Hypothermia in Patients Resuscit A Nontraumatic Cardiac Arrest
Hypothermia in Patients Resuscit A Nontraumatic Cardiac Arrest
Hypothermia in Patients Resuscit A Nontraumatic Cardiac Arrest
APPROV AL: Chair, Critical Care Advisory Committee Assistant Administrator, Patient
Care Services
OBJECTIVE: To minimize hypoxic brain injury in patients recovering from in- or out-of-
hospital non-traumatic cardiac arrest
Background: Anoxic brain injury is a major source of morbidity and mortality after cardiac
arrest. However, there is a large body of experimental evidence and two
prospective, randomized clinical trials that suggest that mild-moderate
hypothermia protects the brain during global ischemia after primary non-
traumatic cardiac arrest (ventricular fibrillation), and leads to improved
neurologic outcome. (N Engl J Med 2002; 346:549-56, 557-63, 612-3). In
addition, the ACLS Guidelines (October, 2000) recommend the maintenance
of mild hypothermia (temperature >33°C) after cardiac arrest (level of
evidence Class lIb).
Indications: All comatose patients after VF jVT, PEA, or asystolic non-traumatic cardiac
arrests with no contraindications to mild hypothermia.
Specifics: The goal temperature for the first 24 hours post-resuscitation is a core body
temperature (esophageal) of 33°C. Specific recommendations for temperature
management are as follows:
• If no Polar Bair available use another Cooling Blanket (plugged into same machine) placed over
patient.
For patients with shivering and or agitation, meperidine and diazepam should be administered, with
consideration of neuromuscular blockade in refractory cases.
These guidelines can be applied by initiating the complementary order form entitled "Hypothermia
Protocol For Comatose Patients Resuscitated From Nontraumatic Cardiac Arrest", which includes
specific interventions and drug doses.
Version 5, 12/11/02