Scribd
Upload
39 views2 pages

External Pathway of Apoptosis

The document discusses apoptosis, or programmed cell death, including its molecular mechanisms and clinical significance. It describes the internal and external pathways of apoptosis, with the external pathway involving signals from death receptors. Caspases play a key role in apoptosis through activation of caspase cascades. The document also mentions anti-apoptotic signals involving PI3K and Akt that promote cell survival.

Uploaded by

Zoya Liaquat
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
39 views2 pages

External Pathway of Apoptosis

The document discusses apoptosis, or programmed cell death, including its molecular mechanisms and clinical significance. It describes the internal and external pathways of apoptosis, with the external pathway involving signals from death receptors. Caspases play a key role in apoptosis through activation of caspase cascades. The document also mentions anti-apoptotic signals involving PI3K and Akt that promote cell survival.

Uploaded by

Zoya Liaquat
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
You are on page 1/ 2

62. Apoptosis – molecular mechanisms and biological role.

Internal and
external pathways of apoptosis. Signals of death-receptors. Role of caspases in
apoptosis. Anti-apoptotic signals for cell survival – role of PI3K and PKB/Akt.
Regulation and clinical significance of programmed cell death.

(Signals of death-receptors. Role of caspases in apoptosis) (Apoptosis –


molecular mechanisms) (Anti-apoptotic signals for cell survival – role of PI3K
and PKB/Akt.)

) included in the scheme.

External Pathway of
Apoptosis

Apoptosis also known as programmed cell death, is


very important for the cells of the body. The cells of
the body need to be killed at a certain point to prevent
non stop growth, like cancer cells. Changes occur in
the cell once it has received its signal for death, these
changes include blebbing, cell shrinkage, nuclear frahmentation, chromatin
condensation and hromosomal DNA fragmentation.  

Intrinsic and extrinsic pathways of apoptosis

In the intrinsic pathway (mitochondrial mediated) the cell kills itself as it senses
cell stress. The cellular contents are degraded by capspases. After the cell has
been signalled the mitochondria releases cytochrome cinto the cytoplasm. This
then forms a apoptosome and causes the activation of the caspase cascade
through caspcase 9. Then activates caspase 3, capase cascade and then
apoptosis occurs.

In the extrinsic pathway (death receptor mediated) the cell is signalled by


other cells to die. The ligand binds to the death receptors. Bound to the
intracellular part of the receptor is procaspase 8 which due to the bind of the
ligand with the receptor releases as is caspase 8. A caspase cascade is activated
and then apoptosis occurs.

You might also like