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    Cefuroxime is an oral and injectable antibiotic used to treat a variety of bacterial infections including those of the respiratory tract, skin, urinary tract, bones, and joints. It is administered orally, intramuscularly, or intravenously depending on the infection. The dosage varies depending on the infection, age of the patient, and route of administration. Cefuroxime is generally well tolerated but can cause allergic reactions in patients with hypersensitivity to cephalosporin antibiotics.

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    Cefuroxime is an oral and injectable antibiotic used to treat a variety of bacterial infections including those of the respiratory tract, skin, urinary tract, bones, and joints. It is administered orally, intramuscularly, or intravenously depending on the infection. The dosage varies depending on the infection, age of the patient, and route of administration. Cefuroxime is generally well tolerated but can cause allergic reactions in patients with hypersensitivity to cephalosporin antibiotics.

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    Cefuroxime is an oral and injectable antibiotic used to treat a variety of bacterial infections including those of the respiratory tract, skin, urinary tract, bones, and joints. It is administered orally, intramuscularly, or intravenously depending on the infection. The dosage varies depending on the infection, age of the patient, and route of administration. Cefuroxime is generally well tolerated but can cause allergic reactions in patients with hypersensitivity to cephalosporin antibiotics.

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    Baxet

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    jtehdz22
    Cefuroxime is an oral and injectable antibiotic used to treat a variety of bacterial infections including those of the respiratory tract, skin, urinary tract, bones, and joints. It is administered orally, intramuscularly, or intravenously depending on the infection. The dosage varies depending on the infection, age of the patient, and route of administration. Cefuroxime is generally well tolerated but can cause allergic reactions in patients with hypersensitivity to cephalosporin antibiotics.

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    Cefuroxime Dosage and Administration

    Pronunciation: (SEFF-yur-OX-eem) Infection


    Class: Antibiotic, Cephalosporin Adults and Children 12 yr of age and older
    Trade Names: PO 125 to 500 mg twice daily. IV / IM 750 mg to 1.5 g every
    Ceftin 8 h.
    - Tablets 125 mg Children younger than 12 yr of age
    - Tablets 250 mg PO 125 to 250 mg twice daily.
    - Tablets 500 mg Infants and Children older than 3 mo of age
    - Suspension 125 mg/5 mL IV / IM 50 to 150 mg/kg/day (not to exceed adult dose) in
    - Suspension 250 mg/5 mL equally divided doses every 6 to 8 h.
    Trade Names: Bacterial Meningitis
    Zinacef Adults and Children 12 yr of age and older
    - Powder for Injection 750 mg (2.4 mEq sodium/g) IV / IM Up to 3 g every 8 h.
    - Powder for Injection 1.5 g (2.4 mEq sodium/g) Infants and Children 3 mo to 12 yr of age
    - Powder for Injection 7.5 g (2.4 mEq sodium/g) IV / IM 200 to 240 mg/kg/day in divided doses every 6 to 8 h.
    - Injection 750 mg (2.4 mEq sodium/g) Uncomplicated Gonorrhea
    - Injection 1.5 g (2.4 mEq sodium/g) Adults and Children 12 yr of age and older
    Apo-Cefuroxime (Canada) PO 1 g as single dose. IM 1.5 g as single dose.
    ratio-Cefuroxime (Canada) Preoperative Prophylaxis
    Adults
    Pharmacokinetics IV / IM 1.5 g 30 min to 1 h before surgery then 750 mg every
    Absorption 8 h for duration of surgery.
    Tablets General Advice
    C max is 2.1 mcg/mL (125 mg dose) to 13.6 mcg/mL (1,000 mg  Administer oral form with food to enhance
    dose). T max is 2.2 to 3 h. AUC is 6.7 mcg•h/mL (125 mg dose) absorption.
    to 50 mcg•h/mL (1,000 mg dose).  May crush and mix with food or beverages;
    Suspension (10 to 20 mg/kg) however, crushed tablets have strong, persistent bitter
    C max is 3.3 to 7 mcg/mL. T max is 2.7 to 3.6 h. AUC is 12.4 to taste. Consider alternative therapy if children cannot
    32.8 mcg•h/mL. swallow whole tablets.
    IM (750 mg dose)  Reconstituted solution should be light yellow to
    C max is 27 mcg/mL. T max is about 45 min. amber. Do not administer if solution is cloudy or
    IV precipitate is present.
    C max is about 50 mcg/mL (750 mg dose) and about 100  When giving by IM route, shake IM suspension
    mcg/mL (1.5 g dose). T max is 15 min. gently before administration. Aspirate to prevent
    Distribution injection into blood vessel. Inject deeply into large
    Cefuroxime is detectable in therapeutic concentrations in muscle (eg, upper outer quadrant of gluteus muscle or
    pleural and joint fluid, bile, sputum, bone, aqueous humor, and lateral thigh); massage well. Rotate injection sites.
    CSF (in those with meningitis). It is 50% protein bound.  When giving by IV route, use direct intermittent
    Elimination infusion. Administer slowly over 3 to 5 min. Change
    The t ½ is 1.2 to 1.3 h (tablets), 1.4 to 1.9 h (suspension), and IV sites every 48 to 72 h.
    about 80 min (IV/IM). About 50% is excreted unchanged in  For intermittent IV infusion with Y-type
    the urine within 12 h (tablets/suspension) and about 89% over administration set, administer over 30 min. and
    8 h (IV/IM). temporarily stop other solutions at Y-site.
    Special Populations  For continuous infusion, reconstituted solution
    Renal Function Impairment may be further diluted with D5W or sodium chloride
    The t ½ is prolonged. Dosage reduction is recommended. 0.9%.
    Indications and Usage Storage/Stability
    Oral form
     Reconstituted solution is stable for 24 h at room
    Treatment of infections of lower respiratory tract, urinary
    temperature. When refrigerated, solution in vials is
    tract, skin and skin structures; treatment of uncomplicated
    stable for 48 h; IV solution is stable for 7 days when
    gonorrhea, otitis media, pharyngitis, and tonsillitis caused by
    refrigerated.
    susceptible strains of specific microorganisms. Treatment of
     Completely thaw frozen solution at room
    early Lyme disease, pharyngitis/tonsillitis, and impetigo.
    temperature before use; do not refreeze.
    Parenteral form
    Treatment of infections of lower respiratory tract, urinary  Store sterile powder at room temperature and
    tract, skin and skin structures, bone and joint; preoperative protect from light.
    prophylaxis; treatment of septicemia, gonorrhea, and  Store tablets at room temperature.
    meningitis caused by susceptible strains of specific
    microorganisms.
    Contraindications
    Hypersensitivity to cephalosporins.

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