6.

11 WETTABLE POWDERS (WP)

Note for preparation of draft specifications. Do not omit clauses or insert additional clauses, nor
insert limits that are more lax than those than given in the guidelines, without referring to section
4. From the “Notes” provided at the end of this guideline, incorporate only those which are
applicable to the particular specification.

...... [ISO common name] WETTABLE POWDER

[CIPAC number]/WP (month & year of publication)

6.11.1 Description
The material shall consist of an homogeneous mixture of technical ...... [ISO common
name], complying with the requirements of FAO/WHO specification [......], in the form of
...... (see Section 4.2), together with filler(s) and any other necessary formulants. It shall
be in the form of a fine powder free from visible extraneous matter and hard lumps.

6.11.2 Active ingredient

6.11.2.1 Identity tests (Note 1)
The active ingredient shall comply with an identity test and, where the
identity remains in doubt, shall comply with at least one additional test.
6.11.2.2 ...... [ISO common name] content (Note 1)
The ...... [ISO common name] content shall be declared (g/kg) and, when
determined, the average content measured shall not differ from that
declared by more than the appropriate tolerance, given in the table of
tolerances, Section 4.3.2.

6.11.3 Relevant impurities

6.11.3.1 By-products of manufacture or storage (Note 2), if required
Maximum: ......% of the …… [ISO common name] content found under
6.11.2.2
6.11.3.2 Water (MT 30.5), if required
Maximum: ...... g/kg.

6.11.4 Physical properties

6.11.4.1 Acidity and/or Alkalinity (MT 191) or pH range (MT 75.3) (Note 3), if
required
Maximum acidity: ...... g/kg calculated as H2SO4.
Maximum alkalinity: ...... g/kg calculated as NaOH.
 pH range: ...... to ......
6.11.4.2 Wet sieve test (MT 185)
Maximum: ......% retained on a 75 µm test sieve.
6.11.4.3 Suspensibility (MT 184) (Note 4)
A minimum of ......% of the ...... [ISO common name] content found under
6.11.2.2 shall be in suspension after 30 min in CIPAC Standard Water D
at 30 ± 2 °C (Notes 5 & 6).

6.11.4.4 Persistent foam (MT 47.3) (Note 7)

Maximum: ...... ml after 1 min.
6.11.4.5 Wettability (MT 53.3)
The formulation shall be completely wetted in ...... min without swirling.

6.11.5 Storage stability

6.11.5.1 Stability at elevated temperature (MT 46.3)
After storage at 54 ± 2 °C for 14 days (Note 8), the determined average
active ingredient content must not be lower than ......% relative to the
determined average content found before storage (Note 9) and the
formulation shall continue to comply with the clauses for:
- by-products of manufacture or storage (6.11.3.1),
- acidity/alkalinity/pH range (6.11.4.1),
- wet sieve test (6.11.4.2),
- suspensibility (6.11.4.3),
- wettability (6.11.4.5),
as required.

________________________
Note 1 Method(s) of analysis must be CIPAC, AOAC or equivalent. If the methods have not yet been
published then full details, with appropriate method validation data, must be submitted to
FAO/WHO by the proposer.
Note 2 This clause should include only relevant impurities and the title should be changed to reflect the
name of the relevant impurity. Method(s) of analysis must be peer validated.
Note 3 The method to be used shall be stated. If several methods are available, a referee method shall
be selected.
Note 4 The formulation should be tested at the highest and lowest rates of use recommended by the
supplier, provided this does not exceed the conditions given in method MT 184.
Note 5 Unless another temperature is specified.
Note 6 Chemical assay is the only fully reliable method to measure the mass of active ingredient still in
suspension. However, simpler methods such as gravimetric and solvent extraction
 determination may be used on a routine basis provided that these methods have been shown
to give equal results to those of chemical assay. In case of dispute, chemical assay shall be the
“referee method”.
Note 7 The mass of sample to be used in the test should be at the highest rate of use recommended
by the supplier. The test is to be conducted in CIPAC standard water D.
Note 8 Unless other temperatures and/or times are specified. Refer to Section 4.6.2 of this Manual for
alternative storage conditions.
Note 9 Samples of the formulation taken before and after the storage stability test may be analyzed
concurrently after the test in order to reduce the analytical error.
WETTABLE POWDERS IN SEALED WATER SOLUBLE BAG (WP-SB)

Introduction
Note for preparation of draft specifications. Do not omit clauses or insert additional clauses, nor
insert limits that are more lax than those than given in the guidelines, without referring to section
4. From the “Notes” provided at the end of this guideline, incorporate only those which are
applicable to the particular specification.

…… [ISO common name] WETTABLE POWDER

IN SEALED WATER SOLUBLE BAG
(CIPAC Number)/WP-SB (month & year of publication)

6.12.1 Description
The material shall consist of a defined quantity of a homogeneous mixture of
technical ...... [ISO common name], complying with the requirements of the FAO/WHO
……, in the form of …… (see section 4.2) together with filler(s) and any other necessary
formulants. It shall be in the form of a fine powder, free from visible extraneous matter
and hard lumps, contained in a sealed water soluble bag (Note 1).

6.12.2 Active ingredient

6.12.2.1 Identity tests (Notes 2 & 3)
The active ingredient shall comply with an identity test and, where the identity remains
in doubt, shall comply with at least one additional test.
6.12.2.2 ...... [ISO common name] content (Note 2 & 3)
The ...... [ISO common name] content shall be declared (g/kg) and, when determined,
the average content measured shall not differ from that declared by more than the
appropriate tolerance, given in the table of tolerances, Section 4.3.2.

6.12.3 Relevant impurities (Note 2)

6.12.3.1 By-products of manufacture or storage (Note 4), if required
Maximum: ......% of the …… [ISO common name] content found under 2.2.
6.12.3.2 Water (MT 30.5) (Notes 5), if required
Maximum: ...... g/kg.
6.12.4 Physical properties (Note 2)
6.12.4.1 Acidity and/or Alkalinity (MT 191) or pH range (MT 75.3) (Note 5),
if required
Maximum acidity: ...... g/kg calculated as H2SO4.
Maximum alkalinity: ...... g/kg calculated as NaOH.
pH range: ...... to ......
6.12.4.2 Wettability (MT 53.3)
The formulation shall be completely wetted in ...... min without swirling.
6.12.4.3 Wet sieve test (MT 185)
Maximum: ......% retained on a 75 µm test sieve.
6.12.4.4 Suspensibility (MT 184) (Notes 6 & 7)
The suspensibility shall be tested on a suspension containing the WP and the
bag material in the actual ratio of application, prepared according to the
procedure described in Note 8.
A minimum of ......% shall be in suspension after 30 min in CIPAC Standard
Water D at 30 ± 2 °C (Note 9).
6.12.4.5 Persistent foam (MT 47.3) (Note 10 & 11)
The persistent foam shall be tested on a suspension containing the WP and the
bag material in the actual ratio of application in CIPAC Standard Water D,
prepared according to the procedure described in Note 8.
Maximum: …… ml after 1 min.
6.12.4.6 Dissolution of the bag (MT 176) (Notes 2 & 12)
The dissolution of the bag shall be tested on a sample of the emptied and
cleaned bag together with an appropriate proportion of the WP in CIPAC
Standard Water D taken according to the procedure described in Note 8.
Flow time of the suspension: maximum …… sec.

6.12.5 Storage stability

6.12.5.1 Stability at elevated temperature (MT 46.3)

The package should be enclosed in a watertight sachet, box or any other
container at 54 °C for 14 days (Note 13 & 14). The determined average active
ingredient content must not be lower than ……% relative to the determined
average content found before storage (Note 15) and the formulation shall
continue to comply with the clauses for:
- by-products of manufacture or storage (3.1),
- acidity/alkalinity/pH range (4.1),
 - wettability (4.2),
- wet sieve test (4.3),
- suspensibility (4.4),
- persistent foam (4.5),
- dissolution of the bag (4.6),
as required.

None of the bags tested should show signs of leakage or rupture during normal
handling, before and after storage.

Note 1 For record keeping purposes, the suffix “SB” should be added to the formulation code (WP-SB).
Note 2 Sub-sampling.
Lay the bag on a bench and carefully open one side of the bag with a cutter, taking care not to
damage the seals. Transfer the contents of the bag into a suitable flask. This material shall be
used to carry out the tests for:
- active ingredient identity (2.1),
- active ingredient content (2.2),
- by-products of manufacture or storage (3.1),
- water content (3.2),
- acidity/alkalinity/pH range (4.1),
- wettability (4.2),
- wet sieve test (4.3),
- suspensibility (4.4),
- persistent foam (4.5),
- dissolution of the bag (4.6).
The bag is then opened on three sides, completely cleaned from adhering powder by brushing
or suction and weighed to the nearest 0.01 g. It shall be used to carry out the dissolution test
(4.6). Aliquots of an aqueous solution of the bag material shall be used in the suspensibility
(4.4) and persistent foam (4.5) tests.
In the case of delay of the above tests, the bag shall be stored in a watertight container (glass
bottle or equivalent) to avoid any change in its properties.
Note 3 Method(s) of analysis must be CIPAC, AOAC or equivalent. If the methods have not yet been
published then full details, with appropriate method validation data, must be submitted to
FAO/WHO by the proposer.
Note 4 This clause should include only relevant impurities and the title should be changed to reflect the
name of the relevant impurity. Method(s) of analysis must be peer validated.
Note 5 The method to be used shall be stated. If several methods are available, a referee method shall
be selected.
Note 6 The formulation should be tested at the highest and lowest rates of use recommended by the
supplier, provided this does not exceed the conditions given in method MT 184.
Note 7 Chemical assay is the only fully reliable method to measure the mass of active ingredient still in
suspension. However, simpler methods such as gravimetric and solvent extraction
determination may be used on a routine basis provided that these methods have been shown
to give equal results to those of chemical assay. In case of dispute, chemical assay shall be the
“referee method”.
Note 8 The procedure for adding the bag material to the solution for the suspensibility and persistent
foam tests should be as follows:
 Prepare a stock solution of the bag material (1 mg/ml) by weighing approximately a sample (n
mg) of the bag (excluding sealed parts) to the nearest mg. Dissolve this sample by stirring in the
standard water used for the tests to give a final volume of n ml. Store the stock solution in a
stoppered bottle before use.
Calculate the volume (V ml) of the stock solution of the bag to be added to the test suspension
of the water dispersible granule according to the following equation:

V(ml) = X x 1000B
W
Where: B (g) = weight of the emptied and cleaned bag
W (g) = nominal weight of the WP contained in the bag
X (g) = weight of the WP sample used in the test
Note 9 Unless another temperature is specified.
Note 10 The mass of sample to be used in the test should be specified at the highest rate
recommended by the supplier. The test is to be conducted in CIPAC standard water D.
Note 11 The CIPAC method MT 47.2 published in Handbook F for determination of persistent foam created when
formulations are added to water before use was updated to MT 47.3. This new method was accepted as a full
CIPAC method in 2013. Prior to the publication in a Handbook, copies of the method may be obtained through the
CIPAC website, http://www.cipac.org/index.php/methods-publications/pre-published-methods
Note 12 The sampling of the bag for the dissolution test should be as follows:
Lay the empty cleaned bag in its original configuration (double layer). Delineate and then cut up
a test sample including part of the upper seal (5 cm) and symmetrically including the vertical
seal (10 cm). If the size of the bag is less than this dimension, use the whole bag.
Carry out the dissolution test immediately to avoid any modification of the sample.
Note 13 Unless other temperatures and/or times are specified. Refer to Section 4.6.2 of this Manual for
alternative storage conditions.
Note 14 If irreversible changes in the characteristics of the bag material are known to occur when stored
at elevated temperatures, refer to Section 4.6.2 of this Manual for alternative storage
conditions.
Note 15 Samples of the formulation taken before and after the storage stability test should be analyzed
concurrently after the test in order to reduce the analytical error.