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Examination Paper For MOL3020 Molecular Virology

This document provides information about an examination for a Molecular Virology course taken on December 19th, 2014. It outlines the academic contact for the exam, the time and location of the exam, and permitted materials. It then lists 4 exam questions, providing short descriptions of the topics and concepts covered in each question. The questions address viral glycoproteins, latency, retroviruses, vaccines, interferon production and function, viral structure and life cycles, viral replication mechanisms, viral receptors and entry, determinants of viral disease symptoms, differences between acute and persistent infections, and viral tropism.

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Mohamed Mounir
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97 views3 pages

Examination Paper For MOL3020 Molecular Virology

This document provides information about an examination for a Molecular Virology course taken on December 19th, 2014. It outlines the academic contact for the exam, the time and location of the exam, and permitted materials. It then lists 4 exam questions, providing short descriptions of the topics and concepts covered in each question. The questions address viral glycoproteins, latency, retroviruses, vaccines, interferon production and function, viral structure and life cycles, viral replication mechanisms, viral receptors and entry, determinants of viral disease symptoms, differences between acute and persistent infections, and viral tropism.

Uploaded by

Mohamed Mounir
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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Department of Laboratory Medicine, Children`s and Women`s Health (LBK), Faculty

of Medicine (DMF)

Examination paper for MOL3020 Molecular Virology

Academic contact during examination: Marit W. Anthonsen


Phone: 91897559, 72573351

Examination date: 19th of December, 2014


Examination time (from-to): 09:00 – 13:00
Permitted examination support material: D

Other information:

Language: English
Number of pages (including front page): 3
Number of pages enclosed:

Checked by:

____________________________
Date Signature

1
Short answers are expected; most questions can be answered with a few sentences, a
list or a drawing with explanatory comments

Examination question 1 (20 points)

In brief, explicate the following terms (use approx. 3-5 keywords and give relevant
examples):

a) Viral glycoproteins

b) Latency

c) Retrovirus

d) Vaccine

e) Interferon – Production and function

Examination question 2 (30 points)

a) What are the principal components of viruses?

b) What are the functions of the viral structural proteins?

c) Briefly describe the basic steps in the viral life cycle

d) Herpes- and adenoviruses are both viruses with linear double stranded DNA-
genomes, but their replication mechanisms differ considerably. Give step by step-
summaries of both mechanisms (you may use drawings). Note: the question refers to
replication mechanism and not life cycle.

Examination question 3 (20 points)

a) Mention some cell surface molecules used by animal viruses as receptors. What is
antibody-dependent enhancement of infectivity?

b) Describe the steps from extracellular viral particle to intracellular genome for an
animal virus. Highlight the difference in entry between enveloped and non-enveloped
viruses.

c) Describe in detail the fusion entry of the genome of an HIV-1 virion into a target cell.
How does the drug Enfuvirtide (T-20) inhibit this process?

2
Examination question 4 (30 points)

a) What determines the symptoms of viral infectious disease? Use examples from human
medicine.

b) Briefly explain the differences between acute and persistent viral infections on a
clinical and molecular level. Use examples.

c) What is meant by cell “tropism”? Which properties/aspects define the tropism of a


virus?

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