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Cancer Patho

In 3 sentences: Mutations from environmental factors or inherited genes can cause DNA damage in normal cells. If the DNA repair is unsuccessful, mutations accumulate in the genome and can activate oncogenes or inactivate tumor suppressor genes. This can lead to uncontrolled cell growth and division resulting in the formation of malignant tumors through clonal expansion and acquisition of further mutations.

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Trisha Dicang
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34 views1 page

Cancer Patho

In 3 sentences: Mutations from environmental factors or inherited genes can cause DNA damage in normal cells. If the DNA repair is unsuccessful, mutations accumulate in the genome and can activate oncogenes or inactivate tumor suppressor genes. This can lead to uncontrolled cell growth and division resulting in the formation of malignant tumors through clonal expansion and acquisition of further mutations.

Uploaded by

Trisha Dicang
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
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Acquired (environmental DNA Normal Cell

damaging agents: Inherited Mutations


in:
 Chemicals Successful DNA repair
 Radiation  Genes
 Viruses affecting DNA
DNA damage
repair
Failure of DNA repair  Genes
affecting cell
growth
Mutations in the Genome of
apoptosis
Somatic Cells

Activavtion of growth
Alterations of genes Inactivation of Cancer
promoting Oncogenes
that regulate Apoptosis Suppressor Genes

Expression of altered Gene products


And loss of regulatory Gene products

Colonal expansion

Additional mutations (progression)

Heterogenity

Malignant Neoplasm

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