PHILIPPINE COLLEGE OF HEALTH SCIENCES

College of Pharmacy
PHARMACOLOGY 1

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CHAPTER TITLE: DATE:
INSTRUCTION: Please answer the following items based on Basic and Clinical Pharmacology by Bertam Katzung
DRUG NAME BRAND NAME MECHANISM OF ACTION THERAPEUTIC USE ADVERSE DRUG REACTION
LITHIUM • suppresses inositol signaling Bipolar affective disorder— Tremor, edema, hypothyroidism,
and inhibits glycogen synthase prophylactic use can renal dysfunction, dysrhythmias
kinase-3 (GSK-3), a prevent mood swings
multifunctional protein kinase between mania and
depression
Carbamazepine Tegretol is a sodium channel blocker. It acute mania and for diplopia and ataxia
binds preferentially to voltage- prophylaxis in depressive Hematotoxicity and induction of P450
gated sodium channels in their phase drug metabolism
inactive conformation, which
prevents repetitive and
sustained firing of
an action potential
Lamotrigine Lamictal alters Na + , K + , and Ca 2+ acute mania and for nausea, dizziness, and headache
conductance, membrane prophylaxis in depressive rash
potentials, and the phase
concentrations of amino acids
prolongation of—the inactivated
state of the Na + channel
Valproic acid Depakene potent inhibitor of histone Valproic acid is increasingly possible weight gain, alopecia
deacetylase and through this used as first choice in acute tremor, liver dysfunction, inhibition
mechanism changes the mania of drug metabolism
transcription of many genes.
promethazine Phenergan a phenothiazine derivative with anti-emetic and sedative Extrapyramidal symptoms
very weak dopamine receptor effects. Disorientation
antagonism, that also blocks
H1 receptors. Euphoria
Triflupromazine Vesprin binds to the dopamine D1 ffective phrenotropic  A Feeling Of
and dopamine D2 agent in many acute and Restlessness With Inability To
receptors inhibition  in chronic psychotic cases Sit Still.
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PHARMACOLOGY 1
the chemoreceptor  Blurred Vision.
trigger zone (CTZ) and  Extrapyramidal Disease,
vomiting centre.  A Type Of Movement Disorder.

melperone Buronil  antagonist activity at D2 For the treatment of Extrapyramidal Disease

dopaminergic and 5HT2A schizophrenia, sleep, gastrointestinal disturbance
serotonergic receptors disorders, agitation and
mentally confused states 
resembles clozapine
Molindone Moban blocks postsynaptic Indicated for the  dizziness.
dopaminergic receptors management of  drowsiness.
(D2) in the nucleus schizophrenia  depression.
accumbens, striatum,  restlessness.
and ventral tegmental
area; decreasing
dopamine activity
zotepine Losizopilon  Zotepine is an atypical antimanic agent in somnolence and weight gain
Lodopin  antipsychotic that is an patients with acute
Setous  antagonist at central dopamine bipolar mania.
(D1 and D2) receptors. It also And schizoprenia
binds to serotonin, adrenergic
(α1), and histamine (H1)
receptors, and inhibits
noradrenaline reuptake.
Zuclopenthixol Clopixol & Acuphase antagonism of D1 and D2 Management of NEUROLEPTIC MALIGNANT
dopamine schizophrenia SYNDROME
receptors. Zuclopenthixol also treatment of acute  THROMBOEMBOLISM
has high affinity for alpha1- psychotic episodes ardive dyskinesia, weakness
adrenergic and 5-HT2
receptors produces neuroleptic
activity
Flupenthixol Depixol and Fluanxol Powerful both D1 and D2 used for the long-term In preggy: shaking, muscle
dopamine receptors antagonist treatment of stiffness and/or weakness,
blocks postsynaptic dopamine schizophrenia sleepiness, agitation, breathing
receptors in the CNS.and problems and difficulty in feeding.
alpha-adrenergic receptor
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PHARMACOLOGY 1
antagonist
Perphenazine Trilafon d opamine antagonist with Anti emesis slow heart rate, weak pulse, weak
antiemetic or shallow breathing; fever, 
And tx for
blocks postsynaptic dopamine schizophrenia.
2(D2) receptors in the
mesolimbic and medullary
chemoreceptor trigger zone
(CTZ), thereby preventing the
excess of dopamine in the
brain.
Pimozide Orap selectively inhibits type 2 reduce uncontrolled 1) electrocardiographic
dopaminergic receptors in the movements (motor tics) abnormalities,
central nervous system (CNS), or outbursts of 2) severe extrapyramidal reactions,
thereby decreasing dopamine words/sounds (vocal tics) 3) hypotension,
neurotransmission and caused by Tourette 4) a comatose state with respiratory
reducing the occurrence of syndrome.  depression.
motor and vocal tics and
delusions of parasitosis. In
addition, this agent
antagonizes alpha-adrenergic
and 5-HT2 receptors
Prochlorperazine Compazine   Tx for severe N & V Drowsiness, dizziness,
dopamine blockade in amenorrhea, blurred vision, skin
reactions and hypotension
the chemoreceptor jaundice
trigger zone of the brain.
Asenapine () Saphris combination of antagonist treatment of somnolence, dizziness,
activity at D2 and 5-HT2A schizophrenia in adults, dysgeusia, oral
receptors as well as the treatment hypoesthesia, nausea, increased
of acute manic or mixed appetite, fatigue, and increased
episodes of bipolar weight.
Fluphenazine decanoate Prolixin blocking postsynaptic his medication is a long- Drowsines
dopamine D2 receptors in the acting form Dizziness
limbic, cortical system and of fluphenazine that is sweating, dry mouth
basal ganglia. used to treat certain
mental/mood problems
(chronic schizophren
Haloperidol ester Haldol Decanoate competitively blocks  treatment of extrapyramidal movement
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PHARMACOLOGY 1
postsynaptic dopamine schizophrenia, tics in disorders, especially
receptors in the mesolimbic Tourette syndrome, parkinsonism, acute dyskinesias,
dopaminergic system and and akathisia
increases turnover of brain
dopamine
Loxapine Loxitane blocking dopamine at Anti emetic dizziness, drowsiness, faintness
postsynaptic receptor sites in vomiting dry mouth
the brain.
Paliperidone Invega) antagonist and thus interferes schizoaffective disorder  drowsiness;
with neurotransmitter as monotherapy and an
communication in the brain. It adjunct to mood  nausea and vomiting
blocks dopamine type 2, stabilizers
serotonin type 2, and alpha 2
adrenergic receptors,
acetophenazine Acetophenazine blocks reatment of disorganized lurred vision, a dry mouth, tremors
postsynaptic mesolimbic and psychotic thinking. or uncontrollable shaking,
dopaminergic D1 and D2 depression
receptors in the brain;
depresses the release of
hypothalamic and hypophyseal
hormones 
Amisulpride Solian binds selectively to dopamine treat symptoms of  drowsiness.
D2, D3 receptors in the limbic schizophrenia and
system,  hallucination
 weight gain.
 dizziness.

Trifluoperazine blocking central dopamine antipsychotic and Drowsiness, dizziness fatigue

receptors antiemetic activities weakness
Geodon combination of dopamine type used to
Ziprasidone () 2 (D2) and serotonin type 2 treat schizophrenia and
(5HT2) antagonism. the manic symptoms of
bipolar disorder (manic
depression) in adults and
children 
Lithium carbonate,) Eskalith
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PHARMACOLOGY 1
Topiramate ( Topamax) blocks voltage-dependent used alone or with other
sodium and calcium channels. medications to prevent
It also inhibits the excitatory and control seizures
glutamate pathway while (epilepsy). This
enhancing the inhibitory effect medication is also used to
of GABA. prevent migraine
headaches and decrease
how often you get
them. Topiramate will not
treat a migraine
headache once it occurs.