How to Administer Intramuscular and Subcutaneous
Vaccine Injections to Adults
Intramuscular (IM) Injections
Administer these vaccines via IM route
• Haemophilus influenzae type b (Hib)
• Hepatitis A (HepA)
• Hepatitis B (HepB)
• Human papillomavirus (HPV) acromion process
• Influenza vaccine, injectable (IIV) • (bony prominence above deltoid)
• Influenza vaccine, recombinant (RIV3; RIV4)
level of armpit
• Meningococcal conjugate (MenACWY) IM injection site
• Meningococcal serogroup B (MenB) (shaded area = deltoid muscle)
• Pneumococcal conjugate (PCV13)
• Pneumococcal polysaccharide (PPSV23) – elbow
may also be given Subcut
• Polio (IPV) – may also be given Subcut
• Tetanus, diphtheria (Td), or with pertussis (Tdap)
• Zoster, recombinant (RZV; Shingrix)
90° angle
Injection site
skin
Give in the central and thickest portion of the deltoid
muscle – above the level of the armpit and approximately subcutaneous tissue
2–3 fingerbreadths (~2") below the acromion process.
muscle
See the diagram. To avoid causing an injury, do not inject
too high (near the acromion process) or too low.
Note: A ⅝" needle is sufficient in adults weighing less than 130 lbs
Needle size
(<60 kg) for IM injection in the deltoid muscle only if the subcutane-
22–25 gauge, 1–1½" needle (see note at right) ous tissue is not bunched and the injection is made at a 90° angle;
Needle insertion a 1" needle is sufficient in adults weighing 130–152 lbs (60–70 kg);
a 1–1½" needle is recommended in women weighing 153–200 lbs
• Use a needle long enough to reach deep into the muscle.
(70–90 kg) and men weighing 153–260 lbs (70–118 kg); a 1½" needle
• Insert the needle at a 90° angle to the skin with a quick is recommended in women weighing more than 200 lbs (91 kg) or
thrust. men weighing more than 260 lbs (more than 118 kg).
• Separate two injections given in the same deltoid muscle
by a minimum of 1".
Subcutaneous (Subcut) Injections Administer these vaccines via Subcut route
• Measles, mumps, rubella (MMR)
• Pneumococcal polysaccharide (PPSV23) –
may also be given IM
• Polio (IPV) – may also be given IM
acromion process
• Varicella (Var; chickenpox)
• Zoster, live (ZVL; Zostavax)
Subcut injection site
Injection site
(shaded area)
Give in fatty tissue over the triceps. See the diagram.
elbow
Needle size
23–25 gauge, 5/8" needle
45° angle
Needle insertion
skin • Pinch up on the tissue to prevent injection into the
muscle. Insert the needle at a 45° angle to the skin.
subcutaneous tissue • Separate two injections given in the same area of fatty
muscle tissue by a minimum of 1".
Saint Paul, Minnesota • 651- 647- 9009 • www.immunize.org • www.vaccineinformation.org
www.immunize.org/catg.d/p2020a.pdf • Item #P2020a (1/18)