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    (Lib-Ebooks Com) 030520200251

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    Daksh Malhotra
    MEDICINE VISUAL

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    (Lib-Ebooks Com) 030520200251

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    Daksh Malhotra
    14 views280 pages
    MEDICINE VISUAL

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    (Lib-Ebooks.com)030520200251 (2)

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    MEDICINE VISUAL

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    14 views280 pages

    (Lib-Ebooks Com) 030520200251

    Uploaded by

    Daksh Malhotra
    MEDICINE VISUAL

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
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    FDA approved drugs in 2019

    Tafamidis meglumine

    For the treatment of cardiomyopathy of wild type or hereditary transthyretin-mediated amyloidosis.

    Halobetasol propionate & Tazarotene

    For the treatment of plaque psoriasis

    PrabotulinumtoxinA – xvfs

    For the improvement of glabellar lines

    Risankizumab – rzaa

    For the treatment of plaque psoriasis

    Testosterone undecanoate

    For the treatment of male conditions associated with a deficiency or absence of endogenous
    testosterone

    Sumatriptan (nasal spray)

    For the treatment of acute migraine in adults,

    Antihemophilic factor (recombinant), glycopegylated – exei

    For the treatment of hemophilia A

    Caplacizumab – yhdp

    For the treatment of acquired thrombotic thrombocytopenic purpura


    Venetoclax + Obinutuzumab

    For the treatment of chronic lymphocytic leukemia or small lymphocytic lymphoma

    Ramucirumab

    For the treatment of hepatocellular carcinoma with elevated alpha-fetoprotein (AFP)

    Triclabendazole

    For the treatment of fascioliasis (liver fluke infestation)

    Immunoglobulin intravenous, Human – slra 10% liquid

    For the treatment of Primary Humoral Immunodeficiency Disease

    Dolutegravir and Lamivudine

    For the treatment of HIV-1 infection in adults

    Amifampridine

    For the treatment of Lambert-Eaton myasthenic syndrome in pediatrics

    Dengue tetravalent vaccine, Live

    For the prevention of dengue disease,

    Certolizumab pegol

    For the treatment of non-radiographic axial spondyloarthritis

    Romosozumab

    For the treatment of osteoporosis in postmenopausal women at high risk for fracture

    Cladribine

    For the treatment of relapsing multiple sclerosis


    Siponimod

    For the treatment of relapsing multiple sclerosis

    Midazolam

    For the treatment of intermittent, stereotypic episodes of frequent seizure activity

    Amifampridine

    For the treatment of Lambert-Eaton myasthenic syndrome in pediatrics

    Esketamine (nasal spray)

    For the treatment of treatment-resistant depression in adults

    Solriamfetol

    For the treatment of excessive daytime sleepiness due to narcolepsy or obstructive sleep apnea

    Trastuzumab & hyaluronidase – oysk

    For the treatment of HER2-overexpressing breast cancer

    Atezolizumab

    For the treatment of triple negative breast cancer


    For the treatment of extensive-stage small cell lung cancer

    Brexanolone

    For the treatment of postpartum depression

    Erdafitinib

    For the treatment of locally advanced or metastatic urothelial carcinoma

    Avelumab + axitinib
    For the first line treatment of advanced renal cell carcinoma

    Ramucirumab

    For the treatment of hepatocellular carcinoma with elevated alpha-fetoprotein (AFP)

    Pembrolizumab

    For the treatment of advanced renal cell carcinoma


    For the treatment of stage III non-small cell lung cancer

    Netarsudil & latanoprost ophthalmic solution

    For the treatment of elevated intraocular pressure in patients with open-angle glaucoma or ocular
    hypertension,

    Aclidinium bromide & Formoterol fumarate

    For the maintenance treatment of chronic obstructive pulmonary disease

    Solriamfetol

    For the treatment of excessive daytime sleepiness due to narcolepsy or obstructive sleep apnea

    FDA Approved drugs in 2017

    Voretigene Neparvovec

    AAV2 vector containing human RPE65 cDNA


    Subretinal injection
    Novel gene therapy for the treatment of Leber’s congenital amaurosis
    Leber’s congenital amaurosis, or biallelic RPE65 mediated inherited retinal
    disease, is an inherited disorder causing progressive blindness

    Netarsudil

    Rho kinase inhibitor


    Increase aqueous outflow
    Mechanism unknown
    Used in glaucoma

    Latanoprostene Bunod

    Metabolizes in the eye by esterases to Latanoprost and Butanediol


    mononitrate
    Butanediol mononitrate, an NO – donating moiety that is further metabolized
    to 1,4 – butanediol and NO
    NO increase trabecular outflow
    Latanoprost increase uveoscleral outflow
    Used in glaucoma

    Betrixaban

    Inhibitor of clotting factor Xa


    Used as anticoagulant

    Dupilumab

    It is a monoclonal antibody
    Used to treat Atopic dermatitis
    It acts against IL-4R alpha and inactivate IL-4 & IL-13

    Brodalumab, Guselkumab

    They are monoclonal antibodies


    Used in psoriasis
    Brodalumab is an antibody against IL-17
    Guselkumab is an antibody against IL-23

    Semaglutide

    Recombinant glucagon like peptide (GLP) analogs


    They can not be given orally, injectable drug
    Used in type II diabetes
    Etelcalcetide

    It is a calcium sensing receptor agonist


    Calcimimetic drug
    Used in hyper parathyroid induced osteoporosis

    Dapagliflozin, Ertugliflozin

    Blockers of SGLT-2 in PCT of kidney


    Increase glucose secretion in urine

    Plecanatide

    It stimulates guanylate cyclase C


    Approved for chronic idiopathic constipation

    Naldemedine

    Opioid antagonist (µ receptor antagonist)


    It is not absorbed from GIT
    It is used in opioid induced constipation

    Telotristat ethyl

    It inhibits the formation of serotonin


    It inhibits the enzyme tryptophan hydroxylase
    Approved for diarrhoea due to carcinoid syndrome

    Cerliponase alfa

    It is a recombinant Tripeptidyl peptidase – 1 enzyme


    It was approved for a lysosomal storage disease called infantile neuronal
    ceroid lipofuscinosis
    It is given by intracerebral ventricular injection

    Vestronidase alfa – VJBK


    Recombinant beta glucoronidase
    Approved for Mucopolysaccharidosis VII

    Inotuzumab ozogamicin

    Approved for Acute Lymphoid Leukemia (ALL)


    Inotuzumab is a monoclonal antibody against CD22
    Emicizumab KXWH

    Monoclonal antibody targeting the clotting factor IX & X


    Approved for treatment of haemophilia

    Glicaprevir / Pibrentasvir

    Approved for Hepatitis C


    Combination of protease inhibitor and NS5a inhibitor

    Tocilizumab

    Monoclonal antibody against IL-6


    Approved for the treatment of Rheumatoid arthritis and Cytokine release
    syndrome

    Letermovir

    Inhibit DNA terminase complex and inhibit the virus maturation


    Approved for CMV infection

    Lesinurad

    It inhibits URAT-1 transporter in kidney and increase uric acid secreation


    Approved for chronic gout

    Sarilumab

    Monoclonal antibody against IL-6


    Approved for the treatment of Rheumatoid arthritis
    Abaloparatide

    It is PTH1-34 molecule
    Used in osteoporosis by activating the osteoblasts
    Cannot be given orally

    Amantadine

    It is commonly used for Influenza and Parkinsonism


    It can block NMDA receptors and approved for levodopa induced dyskinesia

    Edaravone

    It is a free radical scavenger


    Approved for amyotrophic lateral sclerosis (ALS)

    Safinamide
    It is MAO-B inhibitor
    Approved in parkinsonism

    Ribociclib/Abemaciclib

    CDK-4 & 6 inhibitors


    Approved for cancer treatment (Breast cancer)

    Niraparib

    Inhibitor of poly ADP ribose polymerase enzyme


    Used in ovarian carcinoma

    Darvalumab

    Monoclonal antibodies against apoptosis ligands


    Used for bladder carcinoma (urothelial carcinoma)

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