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    Catholic University of Health and ALLIED Email: Vc@bugando - Ac.tz Call Us: +255 (0) 28 250 0881 SCIENCE

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    ambroce
    This document contains 6 questions about medicinal chemistry: 1. It asks for the structure, classification, 3 uses, and mechanism of action of Phenoxybenzamine, which is described as a "chemical sympathectomy" due to its selective blockade of smooth muscle and heart muscle responses. 2. It asks for the structure, classification, and an explanation of why Prazosin Hydrochloride has added advantages compared to other antagonists in the management of hypertension. 3. It asks for the structure and an explanation of the mixed α/β adrenergic blocking action of Carvediol.

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    Catholic University of Health and ALLIED Email: Vc@bugando - Ac.tz Call Us: +255 (0) 28 250 0881 SCIENCE

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    ambroce
    21 views2 pages
    This document contains 6 questions about medicinal chemistry: 1. It asks for the structure, classification, 3 uses, and mechanism of action of Phenoxybenzamine, which is described as a "chemical sympathectomy" due to its selective blockade of smooth muscle and heart muscle responses. 2. It asks for the structure, classification, and an explanation of why Prazosin Hydrochloride has added advantages compared to other antagonists in the management of hypertension. 3. It asks for the structure and an explanation of the mixed α/β adrenergic blocking action of Carvediol.

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    This document contains 6 questions about medicinal chemistry: 1. It asks for the structure, classification, 3 uses, and mechanism of action of Phenoxybenzamine, which is described as a "chemical sympathectomy" due to its selective blockade of smooth muscle and heart muscle responses. 2. It asks for the structure, classification, and an explanation of why Prazosin Hydrochloride has added advantages compared to other antagonists in the management of hypertension. 3. It asks for the structure and an explanation of the mixed α/β adrenergic blocking action of Carvediol.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    21 views2 pages

    Catholic University of Health and ALLIED Email: Vc@bugando - Ac.tz Call Us: +255 (0) 28 250 0881 SCIENCE

    Uploaded by

    ambroce
    This document contains 6 questions about medicinal chemistry: 1. It asks for the structure, classification, 3 uses, and mechanism of action of Phenoxybenzamine, which is described as a "chemical sympathectomy" due to its selective blockade of smooth muscle and heart muscle responses. 2. It asks for the structure, classification, and an explanation of why Prazosin Hydrochloride has added advantages compared to other antagonists in the management of hypertension. 3. It asks for the structure and an explanation of the mixed α/β adrenergic blocking action of Carvediol.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 2

    CATHOLIC UNIVERSITY OF HEALTH AND

    ALLIED Email: [email protected] Call


    Us: +255 (0)­ 28­ 250 0881 SCIENCE

    MEDICINAL CHEMISTRY QUESTIONS

    1. Phenoxybenzamine is described as representing a “chemical sympathectomy

    because of its selective blockade of the excitatory responses of smooth muscle and of

    the heart muscle

    a. Give structure and classification of the drug

    b. Mention 3 uses

    c. And give detailed mechanism of action The α -adrenoreceptor blocking

    agents.

    2. Prazosin Hydrochloride U.S.P is A quinazoline derivative with value in the

    management of hypertension

    a. Give structure and classification of the drug

    b. Explain why its Is an antagonist with added advantages comparable to

    others.

    c.

    3. CARVEDIOL is Mixed α/β adrenergic blockers give structure and explain SARS

    for mixed action


    4. isosorbide which is basically a bicyclic form of sorbitol and is used orally to reduce

    intraocular pressure in glaucoma cases.give structure of both compound and explain

    how they work to reduce pressure.

    5. Timolol is Non selective β-blocker approved in 1978 for with no significant

    membrane- stabilizing (local nesthetic) action or intrinsic

    sympathomimeticactivity.The aromatic side is different from other -antagonists but

    the side chain is structurally identical Give structure of the drug and uses 3

    6. Explain why aryloxypropanolamine β-Blockers binds on the same receptors with

    aryloxypropanolamineβ-Blockers

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