SLE Notes PDF

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MULTI SYSTEM DISORDER

320013 t ORGANS

AUTO -

Ab t

Type 2 HR Type 3 HR

RISK FACTORS

→ A
> > o
e,

reproductive age group
7 Pre reproductive g postmenopausal age groups
→ DIE female hormones


HLA DQ
.


Uv RAYS


DRUGS [ SULFONAMIDES ]


INFECTIONS ( septicemia C
Neutrophil Extracellular traps ])

→ f- ]
COMPLEMENT PROTEIN DEFICIENCY C
, /Cz/C4

CRITERIA FOR DIAGNOSIS

M

Malar Rash

D →
Discoid Rash

s → serositis

O

oral ulcers


A Arthritis


p photosensitivity

B →
Blood cells destruction by Auto Db

R →
Renal Involvement


A ANA C Anti Nuclear Ab ]

I Immunological leading

defects to other Ab

N

Neurological manifestations [ Epilepsy a psychosis ]


I 4 Out of II → SLE


Oral cavity involvement → Painless ulcers

→ →
Joints involvements Non erosive Arthritis

→ Butterfly Rash

Skin involvement BUTTER FLY RASH

[ Tin intensity on ox rays exposure ]


pulmonary involvement →
neuritis C more common )

SHRINKING LUNG SYNDROME

I dit weakness of
diaphragm ]

KIDNEY INVOLVEMENT

Diffuse

Type II Glomerulonephritis I proliferative Glomerulonephritis

glomerulonephritis

sub of
me type
postman

→ LOOP LESIONS
WIRE -

Seen

mugham
Depositions mom
mpmaw.am
www.mrhy
Blood human Mms www.
vessels


CARDIAC INVOLVEMENT

pericarditis [ ]

ENDOCARDITIS
→ common


Endocarditis → more LIBMAN SACK [ LSE → SHE ]

. Lower OF Mitral Endocardium
surface
valve [ ] involved more


SPLEEN INVOLVEMENT


ONION SKIN APPEARANCE in Blood vessels seen

→ reactions
die to immune complexes onionskin
appearance

AUTO ANTIBODIES
Libman sack
Endocarditis
I ANTI NUCLEAR ANTIBODIES →
most Sensitive Test For D ,

}
2 ANTI SMITH ANTIBODIES
most Specific Test For DX
3 DS ANTIBODIES
ANTI DNA
-


4 ANTI
-

120 ANTIBODY QIW Neonatal lupus



high risk For congenital Heart Block


alw subacute cutaneous
lupus

5 ANTI -
°
ANTIBODY

alw Psychosis
6 ANTI Glycoprotein Ab
132
-

→ seen C Reproductive ]
in q age group

presents I Recurrent Abortion


induces thrombotic state
pro

predisposed to
-

DVT E Deep vein thrombosis ]

I thrombosis ]
Hut Hepatic vein

stroke


aka ANTI PHOSPHOLIPID ANTIBODIES I APLA ]

responsible For APLA SYNDROME


-

IO

20 may alw SLE


-

APLA


causes Tapti [ in vitro I

→ reacts I CARDIOLIPIN Antigen

responsible for False Positive VDRL


-

DRVVT [ DILUTE RUSSEL VIPER VENOM TEST ]




detects auto Ab more specifically
.

LE

CELL Seen in SLE

Neutrophil I Macrophage I
damaged cell in it


present in vitro

LE CELL

TREATMENT

STEROIDS


DRUGS RESPONSIBLE :

S

SULFONAMIDES ( DAPSONE ]


It HYDRALAZINE


I ISONIAZID E


p PROCDINAMIDE


HIO drug intake tht


involved
NO Kidney I Brain


ANTI HISTONE ANTIBODIES tht

→ HLA
alw DR 4

TILA DRG


Offending

TREATMENT Withdrawal of
drug

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