SLE Notes PDF
SLE Notes PDF
SLE Notes PDF
320013 t ORGANS
AUTO -
Ab t
Type 2 HR Type 3 HR
RISK FACTORS
→ A
> > o
e,
→
reproductive age group
7 Pre reproductive g postmenopausal age groups
→ DIE female hormones
→
HLA DQ
.
→
Uv RAYS
→
DRUGS [ SULFONAMIDES ]
→
INFECTIONS ( septicemia C
Neutrophil Extracellular traps ])
→ f- ]
COMPLEMENT PROTEIN DEFICIENCY C
, /Cz/C4
M
→
Malar Rash
D →
Discoid Rash
s → serositis
O
→
oral ulcers
→
A Arthritis
→
p photosensitivity
B →
Blood cells destruction by Auto Db
R →
Renal Involvement
→
A ANA C Anti Nuclear Ab ]
I Immunological leading
→
defects to other Ab
N
→
Neurological manifestations [ Epilepsy a psychosis ]
→
I 4 Out of II → SLE
→
Oral cavity involvement → Painless ulcers
→ →
Joints involvements Non erosive Arthritis
→ Butterfly Rash
→
Skin involvement BUTTER FLY RASH
→
pulmonary involvement →
neuritis C more common )
I dit weakness of
diaphragm ]
→
KIDNEY INVOLVEMENT
Diffuse
→
Type II Glomerulonephritis I proliferative Glomerulonephritis
glomerulonephritis
→
sub of
me type
postman
→ LOOP LESIONS
WIRE -
Seen
mugham
Depositions mom
mpmaw.am
www.mrhy
Blood human Mms www.
vessels
→
CARDIAC INVOLVEMENT
pericarditis [ ]
ENDOCARDITIS
→ common
→
Endocarditis → more LIBMAN SACK [ LSE → SHE ]
→
. Lower OF Mitral Endocardium
surface
valve [ ] involved more
→
SPLEEN INVOLVEMENT
→
ONION SKIN APPEARANCE in Blood vessels seen
→ reactions
die to immune complexes onionskin
appearance
AUTO ANTIBODIES
Libman sack
Endocarditis
I ANTI NUCLEAR ANTIBODIES →
most Sensitive Test For D ,
}
2 ANTI SMITH ANTIBODIES
most Specific Test For DX
3 DS ANTIBODIES
ANTI DNA
-
→
4 ANTI
-
→
alw subacute cutaneous
lupus
5 ANTI -
°
ANTIBODY
→
alw Psychosis
6 ANTI Glycoprotein Ab
132
-
→ seen C Reproductive ]
in q age group
→
presents I Recurrent Abortion
→
induces thrombotic state
pro
predisposed to
-
I thrombosis ]
Hut Hepatic vein
stroke
→
aka ANTI PHOSPHOLIPID ANTIBODIES I APLA ]
IO
APLA
→
causes Tapti [ in vitro I
LE
→
CELL Seen in SLE
→
Neutrophil I Macrophage I
damaged cell in it
→
present in vitro
LE CELL
TREATMENT
→
STEROIDS
→
DRUGS RESPONSIBLE :
S
→
SULFONAMIDES ( DAPSONE ]
→
It HYDRALAZINE
→
I ISONIAZID E
→
p PROCDINAMIDE
→
HIO drug intake tht
→
involved
NO Kidney I Brain
→
ANTI HISTONE ANTIBODIES tht
→ HLA
alw DR 4
TILA DRG
→
Offending
→
TREATMENT Withdrawal of
drug