Gen Chem Week 1

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1.

Scientific Method is the approach that science uses to gain knowledge, based on making observations,
testing theories or hypotheses by experimentation and formulating conceptual models and theories
based on experiments.

2.
Hypothesis is a proposal made to explain an observation and/or a tentative explanation of some
regularity of nature.

Law a concise statement or mathematical equation about a fundamental relationship or regularity of


nature.

Theory is a tested explanation of basic natural phenomena.

3.
Qualitative data are observations or information characterized by measurement on a categorical scale,
i.e., a dichotomous or nominal scale, or, if the categories are ordered, an ordinal scale.  Examples are
sex, hair color, death or survival, and nationality. Qualitative data can enrich understanding of complex
problems and help to explain why things happen.

Quantitative  data are data in numerical quantities, such as continuous measurements or counts or
binary variables.  Qualitative data  can be coded to create quantitative data.

4.

The term precision refers to the closeness of the set of values obtained from identical measurements of
a quantity. Accuracy is a related term; it refers to the closeness of a single measurement to its true
value.

Gas chromatography and Paper chromatography

5. Name the SI units that are important in clinical chemistry.

The SI base units that are important in clinical chemistry are:

Units Test Name (Chemistry Section)


Units per Liter (U/L) SGPT/ALT, SGOT/AST, ALP, Total ACP, AMS, LDH
Millimoles per Liter (mmol/L) Blood Urea Nitrogen, Sodium, Potassium,
Chloride, Anion gap, Total CO2
Micromoles per Liter (mol/L) Fructosamine
Milligrams per deciliter (mg/dL) RBS, FBS, GTT, Cholesterol, TAG, LDL, HDL,
Creatinine, Uric acid, Total Bilirubin, Direct
Bilirubin, Indirect Bilirubin, Calcium, Inorganic
Phosphate, Total Calcium, Ionized Calcium
Millimeters of Mercury (mmHg) pCO2, pO2
Milliequivalent per Liter (mEq/L) Magnesium, HCO3
Milligrams per Liter (mg/L) CRP
Micrograms per deciliter (g/dL) Ammonia, Iron, TIBC, T4
Percent (%) HbA1c, % Transferrin saturation, O2 saturation, T3
Uptake
Grams per deciliter (g/dL) Total Protein, Albumin, Globulin, α1-globulin, α2-
globulin, β-globulin, γ-globulin
Milliliters per minute (mL/min) Creatinine clearance, Renal plasma flow (PAH),
Renal blood flow (PSP)
Milliosmoles per Kilogram Serum osmolality, Urine osmolality
Ehrlich units per 2 hours (Ehrlich units per day) Urine urobilinogen
Ehrlich units per 24 hours Stool urobilinogen
Nanograms per deciliter (ng/dL) T3
Nanograms per milliliter (ng/mL) Prostatic ACP
Units per milliliter (U/mL) LPS

6. Give the SI units for expressing the following:

a. Length – Meter
b. Volume – Cubic meter
c. Mass – Kilogram
d. Time – Second
e. Energy – Joule
f. Temperature – Kelvin
7. Write the numbers represented by the following prefixes:

a. Mega – 1,000,000
b. Kilo – 1,000
c. Deci – 0.1
d. centi – 0.01
e. milli – 0.001
f. micro – 0.000001
g. nano – 0.000000001
h. pico – 0.0000000000001

8.
Scientific notation is used to express very large or very small numbers conveniently. It allows easy
comparison between numbers that would otherwise require counting zeroes.

Scientific notation is the representation of a number in the form A×10n, where A is a number with a
single nonzero digit to the left of the decimal point and n is an integer, or whole number. In scientific
notation, the measurement 900 cm precise to two significant figures is written 9.0 102 cm. If precise to
three significant figures,
it is written 9.00 102 cm. Scientific notation is also convenient for expressing very
large or very small quantities. It is much easier (and simplifies calculations) to write
the speed of light as 3.00 108 (rather than as 300,000,000) meters per second.
The decimal point allows us to write whole numbers and numbers with a fractional component using a
consistent notation. It also makes operations on fractional value - addition, subtraction, multiplication
and division - simpler. It works the same for fractional amounts and for whole numbers.

9. Express the following in scientific notation:


a. 0.000000027 – 2.7 × 10-8
b. 356 – 3.56 × 102
c. 47,764 – 4.7764 × 101
d. 0.096 – 9.6 × 10-2

10. Express the following numbers as decimals:


a. 1.52 x 10-2 – 0.0152
b. 7.78 x 10-8 – 0.0000000778
UNIT CONVERSIONS
PRACTICE CALCULATIONS. Answer the following and show solution/s.

1. Carry out the following conversions:


a. 22.6 m to decimeters
10 decimeters
22.6 meters × = 226 decimeters
1 meter

b. 25.4 mg to kilograms
1 kilogram
25.4 milligrams × = 0.0000254 kilogram
1,000,000 milligram

c. 242 lb to milligrams
453,592.37 milligrams
242 pounds × = 109,769,353.54 milligrams
1 pound

d. 68.3 cm3 to cubic meters


1 meter3
68.3 cm3 × = 0.0000683 m3
1,000,000 cm3

2. The distance between two hydrogen atoms in a hydrogen molecule is 74 pm. Convert the
distance to meters.
1 meter
74 picometers × = 0.000000000074 meter
1,000, 000,000,000 picometers

3. A person’s daily intake of glucose is 0.083 lb. What is this mass in mg?
453,592.37 milligrams
0.083 pound × = 37,648.167 milligrams
1 pound

4. An average adult has about 5.2 liters of blood. What is the volume of blood in m 3?
1 cubic meter
5.2 liters × = 0.0052 m3
1000 liter

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