institutet Joint Research Program
in Translational Science, Söderbergs Königska Stiftelse, Professor Bror Gadelius Minne, Knut och
Alice Wallenbergs stiftelse, Stockholm County Council (ALF and PPG), Centre for Psychiatry
Research, KID-funding from the Karolinska Institutet.
HUBIN:
The HUBIN project has since 1999 investigated patients with schizophrenia spectrum disorder and
control subjects with the aim to add to the understanding of the etiology and pathogenesis of the
disorder. Patients have been recruited from psychiatric clinics in northwestern Stockholm County and
control subjects either among subjects previously participating in biological psychiatric research at the
Karolinska Institutet or drawn from a representative register of the population in Stockholm County.
All participants had given informed consent prior to inclusion in the project. The Ethical Committee of
the Karolinska Hospital, the Stockholm Regional Ethical Committee and the Swedish Data Inspection
Board approved the study. The study was supported by the Swedish Research Council (grant numbers
K2015-62X-15077-12-3), the regional agreement between Karolinska Institutet and Stockholm
County Council, the Karolinska Institutet and the Knut and Alice Wallenberg Foundation.
Self report.
T1-images were acquired using a 3T GE scanner and 3D IR prep fast SPGR sequence with
the following parameters: TR=7.904ms, TE=3.06ms, TI = 450ms, flip angle = 12, 146 sagittal
slices, voxel size = 0.934 x 0.934 x 1.2 mm3, matrix = 256 x 256. FreeSurfer version 5.3 was
used for data processing.
Malt
Project Name: Oslo Malt study (Elvsåshagen T, Bøen E, Malt UF)
The Oslo Malt study is a longitudinal study of brain structure and plasticity in healthy controls and
individuals with bipolar II disorder. The study is conducted at Oslo University Hospital, Oslo,
Norway. The study is funded by the Research Council of Norway (167153/V50, 204966/F20), the
South-Eastern Norway Regional Health Authority, Oslo University Hospital, and research grants from
Mrs. Aslaug Throne-Holst and from the Ebbe Frøland Foundation.
Handedness was based on self report in a clinical interview with one of the study psychiatrists.

Imaging was performed on a 3T Philips Achieva Scanner (Philips Healthcare, Eindhoven, the
Netherlands) using an 8-channel SENSE head coil. The pulse sequence used for volumetric analyses
was a T1-weighted 3D turbo field echo (TFE) sequence (TR/TE = 8.4 ms/2.3 ms, FOV = 256 mm ×
256 mm × 220 mm, 1 mm isotropic resolution, TA = 7 min 40 s). The T1-weighted MR images were
analysed using FreeSurfer version 5.1 (http://surfer.nmr.mgh.harvard.edu/).
MDD_Ilya
Project Name: CODE

The CODE cohort was collected from studies funded by Lundbeck and the German Research
Foundation (WA 1539/4-1, SCHN 1205/3-1, SCHR 443/11-1).
Self-report

MRI data in CODE were acquired with either a 3T Siemens Trio (4 Sites) or 3T Philips Achieva (1
site) scanner. Acquisition parameters for the Siemens scanners were: T1 mprage, voxel size 1 mm x 1
mm x 1 mm; TR=1900 msec; TE=2.52 msec; Sample 1: 192 slices, Sample 2: 176 slices (except 1
site: 192). For the Philips scanner: T1 3D-TFE, voxel size 1 mm x 1 mm x 1 mm; TR=8.3 msec;
TE=3.8 msec; 170 slices. FreeSurfer version 5.3 was used, running on Ubuntu 12.04 LTS (Linux
64bit).
Foxe
Project Name: Cocaine (Addiction_Foxe)
Authors: Hugh Garavan, John Foxe
These projects studied cognitive control and reward processing in current and abstinent cocaine users.
HG & JF received funds from NIDA: R01-DA014100
The research received ethics approval from IRB boards.
Self-report

3T, MPRAGE, TR=11.6ms, TE=4.9ms, flip angle = 8°, matrix=256×256x172, voxel size =
1.2×1.2x1.2 mm3
Christoph
Project Name: S:t Göran Bipolar project (SBP)

The S:t Göran Bipolar project (SBP) was established by Mikael Landén in 2005. Patients are currently
recruited from Affektivt centrum, Norra Stockholms psykiatri and from 2009 also from
Bipolärmottagningen in Gothenburg. Patients diagnosed with bipolar disorder are meticulously
phenotyped and followed over time. The study participants are investigated using diagnostic,
neuropsychological, neurological, imaging, genetic and biochemical approaches. This enables the
identification of clinically relevant subgroups and markers and provides unique possibilities to study
disease mechanisms. A long term aim is to identify factors and markers that are predictive of relapse,
treatment response, side effects, cognitive and psychosocial functioning and quality of life for
individuals suffering from bipolar syndromes.
According to the Declaration of Helsinki, all study subjects consented orally and in writing to
participate in the study. The study was approved by the Ethics committee of the Karolinska Institutet,
Stockholm, Sweden.
The SBP is supported by grants from the Swedish Medical Research Council (K2014-62X-14647-12-
51, K2010-61P-21568-01-4, and K2013-61X-08276-26-4), the Swedish foundation for Strategic
Research (KF10-0039), the Swedish Brain foundation (FO2016-0176), and the Swedish Federal
Government under the LUA/ALF agreement (ALFGBG-426721).
We thank the patients participating in this study. We also wish to thank the staff at the St. Göran
bipolar affective disorder unit, including study nurses coordinator Lena Lundberg and Benita Gezelius,
as well as data manager Mathias Kardell. We also thank Marie Tegnér and Yords Österman who
performed the MR scanning.
- Edinburgh Handedness Inventory (not provided)

MRI scans were acquired at the MR Research Center, Karolinska University Hospital, Stockholm.
Coronal 3D T1 weighted images were acquired with a spoiled gradient echo recall sequence (3D-
SPGR, TR=21.0 ms, TE=6 ms, FOV=18 cm, flip angle=30˚, acquisition matrix=256×256×128, voxel
size: 0.7x0.7x1.8mm3) using a 1.5-Tesla MRI medical scanner (General Electric Signa Excite 1.5T)
equipped with an eight channel head coil.
Images were processed using Freesurfer 5.1.

NESDA
Project Name: NESDA

The Netherlands Study of Depression and Anxiety (NESDA) is a prospective cohort study with the
main aim to examine the long-term prognosis and co-morbidity of anxiety and depression in order to
improve quality of care and prevent chronicity. The infrastructure for the NESDA study
(http://www.nesda.nl) is funded through the Geestkracht program of the Netherlands Organisation for
Health Research and Development (Zon-Mw, grant no 10-000-1002) and is supported by participating
universities and mental health care organizations (VU University Medical Center, GGZ inGeest,
Arkin, Leiden University Medical Center, GGZ Rivierduinen, University Medical Center Groningen,
Lentis, GGZ Friesland, GGZ Drenthe, Scientific Institute for Quality of Healthcare (IQ healthcare),
Netherlands Institute for Health Services Research (NIVEL) and Netherlands Institute of Mental
Health and Addiction (Trimbos Institute).
Within the context of NESDA a nested study was performed in patients diagnosed with alcohol
dependence, also including a healthy control group. This nested study was supported by a ZonMW
grant no. 31160004 from the Netherlands Organization for Scientific Research (NWO).
Publications that came out of this nested study, and used the structural scans for coregistration
purposes with functional MRI data:
1. Sjoerds, Z, Van den Brink, W, Beekman, ATF, Penninx, BWJH, Veltman, DJ (2013). Response
inhibition in alcohol dependent patients and patients with depression/anxiety: an fMRI study.
Psychological Medicine 44(8): 1713-1725.
2. Sjoerds, Z, De Wit, S, Van den Brink, W, Robbins, TW, Beekman, ATF, Penninx, BWJH, Veltman,
DJ (2013). Behavioral and neuroimaging evidence for a bias to the habit system in alcohol dependent
patients. Translational Psychiatry 3: e337.
3. Sjoerds, Z, Van den Brink, W, Beekman, ATF, Penninx, BWJH, Veltman, DJ (2014). Cue reactivity
is associated with duration and severity of alcohol dependence: an fMRI study. PLOS One
9(1):e84560.
4. Sjoerds Z, Stufflebeam SM, Veltman DJ, Van den brink W, Penninx BWJH, Douw L (2017).
Progressive loss of global and local brain network efficiency in alcohol dependence. Addiction
Biology. Mar;22(2):523-534

Handedness was assessed with the Dutch version of the self-report Hand Preference Questionnaire
(van Strien 1992).

Magnetic Resonance Imaging (MRI) data were obtained using 3T Phillips MRI scanners (Phillips
Healthcare, Best, The Netherlands) located at the three participating centers, equipped with a SENSE
8-channel (LUMC and UMCG) and a SENSE 6-channel (AMC) receiver head coil. Three-dimensional
T1-weighted images were collected using a gradient echo sequence (TR=9ms, TE=3.5ms, matrix size:
256x256, voxel size: 1x1x1mm, 170 slices). FreeSurfer version 5.3 was used.
02_Heuvel_1.5T
Project Name: OCD_VUmc 1.5T

The 1.5 T MRI data are collected in the context of two independent fMRI studies in OCD. The first
study (PhD project of Odile van den Heuvel) studied cognitive paradigms in OCD, in comparison with
panic disorder, hypochondriasis and healthy controls, both at baseline (ref 2-3) and after naturalistic
follow-up (ref 4). The second study (PhD project of Peter Remijnse) studied cognitive paradigms in
OCD, in comparison with depressive patients and healthy controls, both at baseline (ref 6-7-8) and
after naturalistic follow-up (ref 5). The structural MRI scans have been pooled to perform a VBM
study in the combined samples of OCD and controls (ref 1).
Supported by the Dutch Organization for Scientific Research (NWO) (grants 912-02-050, 907-00-012,
940-37-018, and 916.86.038).
Publications that came out of these 2 OCD studies:

1. van den Heuvel OA, Remijnse PL, Mataix-Cols D, Vrenken H, Groenewegen HJ, Uylings HB, van
Balkom AJ, Veltman DJ. The major symptom dimensions of obsessive-compulsive disorder are
mediated by partially distinct neural systems. Brain. 2009 Apr;132(Pt 4):853-68.
2. van den Heuvel OA, Veltman DJ, Groenewegen HJ, Witter MP, Merkelbach J, Cath DC, van
Balkom AJ, van Oppen P, van Dyck R. Disorder-specific neuroanatomical correlates of attentional
bias in obsessive-compulsive disorder, panic disorder, and hypochondriasis. Arch Gen Psychiatry.
2005 Aug;62(8):922-33.
3. van den Heuvel OA, Veltman DJ, Groenewegen HJ, Cath DC, van Balkom AJ, van Hartskamp J,
Barkhof F, van Dyck R. Frontal-striatal dysfunction during planning in obsessive-compulsive disorder.
Arch Gen Psychiatry. 2005 Mar;62(3):301-9.
4. van den Heuvel OA, Mataix-Cols D, Zwitser G, Cath DC, van der Werf YD, Groenewegen HJ, van
Balkom AJ, Veltman DJ. Common limbic and frontal-striatal disturbances in patients with obsessive
compulsive disorder, panic disorder and hypochondriasis. Psychol Med. 2011 Nov;41(11):2399-410.
5. Vriend C, de Wit SJ, Remijnse PL, van Balkom AJ, Veltman DJ, van den Heuvel OA. Switch the
itch: a naturalistic follow-up study on the neural correlates of cognitive flexibility in obsessive-
compulsive disorder. Psychiatry Res. 2013 Jul 30;213(1):31-8.
6. Remijnse PL, van den Heuvel OA, Nielen MM, Vriend C, Hendriks GJ, Hoogendijk WJ, Uylings
HB, Veltman DJ. Cognitive inflexibility in obsessive-compulsive disorder and major depression is
associated with distinct neural correlates. PLoS One. 2013 Apr 24;8(4):e59600.
7. Remijnse PL, Nielen MM, van Balkom AJ, Hendriks GJ, Hoogendijk WJ, Uylings HB, Veltman
DJ. Differential frontal-striatal and paralimbic activity during reversal learning in major depressive
disorder and obsessive-compulsive disorder. Psychol Med. 2009 Sep;39(9):1503-18.
8. Remijnse PL, Nielen MM, van Balkom AJ, Cath DC, van Oppen P, Uylings HB, Veltman DJ.
Reduced orbitofrontal-striatal activity on a reversal learning task in obsessive-compulsive disorder.
Arch Gen Psychiatry. 2006 Nov;63(11):1225-36.

self report

MRI data were acquired with a 1.5 Tesla Siemens Sonata scanner. The parameters used were matrix
256x160, 160 slices and, voxel size 1x1x1.5 mm. Images were processed with FreeSurfer version 5.3.
04_Mataix_Cols
Project Name: OCD_Mataix-Cols OCD studies

These structural scans come from a series of studies conducted at King’s College London and funded
by the Wellcome Trust (Mary L Phillips, PI) and a pump priming grant from the South London and
Maudsley Trust, London (project grant no. 064846; David Mataix-Cols PI). The broad aims of these
studies were to examine the neuropsychological and neural correlates of various symptom dimensions
of obsessive-compulsive disorder (OCD) and to identify neural predictors of treatment outcome in this
disorder. We would like to thank Prof Mary L Phillips, Dr Natalia Lawrence and Sarah Wooderson for
their contribution to the project (obtaining funding, data collection) and to all persons who kindly
participated in this research.
Self report

MRI data were acquired with a 1.5 Tesla GE Signa scanner. The parameters used were matrix
256x256, 124 slices, 0.94x0.94x1.5. Images were processed with FreeSurfer version 5.3.
SHIP-TREND-0
Project Name: SHIP-TREND

SHIP-TREND is a general population based cohort which is comprised of adult German residents and
which is independent of the SHIP cohort.
A separate stratified random sample of 8,016 adults aged 20 to 79 years was drawn for SHIP-TREND.
The target sample size was chosen to achieve a final sample size similar to that of SHIP-0. The
baseline examinations (SHIP-TREND-0) were performed from June 2009 until October 2012
(n=4422).
The SHIP-TREND study was approved by the ethics committee of the University of Greifswald.
Written informed consent was obtained from all participants.
SHIP is part of the Community Medicine Research net of the University of Greifswald, Germany,
which is funded by the Federal Ministry of Education and Research (grants no. 01ZZ9603, 01ZZ0103,
and 01ZZ0403), the Ministry of Cultural Affairs and the Social Ministry of the Federal State of
Mecklenburg-West Pomerania. MRI scans in SHIP-TREND have been supported by a joint grant from
Siemens Healthineers, Erlangen, Germany and the Federal State of Mecklenburg-West Pomerania.
Self-report

Subjects from SHIP-TREND-0 were asked to participate in a whole-body magnetic resonance imaging
(MRI) assessment. After exclusion of subjects who refused participation or who fulfilled exclusion
criteria for MRI (e.g. cardiac pacemaker) 2154 subjects from SHIP-TREND-0 underwent the MRI
scanning.
Image Acquisition: All images were obtained using the same 1.5 T Siemens MRI scanner (Magnetom
Avanto, Siemens Medical Systems, Erlangen, Germany) with a T1-weighted magnetization prepared
rapid acquisition gradient echo (MPRAGE) sequence and following parameters: axial plane, TR=1900
ms, TE=3.4 ms and Flip angle=15° and an original resolution of 1.0 x 1.0 x 1.0mm3.
Hans Jörgen Grabe

Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Germany; German
Center for Neurodegenerative Diseases (DZNE), Rostock/ Greifswald, Germany
Katharina Wittfeld
German Center for Neurodegenerative Diseases (DZNE), Rostock/ Greifswald, Germany
Henry Völzke
Institute for Community Medicine, University Medicine Greifswald, Germany; DZHK (German
Centre for Cardiovascular Research), partner site Greifswald, Germany; German Centre for Diabetes
Research (DZD), Site Greifswald, Germany
Robin Bülow
Department of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald,
Greifswald, Germany
Momenan
Project Name: NIAAA (Addiction_NIAAA)
Reza Momenan

The data in this study are provided from an omnibus neuroimaging assessment protocol and a
functional neuroanatomy of motivation and emotion in Alcoholics and Non-Alcoholics protocol.
Both protocols are IRB approved. Participants enrolled in both protocols are consented.
Data collection by RM was supported by the Intramural Clinical and Biological Research (DICBR)
Program of the National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of
Health.
Self-report and Edinburgh Handedness Inventory were used to determine the handedness. Individuals
with positive scores of the EHI were considered Right Handed.

3T, MPRAGE , TR=4.5-7.8 ms, TE=2.2-3.1ms, flip angle =6˚, voxelsize=0.9x0.9 x1-1.5mm3
4. NIAAA, Contibutors
Reza Momenan, Ph.D., Michael Kerich, B.S.

Clinical NeuroImaging Research Core, National Institute on Alcohol Abuse and Alcoholism, National
Institutes of Health
VanHolst
Project Name: ADPG study
Anneke E. Goudriaan, Ruth J. van Holst

Similarities and differences in between alcohol dependence and gambling addiction were assessed
with fMRI. AG & RvH received funing for the ADPG study from ZonMW grant no.91676084 from
the Netherlands Organization for Scientific Research (NWO).
Self-report

3T, Gradient Echo, TR=9ms TE=4.20ms, flip angle 8°, matrix=256×256x170, voxel size=1×1x1mm3
IRB approval was obtained
02_Heuvel_3T
Project Name: OCD_VUmc 3T

The data have been collected in the context of an fMRI study in unmedicated adult OCD patients, their
unaffected siblings and healthy controls at baseline during cognitive tasks (ref 1-2-3), pre- and post
single-session rTMS (ref 4) and in a subsample also after naturalistic follow-up (work in progress).
We also used the DTI data to perform a comparison between OCD, siblings and controls (ref 5).
Supported in part by the Netherlands Society for Scientific Research (NWO-ZonMw VENI grant
916.86.036 to Dr. van den Heuvel; NWO-ZonMw AGIKO stipend 920-03-542 to Dr. de Vries), and a
NARSAD Young Investigators Award to Dr. van den Heuvel, Amsterdam Brain Imaging Platform to
Dr. van den Heuvel, the Netherlands Brain Foundation (2010(1)-50 to Dr. van den Heuvel).
Publications related to the studies:

1. de Wit SJ, de Vries FE, van der Werf YD, Cath DC, Heslenfeld DJ, Veltman EM, van Balkom AJ,
Veltman DJ, van den Heuvel OA. Presupplementary motor area hyperactivity during response
inhibition: a candidate endophenotype of obsessive-compulsive disorder. Am J Psychiatry. 2012
Oct;169(10):1100-8.
2. de Vries FE, de Wit SJ, Cath DC, van der Werf YD, van der Borden V, van Rossum TB, van
Balkom AJ, van der Wee NJ, Veltman DJ, van den Heuvel OA. Compensatory frontoparietal activity
during working memory: an endophenotype of obsessive-compulsive disorder. Biol Psychiatry. 2014
Dec 1;76(11):878-87.
3. van Velzen LS, de Wit SJ, Ćurĉić-Blake B, Cath DC, de Vries FE, Veltman DJ, van der Werf YD,
van den Heuvel OA. Altered inhibition-related frontolimbic connectivity in obsessive-compulsive
disorder. Hum Brain Mapp. 2015 Oct;36(10):4064-75.
4. de Wit SJ, van der Werf YD, Mataix-Cols D, Trujillo JP, van Oppen P, Veltman DJ, van den
Heuvel OA. Emotion regulation before and after transcranial magnetic stimulation in obsessive
compulsive disorder. Psychol Med. 2015 Oct;45(14):3059-73.
5. Fan S, van den Heuvel OA, Cath DC, van der Werf YD, de Wit SJ, de Vries FE, Veltman DJ,
Pouwels PJ. Mild White Matter Changes in Un-medicated Obsessive-Compulsive Disorder Patients
and Their Unaffected Siblings. Front Neurosci. 2016 Jan 11;9:495.
Edinburgh handedness inventory

MRI data were acquired with a 3 Tesla GE Signa HDxt scanner. The parameters used matrix 256x256,
172 slices and, voxel size 1x0.977x0.977mm. Images were processed with FreeSurfer version 5.3.
01_Cheng_3T
Project Name: Cheng Yuqi (OCD_Cheng_3T)

The database was established in Kunming in 2010. This resource was approved by the ethics
committee of the First Affiliated Hospital of Kunming Medical University. This study was supported
by grants from National Natural Science Foundation of China (NSFC) (81101005,), the Ministry of
Science and Technology of Yunnan Province(2012FB158), the Funding of Yunnan Provincial Health
Science and Technology Plan (2014NS171, 2014NS172), the united founding of Yunnan
Administration of Science & Technology and Kunming Medical College(2011FB167).
Self report confirmed by Edinburgh Handedness Inventory
MRI data were acquired with a 3 Tesla Philips Achieva scanner. The parameters used were matrix
matrix 228 x 228, 230 slices and, voxel size 1.1 x 1.1 x 0.6 mm³. Images were processed with
FreeSurfer version 5.3.
UMCG_sample_groenewold
Project Name: DIP GRONINGEN

DIP was conducted in Groningen, the Netherlands between 2012 and 2014. Data collection for DIP, as
contributed to ENIGMA projects, was funded by the Gratama Foundation, the Netherlands. The
Medical Ethical Committee of the University Medical Center Groningen approved of the DIP study.
Self-report

MRI data in DIP were acquired with a 3 Tesla Philips Intera scanner (Best, the Netherlands). A 3D
gradient-echo T1-weighted sequence was acquired (170 slices; TR=9ms; TE=3.6ms; matrix=256x231;
voxel size=1.0x1.0x1.0mm; scan duration=4:11min.) FreeSurfer version 5.3 was used for processing.
Sjoerds
Project Name: NESDA-AD (Addiction_NESDA-AD)
Zsuzsika Sjoerds & Dick J. Veltman

In this study we examined the neural correlates of cognitive control and habit formation in alcohol
dependent patients compared with healthy controls.
ZS & DV received funding for the NESDA-AD study from ZonMW grant no. 31160004 from the
Netherlands Organization for Scientific Research (NWO).
The VU University Medical Center Ethical Review Board approved this study, and written informed
consent according to the declaration of Helsinki was obtained from all participants prior to study.
The Dutch questionnaire for handedness (Van Strien, 1992).

Van Strien, J.W. (1992). Classificatie van links- en rechtshandige proefpersonen. Nederlands
Tijdschrift voor de Psychologie en Haar Grensgebieden, 47, 88-92.

3T, Gradient Echo, TR=9ms, TE 3.6 ms, flip angle=8˚, matrix= 256x231x170, voxel size=1x1x1mm3
Schmaal
Dataset Name: Addiction_TrIp
Project Name: TrIP study
Lianne Schmaal, Dick Veltman

The main aim of the neuroimaging substudies of the TrIP study was to identify neurobiological
mechanisms underlying a single dose administration of the modafinil and N-acetylcysteine in alcohol
and substance use dependent individuals.
LS & DV received funding for the TrIP study from ZonMW grant no. 31160003 from the Netherlands
Organization for Scientific Research (NWO).
Self-report

3T, Gradient Echo, TR=9ms, TE=3.5ms, flip angle=8˚, matrix=256x256x170, voxel size=1x1x1mm3
Affiliations Lianne:
1 Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Australia
2 Centre for Youth Mental Health, The University of Melbourne, Melbourne, Australia.
3 Department of Psychiatry, Amsterdam Neuroscience, VU University Medical Center, Amsterdam,
The Netherlands
OLDERS
Project Name: Gene-Brain-Behavior (GBB) Project (GBB_OLDERS)

The Gene-Brain-Behavior（GBB）Project was initiated in Southwest University in 2011, which is an
ongoing project exploring the associations among individual differences in brain structure and
function, creativity, and mental health. The project was approved by the Southwest University Brain
Imaging Center Institutional Review Board, and written informed consent was obtained from each
subject. Participants received payment depending on time and tasks completed.This research was
supported by the National Natural Science Foundation of China (31271087; 31470981; 31571137;
31500885), National Outstanding young people plan, the Program for the Top Young Talents by
Chongqing, the Fundamental Research Funds for the Central Universities

Part of subjects were confirmed by Edinburgh Handedness Inventory, and the rest were confirmed by
self report.

Imaging data were collected using an 8-channel head coil on a Siemens 3T Trio scanner (Siemens
Medical Systems, Erlangen, Germany) at the Brain Imaging Center, Southwest University. The same
scanner and sequences were used at both time points. High-resolution, three-dimensional T1-weighted
structural images were obtained using a Magnetization Prepared Rapid Acquisition Gradient-echo
(MPRAGE) sequence (TR/TE =1900 ms/2.52 ms, FA = 9 degrees, FOV= 256 × 256 mm2; slices =
176; thickness = 1.0 mm; voxel size = 1×1×1 mm3). FreeSurfer version 5.3 was used
Jiang Qiu[[email protected]]; Qun-lin Chen; Xing-xing Zhu

School of Psychology, Southwest University; Key Laboratory of Cognition and Personality, Ministry
of Education, Chongqing, China
SHIP-2
Project Name: Study of Health in Pomerania (SHIP)

SHIP is a general population based sample. The target population was comprised of adult German
residents (20-79 years in 1997-2001) in northeastern Germany living in 3 cities and 29 communities,
with a total population of 212,157. The net sample comprised 6,267 eligible subjects, of which 4,308
Caucasian subjects participated in SHIP-0. Follow-up examination (SHIP-1) was conducted 5 years
after baseline (2002-2006) and included 3300 subjects. From 2008 to 2012 the third phase of data
collection (SHIP-2, N=2333) was carried out.
The SHIP study was approved by the ethics committee of the University of Greifswald. Written
informed consent was obtained from all participants.
SHIP is part of the Community Medicine Research net of the University of Greifswald, Germany,
which is funded by the Federal Ministry of Education and Research (grants no. 01ZZ9603, 01ZZ0103,
and 01ZZ0403), the Ministry of Cultural Affairs and the Social Ministry of the Federal State of
Mecklenburg-West Pomerania. MRI scans in SHIP have been supported by a joint grant from Siemens
Healthineers, Erlangen, Germany and the Federal State of Mecklenburg-West Pomerania.
Self-report

Subjects from SHIP-2 were asked to participate in a whole-body magnetic resonance imaging (MRI)
assessment. After exclusion of subjects who refused participation or who fulfilled exclusion criteria
for MRI (e.g. cardiac pacemaker) 1163 subjects from SHIP-2 underwent the MRI scanning.
Image Acquisition: All images were obtained using the same 1.5 T Siemens MRI scanner (Magnetom
Avanto, Siemens Medical Systems, Erlangen, Germany) with a T1-weighted magnetization prepared
rapid acquisition gradient echo (MPRAGE) sequence and following parameters: axial plane, TR=1900
ms, TE=3.4 ms and Flip angle=15° and an original resolution of 1.0 x 1.0 x 1.0mm3.

NicolaOATS
Project Name: OATS

Participants in the Older Australian Twins Study (OATS) were aged 65 years and over, and were
recruited from the Twins Research Australia and through a recruitment drive. Inclusion criteria
included an ability to consent, a co-twin who consented to participate, completion of some education
in English and at least a low average IQ. Exclusion criteria included inadequate English to complete
the assessment and/or a current diagnosis of an acute psychosis. More details can be found in Sachdev
et al. (2009).
OATS was approved by the appropriate ethics committees of the Twins Research Australia, University
of New South Wales, University of Melbourne, Queensland Institute of Medical Research and the
South Eastern Sydney and Illawarra Area Health Service. All participants provided written informed
consent.
We would like to acknowledge and thank the OATS participants, their supporters and the OATS
Research Team. OATS is supported by a National Health and Medical Research Council
(NHMRC)/Australian Research Council Strategic Award (Grant 401162) and the NHMRC Project
Grant (1045325). OATS was facilitated through access to the Australian Twin Registry, which is
funded by the NHMRC Enabling Grant 310667.
Self reported.

Participants were invited to undergo a brain MRI scan. A total of 414 individuals underwent a MRI
brain scan after excluding participants due to contraindications.
MRI data were obtained on three 1.5 Tesla scanners and a 3 Tesla scanner owing to the multi-site
nature of this study. Siemens Magnetom Avanto and Sonata scanners (Siemens Medical Solutions,
Malvern PA, USA) with similar years of manufacture and upgrade were used in centres 2 and 3,
respectively. In centre 1, a 1.5 T Philips Gyroscan scanner (Philips Medical Systems, Best,
Netherlands) was used initially, followed by a 3 Tesla Philips Achieva Quasar Dual scanner. See (Wen
et al for details) 3D T1-weighted volumetric sequence was performed using a similar protocol for the
1.5 Tesla scanners in the three centres with in-plane resolution = 1×1 mm, slice thickness = 1.5 mm,
slice number =144, TR (Repetition time) = 1530 ms, TE (Echo time) = 3.24 ms, TI (Inversion time) =
780 ms, and flip angle = 8. The acquisition parameters for the 3 Tesla Philips scanner in centre 1 were:
TR/TE = 6.39/2.9 ms, in-plane resolution = 1×1 mm, slice thickness = 1 mm, slice number =190,
resulting isotropic voxels of 1×1×1 mm3. Two 3D T1-weighted scans were acquired for each
participant for an increased signal-to-noise ratio (SNR).
FreeSurfer version 5.3.0 was used.
References
Sachdev PS, Lammel A, Trollor JN, Lee T, Wright MJ, Ames D, Wen W, Martin NG, Brodaty H,
Schofield PR; OATS research team. (2009). A Comprehensive Neuropsychiatric Study of Elderly
Twins:The Older Australian Twins Study.Twin Res Hum Genet 12 (6) 573-582
Perminder S Sachdev
Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Australia
Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, Australia
Wei Wen
Henry Brodaty
Dementia Collaborative Research Centre ØC Assessment and Better Care, University of New South
Wales, Sydney, Australia
Nicola J Armstrong
Mathematics and Statistics, Murdoch University, Perth Australia

Margaret J Wright
David Ames
National Ageing Research Institute, Melbourne, Australia
Academic Unit for Psychiatry of Old Age, University of Melbourne, Melbourne, Australia
NicolaMAS
Project Name: MAS

Sydney Memory and Ageing Study (Sydney MAS) is a community-based longitudinal study of older
adults aged 70-90 years living in Sydney, Australia. Briefly, 1037 non-demented community-dwelling
participants were randomly recruited from the compulsory electoral rolls of two regions in Sydney,
Australia. Inclusion criteria included sufficient English to complete the assessment. Exclusion criteria
included psychotic symptoms or inability to complete the assessment due to a medical or
psychological condition. More details can be found in Sachdev et al (2010).
Sydney MAS was approved by the Human Research Ethics Committees of the University of New
South Wales and the South Eastern Sydney Local Health District. All participants gave written
informed consent.
We would like to acknowledge and thank the Sydney MAS participants, their supporters and the
Sydney MAS Research Team. Sydney MAS is supported by the National Health and Medical
Research Council (NHMRC) Program Grants (350833, 56896, 109308).
Self-reported.

Participants were invited to undergo a brain MRI scan. A total of 542 individuals underwent a MRI
brain scan after excluding participants due to contraindications. Participants were scanned using either
a Philips 3T Intera Quasar scanner (Philips Medical Systems, Netherlands) or a Philips 3T Achieva
Quasar Dual scanner. For further details see Jiang et al. 2013. Acquisition parameters for T1-
weighted structural MRI scans were the same for both scanners: TR = 6.39 ms, TE = 2.9 ms, flip angle
= 8°, matrix size = 256x256, FOV = 256x256x190, and slice thickness = 1 mm with no gap between;
yielding 1x1x1 mm3 isotropic voxels. FreeSurfer version 5.3.0 was used.
References
Jiang J, Sachdev P, Lipnicki DM, Zhang H, Liu T, et al. (2013) A longitudinal study of brain atrophy
over two years in community-dwelling older individuals. NeuroImage
10.1016/j.neuroimage.2013.08.022.
Sachdev, P.S., Brodaty, H., Reppermund, S., Kochan, N.A., Trollor, J.N., Draper, B., Slavin, M.J.,
Crawford, J., Kang, K., Broe, G.A., Mather, K.A., Lux, O.; Memory and Ageing Study Team. (2010).
The Sydney Memory and Ageing Study (MAS): methodology and baseline medical and
neuropsychiatric characteristics of an elderly epidemiological non-demented cohort of Australians
aged 70-90 years. Int Psychogeriatr Dec;22(8):1248-64.
Perminder S Sachdev

Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, Australia
Wei Wen
Henry Brodaty

Dementia Collaborative Research Centre ØC Assessment and Better Care, University of New South
Wales, Sydney, Australia
Nicola J Armstrong
Mathematics and Statistics, Murdoch University, Perth Australia

LBC1936
Project Name: Lothian Birth Cohort of 1936

The Lothian Birth Cohort of 1936 (LBC1936) were born in 1936, lived independently in the Lothian
region of Scotland, and most had participated in the Scottish Mental Survey of 1947. They were
assessed on cognitive and medical measures at age 70 years (n=1,091), and again with brain imaging
traits at 73 years of age (n=866). (Deary et al, 2007, Wardlaw et al 2011). The study was approved by
the Lothian (REC 07/MRE00/58) and Scottish Multicentre (MREC/01/0/56) Research Ethics
Committees and all subjects give written informed consent. Data collection was supported by the
Disconnected Mind project, funded by Age UK. J.M.W. is partly funded by the Scottish Funding
Council as part of the SINAPSE Collaboration. The work was undertaken by The University of
Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology, part of the cross-council
Lifelong Health and Wellbeing Initiative (MR/K026992/1). Funding from the Biotechnology and
Biological Sciences Research Council (BBSRC) and MRC is gratefully acknowledged. We thank the
study participants. We also thank Catherine Murray for recruitment of the participants and the
radiographers and other staff at the Brain Research Imaging Centre.
Refs:
Deary, I.J., Gow, A.J., Taylor, M.D., Corley, J., Brett, C., Wilson, V., Campbell, H., Whalley, L.J.,
Visscher, P.M., Porteous, D.J. Starr, J.M.. The Lothian Birth Cohort 1936: a study to examine
influences on cognitive ageing from age 11 to age 70 and beyond. BMC Geriatr 7, 28 (2007). PMID
18053258
Wardlaw, J. M., Bastin, M. E., Valdes Hernandez, M. C., Munoz maniega, S., Royle, N. A., Morris,
Z., Claysden, J. D., Sandeman, E. M., Eadie, E., Murray, C., Starr, J. M., & Deary, I. J. (2011). Brain
ageing, cognition in youth and old age, and vascular disease in the Lothian Birth Cohort 1936:
rationale, design and methodology of the imaging protocol. International Journal of Stroke, 6, 547-
559.

Writing hand.
LBC1936 brain MRI data were acquired at the University of Edinburgh’s Brain Research Imaging
Centre using a GE Signa Horizon HDx 1.5T clinical scanner, with a self-shielding gradient set (33
mT/m maximum gradient strength), and a manufacturer-supplied eight-channel phased-array head
coil. T1-, T2-, T2* and FLAIR-weighted structural scans were acquired for each participant. Each T1-
weighted scan was acquired in the coronal plane using a three-dimensional inversion-recovery-
prepared fast-spoiled gradient-echo sequence. Volumes comprised 160 1.3 mm thick slices with a
resolution of 1 mm2 and a 256 mm2 field of view, covering the complete intracranial contents. Cortical
parcellation was performed using FreeSurfer 5.1, and output was visually quality checked and
manually edited.
Ref:
Wardlaw JM, Bastin ME, Valdes Hernandez MC, et al. Brain aging, cognition in youth and old age
and vascular disease in the Lothian Birth Cohort 1936: rationale, design and methodology of the
imaging protocol. International journal of stroke : official journal of the International Stroke Society
2011;6:547-559.
FIDMAG
Healthy individuals were recruited from non-medical staff working in the hospital, their relatives and
acquaintances, plus independent sources in the community, in order to be included in healthy control
groups of several studies of specific disorders such as schizophrenia or ADHD (see some references
below).
Participants were questioned following a structured format and were excluded if they reported a
history of mental illness, history of major mental illness in a first-degree relative and/or treatment with
psychotropic medication apart from non-habitual use of anxiolytics/hypnotics.
Written informed consent was obtained from all participants. All studies were approved by the local
research ethics committee.
Self report.
MRI data were acquired with the same 1.5-T GE Signa scanner using the same T1-weighted sequence
with the following parameters: 180 axial slices, 1 mm slice thickness with no gap, 512×512 matrix
size, 0.5×0.5×1 mm3 voxel resolution, 4 ms echo time, 2000 ms repetition time, 15° flip angle.
References
● Landin-Romero R, Amann BL, Sarro S, et al. Midline Brain Abnormalities Across Psychotic
and Mood Disorders. Schizophr Bull. 2016;42(1):229-238.
● Landin-Romero R, Sarro S, Fernandez-Corcuera P, et al. Prevalence of cavum vergae in
psychosis and mood spectrum disorders. J Affect Disord. 2015;186:53-57.
● Moreno-Alcazar A, Ramos-Quiroga JA, Radua J, et al. Brain abnormalities in adults with
Attention Deficit Hyperactivity Disorder revealed by voxel-based morphometry. Psychiatry
Res. 2016;254:41-47.
● Radua J, Canales-Rodriguez EJ, Pomarol-Clotet E, Salvador R. Validity of modulation and
optimal settings for advanced voxel-based morphometry. Neuroimage. 2014;86:81-90.
● Vicens V, Radua J, Salvador R, et al. Structural and functional brain changes in delusional
disorder. Br J Psychiatry. 2016;208(2):153-159.
ACPU
Project Name: ADHD_ACPU

Typically developing male control participants were recruited through local schools and had no known
current or previous psychiatric or neurological conditions. All participants/parents gave written
informed consent. Approval was obtained from the Human Research Ethics Committee at the Royal
Children’s Hospital.
Edinburgh Handedness Questionnaire or a subtest of the Scored Developmental Neurological
Examination
Neuroimaging data were collected from a single-site on a research-dedicated 3-Tesla Siemens TIM
Trio MRI scanner (Siemens, Erlangen, Germany) at the Murdoch Childrens Research Institute, The
Royal Children’s Hospital, Melbourne. Using a 32-channel head coil a structural T1-weighted image
acquire: TR = 1900 ms, flip angle 90°, FoV = 208*230, 232*256*192 matrix, slice thickness = 1.0
mm and inplane pixels = 0.9 *0.9 mm2. Images were processed with FreeSurfer version 5.3.0.
NICAP
Project Name: ADHD_NICAP

This sample of typically developing children were recruited as a part of the Neuroimaging of the
Children’s Attention Project (see Silk, et al. (2016) for a detailed protocol). The NICAP cohort is a
community-based sample aged 9-11years recruited from 43 socio-economically diverse primary
schools across Melbourne, Australia. The study was funded by the National Medical Health and
Research Council of Australia (NHMRC; project grant #1065895). The Human Research Ethics
Committee of the Royal Children's Hospital, Melbourne approved present study procedures (#34071),
and parents/guardians of all participants provided written informed consent.
Self report.
Neuroimaging data were collected from a single-site on a research-dedicated 3-Tesla Siemens TIM
Trio MRI scanner (Siemens, Erlangen, Germany) at the Murdoch Childrens Research Institute, The
Royal Children’s Hospital, Melbourne. Using a 32-channel head coil, participants undertook a 45min
neuroimaging protocol which included a structural T1-weighted image acquired using a modified
three-dimensional multi-echo magnetization-prepared rapid gradient-echo imaging (MEMPRAGE; TR
= 2530ms, TEs = 1.77, 3.51, 5.32, 7.20 ms, flip angle 70, voxel size = 0.9mm3) incorporating
navigator based prospective motion correction (MoCo). Images were processed with FreeSurfer
version 5.3.0.
ADHD_Dundee
Dataset Name: ADHD_Dundee
Project Name: iBOCA
David Coghill, Blair Johnston, Douglas Steele

This study investigated structural and functional brain alterations in young people aged 10 - 18 years
with ADHD as compared to healthy controls. The main aims of the study were to investigate
dopamine functioning as look for predictors of response to treatment. The study was funded by an
Anonymous Trust and received approval from the local NHS Ethics Committee.
Self-report.

The scans were collected at a single site (Ninewells Hospital Dundee) on a 3T Siemens Magnetom
TrioTim syngo scanner, T1-weighted MP-RAGE anatomical scan with the following parameters: TR
= 1900 ms, TE = 2.64 ms, flip angle = 9°, FOV = 200 mm, matrix = 256 x 256, 176 slices, voxel size
0.8x0.8x1 mm, slice thickness 1 mm
ADHD WUE
Dataset Name: ADHD_Wuerzburg
Project Name: ADHDEmotion

Annette Conzelmann, Paul Pauli, Georg Ziegler, Ramona Baur, Andreas Reif, Kathrin Zierhut, Klaus-
Peter-Lesch

This study investigated structural and functional brain alterations in adults with ADHD as compared to
healthy controls. It was funded by the DFG and received approval from the local Ethics Committee.
Self-report.

1,5T Siemens Magnetom Avanto; MPRAGE; TR = 2250 ms; TE = 3.93 ms; flip angle 8˚ ;slices 160;
FoV 256; voxel size=1x1x1mm3 . Freesurfer 5.3 was used.
GOBS
Dataset Name: GOBS
Project Name: Genetics of Brain Structure

GOBS subjects were recruited from two preceding studies: the San Antonio Family Heart Study and
the San Antonio Family Gallbladder Study. GOBS is a family study comprising 1,443 individuals with
MRI data (836 females), aged between 18 and 85 years at the time of scanning. All GOBS subjects are
Mexican Americans and belong to pedigrees of varying sizes (the largest pedigree has 143 members).
Inapplicable.

All images were acquired on a Siemens 3 T TIM Treo MR scanner and a high-resolution phase array
head coil housed in the Research Imaging Institute, UTHSCSA. Images for gray matter analyses
included seven high-resolution T1-weighted 3D turbo-flash sequences with an adiabatic inversion
contrast pulse and the following parameters: TE/TR/TI=3.04/2100/785 ms, flip angle=13°, 800 µm
isotropic resolution, 200 mm FOV, 5-min duration (35-min total).
HCP
Dataset Name: HCP
Project Name: Human Connectome Project

The Human Connectome Project (HCP) was an ambitious 5-year effort to characterize brain
connectivity and function and their variability in healthy adults. Participants were drawn from the May
2017 public data release from the HCP (S1200). The HCP is a large-scale project comprising 1,113
individuals with MRI data (606 females, age range 22-37 years at the time of scanning) of varying
ethnicities (http://humanconnectome.org/). The HCP contains 143 monozygotic twin pairs and 85
dizygotic twin pairs, as well as unrelated individuals.

Inapplicable.

Images were acquired using a customized Siemens Skyra 3-T scanner with a 32-channel head coil. For
details on data acquisition and preprocessing, see Glasser et al. (2013).
Glasser, M. F. et al. The minimal preprocessing pipelines for the Human Connectome Project.
Neuroimage 80, 105–124 (2013).
Acknowledgements
ENIGMA Center. P.M.T., N.J., and D.P.H. were supported in part by a grant from the NIH Big Data
to Knowledge (BD2K) Program (U54 EB020403).
Addiction_Cousijn. This study investigated the predictive role of neurocognitive functions in the
progression from cannabis use to dependence in at-risk young adults. JC & AG received funding for
the Cannabis Prospective study from ZonMW grant no.31180002 from the Netherlands Organization
for Scientific Research (NWO)
Addiction_DStein. The Meth-CT studies investigate structural and functional brain alterations in
methamphetamine-dependent individuals compared to healthy controls, and the neural underpinnings
of psychotic symptoms. Research was supported by the Department of Psychiatry and Mental Health
and the Human Research Ethics Committee, University of Cape Town, and the Medical Research
Council, South Africa.
Addiction_EStein. Data collection was supported by the Intramural Research Program of NIDA/NIH.
Addiction_Foxe. These projects studied cognitive control and reward processing in current and
abstinent cocaine users. HG & JF received funds from NIDA: R01-DA014100
Addiction_Garavan. This data was supported by USPHS grant from the National Institute on Drug
Abuse: DA01865-01, Australian Research Council Grant (RH) DP0556602 and Australian National
Health and Medical Research Council Career Development Award 519730 (RH).
Addiction_London. These projects examined how structural and functional brain abnormalities were
associated with attention, working memory (R01DA015179, EDL), response inhibition, cognitive
flexibility and decision making in methamphetamine users (R01DA020726, P20DA022539, EDL).
Additional support for these projects came from the Thomas P. and Katherine K. Pike Chair in
Addiction Studies and the Endowment from the Marjorie Greene Family Trust (EDL).
Addiction_Luijten. ML & DV received funding for the DABIS study from VIDI grant no.016.08.322
from the Netherlands Organization for Scientific Research (NWO) awarded to Ingmar H A Franken.
Addiction_NESDA-AD. ZS & DV received funding for the NESDA-AD study from ZonMW grant
no. 31160004 from the Netherlands Organization for Scientific Research (NWO).
Addiction_NIAAA. Data collection by RM was supported by the Intramural Clinical and Biological
Research (DICBR) Program of the National Institute on Alcohol Abuse and Alcoholism (NIAAA),
National Institutes of Health.
Addiction_Orr. The study was approved by the School of Psychology in Trinity College Dublin and
was conducted in accordance with the declaration of Helsinki.
Addiction_Paulus. MP received funding from NIMH: R01 DA018307

Addiction_Sinha. Rajita Sinha received funds from NIH/NIDA: P50-DA016556, R01-AA013892,
UL1-DE019586, PL1-DA024859
Addiction_TrIp. LS & DV received funding for the TrIP study from ZonMW grant no. 31160003
from the Netherlands Organization for Scientific Research (NWO).
Addiction_Yucel. This study was funded by National Health and Medical Research Council
(NHMRC) of Australia (Project Grant 459111). MY was supported by a National Health and Medical
Research Council Fellowship (#1117188) and the David Winston Turner Endowment Fund.
ADPG. AG & RvH received funding for the ADPG study from ZonMW grant no.91676084 from the
Netherlands Organization for Scientific Research (NWO).
ADHD_Wuerzburg. This work was supported by the German Research Foundation (DFG; KFO
125/2, project 7 to PP).
BIG. The Brain Imaging Genetics (BIG) database was established in Nijmegen in 2007. This resource
is now part of Cognomics, a joint initiative by researchers of the Donders Centre for Cognitive
Neuroimaging, the Human Genetics and Cognitive Neuroscience departments of the Radboud
University Medical Center, and the Max Planck Institute for Psycholinguistics. The Cognomics
Initiative is supported by the participating departments and centres and by external grants, i.e. the
Biobanking and Biomolecular Resources Research Infrastructure (Netherlands) (BBMRI-NL), the
Hersenstichting Nederland, and the Netherlands Organisation for Scientific Research (NWO). The
research on BIG also receives funding from the European Community‘s Seventh Framework
Programme (FP7/2007–2013) under grant agreements #602450 (IMAGEMEND) and #602805
(Aggressotype) and from the National Institutes of Health (NIH) Consortium grant U54 EB020403,
supported by a cross-NIH alliance that funds Big Data to Knowledge Centers of Excellence. We
would also like to thank Hans van Bokhoven for his contributions to the Cognomics initiative and to
all persons who kindly participated in this research. In addition, AF Marquand gratefully
acknowledges support from the Language in Interaction project, funded by the NWO under the
Gravitation Programme (grant 024.001.006).
BIL&GIN. The BIL&GIN was designed to allow an in-depth exploration of hemispheric
specialization and of its variability in human. A local ethics committee (CCPRB Basse-Normandie)
approved the experimental protocol.
Bipolar Kids and Sibs. This study and research team are supported by the Australian National
Medical and Health Research Council (programme grant 1037196; project grants 1066177 and
1063960), the Lansdowne Foundation and the Janette Mary O’Neil Research Fellowship (to JMF).
BRAINN. The Brazilian Institute of Neuroscience and Neurotechnology (BRAINN) was launched in
2013 by FAPESP (SÃO PAULO RESEARCH FOUNDATION, grant 2013/07559-3) as a Research,
Innovation and Dissemination Center (RIDC).
CAMH. The CAMH dataset was collected in Toronto with support from the CAMH Foundation and
the Canadian Institutes of Health Research.
CIAM. The CIAM study was conducted at the University of Cape Town, Department of Psychiatry
and Mental Health, and was supported by the Department of Psychiatry and Mental Health and
University Research Committee, University of Cape Town, South Africa and the National Research
Foundation South Africa.
CliNG. Recruitment for the CliNG study sample was partially supported by the Deutsche
Forschungsgemeinschaft (DFG) via the Clinical Research Group 241 ‘Genotype-phenotype
relationships and neurobiology of the longitudinal course of psychosis’, TP2 (PI Gruber;
http://www.kfo241.de; grant number GR 1950/5-1).
CODE. The CODE cohort was collected from studies funded by Lundbeck and the German Research
Foundation (WA 1539/4-1, SCHN 1205/3-1, SCHR 443/11-1).
Colm_UCSF. This work was supported by the Brain and Behavior Research Foundation grant
(formerly NARSAD) to T.T.Y. and by a US National Institute of Mental Health (NIMH) grant to
T.T.Y. (R01MH085734).
DIP GRONINGEN. Data collection for DIP, as contributed to ENIGMA projects, was funded by the
Gratama Foundation, the Netherlands.
EPIGEN-Ireland. The work was supported by research grants from the Science Foundation Ireland
(Research Frontiers Program award 08/RFP/GEN1538) and Brainwave–the Irish Epilepsy
Association.
ESTADO-NARSAD. The present investigation was supported by a 2010 NARSAD Independent
Investigator Award (NARSAD: The Brain and Behavior Research Fund) awarded to Geraldo F.
Busatto. Geraldo F. Busatto is also partially funded by CNPq-Brazil. Marcus V. Zanetti is funded by
FAPESP, Brazil (no. 2013/03905-4).
GBB. This research was supported by the National Natural Science Foundation of China (31271087;
31470981; 31571137; 31500885), National Outstanding young people plan, the Program for the Top
Young Talents by Chongqing, the Fundamental Research Funds for the Central Universities
GEB^2. The project was supported by National Natural Science Foundation of China (31230031,
31221003, 31471067, 31470055).
JPCapeTown. This work was supported by the Medical Research Council of South Africa, the
Obsessive-Compulsive Foundation (Dan J. Stein), the National Research Foundation of South Africa
(Christine Lochner), and an unrestricted grant from Lundbeck H/S, and we acknowledge the
contribution of our research assistants.
Lothian Birth Cohort. Data collection was supported by the Disconnected Mind project, funded by
Age UK. J.M.W. is partly funded by the Scottish Funding Council as part of the SINAPSE
Collaboration. The work was undertaken by The University of Edinburgh Centre for Cognitive Ageing
and Cognitive Epidemiology, part of the cross-council Lifelong Health and Wellbeing Initiative
(MR/K026992/1). Funding from the Biotechnology and Biological Sciences Research Council
(BBSRC) and MRC is gratefully acknowledged. We thank the study participants. We also thank
Catherine Murray for recruitment of the participants and the radiographers and other staff at the Brain
Research Imaging Centre.
MacMasterMDD. Funding from the Halifax Stanley Centre. Support for this research in part from the
University of Calgary.
MAS. We would like to acknowledge and thank the Sydney MAS participants, their supporters and
the Sydney MAS Research Team. Sydney MAS is supported by the National Health and Medical
Research Council (NHMRC) Program Grants (350833, 56896, 109308).
MCIC. This work was supported primarily by the Department of Energy DE-FG02-99ER62764
through its support of the Mind Research Network (MRN, formerly known as the MIND Institute) and
the consortium as well as by the National Association for Research in Schizophrenia and Affective
Disorders (NARSAD) Young Investigator Award (to SE) as well as through the Blowitz-Ridgeway
and Essel Foundations, and through NWO ZonMw TOP 91211021, the DFG research fellowship (to
SE), the Mind Research Network, National Institutes of Health through NCRR 5MO1-RR001066
(MGH General Clinical Research Center), NIMH K08 MH068540, the Biomedical Informatics
Research Network with NCRR Supplements to P41 RR14075 (MGH), M01 RR 01066 (MGH), NIBIB
R01EB006841 (MRN), R01EB005846 (MRN), 2R01 EB000840 (MRN), 1RC1MH089257 (MRN), as
well as grant U24 RR021992, P20RR021938/P20GM103472 and R01MH094524.
NESDA. The infrastructure for the NESDA study (http://www.nesda.nl) is funded through the
Geestkracht program of the Netherlands Organisation for Health Research and Development (Zon-
Mw, grant no 10-000-1002) and is supported by participating universities and mental health care
organizations (VU University Medical Center, GGZ inGeest, Arkin, Leiden University Medical
Center, GGZ Rivierduinen, University Medical Center Groningen, Lentis, GGZ Friesland, GGZ
Drenthe, Scientific Institute for Quality of Healthcare (IQ healthcare), Netherlands Institute for Health
Services Research (NIVEL) and Netherlands Institute of Mental Health and Addiction (Trimbos
Institute).
Neuro-ADAPT. OK received support for the Neuro-ADAPT study from VICI grant no. 453.08.01
from the Netherlands Organization for Scientific Research (NWO) awarded to Reinout W Wiers.
NeuroIMAGE. This work was supported by NIH Grant R01MH62873 (to Stephen V. Faraone),
NWO Large Investment Grant 1750102007010 and NWO Brain & Cognition an Integrative Approach
grant (433-09-242) (to Jan Buitelaar), and grants from Radboud University Nijmegen Medical Center,
University Medical Center Groningen and Accare, and VU University Amsterdam. The research
leading to these results also received funding from the European Community’s Seventh Framework
Programme (FP7/2007– 2013) under grant agreement numbers 278948 (TACTICS), 602450
(IMAGEMEND) and n° 602805 (Aggressotype), and from the European Community’s Horizon 2020
Programme (H2020/2014 – 2020) under grant agreement n° 643051 (MiND). Barbara Franke is
supported by a Vici grant from NWO (grant number 016-130-669). In addition, Jan Buitelaar and
Barbara Franke are supported by a grant for the ENIGMA Consortium (grant number U54 EB020403)
from the BD2K Initiative of a cross-NIH partnership.
NSIOCDS_1.5T_Adults. The structural MRI data were obtained as part of three funded projects
Government of India grants to the Wellcome-DBT India Alliance grant to Dr. Venkatasubramanian
(500236/Z/11/Z), Prof. Reddy (SR/S0/HS/0016/2011) and Dr. Narayanaswamy (DST INSPIRE
faculty grant -IFA12-LSBM-26) of the Department of Science and Technology; the Government of
India grants to Prof. Reddy No.BT/PR13334/Med/30/259/2009) and Dr. Narayanaswamy
(BT/06/IYBA/2012) of the Department of Biotechnology.
NSIOCDS_3T_Adults. The structural MRI data were obtained as part of three funded projects
NSIOCDS_3T_Child. The structural MRI data were obtained as part of three funded projects
NUIG. This NUI Galway study was supported by the NUI Galway Millennium Fund and grant
funding from the Health Research Board (HRA_POR/2011/100).
OATS. We would like to acknowledge and thank the OATS participants, their supporters and the
OATS Research Team. OATS is supported by a National Health and Medical Research Council
(NHMRC)/Australian Research Council Strategic Award (Grant 401162) and the NHMRC Project
Grant (1045325). OATS was facilitated through access to the Australian Twin Registry, which is
funded by the NHMRC Enabling Grant 310667.
OCD_Cheng_1.5T. This study was supported the Funding of Yunnan Provincial Health Science and
Technology Plan (2010NS016, 2011WS008), the united founding of Yunnan Administration of
Science & Technology and Kunming Medical College(2011FB167).
OCD_Cheng_3T. This study was supported by grants from National Natural Science Foundation of
China (NSFC) (81101005), the Ministry of Science and Technology of Yunnan
Province(2012FB158), the Funding of Yunnan Provincial Health Science and Technology Plan
(2014NS171, 2014NS172), the united founding of Yunnan Administration of Science & Technology
and Kunming Medical College(2011FB167).
OCD_Huyser. The studies were supported by a grant from the Amsterdam school of neuroscience
(ONWA) for scan costs.
OCD_Lazaro. The studies were supported by two grants from Marato_TV3 Foundation (01/2010,
091710).
OCD_Mataix-Cols. These structural scans come from a series of studies conducted at King’s College
London and funded by the Wellcome Trust (Mary L Phillips, PI) and a pump priming grant from the
South London and Maudsley Trust, London (project grant no. 064846; David Mataix-Cols PI).
OCD_VUmc 1.5T. Supported by the Dutch Organization for Scientific Research (NWO) (grants 912-
02-050, 907-00-012, 940-37-018, and 916.86.038).
OCD_VUmc 3T. Supported in part by the Netherlands Society for Scientific Research (NWO-
ZonMw VENI grant 916.86.036 to Dr. van den Heuvel; NWO-ZonMw AGIKO stipend 920-03-542 to
Dr. de Vries), and a NARSAD Young Investigators Award to Dr. van den Heuvel, Amsterdam Brain
Imaging Platform to Dr. van den Heuvel, the Netherlands Brain Foundation (2010(1)-50 to Dr. van
den Heuvel).
Oslo Malt. The study is funded by the Research Council of Norway (167153/V50, 204966/F20), the
South-Eastern Norway Regional Health Authority, Oslo University Hospital, and research grants from
Mrs. Aslaug Throne-Holst and from the Ebbe Frøland Foundation.
OXEOP. MRC funded grant number: G0500092 - Anatomical connectivity in early onset
schizophrenia
QTIM. QTIM is funded by the National Institutes of Health (project ROI HD HD050735; NIH Award
1U54EB020403-01, subaward no. 56929223) and the NHMRC (1009064, 496682). Ethics approval
was given by the Human Research Ethics Committees of the Queensland Institute of Medical
Research, University of Queensland, and Uniting Health Care. We thank the twins and siblings for
their participation, Marlene Grace and Ann Eldridge for twin recruitment, Aiman Al Najjar and other
radiographers for scanning, and Kerrie McAloney and Daniel Park for research support.
R_SCZ. The R_SCZ database has been supported by MHRC and by a research grant from The
Russian Foundation for Basic Research (grant code 15-06-05758 A; grantee Dr. Irina Lebedeva, PhD,
DrSci (biol), the head of the Laboratory of Neuroimaging and Multimodal analysis, MHRC).
SBP. The SBP is supported by grants from the Swedish Medical Research Council (K2014-62X-
14647-12-51, K2010-61P-21568-01-4, and K2013-61X-08276-26-4), the Swedish foundation for
Strategic Research (KF10-0039), the Swedish Brain foundation (FO2016-0176), and the Swedish
Federal Government under the LUA/ALF agreement (ALFGBG-426721).
Seoul I. This study was supported by the Korean Research Foundation (1998-003-F00172), Korean
Health Research and Development Grant (HMP-98-N-2-0029), Korea Research Foundation Grant
(KRF-2001-044-F00182), Korean Research Foundation (2001-041-F00182), Seoul National
University Hospital Research Fund (11-2003-001), and Brain Research Center of the 21st Century
Frontier Research Program by Ministry of Science and Technology of Republic of Korea
(M103KV010007 04K2201 007 10).
Seoul II. This study was supported by grants (M103KV010012-06K2201-01210, 2009K001270, and
2010K000817) from Brain Research Center of the 21st Century Frontier Research Program funded by
the Ministry of Science and Technology of the Republic of Korea, a grant (M10644020003-08N4402-
00310) from the Cognitive Neuroscience Program of the Korean Ministry of Science and Technology
of the Republic of Korea, the Korea Research Foundation grants funded by the Korean Government
(KRF-2007-313-E00306 and KRF-2008-313-E00341), World Class University program through the
Korea Science and Engineering Foundation funded by the Ministry of Education, Science and
Technology (R31-10089, and R32-10142), a grant from the Seoul National University Hospital
Research Fund (04-2008-104), and a grant from the National Research Foundation of Korea (2012-
0005150) funded by the Ministry of Education, Science and Technology (MEST) of the Republic of
Korea.
Seoul III. This study was supported by National Research Foundation of Korea grant funded by the
Ministry of Education, Science and Technology (MEST) of the Republic of Korea (2011-0015639 and
2012-0005150), a grant of the Korea Health Technology R&D Project, Ministry of Health & Welfare
of the Republic of Korea (A110094), and Basic Science Research Program through the National
Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning
(2013R1A2A1A03071089).
SHIP. SHIP is part of the Community Medicine Research net of the University of Greifswald,
Germany, which is funded by the Federal Ministry of Education and Research (grants no. 01ZZ9603,
01ZZ0103, and 01ZZ0403), the Ministry of Cultural Affairs and the Social Ministry of the Federal
State of Mecklenburg-West Pomerania. MRI scans in SHIP have been supported by a joint grant from
Siemens Healthineers, Erlangen, Germany and the Federal State of Mecklenburg-West Pomerania.
SHIP-TREND. SHIP is part of the Community Medicine Research net of the University of
Greifswald, Germany, which is funded by the Federal Ministry of Education and Research (grants no.
01ZZ9603, 01ZZ0103, and 01ZZ0403), the Ministry of Cultural Affairs and the Social Ministry of the
Federal State of Mecklenburg-West Pomerania. MRI scans in SHIP-TREND have been supported by a
joint grant from Siemens Healthineers, Erlangen, Germany and the Federal State of Mecklenburg-
West Pomerania.
Stanford. The Stanford dataset was established with the support of NIMH Grant R01MH59259 to Ian
Gotlib, and the National Science Foundation Integrative Graduate Education and Research Traineeship
(NSF IGERT) Recipient Award 0801700 and National Science Foundation Graduate Research
Fellowship Program (NSF GRFP) DGE-1147470 to Matthew Sacchet.
Wellcome Study. This study was funded by the Wellcome Trust, UK.
Youth-TOP/NORMENT EOP. Funding is provided by the Norwegian Research Council (NFR), the
South-Eastern Norway Regional Health Authority and the KG Jebsen Foundation.
TOP3T_2. The TOP study was supported by the Research Council of Norway (#160181, 190311,
223273, 213837, 249711), the South-East Norway Health Authority (2014114, 2014097, 2017- 112),
and the Kristian Gerhard Jebsen Stiftelsen (SKGJ-MED-008) and the European Community's Seventh
TOP1.5T. The TOP study was supported by the Research Council of Norway (#160181, 190311,
HUBIN_KASP. KaSP was supported by the Swedish Research Council (K2015-62X-15077-12-3),
and by grants from the Swedish Medical Research Council (SE: 2009-7053; 2013-2838; SC: 523-
2014-3467), the Swedish Brain Foundation, Åhlén-siftelsen, Svenska Läkaresällskapet, Petrus och
Augusta Hedlunds Stiftelse, Torsten Söderbergs Stiftelse, the AstraZeneca-Karolinska Institutet Joint
Research Program in Translational Science, Söderbergs Königska Stiftelse, Professor Bror Gadelius
Minne, Knut och Alice Wallenbergs stiftelse, Stockholm County Council (ALF and PPG), Centre for
Psychiatry Research, KID-funding from the Karolinska Institutet. The HUBIN study was supported by
the Swedish Research Council (grant numbers K2015-62X-15077-12-3), the regional agreement
between Karolinska Institutet and Stockholm County Council, the Karolinska Institutet and the Knut
and Alice Wallenberg Foundation.
Muenster. This work was funded by the German Research Foundation (SFB-TRR58, Project C09 to
UD) and the Interdisciplinary Center for Clinical Research (IZKF) of the medical faculty of Münster
(grant Dan3/012/17 to UD).
FOR2107. This work was funded by the German Research Foundation (DFG, grant FOR2107 KI
588/14-1 to TK, KO4291/3-1 to AK and DA1151/5-1 to UD).
FIDMAG-Barcelona. This work was supported by the Catalonian Government (2014-SGR-1573) and
by the Plan Nacional de I+D+i 2008–2011 and 2013–2016: Juan de la Cierva-formación contract
(FJCI-2015-25278 to PF-C). Also by the Instituto de Salud Carlos III and co-funded by European
Union (ERDF/ESF, “Investing in your future”): Miguel Servet Research Contracts (MS14/00041 to JR
and CPII16/00264 to EP-C) and Research Project Grants (PI15/00277 to EC-R, PI11/01766 and
PI14/00292 to JR, PI14/01148 to EP-C and PI14/01151 to RS).
ADHD-ACPU. Scans taken as part of National competitive research grant funding awarded to
Alasdair Vance and Timothy Silk.
ADHD_NICAP. The study was funded by the National Medical Health and Research Council of
Australia (NHMRC; project grant #1065895).
ADHD_OHSU. The OHSU dataset was established through several Foundation grants and grants
from the National Institutes of Health: R01 MH115357 (MPI: Fair, Nigg), R56 MH086654 (MPI:
Nigg, Fair), R01 MH086654 (PI: Nigg), R01 MH099064 (PI: Nigg), R01 MH096773 (PI: Fair),
DeStefano Family Innovation Fund (PI: Fair), R00 MH091238 (PI: Fair), Oregon Clinical and
Translational Research Institute (UL1TR000128).
ADHD_UCHZ. This work was supported by the University Research Priority Program “Integrative
Human Physiology” at the University of Zurich.
ADHD_Dundee. This work was supported by a Tenovus-Scotland initiative (a local trust) and by
SINAPSE (www.sinapse.ac.uk), which included a SINAPSE-SPIRIT industry partnership with
Siemens Medical (a SINAPSE studentship for Blair Johnston).
TOP3T_1. The TOP study was supported by the Research Council of Norway (#160181, 190311,
ADHD_IMPACTNL. This study was supported by grants from the Netherlands Organization
for Scientific Research (NWO), i.e. the NWO Brain & Cognition Excellence Program (grant
433-09-229) and a Vici grant to BF (grant 016-130-669), and by grants from the Netherlands
Brain Foundation (grant 15F07[2]27) and BBMRI-NL (grant CP2010-33). The research
leading to these results also received funding from the European Community’s Seventh
Framework Programme (FP7/2007 – 2013) under grant agreements n° 602805 (Aggressotype)
and n° 602450 (IMAGEMEND), and from the European Community’s Horizon 2020
Programme (H2020/2014 – 2020) under grant agreement n° 643051 (MiND). In addition, the
work was supported by a grant for the ENIGMA Consortium (grant number U54 EB020403)
from the BD2K Initiative of a cross-NIH partnership.
ADHD_MTA. Data collection was funded in part by the National Institute on Drug Abuse (Contract
#: HHSN271200800009C).
COBRE. This research was supported by NIH1R01-EB006841, NIH1R01-EB005846, NIH2R01-
EB000840, NIH1 P20 RR021938-01 and DOEDEFG02-08ER64581 (to VDC); the national high tech
development plan (863 plan) 2015AA020513 (to JS); R01 MH65304 and VA CSR&D IIR-04-212-3
(to JMC). TW is supported by the Netherlands Organization for Health Research and Development
(ZonMw) TOP project number 91211021 and the Simons Foundation Autism Research Initiative
(SFARI - 307280).
SI Conflicts of interest
The ENIGMA co-authors declare no conflicts of interest except for the authors below:
Theo Van Erp consulted for Roche Pharmaceuticals and has a contract with Otsuka Pharmaceutical, Ltd.
Anders Dale is a Founder of CorTechs Labs, Inc. He serves on the Scientific Advisory Boards of
CorTechs Labs and Human Longevity, Inc., and receives research funding through a Research
Agreement with General Electric Healthcare.
Stephen Faraone received income, potential income, travel expenses continuing education support
and/or research support from Lundbeck, KenPharm, Rhodes, Arbor, Ironshore, Shire, Akili Interactive
Labs, CogCubed, Alcobra, VAYA, Sunovion, Genomind and NeuroLifeSciences. With his institution,
he has US patent US20130217707 A1 for the use of sodium-hydrogen exchange inhibitors in the
treatment of ADHD.
Paulo Mattos was on the speakers’ bureau and/or acted as consultant for Janssen-Cilag, Novartis, and
Shire in the previous five years; he also received travel awards to participate in scientific meetings from
those companies. The ADHD outpatient program (Grupo de Estudos do Déficit de Atenção/Institute of
Psychiatry) chaired by Dr. Mattos has also received research support from Novartis and Shire.The
funding sources had no role in the design and conduct of the study; collection, management, analysis,
or interpretation of the data; or preparation, review, or approval of the manuscript.
Tobias Banaschewski served in an advisory or consultancy role for Hexal Pharma, Lilly, Medice,
Novartis, Oxford outcomes, PCM scientific, Shire and Viforpharma. He received conference support or
speaker’s fee by Janssen McNeil, Lilly, Medice, Novartis and Shire. He is/has been involved in clinical
trials conducted by Shire & Viforpharma. The present work is unrelated to the above grants and
relationships.
Katya Rubia received speaker's fees form Shire, Medice and a grant from Lilly for another project.
Jan Haavik has received speaker fees from Lilly, Novartis and Janssen Cilag.
Steve Faraone has received income, travel expenses and/or research support from, and/or has been on
an Advisory Board for, and/or participated in continuing medical education programs sponsored by:
Pfizer, Ironshore, Shire, Akili Interactive Labs, CogCubed, Alcobra, VAYA Pharma, Neurovance,
Impax, NeuroLifeSciences, Otsuka, McNeil, Janssen, Novartis, Eli Lilly and the NIH. With his
institution, he has US patent US20130217707 A1 for the use of sodium-hydrogen exchange inhibitors
in the treatment of ADHD. He receives royalties from books published by Guilford Press: Straight Talk
about Your Child’s Mental Health; Oxford University Press: Schizophrenia: The Facts; Elsevier, ADHD:
Non-Pharmacologic Treatments
Kerstin Konrad received speaking fees from Medice, Lilly and Shire.
Josep-Antoni Ramos was on the speakers’ bureau and/or acted as consultant for Eli-Lilly, Janssen-Cilag,
Novartis, Shire, Lundbeck, Almirall and Rubió in the last 3 years. He also received travel awards (air
tickets + hotel) for taking part in psychiatric meetings from Janssen-Cilag, Rubió, Shire, and Eli- Lilly.
The ADHD Program chaired by him received unrestricted educational and research support from the
following pharmaceutical companies in the last 3 years: Eli-Lilly, Rovi, Ferrer, Lundbeck, Shire, and
Rubió.
Pieter Hoekstra received a research grant from Shire and was part of the advisory board of Shire.
Jan Buitelaar has been in the past 3 years a consultant to / member of advisory board of / and/or speaker
for Janssen Cilag BV, Eli Lilly, Medice, Shire, Roche, and Servier. He is not an employee of any of
these companies, and not a stock shareholder of any of these companies. He has no other financial or
material support, including expert testimony, patents, royalties.
David Coghill has been in the past 3 years a consultant to / member of advisory board of / and/or speaker
for Janssen Cilag, Eli Lilly, Medice, Shire, Novartis. He receives royalties from Oxford University Press.
He is not an employee of any of these companies, and not a stock shareholder of any of these companies.
D.P.H. is now a Senior Scientist for Janssen, Inc., but his work for this manuscript was completed while
he was a faculty member at USC.

Dr. Joseph Biederman is currently receiving research support from the following sources: AACAP,
The Department of Defense, Food & Drug Administration, Headspace, Lundbeck, Neurocentria Inc.,
NIDA, PamLab, Pfizer, Shire Pharmaceuticals Inc., Sunovion, and NIH.
Dr. Biederman has a financial interest in Avekshan LLC, a company that develops treatments for
attention deficit hyperactivity disorder (ADHD). His interests were reviewed and are managed by
Massachusetts General Hospital and Partners HealthCare in accordance with their conflict of interest
policies.
Dr. Biederman’s program has received departmental royalties from a copyrighted rating scale used for
ADHD diagnoses, paid by Ingenix, Prophase, Shire, Bracket Global, Sunovion, and Theravance; these
royalties were paid to the Department of Psychiatry at MGH.
In 2017, Dr. Biederman is a consultant for Aevi Genomics, Akili, Guidepoint, Ironshore, Medgenics,
and Piper Jaffray. He is on the scientific advisory board for Alcobra and Shire. He received honoraria
from the MGH Psychiatry Academy for tuition-funded CME courses. Through MGH corporate
licensing, he has a US Patent (#14/027,676) for a non-stimulant treatment for ADHD, and a patent
pending (#61/233,686) on a method to prevent stimulant abuse.
In 2016, Dr. Biederman received honoraria from the MGH Psychiatry Academy for tuition-funded
CME courses, and from Alcobra and APSARD. He was on the scientific advisory board for Arbor
Pharmaceuticals. He was a consultant for Akili and Medgenics. He received research support from
Merck and SPRITES.
CME courses, and from Avekshan. He received research support from Ironshore, Magceutics Inc., and
Vaya Pharma/Enzymotec.
CME courses. He received research support from AACAP, Alcobra, Forest Research Institute, and
Shire Pharmaceuticals Inc.
In previous years, Dr. Biederman received research support, consultation fees, or speaker’s fees for/from
the following additional sources: Abbott, Alza, APSARD, AstraZeneca, Boston University, Bristol
Myers Squibb, Cambridge University Press, Celltech, Cephalon, The Children’s Hospital of Southwest
Florida/Lee Memorial Health System, Cipher Pharmaceuticals Inc., Eli Lilly and Co., Esai, ElMindA,
Fundacion Areces (Spain), Forest, Fundación Dr.Manuel Camelo A.C., Glaxo, Gliatech, Hastings
Center, Janssen, Juste Pharmaceutical Spain, McNeil, Medice Pharmaceuticals (Germany), Merck,
MGH Psychiatry Academy, MMC Pediatric, NARSAD, NIDA, New River, NICHD, NIMH, Novartis,
Noven, Neurosearch, Organon, Otsuka, Pfizer, Pharmacia, Phase V Communications, Physicians
Academy, The Prechter Foundation, Quantia Communications, Reed Exhibitions, Shionogi Pharma Inc,
Shire, the Spanish Child Psychiatry Association, The Stanley Foundation, UCB Pharma Inc., Veritas,
and Wyeth.
Henry Brodaty is on the Advisory Board for Nutricia and has conducted an Alzheimer’s drug trial for
Tau Therapeutics.

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Mapping Cortical Brain Asymmetry in 17,141 Healthy Individuals Worldwide via the ENIGMA Consortium

Abbreviated title: Mapping Cortical Brain Asymmetry

Authors from the ENIGMA Laterality Working Group

3. Department of Clinical Neuroscience, Osher Centre, Karolinska Institutet, Stockholm, Sweden.

12. Department of Psychology, University of Oregon, Eugene OR, USA.

13. National Ageing Research Institute, Melbourne, Australia.

20. Mathematics and Statistics, Murdoch University, Perth, Australia.

21. Laboratory of Neuroimaging, Department of Neurology, University of Campinas.

23. Brain Research Imaging Centre, University of Edinburgh, Edinburgh, UK.

25. Department of Clinical Radiology, School of Medicine, University of Münster, Germany.

26. Discipline of Psychiatry, University of Adelaide, Australia.

27. Department of Psychology, University of Würzburg, Germany, Würzburg, Germany.

28. Department of Psychiatry, Harvard Medical School, Boston, Mass, USA.

30. Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands.

32. Amsterdam Neuroscience, Amsterdam, The Netherlands.

43. Karakter Child and Adolescent Psychiatry, Nijmegen, The Netherlands.

44. Department of Cognitive Neuroscience, Radboud university, Nijmegen, The Netherlands.

45. Department of Psychiatry, University of Münster, Germany.

47. The Mind Research Network, Albuquerque, NM, USA.

51. FIDMAG Germanes Hospitalaries Research Foundation, Barcelona, Spain.

52. CIBERSAM, Centro de Investigación Biomédica en Red de Salud Mental, Spain.

55. Departments of Psychiatry and Neurosciences, University of New Mexico.

62. School of Psychology, Southwest University, Chongqing, China.

69. Departments of Paediatrics and Psychiatry, University of Melbourne. Victoria, Australia.

75. Department of Developmental Psychology, University of Amsterdam, Amsterdam, the Netherlands.

83. Neurology Department, St. James's Hospital, Dublin, Ireland.

88. Department of Neurology, Oslo University Hospital, Oslo, Norway.

89. University of Cincinnati College of Medicine, Cincinnati, OH, USA.

90. Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

92. Department of Psychiatry, Oregon Health & Science University, USA.

101. Neuroscience Research Australia, Sydney, NSW, Australia.

103. Department of Psychiatry, University of Vermont, Burlington, VT, USA.

104. Laboratory of Neuroimaging, Department of Neurology, University of Campinas, Campinas, Brazil.

105. Department of Psychology, Stanford University, USA.

108. Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Germany.

109. German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Germany.

112. Department of Psychiatry, Haukeland University Hospital, Bergen, Norway.

113. Queensland Brain Institute, University of Queensland, Brisbane, Australia.

116. Department of Cognitive Psychology, VU University Amsterdam, Amsterdam, The Netherlands.

117. Department of Clinical Neuropsychology, VU University Amsterdam, Amsterdam, The Netherlands.

118. School of Psychological Sciences, University of Melbourne, Melbourne, Australia.

121. Department of Psychology, Stanford University, Stanford, CA, USA.

124. Department of Psychiatry, Amsterdam, The Netherlands.

125. Department of Clinical Medicine, University of Bergen, Bergen, Norway.

130. University Department of Psychiatry, Warneford Hospital, Oxford, UK .

134. Mental Health Research Center, Moscow, Russia.

137. School of Psychology, Trinity College, Dublin, Ireland.

138. Trinity College Institute of Neuroscience, Dublin, Ireland.

140. Beth Israel Deaconess Medical Center, Boston, MA, USA.

141. Olin Neuropsychiatry Research Center, Hartford CT, USA.

148. August Pi I Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.

149. Department of Medicine, University of Barcelona, Barcelona, Spain.

152. Neuroscience Research Australia, Sydney, NSW, Australia .

153. University of New Mexico, Albuquerque, New Mexico.

158. Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA.

162. Behavioural Science Institute, Radboud University, Nijmegen, The Netherlands.

167. Alberta Children's Hospital Research Institute, Calgary AB, Canada.

171. Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

173. Department of Psychiatry, Trinity College Dublin, Dublin, Ireland.