CTR 2006 PDF
CTR 2006 PDF
CTR 2006 PDF
The CTR is manufactured by both Morcher GmbH With regards to the issue of IOL tilt and decentration,
(Stuttgart, Germany) and Ophtec (Groningen, The Lee et al. [17] reported their findings on 40 eyes of 20
Netherlands), and are US Food and Drug Administra- patients who were followed for 2 months. Each patient
tion (FDA) approved. The Morcher ring, also known had an IOL in one eye and an IOL with a CTR in the
as the Reform ring, comes in three different sizes fellow eye. Comparatively, the IOL-CTR group had a
based on an uncompressed diameter: 12.3 mm (com- statistically lower rate of IOL decentration compared
presses to 10.0 mm), 13.0 mm (compresses to with the IOL-only group using Scheimpflug image ana-
11.0 mm) and 14.5 mm (compresses to 12.0 mm). The lysis. The mean decentration in the IOL-CTR group
Ophtec ring (which is marketed as StabilEyes in the was 0.42 ± 0.17 mm, whereas in the IOL-only group it
United States by Advanced Medical Optics, Irvine, was 0.57 ± 0.16 mm. The amount of IOL tilt at 60 days
California) is available in a 13-mm ring (compresses to was also significantly less in the IOL-CTR group (IOL-
11 mm) and a 12.0-mm ring (compresses to 10.0 mm). CTR 2.47 ± 0.40˚, IOL-only 3.06 ± 0.56˚).
The CTR may be inserted manually with forceps or
with injectors (authors’ preference), which are less trau- Selection of capsular tension ring size
matic. Both Ophtec and Geuder (Heidelberg, Germany) The selection of CTR size is based on capsular bag
manufacture injectors that may be used to implant the dimensions. A larger capsular bag usually requires a lar-
Morcher and Ophtec CTRs. It is important to note that ger ring. Many surgeons prefer to choose a slightly larger
the Ophtec CTRs are not compatible with the Geuder implant, with 13 mm being most common. At minimum,
injector. Both the Morcher and Ophtec CTRs, however, overlap of the end terminals is needed to provide com-
may be used with Ophtec injector. plete circumferential support. Vass et al. have shown that
the size of the capsular bag positively correlates with the
Currently, few studies exist examining the safety and globe’s axial length [18]. The corneal diameter is also an
efficacy of CTRs. In a prospective study of 21 eyes, indicator of capsular bag size [18]. On the basis of this
Jacob et al. [1] evaluated the safety and efficacy of the information, white-to-white corneal measurement and
CTR in patients with less than 150˚ of zonular dialysis. axial measurements can be used as a guide to CTR siz-
The mean follow-up time was 242.33 days. They found ing, although many surgeons advocate routinely using
34 Cataract surgery and lens implantation
larger sizes (authors’ preference) to ensure adequate Table 2 Key points about the CTR
overlap of end terminals. Furthermore, it would be
When to use a CTR When not to use a CTR
appropriate to use a larger CTR in cataract surgery
involving highly myopic eyes [18]. Mild zonular weakness: Anterior capsule tear.
less than 4 clock hours of dia- Posterior capsule rent.
lysis; Incomplete rhexis.
Modified capsular tension ring mild generalized instability. Severely subluxed capsular bag.
All pseudoexfoliation patients (de-
Prior to the advent of the M-CTR, management of pro- bated): does improve centration
found lens subluxation required more invasive and com- and tilt.
plicated surgery as the standard CTR is unable to pro-
vide adequate intraoperative support and center the
capsule bag in these cases. Some surgeons sutured the
standard CTR through the capsule bag with or without a 1-L or 1-R) or two (model 2-L) fixation eyelets attached
peripheral capsulorhexis and then lassoed the CTR to the central ring. The eyelets, which allow the ring to
along with the peripheral capsule [19]. To avoid the be sutured to the sclera, protrude 0.25 mm forward from
risk of creating capsular tears with this technique, the body of the CTR and thus sit anterior to the anterior
Cionni developed the M-CTR (Morcher GmbH) in capsule, thereby conserving the capsular bag’s integrity
1998 (Fig. 3, Table 2). This implant provides a solution on suturing [6].
to extensive and/or progressive zonular damage by
allowing the surgeon to anchor the capsule bag to the Moreover, an adequately sized capsulorhexis (that is,
eye wall. It is an open-ring design with one (model 5.5 mm) is of utmost importance when working with
the M-CTR. In cases of a small capsulorhexis margin,
the hook may drag on the capsulorhexis edge and result
Figure 3 Cionni M-CTR for suture scleral fixation
in iris chafing and related pigment dispersion and
chronic uveitis.
In their case series of seven eyes (five patients), Capsular tension segment
Moreno-Montanes et al. [22] demonstrated that The CTS, designed by Ahmed in 2002 (Figs 4a–d) and
M-CTR implantation was an acceptable procedure to manufactured by Morcher GmbH, is also intended for
correct limited lens subluxation, with preservation of patients with profound zonular insufficiency. It is
the capsular bag and relatively few complications. designed for cases requiring optimal intraoperative sup-
port (Figs 4b, 4c) for significant zonular weakness, or for
patients in need of long-term postoperative centration of
an IOL within the capsular bag. This partial PMMA ring
Figure 4a CTS segment (Fig. 5) is 120˚ with a radius of 5 mm and, like
the M-CTR, the CTS also possesses an anteriorly posi-
tioned fixation eyelet.
Figure 4b CTS with iris retractor through eyelet for intra- Figure 4d Sutured CTS in place after surgery with well cen-
operative stabilization tered IOL
36 Cataract surgery and lens implantation
Figure 5 Dimensions of CTS can be challenging and may create further zonular
damage [23••]. As the CTS can be implanted without a
dialing technique and thus with much less force trans-
mitted to the zonular apparatus, it has a distinct advan-
tage over the CTR and M-CTR in these situations. The
CTS is designed to slide into the capsule bag with mini-
mal trauma, and thus may be used in cases of a discon-
tinuous capsulorhexis or anterior capsule tear, or a pos-
terior capsule rent. It is inserted into the capsule bag
after capsulorhexis and placed over the area of zonular
weakness. The main body of the device sits inside the
capsule bag supporting and extending the capsule equa-
tor. The central eyelet remains anterior to the capsule.
When used for intraoperative support, an inverted iris
retractor, via a paracentesis, is placed through the eyelet
acting as a coat hanger to support the capsule in the area
of zonular weakness (Figs 4b, 4c). For global weakness,
multiple CTS devices may be used in a similar fashion
[24••] (Fig. 6). Unlike other endocapsular devices, the
CTS may be used only as an intraoperative device and
can be easily removed once lens extraction is complete
or, as most surgeons do, it can be permanently suture-
fixated to the sclera, much like the M-CTR for long-
term capsular bag support and centration. It should be
distinguished that the CTS provides support in the
transverse plane when sutured to the scleral wall.
When circumferential support is also required, a CTR
may be implanted in conjunction with an already posi-
tioned CTS (authors’ preference).
The CTS is available in three different radii of curva- zonular weakness (nonprogressive compared with pro-
ture: 4.5 mm (model 6E), 5.0 mm (model 6D) and gressive) [24••]. It would perhaps be more useful to
5.5 mm (model 6C). also take into consideration the degree of zonular loss
and/or extent of generalized zonular instability.
In a consecutive series of 35 patients in which a CTS
was implanted with or without another support device, Nonprogressive zonulopathy such as traumatic or iatro-
IOL centration was achieved in all cases with no signif- genic zonular dialysis or zonular coloboma are well
icant IOL tilt [25]. Several combinations of devices were suited for standard CTRs as the remaining zonular fibers
used including the following: one CTS (nine patients), are usually quite strong and, with redistribution of these
two CTSs (eight patients), CTS + CTR (nine patients), forces with the CTR, can support the capsular bag
CTS + M-CTR (four patients), CTS + Iris coloboma [24••]. In progressive cases such as advanced pseudoex-
ring (one patient) and CTS + Iris diaphragm rings foliation syndrome or Marfan’s syndrome, however, a
(four patients). Two patients developed an intraopera- suturable M-CTR or CTS may be of optimal value as
tive anterior capsule tear and one patient develop a pos- it can be secured to the sclera. Further support can be
terior capsule rent, but the CTS was still successfully achieved as necessary by combining devices depending
implanted in these cases. Three patients developed on the amount of scleral-fixation needed. Moreover,
PCO. Initial outcomes have demonstrated the versatility endocapsular ring implantation does not eliminate the
of the CTS both as an intraoperative tool and implant underlying cause of zonular weakness and in severe
support device. cases of progressive dialysis it may be unavoidable
with a conventional CTR to prevent pseudophacodin-
Closed foldable capsular folding ring esis, further luxation or dislocation of the capsular bag
Dick [26] has recently introduced a new device, the complex into the vitreous [4••].
closed foldable capsular ring (CFCR), which is a fold-
able capsular tension and bending ring system with a CTRs are indicated in cases of mild, generalized zonular
sharp-edged design. The CFCR has eight hydrophobic weakness or small, localized zonular dialysis (less than
and eight hydrophilic ring segments. The minimum 3–4 clock hours). In cases of profound zonular insuffi-
overall diameter is 9.2 mm. This implant device can be ciency, a standard CTR may not supply enough intra-
inserted either manually with forceps and a two-folded operative and postoperative support to maintain the
technique or through an injector cartridge system. In desired orientation of the capsular bag.
their series of 104 eyes, this implant was inserted
through a small incision (1.6–3.2 mm) with no significant In more advanced or progressive cases of zonular
complications over 6-months follow-up. PCO was mini- instability, the Cionni M-CTR or the CTS(s) is indi-
mal or absent in all cases. cated. A 9.0 Prolene suture with double-armed CTC-6
needles (Ethicon Inc, Somerville, New Jersey) is passed
Current issues concerning capsular tension through the eyelet of the fixation hook of the CTS or
rings MCTR prior to implantation and fixated to sclera [27].
In this section we describe current issues concerning An ab-externo approach through a scleral groove to
CTR. suture the CTS or MCTR has been proposed, which
can be performed under topical anesthesia [28].
What device to use
A comparison of CTR, M-CTR and CTS is given in When to place the capsular tension ring
Table 3. Some surgeons feel that the choice of endocap- Issues concerning the timing of insertion are given in
sular support devices depends mainly on the nature of Table 4. The CTR can be inserted into the capsule
Table 4 Timing of CTR insertion Figure 7 Iris retractors placed at capsulorhexis edge to
stabilize loose capsular-zonular complex. They run the risk of
When to place a CTRa inadvertent dislodgement or anterior capsular tear
Prior to phaco
• Offers better nuclear stability for phacoemulsification
• More difficult with dense lens (higher risk of iatrogenic zonular
damage)
• Difficult to remove cortex
After phaco/cortical removal
• Use iris hooks during phaco/cortical irrigation and aspiration
• Risk of iris hook dislodgement (subsequent tears)
a
CTS may be inserted at any time due to atraumatic entry.
There are drawbacks to CTR implantation prior to Pseudoexfoliation and capsular tension devices
nuclear extraction. Entrapment of cortical material by Patients with pseudoexfoliation are excellent candidates
the CTR against the capsular bag may hinder removal for CTR implantation, due to associated progressive
[12]. Placing the CTS as an intraoperative device during zonular deterioration [2]. There is a debate, however,
phaco and cortex removal, however, helps solve this as to whether all pseudoexfoliation patients should
problem as it is much easier to strip cortex around the receive CTRs. These patients are at an increased risk
partial segment as opposed to the full ring structure. for intraoperative complications, as well as postoperative
IOL dislocation especially from superior zonular dialysis
CTR implantation prior to cataract removal may result [30,31]. Postoperative capsular phimosis is also an
in further iatrogenic zonular damage. Ahmed et al. [23••] impending risk in pseudoexfoliation syndrome.
using Miyake-Apple video analysis, have demonstrated Moreno-Montanes and Rodriguez-Conde [32] have
that early CTR implantation in cases with moderate recommended that CTR placement should be manda-
zonulysis results in significant zonular elongation and tory when operating on all patients with pseudoexfolia-
capsular displacement of up to 4 mm compared with tion. There is currently no evidence, however, demon-
later CTR implantation. Furthermore, if a capsular tear strating that pseudoexfoliation patients without any
ensues there is risk of CTR subluxation into the vitreous zonulopathy require an insertion of a CTR prophylacti-
body [12,14]. It is therefore recommended (authors’ pre- cally. Furthermore, even with CTR implantation, cer-
ference) that the optimal timing of CTR or M-CTR tain progressive cases may still dislocate years later
insertion into the capsular bag be as late as safely possi- [4••].
ble (CTS may be implanted early due to its atraumatic
insertion). For cases of serious zonular weakness, the Capsule phimosis
CTS may be used in conjunction with an iris retractor Due to weakened zonules exerting decreased centrifu-
for intraoperative support as described earlier. Alterna- gal forces, the contractile forces of an anterior fibrosing
tively, iris retractors or modified capsule retractors capsule may be overwhelming, thereby leading to cap-
(Mackool Cataract Support System, Duckworth and sular phimosis. Capsular contraction forces may be sym-
Kent Ltd, Hertfordshire, UK) placed on the capsulor- metric or asymmetric. Asymmetric forces cause the IOL
hexis (Fig. 7) may provide support, but risk capsular to shift to one side (usually the stronger side), whereas
tear or dislodgement, which is less likely with the symmetric contraction is less likely to result in lens
CTS. Performing phaco in profound zonular instability decentration.
Capsular tension rings and related devices Hasanee et al. 39
Tehrani et al. [33] showed a positive correlation between Kurz and Dick [42] demonstrated that the spring con-
capsular bag shrinkage and axial length in their study stant of a CTR is a suitable mechanical characteristic
with the capsule measuring ring (HumanOptics, Erlan- to facilitate the choice of CTR model. They found
gen, Germany). Utilizing preoperative biometric data, a that CTRs with lower spring constants were more
regression formula of moderate validity was determined advantageous for the management of zonular dialysis,
to predict the amount of capsular bag shrinkage. whereas higher spring constant CTRs were ideal for
the prevention of capsular bag shrinkage.
Although it was initially felt that anterior capsule con-
traction following cataract surgery with CTR placement How to manage capsular tension ring dislocation
might be prevented [3,34], more recent reports have Postoperative CTR subluxation or dislocation is a risk
indicated that capsular phimosis is still a postoperative for patients with severe or progressive zonulysis. In a
concern despite CTR implantation [29]. Capsular con- retrospective interventional case-series of 11 patients,
traction to the point of complete capsulorhexis opening Ahmed et al. [4••] demonstrated that CTR decentra-
occlusion has also been reported despite CTR use [34, tions, including into posterior vitreous, may be effec-
35]. Capsular contraction has occurred following CTR tively managed with scleral-suture fixation of the CTR
implantation with IOLs made from silicone, PMMA through the fibrotic capsular bag, or with the placement
and acrylic materials [34]. CTRs are still beneficial in of a CTS under the anterior capsule to reposition the
these situations, however, as the capsular contraction is displaced apparatus.
typically symmetrical as opposed to asymmetrical with-
out the use of a CTR, thus reducing the risk of IOL In cases where a CTR displaced into the vitreous cavity
cannot be repositioned, several techniques of retrieval
decentration.
have been reported. Lang et al. [14] have reported the
successful removal of an intact ring through a sclerotomy
Methods to further reduce the risk of capsule contrac-
site. Another possible approach is to cut the fallen ring
tion syndrome include creating a capsulorhexis opening
into two halves and remove each half by using two
of 5.5–6.0 mm, use of an acrylic IOL [36–39], aspiration
forceps utilizing a bimanual technique [43]. A third
of lens epithelial cells (LECs) on the undersurface of
technique proposed by Ma et al. [44] appears to be the
the anterior capsule to reduce LEC proliferation and
most viable and safest option. This approach encom-
metaplasia [40]. LEC metaplasia and fibrosis may also
passes the use of a CTR injector to withdraw the ring
be reduced by the presence of an endocapsular ring by
in one piece through the initial phaco incision.
decreasing contact between the optic and anterior cap-
sule [41]. Anterior capsule relaxing incisions either dur- Posterior capsule opacification
ing surgery with microscissors or after surgery with a Nd: Although the incidence of PCO is reduced with the use
YAG anterior capsulotomy is a critical step to prevent of CTRs [8], PCO has still been reported after surgery
decentration (Fig. 8). [24••]. To minimize the risk of PCO, Nishi et al.’s [41]
capsular bending ring (CBR) may be utilized, with the
added feature of a square edge. This model has been
Figure 8 CTS with Nd:YAG radial cuts to anterior capsule for
capsule contracture. IOL is well centered shown to significantly reduce the risk of posterior cap-
sule epithelial growth [41]. In additional, Dick et al. [45]
reported that combining a viscoadaptive viscoelastic
agent and a CBR not only enhances the safety of pri-
mary and secondary PCIOL implantation and IOL
exchange in pediatric cases, but also reduces PCO. A
square-edged IOL design used in conjunction with a
CTR may also decrease the incidence of PCO [38].
Conclusion
Endocapsular devices offer numerous advantages in
situations of zonular insufficiency including reestablish-
40 Cataract surgery and lens implantation
ment of the capsular bag contour, decreased risk of 15 Hara T, Hara T, Yamada Y. ‘Equator ring’ for maintenance of the completely
PCO, decreased capsular bag collapse and risk of aspira- circular contour of the capsular bag equator after cataract removal. Ophthal-
mic Surg 1991; 22:358–359.
tion, limited late IOL decentration due to asymmetric
16 Nagamoto T, Bissen-Miyajima H. A ring to support the capsular bag after
capsule contraction, decreased irrigation fluid passing continuous curvilinear capsulorhexis. J Cataract Refract Surg 1994; 20:
behind the capsule, decreased risk of vitreous hernia- 417–420.
tion, decreased IOL decentration, closure of the capsule 17 Lee DH, Shin SC, Joo CK. Effect of a capsular tension ring on intraocular
lens decentration and tilting after cataract surgery. J Cataract Refract Surg
and extension of zonular dialysis [46]. 2002; 28:843–846.
18 Vass C, Menapace R, Schetterer K, et al. Prediction of pseudophakic capsu-
Over the past decade, there have been dramatic lar bag diameter based on biometric variables. J Cataract Refract Surg
advances in the management of zonular weakness. 1999; 25:1376–1381.
From the advent of the capsular tension ring to the 19 Lam DS, Young AL, Leung AT, et al. Scleral fixation of a capsular tension ring
for severe ectopia lentis. J Cataract Refract Surg 2000; 26:609–612.
more recent CTS, each device has served to play a spe-
20 Cionni RJ, Osher RH, Marques DM, et al. Modified capsular tension ring for
cific role in the management of weak zonules in cataract patients with congenital loss of zonular support. J Cataract Refract Surg
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21 Ahmed IIK, Crandall AS, Kranemann C, Goldsmith J. Clinical Results of the
References and recommended reading
.
! Cionni Modified Capsular Tension Ring for Sever Zonular Weakness. Amer-
Papers of particular interest, published within the annual period of review, have ican Academy of Ophthalmology Meeting, New Orleans, Louisiana; October
been highlighted as: 2004. Paper Session.
• of special interest This paper demonstrates that the M-CTR can be used in a variety of clinical
•• of outstanding interest situations.
Additional references related to this topic can also be found in the Current
22 Moreno-Montanes J, Sainz C, Maldonado MJ. Intraoperative and postopera-
World Literature section in this issue (p. 105).
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