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    Amoxicillin Clavulanate Potassium

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    Janelle Narciso
    This document provides information on the generic and brand names, classification, mode of action, dosing, indications, contraindications, side effects, adverse effects, drug interactions, and nursing responsibilities for the antibiotic Amoxicillin/Clavulanate Potassium, which is commonly known by the brand name Augmentin. It is a penicillin and beta-lactamase inhibitor combination antibiotic that is bactericidal and effective against both gram-positive and gram-negative bacteria. Common indications include respiratory, skin, and urinary tract infections. Side effects include diarrhea, rash, nausea and vomiting. Nurses should monitor for signs of superinfection or allergic reaction.

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    Amoxicillin Clavulanate Potassium

    Uploaded by

    Janelle Narciso
    135 views4 pages
    This document provides information on the generic and brand names, classification, mode of action, dosing, indications, contraindications, side effects, adverse effects, drug interactions, and nursing responsibilities for the antibiotic Amoxicillin/Clavulanate Potassium, which is commonly known by the brand name Augmentin. It is a penicillin and beta-lactamase inhibitor combination antibiotic that is bactericidal and effective against both gram-positive and gram-negative bacteria. Common indications include respiratory, skin, and urinary tract infections. Side effects include diarrhea, rash, nausea and vomiting. Nurses should monitor for signs of superinfection or allergic reaction.

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    AMOXICILLIN CLAVULANATE POTASSIUM

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    This document provides information on the generic and brand names, classification, mode of action, dosing, indications, contraindications, side effects, adverse effects, drug interactions, and nursing responsibilities for the antibiotic Amoxicillin/Clavulanate Potassium, which is commonly known by the brand name Augmentin. It is a penicillin and beta-lactamase inhibitor combination antibiotic that is bactericidal and effective against both gram-positive and gram-negative bacteria. Common indications include respiratory, skin, and urinary tract infections. Side effects include diarrhea, rash, nausea and vomiting. Nurses should monitor for signs of superinfection or allergic reaction.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    135 views4 pages

    Amoxicillin Clavulanate Potassium

    Uploaded by

    Janelle Narciso
    This document provides information on the generic and brand names, classification, mode of action, dosing, indications, contraindications, side effects, adverse effects, drug interactions, and nursing responsibilities for the antibiotic Amoxicillin/Clavulanate Potassium, which is commonly known by the brand name Augmentin. It is a penicillin and beta-lactamase inhibitor combination antibiotic that is bactericidal and effective against both gram-positive and gram-negative bacteria. Common indications include respiratory, skin, and urinary tract infections. Side effects include diarrhea, rash, nausea and vomiting. Nurses should monitor for signs of superinfection or allergic reaction.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    GENERIC NAME: Amoxicillin / Clavulanate Potassium

    BRAND NAME: Augmentin

    ACTION CLASSIFICATION:

    Penicillin and Beta – Lactamase Inhibitor Combination

    Antibiotics

    MODE OF ACTION:

    Amoxicillin binds to penicillin- binding proteins, thus inhibiting final

    transpeptidation step of peptidoglycan synthesis in bacterial cell walls; addition of

    clavulanate inhibits beta-lactamase- producing bacteria, allowing amoxicillin extended

    spectrum of action. It is a semisynthetic antibiotic with a broad spectrum of bactericidal

    activity, covering both gram-negative and gram-positive microorganisms. Not effective

    against Mycoplasma and Legionella spp. Therapeutic Effect: Amoxicillin is bactericidal

    in susceptible microorganisms. Clavulanate protects amoxicillin from enzymatic

    degradation.

    DOSE AND ROUTE:

    PO: Children older than 3 months, weighing 40 kg or more: (Mild – Moderate): 500

    mg q12h or 250 mg q8h. (Severe): 875 mg q12h or 500 mg q8h. (Extended-Release):

    2,000 mg q12h. Weighing less than 40 kg: (Mild-Moderate): 25 mg /kg/day in 2

    divided doses or 20 mg/kg/day in 3 divided doses. (Severe): 45 mg/kg/day in 2 divided

    doses or 40 mg/kg/day in 3 divided doses. Maximum Single Dose: 500 mg. Less than 3

    months: Amoxicillin 30 mg/kg/day divided q12h using 125mg/5 ml suspension only.


    INDICATIONS:

     Lower respiratory tract infection

     Chronic obstructive pulmonary disease

     Acute bacterial sinusitis

     UTI

     Erysipelas

     Pyelonephritis

     Skin Abscess

     Diabetic Foot

     Group A Streptococci, Chronic Carrier

    CONTRAINDICATIONS:

     Hypersensitivity to amoxicillin, clavulanate, any penicillins.

     History of cholestatic jaundice or hepatic impairment with amoxicillin/ clavulanate

    therapy

    SIDE EFFECTS:

     Diarrhea

     Rash

     Nausea

     Vomiting
    ADVERSE EFFECTS:

    Antibiotic-associated colitis, other superinfections (abdominal cramps, severe

    watery diarrhea; fever) may result from altered bacterial balance in GI tract. Severe

    hypersensitivity reactions, including anaphylaxis, acute interstitial nephritis, occur rarely.

    DRUG INTERACTIONS:

     Allopurinol may increase incidence of rash.

     Probenecid may increase concentration, toxicity risk.

    NURSING RESPONSIBILITIES:

    1. Assess client for any history of allergies, especially penicillins, cephalosporins,

    renal impairment

    R: For baseline data and to avoid occurrence of allergic reactions

    2. Instruct client to report if any of the following occurs:

     Rash

     Diarrhea (fever, abdominal pain, mucus and blood in stool)

    R: this may indicate antibiotic-associated colitis

    3. Monitor client for fever, vomiting, diarrhea. Black “hairy” tongue, ulceration or

    changes of oral mucosa, anal or genital pruritus

    R: these are signs of superinfections.

    4. Monitor Renal and Hepatic tests with prolonged therapy


    R: to assess for the effectiveness of the drug

    5. Instruct client to increase oral fluid intake

    R: to maintain adequate hydration

    REFERENCES:

    Augmentin, Augmentin XR (amoxicillin/clavulanate) dosing, indications, interactions,

    adverse effects and more. (2019, September 28). Retrieved from

    https://reference.medscape.com/drug/augmentin-amoxicillin-clavulanate-

    342474#10

    Kizior, R. J., & Hodgson, K. J. (2020). Saunders nusing drug handbook 2020. St. Louis,

    MO:Elsevier.

    MIMS Australia. (2019). Mims annual: June 2019. St Leonards, N.S.W.

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