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Introduction Lecture

This document provides an introduction to biochemical engineering. It defines biochemical engineering as the design and construction of unit processes involving biological organisms or molecules by applying engineering principles to biological materials, processes, and systems. Biochemical engineers work in various sectors of the biotechnology industry, including pharmaceuticals, food, environment, and waste treatment. Their work involves fields like chemical engineering, biochemistry, biology and genetics. They are involved in diverse applications such as cell culture development, bioreactor design, bioseparations, process design and scale up. The document outlines essential knowledge and skills for biochemical engineering, including an understanding of cells, metabolism, enzymes, kinetics, reaction design and data analysis, separation processes, and industrial considerations.

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farmanrezavi
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37 views

Introduction Lecture

This document provides an introduction to biochemical engineering. It defines biochemical engineering as the design and construction of unit processes involving biological organisms or molecules by applying engineering principles to biological materials, processes, and systems. Biochemical engineers work in various sectors of the biotechnology industry, including pharmaceuticals, food, environment, and waste treatment. Their work involves fields like chemical engineering, biochemistry, biology and genetics. They are involved in diverse applications such as cell culture development, bioreactor design, bioseparations, process design and scale up. The document outlines essential knowledge and skills for biochemical engineering, including an understanding of cells, metabolism, enzymes, kinetics, reaction design and data analysis, separation processes, and industrial considerations.

Uploaded by

farmanrezavi
Copyright
© Attribution Non-Commercial (BY-NC)
Available Formats
Download as PDF, TXT or read online on Scribd
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Introduction to Biochemical

Engineering

Introduction
Joumana Zeid
• B.S. & M.S. Chemical Engineering (SJSU)
• Industry experience
– Membrane Technology and Research
– Genentech, Inc
Late Stage Purification, Process Development
[email protected]
Office Hours: Tue. Thur. 1915 – 2000

1
Introduction
What is Biochemical Engineering?
– Design and construction of unit processes
that involve biological organisms or molecules
– Apply engineering principles to biological
materials, processes, and systems
– Engineering and translation of discoveries in
Biochemistry and Medicine into commercial
processes for new biological entities

Introduction
What do biochemical engineers do?
– Typical employers come from all sectors of
the biotechnology industries, including those
with interests in pharmaceuticals, food,
environment, waste treatment, and consulting
• Specialties include
– Fermentations and reactors
– Purification processes
– Enzymes and kinetics

2
Introduction
• Fields combined and applied in chemical
engineering
– Chemical Engineering
– Biochemistry
– Biology
– Genetics

Introduction
• Diverse Applications
– Culture development
– Optimizing cell fermentations
– Bioreactor design
– Bioseparations
– Process design, optimization and intergration
– Process transfer to manufacturing scale
– Manufacturing and controls

3
Introduction
• Biotechnology
Acquiring biological knowledge to develop
new processes and products

• Industry sectors:
– Agriculture
– Resource management
– Health: Biopharmaceuticals

Introduction: Biotechnology application


• Applications: Process Design
Cell Culture
Ultrafiltration / Diafiltration
Harvest

Affinity Chromatography IEX or Hydrophobic


Interaction Chromatography

Viral Inactivation
Conditioning

Conditioning
Ion Exchange
Chromatography (IEX)

4
Introduction
• Essential Knowledge/ Topics
– Cells
– How cells work
– Metabolism Pathways
– Enzymes and Kinetics
– Reactors: Design and Data Analysis
– Bioseparations
– Application and Industrial considerations

Introduction
• Essential Skills
– COMMUNICATION
– Design of experiments
– Data Analysis
– Problem Solving and Troubleshooting

5
Class Information
Honesty Policy
• Students are expected to do their own work on
homework and exams and acknowledge the
contributions of their sources in the paper
presentation. Cases of academic dishonesty
will result in an F on the exam, and a note to
appropriate personnel on campus, including
your advisor for addition to your file, and
may result in an F in this course.
• Please review the SJSU Dishonesty policy as
that is followed in this course:
http://www.cob.sjsu.edu/bus91l/91L_univ_policy.htm

Class Information
Meeting: TuTh 6:00 – 7:15

Office hours: TuTh 7:15 – 8:00

Book
• Bioprocess Engineering 2nd Edition, Michael L.
Shuler and Fikret Kargi, Prentice-Hall

Prerequisites
• Bio 80 and Chem 112A, OR Chem 130AB, OR
Chem 135 OR ChE 158 (may be concurrent)

6
Class Information
Grade breakdown
– HW and Class Problems 20%
• Random questions can be graded
– 2 Midterms 30%
• Timing TBD
• Any quizzes will be included here
– Class Project
• Paper 15%
• Presentation 10%
– Final 25%
• Thursday December 13, 1715-1930

Class Project
• A review paper will be due in this class. The
topic must have applications in or involve
engineering, and should not be primarily
biological science oriented.
• The paper is an individual assignment.
• The content of the paper is to be a historical
development of a particular technology, followed
by a thorough description of the current status of
research in the area in including the future
direction(s).

7
Class Project: Timelines
• Topic selections September 20
– Chosen by individuals
• Literature Reviews October 1 8
– Paragraph description with 4-5 page literature
review
• Paper November 15
– Maximum 15 pages double spaced
• Presentations
– At the end of the semester
– Potentially 15 minutes each

Class Project
• To be completed in groups of 2

• You are responsible for finding a partner

• Team assignments by August 30


– Individuals without partners, let me know

8
Lecture Notes
• Most lecture notes will be in PowerPoint
slide-format

• E-mailed prior to lecture?


– Will need COMPLETE class e-mail list

• Course Website?
– http://www.engr.sjsu.edu/ChE192/

Genentech Tour
• Interest?

• Timing
– At beginning of bioseparations?

• Logistics?
– Transportation

No Guarantees!

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