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Pharmaceutical Chemistry Lab. Report

Compound I (MWt: 92.52 g/mol, 1.52 g) and compound II (MWt: 192.22 g/mol, 2.883 g) were refluxed in isopropyl alcohol for 20 hours. Sodium bicarbonate and water were then added and refluxed for an additional 1.5 hours. The reaction mixture was purified via column chromatography to yield compound III (1.675 g) with a percent yield of 44.97%.

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Mohammed Haider
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76 views2 pages

Pharmaceutical Chemistry Lab. Report

Compound I (MWt: 92.52 g/mol, 1.52 g) and compound II (MWt: 192.22 g/mol, 2.883 g) were refluxed in isopropyl alcohol for 20 hours. Sodium bicarbonate and water were then added and refluxed for an additional 1.5 hours. The reaction mixture was purified via column chromatography to yield compound III (1.675 g) with a percent yield of 44.97%.

Uploaded by

Mohammed Haider
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© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Pharmaceutical chemistry Lab.

Report
O
O O
Cl + IPA H
O N NH2 O N N
I Reflux, 20 h
O II III

MWt: 92.52 MWt: 192.22 MWt: 248.28


Wt= 1.52 g Wt= 2.883 g

1. The name of the experiment: experiment 7


2. Number of the experiment: 7
3. Name of the student performing the experiment: ‫محمد حيدر كمال محمود‬
4- Material used in the experiment

Name MWt. Wt. mmol Note


isopropyl 75 mL used a s
alcohol a solvent
NaHCO3 84 1.513 g 18
Water 100 ml
Na2SO4 Used for drying
compound (I) 92.52 1.52 16.4
compound (II) 192.22 2.883 15

5- Procedure:
A suspension of compound (II) (2.883 g, 1 mmol) was made in isopropyl alcohol (IPA)
(75 mL) then (1.52 g, 1 mmol) of compound (I) was added to the suspension. Then the
mixture was Refluxed for 20 h. After that a solution of NaHCO3 (1.513 g) was added to
water (30 mL) and was refluxed for another 1.5 h. The reaction was then stopped. Using
rotatory evaporator, the solution was evaporated. The residue was diluted with water (100
mL) and extracted with EtOAc (3x50 mL). After that the organic layer was collected and
dried over Na2SO4. The solvent was then evaporated. The residue was purified by column
chromatography using silica (500 g) as a stationary phase and 80% EtOAc-heptane as
mobile phase. TLC was used to collect fractions that was expected to contain the product.
These fractions were combined together. The solvent was removed using evaporation and
yellow powder was obtained, the powder was dried in vacuo to obtain compound (III)
(1.675 g).
6- Calculation
Compound I
Mole = w/Mw = 1.52/92.52 = 0.0164 mole
Compound II
Mole = w/Mw = 2.883/192.22 = 0.015 mole
Since compound II will be consumed completely at the end of the reaction, it is the
limiting agent and there will be an excess of compound I.

The theoretical yield


W= mole * molecular weight = 0.015 * 248.28 = 3.7242 g

Actual yield was 1.675 g

Percent yield = practical weight*100%/ theoretical yield = 1.675*100%/ 3.7242


Percent yield = 44.9761023%

7- Discussion

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