BRO-ZEDEX RANGE Knowledge Express

Composition:

Bro Zedex – Terbutaline Sulphate 1.25mg + Bromhexine HCL 4 mg + Guaiphenesin 50 mg + Menthol

2.5mg/5ml

Bro Zedex SF - Terbutaline Sulphate 1.25mg + Bromhexine HCL 4 mg + Guaiphenesin 50 mg +

Menthol 2.5mg/5ml (Sugar Free Base of Sucralose)

Bro Zedex LS Kid: Levosalbutamol Sulphate 1 mg + Ambroxol HCL 30 mg + Guaiphenesin 50 mg +

mentholated base /5ml

Bro Zedex LS Plus: Levosalbutamol Sulphate 1 mg + Ambroxol HCL 30 mg + Guaiphenesin 50 mg +

Mentholated sugar free base /5ml (Sugar Free Base of Sucralose)

Brozedex LS drops: Levosalbutamol Sulphate 0.25 mg + Ambroxol HCL7.5mg + Guaiphenesin 12.5mg

/ml

Indication:

Composition Indication
Bro Zedex Productive Cough
Bro Zedex SF Productive Cough in Diabetic Patients
Bronchospastic Cough in Children associated with acute bronchitis and bronchial
Bro Zedex LS Kid asthma
Chronic Respiratory Conditions in elderly like COPD , Asthma , Bronchitis with co-
Bro Zedex LS+ morbidity
Wheezing and chest congestion in kids associated with bronchitis , bronchial
Brozedex LS drops asthma
Dose:

COMPOSITION / AGE GROUP &

SR.NO BRAND INDICATION/POSITIONING
5ml DOSING
Terbutaline
Sulphate 1.25mg + Adults -10ml 2-3
Bromhexine HCL 4 times/day
mg + Guaiphenesin Moderate-Severe 6-12 years 5 ml
1 Bro –Zedex
50 mg + Menthol Productive/Bronchospastic cough TID
3 – 6 years 2.5 ml
2.5mg/5ml
TID

2 to 6 years 2.5
ml BID
6 – 12 years:
start with 2.5
ml thrice daily
Levosalbutamol and increase to
Sulphate 1 mg + 5 ml of syrup 2-
Ambroxol HCL 30 3 times daily.
mg + Guaiphenesin Moderate-Severe
Brozedex LS
2 50 mg + Menthol Bronchospastic/Productive cough Adults (>12
kid
0.8 mg in kids
years) : 5ml
Expectorant/5ml
three times
daily. This may
be increased to
10 ml syrup
twice daily.

Adults (>12
years) : 5ml
Levosalbutamol
Sulphate 1 mg + three times
Ambroxol HCL 30 daily. This may
Chronic Respiratory Conditions in
Brozedex LS mg + Guaiphenesin
3 elderly like COPD , Asthma , be increased to
Plus 50 mg + Menthol
Bronchitis with co-morbidity
0.1 mg 10 ml syrup
Expectorant/5ml twice daily.
(Sugar Free Base)

Levosalbutamol Wheezing and chest congestion in 2ml three times

Brozedex LS
4 Sulphate 0.25 mg + kids associated with bronchitis , daily.
drops
Ambroxol bronchial asthma
 HCL7.5mg +
Guaiphenesin
12.5mg /ml

Key Message:
Bro-Zedex
 Nair Hospital Mumbai confirms that Brozedex is most viscous compared to other leading
brands.
 Bro Zedex is 100% more viscous compared to leading brands like Ascoril .
 Brozedex offers faster symptomatic relief in 30 mins
 Terbutaline in Brozedex relaxes airway muscles , improves pulmonary function & breathing
 Bromhexine in Brozedex is a mucolytic agent with antioxidant properties
 Guaiphenesin in Brozedex improves expectoration
 Menthol in Brozedex offers cooling soothing effect.
 Brozedex is celebrating 26 years of freedom to express in productive cough associated LRTI
and AECB
 Hence in productive cough Brozedex offers freedom from cough for last 26 years

Brozedex SF
 Studies have shown that cough syrups contain substantial amount of sugar. Department of
Clinical Pharmacology, Nair Hospital confirms, most commonly preferred brands like Asco,
Gri_Lt, Or Bro-Zit, contains on an average 3 tsp sugar per 30 ml of syrup (per day dose) ie 48
gram sugar / 100 ml of conventional cough syrup.
 Also conventional cough syrup contains 4 times more sugar then a cold drink ( 12 gm / 100
ml of sugar in cold drink versus 48 gm/ 100 ml of cough syrup ).
 Therefore in diabetic and hypertensive patients, when every spoon of sugar counts,
Brozedex SF is an ideal choice as it is available in sugar free form.

Bro Zedex LS Kid

 Brozedex LS Kid in Bronchospatic cough, is the 1st Levosalbutamol syrup with calibrated
patented spoon ie Brozedex LS Kid is exclusively designed to offer dosing convenience;
accuracy and contamination free dosing tool to help mothers which is alo published in the
form of CAPCON study in Indian Journal of Clinical Practise July 2015.
 Brozedex LS kid has 1 mg of levosalbutmol with better bronchodilation & safety profile
compared to salbutamol
 Brozedex LS kid reduces need of nebulization& concomitant medication and has 95% more
treatment satisfaction rates compared to salbutamol
  Brozedex LS kid formulation is DCGI approved with patented calibrated spoon that provides
hygienic and accurate dosing to your patients

Bro Zedex LS+

• In chronic respiratory condition like Asthma , Bronchitis , COPD recommend
Brozedex L S Plus which is the only sugar free form of Levosalbutamol
combination available in India
• Brozedex LS Plus offers superior tolerability and safety compared to Salbutamol
• Brozedex LS Plus is an effective bronchodilator compared to Salbutamol
• Brozedex LS Plus formulation is DCGI approved with sugar free form , yet sweet
to taste .
• RX Brozedex LS Plus that offers sugar free safety , superior tolerability and
efficacy of levosalbutamol combination in chronic respiratory condition like
Asthma , Bronchitis , COPD

Brozedex LS drops
 Wheezing & chest congestion limits the expression of childhood, Brozedex LS drops offers
cough relief for lasting smiles
 Brozedex LS drops has 0.25 mg of levosalbutmol with better bronchodilation & safety
profile compared to salbutamol
 7.5mg of Ambroxol in Brozedex LS drops reduces sputum volume & viscosity
 12.5 mg Guaiphenesin in Brozedex LS drops improves expectoration
 Brozedex LS drops comes along with a scientifically calibrated dropper for dosage accuracy .
Calibration in dropper of Brozedex LS drops starts from 0.1 ml to 1 ml .
 Rx Brozedex LS drops for cough relief with lasting smiles
Ingredient Pedia dose Adult dose Reference

Guaiphenesin 2-6 years: 50 to 100 mg 12 years & above: 200 to Micromedex.

orally every 4 hours; 400 mg orally every 4
maximum 600 mg/day hours; maximum 2400 Along with
mg/day terbutaline /
6-12 years: 100 to 200
levosalbutamol
mg orally every 4 hours;
maximum 1200 mg/day
the Guaiphenesin
requirement can
correspondingly
be reduced.

Terbutaline 2.5 to 5 mg ORALLY every

6 hr 3 times daily, MAX 15
mg/day

Levosalbutamol 50% of Salbutamol 50% of Salbutamol dosage As per text book

dosage given 2 to 3 times daily. Drug Dosages in
Children, 8th ED
0.05 mg to 0.2mg/kg/dose ;Meharban Singh
every 8 hour oral and Asok Deorari

Bromhexine 2-4 mg three times daily 8 to 16 milligrams orally Micromedex

below 5 years of age three times daily.

4 mg twice daily for 30 milligrams twice

children under 5 years of daily alternatively
age

4 mg four times daily for

children 5 to 10 years of
age

Ambroxol Up to 2 years - 15 Oral adult doses of 60 to Micromedex

milligrams (mg) daily; 180 milligrams/day in 2 or
3 divided doses. Average Many doctors
2 to 5 years - 15 to 30 120 mg/day. feel that the
mg daily;
dosing of
5 to 12 years - 30 to 45 Ambroxol in this
mg daily combination is on
the higher side
12 years and older - 60
to 90 mg daily but as children
are poor at
expectorating
sputum,
additional
 mucolytic
support and
dosing strength is
now being widely
accepted instead
of a higher dosing
strength of
expectorant.

Competitor Knock out points :

Sr Brand Company Knock out point

no

1 Ascoril Glenmark - Sub therapeutic dose of Bromhexine of 2 mg /

5ml leads to compromised results.

- Micromedex recommends 8 to 16 mg TID of

Bromhexine in adults and

- 4 mg twice daily for children under 5 years of

age

- Menthol is only 0.5 mg / 5ml this may not lead

to cooling soothing effect

- Viscosity of Ascoril is only 50.55centipoise

compared to 144 centipoise of Brozedex

2 Ascoril LS Glenmark - Very poor taste leads to non-compliance in

Little ones
- Conventional method of dosage
administration with caps leads to
unhygienic and inaccurate dosing in little
patients and is proven in CAPCON study
publishes in IJCP ( Indian Journal of Clinical
Practice )July 2015
3 Brozeet LS Alembic - 0.5 mg of Levosalbutamol is not approved
by DCGI
- Pineapple flavor has lot of after taste which
leads to poor patient compliance
4 Brozeet LS Plus Alembic - Very poor taste leads to non-compliance in
patients
- Does not have sugar free formulae as 48 gm
of sugar is there / 100 ml which may add
complication in patients with co-morbidities
associated with Asthma , COPD & Bronchitis
5 Kufril LS drops Med - Does not have accurately calibrated
manor dropper ; calibration starts with 0.25 mg
which may lead to inaccuracy of dosage
administration
6 Kofarest PD Centaur - Does not have accurately calibrated
drops dropper ; calibration is not visible clearly
which may mislead the patients / care
takers

Pack/ MRP / NSV and Competition

Sr. Name of the MRP in NSV in Competitor

No SKU Rs. Rs. Pack brand Company
100 ml
1 Brozedex 82 58.57 bottle Ascoril Glenmark
Brozeet Alembic
Macberry XT Macleods
Soventus Emcure
Tus Q X Blue cross
100 ml
2 Brozedex SF 78.5 56.07 bottle Ascoril SF Glenmark
Brozeet SF Alembic
60 ml
3 Brozedex LS kid 74.5 53.21 bottle Ascoril LS Glenmark
Brozeet LS Alembic
Macberry Junior Macleods
Chericof LS Sun
Kufril LS Med manor
100 ml
4 Brozedex LS Plus 88 60.34 bottle Ascoril LS Glenmark
Brozeet LS Plus Alembic
Macberry LS Macleods
Chericof LS Sun
Kufril LS Med manor
15 ml
5 Brozedex LS drops 41 28.56 bottle Ascoril LS drops Glenmark
Kufril LS drops Med manor
Kofarest PD drops Centaur